Title:
METHODS AND COMPOSITIONS FOR SYNERGISTIC UPTAKE AND RETENTION OF SMALL MOLECULE LIGANDS
Document Type and Number:
WIPO Patent Application WO/2022/072293
Kind Code:
A3
Abstract:
The present application relates to methods of treating a subject for cancer. The method involves providing a first agent comprising a first targeting component coupled to a first cancer therapeutic component and providing a second agent comprising a second targeting component coupled to a second cancer therapeutic component. The first and second targeting components have different biodistributions and/or pharmacokinetics in the subject. The first and second agents are administered no more than eight hours apart from each other, to the subject to treat cancer. As a result of the administering, the amount of first and second cancer therapeutic component internalized and retained within a tumor is greater than the sum of first and second cancer therapeutic component internalized and retained in a tumor if each of the first and second agents were administered alone. Also disclosed is a combination therapeutic comprising the first and second agents blended together.
Inventors:
BANDER NEIL (US)
Application Number:
PCT/US2021/052271
Publication Date:
July 21, 2022
Filing Date:
September 28, 2021
Export Citation:
Assignee:
UNIV CORNELL (US)
International Classes:
A61K39/395; A61K47/64; A61K47/66; A61K47/68; A61K51/08; A61K51/10; C07K16/18; C07K16/28
Domestic Patent References:
| WO2018204477A1 | 2018-11-08 | |||
| WO2022072293A2 | 2022-04-07 |
Foreign References:
| US9574006B2 | 2017-02-21 |
Attorney, Agent or Firm:
GOLDMAN, Michael, L. et al. (US)
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