Attorney Docket No.: NVM-004WO METHODS AND COMPOSITIONS FOR TREATING HYPEROXALURIA CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of, and priority to, U.S. provisional patent application serial number 62/777,322, filed December 10, 2018, which is hereby incorporated by reference herein in its entirety.

BACKGROUND

[0002] Oxalic acid, the smallest dicarboxylic acid, frequently appears in nature both as a useful secondary metabolite and also a byproduct of catabolic processes. Plants produce and accumulate large quantities of oxalate as a way to poison herbivores and prevent predation.

Several metabolic processes also generate oxalate inside the bodies of mammals. Toxic oxalate must be disposed of, and in mammals this is done by transport of oxalate into the urine and feces. However, if too much oxalate is disposed of into the urine, hyperoxaluria can occur.

[0003] Hyperoxaluria is the condition of excreting excess oxalate in the urine. Elevated urinary oxalate has been linked to recurrent calcium oxalate kidney stones, kidney damage, and eventually end-stage renal disease. Hyperoxaluria is categorized into four classes by the major source of the excess oxalate: primary, enteric, dietary, and idiopathic hyperoxaluria. Primary hyperoxaluria concerns hyperoxaluria where the causes are genetic; its three forms, I, II, and III, are caused by mutations in the human genes AGXT, GRHPR, and HOGA1, respectively.

Mutations in any of these genes result in increased levels of oxalate generated by endogenous processes in the liver. The forms of hyperoxaluria where a genetic cause cannot be established– enteric, dietary, and idiopathic hyperoxaluria– are termed secondary hyperoxaluria. While some baseline level of absorption of oxalate from the diet is normal, in patients with enteric hyperoxaluria the permeability of the intestine to oxalate has been increased, causing greater absorption of oxalate from the diet. This can be caused by disrupted gut physiology from conditions including inflammatory bowel disease and gastric bypass. Dietary hyperoxaluria stems from an overconsumption of oxalate or oxalate precursors in the diet. Finally, for patients with idiopathic hyperoxaluria an acute cause of their hyperoxaluria has not been identified. [0004] Few treatments for hyperoxaluria exist. For primary hyperoxaluria patients with a mutation in AXGT, pyridoxine can be prescribed to salvage some activity of the mutated enzyme. Alternatively, primary hyperoxaluria patients can receive a liver transplant to replace missing liver enzymes. For the remainder of hyperoxaluria patients, a high-calcium, low-oxalate diet is the primary intervention, along with other treatments aimed at correcting complications - kidney stones and renal failure. However, oxalate is difficult to avoid even with careful dieting, and instructing patients to avoid oxalate is most often insufficient. With such limited treatments available to mitigate hyperoxaluria, patients need a powerful, stable treatment to remove oxalate from their bodies.

[0005] Accordingly, there is an ongoing need for new and effective therapies for treating and managing diseases or disorders associated with an elevated amount of oxalate such as hyperoxaluria.

BRIEF SUMMARY

[0006] The disclosure relates generally to a bacterium that has been modified to have increased oxalate degrading activity. Disclosed bacteria are useful for treating disorders associated with an elevated amount of oxalate in a subject, e.g., hyperoxaluria.

[0007] For example, in one aspect, provided herein is a commensal bacterium that has been modified to have increased oxalate degrading activity relative to a similar or otherwise identical bacterium that has not been modified. In certain embodiments, a similar or otherwise identical bacterium that has not been modified has no detectable oxalate degrading activity and/or has no genes known to be involved, e.g., directly involved, in oxalate catabolism. In certain

embodiments, no naturally occurring member of the same genus as the bacterium has detectable oxalate degrading activity.

[0008] In certain embodiments, a contemplated bacterium is of a genus selected from the group consisting of Bacteroides, Alistipes, Faecalibacterium, Parabacteroides, Prevotella, Roseburia, Ruminococcus, Clostridium, Oscillibacter, Gemmiger, Barnesiella, Dialister, Parasutterella, Phascolarctobacterium, Propionibacterium, Sutterella, Blautia, Paraprevotella, Coprococcus, Odoribacter, Spiroplasma, Anaerostipes, and Akkermansia. For example, a contemplated bacterium may be of the Bacteroides genus, i.e., may be a Bacteroides species bacterium. [0009] In certain embodiments, a contemplated bacterium comprises one or more transgenes encoding a protein, or a functional fragment or variant thereof, selected from the group consisting of: an oxalate:formate antiporter (OxlT); an oxalate decarboxylase (OXDC) - EC 4.1.1.2; an oxalate oxidase (OXO) - EC 1.2.3.4; an oxalate oxidoreductase (OOR) - EC 1.2.7.10; an oxalate-CoA ligase / Oxalyl-CoA synthetase (OXS) - EC 6.2.1.8; a formyl-CoA:oxalate CoA- transferase (FCOCT) - EC 2.8.3.16; an acetyl-CoA:oxalate CoA-transferase (ACOCT) - EC 2.8.3.19; a succinyl-CoA:oxalate CoA-transferase (SCOCT) - EC 2.8.3.2; an oxalyl-CoA decarboxylase (OXC) - EC 4.1.1.8; an oxalyl-CoA reductase / glyoxylate:NADP+

oxidoreductase (OXR) - EC 1.2.1.17; and a combination of any of the foregoing proteins. It is contemplated that the one or more transgenes may, e.g., be on a plasmid, bacterial artificial chromosome, or be genomically integrated. When a bacterium comprises one or more transgenes encoding multiple proteins, it is contemplated that the open reading frames encoding two or more of the proteins may, e.g., be present in a single operon.

[0010] In certain embodiments, a contemplated bacterium comprises one or more transgenes encoding an OxIT or a functional fragment or variant thereof, an OXS or a functional fragment or variant thereof, and an OXC or a functional fragment or variant thereof. In certain

embodiments, a bacterium further comprises one or more transgenes encoding a FCOCT or a functional fragment or variant thereof and/or an ACOCT or a functional fragment or variant thereof.

[0011] In certain embodiments, a contemplated bacterium comprises one or more transgenes encoding an OxIT or a functional fragment or variant thereof, an OXS or a functional fragment or variant thereof, a first OXC or a functional fragment or variant thereof, a second OXC or a functional fragment or variant thereof, a FCOCT or a functional fragment or variant thereof, and/or an ACOCT or a functional fragment or variant thereof. In certain embodiments, a contemplated bacterium comprises one or more transgenes encoding an OxIT or a functional fragment or variant thereof, a first OXS or a functional fragment or variant thereof, a second OXS or a functional fragment or variant thereof, an OXC or a functional fragment or variant thereof, a FCOCT or a functional fragment or variant thereof, and/or an ACOCT or a functional fragment or variant thereof. In certain embodiments, a contemplated bacterium comprises one or more transgenes encoding an OxIT or a functional fragment or variant thereof a first OXS or a functional fragment or variant thereof, a second OXS or a functional fragment or variant thereof, a first OXC or a functional fragment or variant thereof, a second OXC or a functional fragment or variant thereof, a FCOCT or a functional fragment or variant thereof, and/or an ACOCT or a functional fragment or variant thereof.

[0012] In certain embodiments, a contemplated bacterium comprises one or more transgenes encoding an O. formigenes OxIT; a S. cerevisiae or an A. thaliana OXS; a S. cerevisiae or an O. formigenes OXC; an E. coli FCOCT; and/or an E. coli ACOCT. For example, it is contemplated that a bacterium may comprise: (i) one or more transgenes encoding a S. cerevisiae OXS, a S. cerevisiae OXC, and an O. formigenes OxIT; (ii) one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, and an O. formigenes OxIT; (iii) one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, a S. cerevisiae OXC, an E. coli ACOCT, and an O. formigenes OxIT; (iv) or one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, a S. cerevisiae OXC, an A. thaliana OXS, an E. coli ACOCT, and an O. formigenes OxIT; (v) one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, an O. formigenes OxIT, an E. coli ACOCT, and a S. cerevisiae OXS; (vi) one or more transgenes encoding an O. formigenes OxIT, an E. coli FCOCT, a S. cerevisiae OXC, an E. coli ACOCT, a S. cerevisiae OXS, and an A. thaliana OXS; or (vii) one or more transgenes encoding an O. formigenes OxIT, an E. coli FCOCT, a S.

cerevisiae OXC, an E. coli ACOCT, and a S. cerevisiae OXS.

[0013] In certain embodiments, a contemplated bacterium comprises one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to any one of SEQ ID NOs: 1-31, or comprising the nucleotide sequence of any one of SEQ ID NOs: 1-31.

[0014] For example, a contemplated bacterium may comprise: (i) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 16, a nucleotide sequence having at least 80% identity to SEQ ID NO: 26 or SEQ ID NO: 163, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 21; (ii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 7, a nucleotide sequence having at least 80% identity to SEQ ID NO: 25, a nucleotide sequence having at least 80% identity to SEQ ID NO: 16, and a nucleotide sequence having at least 80% identity to SEQ

ID NO: 21 ; (iii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 7, a nucleotide sequence having at least 80% identity to SEQ ID NO: 25, a nucleotide sequence having at least 80% identity to SEQ ID NO: 16, a nucleotide sequence having at least 80% identity to SEQ ID NO: 26 or SEQ ID NO: 163, a nucleotide sequence having at least 80% identity to SEQ ID NO: 2, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 21; (iv) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 7, a nucleotide sequence having at least 80% identity to SEQ ID NO: 25, a nucleotide sequence having at least 80% identity to SEQ ID NO: 16, a nucleotide sequence having at least 80% identity to SEQ ID NO: 26 or SEQ ID NO: 163, a nucleotide sequence having at least 80% identity to SEQ ID NO: 14, a nucleotide sequence having at least 80% identity to SEQ ID NO: 2, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 21; (v) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 7, a nucleotide sequence having at least 80% identity to SEQ ID NO: 25, a nucleotide sequence having at least 80% identity to SEQ ID NO: 21, a nucleotide sequence having at least 80% identity to SEQ ID NO: 2, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 16; (vi) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 21, a nucleotide sequence having at least 80% identity to SEQ ID NO: 7, a nucleotide sequence having at least 80% identity to SEQ ID NO: 26 or SEQ ID NO: 163, a nucleotide sequence having at least 80% identity to SEQ ID NO: 2, a nucleotide sequence having at least 80% identity to SEQ ID NO: 16, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 14; or (vii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 21, a nucleotide sequence having at least 80% identity to SEQ ID NO: 7, a nucleotide sequence having at least 80% identity to SEQ ID NO: 26 or SEQ ID NO: 163, a nucleotide sequence having at least 80% identity to SEQ ID NO: 2, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 16.

[0015] For example, a contemplated bacterium may comprise: (i) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 16, SEQ ID NO: 26 or SEQ ID NO: 163, and SEQ ID NO: 21; (ii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 16, and SEQ ID NO: 21; (iii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 16, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 2, and SEQ ID NO: 21 ; (iv) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 16, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 14, SEQ ID NO: 2, and SEQ ID NO: 21; (v) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 21, SEQ ID NO: 2, and SEQ ID NO: 16; (vi) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 21, SEQ ID NO: 7, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 2, SEQ ID NO: 16, and SEQ ID NO: 14; or (vii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 21, SEQ ID NO: 7, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 2, and SEQ ID NO: 16.

[0016] In certain embodiments, a transgene or nucleic acid is operably linked to a ribosome binding site (RBS). Exemplary RBSs include those comprising the nucleotide sequence of any one of SEQ ID NOs: 164-230. For example, a contemplated bacterium may comprise: (i) a transgene encoding an O. formigenes OxIT operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 212-219; (ii) a transgene encoding a S. cerevisiae OXS operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 172- 179; (iii) a transgene encoding an A. thaliana OXS operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 164-171; (iv) a transgene encoding a S.

cerevisiae OXC operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 188-195 or 220-230; (v) a transgene encoding an O. formigenes OXC operably linked to an RBS comprising the nucleotide sequence of any one of ID NOs: 180-187; (vi) a transgene encoding an E. coli FCOCT operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 204-211; and/or (vii) transgene encoding an E. coli ACOCT operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 196-203.

[0017] In certain embodiments, a contemplated bacterium comprises one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to any one of SEQ ID NOs: 96- 162, or comprising the nucleotide sequence of any one of SEQ ID NOs: 96-162.

[0018] For example, a contemplated bacterium may comprise: (i) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 113, a nucleotide sequence having at least 80% identity to SEQ ID NO: 145, a nucleotide sequence having at least 80% identity to SEQ ID NO: 128, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 104; (ii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 155, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 128, a nucleotide sequence having at least 80% identity to SEQ ID NO: 148, a nucleotide sequence having at least 80% identity to SEQ ID NO: 115, a nucleotide sequence having at least 80% identity to SEQ ID NO: 98, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 105; (iii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 155, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 128, a nucleotide sequence having at least 80% identity to SEQ ID NO: 144, a nucleotide sequence having at least 80% identity to SEQ ID NO: 115, a nucleotide sequence having at least 80% identity to SEQ ID NO: 98, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 105; (iv) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 147, a nucleotide sequence having at least 80% identity to SEQ ID NO: 104, a nucleotide sequence having at least 80% identity to SEQ ID NO: 153, a nucleotide sequence having at least 80% identity to SEQ ID NO: 97, a nucleotide sequence having at least 80% identity to SEQ ID NO: 131, a nucleotide sequence having at least 80% identity to SEQ ID NO: 136, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 113; (v) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 145, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 153, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, a nucleotide sequence having at least 80% identity to SEQ ID NO: 105, a nucleotide sequence having at least 80% identity to SEQ ID NO: 113, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 96; (vi) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 145, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 153, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, a nucleotide sequence having at least 80% identity to SEQ ID NO: 105, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 96; (vii) one or NO: 139, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, a nucleotide sequence having at least 80% identity to SEQ ID NO: 155, a nucleotide sequence having at least 80% identity to SEQ ID NO: 112, a nucleotide sequence having at least 80% identity to SEQ ID NO: 99, a nucleotide sequence having at least 80% identity to SEQ ID NO: 106, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 145; (viii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 139, a nucleotide sequence having at least 80% identity to SEQ ID NO: 154, a nucleotide sequence having at least 80% identity to SEQ ID NO: 131, a nucleotide sequence having at least 80% identity to SEQ ID NO: 98, a nucleotide sequence having at least 80% identity to SEQ ID NO: 115, a nucleotide sequence having at least 80% identity to SEQ ID NO: 106, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 149; (ix) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 113, a nucleotide sequence having at least 80% identity to SEQ ID NO: 148, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 105; (x) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 145, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 153, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 105; (xi) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 155, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 128, a nucleotide sequence having at least 80% identity to SEQ ID NO: 144, a nucleotide sequence having at least 80% identity to SEQ ID NO: 115, a nucleotide sequence having at least 80% identity to SEQ ID NO: 98, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 105; (xii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 145, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 153, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, a nucleotide sequence having at least 80% identity to SEQ ID NO: 105, a nucleotide sequence having at least 80% identity to SEQ ID NO: 113, and a acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 145, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 153, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, a nucleotide sequence having at least 80% identity to SEQ ID NO: 105, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 96; or (xiv) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 139, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, a nucleotide sequence having at least 80% identity to SEQ ID NO: 155, a nucleotide sequence having at least 80% identity to SEQ ID NO: 112, a nucleotide sequence having at least 80% identity to SEQ ID NO: 99, a nucleotide sequence having at least 80% identity to SEQ ID NO: 106, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 145.

[0019] For example, a contemplated bacterium may comprise: (i) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 137, SEQ ID NO: 113, SEQ ID NO: 145, SEQ ID NO: 128, and SEQ ID NO: 104; (ii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 155, SEQ ID NO: 137, SEQ ID NO: 128, SEQ ID NO: 148, SEQ ID NO: 115, SEQ ID NO: 98, and SEQ ID NO: 105; (iii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 155, SEQ ID NO: 137, SEQ ID NO: 128, SEQ ID NO: 144, SEQ ID NO: 115, SEQ ID NO: 98, and SEQ ID NO: 105; (iv) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 147, SEQ ID NO: 104, SEQ ID NO: 153, SEQ ID NO: 97, SEQ ID NO: 131, SEQ ID NO: 136, and SEQ ID NO: 113; (v) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, SEQ ID NO: 113, and SEQ ID NO: 96; (vi) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, and SEQ ID NO: 96; (vii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 139, SEQ ID NO: 129, SEQ ID NO: 155, SEQ ID NO: 112, SEQ ID NO: 99, SEQ ID NO: 106, and SEQ ID NO: 145; (viii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 139, SEQ ID NO: 154, SEQ ID NO: 131, SEQ ID NO: 98, SEQ ID NO: 115, SEQ ID NO: 106, and SEQ ID NO: 149; (ix) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 137, SEQ ID NO: 113, SEQ ID NO: 148, SEQ ID NO: 129, and SEQ ID NO: 105; (x) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, and SEQ ID NO: 105; (xi) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 155, SEQ ID NO: 137, SEQ ID NO: 128, SEQ ID NO: 144, SEQ ID NO: 115, SEQ ID NO: 98, and SEQ ID NO: 105; (xii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, SEQ ID NO: 113, and SEQ ID NO: 96; (xiii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, and SEQ ID NO: 96; or (xiv) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 139, SEQ ID NO: 129, SEQ ID NO: 155, SEQ ID NO: 112, SEQ ID NO: 99, SEQ ID NO: 106, and SEQ ID NO: 145.

[0020] In certain embodiments, a contemplated bacterium comprises one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to any one of SEQ ID NOs: 82- 95, or comprising the nucleotide sequence of any one of SEQ ID NOs: 82-95.

[0021] In certain embodiments, a transgene or nucleic acid is operably linked to at least one constitutive promoter, e.g., a phage-derived promoter. Exemplary promoters include those comprising the consensus sequence GTTAA(n)4-7GTTAA(n)34-38TA(n)2TTTG (SEQ ID: 70), or comprising SEQ ID NO: 68, SEQ ID NO: 69, or SEQ ID NO: 71.

[0022] In certain embodiments, a contemplated bacterium has been modified to colonize the human gut with increased abundance, stability, predictability or ease of initial colonization relative to a similar or otherwise identical bacterium that has not been modified. For example, a contemplated bacterium may be modified to increase its ability to utilize a privileged nutrient as carbon source. For example, a contemplated bacterium may comprise one or more transgenes that increase its ability to utilize a privileged nutrient as carbon source. Exemplary privileged nutrients include, e.g., a marine polysaccharide, e.g., a porphyran. A disclosed bacterium may, e.g., upon administration to a human subject, result in an abundance greater than 10 ¹² , 10 ¹¹ , 10 ¹⁰ , 10 ⁹ , 10 ⁸ , or 10 ⁷ cfu per gram of fecal content.

[0023] In another aspect, provided herein is a pharmaceutical composition comprising a disclosed bacterium and a pharmaceutically acceptable excipient. In certain embodiments, a contemplated pharmaceutical composition is formulated as a capsule or tablet, e.g., an enteric coated capsule. In certain embodiments, a contemplated pharmaceutical composition further comprises a privileged nutrient, e.g., a marine polysaccharide, e.g., a porphyran.

[0024] In another aspect, provided herein is a method of reducing oxalate in a subject in need thereof. A contemplated method comprises administering to the subject an effective amount of a disclosed bacterium or pharmaceutical composition. In certain embodiments, a subject has a disorder associated with an elevated amount of oxalate, e.g., hyperoxaluria. In another aspect, provided herein is a method of treating a disorder associated with an elevated amount of oxalate in a subject, e.g., hyperoxaluria. A contemplated method comprises administering to the subject an effective amount of a disclosed bacterium or pharmaceutical composition.

[0025] Contemplated methods may comprise administration of a disclosed bacterium or pharmaceutical composition to a subject every 12 hours, 24 hours, day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, week, 2 weeks, 3 weeks, 4 weeks, month, 2 months, 3 months, 4 months, 5 months, or 6 months. In certain embodiments, the time between consecutive administrations of a disclosed bacterium or pharmaceutical composition to a subject is greater than 48 hours.

