Title:
METHODS AND COMPOSITIONS TO PREVENT FORMATION OF ADHESIONS IN BIOLOGICAL TISSUES
Document Type and Number:
WIPO Patent Application WO1999010022
Kind Code:
A3
Abstract:
The invention discloses materials that adsorb readily to the surfaces of body tissues in situ and provide a steric barrier between such tissues, so that tissue adhesions, which typically form following surgical procedures, are minimized. These materials contain a polymer of hydrophilic molecules such as polyethylene glycol (PEG) bound to a polymer that spontaneously adsorbs to biological tissue such as phenylboronic acid (PBA). The PEG-PBA co-polymer can be formed in a variety of geometries. The materials can also be used to coat prosthetics and other implants.
Inventors:
HUBBELL JEFFREY A
WINBLADE NATALIE D
ELBERT DONALD L
WINBLADE NATALIE D
ELBERT DONALD L
Application Number:
PCT/US1998/017754
Publication Date:
June 10, 1999
Filing Date:
August 27, 1998
Export Citation:
Assignee:
CALIFORNIA INST OF TECHN (US)
International Classes:
A61K31/77; A61K31/78; A61L31/00; A61K31/79; A61K31/80; A61L27/34; A61L29/00; A61L31/06; A61L31/10; C08L101/02; (IPC1-7): A61L31/00; C08L101/02
Other References:
AOKI T. ET AL.: "Endothelial cell differentiation into capillary structures by copolymer surfaces with phenylboronic acid groups", JOURNAL OF BIOMATERIALS SCIENCE, POLYMER EDITION, vol. 7, no. 7, 1995, pages 539 - 550, XP002097651
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