Title:
METHODS AND COMPOSITIONS TO SLOW DOWN AGING IN CELLS AND ORGANISMS
Document Type and Number:
WIPO Patent Application WO/2017/102738
Kind Code:
A1
Abstract:
A method to slow down and mitigate aging and to maintain health by administering a composition comprising at least one protein-homeostasis-influencing saccharide-based substance, an anti-amyloidogenic substance, a Krebs cycle metabolite, glycine, gingko biloba, low dose lithium, a prebiotic, or combinations thereof, enabling a synergistic and enhancing effect on the aging process and well-being due to their interaction and synergetic influence on protein homeostasis and various other aging-related mechanisms.
Inventors:
VERBURGH KRIS (BE)
Application Number:
PCT/EP2016/080815
Publication Date:
June 22, 2017
Filing Date:
December 13, 2016
Export Citation:
Assignee:
VERBURGH KRIS (BE)
International Classes:
A23L33/105; A23L2/385; A23L33/125; A23L33/16; A23L33/17; A61K8/60; A61K47/26
Domestic Patent References:
| WO2001039615A1 | 2001-06-07 |
Foreign References:
| US20090110671A1 | 2009-04-30 | |||
| CA2722314A1 | 2009-11-05 | |||
| US20040038929A1 | 2004-02-26 | |||
| CA2737797A1 | 2012-10-29 | |||
| US20090162487A1 | 2009-06-25 |
Other References:
ANONYMOUS: "Fruit Flavoured Collagen Drinks - Record ID 1527381", GNPD, 1 April 2011 (2011-04-01), pages 1 - 5, XP055352346, Retrieved from the Internet [retrieved on 20170307]
WILL BLOCK: "Trehalose and Other Osmolyte Supplements Help Stabilize Proteins for Longevity", LIFE ENHANCEMENT, 1 February 2014 (2014-02-01), pages 1 - 6, XP055352822, Retrieved from the Internet [retrieved on 20170308]
DONGYEOP LEE ET AL: "Effects of nutritional components on aging", AGING CELL, vol. 14, no. 1, 22 October 2014 (2014-10-22), GB, pages 8 - 16, XP055352804, ISSN: 1474-9718, DOI: 10.1111/acel.12277
DATABASE WPI Week 201157, Derwent World Patents Index; AN 2011-K74348, XP002767962, "Chinese yam drink useful for preventing aging, comprises trehalose, sucrose fatty acid ester and tripolyglycerol monostearate"
VINCE GUILIANO ET AL: "Trehalose - a natural sugar that could possibly be consumed for health and longevity | AGINGSCIENCES(TM) - Anti-Aging Firewalls(TM)", HTTP://WWW.ANTI-AGINGFIREWALLS.COM/2014/06/18/TREHELOSE-A-NATURAL-SUGAR-THAT-COULD-POSSIBLY-BE-CONSUMED-FOR-HEALTH-AND-LONGEVITY/, 18 June 2014 (2014-06-18), pages 1 - 14, XP055352409, Retrieved from the Internet
KIM ZARSE ET AL: "Low-dose lithium uptake promotes longevity in humans and metazoans", EUROPEAN JOURNAL OF NUTRITION, STEINKOPFF-VERLAG, DA, vol. 50, no. 5, 8 February 2011 (2011-02-08), pages 387 - 389, XP019935765, ISSN: 1436-6215, DOI: 10.1007/S00394-011-0171-X
P. D. MANGAN: "Glycine supplementation could reverse aging", ROGUE HEALTH AND FITNESS, 8 June 2015 (2015-06-08), pages 1 - 9, XP055352872, Retrieved from the Internet
GEORGE L SUTPHIN ET AL: "Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans", LONGEVITY & HEALTHSPAN, BIOMED CENTRAL LTD, LONDON, UK, vol. 1, no. 1, 1 December 2012 (2012-12-01), pages 9, XP021130195, ISSN: 2046-2395, DOI: 10.1186/2046-2395-1-9
BJELAKOVIC, G.; NIKOLOVA, D.; GLUUD, L. L.; SIMONETTI, R. G.; GLUUD, C.: "Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis", JAMA, vol. 297, 2007, pages 842 - 57