[0026] Contemplated methods may further comprise administrating a privileged nutrient to the subject, e.g., a marine polysaccharide, e.g., a porphyran. For example, a disclosed privileged nutrient may be administered to the subject prior to, at the same time as, or after a disclosed bacterium.

[0027] In another aspect, the invention provides an expression vector encoding a protein, or a functional fragment or variant thereof, selected from the group consisting of: an oxalate:formate antiporter (OxlT); an oxalate decarboxylase (OXDC) - EC 4.1.1.2; an oxalate oxidase (OXO) - EC 1.2.3.4; an oxalate oxidoreductase (OOR) - EC 1.2.7.10; an oxalate-CoA ligase / Oxalyl-CoA synthetase (OXS) - EC 6.2.1.8; a formyl-CoA:oxalate CoA-transferase (FCOCT) - EC 2.8.3.16; an acetyl-CoA:oxalate CoA-transferase (ACOCT) - EC 2.8.3.19; a succinyl-CoA:oxalate CoA- transferase (SCOCT) - EC 2.8.3.2; an oxalyl-CoA decarboxylase (OXC) - EC 4.1.1.8; an oxalyl- CoA reductase / glyoxylate:NADP+ oxidoreductase (OXR) - EC 1.2.1.17; and a combination of any of the foregoing proteins. Exemplary expression vectors include, e.g., a plasmid, and a bacterial artificial chromosome. When an expression vector comprises one or more transgenes encoding multiple proteins, it is contemplated that the open reading frames encoding two or more of the proteins may, e.g., be present in a single operon.

[0028] In certain embodiments, a contemplated expression vector comprises one or more transgenes encoding an OxIT or a functional fragment or variant thereof, an OXS or a functional fragment or variant thereof, and an OXC or a functional fragment or variant thereof. In certain embodiments, an expression vector further comprises one or more transgenes encoding a FCOCT or a functional fragment or variant thereof and/or an ACOCT or a functional fragment or variant thereof.

[0029] In certain embodiments, a contemplated expression vector comprises one or more transgenes encoding an OxIT or a functional fragment or variant thereof, an OXS or a functional fragment or variant thereof, a first OXC or a functional fragment or variant thereof, a second OXC or a functional fragment or variant thereof, a FCOCT or a functional fragment or variant thereof, and/or an ACOCT or a functional fragment or variant thereof. In certain embodiments, a contemplated expression vector comprises one or more transgenes encoding an OxIT or a functional fragment or variant thereof, a first OXS or a functional fragment or variant thereof, a second OXS or a functional fragment or variant thereof, an OXC or a functional fragment or variant thereof, a FCOCT or a functional fragment or variant thereof, and/or an ACOCT or a functional fragment or variant thereof. In certain embodiments, a contemplated expression vector comprises one or more transgenes encoding an OxIT or a functional fragment or variant thereof, a first OXS or a functional fragment or variant thereof, a second OXS or a functional fragment or variant thereof, a first OXC or a functional fragment or variant thereof, a second OXC or a functional fragment or variant thereof, a FCOCT or a functional fragment or variant thereof, and/or an ACOCT or a functional fragment or variant thereof.

[0030] In certain embodiments, a contemplated expression vector comprises one or more transgenes encoding an O. formigenes OxIT; a S. cerevisiae or an A. thaliana OXS; a S.

cerevisiae or an O. formigenes OXC; an E. coli FCOCT; and/or an E. coli ACOCT. For example, it is contemplated that an expression vector may comprise: (i) one or more transgenes encoding a S. cerevisiae OXS, a S. cerevisiae OXC, and an O. formigenes OxIT; (ii) one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, and an O. formigenes OxIT ; (iii) one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, a S. cerevisiae OXC, an E. coli ACOCT, and an O.

formigenes OxIT; (iv) or one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, a S. cerevisiae OXC, an A. thaliana OXS, an E. coli ACOCT, and an O. formigenes OxIT; (v) one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, an O. formigenes OxIT, an E. coli ACOCT, and a S. cerevisiae OXS; (vi) one or more transgenes encoding an O. formigenes OxIT, an E. coli FCOCT, a S. cerevisiae OXC, an E. coli ACOCT, a S. cerevisiae OXS, and an A. thaliana OXS; or (vii) one or more transgenes encoding an O. formigenes OxIT, an E. coli FCOCT, a S. cerevisiae OXC, an E. coli ACOCT, and a S. cerevisiae OXS.

[0031] In certain embodiments, a contemplated expression vector comprises one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to any one of SEQ ID NOs: 1-31, or comprising the nucleotide sequence of any one of SEQ ID NOs: 1-31.

[0032] For example, a contemplated expression vector may comprise: (i) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 16, a nucleotide sequence having at least 80% identity to SEQ ID NO: 26 or SEQ ID NO: 163, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 21; (ii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 7, a nucleotide sequence having at least 80% identity to SEQ ID NO: 25, a nucleotide sequence having at least 80% identity to SEQ ID NO: 16, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 21; (iii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 7, a nucleotide sequence having at least 80% identity to SEQ ID NO: 25, a nucleotide sequence having at least 80% identity to SEQ ID NO: 16, a nucleotide sequence having at least 80% identity to SEQ ID NO: 26 or SEQ ID NO: 163, a nucleotide sequence having at least 80% identity to SEQ ID NO: 2, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 21; (iv) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 7, a nucleotide sequence having at least 80% identity to SEQ ID NO: 25, a nucleotide sequence having at least 80% identity to SEQ ID NO: 16, a nucleotide sequence having at least 80% identity to SEQ ID NO: 26 or SEQ ID NO: 163, a nucleotide sequence having at least 80% identity to SEQ ID NO: 14, a nucleotide sequence having at least 80% identity to SEQ ID NO: 2 and a nucleotide sequence having at least 80% identity to SEQ ID NO: 21; (v) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 7, a nucleotide sequence having at least 80% identity to SEQ ID NO: 25, a nucleotide sequence having at least 80% identity to SEQ ID NO: 21, a nucleotide sequence having at least 80% identity to SEQ ID NO: 2, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 16; (vi) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 21, a nucleotide sequence having at least 80% identity to SEQ ID NO: 7, a nucleotide sequence having at least 80% identity to SEQ ID NO: 26 or SEQ ID NO: 163, a nucleotide sequence having at least 80% identity to SEQ ID NO: 2, a nucleotide sequence having at least 80% identity to SEQ ID NO: 16, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 14; or (vii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 21, a nucleotide sequence having at least 80% identity to SEQ ID NO: 7, a nucleotide sequence having at least 80% identity to SEQ ID NO: 26 or SEQ ID NO: 163, a nucleotide sequence having at least 80% identity to SEQ ID NO: 2, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 16.

[0033] For example, a contemplated expression vector may comprise: (i) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 16, SEQ ID NO: 26 or SEQ ID NO: 163, and SEQ ID NO: 21; (ii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 16, and SEQ ID NO: 21; (iii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 16, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 2, and SEQ ID NO: 21; (iv) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 16, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 14, SEQ ID NO: 2, and SEQ ID NO: 21; (v) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 21, SEQ ID NO: 2, and SEQ ID NO: 16; (vi) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 21, SEQ ID NO: 7, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 2, SEQ ID NO: 16, and SEQ ID NO: 14; or (vii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 21, SEQ ID NO: 7, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 2, and SEQ ID NO: 16. [0034] In certain embodiments, a transgene or nucleic acid is operably linked to a ribosome binding site (RBS). Exemplary RBSs include those comprising the nucleotide sequence of any one of SEQ ID NOs: 164-230. For example, a contemplated expression vector may comprise: (i) a transgene encoding an O. formigenes OxIT operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 212-219; (ii) a transgene encoding a S.

cerevisiae OXS operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 172-179; (iii) a transgene encoding an A. thaliana OXS operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 164-171; (iv) a transgene encoding a S. cerevisiae OXC operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 188-195 or 220-230; (v) a transgene encoding an O. formigenes OXC operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 180- 187; (vi) a transgene encoding an E. coli FCOCT operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 204-211; and/or (vii) transgene encoding an E. coli ACOCT operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 196-203.

[0035] In certain embodiments, a contemplated expression vector comprises one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to any one of SEQ ID NOs: 96-162, or comprising the nucleotide sequence of any one of SEQ ID NOs: 96-162.

[0036] For example, a contemplated expression vector may comprise: (i) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 113, a nucleotide sequence having at least 80% identity to SEQ ID NO: 145, a nucleotide sequence having at least 80% identity to SEQ ID NO: 128, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 104; (ii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 155, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 128, a nucleotide sequence having at least 80% identity to SEQ ID NO: 148, a nucleotide sequence having at least 80% identity to SEQ ID NO: 115, a nucleotide sequence having at least 80% identity to SEQ ID NO: 98, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 105; (iii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 155, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 128, a nucleotide sequence having at least 80% identity to SEQ ID NO: 144, a nucleotide sequence having at least 80% identity to SEQ ID NO: 115, a nucleotide sequence having at least 80% identity to SEQ ID NO: 98, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 105; (iv) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 147, a nucleotide sequence having at least 80% identity to SEQ ID NO: 104, a nucleotide sequence having at least 80% identity to SEQ ID NO: 153, a nucleotide sequence having at least 80% identity to SEQ ID NO: 97, a nucleotide sequence having at least 80% identity to SEQ ID NO: 131, a nucleotide sequence having at least 80% identity to SEQ ID NO: 136, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 113; (v) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 145, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 153, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, a nucleotide sequence having at least 80% identity to SEQ ID NO: 105, a nucleotide sequence having at least 80% identity to SEQ ID NO: 113, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 96; (vi) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 145, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 153, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, a nucleotide sequence having at least 80% identity to SEQ ID NO: 105, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 96; (vii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 139, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, a nucleotide sequence having at least 80% identity to SEQ ID NO: 155, a nucleotide sequence having at least 80% identity to SEQ ID NO: 112, a nucleotide sequence having at least 80% identity to SEQ ID NO: 99, a nucleotide sequence having at least 80% identity to SEQ ID NO: 106, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 145; (viii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 139, a nucleotide sequence having at least 80% identity to SEQ ID NO: 154, a nucleotide sequence having at least 80% identity to SEQ ID NO: 131, a nucleotide sequence having at least NO: 115, a nucleotide sequence having at least 80% identity to SEQ ID NO: 106, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 149; (ix) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 113, a nucleotide sequence having at least 80% identity to SEQ ID NO: 148, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 105; (x) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 145, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 153, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 105; (xi) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 155, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 128, a nucleotide sequence having at least 80% identity to SEQ ID NO: 144, a nucleotide sequence having at least 80% identity to SEQ ID NO: 115, a nucleotide sequence having at least 80% identity to SEQ ID NO: 98, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 105; (xii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 145, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 153, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, a nucleotide sequence having at least 80% identity to SEQ ID NO: 105, a nucleotide sequence having at least 80% identity to SEQ ID NO: 113, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 96; (xiii) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 145, a nucleotide sequence having at least 80% identity to SEQ ID NO: 137, a nucleotide sequence having at least 80% identity to SEQ ID NO: 153, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, a nucleotide sequence having at least 80% identity to SEQ ID NO: 105, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 96; or (xiv) one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to SEQ ID NO: 139, a nucleotide sequence having at least 80% identity to SEQ ID NO: 129, a nucleotide sequence having at least 80% identity to SEQ ID NO: 155, a nucleotide sequence having at least NO: 99, a nucleotide sequence having at least 80% identity to SEQ ID NO: 106, and a nucleotide sequence having at least 80% identity to SEQ ID NO: 145.

[0037] For example, a contemplated expression vector may comprise: (i) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 137, SEQ ID NO: 113, SEQ ID NO: 145, SEQ ID NO: 128, and SEQ ID NO: 104; (ii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 155, SEQ ID NO: 137, SEQ ID NO: 128, SEQ ID NO: 148, SEQ ID NO: 115, SEQ ID NO: 98, and SEQ ID NO: 105; (iii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 155, SEQ ID NO: 137, SEQ ID NO: 128, SEQ ID NO: 144, SEQ ID NO: 115, SEQ ID NO: 98, and SEQ ID NO: 105; (iv) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 147, SEQ ID NO: 104, SEQ ID NO: 153, SEQ ID NO: 97, SEQ ID NO: 131, SEQ ID NO: 136, and SEQ ID NO: 113; (v) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, SEQ ID NO: 113, and SEQ ID NO: 96; (vi) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, and SEQ ID NO: 96; (vii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 139, SEQ ID NO: 129, SEQ ID NO: 155, SEQ ID NO: 112, SEQ ID NO: 99, SEQ ID NO: 106, and SEQ ID NO: 145; (viii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 139, SEQ ID NO: 154, SEQ ID NO: 131, SEQ ID NO: 98, SEQ ID NO: 115, SEQ ID NO: 106, and SEQ ID NO: 149; (ix) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 137, SEQ ID NO: 113, SEQ ID NO: 148, SEQ ID NO: 129, and SEQ ID NO: 105; (x) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, and SEQ ID NO: 105; (xi) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 155, SEQ ID NO: 137, SEQ ID NO: 128, SEQ ID NO: 144, SEQ ID NO: 115, SEQ ID NO: 98, and SEQ ID NO: 105; (xii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, SEQ ID NO: 113, and SEQ ID NO: 96; (xiii) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, and SEQ ID NO: 96; or (xiv) one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 139, SEQ ID NO: 129, SEQ ID NO: 155, SEQ ID NO: 112, SEQ ID NO: 99, SEQ ID NO: 106, and SEQ ID NO: 145.

[0038] In certain embodiments, a contemplated expression vector comprises one or more nucleic acids comprising a nucleotide sequence having at least 80% identity to any one of SEQ ID NOs: 82-95, or comprising the nucleotide sequence of any one of SEQ ID NOs: 82-95.

[0039] In certain embodiments, a transgene or nucleic acid is operably linked to at least one constitutive promoter, e.g., a phage-derived promoter. Exemplary promoters include those comprising the consensus sequence GTTAA(n) _4-7 GTTAA(n) _34-38 TA(n) ₂ TTTG (SEQ ID: 70), or comprising SEQ ID NO: 68, SEQ ID NO: 69, or SEQ ID NO: 71.

[0040] These and other aspects and features of the disclosure are described in the following detailed description and claims.

DESCRIPTION OF THE DRAWINGS

[0041] The disclosure can be more completely understood with reference to the following drawings.

[0042] FIGURE 1 is a schematic depicting pathways for oxalate degradation. Oxalate is imported into bacterial cells using the OxIT oxalate:formate antiporter and then converted into formate, glyoxylate, or CO ₂ via a variety of different pathways. The most productive pathway uses OXS, FCOCT, ACOCT, or SCOCT to conjugate oxalate to CoA to make oxalyl-CoA, and then OXC to decarboxylate oxalyl-CoA into formyl-CoA. FCOCT is then used to release formate and restart the cycle.

[0043] FIGURE 2 is a pie chart showing bacterial abundance in the average human gut based on 16S ribosomal DNA sequencing. Bacteroides is the most abundant genus at 46%.

[0044] FIGURE 3 depicts a schematic representation of five different plasmids (SEQ ID NOs: 63-67) which can be conjugated into Bacteroides to yield oxalate-degrading Bacteroides strains.

[0045] FIGURE 4 is a bar graph depicting the amount of oxalate consumed by Bacteroides vulgatus ATCC 8482 with either no transgenes (wildtype), or with genomic integration of the following plasmids: pZR748 (SEQ ID NO: 63), pZR753 (SEQ ID NO: 64), pZR753 + pZR761 (SEQ ID NOs: 64 65) or pZR856 + pZR878 (SEQ ID NOs: 66 67) Overnight cultures of each Bacteroides strain were diluted 1:10 into fresh BHIS liquid media supplemented with 10 or 30 mM oxalate, and oxalate consumption rates were monitored over 48 hours.

[0046] FIGURE 5 depicts a schematic representation of plasmid pWD035 (SEQ ID NO: 73), a bacterial artificial chromosome bearing a conjugative transfer origin and a porphyran polysaccharide utilization locus (PUL).

[0047] FIGURE 6 depicts an in vitro growth assay of Bacteroides vulgatus cells that received a functional porphyran PUL (pWD035, SEQ ID NO: 73) compared to wildtype B. vulgatus cells. Saturated cultures were diluted 50X into minimal media supplemented with 0.2% porphyran and grown anaerobically for 14 hours at 37˚C. Optical density of the cultures was monitored throughout. Only the cells that contained the porphyran PUL were capable of growth on porphyran.

[0048] FIGURE 7 depicts three different plasmids (SEQ ID NOs: 75-77) harboring oxalate- consumption genes. Each plasmid was conjugated into the porphyran-utilizing strain NB075 to yield strains that could consume both a privileged nutrient, porphyran, and a gut-derived toxin, oxalate.

[0049] FIGURE 8 is a line graph depicting the rate of oxalate consumption for the indicated engineered Bacteroides strains following addition of the strains at 10 ¹⁰ cfu/ml to fresh BHIS media containing 4mM oxalate.

[0050] FIGURE 9 is a line graph depicting the rate of oxalate consumption for the indicated engineered Bacteroides strains following addition of the strains at 10 ¹⁰ cfu/ml to cecal contents from Sprague-Dawley rats containing 4mM oxalate.

[0051] FIGURE 10 is a bar graph depicting urine oxalate levels in a rat model of secondary hyperoxaluria following treatment with the indicated strain. Relative to a non-oxalate-consuming control strain (NB075), the oxalate-consuming strain sWW152 yields a 32% reduction in urine oxalate 4-6 days after strain administration (p=0.005). Error bars represent 95% confidence intervals.

[0052] FIGURE 11 is a line graph depicting urine oxalate levels in a rat model of secondary hyperoxaluria following treatment with the indicated strain. Relative to a non-oxalate-consuming control strain (NB124), the oxalate-consuming strain sWW554 yields a 46% reduction in urine oxalate 4-6 days after strain administration (p=0.0003). Shaded regions represent 95% confidence intervals.

[0053] FIGURE 12 is a bar graph depicting the fecal abundance of each strain from day 12 of the experiment summarized in FIGURE 11.

[0054] FIGURE 13A is a bar graph depicting strain abundance (measured by colony forming units (CFU) per gram feces) in a rat model of secondary hyperoxaluria following treatment with the indicated strain and the indicated amount (% by weight) of porphyran administered in the drinking water. FIGURE 13B is a bar graph depicting urine oxalate levels in a rat model of secondary hyperoxaluria following treatment with the indicated strain and the indicated amount (% by weight) of porphyran administered in the drinking water. Bars represent mean, points represent individual animals, and error bars represent 95% confidence intervals.

[0055] FIGURE 14 is a bar graph depicting urine oxalate levels in rats with hyperoxaluria induced via Route-en-Y Gastric Bypass (RYGB) surgery following treatment with the indicated strain. Bars represent the final five-consecutive-day average of total daily urine oxalate of the rats in each group. Error bars represent the 95% confidence intervals (n = 5 sham rats, n = 8 for all other groups).

[0056] FIGURE 15A depicts results from screening of ribosome binding sites (RBSs). Each point represents expression (as measured by log10 luminescence values) for each indicated gene with a different engineered RBS, as described in Example 8. FIGURE 15B depicts expression (as measured by luminescence) of the indicated gene with the indicated RBS. Error bars represent the 95% confidence intervals.

[0057] FIGURE 16 is a bar graph depicting in vitro oxalate degradation by the indicated strains. Error bars represent the 95% confidence intervals.

DETAILED DESCRIPTION

[0058] The human gut, specifically the colon, is known to be permeable to oxalate. It functions as the primary site of absorption of dietary oxalate, and it is thought that secretion of oxalate out of the bloodstream and into the intestinal lumen provides a secondary route for elimination of oxalate from the body. Thus, the colon is an attractive location for a system to degrade oxalate, preventing absorption of dietary oxalate and reabsorption of secreted endogenous oxalate.

