Title:
METHODS AND COMPOSITIONS FOR TREATING CANCER WITH IMMUNE CELLS
Document Type and Number:
WIPO Patent Application WO/2022/074464
Kind Code:
A3
Abstract:
The invention provides methods or compositions for treating cancer using an immune cell, e.g, a T-cell, e.g., a CAR T-cell, optionally in combination with a superantigen conjugate. The invention also provides methods for making immune cells, e.g, T-cells, e.g, CAR T-cells, for use in the treatment of cancer.
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Inventors:
SHAHAR MICHAL (IL)
NATHAN ASHER (IL)
SAGI YAEL (IL)
NATHAN ASHER (IL)
SAGI YAEL (IL)
Application Number:
PCT/IB2021/000934
Publication Date:
September 29, 2022
Filing Date:
March 05, 2021
Export Citation:
Assignee:
NEOTX THERAPEUTICS LTD (IL)
International Classes:
A61K39/00
Domestic Patent References:
| WO2019109047A1 | 2019-06-06 | |||
| WO2018167486A1 | 2018-09-20 | |||
| WO2017122098A2 | 2017-07-20 |
Other References:
G. HEDLUND ET AL: "The Tumor Targeted Superantigen ABR-217620 Selectively Engages TRBV7-9 and Exploits TCR-pMHC Affinity Mimicry in Mediating T Cell Cytotoxicity", PLOS ONE, vol. 8, no. 10, 23 October 2013 (2013-10-23), pages 1 - 17, XP055136323, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0079082
VON SCHEIDT BIANCA ET AL: "Enterotoxins can support CAR T cells against solid tumors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 116, no. 50, 25 November 2019 (2019-11-25), pages 25229 - 25235, XP055847245, ISSN: 0027-8424, Retrieved from the Internet DOI: 10.1073/pnas.1904618116
STERN PETER L ET AL: "5T4 oncofoetal antigen: an attractive target for immune intervention in cancer", CANCER IMMUNOLOGY IMMUNOTHERAPY, SPRINGER, BERLIN/HEIDELBERG, vol. 66, no. 4, 18 October 2016 (2016-10-18), pages 415 - 426, XP037138983, ISSN: 0340-7004, [retrieved on 20161018], DOI: 10.1007/S00262-016-1917-3
VON SCHEIDT BIANCA ET AL: "Enterotoxins can support CAR T cells against solid tumors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 116, no. 50, 25 November 2019 (2019-11-25), pages 25229 - 25235, XP055847245, ISSN: 0027-8424, Retrieved from the Internet
STERN PETER L ET AL: "5T4 oncofoetal antigen: an attractive target for immune intervention in cancer", CANCER IMMUNOLOGY IMMUNOTHERAPY, SPRINGER, BERLIN/HEIDELBERG, vol. 66, no. 4, 18 October 2016 (2016-10-18), pages 415 - 426, XP037138983, ISSN: 0340-7004, [retrieved on 20161018], DOI: 10.1007/S00262-016-1917-3
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