MACPHERSON, H; PIPINGAS, A.; PASE, M. P.: "Multivitamin-multimineral supplementation and mortality: a meta-analysis of randomized controlled trials.", AM. J. CLIN. NUTR, vol. 97, 2013, pages 437 - 44
SESSO, H. D. ET AL.: "Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial", JAMA, vol. 308, 2012, pages 1751 - 60
SAYIN, V. I. ET AL.: "Antioxidants accelerate lung cancer progression in mice.", SCI. TRANSL. MED., vol. 6, 2014
RISTOW, M. ET AL.: "Antioxidants prevent health-promoting effects of physical exercise in humans.", PROC. NATL. ACAD. SCI. U. S. A., vol. 106, 2009, pages 8665 - 70
YANG, W.; HEKIMI, S.: "A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.", PLOS BIOL., vol. 8, 2010
WILL BLOCK: "Trehalose and Other Osmolyte Supplements Help Stabilize Proteins for Longevity", LIFE ENHANCEMENT, 1 February 2014 (2014-02-01), pages 1 - 6, XP055352822, Retrieved from the Internet
DONGYEOP LEE ET AL: "Effects of nutritional components on aging", AGING CELL, vol. 14, no. 1, 22 October 2014 (2014-10-22), GB, pages 8 - 16, XP055352804, ISSN: 1474-9718, DOI: 10.1111/acel.12277
DATABASE WPI Week 201157, Derwent World Patents Index; AN 2011-K74348, XP002767962, "Chinese yam drink useful for preventing aging, comprises trehalose, sucrose fatty acid ester and tripolyglycerol monostearate"
VINCE GUILIANO ET AL: "Trehalose - a natural sugar that could possibly be consumed for health and longevity | AGINGSCIENCES(TM) - Anti-Aging Firewalls(TM)", HTTP://WWW.ANTI-AGINGFIREWALLS.COM/2014/06/18/TREHELOSE-A-NATURAL-SUGAR-THAT-COULD-POSSIBLY-BE-CONSUMED-FOR-HEALTH-AND-LONGEVITY/, 18 June 2014 (2014-06-18), pages 1 - 14, XP055352409, Retrieved from the Internet
KIM ZARSE ET AL: "Low-dose lithium uptake promotes longevity in humans and metazoans", EUROPEAN JOURNAL OF NUTRITION, STEINKOPFF-VERLAG, DA, vol. 50, no. 5, 8 February 2011 (2011-02-08), pages 387 - 389, XP019935765, ISSN: 1436-6215, DOI: 10.1007/S00394-011-0171-X
P. D. MANGAN: "Glycine supplementation could reverse aging", ROGUE HEALTH AND FITNESS, 8 June 2015 (2015-06-08), pages 1 - 9, XP055352872, Retrieved from the Internet
GEORGE L SUTPHIN ET AL: "Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans", LONGEVITY & HEALTHSPAN, BIOMED CENTRAL LTD, LONDON, UK, vol. 1, no. 1, 1 December 2012 (2012-12-01), pages 9, XP021130195, ISSN: 2046-2395, DOI: 10.1186/2046-2395-1-9
BJELAKOVIC, G.; NIKOLOVA, D.; GLUUD, L. L.; SIMONETTI, R. G.; GLUUD, C.: "Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis", JAMA, vol. 297, 2007, pages 842 - 57
MACPHERSON, H; PIPINGAS, A.; PASE, M. P.: "Multivitamin-multimineral supplementation and mortality: a meta-analysis of randomized controlled trials.", AM. J. CLIN. NUTR, vol. 97, 2013, pages 437 - 44
SESSO, H. D. ET AL.: "Multivitamins in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial", JAMA, vol. 308, 2012, pages 1751 - 60
SAYIN, V. I. ET AL.: "Antioxidants accelerate lung cancer progression in mice.", SCI. TRANSL. MED., vol. 6, 2014
RISTOW, M. ET AL.: "Antioxidants prevent health-promoting effects of physical exercise in humans.", PROC. NATL. ACAD. SCI. U. S. A., vol. 106, 2009, pages 8665 - 70
YANG, W.; HEKIMI, S.: "A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.", PLOS BIOL., vol. 8, 2010
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