[0059] The disclosure relates generally to bacteria that have been modified to have increased oxalate degrading activity. For example, in one aspect, provided herein is a commensal bacterium that has been modified to have increased oxalate degrading activity relative to a similar or otherwise identical bacterium that has not been modified. It is contemplated that disclosed bacteria may, upon administration to a subject, break down oxalate in the subject, e.g., in the large intestine of the subject, and therefore be useful for treating a disorder associated with an elevated amount of oxalate in the subject, e.g., hyperoxaluria. Accordingly, the disclosure further relates to pharmaceutical compositions or units and methods of using disclosed bacteria to treat disorders associated with an elevated amount of oxalate, e.g., hyperoxaluria.

[0060] A contemplated modified bacteria may additionally have the ability to utilize a carbon source, such as the marine polysaccharide porphyrin, that other bacteria in the gut of a subject to be treated are largely unable to utilize. As a result, the proliferation, abundance, or stability of the modified bacteria in the gut of the subject may be maintained by supplying it with the carbon source.

I. Modified Bacteria

[0061] The disclosure relates generally to bacteria that have been modified to have increased oxalate degrading activity relative to a similar or otherwise identical bacterium that has not been modified. For example, a contemplated bacterium may be modified to express one or more transgenes that increase oxalate degrading activity. The term“oxalate degrading” is used interchangeably with the term“oxalate consuming” herein. Pathways for oxalate degradation, including genes related to oxalate degradation, are depicted in FIGURE 1. It is contemplated that the one or more transgenes may, e.g., be on a plasmid, bacterial artificial chromosome, or be genomically integrated. When a bacterium comprises one or more transgenes encoding multiple proteins, it is contemplated that the open reading frames encoding two or more of the proteins may, e.g., be present in a single operon. [0062] Exemplary genes related to oxalate degradation, the expression of which in a bacterium may increase oxalate degrading activity, include those encoding: an oxalate:formate antiporter (OxlT); an oxalate decarboxylase (OXDC) - EC 4.1.1.2; an oxalate oxidase (OXO) - EC 1.2.3.4; an oxalate oxidoreductase (OOR) - EC 1.2.7.10; an oxalate-CoA ligase / Oxalyl-CoA synthetase (OXS) - EC 6.2.1.8; a formyl-CoA:oxalate CoA-transferase (FCOCT) - EC 2.8.3.16; an acetyl- CoA:oxalate CoA-transferase (ACOCT) - EC 2.8.3.19; a succinyl-CoA:oxalate CoA-transferase (SCOCT) - EC 2.8.3.2; an oxalyl-CoA decarboxylase (OXC) - EC 4.1.1.8; and an oxalyl-CoA reductase / glyoxylate:NADP+ oxidoreductase (OXR) - EC 1.2.1.17.

[0063] In order for a bacterium to degrade oxalate, expression of an oxalate transporter may be required, typically an oxalate:formate antiporter. Exemplary oxalate transporters include OxlT from Oxalobacter formigenes or any of its homologs from other species including Cupriavidus oxalaticus, and Bifidobacterium animalis subsp. lactis. These antiporters bring oxalate into the bacterial cell from the intestinal environment, and, in exchange, expel one molecule of formate waste for every molecule of oxalate brought in. Once the oxalate gets into the cell, it can be directly degraded using oxalate decarboxylase (OXDC)– EC 4.1.1.2, oxalate oxidase (OXO)– EC 1.2.3.4, or oxalate oxidoreductase (OOR)– EC 1.2.7.10.

[0064] Alternatively, the oxalate can be conjugated to coenzyme A to make oxalyl-CoA using either oxalate--CoA ligase (OXS)– EC 6.2.1.8, formyl-CoA:oxalate CoA-transferase (FCOCT) – EC 2.8.3.16, acetyl-CoA:oxalate CoA-transferase (ACOCT)– EC 2.8.3.19, or succinyl- CoA:oxalate CoA-transferase (SCOCT)– EC 2.8.3.2. FCOCT uses formyl-CoA as a CoA donor, and as formyl-CoA is generated as a waste product during oxalyl-CoA degradation, results in an efficient cycle. It may also be necessary to start the cycle using more abundant starting material such as ATP, acetyl-CoA, or succinyl-CoA, used by OXS, ACOCT, and SCOCT respectively.

[0065] Oxalyl-CoA is broken down by oxalyl-CoA decarboxylase (OXC)– EC 4.1.1.8. This in turn generates formyl-CoA, which is degraded by FCOCT to release formate. Then formate can be degraded by formate dehydrogenase (FDH)– EC 1.2.1.2 to generate CO ₂ . An additional option for oxalyl-CoA disposal is reduction into glyoxylate for constructing additional biomass via oxalyl-CoA reductase (OXR) / Glyoxylate:NADP+ oxidoreductase– EC 1.2.1.17. [0066] In certain embodiments of a contemplated modified bacterium, oxalate is imported into the bacterium using an OxlT antiporter and fed into a continuous cycle of oxalate to formate conversion using FCOCT and OXC. Further support for this cycle can be provided by increased expression of multiple copies of OXC enzymes. Additionally, the pool of cycle intermediates, oxalyl-CoA and formyl-CoA, can be created and supported by expression of OXS, ACOCT, or SCOCT. Thus, in certain embodiments, a contemplated bacterial cell has high, multicopy expression of OXC and FCOCT, high expression of OXS, ACOCT, and/or SCOCT, and moderate expression of OxlT. In certain embodiments, an N-terminal fragment of an oxalate:formate antiporter has been swapped with an N-terminal fragment from a native transporter protein.

[0067] Accordingly, in certain embodiments, a contemplated bacterium comprises one or more transgenes encoding an OxIT or a functional fragment or variant thereof, an OXS or a functional fragment or variant thereof, and an OXC or a functional fragment or variant thereof. In certain embodiments, a bacterium further comprises one or more transgenes encoding a FCOCT or a functional fragment or variant thereof and/or an ACOCT or a functional fragment or variant thereof.

[0068] In certain embodiments, a contemplated bacterium comprises one or more transgenes encoding an OxIT or a functional fragment or variant thereof, an OXS or a functional fragment or variant thereof, a first OXC or a functional fragment or variant thereof, a second OXC or a functional fragment or variant thereof, a FCOCT or a functional fragment or variant thereof, and/or an ACOCT or a functional fragment or variant thereof. In certain embodiments, a contemplated bacterium comprises one or more transgenes encoding an OxIT or a functional fragment or variant thereof, a first OXS or a functional fragment or variant thereof, a second OXS or a functional fragment or variant thereof, an OXC or a functional fragment or variant thereof, a FCOCT or a functional fragment or variant thereof, and/or an ACOCT or a functional fragment or variant thereof. In certain embodiments, a contemplated bacterium comprises one or more transgenes encoding an OxIT or a functional fragment or variant thereof, a first OXS or a functional fragment or variant thereof, a second OXS or a functional fragment or variant thereof, a first OXC or a functional fragment or variant thereof, a second OXC or a functional fragment or variant thereof, a FCOCT or a functional fragment or variant thereof, and/or an ACOCT or a functional fragment or variant thereof.

[0069] As used herein, the term“functional fragment” of a biological entity (e.g., a gene, protein (e.g. ,OxIT, OXS, OXC, or FCOCT), promoter, or ribosome binding site) refers to a fragment of the full-length biological entity that retains, for example, at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or 100% of the biological activity of the corresponding full-length, naturally occurring biologically entity.

[0070] In certain embodiments, a contemplated bacterium comprises one or more transgenes encoding a B. animalis subsp. lactis OxIT, e.g., a B. animalis subsp. lactis DSM 10140 OxIT, a C. oxalaticus OxIT, e.g., a C. oxalaticus ATCC 11883 OxIT, an E. coli OxIT, e.g., an E. coli MG1655 OxIT, an O. formigenes OxIT, e.g., an O. formigenes DSM 4420 OxIT, or a functional fragment or variant of any of the foregoing proteins. For example, in certain embodiments, a contemplated bacterium comprises one or more transgenes encoding an O. formigenes OxIT, e.g., an O. formigenes DSM 4420 OxIT, or a protein having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to an O. formigenes OxIT.

[0071] In certain embodiments, a contemplated bacterium comprises one or more transgenes encoding a S. cerevisiae OXS, e.g., a S. cerevisiae S288C OXS, a M. extorquens OXS, e.g., a M. extorquens AM1 / DSM 1338 OXS, an A. thaliana OXS, e.g., an A. thaliana col-1 OXS, or a functional fragment or variant of any of the foregoing proteins. For example, in certain embodiments, a contemplated bacterium comprises one or more transgenes encoding a S.

cerevisiae OXS, e.g., a S. cerevisiae S288C OXS, or a protein having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to a S. cerevisiae OXS. In certain embodiments, a contemplated bacterium comprises one or more transgenes encoding an A. thaliana OXS, e.g., an A. thaliana col-1 OXS, or a protein having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to an A. thaliana OXS.

[0072] In certain embodiments, a contemplated bacterium comprises one or more transgenes encoding a B. animalis subsp. lactis OXC, e.g., a B. animalis subsp. lactis DSM 10140 OXC, a C. oxalaticus OXC, e.g., a C. oxalaticus ATCC 11883 OXC, an E. coli OXC, e.g., an E. coli MG1655 OXC, a S. cerevisiae OXC, e.g., a S. cerevisiae S288C OXC, an O. formigenes OXC, e.g., an O. formigenes DSM 4420 OXC, or a functional fragment or variant of any of the foregoing proteins. For example, in certain embodiments, a contemplated bacterium comprises one or more transgenes encoding a S. cerevisiae OXC, e.g., a S. cerevisiae S288C OXC, or a protein having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%,

96%, 97%, 98%, or 99% identity to a S. cerevisiae OXC. In certain embodiments a contemplated bacterium comprises one or more transgenes encoding an O. formigenes OXC, e.g., an O.

formigenes DSM 4420 OXC, or a protein having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to an O. formigenes OXC.

[0073] In certain embodiments, a contemplated bacterium comprises one or more transgenes encoding a B. animalis subsp. lactis FCOCT, e.g., a B. animalis subsp. lactis DSM 10140 FCOCT, a C. oxalaticus FCOCT, e.g., a C. oxalaticus ATCC 11883 FCOCT, an E. coli FCOCT, e.g., an E. coli MG1655 FCOCT, an O. formigenes FCOCT, e.g., an O. formigenes DSM 4420 FCOCT, or a functional fragment or variant of any of the foregoing proteins. For example, in certain embodiments, a contemplated bacterium comprises one or more transgenes encoding an E. coli FCOCT, e.g., an E. coli MG1655 FCOCT, or a protein having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to an E. coli FCOCT.

[0074] In certain embodiments, a contemplated bacterium comprises one or more transgenes encoding an A. aceti ACOCT, e.g., an A. aceti strain 1023 ACOCT, an E. coli ACOCT, e.g., an E. coli MG1655 ACOCT, or a functional fragment or variant of any of the foregoing proteins. For example, in certain embodiments, a contemplated bacterium comprises one or more transgenes encoding an E. coli ACOCT, e.g., an E. coli MG1655 ACOCT, or a protein having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to an E. coli ACOCT.

[0075] For example, it is contemplated that a bacterium may comprise: (i) one or more transgenes encoding a S. cerevisiae OXS, a S. cerevisiae OXC, and an O. formigenes OxIT, or a functional fragment or variant of any of the foregoing proteins; (ii) one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, and an O. formigenes OxIT, or a functional fragment or variant of any of the foregoing proteins; (iii) one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, a S.

cerevisiae OXC, an E. coli ACOCT, and an O. formigenes OxIT, or a functional fragment or variant of any of the foregoing proteins; (iv) one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, a S. cerevisiae OXC, an A. thaliana OXS, an E. coli ACOCT, and an O. formigenes OxIT, or a functional fragment or variant of any of the foregoing proteins; (v) one or more transgenes encoding an E. coli FCOCT, an O. formigenes OXC, an O. formigenes OxIT, an E. coli ACOCT, and a S. cerevisiae OXS, or a functional fragment or variant of any of the foregoing proteins; (vi) one or more transgenes encoding an O. formigenes OxIT, an E. coli FCOCT, a S. cerevisiae OXC, an E. coli ACOCT, a S. cerevisiae OXS, and an A. thaliana OXS, or a functional fragment or variant of any of the foregoing proteins; or (vii) one or more transgenes encoding an O. formigenes OxIT, an E. coli FCOCT, a S. cerevisiae OXC, an E. coli ACOCT, and a S. cerevisiae OXS, or a functional fragment or variant of any of the foregoing proteins.

[0076] Exemplary ACOCT coding sequences are depicted in SEQ ID NOs: 1-2, exemplary FDH coding sequences are depicted in SEQ ID NOs: 3-4, exemplary FCOCT coding sequences are depicted in SEQ ID NOs: 4-8, an exemplary OXDC coding sequence is depicted in SEQ ID NO: 9, an exemplary OXO coding sequence is depicted in SEQ ID NO: 10, exemplary OOR coding sequence are depicted in SEQ ID NOs: 11-13, exemplary OXS coding sequences are depicted in SEQ ID NOs: 14-16, exemplary OxIT coding sequences are depicted in SEQ ID NOs: 17-21, exemplary OXC coding sequences are depicted in SEQ ID NOs: 22-26 and 163, an exemplary OXR coding sequence is depicted in SEQ ID NO: 27, and exemplary SCOCT coding sequences are depicted in SEQ ID NOs: 28-31.

[0077] Accordingly, in certain embodiments, a bacterium has been modified to comprise one or more nucleic acids comprising a nucleotide sequence of any one of SEQ ID NOs: 1-31, or a functional fragment or variant thereof. In certain embodiments, a bacterium has been modified to comprise one or more nucleic acids comprising a nucleotide sequence having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to any one of SEQ ID NOs: 1-31, or a functional fragment or variant thereof. [0078] For example, it is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 16, SEQ ID NO: 26 or SEQ ID NO: 163, and SEQ ID NO: 21, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 16, SEQ ID NO: 26 or SEQ ID NO: 163, and SEQ ID NO: 21. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 16, and SEQ ID NO: 21, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 16, and SEQ ID NO: 21. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 16, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 2, and SEQ ID NO: 21, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 16, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 2, and SEQ ID NO: 21. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 16, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 14, SEQ ID NO: 2, and SEQ ID NO: 21, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 16, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 14, SEQ ID NO: 2, and SEQ ID NO: 21. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 21, SEQ ID NO: 2, and SEQ ID NO: 16, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 7, SEQ ID NO: 25, SEQ ID NO: 21, SEQ ID NO: 2, and SEQ ID NO: 16. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 21, SEQ ID NO: 7, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 2, SEQ ID NO: 16, and SEQ ID NO: 14, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 21, SEQ ID NO: 7, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 2, SEQ ID NO: 16, and SEQ ID NO: 14. It nucleotide sequences of SEQ ID NO: 21, SEQ ID NO: 7, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 2, and SEQ ID NO: 16, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 21, SEQ ID NO: 7, SEQ ID NO: 26 or SEQ ID NO: 163, SEQ ID NO: 2, and SEQ ID NO: 16.

[0079] In certain embodiments, a bacterium has been modified to comprise one or more nucleic acids comprising a nucleotide sequence encoding an amino acid sequence of any one of SEQ ID NOs: 32-62, or a functional fragment or variant thereof. In certain embodiments, a bacterium has been modified to comprise one or more nucleic acids comprising a nucleotide sequence encoding an amino acid sequence having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to any one of SEQ ID NOs: 32-62, or a functional fragment or variant thereof.

[0080] For example, it is contemplated that a bacterium may comprise one or more nucleic acids comprising one or more nucleotide sequences encoding the amino acid sequences of SEQ ID NO: 47, SEQ ID NO: 57, and SEQ ID NO: 52, or amino acid sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 47, SEQ ID NO: 57, and SEQ ID NO: 52. It is contemplated that a bacterium may comprise one or more nucleic acids comprising one or more nucleotide sequences encoding the amino acid sequences of SEQ ID NO: 38, SEQ ID NO: 56, SEQ ID NO: 47, and SEQ ID NO: 52, or amino acid sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 38, SEQ ID NO: 56, SEQ ID NO: 47, and SEQ ID NO: 52. It is contemplated that a bacterium may comprise one or more nucleic acids comprising one or more nucleotide sequences encoding the amino acid sequences of SEQ ID NO: 38, SEQ ID NO: 56, SEQ ID NO: 47, SEQ ID NO: 57, SEQ ID NO: 33, and SEQ ID NO: 52, or amino acid sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 38, SEQ ID NO: 56, SEQ ID NO: 47, SEQ ID NO: 57, SEQ ID NO: 33, and SEQ ID NO: 52. It is contemplated that a bacterium may comprise one or more nucleic acids comprising one or more nucleotide sequences encoding the amino acid sequences of SEQ ID NO: 38, SEQ ID NO: 56, SEQ ID NO: 47 SEQ ID NO: 57 SEQ ID NO: 45 SEQ ID NO: 33 and SEQ ID NO: 52 or amino acid sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 38, SEQ ID NO: 56, SEQ ID NO: 47, SEQ ID NO: 57, SEQ ID NO: 45, SEQ ID NO: 33, and SEQ ID NO: 52. It is contemplated that a bacterium may comprise one or more nucleic acids comprising one or more nucleotide sequences encoding the amino acid sequences of SEQ ID NO: 38, SEQ ID NO: 56, SEQ ID NO: 52, SEQ ID NO: 33, and SEQ ID NO: 47, or amino acid sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 38, SEQ ID NO: 56, SEQ ID NO: 52, SEQ ID NO: 33, and SEQ ID NO: 47. It is contemplated that a bacterium may comprise one or more nucleic acids comprising one or more nucleotide sequences encoding the amino acid sequences of SEQ ID NO: 52, SEQ ID NO: 38, SEQ ID NO: 57, SEQ ID NO: 33, SEQ ID NO: 47, and SEQ ID NO: 45, or amino acid having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 52, SEQ ID NO: 38, SEQ ID NO: 57, SEQ ID NO: 33, SEQ ID NO: 47, and SEQ ID NO: 45. It is contemplated that a bacterium may comprise one or more nucleic acids comprising one or more nucleotide sequences encoding the amino acid sequences of SEQ ID NO: 52, SEQ ID NO: 38, SEQ ID NO: 57, SEQ ID NO: 33, and SEQ ID NO: 47, or amino acid sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 52, SEQ ID NO: 38, SEQ ID NO: 57 SEQ ID NO: 33, and SEQ ID NO: 47.

[0081] Sequence identity may be determined in various ways that are within the skill in the art, e.g., using publicly available computer software such as BLAST, BLAST-2, ALIGN or

Megalign (DNASTAR) software. BLAST (Basic Local Alignment Search Tool) analysis using the algorithm employed by the programs blastp, blastn, blastx, tblastn and tblastx (Karlin et al., (1990) P ^ROC . N ^ATL . A ^CAD . S ^CI . USA 87:2264-2268; Altschul, (1993) J. M ^OL . E ^VOL .36, 290- 300; Altschul et al., (1997) NUCLEIC ACIDS RES.25:3389-3402, incorporated by reference) are tailored for sequence similarity searching. For a discussion of basic issues in searching sequence databases see Altschul et al., (1994) NATURE GENETICS 6:119-129, which is fully incorporated by reference. Those skilled in the art can determine appropriate parameters for measuring alignment, including any algorithms needed to achieve maximal alignment over the full length of the sequences being compared. The search parameters for histogram, descriptions, alignments, expect (i.e., the statistical significance threshold for reporting matches against database sequences), cutoff, matrix and filter are at the default settings. The default scoring matrix used by blastp, blastx, tblastn, and tblastx is the BLOSUM62 matrix (Henikoff et al., (1992) PROC. NATL. ACAD. SCI. USA 89:10915-10919, fully incorporated by reference). Four blastn parameters may be adjusted as follows: Q=10 (gap creation penalty); R=10 (gap extension penalty); wink=1 (generates word hits at every wink.sup.th position along the query); and gapw=16 (sets the window width within which gapped alignments are generated). The equivalent Blastp parameter settings may be Q=9; R=2; wink=1; and gapw=32. Searches may also be conducted using the NCBI (National Center for Biotechnology Information) BLAST Advanced Option parameter (e.g.: -G, Cost to open gap [Integer]: default = 5 for nucleotides/ 11 for proteins; -E, Cost to extend gap [Integer]: default = 2 for nucleotides/ 1 for proteins; -q, Penalty for nucleotide mismatch [Integer]: default = -3; -r, reward for nucleotide match [Integer]: default = 1; -e, expect value [Real]: default = 10; -W, wordsize [Integer]: default = 11 for nucleotides/ 28 for megablast/ 3 for proteins; -y, Dropoff (X) for blast extensions in bits: default = 20 for blastn/ 7 for others; -X, X dropoff value for gapped alignment (in bits): default = 15 for all programs, not applicable to blastn; and–Z, final X dropoff value for gapped alignment (in bits): 50 for blastn, 25 for others). ClustalW for pairwise protein alignments may also be used (default parameters may include, e.g., Blosum62 matrix and Gap Opening Penalty = 10 and Gap Extension Penalty = 0.1). A Bestfit comparison between sequences, available in the GCG package version 10.0, uses DNA parameters GAP=50 (gap creation penalty) and LEN=3 (gap extension penalty) and the equivalent settings in protein comparisons are GAP=8 and LEN=2.

