METHODS AND COMPOSITIONS FOR T CELL DIFFERENTIATION

Title:

METHODS AND COMPOSITIONS FOR T CELL DIFFERENTIATION

Document Type and Number:

WIPO Patent Application WO/2024/076499

Kind Code:

A3

Abstract:

The technology described herein is directed to stromal-free methods of T cell differentiation using a soluble Notch ligand. Also described herein are soluble Notch oligomer complexes and compositions thereof, and methods for making the same. Further described herein are immune cells differentiated using stromal -free methods and compositions comprising such immune cells. In some embodiments, the immune cells can be genetically modified. In some embodiments, the immune cells or compositions comprising said immune cells can be administered to a patient as a cellular replacement therapy to treat a condition.

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Inventors:

DALEY GEORGE Q (US)
MOUT RUBUL (US)
JING RAN (US)
BAKER DAVID (US)
BLACKLOW STEPHEN (US)
EGAN EMILY D (US)

Application Number:

PCT/US2023/034086

Publication Date:

May 16, 2024

Filing Date:

September 29, 2023

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Assignee:

CHILDRENS MEDICAL CT CORP (US)
UNIV WASHINGTON (US)
HARVARD COLLEGE (US)

International Classes:

A61K35/17; A61K38/17; A61P35/02; A61P37/04; C07K14/435; C12N9/10; C12N5/0735; C12N5/0783

Attorney, Agent or Firm:

JODOIN, Jeanne Nicole et al. (US)

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