Title:
METHODS AND COMPOSITIONS TARGETING TYROSINE KINASES FOR THE DIAGNOSIS AND TREATMENT OF OSTEOARTHRITIS
Document Type and Number:
WIPO Patent Application WO2004092735
Kind Code:
A3
Abstract:
The invention discloses that members of a subfamily of receptor tyrosine kinases comprising TYRO3, Axl, cMer and ligands thereof, such as GAS6 are suitable targets for the development of new therapeutics to treat, prevent or ameliorate OA. The invention also relates to methods to treat and/or ameliorate OA and pharmaceutical compositions therefor comprising modulators with inhibitory effect on the expression or activity of members of this subfamily of receptor tyrosine and related ligands. The invention also relates to a method to identify compounds with therapeutic usefulness to treat OA, comprising identifying compounds that can, e.g., inhibit activity and/or expression of these polypeptides.
Inventors:
DAOUTI SHERIF (US)
KUMAR CHANDRIKA SAIDAPET (US)
LATARIO BRIAN JUDE (US)
KUMAR CHANDRIKA SAIDAPET (US)
LATARIO BRIAN JUDE (US)
Application Number:
PCT/EP2004/004052
Publication Date:
March 17, 2005
Filing Date:
April 16, 2004
Export Citation:
Assignee:
NOVARTIS AG (CH)
NOVARTIS PHARMA GMBH (AT)
DAOUTI SHERIF (US)
KUMAR CHANDRIKA SAIDAPET (US)
LATARIO BRIAN JUDE (US)
NOVARTIS PHARMA GMBH (AT)
DAOUTI SHERIF (US)
KUMAR CHANDRIKA SAIDAPET (US)
LATARIO BRIAN JUDE (US)
International Classes:
G01N33/68; (IPC1-7): G01N33/573; G01N33/566; C12Q1/48
Domestic Patent References:
| WO2002081745A2 | 2002-10-17 | |||
| WO2004029209A2 | 2004-04-08 |
Foreign References:
| US6096527A | 2000-08-01 | |||
| US5709858A | 1998-01-20 | |||
| EP0524737A2 | 1993-01-27 | |||
| US5663142A | 1997-09-02 |
Other References:
O'DONNELL K. ET AL.: "Expression of receptor tyrosine kinase Axl and its ligand Gas6 in rheumatoid arthritis.", AM. J. PATHOL., vol. 154, no. 4, April 1999 (1999-04-01), pages 1171 - 1180, XP000971169
NAKAMURA Y.S. ET AL.: "Tyro 3 receptor tyrosine kinase and its ligand, Gas6, stimulate the function of osteoclasts.", STEM CELLS, vol. 16, 1998, pages 229 - 238, XP002312139
KATAGIRI M. ET AL.: "Mechanism of stimulation of osteoclastic bone resorption through Gas6/Tyro 3, a receptor tyrosine kinase signaling, in mouse osteoclasts.", J. BIOL. CHEM., vol. 276, no. 10, 9 March 2001 (2001-03-09), pages 7376 - 7382, XP002312140
NAKAMURA Y.S. ET AL.: "Tyro 3 receptor tyrosine kinase and its ligand, Gas6, stimulate the function of osteoclasts.", STEM CELLS, vol. 16, 1998, pages 229 - 238, XP002312139
KATAGIRI M. ET AL.: "Mechanism of stimulation of osteoclastic bone resorption through Gas6/Tyro 3, a receptor tyrosine kinase signaling, in mouse osteoclasts.", J. BIOL. CHEM., vol. 276, no. 10, 9 March 2001 (2001-03-09), pages 7376 - 7382, XP002312140
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