[0082] A contemplated modified bacterium, for example, for use in a disclosed pharmaceutical composition or method, includes a bacterium of genus Bacteroides, Alistipes, Faecalibacterium, Parabacteroides, Prevotella, Roseburia, Ruminococcus, Clostridium, Oscillibacter, Gemmiger, Barnesiella, Dialister, Parasutterella, Phascolarctobacterium, Propionibacterium, Sutterella, Blautia, Paraprevotella, Coprococcus, Odoribacter, Spiroplasma, Anaerostipes, or

Akkermansia. A contemplated bacterium, for example, for use in a disclosed pharmaceutical composition or method, may be of the Bacteroides genus, i.e., may be a Bacteroides species bacterium. [0083] Exemplary Bacteroides species include B. acidifaciens, B. barnesiaes, B. caccae, B. caecicola, B. caecigallinarum, B. cellulosilyticus, B. cellulosolvens, B. clarus, B. coagulans, B. coprocola, B. coprophilus, B. coprosuis, B. distasonis, B. dorei, B. eggerthii, B. gracilis, B. faecichinchillae, B. faecis, B. finegoldii, B. fluxus, B. fragilis, B. galacturonicus, B. gallinaceum, B. gallinarum, B. goldsteinii, B. graminisolvens, B. helcogene, B. intestinalis, B. luti, B.

massiliensis, B. melaninogenicus, B. nordii, B. oleiciplenus, B. oris, B. ovatus, B.

paurosaccharolyticus, B. pectinophilus, B. plebeius, B. polypragmatus, B. propionicifaciens, B. putredinis, B. pyogenes, B. reticulotermitis, B. rodentium, B. salanitronis, B. salyersiae, B.

sartorii, B. sediment B. stercoris, B. suis, B. tectus, B. thetaiotaomicron, B. uniformis, B.

vulgatus, B. xylanisolvens, and B. xylanolyticusxylanolyticus.

[0084] As used herein, the term“species” refers to a taxonomic entity as conventionally defined by genomic sequence and phenotypic characteristics. A“strain” is a particular instance of a species that has been isolated and purified according to conventional microbiological techniques. The present disclosure encompasses derivatives of the disclosed bacterial strains. The term “derivative” includes daughter strains (progeny) or stains cultured (sub-cloned) from the original but modified in some way (including at the genetic level), without altering negatively a biological activity of the strain.

[0085] In certain embodiments, a contemplated modified bacterium is of a genus that makes up more than 0.1%, 0.5%, 1%, 5%, 10%, 20%, 30%, or 40% of the total culturable microbes in the feces of a subject to be treated, or in the feces of an average human. In certain embodiments, a contemplated modified bacterium is of a genus that is detected at a level greater than 10 ¹² , 10 ¹¹ , 10 ¹⁰ , 10 ⁹ , 10 ⁸ , 10 ⁷ colony forming units per gram of feces of a subject to be treated, or per gram of feces of an average human. In certain embodiments, a contemplated modified bacterium is of a genus that makes up more than 0.1%, 0.5%, 1%, 5%, 10%, 20%, 30%, or 40% of the gut microbiome of a subject to be treated, or of the gut microbiome of an average human. Human gut or feces microbiome composition may be assayed by any technique known in the art, including 16S ribosomal sequencing. FIGURE 2 shows bacterial abundance in the average human gut based on 16S ribosomal DNA sequencing. Bacteroides is the most naturally abundant genus in the human gut. [0086] rRNA, 16S rDNA, 16S rRNA, 16S, 18S, 18S rRNA, and 18S rDNA refer to nucleic acids that are components of, or encode for, components of the ribosome. There are two subunits in the ribosome termed the small subunit (SSU) and large subunit (LSU). rDNA genes and their complementary RNA sequences are widely used for determination of the evolutionary relationships amount organisms as they are variable, yet sufficiently conserved to allow cross- organism molecular comparisons.

[0087] 16S rDNA sequence (approximately 1542 nucleotides in length) of the 30S SSU can be used, in certain embodiments, for molecular-based taxonomic assignments of prokaryotes and the 18S rDNA sequence (approximately 1869 nucleotides in length) of 40S SSU may be used for eukaryotes. For example, 16S sequences may be used for phylogenetic reconstruction as they are general highly conserved but contain specific hypervariable regions that harbor sufficient nucleotide diversity to differentiate genera and species of most bacteria. Although 16S rDNA sequence data has been used to provide taxonomic classification, closely related bacterial strains that are classified within the same genus and species, may exhibit distinct biological phenotypes.

[0088] The identity of contemplated bacterial species or strains may be characterized by 16S rRNA or full genome sequence analysis. For example, in certain embodiments, contemplated bacterial strains may comprise a 16S rRNA or genomic sequence having a certain % identity to a reference sequence.

[0089] In certain embodiments, a contemplated modified bacterium is capable of stably colonizing the human gut. A disclosed bacterium may, e.g., upon administration to a human subject, result in an abundance greater than 10 ¹² , 10 ¹¹ , 10 ¹⁰ , 10 ⁹ , 10 ⁸ , or 10 ⁷ cfu per gram of fecal content. For example, administration of about 10 ³ , about 10 ⁴ , about 10 ⁵ , about 10 ⁶ , about 10 ⁷ , about 10 ⁸ , about 10 ⁹ , about 10 ¹⁰ , about 10 ¹¹ , or about 10 ¹² cells of a disclosed bacterium to a human subject may result in an abundance greater than 10 ¹² , 10 ¹¹ , 10 ¹⁰ , 10 ⁹ , 10 ⁸ , or 10 ⁷ cfu per gram of fecal content with 12 hours, 24 hours, 36 hours, 48 hours, 60 hours, or 72 hours of administration.

[0090] A disclosed bacterium may, e.g., have been modified to colonize the human gut with increased abundance, stability, predictability or ease of initial colonization relative to a similar or otherwise identical bacterium that has not been modified. For example, a contemplated bacterium may be modified to increase its ability to utilize a privileged nutrient as carbon source. A“privileged nutrient” is defined as a molecule or set of molecules that can be consumed to aid in the proliferation of a particular bacterial strain while providing proliferation assistance to no more than 1% of the other bacteria in the gut. Accordingly, in certain embodiments, a modified bacterium has the ability to consume the privileged nutrient to sustain its colonization and expand in the gut of a subject to a predictably high abundance, even in the absence of oxalate or other carbon or energy sources, while most other bacteria in the gut of the subject do not.

Exemplary privileged nutrients include, e.g., a marine polysaccharide, e.g., a porphyran.

[0091] For example, a bacterium may comprise one or more transgenes that increase its ability to utilize a privileged nutrient, e.g., a marine polysaccharide, e.g., a porphyrin, as carbon source. In certain embodiments, a bacterium may comprise all or a portion of a polysaccharide utilization locus (PUL), a mobile genetic element that confers the ability to consume a carbohydrate, e.g., a privileged nutrient, upon a bacterium. An exemplary porphyran consumption PUL is the PUL from the porphyran-consuming Bacteroides strain NB001 depicted in SEQ ID NO: 72.

Accordingly, in certain embodiments, a modified bacterium comprises SEQ ID NO: 72, or a functional fragment or variant thereof. In certain embodiments, a modified bacterium comprises a nucleotide sequence having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 72, or a functional fragment or variant thereof.

[0092] Additional exemplary bacterial modifications to increase abundance in the gut of a subject, privileged nutrients, transgenes that increase the ability of a bacteria to utilize a privileged nutrient, PULs, and other methods and compositions for modulating the growth of a modified bacterium are described in International (PCT) Patent Publication No. WO2018112194.

[0093] In certain embodiments, a similar or otherwise identical bacterium that has not been modified has no detectable oxalate degrading activity and/or has no genes known to be involved e.g. , directly involved, in oxalate catabolism. For example, a similar or otherwise identical bacterium that has not been modified may have no genes encoding: an oxalate:formate antiporter (OxlT); an oxalate decarboxylase (OXDC) - EC 4.1.1.2; an oxalate oxidase (OXO) - EC 1.2.3.4; an oxalate oxidoreductase (OOR) - EC 1.2.7.10; an oxalate-CoA ligase / Oxalyl-CoA synthetase

(OXS) - EC 6.2.1.8; a formyl-CoA:oxalate CoA-transferase (FCOCT) - EC 2.8.3.16; an acetyl- CoA:oxalate CoA-transferase (ACOCT) - EC 2.8.3.19; a succinyl-CoA:oxalate CoA-transferase (SCOCT) - EC 2.8.3.2; an oxalyl-CoA decarboxylase (OXC) - EC 4.1.1.8; or an oxalyl-CoA reductase / glyoxylate:NADP+ oxidoreductase (OXR) - EC 1.2.1.17. In certain embodiments, no naturally occurring member of the same genus as the bacterium has detectable oxalate degrading activity.

[0094] In certain embodiments, a disclosed transgene or nucleic acid comprising an exogenous nucleotide sequence is operably linked to at least one constitutive promoter, e.g., a phage-derived promoter. The term "operably linked" refers to a linkage of polynucleotide elements in a functional relationship. A nucleic acid sequence is "operably linked" when it is placed into a functional relationship with another nucleic acid sequence. For instance, a promoter or enhancer is operably linked to a gene if it affects the transcription of the gene. Operably linked nucleotide sequences are typically contiguous. However, as enhancers generally function when separated from the promoter by several kilobases and intronic sequences may be of variable lengths, some polynucleotide elements may be operably linked but not directly flanked and may even function in trans from a different allele or chromosome. Exemplary phage-derived promoters include those comprising the nucleotide sequence of SEQ ID NO: 68, SEQ ID NO: 69, SEQ ID NO: 70, or SEQ ID NO: 71, or a nucleotide sequence having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 68, SEQ ID NO: 69, SEQ ID NO: 70, or SEQ ID NO: 71. Additional exemplary phage-derived promoters are described in International (PCT) Patent Publication No. WO2017184565.

[0095] In certain embodiments, a disclosed transgene or nucleic acid comprising an exogenous nucleotide sequence is operably linked to at least one ribosome binding site (RBS). Exemplary RBSs include those comprising the nucleotide sequence of any one of SEQ ID NOs: 164-230, a nucleotide sequence having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to any one of SEQ ID NOs: 164-230, or a functional fragment or variant of any of the foregoing nucleotide sequences. For example, a contemplated bacterium may comprise: (i) a transgene encoding an O. formigenes OxIT operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 212-219, a nucleotide sequence having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94% 95% 96% 97% 98% or 99% identity to any one of SEQ ID NOs: 212-219 or a functional fragment or variant of any of the foregoing nucleotide sequences; (ii) a transgene encoding a S. cerevisiae OXS operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 172-179, a nucleotide sequence having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to any one of SEQ ID NOs: 172-179, or a functional fragment or variant of any of the foregoing nucleotide sequences; (iii) a transgene encoding an A. thaliana OXS operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 164-171, a nucleotide sequence having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to any one of SEQ ID NOs: 164-171, or a functional fragment or variant of any of the foregoing nucleotide sequences; (iv) a transgene encoding a S. cerevisiae OXC operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 188-195 or 220-230, a nucleotide sequence having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to any one of SEQ ID NOs: 188-195 or 220-230, or a functional fragment or variant of any of the foregoing nucleotide sequences; (v) a transgene encoding an O. formigenes OXC operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 180-187, a nucleotide sequence having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to any one of SEQ ID NOs: 180-187, or a functional fragment or variant of any of the foregoing nucleotide sequences; (vi) a transgene encoding an E. coli FCOCT operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 204-211, a nucleotide sequence having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to any one of SEQ ID NOs: 204-211, or a functional fragment or variant of any of the foregoing nucleotide sequences; and/or (vii) transgene encoding an E. coli ACOCT operably linked to an RBS comprising the nucleotide sequence of any one of SEQ ID NOs: 196- 203, a nucleotide sequence having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to any one of SEQ ID NOs: 196-203, or a functional fragment or variant of any of the foregoing nucleotide sequences.

[0096] It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequence of any one of SEQ ID NOs: 96-162, or a nucleotide sequence having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to the nucleotide sequence of any one of SEQ ID NOs: 96-162.

[0097] For example, it is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 137, SEQ ID NO: 113, SEQ ID NO: 145, SEQ ID NO: 128, and SEQ ID NO: 104, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 137, SEQ ID NO: 113, SEQ ID NO: 145, SEQ ID NO: 128, and SEQ ID NO: 104. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 155, SEQ ID NO: 137, SEQ ID NO: 128, SEQ ID NO: 148, SEQ ID NO: 115, SEQ ID NO: 98, and SEQ ID NO: 105, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 155, SEQ ID NO: 137, SEQ ID NO: 128, SEQ ID NO: 148, SEQ ID NO: 115, SEQ ID NO: 98, and SEQ ID NO: 105. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 155, SEQ ID NO: 137, SEQ ID NO: 128, SEQ ID NO: 144, SEQ ID NO: 115, SEQ ID NO: 98, and SEQ ID NO: 105, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 155, SEQ ID NO: 137, SEQ ID NO: 128, SEQ ID NO: 144, SEQ ID NO: 115, SEQ ID NO: 98, and SEQ ID NO: 105. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 147, SEQ ID NO: 104, SEQ ID NO: 153, SEQ ID NO: 97, SEQ ID NO: 131, SEQ ID NO: 136, and SEQ ID NO: 113, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 147, SEQ ID NO: 104, SEQ ID NO: 153, SEQ ID NO: 97, SEQ ID NO: 131, SEQ ID NO: 136, and SEQ ID NO: 113. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, SEQ ID NO: 113, and SEQ ID NO: 96, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, SEQ ID NO: 113, and SEQ ID NO: 96. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, and SEQ ID NO: 96, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, and SEQ ID NO: 96. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 139, SEQ ID NO: 129, SEQ ID NO: 155, SEQ ID NO: 112, SEQ ID NO: 99, SEQ ID NO: 106, and SEQ ID NO: 145, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 139, SEQ ID NO: 129, SEQ ID NO: 155, SEQ ID NO: 112, SEQ ID NO: 99, SEQ ID NO: 106, and SEQ ID NO: 145. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 139, SEQ ID NO: 154, SEQ ID NO: 131, SEQ ID NO: 98, SEQ ID NO: 115, SEQ ID NO: 106, and SEQ ID NO: 149, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 139, SEQ ID NO: 154, SEQ ID NO: 131, SEQ ID NO: 98, SEQ ID NO: 115, SEQ ID NO: 106, and SEQ ID NO: 149. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 137, SEQ ID NO: 113, SEQ ID NO: 148, SEQ ID NO: 129, and SEQ ID NO: 105, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 137, SEQ ID NO: 113, SEQ ID NO: 148, SEQ ID NO: 129, and SEQ ID NO: 105 It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, and SEQ ID NO: 105, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, and SEQ ID NO: 105. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 155, SEQ ID NO: 137, SEQ ID NO: 128, SEQ ID NO: 144, SEQ ID NO: 115, SEQ ID NO: 98, and SEQ ID NO: 105, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 155, SEQ ID NO: 137, SEQ ID NO: 128, SEQ ID NO: 144, SEQ comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, SEQ ID NO: 113, and SEQ ID NO: 96, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, SEQ ID NO: 113, and SEQ ID NO: 96. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, and SEQ ID NO: 96, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 145, SEQ ID NO: 137, SEQ ID NO: 153, SEQ ID NO: 129, SEQ ID NO: 105, and SEQ ID NO: 96. It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequences of SEQ ID NO: 139, SEQ ID NO: 129, SEQ ID NO: 155, SEQ ID NO: 112, SEQ ID NO: 99, SEQ ID NO: 106, and SEQ ID NO: 145, or nucleotide sequences having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to SEQ ID NO: 139, SEQ ID NO: 129, SEQ ID NO: 155, SEQ ID NO: 112, SEQ ID NO: 99, SEQ ID NO: 106, and SEQ ID NO: 145.

[0098] It is contemplated that a bacterium may comprise one or more nucleic acids comprising the nucleotide sequence of any one of SEQ ID NOs: 82-95, or a nucleotide sequence having at least 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to the nucleotide sequence of any one of SEQ ID NOs: 82-95.

II. Pharmaceutical Compositions/Units

[0099] A bacterium disclosed herein may be combined with pharmaceutically acceptable excipients to form a pharmaceutical composition, which can be administered to a patient by any means known in the art. As used herein, the term“pharmaceutically acceptable excipient” is understood to mean one or more of a buffer, carrier, or excipient suitable for administration to a subject, for example, a human subject, without excessive toxicity, irritation, allergic response, or other problem or complication, commensurate with a reasonable benefit/risk ratio. The excipient(s) should be“acceptable” in the sense of being compatible with the other ingredients of the formulations and not deleterious to the recipient. [00100] Pharmaceutically acceptable excipients include buffers, solvents, dispersion media, coatings, isotonic and absorption delaying agents, and the like, that are compatible with pharmaceutical administration. Pharmaceutically acceptable excipients also include fillers, binders, disintegrants, glidants, lubricants, and any combination(s) thereof. For further examples of excipients, carriers, stabilizers and adjuvants, see, e.g., Handbook of Pharmaceutical

Excipients, 8 ^th Ed., Edited by P.J. Sheskey, W.G. Cook, and C.G. Cable, Pharmaceutical Press, London, UK [2017]. The use of such media and agents for pharmaceutically active substances is known in the art.

[00101] Contemplated bacteria may be used in disclosed compositions in any form, e.g., a stable form, as known to those skilled in the art, including in a lyophilized state (with optionally one or more appropriate cryoprotectants), frozen (e.g., in a standard or super-cooled freezer), spray dried, and/or freeze dried. A "stable" formulation or composition is one in which the biologically active material therein essentially retains its physical stability, chemical stability, and/or biological activity upon storage. Stability can be measured at a selected temperature and humidity conditions for a selected time period. Trend analysis can be used to estimate an expected shelf life before a material has actually been in storage for that time period. For live bacteria, for example, stability may be defined as the time it takes to lose 1 log of cfu/g dry formulation under predefined conditions of temperature, humidity and time period.

[00102] A bacterium disclosed herein may be combined with one or more cryoprotectants. Exemplary cryoprotectants include fructoligosaccharides (e.g., raftilose ^® ), trehalose,

maltodextrin, sodium alginate, proline, glutamic acid, glycine (e.g., glycine betaine), mono-, di-, or polysaccharides (such as glucose, sucrose, maltose, lactose), polyols (such as mannitol, sorbitol, or glycerol), dextran, DMSO, methylcellulose, propylene glycol, polyvinylpyrrolidone, non-ionic surfactants such as Tween 80, and/or any combinations thereof.

