Title:
METHODS AND COMPOSITIONS FOR TARGETING PROTEINS ACROSS THE BLOOD BRAIN BARRIER
Document Type and Number:
WIPO Patent Application WO2003032913
Kind Code:
A3
Abstract:
Disclosed are methods and compositions for targeting therapeutic proteins to the brain. Methods and compositions of the invention involve associating an IGF moiety with a therapeutic protein in order to target the therapeutic protein to the brain. Soluble fusion proteins that include an IGF targeting moiety are transported to neural tissue in the brain from blood. Methods and compositions of the invention include therapeutic applications for treating lysosomal storage diseases. The invention also provides nucleic acids and cells for expressing IGF fusion proteins.
Inventors:
LEBOWITZ JONATHAN H (US)
Application Number:
PCT/US2002/032996
Publication Date:
August 12, 2004
Filing Date:
October 16, 2002
Export Citation:
Assignee:
SYMBIONTICS INC (US)
LEBOWITZ JONATHAN H (US)
LEBOWITZ JONATHAN H (US)
International Classes:
A61K38/27; A61K38/30; A61K38/46; A61K47/42; A61K47/48; A61K48/00; A61P9/10; C12N15/09; A61P13/12; C07K14/47; C07K14/65; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/02; C12N5/10; C12N15/18; C12N15/62; A61K38/00; (IPC1-7): A61K38/04; A61K38/30; A61K38/43; A61K48/00; C07K14/65; C12N1/21; C12N5/10; C12N15/18
Foreign References:
| US4801575A | 1989-01-31 |
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