Title:
METHODS AND COMPOSITIONS TO ALLEVIATE VASCULAR PERMEABILITY
Document Type and Number:
WIPO Patent Application WO/2019/232203
Kind Code:
A3
Abstract:
In various aspects and embodiments the invention provides compositions and methods useful in the treatment of diseases related to vascular permeability. In another aspect, the invention provides a method of treating a vascular permeability related disease in a subject, the method comprising administering to the subject an effective amount of a syndecan-2 disrupting agent.
Inventors:
SIMONS MICHAEL (US)
CORTI FEDERICO (US)
CORTI FEDERICO (US)
Application Number:
PCT/US2019/034644
Publication Date:
July 30, 2020
Filing Date:
May 30, 2019
Export Citation:
Assignee:
UNIV YALE (US)
International Classes:
C07K7/08; C07K14/78
Domestic Patent References:
| WO2017087825A1 | 2017-05-26 |
Foreign References:
| US20170320929A1 | 2017-11-09 | |||
| US20160271211A1 | 2016-09-22 |
Other References:
FOURNIER ET AL.: "Tyrosine Phosphatase PTPRJ/DEP-1 Is an Essential Promoter of Vascular Permeability, Angiogenesis, and Tumor Progression", CANCER RES, vol. 76, no. 17, 1 September 2016 (2016-09-01), pages 5080 - 5091, XP055726899
Attorney, Agent or Firm:
DOYLE, Kathryn et al. (US)
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