[00103] A pharmaceutical composition should be formulated to be compatible with its intended route of administration. Contemplated bacterial compositions disclosed herein can be prepared by any suitable method and can be formulated into a variety of forms and administered by a number of different means. Contemplated compositions can be administered orally, rectally, or enterally, in formulations containing conventionally acceptable carriers, adjuvants, d hi l d i d d h i “ l d i i i ” i d d i l d administration by enema, suppository, or colonoscopy. A disclosed pharmaceutical composition may, e.g., be suitable for bolus administration or bolus release. In an exemplary embodiment, a disclosed bacterial composition is administered orally.

[00104] Solid dosage forms for oral administration include capsules, tablets, caplets, pills, troches, lozenges, powders, and granules. A capsule typically comprises a core material comprising a bacterial composition and a shell wall that encapsulates the core material. In some embodiments the core material comprises at least one of a solid, a liquid, and an emulsion. In some embodiments the shell wall material comprises at least one of a soft gelatin, a hard gelatin, and a polymer. Suitable polymers include, but are not limited to: cellulosic polymers such as hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose (HPMC), methyl cellulose, ethyl cellulose, cellulose acetate, cellulose acetate phthalate, cellulose acetate trimellitate, hydroxypropylmethyl cellulose phthalate, hydroxypropylmethyl cellulose succinate and carboxymethylcellulose sodium; acrylic acid polymers and copolymers, such as those formed from acrylic acid, methacrylic acid, methyl acrylate, ammonio methylacrylate, ethyl acrylate, methyl methacrylate and/or ethyl methacrylate (e.g., those copolymers sold under the trade name "Eudragit ^® "); vinyl polymers and copolymers such as polyvinyl pyrrolidone, polyvinyl acetate, polyvinylacetate phthalate, vinylacetate crotonic acid copolymer, and ethylene-vinyl acetate copolymers; and shellac (purified lac). In some embodiments at least one polymer functions as a taste-masking agent.

[00105] Tablets, pills, and the like can be compressed, multiply compressed, multiply layered, and/or coated. A contemplated coating can be single or multiple. In one embodiment, a contemplated coating material comprises at least one of a saccharide, a polysaccharide, and glycoproteins extracted from at least one of a plant, a fungus, and a microbe. Non-limiting examples include corn starch, wheat starch, potato starch, tapioca starch, cellulose,

hemicellulose, dextrans, maltodextrin, cyclodextrins, inulins, pectin, mannans, gum arabic, locust bean gum, mesquite gum, guar gum, gum karaya, gum ghatti, tragacanth gum, funori, carrageenans, porphyrans, agar, alginates, chitosans, or gellan gum. In some embodiments a contemplated coating material comprises a protein. In some embodiments a contemplated coating material comprises at least one of a fat and an oil. In some embodiments the at least one of a fat and an oil is high temperature melting In some embodiments the at least one of a fat and an oil is hydrogenated or partially hydrogenated. In some embodiments the at least one of a fat and an oil is derived from a plant. In some embodiments the at least one of a fat and an oil comprises at least one of glycerides, free fatty acids, and fatty acid esters. In some embodiments a contemplated coating material comprises at least one edible wax. A contemplated edible wax can be derived from animals, insects, or plants. Non-limiting examples include beeswax, lanolin, bayberry wax, carnauba wax, and rice bran wax. Tablets and pills can additionally be prepared with enteric or reverse-enteric coatings.

[00106] Alternatively, powders or granules embodying a bacterial composition disclosed herein can be incorporated into a food product. In some embodiments a contemplated food product is a drink for oral administration. Non-limiting examples of a suitable drink include water, fruit juice, a fruit drink, an artificially flavored drink, an artificially sweetened drink, a carbonated beverage, a sports drink, a liquid diary product, a shake, an alcoholic beverage, a caffeinated beverage, infant formula and so forth. Other suitable means for oral administration include aqueous and nonaqueous solutions, emulsions, suspensions and solutions and/or suspensions reconstituted from non-effervescent granules, containing at least one of suitable solvents, preservatives, emulsifying agents, suspending agents, diluents, sweeteners, coloring agents, and flavoring agents.

[00107] Pharmaceutical compositions containing a bacterium disclosed herein can be presented in a unit dosage form, i.e., a pharmaceutical unit. A composition, e.g., a

pharmaceutical unit provided herein, may include any appropriate amount of bacterium, measured either by total mass or by colony forming units of the bacteria.

[00108] For example, a disclosed pharmaceutical composition or unit may include from about 10 ³ cfus to about 10 ¹² cfus, about 10 ⁶ cfus to about 10 ¹² cfus, about 10 ⁷ cfus to about 10 ¹² cfus, about 10 ⁸ cfus to about 10 ¹² cfus, about 10 ⁹ cfus to about 10 ¹² cfus, about 10 ¹⁰ cfus to about 10 ¹² cfus, about 10 ¹¹ cfus to about 10 ¹² cfus, about 10 ³ cfus to about 10 ¹¹ cfus, about 10 ⁶ cfus to about 10 ¹¹ cfus, about 10 ⁷ cfus to about 10 ¹¹ cfus, about 10 ⁸ cfus to about 10 ¹¹ cfus, about 10 ⁹ cfus to about 10 ¹¹ cfus, about 10 ¹⁰ cfus to about 10 ¹¹ cfus, about 10 ³ cfus to about 10 ¹⁰ cfus, about 10 ⁶ cfus to about 10 ¹⁰ cfus, about 10 ⁷ cfus to about 10 ¹⁰ cfus, about 10 ⁸ cfus to about 10 ¹⁰ cfus, about 10 ⁹ cfus to about 10 ¹⁰ cfus, about 10 ³ cfus to about 10 ⁹ cfus, about 10 ⁶ cfus to about

10 ⁹ cfus, about 10 ⁷ cfus to about 10 ⁹ cfus, about 10 ⁸ cfus to about 10 ⁹ cfus, about 10 ³ cfus to about 10 ⁸ cfus, about 10 ⁶ cfus to about 10 ⁸ cfus, about 10 ⁷ cfus to about 10 ⁸ cfus, about 10 ³ cfus to about 10 ⁷ cfus, about 10 ⁶ cfus to about 10 ⁷ cfus, or about 10 ³ cfus to about 10 ⁶ cfus of each bacterial strain, or may include about 10 ³ cfus, about 10 ⁶ cfus, about 10 ⁷ cfus, about 10 ⁸ cfus, about 10 ⁹ cfus, about 10 ¹⁰ cfus, about 10 ¹¹ cfus, or about 10 ¹² cfus of bacteria.

III. Therapeutic Uses

[00109] Compositions and methods disclosed herein can be used to treat various diseases or disorders associated with an elevated amount of oxalate in a subject. As used herein,“elevated amount of oxalate in a subject” may refer to an elevated amount of oxalate in a body fluid (e.g., blood, plasma, serum, or urine), tissue and/or cell in a subject, relative to a subject without the disease or disorder. The disclosure provides a method of treating a disease or disorder associated with an elevated amount of oxalate in a subject. A contemplated method comprises

administering to the subject an effective amount of a bacterium or a pharmaceutical composition disclosed herein, either alone or in a combination with another therapeutic agent, to treat the disease or disorder associated with an elevated amount of oxalate in the subject.

[00110] An example of a disease or disorder associated with an elevated amount of oxalate is hyperoxaluria, e.g., primary, enteric, dietary, or idiopathic hyperoxaluria. Hyperoxaluria, or increased urinary oxalate levels, can be characterized in humans by urinary oxalate excretion of greater than 40 mg (approximately 440 mmol) or 30 mg per day. Exemplary clinical cutoff levels are 43 mg/day (approximately 475 mmol) for men and 32 mg/day (approximately 350 mmol) for women. Hyperoxaluria can also be defined as urinary oxalate excretion greater than 30 mg per day per gram of urinary creatinine. Persons with mild hyperoxaluria may excrete at least 30-60 (342-684 mmol) or 40-60 (456-684 mmol) mg of oxalate per day. Persons with enteric hyperoxaluria may excrete at least 80 mg of urinary oxalate per day (912 mmol), and persons with primary hyperoxaluria may excrete at least 200 mg per day (2280 mmol).

[00111] Elevated urinary oxalate has been linked to a number of health problems in the kidney, e.g., kidney stones (e.g., recurrent calcium oxalate kidney stones), nephrocalcinosis,

nephrolithiasis, kidney damage, or end-stage renal disease. Calcium oxalate may also be deposited in the urinary tract, colon, small intestine, eyes, blood vessels, joints, bones, muscles, heart and other major organs, causing damage to the same. Accordingly, additional exemplary diseases or disorders associated with an elevated amount of oxalate include kidney disorders ( e.g ., kidney stones, nephrocalcinosis, polycystic kidney disease, nephrolithiasis, or renal failure (including progressive, chronic, or end-stage renal failure)), urinary tract disorders (e.g., idiopathic urinary stone disease, or urolithiasis), gastrointestinal disorders (e.g., inflammatory bowel disease, Crohn's disease, or ulcerative colitis), pancreatic disorders (e.g., exocrine pancreatic insufficiency), joint disorders, eye disorders, liver disorders, ethylene glycol poisoning, cystic fibrosis, steatorrhoea, ileal disease, vulvodynia, cardiac conductance disorders, osteoporosis, and complications from gastric bypass or other types of gastrointestinal surgery.

[00112] As used herein,“treat”,“treating” and“treatment” mean the treatment of a disease in a subject, e.g., in a human. This includes: (a) inhibiting the disease, i.e., arresting its development; and (b) relieving the disease, i.e., causing regression of the disease state. As used herein, the terms“subject” and“patient” refer to an organism to be treated by the methods and compositions described herein. Such organisms preferably include, but are not limited to, mammals, e.g., human, a companion animal (e.g., dog, cat, or rabbit), or a livestock animal (for example, cow, sheep, pig, goat, horse, donkey, and mule, buffalo, oxen, or camel)).

[00113] It will be appreciated that the exact dosage of a pharmaceutical composition, or bacterium is chosen by an individual physician in view of the patient to be treated, in general, dosage and administration are adjusted to provide an effective amount of the bacterial agent to the patient being treated. As used herein, the "effective amount" refers to the amount necessary to elicit a beneficial or desired biological response. An effective amount can be administered in one or more administrations, applications or dosages and is not intended to be limited to a particular formulation or administration route. As will be appreciated by those of ordinary skill in this art, the effective amount of a pharmaceutical unit, pharmaceutical composition, or bacterial strain may vary depending on such factors as the desired biological endpoint, the drug to be delivered, the target tissue, the route of administration, etc. Additional factors which may be taken into account include the severity of the disease state; age, weight and gender of the patient being treated; diet, time and frequency of administration; drug combinations; reaction sensitivities; and tolerance/response to therapy.

[00114] Contemplated methods may further comprise administrating a privileged nutrient to the subject to support colonization of the bacterium. Exemplary privileged nutrients include marine polysaccharides, e.g., a porphyran. For example, a disclosed privileged nutrient may be administered to the subject prior to, at the same time as, or after a disclosed bacterium.

[00115] Methods and compositions described herein may reduce oxalate levels in a subject, e.g., in a body fluid (e.g., blood, plasma, serum, or urine), tissue and/or cell in a subject, by at least about 10%, about 20%, about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 95%, or more, relative to oxalate levels in an untreated or control subject.

[00116] Contemplated methods may comprise administration of a disclosed bacterium or pharmaceutical composition to a subject every 12 hours, 24 hours, day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, week, 2 weeks, 3 weeks, 4 weeks, month, 2 months, 3 months, 4 months, 5 months, or 6 months. In certain embodiments, the time between consecutive administrations of a disclosed bacterium or pharmaceutical composition to a subject is greater than 12 hours, 24 hours, 36 hours, 48 hours, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, 1 week, 2 weeks, 3 weeks, or 4 weeks.

[00117] In certain embodiments, a disclosed bacterium and a disclosed privileged nutrient, e.g., a marine polysaccharide, e.g., a porphyran are administered to a subject with the same frequency. For example, the bacterium and the privileged nutrient may both be administered to the subject every 12 hours, 24 hours, day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, week, 2 weeks, 3 weeks, 4 weeks, month, 2 months, 3 months, 4 months, 5 months, or 6 months. In certain embodiments, a disclosed bacterium and a disclosed privileged nutrient, e.g., a marine polysaccharide, e.g., a porphyran, are administered to a subject with a different frequency. For example, the bacterium may be administered to the subject every 12 hours, 24 hours, day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, week, 2 weeks, 3 weeks, 4 weeks, month, 2 months, 3 months, 4 months, 5 months, or 6 months, and the privileged nutrient may be administered to the subject every 12 hours, 24 hours, day, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, week, 2 weeks, 3 weeks, 4 weeks, month, 2 months, 3 months, 4 months, 5 months, or 6 months. For example, in certain embodiments, the bacterium may be administered to the subject every week, 2 weeks, 3 weeks, 4 weeks, month, 2 months, 3 months, 4 months, 5 months, or 6 months, and the privileged nutrient may be administered to the subject every 12 hours, 24 hours, day, 2 days, 3 days, 4 days, 5 days, 6 days, or 7 days. [00118] Methods and compositions described herein can be used alone or in combination with other therapeutic agents and/or modalities. The term administered“in combination,” as used herein, is understood to mean that two (or more) different treatments are delivered to the subject during the course of the subject’s affliction with the disorder, such that the effects of the treatments on the patient overlap at a point in time. In certain embodiments, the delivery of one treatment is still occurring when the delivery of the second begins, so that there is overlap in terms of administration. This is sometimes referred to herein as“simultaneous” or“concurrent delivery.” In other embodiments, the delivery of one treatment ends before the delivery of the other treatment begins. In certain embodiments of either case, the treatment is more effective because of combined administration. For example, the second treatment is more effective, e.g., an equivalent effect is seen with less of the second treatment, or the second treatment reduces symptoms to a greater extent, than would be seen if the second treatment were administered in the absence of the first treatment, or the analogous situation is seen with the first treatment. In certain embodiments, delivery is such that the reduction in a symptom, or other parameter related to the disorder is greater than what would be observed with one treatment delivered in the absence of the other. The effect of the two treatments can be partially additive, wholly additive, or greater than additive. The delivery can be such that an effect of the first treatment delivered is still detectable when the second is delivered. In certain embodiments, a side effect of a first and/or second treatment is reduced because of combined administration.

[00119] In certain embodiments, a method or composition described herein is administered in combination with one or more additional therapies. In certain embodiments, a contemplated additional therapy may include: high fluid intake; a low-salt, low-oxalate, and/or a high-calcium diet; citrate, calcium, orthophosphate, and/or pyridoxine/vitamin B6 supplementation; the enzyme oxalate decarboxylase; and/or a peptide that stimulates the secretion of oxalate from the colon.

[00120] Throughout the description, where compositions are described as having, including, or comprising specific components, or where processes and methods are described as having, including, or comprising specific steps, it is contemplated that, additionally, there are compositions of the present disclosure that consist essentially of, or consist of, the recited components, and that there are processes and methods according to the present disclosure that consist essentially of, or consist of, the recited processing steps.

[00121] In the application, where an element or component is said to be included in and/or selected from a list of recited elements or components, it should be understood that the element or component can be any one of the recited elements or components, or the element or component can be selected from a group consisting of two or more of the recited elements or components.

[00122] Further, it should be understood that elements and/or features of a composition or a method described herein can be combined in a variety of ways without departing from the spirit and scope of the present disclosure, whether explicit or implicit herein. For example, where reference is made to a particular compound, that compound can be used in various embodiments of compositions of the present disclosure and/or in methods of the present disclosure, unless otherwise understood from the context. In other words, within this application, embodiments have been described and depicted in a way that enables a clear and concise application to be written and drawn, but it is intended and will be appreciated that embodiments may be variously combined or separated without parting from the present teachings and disclosure. For example, it will be appreciated that all features described and depicted herein can be applicable to all aspects of the disclosure described and depicted herein.

[00123] It should be understood that the expression“at least one of” includes individually each of the recited objects after the expression and the various combinations of two or more of the recited objects unless otherwise understood from the context and use. The expression“and/or” in connection with three or more recited objects should be understood to have the same meaning unless otherwise understood from the context.

[00124] The use of the term“include,”“includes,”“including,”“have,” “has,”“having,” “contain,”“contains,” or“containing,” including grammatical equivalents thereof, should be understood generally as open-ended and non-limiting, for example, not excluding additional unrecited elements or steps, unless otherwise specifically stated or understood from the context.

[00125] Where the use of the term“about” is before a quantitative value, the present disclosure also includes the specific quantitative value itself, unless specifically stated otherwise. As used herein, the term“about” refers to a ±10% variation from the nominal value unless otherwise indicated or inferred.

[00126] It should be understood that the order of steps or order for performing certain actions is immaterial so long as the present disclosure remains operable. Moreover, two or more steps or actions may be conducted simultaneously.

[00127] The use of any and all examples, or exemplary language herein, for example,“such as” or“including,” is intended merely to illustrate better the present disclosure and does not pose a limitation on the scope of the disclosure unless claimed. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the present disclosure.

EXAMPLES

[00128] The following Examples are merely illustrative and are not intended to limit the scope or content of the disclosure in any way.

Example 1 - Construction Of Oxalate-Degrading Bacteroides

[00129] Adding oxalate-degradation capabilities to a member of the oxalate-naive genus Bacteroides can be accomplished by addition of transgenes from other organisms ( e.g SEQ ID NOs: 1-31). For example, a construct including expression cassettes for the expression of OxlT, OXS, and OXC can be used to achieve oxalate degradation in Bacteroides. Exemplary OxlT coding sequences are depicted in SEQ ID NOs: 17-21, exemplary OXS coding sequences are depicted in SEQ ID NOs: 14-16, and exemplary OXC coding sequences are depicted in SEQ ID NOs: 22-26. Contemplated constructs may further include expression cassettes for the expression of FCOCT, ACOCT, or SCOCT. Exemplary FCOCT coding sequences are depicted in SEQ ID NOs: 4-8, exemplary ACOCT coding sequences are depicted in SEQ ID NOs: 1-2 and exemplary SCOCT coding sequences are depicted in SEQ ID NOs: 28-31. Expression of additional copies of OXS and/or OXC may also improve oxalate degradation.

[00130] FIGURE 3 shows different plasmids (SEQ ID NOs: 63-67) which can be used individually or in combination to generate Bacteroides with oxalate degradation capabilities. pZR748 (SEQ ID NO: 63) includes coding sequences for a S. cerevisiae OXS, a S. cerevisiae OXC, and an O. formigenes OxlT. pZR753 (SEQ ID NO: 64) includes coding sequences for an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, and an O. formigenes OxIT.

pZR761 (SEQ ID NO: 65) includes coding sequences for a S. cerevisiae OXS and a S. cerevisiae OXC. pZR856 (SEQ ID NO: 66) includes a coding sequence for an O. formigenes OxIT.

pZR878 (SEQ ID NO: 67) includes coding sequences for an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, a S. cerevisiae OXC, an A. thaliana OXS, and an E. coli ACOCT.

[00131] Each copy of an oxalate catabolism-related gene was operably linked to a copy of either a phage derived promoter, P_BfP1E6 (SEQ ID NO: 68), or a weakened version thereof, P_BfP4E5 (SEQ ID NO: 69). Other promoters, including P_BfP2E5 (SEQ ID NO: 80) and others those matching a phage-derived consensus sequence (SEQ ID NO: 70), can also be used. To optimize the translation rate of the enzymes, enzymes were fused to either a leader peptide coupled to a high-strength ribosome binding site (RBS) (SEQ ID NO: 78), or a NanoLuc luciferase reporter enzyme coupled to a high-strength RBS (SEQ ID NO: 79). Other ribosome binding sites and translational fusions can also be used. The plasmids carry an NBU2 integrase gene, which catalyzes genomic integration of the plasmid at the 3’ end of a serine-tRNA gene in the Bacteroides genome.

[00132] Once constructed, the plasmids were transformed into Escherichia coli S17-1 donor cells bearing the RK2 conjugative plasmid. The RK2 conjugative machinery allows for conjugative transfer of plasmids bearing an RP4 transfer origin to a variety of species, including Bacteroides. These cells were mixed with Bacteroides recipient cells and plated onto

nonselective BHI agar plates for an overnight incubation at 37˚C. Afterwards, plates were scraped and the mixture of E. coli S17-1 and Bacteroides were transferred to selective media with gentamycin to suppress the E. coli and cultured under anaerobic conditions. Multiple selective markers (such as tetracycline, erythromycin, or chloramphenicol) can be used to deliver multiple constructs into a single Bacteroides strain.

Example 2– In Vitro Testing Of Oxalate Degradation In Liquid Culture

[00133] Engineered Bacteroides, constructed as described in Example 1, were assayed for oxalate degradation capacity in an in vitro assay. Bacteroides cells were diluted from an overnight culture 1:10 into BHIS liquid media with 10 or 30 mM added sodium oxalate. The cultures were incubated anaerobically at 37˚C overnight. After 48 hours, the cultures were centrifuged to separate out the cells, and the supernatant was taken for analysis. Samples were analyzed using a 595 nm oxalate oxidase kit (Sigma-Aldrich, Catalog # MAK315-1KT) and compared to a standard curve in order to calculate oxalate consumption rates. The resulting data from testing plasmids pZR748 (SEQ ID NO: 63), pZR753 (SEQ ID NO: 64), pZR753 + pZR761 (SEQ ID NOs: 64, 65), and pZR856 + pZR878 (SEQ ID NOs: 66, 67) in a background of Bacteroides vulgatus ATCC 8482 is shown in FIGURE 4. As depicted, oxalate consumption of each engineered strain was increased relative to wildtype, which showed no capacity for oxalate consumption.

Example 3– Engineering Of Privileged Nutrient Consumption Into Bacteroides

[00134] A polysaccharide utilization locus (PUL) is a mobile genetic element that confers the ability to consume new carbohydrates upon a bacterium. A porphyran consumption PUL was identified in the porphyran-consuming Bacteroides strain isolate NB001 (SEQ ID NO: 72) and a 60kb region of the PUL was cloned into a bacterial artificial chromosome (BAC) to make pWD035 (SEQ ID NO: 73). The content of pWD035 is shown in FIGURE 5.

[00135] Plasmid pWD035 was conjugated into Bacteroides vulgatus ATCC 8482 using E. coli S17-1 to generate strain NB075. This strain was tested for its ability to consume the marine polysaccharide porphyran. Cells were diluted 1:50 from an overnight culture into Salyer's minimal media containing 0.2% porphyran extract from Porphyra yezoensis nori. Over 14 hours of anaerobic incubation at 37˚C, the OD600, representing cell growth, was measured using a plate reader. Results, shown in FIGURE 6, demonstrated that only the cells that received the porphyran PUL gained the ability to consume porphyran for growth.

Example 4– Engineering Strains That Can Consume Both Oxalate And A Privileged Nutrient

[00136] FIGURE 7 shows plasmids (SEQ ID NO: 75-77) which can be used individually or in combination to generate Bacteroides with high-efficiency oxalate degradation capabilities. pZR0879 (SEQ ID NO: 75) includes coding sequences for an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, a S. cerevisiae OXC, an E. coli ACOCT, and an O. formigenes OxIT. pZR0901 (SEQ ID NO: 76) includes coding sequences for an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, a S. cerevisiae OXC, an A. thaliana OXS, an E. coli ACOCT, and an O. formigenes OxIT. pZR1871 (SEQ ID NO: 77) includes coding sequences for an E. coli FCOCT, an O. formigenes OXC, a S. cerevisiae OXS, a S. cerevisiae OXC, an A. thaliana OXS, an E. coli ACOCT, and an O. formigenes OxIT.

[00137] Strains that are capable of simultaneously consuming porphyran and oxalate were generated by conjugation and selective plating of plasmids pZR0879, pZR0901, and pZR1871, into strain NB075 (described in Example 3). An empty vector (pZR1622, SEQ ID 74) was also included in order to construct a non-oxalate consuming control strain. For two of the

conjugations (pZR879 and pZR1871), in order to find strains with increased oxalate

consumption rates, -3,000 colonies were isolated from an individual selective plate. These clonal isolates were then subjected to a modified version of the oxalate consumption assay described in Example 1 , which was run in high-throughput on a Labcyte Echo 525 acoustic liquid handling robot. Approximately 0.001% of clonal isolates proved to be outliers that demonstrated significantly faster oxalate consumption rates than the majority of isolates. Whole genome sequencing on an Illumina iSeq 100 was used to confirm that these strains harbored two copies of the plasmid of interest in their genome, presumably leading to increased expression of the oxalate pathway genes. Details of the generated strains, including the plasmid copy number, are depicted in TABLE 1.

[00138] The four oxalate-consuming strains (sWW152, NB 120, sWW554, and sWW626) were tested in an in vitro oxalate consumption assay to compare their respective oxalate consumption rates. Each strain was grown to saturation anaerobically in BHIS media at 37°C. The cultures were then pelleted and resuspended in one-tenth of the starting volume with fresh BHIS that had been supplemented with 4mM oxalate. Dilution plating of the 10-fold concentrated cultures indicated they contained ~1x10 ¹⁰ cfu /ml, which is the approximate abundance that these strains reach in the cecum when allowed to colonize the gut. The concentrated cultures were transferred back into an anaerobic chamber and allowed to incubate at 37˚C. At regular intervals, culture aliquots were removed from the anaerobic chamber, transferred onto ice, pelleted, and the supernatant was frozen. The supernatant aliquots were then measured to determine the concentration of oxalate remaining. Results are depicted in FIGURE 8. As expected, each strain reduced oxalate concentration in the supernatant, with sWW626, consuming 75% of the oxalate within 15 minutes.

Example 5– Ex Vivo Testing Of Oxalate Consumption Rates In Rat Cecal Contents

[00139] Candidate oxalate/porphyran-consuming strains described in Example 4 were next subjected to an ex-vivo oxalate consumption assay designed to simulate in vivo conditions as closely as possible. First, the cecums of multiple Sprague-Dawley rats fed a low oxalate diet were harvested, and the contents were extruded and diluted 3-fold into distilled water to aid in pipetting. Oxalate was added to a final concentration of 4mM. Oxalate-consuming strains were then added to a final concentration of 1x10 ¹⁰ cfu/ml to match their expected in vivo abundance in the cecum. Oxalate consumption over time was monitored as described above. Results are depicted in FIGURE 9. Again, each strain consumed oxalate in the cecal contents, although the rate of oxalate consumption in cecal contents was ~10-fold slower than it had been in BHIS media.

Example 6– In Vivo Efficacy In A Rat Model Of Secondary Hyperoxaluria

[00140] To demonstrate that oxalate-consuming Bacteroides strains can be used to treat hyperoxaluria, candidate strains were subjected to in vivo testing in a rat model of secondary hyperoxaluria. Hyperoxaluria was induced via a low calcium diet that causes overabsorption of dietary oxalate. FIGURE 10 and FIGURE 11 depict the results of in vivo experiments designed to test the efficacy of candidate therapeutic strains sWW152 and sWW554, respectively. Male Sprague-Dawley rats weighing approximately two hundred grams were housed individually in metabolic cages (Tecniplast, 3700M022) and fed a low calcium (<0.01%), low oxalate base diet (Envigo, TD.160869). Twenty-four-hour urine was collected daily and analyzed for total oxalate throughout each experiment. Starting on day three and continuing for the remainder of the experiment, either 52 µmol oxalate per day (FIGURE 10) or 30 µmol oxalate per day (FIGURE 11) in the form of fresh spinach was added to the base diet, resulting in hyperoxaluria. Starting on either day two (FIGURE 10) or day seven (FIGURE 11) and continuing for the remainder of the experiment, 780 mg porphyran/day was also added to the base diet. On day seven, either a control strain unable to degrade oxalate (NB075 in FIGURE 10 or NB124 in FIGURE 11) or the therapeutic, oxalate degrading strain (sWW152 in FIGURE 10 or sWW554 in FIGURE 11) was administered by adding 10 ⁹ cfu to the drinking water. Addition of sWW152 resulted in a 32% reduction in urine oxalate compared to the control strain (FIGURE 10, p=0.005), while the addition of the improved strain sWW554 resulted in a 46% reduction in urine oxalate compared to the control strain (FIGURE 11, p=0.0003). Both control and therapeutic strains colonized the rat gut at high abundance in the presence of porphyran, making up approximately 3*10 ⁹ cfu/mL of feces within a few days (FIGURE 12).These results demonstrate the ability of engineered oxalate degrading Bacteroides to lower urinary oxalate in a rodent model of secondary hyperoxaluria. Furthermore, given that strain sWW554 had a larger therapeutic impact than sWW152, increasing the strain’s oxalate consumption rate appeared to translate to improved in vivo efficacy.

Example 7– In Vivo Efficacy In A Rat Model Of Secondary Hyperoxaluria

[00141] To demonstrate that oxalate-consuming Bacteroides strains can be used to treat hyperoxaluria, candidate strains were subejcted to in vivo testing in a rat model of secondary hyperoxaluria.

[00142] sWW626 (as described in Example 4) was modified to contain an erythromycin resistance cassette to make strain sWW627. FIGURE 13A and FIGURE 13B depict the results of in vivo experiments designed to test the efficacy of candidate therapeutic strain sWW627.

[00143] Male Sprague-Dawley rats weighing approximately six hundred grams were housed individually in metabolic cages (Tecniplast, 3701M081) and fed a high fat (40%) base diet containing 86 µmol daily oxalate per rat. Twenty-four-hour urine was collected daily and analyzed for total oxalate throughout each experiment. Baseline urine oxalate was measured on days 1-2. Starting on day three and continuing for the remainder of the experiment, spinach was added to the base diet, resulting in hyperoxaluria. On day 7, rats were inoculated with no strain, a control strain able to grow on porphyran but lacking the oxalate consumption genes (NB124), or a therapeutic strain able to grow on porphyran and consume oxalate (sWW627). Strains were administered by adding 10 ⁹ cfu to the drinking water. Starting on day 12, porphyran was added to the drinking water (and increased throughout the course of the experiment as shown in

FIGURE 13A and FIGURE 13B.)

[00144] Strain abundance, measured by enumeration of colony forming units (CFU) per gram feces, is shown in FIGURE 13A. As depicted, an increase in strain abundance corresponded with higher porphyran concentrations in the diet. Urine oxalate is shown in FIGURE 13B, As depicted, administration of strain sWW627 reduces urine oxalate relative to no strain or the control strain. The reduction in urine oxalate by sWW627 increased as porphyran concentrations in the diet increased.

Example 8– In Vivo Efficacy In A Rat Model Of Secondary Hyperoxaluria

[00145] To demonstrate that oxalate-consuming Bacteroides strains can be used to treat hyperoxaluria, candidate strains were subjected to in vivo testing in a rat model of secondary hyperoxaluria.

[00146] Hyperoxaluria was induced in rats via Route-en-Y Gastric Bypass (RYGB) surgery. Rats were fed a diet that included porphyran, calcium and spinach. Urine for each animal was collected and the volume and oxalate concentration was measured each day. Oxalate concentration was measured via the EnzyChrom Oxalate Assay Kit (BioAssay Systems, Hayward, CA). Rats were administered a therapeutic strain able to grow on porphyran and consume oxalate (sWW627, described in Example 7), or a control strain.

[00147] Results are depicted in FIGURE 14. Rats that received RYGB surgery and were gavaged with a control strain showed a higher level of urine oxalate than rats that underwent a sham surgery. Rats that received RYGB surgery and were administered a therapeutic strain (sWW627) showed reduced urine oxalate relative to rats administered the control strain, and reversed the impact of RYGB surgery. Example 8– Engineering of Ribosome Binding Sites (RBSs)

[00148] Ribosome binding sites (RBSs) were screened from a synthetic library to produce a set of RBS sequences that can be used to tune expression of oxalate degradation genes. For each oxalate consumption gene of interest, over 1000 RBS sequences were screened from a library where the degenerate sequence NNNNNNNNWWWAAAWWTWANAAA was located immediately upstream of the translation start site of each gene. Each gene was also

translationally fused at the C-terminus to a luciferase protein. Upstream of each RBS, transcription was driven by the P_BfP1E6 promoter (SEQ ID NO: 68). Plasmids containing the expression cassette were genomically integrated into Bacteroides vulgatus, and individual clones of unique RBSs were grown to saturation in BHIS media. Luminescence of each saturated culture was measured with the Nano-Glo Luciferase Assay System (Promega Corporation, Madison, WI).

[00149] FIGURE 15A depicts the luminescence values for each clone of each indicated gene. Selected clones were isolated and sequenced to determine each RBS sequence of interest. SEQ ID NOs: 96-103 depict an A. thaliana OXS coding sequence with eight RBSs of interest. The RBSs in SEQ ID NOs: 96-103 are referred to as RBS1-8, respectively. SEQ ID NOs: 104-111 depict a S. cerevisiae OXS coding sequence with eight RBSs of interest. The RBSs in SEQ ID NOs: 104-111 are referred to as RBS1-8, respectively. SEQ ID NOs: 112-119 depict an O.

formigenes OXC coding sequence with eight RBSs of interest. The RBSs in SEQ ID NOs: 112- 119 are referred to as RBS1-8, respectively. SEQ ID NOs: 120-127 depict a S. cerevisiae OXC coding sequence with eight RBSs of interest. The RBSs in SEQ ID NOs: 120-127 are referred to as RBS1-8, respectively. SEQ ID NOs: 128-135 depict an E. coli ACOCT coding sequence with eight RBSs of interest. The RBSs in SEQ ID NOs: 128-135 are referred to as RBS1-8, respectively. SEQ ID NOs: 136-143 depict an E. coli FCOCT coding sequence with eight RBSs of interest. The RBSs in SEQ ID NOs: 136-143 are referred to as RBS1-8, respectively. SEQ ID NOs: 144-151 depict an O. formigenes OxIT coding sequence with eight RBSs of interest. The RBSs in SEQ ID NOs: 144-151 are referred to as RBS1-8, respectively. SEQ ID NOs: 152-162 depict a codon optimzed S. cerevisiae OXC coding sequence with eleven RBSs of interest. The RBSs in SEQ ID NOs: 152-162 are referred to as RBS1-8, RBS1b, RBS2b, and RBS3b, respectively [00150] Plasmids were reconstructed with the above sequence and genomically incorporated into Bacteroides vulgatus. Luminescence of cultures was assayed as described above. Results are shown in FIGURE 15B.

[00151] Example 9– In Vitro Testing Of Oxalate Degradation In Liquid Culture

[00152] Engineered Bacteroides were assayed for oxalate degradation capacity in an in vitro assay.

[00153] Bacteroides cells were diluted from an overnight culture 1:10 into BHIS liquid media with 16 mM added oxalate. The cultures were incubated anaerobically at 37˚C. After 20 hours, the cultures were centrifuged to separate out the cells, and the supernatant was taken for analysis. Samples were analyzed using a 595 nm oxalate oxidase kit (Sigma-Aldrich, Catalog # MAK315- 1KT) and compared to a standard curve in order to calculate oxalate consumption rates.

[00154] Strains tested included NB136 (containing no introduced oxalate consumption genes), sWW152 (as described in Example 4), sWW627 (as described in Example 7), and sWW1077. SWW1077 contains SEQ ID NO: 82, which includes an engineered oxalate consumption pathway along with the engineered RBSs identified in Example 8 (including RBS2-E. coli FCOCT (SEQ ID NO: 137), RBS2-O. formigenes OXC (SEQ ID NO: 113), RBS2-O.

formigenes OxIT (SEQ ID NO: 145), RBS1-E. coli ACOCT (SEQ ID NO: 128), and RBS1-S. cerevisiae OXS (SEQ ID NO: 104)). Results are shown in FIGURE 16. As depicted, oxalate consumption of each engineered strain was increased relative to the control strain, and the greatest oxalate consumption was seen for sWW1077

INCORPORATION BY REFERENCE

[00155] The entire disclosure of each of the patent and scientific documents referred to herein is incorporated by reference for all purposes.

EQUIVALENTS

[00156] The disclosure may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The foregoing embodiments are therefore to be considered in all respects illustrative rather than limiting on the disclosure described herein Scope of the disclosure is thus indicated by the appended claims rather than by the foregoing description, and all changes that come within the meaning and range of equivalency of the claims are intended to be embraced therein.

SEQUENCE LISTING

[00157] SEQ ID NO: 1 (Acetyl-CoA:oxalate CoA-transferase (ACOCT) from Acetobacter aceti strain 1023; EC 2.8.3.19; UniProt Accession A9X6P9; Aa_CoAT3):

ATGACTGAAACCACGCCAGCAAAACCGAAGGGGCCCTTTGATGGGCTCCTCGTTATT GATCTGA CACATGTGCTGAATGGTCCGTTCGGCACAACAATTCTAACAGATCTGGGGGCTCGTACAA TCAA GATCGAGCCACCGGGGCATGGGGATGATACGCGTACCTATGGCCCATATGTTGGAGATCA ATCG CTTTACTTCTCTTTTGTAAACAGGGGAAAGGAAAGCATTGTCCTTAACCTCAAGGATGAG GGCG ATCGAGCGATTTTTCTGGAAATGGTGCGTAAGGCCGATGTGCTGGCGGAAAACTTCCGCC CCGG CGTGATGGACCGTTTGGGTTTCAATTATGAGGAACTGGCAAAGATCAATCCACGGTTGAT TTAT GCATCTTCATCAGGGTTCGGTCAGACAGGCCCGCTCGCACATTATCCTGCCTACGATACT ATTG TGCAGGCCATGAGCGGCATCATGATGGCCACGGGCTTTCCCGATGGTCCGCCAACGCGGG TAGG GGGCACATCGCTTTCTGATCTGTGCGGTGGGGTTTTCATGTTCTGCGGCATTGCCAGTGC GCTT TATGCGCGTGAGCGCACAGGGAAAGGGGCACACATTGATGTTTCAATGTTTGATGGTACC TTGG CATTTTTGCAGCATGCTCTGATGTGCTGGTCTGCTACAGGCAAAGCCCCTGCGCGTATTG GCAA TCGCCATCCTTATATGGCGCCTTTTGATGTGTTTCAGGCGCAGGACAAGCCTTTTGTCAT CTGT TGTGGGAATGACCATCTTTTTAAGGCGCTTTGCGATGTGATTGGTGCGCCTGAACTGGCG ACAG ACCCGCGTTTTGTCGAAAATCATGATAGAATGGCCAATAATGATGCGCTGAAAGCTGCAT TGGA AAAAGCACTTTCCAAACAGCCAGCGGCGCATTGGCTGGATGTTATTCACAAAGCCGGTGT GCCT GTTGGGCCGTTGCTGGACGTGGCAGAGGCGGCAAATCTGCCACAAACAGCCGCGCGGAAT ATGC TGATTAAATCTGGCGGGGTGATGATGCCCGGTAACCCGGTGAAAATCAGTGGGTATGATG ACCC ACATGAACGGCCCGGCGCCCCTAAGCTGGATGAGCAGGGCGCGGCGTTGCGTAAGGAATT TGCC GCACCAGAGGCAAAATGA [00158] SEQ ID NO: 2 (Acetyl-CoA:oxalate CoA-transferase (ACOCT) from Escherichia coli MG1655; EC 2.8.3.19; UniProt Accession P76518; Ec_yfdE):

ATGACAAATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTATCGATATGACA CATGTCC TTAATGGACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAGGGTAATTAAAGTTG AGCC GCCGGGTCATGGTGATGATACCCGCACATTTGGTCCCTATGTGGATGGACAGTCACTCTA TTAC AGTTTTATTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGAATGATCACGATAAA AGTA TATTTATAAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTTTCGCCCAGGTACAA TGGA AAAACTGGGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGCCTCATATATGCTTC ATCG TCAGGTTTCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACGATACCATCATTCAG GCAA TGAGCGGGATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGTGCGCGTTGGTACAT CTCT TGCGGATCTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGTGCACTTTATGGCCG CGAA AAGAGCCAGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCACGCTGAGTTTTCTG GAGC ATGGTCTGATGGCATATATCGCAACTGGGAAGTCACCACAACGTCTGGGAAATCGCCATC CCTA CATGGCACCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACGATTTGTTGTGGTAA TGAC AAGCTTTTTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGGTTAATGATCCCCGA TTTA GCAGCAATATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATATATTGAGCGGACGT TAAA AACGCAGGCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGTGTACCCGTCGCGCC GTTA TTAAGTGTGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAAATATGTTGATTGAA GCCG GGGGAATAATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGCGGACCCGCATGTTA TGCC GGGAGCGGCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAGTTCTCATCATAA [00159] SEQ ID NO: 3 (Formate dehydrogenase from Saccharomyces cerevisiae S288C; EC 1.2.1.2; UniProt Accession Q08911; Sc_FDH1):

ATGTCGAAGGGAAAGGTTTTGCTGGTTCTTTATGAAGGTGGTAAGCATGCTGAAGAG CAGGAAA AGTTATTGGGGTGTATTGAAAATGAACTTGGTATCAGAAATTTCATTGAAGAACAGGGAT ACGA GTTGGTTACTACCATTGACAAGGACCCTGAGCCAACCTCAACGGTAGACAGGGAGTTGAA AGAC GCTGAAATTGTCATTACTACGCCCTTTTTCCCCGCCTACATCTCGAGAAACAGGATTGCA GAAG CTCCTAACCTGAAGCTCTGTGTAACCGCTGGCGTCGGTTCAGACCATGTCGATTTAGAAG CTGC AAATGAACGGAAAATCACGGTCACCGAAGTTACTGGTTCTAACGTCGTTTCTGTCGCAGA GCAC GTTATGGCCACAATTTTGGTTTTGATAAGAAACTATAATGGTGGTCATCAACAAGCAATT AATG GTGAGTGGGATATTGCCGGCGTGGCTAAAAATGAGTATGATCTGGAAGACAAAATAATTT CAAC GGTAGGTGCCGGTAGAATTGGATATAGGGTTCTGGAAAGATTGGTCGCATTTAATCCGAA GAAG TTACTGTACTACGACTACCAGGAACTACCTGCGGAAGCAATCAATAGATTGAACGAGGCC AGCA AGCTTTTCAATGGCAGAGGTGATATTGTTCAGAGAGTAGAGAAATTGGAGGATATGGTTG CTCA GTCAGATGTTGTTACCATCAACTGTCCATTGCACAAGGACTCAAGGGGTTTATTCAATAA AAAG CTTATTTCCCACATGAAAGATGGTGCATACTTGGTGAATACCGCTAGAGGTGCTATTTGT GTCG CAGAAGATGTTGCCGAGGCAGTCAAGTCTGGTAAATTGGCTGGCTATGGTGGTGATGTCT GGGA TAAGCAACCAGCACCAAAAGACCATCCCTGGAGGACTATGGACAATAAGGACCACGTGGG AAAC GCAATGACTGTTCATATCAGTGGCACATCTCTGGATGCTCAAAAGAGGTACGCTCAGGGA GTAA AGAACATCCTAAATAGTTACTTTTCCAAAAAGTTTGATTACCGTCCACAGGATATTATTG TGCA GAATGGTTCTTATGCCACCAGAGCTTATGGACAGAAGAAATAA [00160] SEQ ID NO: 4 (Formyl-CoA:oxalate CoA-transferase (FCOCT) from

Bifidobacterium animalis subsp. lactis DSM 10140; EC 2.8.3.16; UniProt Accession B9X295; Ba_frc):

ATGGCTGACAAAAGCACTGCCCCACTGGCAGGCATCAAGGTAATCGACTGGACGCAG GTTCAGT CTGGCCCTTCGTGCACCCAGATTCTCGCATGGCTGGGCGCCGAGGTCATCAAGCTCGAGA AGGT GCATGGCGGCGACCCGACCCGTAACGAGATGAACGACGTCGACGGCTCGTACTCGCTGTA CTTC CTGCAGCTCAACGCCAACAAGAAGTCGATCACGCTCGACATGAAGGACCCGGAAGGCAAG AAGA TCCTCACCGACCTGCTCAAGGACGCAGACGTGTTCGTAGAGAACATCGGCCCAGGCGACG TGGA AAAGCTCGGCTTCGGTTGGGACGAGGTCCACAAGATCAACCCGAAGCTCATCATGGCCTC GCTC AAGGGATTCAACCAGGGCAGCCGCTTCGAACATGTCAAGGCCTTCGAGCCTGTCGCCCAG TGCG CAGGCGGCGCTGCTTCGACCACCGGCTGGTGGGAAGGCGACAAGAACATCCCGACGCAGT CCGG CGCTGCCCTTGGTGATTCGAACACCGGTATGCACCTGACGATTGCAATCCTCACCGCACT GCTG CAGCGCGAGCGCACCGGCGAAGGCGTGTTCGTGTACCAGTCCATGCAGAATGCAGTGCTC AACC TATGCCGCATCAAGCTGCGTGATCAGCTCATTCTCGATCACCTACACCAGCTTTCCTACT ACGA GTGCTCGGCTGGTGCTATCGCGCCAAGGGCTGGGAAACCGATCCGAACGCCTATGTGTAC ATTG TGATTCAGCAGTCGCAGAAGGGATTCGAGAACTTCTGCAACGCCATGGGCTTCCAGGATT GGCT CACCGATCCGAAGTTCAGCACGCCGAACGCTCGCGATGAGCACAAGCAGGAAGTGTACAA GCGC GTCGAGGAATACACGATGCAGTACGACAAGTACACGCTCACCAAGGAACTCGGCGCCAAG GGCG TTCCGGTGGGCCCGGTGCTCGATTGGAACGAACTCGAAAACGATCCGGATCTCAACGAGG ATGG CACGCTGATCACGATCGATCAGGGCGACGCCCGCGGCAAGTTCAAGACGATCGGCCTGCC GTTC ACGATGAGCAACTATGCGCCGGATTACCAGCGCGCGCCGAAGCTCGGCGAGAACAACGAG GAGA TTCTCAAGTCCCTCGGCTACACCGACGAGCAGATCGCCGATCTGGCGACCAAGGGCGTCA TCGG CTCGAACGATGGCGTCAAGGCAGACCTCACCGCCGCTCCGGCACAGGCCTGA [00161] SEQ ID NO: 5 (Formyl-CoA:oxalate CoA-transferase (FCOCT) from Cupriavidus oxalaticus ATCC 11883; EC 2.8.3.16; Co_frc1):

ATGCCTGCACAACACACCCATGCCACGCCCGCCGGCCCGCTCGACGGCATCCGCGTG CTCGACC TGACCGCGGTCGTGCTCGGCCCGCTGGCCACGCAGGTGCTGGCCGATTTTGGCGCCGACG TGAT CAAGATCGAGGGGCCGGAAGGCGACCTGATGCGCGCCAACGGCGTGTCGCAGCACGCCGG CATG AGCTCGATCTACCTGGCGCTGAACCGCAACAAGCGCTCGGTCGTGCTCGACCTGAAAATC CCCG AGGGCGCCGAAGCGCTGCGCGCGCTGATCGCCGGCGCCGACGTGCTGGTGCACAACATGC GCGT GGCGGCGATCGAGCGGCTTGGTTTTGGCTACGAGGCCGTCGCACGCATCAACCCGCGCAT CGTC TACTGCGTCGCCACCGGCTTCGGCCAGGACGGCCCGCACCGCGACAAGCCCGCCTTCGAC GACA TCATCCAGGCCGGCTGCGGACTGGTGGCGCTGGGCGCCGGCAACGGCGAGCGGCCGGAAT ACGT GCCCAGCCTGATCGCCGACAAGACCACCGGGCTGGCGCTGGCCAATGCCGTGCTGGCCGC GCTG CTGCACCGCGAACGCCATGGCGTGGGCCAGTCGGTCGAAGTGCCGATGCTGGAAACCATG GCCG CCTTCGTGATGACCGAGCACCTGGGCGGGCTGACCTTCGAGCCCGCCCCCGCCGGCGCGG GCTA TGCGCGGCTACTGCAGGGCGGCCGCCGCCCGGCGCCGACGCGCGACGGCTGGATCTGCGC GCTG CCCTATACCGAGCGCCACTGGCATGCCTTCTTCCGCGCGGTGGGTCGCGATGACCTTGCC GACC GTTACGAAGTCGGCGACCGCGCACAGCGCAATGCCAATATCCGCGCGCTGTACGGCCATC TTGC CGAACTGACCCCGGAGCGCAGCACCGCAGAATGGATGGCGCTGTTCGAAGCGCTCGACAT CCCC GCCACGCCGATCTACGACCTCGATGCGCTGGTCGACCATCCGCACCTGCGCGCGGTGGGA CTGT TCCAGGCCACGCAGCACCCCACCGAAGGCCCGCTGCGCGAAGTGCGCCCGGCCGCGCGCT TCTC GGCCACGCCGCTGTCGTTGCGCCGGCATGCGCCGGCACTGGGCGAACACACCGCCGAAGT CTTG CAGGAAGCCGGCATCGCCCTGCCCGCCGCGCATGCCGGCACACCCGCCGGCGCTCAGGAA TAA

[00162] SEQ ID NO: 6 (Formyl-CoA:oxalate CoA-transferase (FCOCT) from Cupriavidus oxalaticus ATCC 11883; EC 2.8.3.16; Co_frc2):

ATGAACCTCCCGCTCAACGGCATCAAGATCATCGACTTCACGCACGTCCAGGCCGGC CCCGCGT GCACGCAGCTGCTGGCATGGTTCGGCGCAGACGTCATCAAGGTGGAGCGCCCCGGTTCCG GCGA CGTGACGCGCACGCAGCTGCGCGACATCCCGGATGTCGACGCGTTGTACTTCACCATGCT CAAC TCCAACAAGCGCAGCCTGACGCTGGACACCAAGAAGCCCGAAGGCAAGAAGATCCTGGAG CAGC TGATCCGCGAGTCGGACGTGCTGGTCGAGAACTTCGGCCCGGGTGCGCTGGACCGCATGG GCTT CTCGTGGGAACGCATCAACGAGCTGAACCCGAAGATGATCGTGGCCTCGGTCAAGGGCTT CAGC GACGGCCATCACTATGAAGACCTGAAGGTCTATGAAAACGTGGCGCAGTGCGCGGGCGGT GCGG CGTCGACCACGGGCTTCTGGGATGGTCCTCCCACCGTTTCCGCAGCGGCGCTCGGCGATT CGAA CACCGGCATGCACCTGGCCATCGGCATCCTGACCGCGCTGATCGGCCGCGACAAGACCGG CAAG GGCCAGAAGGTGGCCGTGTCGATGCAGGACGCCGTGCTCAACCTGTGCCGCGTCAAGCTG CGCG ACCAGCAGCGCCTGGACCGCCTGGGCTTCCTGGAAGAGTATCCGCAGTACCCGCATGGCA GCTT CAGCGACGTGGTGCCGCGCGGCGGCAACGCTGGCGGCGGCGGCCAGCCGGGCTGGGTGCT GAAG TGCAAGGGCTGGGAAACCGACCCCAACGCCTATATCTACTTCACCATCCAGGGCCATGCC TGGG AGCCGATCTGCAAGGCGCTCGGCAAGCCGGAATGGATCGACGATCCCAACTACGCCACCG CCAA GGCACGCCAGCCGCATATCTTCGATATCTTCAACACCATCGAGGAATGGCTCGCCGACAA GACC AAGTACGAGGCGGTGGACATCCTGCGCAAGCATGACATCCCGTGCTCGCCGGTGCTGTCG ATGA AGGAGATCGCGGCCGATCCGTCGCTGCGCGCCAGCGGCAGCATCACCGAGGTGCCACACA AGGA GCGCGGCACGTACCTGACGGTGGGCAGCCCGATCAAGTTCTCCGACCTCAAGCCGGAAAT CACG GGTTCGCCGCTGCTGGGCGAGCATAGCGAAGAAGTGCTGGCCGGCCTGGGGTACGGCACG GACG ACATCAAGCGCCTGCGCGAGTCCCAGGTGATCTGA [00163] SEQ ID NO: 7 (Formyl-CoA:oxalate CoA-transferase (FCOCT) from Escherichia coli MG1655; EC 2.8.3.16; UniProt Accession P69902; Ec_frc):

ATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGGC CCATCTT GTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGCGTTG GTGA CGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTTTACTTCACCATGCT TAAC AGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAATGGAA AAGC TGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCACATGG GCTT CACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAGGGTT TGAT GAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGGTGGC GCGG CATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGTGACA GCAA CACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAACGGG GCGT GGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAAATTA CGTG ACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAATGGTA CATT TGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGATCCT GAAA TGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTATTCAGGAGCAAAAC TGGG AAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCCGGCATACAGTACAG CCCA TGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCACTAT TGAT AAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTTAAGT ATGA AAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAACAAC CGTT GCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGGATAT TAAA GCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAGCGAC GATG AAATTGCTGCAATGAAGCAAAACCACGCCATCTGA [00164] SEQ ID NO: 8 (Formyl-CoA:oxalate CoA-transferase (FCOCT) from Oxalobacter formigenes DSM 4420; EC 2.8.3.16; UniProt Accession O06644; Of_frc):

ATGACTAAACCATTAGATGGAATTAATGTGCTTGACTTTACCCACGTCCAGGCAGGT CCTGCCT GTACACAGATGATGGGTTTCTTGGGCGCAAACGTCATCAAGATTGAAAGACGTGGTTCCG GAGA TATGACTCGTGGATGGCTGCAGGACAAACCAAATGTTGATTCCCTGTATTTCACGATGTT CAAC TGTAACAAACGTTCGATTGAACTGGACATGAAAACCCCGGAAGGCAAAGAGCTTCTGGAA CAGA TGATCAAGAAAGCCGACGTCATGGTCGAAAACTTCGGACCAGGCGCACTGGACCGTATGG GCTT TACTTGGGAATACATTCAGGAACTGAATCCACGCGTCATTCTGGCTTCCGTTAAAGGCTA TGCA GAAGGCCACGCCAACGAACACCTGAAAGTTTATGAAAACGTTGCACAGTGTTCCGGCGGT GCTG CAGCTACCACCGGTTTCTGGGATGGTCCTCCAACCGTTTCCGGCGCTGCTCTGGGTGACT CCAA CTCCGGTATGCACCTGATGATCGGTATTCTGGCCGCTCTGGAAATGCGTCACAAAACCGG CCGT GGTCAGAAAGTTGCCGTCGCTATGCAGGACGCTGTTCTGAATCTGGTTCGTATCAAACTG CGTG ACCAGCAACGTCTGGAAAGAACCGGCATTCTGGCTGAATACCCACAGGCTCAGCCTAACT TTGC CTTCGACAGAGATGGTAACCCACTGTCCTTCGACAACATCACTTCCGTTCCACGTGGTGG TAAC GCAGGTGGCGGCGGCCAGCCAGGCTGGATGCTGAAATGTAAAGGTTGGGAAACCGATGCG GACT CCTACGTTTACTTCACCATCGCTGCAAACATGTGGCCACAGATCTGCGACATGATCGACA AGCC AGAATGGAAAGACGACCCAGCCTACAACACATTCGAAGGTCGTGTTGACAAGCTGATGGA CATC TTCTCCTTCATCGAAACCAAGTTCGCTGACAAGGACAAATTCGAAGTTACCGAATGGGCT GCCC AGTACGGCATTCCTTGCGGTCCGGTCATGTCCATGAAAGAACTGGCTCACGATCCTTCCC TGCA GAAAGTTGGTACCGTCGTTGAAGTTGTCGACGAAATTCGTGGTAACCACCTGACCGTTGG CGCA CCGTTCAAATTCTCCGGATTCCAGCCGGAAATTACCCGTGCTCCGCTGTTGGGCGAACAT ACCG ACGAAGTTCTGAAAGAACTGGGTCTTGACGATGCCAAGATCAAGGAACTGCATGCAAAAC AGGT AGTTTAA [00165] SEQ ID NO: 9 (Oxalate decarboxylase (OXDC) from Bacteroides subtilis 168; EC 4.1.1.2; UniProt Accession O34714; Bs_oxdC):

ATGAAAAAACAAAATGACATTCCGCAGCCAATTAGAGGAGACAAAGGAGCAACGGTA AAAATCC CGCGCAATATTGAAAGAGATCGGCAAAACCCTGATATGCTCGTTCCGCCTGAAACCGATC ATGG CACCGTCAGCAATATGAAGTTTTCATTCTCTGATACTCATAACCGATTAGAAAAAGGCGG ATAT GCCCGGGAAGTGACAGTACGTGAATTGCCGATTTCAGAAAACCTTGCATCCGTAAATATG CGGC TGAAGCCAGGCGCGATTCGCGAGCTTCACTGGCATAAAGAAGCTGAATGGGCTTATATGA TTTA CGGAAGTGCAAGAGTCACAATTGTAGATGAAAAAGGGCGCAGCTTTATTGACGATGTAGG TGAA GGAGATCTTTGGTACTTCCCGTCAGGCCTGCCGCACTCCATCCAAGCGCTGGAGGAGGGA GCTG AGTTCCTGCTCGTGTTTGACGATGGATCATTCTCTGAAAACAGCACGTTCCAGCTGACAG ATTG GCTGGCCCACACTCCAAAAGAAGTCATTGCTGCGAACTTCGGCGTGACAAAAGAAGAGAT TTCC AATTTGCCTGGCAAAGAAAAATATATATTTGAAAACCAACTTCCTGGCAGTTTAAAAGAT GATA TTGTGGAAGGGCCGAATGGCGAAGTGCCTTATCCATTTACTTACCGCCTTCTTGAACAAG AGCC GATCGAATCTGAGGGAGGAAAAGTATACATTGCAGATTCGACAAACTTCAAAGTGTCTAA AACC ATCGCATCAGCGCTCGTAACAGTAGAACCCGGCGCCATGAGAGAACTGCACTGGCACCCG AATA CCCACGAATGGCAATACTACATCTCCGGTAAAGCTAGAATGACCGTTTTTGCATCTGACG GCCA TGCCAGAACGTTTAATTACCAAGCCGGTGATGTCGGATATGTACCATTTGCAATGGGTCA TTAC GTTGAAAACATCGGGGATGAACCGCTTGTCTTTTTAGAAATCTTCAAAGACGACCATTAT GCTG ATGTATCTTTAAACCAATGGCTTGCCATGCTTCCTGAAACATTTGTTCAAGCGCACCTTG ACTT GGGCAAAGACTTTACTGATGTGCTTTCAAAAGAAAAGCACCCAGTAGTGAAAAAGAAATG CAGT AAATAA [00166] SEQ ID NO: 10 (Oxalate oxidase (OXO) from Hordeum vulgare; EC 1.2.3.4; UniProt Accession P45850; Hv_OxOx):

ATGTCCGACCCAGACCCACTCCAGGACTTCTGCGTCGCGGACCTCGATGGCAAGGCG GTTTCGG TGAACGGGCATACGTGTAAGCCCATGTCGGAGGCCGGCGACGACTTCCTCTTCTCGTCCA AGCT GACCAAGGCCGGCAACACGTCCACCCCGAACGGCTCGGCCGTGACGGAGCTCGACGTGGC CGAG TGGCCCGGTACGAACACGCTGGGCGTGTCCATGAACCGTGTGGACTTCGCGCCGGGGGGC ACCA ACCCGCCGCACATCCACCCGCGTGCAACCGAGATCGGCATGGTGATGAAAGGTGAGCTCC TCGT TGGAATCCTCGGCAGCCTTGACTCCGGAAACAAGCTCTACTCCAGGGTGGTGCGTGCCGG AGAG ACTTTCGTCATCCCGCGCGGCCTCATGCACTTCCAGTTCAACGTTGGTAAGACGGAAGCC TACA TGGTTGTGTCCTTCAACAGCCAGAACCCTGGCATCGTCTTCGTGCCGCTCACACTCTTCG GCTC CGACCCTCCCATCCCCACGCCCGTGCTCACCAAGGCTCTCCGGGTGGAGGCCGGAGTCGT GGAA CTTCTCAAGTCCAAGTTCGCCGGTGGGTCTTAA [00167] SEQ ID NO: 11 (Oxalate oxidoreductase (OOR) alpha subunit from Moorella thermoacetica ATCC 39073; EC 1.2.7.10; UniProt Accession Q2RI41; Mt_OORA!):

ATGGGTAAAGTAAGGAATATCTCTGGATGTGTGGCGGTAGCACATGGTGTGCGGTTA GCCGATG TCGACGTTATCTGTTCCTATCCCATCCGGCCTTATACCGGTATCATGTCCGAGCTGGCAC GGAT GGTTGCCGACGGCGAGTTGGATGCCGAATTTGTCCATGGCGAAGGTGAACACGCCCAGTT GAGT GTCGTTTACGGCGCTTCGGCTGCCGGAGCACGGGTATTCACCGGTAGTTCCGGTGTCGGC GTAA CCTATGCCATGGAAGTCTATTCACCTATCTCTGGTGAACGTTTACCGGTACAGATGGCCA TTGC CGACCGGACCCTGGACCCGCCCGGTGACTTTGGTGAGGAACATACCGATGCCGAGTGTTG CCGG GACCAGGGCTGGATCCAGGGTTGGGCCTCCACTCCCCAGGAAGCCCTGGATAACACCTTG ATTT ACTACCGGGTAGGTGAAGACCAGCGGGTCTTGTTGCCCCAGTATGCCTGCCTGGACGGGT ACTT CGTCAGCCATATCCTAGGCCCGGTGGATATTCCCGACGAGGCCCAGGTGAAAGAGTTCCT GCCG CCTTACAAGAATCACCATGTCCTCGATCCCAGGAAGCCCCAGATTATCGGCCCTCAAATT GAGC CGGCCATGGGACCTCCCCTCCAATACCAGCGTTACCAGGCCGTTAAAGGCGTGCACAAGG TTCT AGAAGAGGCCTGTGACGAATTCGCCCGGATTTTCGGCCGCAAGTACGATCCCTACCTTGA TGAA TACCTGACTGACGATGCCGAGGTTATAATCTTCGGCCAGGGCGCCCACATGGAGACTGCT AAAG CGGTAGCCCGGCGCCTGCGCAACCTTGGTGAAAAGGTAGGAGTAGCGCGGCTACGTACCT TCCG GCCCTTCCCGACGGAACAAATTAAAGAGCGACTTTCTAAATTCAAGGCTATTGGTGTCCT CGAT GTTTCGGCCAACTTCGGCATTTCCTGCAGCGGCGGCGTCCTCCTGTCCGAACTGCGGGCC GCCC TCTATGACTACGGCGACAAAGTAAAGACCGTAGGCTTTGTAGCCGGCCTAGGCGGCGAAG TCGT CACCCACGATGAGTTCTACCGCATGTTCCAGAAACTAAAGGAGATCGCCAAGACAGGTAA AGTC GAGCAGACCTCTTATTGGATCCCCTTTGAATTATAA [00168] SEQ ID NO: 12 (Oxalate oxidoreductase (OOR) beta subunit from Moorella thermoacetica ATCC 39073; EC 1.2.7.10; UniProt Accession Q2RI42; Mt_OORB):

ATGCTGGATCGGATTGCATCTATTAAAAAGGCACCTGATGAGGAATACTATGTTCCC GGGCATC GTACCTGTGCCGGCTGCGGCCCGGCCCTGACCTATCGCCTGGTGGCCAAAGCCGCCGGTC CCAA CACCATCTTCATTGGTCCCACCGGCTGCATGTACGTGGCCAATACCAGCTACGGCTGCGG TCCC TGGCGGGTACCCTGGATCCATGCCCAGATCACCAATGGCGGCGCCGTGGCCTCCGGTATT GAGG CCGCCTATAAGGCTATGATCCGCAAGAAGAAGACCGACGCCGAGTTCCCGAACATTATCG TTAT GGCCGGTGATGGCGGCGCCGTCGATATCGGCCTCCAGGCACTGTCGGCCATGCTCTATCG CGGT CATGACGTCCTCTTTATCTGCTACGATAACGAGTCCTATGCCAATACCGGTATTCAGACC TCCC CGACGACGCCCTACGGGGCTAATACGACTTTTACCCCGCCTGGTGAGGTGGTACCGGAGG GCAA GAAGCTCTTCCCGAAGGATAACCCCAAGGTTATCGCCCACGGTCACCCGGAACTGAAGTA TGTC GCCACGGCCTCCATCGGCTGGCCGGTAGACCTGATGAACAAGGTCCGTAAGGGCTTAAAC CAGG AAGGTCCGGCCTATATCCACATCCACGCTCCTTGCCCCAAGGGCTGGCAGTTCCCGGCCG ACAA GACCATTGAAATGGCCAAATTGGCCGTCCAGACGGGCATGTTCCAGCTCTACGAATATGA GAAT GGTGAGTATAAACTGTCGGTTAAAGTCGATAAACGGAAACCGGTCAGCGAGTACATGAAA CTCC AGAAGCGGTTTGCTCACCTGAAGCCCGAGCATATCGCCAAGATGCAGGCCTTTGTCGACG CCCG CTGCGCTGAAGTAGGTATCACCGTGCCGGTAGTCGCTTCCAACGCTTAA [00169] SEQ ID NO: 13 (Oxalate oxidoreductase (OOR) delta subunit from Moorella thermoacetica ATCC 39073; EC 1.2.7.10; UniProt Accession Q2RI40; Mt_OORD):

ATGTCCACCAAAGATCTCTTTGCTGAACCCAATCTCAAGCAGATTACTGTGTGGGCC CGGGGCG TTGTCATGAACAAGGACGCCCGTGATATCGTGGTGGCCCTGACAGAAGCGGCTGCCAAAG AGGG TAAATATGTTCAGGCCTGGGAGAACTATGTTGACCTCCCCGACCGGATCTACGTCCCGGT AAGG GCCTATGCCCGCATCAGCAGCGATCCCATTGAAAGCAAATACATTTACGAGAATGAGACT CCCG ACATTGTTGTTTTAGTTGAAGAATCCCTGATCAAAGGAGTGCCCATACTGAAGGGCATCC GTCC GGGTAGTACCCTGGTTGTAAATACCAAACGTTCCATAGATACTATCCTTGAGTTCCTGGG TGAT ACCGGCAATCTGGCCCAAATCGTAACGGTGGATGCCAACAGTATGGCCGAGGCTGTCATG ACTT TGTCTGGCGCTGAAGGCGCTACTGACGCTACGGGTATTGGCGCCGGCATAGCGGCTCCCA TTGC GGGTGCTGTTGTCAAGGCTACAGGTATAGTTGATGTTGAAAACCTCGCCGCTGTGGTCAA GAAT CCCGCCGCCATGCGCCGGGGCTATGCGGAAGCCCAGGTGCGCCAGCTGCCGCCCCATGAA GCAG TTGAGGAAGCGGCCGTATCAGCGACTGAATTGTTGAGGCAAATGCCCTTTGCCGGGACGG TTCC CTCACCGGTAACGGAGAATGAGGGCATGGTAACCGGCAACTGGCGCATCCAAAGGCCCAT TATC GACCGGGAAGCCTGTACCGAATGTTATACCTGCTGGATCTACTGCCCCGATTCCTGCATC ACCA GGACCGAAGAAGGACCGGTATTTAATATGAAGTACTGCAAGGGCTGCGGCCTCTGTACGG CGGT CTGCCCCAGCGGCGCCCTGACTAATGTACCGGAACTTGACTTCAAAGATTAA [00170] SEQ ID NO: 14 (Oxalate--CoA ligase / Oxalyl-CoA synthetase (OXS) from Arabidopsis thaliana col-1; EC 6.2.1.8; UniProt Accession Q9SMT7; At_AAE3):

ATGGATAGCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCCCGAT CGCCGAG CTCTCTCCGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTAATCGAAC GCGC CGCTTCACGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTCTCACCTT CCCT AACACCGTCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCACGGCGGCG CCGT TGAACGCAGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGATTCAAAGC TATT GTTAACCTCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGAAAATCTC TCAC GTCACCGCTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGATTCAGAT TCCG TCGTTGACTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTCCTCCACA CTTC TGGCACTACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTTCATCCGT CAAG AACATTAAAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCTCCCTCTG TTCC ATGTTCATGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCTGTAACTC TTCC AGCTGCTGGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATAACGCTAC ATGG TATACTGCTGTGCCGACCATTCATCAGATCATATTGGACCGCCACGCGAGCCACCCTGAA ACGG AATATCCTAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTGATATTGT CCAG GCTTGAGGAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGGCAACACA TTTG ATGAGCTCAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGGGAAACCG GTAG GTCAAGAAATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAACAAAGGAG AGGT TTGTATAAGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCAACAAGGC AGGT TTCGAGTTTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGATACCGATGGGTATTTG CATC TGGTGGGTCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCAATTGAAG TGGA TGCAGTACTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTCCTGATGA GAAA TATGGGGAAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAACCGAAGAG GACA TTAAAGCGTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTGTTCATCA CTGA TAACCTCCCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAACATTTCCT TGAG AAGCCCTGA

[00171] SEQ ID NO: 15 (Oxalate--CoA ligase / Oxalyl-CoA synthetase (OXS) from Methylobacterium extorquens AM1 / DSM 1338; EC 6.2.1.8; UniProt Accession C5APP0; Me_oxs):

ATGACTATGTTATTACCTGAACCATCAGCTTTGTTACCAACAGATTCAAAGGAAGCC TCAGTCC CAGCAACAACATTGCATGAGTTGATACAAGCTGGTGCAGACGCTGCCCCTGCCTTATCTT CTCC AGGAGGAGTACCATTAACCTTTCAAGCATTAAGAGCCTTAACCGAGAGAACCGTCGCCGA CTTG AACGCAAGGGGTATTGGTAGAGGTGATAGAGTTGCCATTGTTTTGCCAAATGGACCAGAA ATGG CTGCAGCTTTCATTGCAGTAGCAGCCGGTACAACTTCAGCACCTTTAAATCCTTCTTACA AGGC GGACGAATTTGAGTTCTATATGTCAGATTTAGGTGCAAAATTATTATTAGTCGCAGAGGG TTCT GAGACTCCTGCCGTTGCCGTGGCTGAGAAATTGGGTGTTTCAGTAGCTAGATTAAGACCA ACTC CAGATGAAGGAGCAGGTTCTTTTACTTTACATTTTGCCTCAGAGTCTACTGGTCCAACCG AAAA GTCAGGTCCTGCAGGTTCAGATGATATAGCTTTGGTATTGCACACATCAGGTACCACATC TAGG CCTAAGATTGTCCCATTGACTCAAGCAAATGTATGCGCATCTGCTAGAAACATTAGGACT GCAT TAGCCTTTGGCCCGGAAGATAGAGGATTAAACATAATGCCTTTGTTCCATATACACGGAT TAAT CGCTGGAATTTTAGCCCCATTATCTGTCGGTGGTCAAGTCTCTTGCACTCCAGGTTTCAA CGCA TTGAAATTCTTTGGATGGATGGATGAAGTCAATCCAACCTGGTACACCGGAGTACCAACA ATGC ATCAAGCCATTTTAGGAAGGGCAGCAAGAAATAAAGAAATTATCGCCAGGAACCCTTTAA GATT TATCAGATCTTCTTCATCATCTTTGCCACCACAAGTCATGAAAGAGTTGGAGGAAACCTT CGGT GCTCCTGTTATTGAAGCATACGGAATGACCGAAGCTGCACATCAAATGGCCTCAAACCCA TTAC CTCCTAAGCCTCACTATGCTGGTTCTGTAGGTTTGGCTGCAGGTCCTGAGATTGCTGTTG TCGA CTTAGACGGTGAACCTTTACCAGCTGGAGAGACAGGTGAAATAGTCATAAGAGGTGACAA CGTT ATGAAGGGTTACGAAAACAACGAGAAGGCAAATGCAGAAGCATTCACCAAGCAGGGTTGG TTCA GAACTGGTGACCAAGGTGTCTTGTCTCCAGAGGGATACTTATCTATCACTGGAAGGTTAA AGGA GATAATCAATAGGGGTGGTGAGAAAATCTCACCAAGAGAAGTAGATGAAATTTTGATGGA CCAT CCTGCAGTATCACAATGCGTTACATTTGCGGTTCCTCATGATAAATTGGGTGAAGATGTT GCTG CTGCCATCGTCTTAAGGGAGGGTGTTGAAGCCGTTGAAAAGGACATTCGTAGCTTCGCTT CAGA AAGATTAGCAGCATTTAAAGTACCTGCCAAAATCTTAATTTTGGATGAAATCCCAAAAGG TGCC ACAGGTAAGTTGCAAAGAATAGGTTTGGCACAGAAATTGGGATTGGTTTAA [00172] SEQ ID NO: 16 (Oxalate--CoA ligase / Oxalyl-CoA synthetase (OXS) from Saccharomyces cerevisiae S288C; EC 6.2.1.8; UniProt Accession P38137; Sc_YBR222C): ATGACAAGTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTAGCGTATCCGATAAT GTCG CCGTTATTGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCTATCCCACATGGTGG GTCA CTTCCAGACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCTGTTTTCAGACAAGA TACA CTAAAATTGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTTCAATTTTTATTTGA ATGA CCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTACAGAGTTCTGAAAT TCTA AAATCTGCCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCGATGCGACCAGGTTT AGGG TAGAGTATGATATATACTCTCCAGAGGACAACTACAAAAGGGTTATTTACCGGTCTTTGA ACAA CGCCAAATTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCCCGTTCCAGTGACGT TGCC CTGATTTTGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGCCTTTGTTACATTTG AACA TTGTGAGAAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCCCTTGGACAGATCTT ATGT CGTGATGCCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTTTCCACTTTTAGAAC TCAG GGTTCTGTTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGGACCAATTTGTTAAG TACA ACTGTAATTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCTGAACATGCCCAAAC CAAA CCCTTTCCCACACATTAGATTCATCAGATCGTGTTCTTCTGCTTTGGCTCCAGCAACGTT CCAT AAGCTGGAGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGATGACCGAAGCATCA CATC AAATGACCTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTACTGTGGGCCAGCCAC AAGG AGTCACCGTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCGGGCAAAGTCGGCGA AGTT TCCATCAGAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAAAAGCTAACAAGGAG AACT TCACCAAGAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTTCGACCCTGAGGGGT TTTT GGTCCTTACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAAAAGATTTCACCCAT TGAG CTCGACGGCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTGCATTTGGTGTTCCC GACG ATATGTACGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGGAGAAAAAATGACCT ACGA AGAACTGGTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATTCCAACCAAGGTGTA CTTT GTTGATAAGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAGTTATCGCAGAAACT TTTG CTAAGAGCAGCAGAAATAAGAGTAAGTTGTAA [00173] SEQ ID NO: 17 (Oxalate:formate antiporter (oxlT) from Bifidobacterium animalis subsp. lactis DSM 10140; UniProt Accession B9X293; Ba_OxlT):

ATGACAAAGATATTGATAGACGACATCATCCCCATCATCGTCATCATGGCGTTGGGC TATGTCT GTGGAAAACTCAGCTACTTCGACAACGATCAGCGTCAGGGCCTCAACAAGCTCGTGCTGA ACAT CGCCCTCCCTGCCGCACTGTTCATCTCGATCGTCAAGGCGACCCGTGAGATGCTCGCACA GGAT GCGGTGCTCACAATTCTCGGCTTCATCGGCATCATCGTGATGTTCATGTTGAGCTACTAC CTGT GCCGACTGATGTTCCACCATTCGATCCAGGAAGCGGCCGTATGCGCGTTGATCGCCGGCT CGCC GACCATCGGCTTCCTCGGCTTCGCCGTGCTCGACCCGATCTACGGCGACACCGTGAGCAC GAAC CTCGTCATCGCGATCATCTCGATCGTCGTCAACGCCGTCACGATTCCGATCGGCATGTAT CTGA TCAACCTCGGCCAGAGCAAGGATCGCGAGCGCCTGTCGAAGGCCGCCGTCACGAACTCGA AGGG CCAGGTCAGCATCGCCAATCCGAAGGACGATATCGCCGTCGATCCGAACAAGGATGCGAA GACC GACAAGACGGCAGAGGTGATGATCTCCAAGTCGTCGAACATGGGCAAGAAGAAGAACCAG AACC TCGAAGCGCTCATCAACGCACTCAAGCAGCCTGTGTGCTGGGCTCCGCTGCTCGCCATCG TGCT CGTGCTCATCGGCGTGCGCGTGCCGTCCGGTTTCGCTCCCACCTTCGACCTGATTGCCAA AGCG AACTCCGGTGTCGCCGTGCTGGCCGCCGGCCTCGCGCTCTCCACTGTGAAGTTCTCGCTG GGCT GGGAAACGATCTGGAACACGTTCTACCGCTTGATTCTCACCCCTGCGGCATTCCTCGGCG TCGG CCTGCTGCTGGGCATGGGCAGCAATGTGAACAAGCTCTCCATGCTCGTCATGGCTGTGGC CCTG CCGCCTGCATTCTCCGGCATCATCATCTCGAGCCGCTACAACATCTACGTCAAGGAAGGT GCGT CGACCACCGCGGTTTCCACGGTTGCGTTCGCCGTCACCTGCCTGCTGTGGATCTGGCTCG TGCC GCTGTGCTGCCACTGA [00174] SEQ ID NO: 18 (Oxalate:formate antiporter (oxlT) from Cupriavidus oxalaticus ATCC 11883; Co_OxlT1):

ATGAGTAACGCAACGGCAGGGGCCCTGAGCCCCAATCAGGGAGCTTCGGAATCCACG CGCTGGA TCCAGCTGCTCGTCGGCGTGGTCTGCATGATCGCCACGGCCAACATCCAGTACGCCTGGA CGCT GTTCGTGCCTGAGATCCAGGATACCTACGGCTGGTCACGCGCCAGCATCCAGATTGCCTT TACC GTGTTCGTGCTGGTGCAGACCTGGCTGGCGCCGATCGAGGGCTACTTCATCGACAAGTTC GGGC CGCGCATGATGGTGGCCTTCGGCGCGCTCTTTATCGGCACGGCGTGGGTCATCAACTCGC AGGC GACCACGCTGATGGGCTTCTACGTCGGCGCCGCCGTCGGCGGCCTGGGCGTGGGCTCCAT CTAC GCGACCTGCATCAACAACGCGCTGAAGTGGTTCCCGGACCGCCGCGGCCTCGCGGTCGGC CTGA CCGCCGGCGGCTATGGCGCGGGCTCGGCGGCGACCATCCTGCCGATCGCGGCGATGATCG AGTC GCAGGGTTTCCAGCACACCTTCCTGTTCTTCGGCCTGCTGCAGGGGTCGCTGGCCTTTGT CGCG GCGTGGTTCCTGCGCTCGCCCAAGACCGGCGAGGTGCGGGGGTCGAAGAAGCTGGCCCAG GCCA CGCGCGACTACACCCTCAAGGAAGCGCTGTGCACCAGGCTGTTCTGGCTGATGCTGGTGA TGTT CGTGCTGGTGGTCACGGGCGGCATGATGGCCGTGGCGCAGCTCGGTGTCATCGCCAAGGA CCTT GGCGTGAAGGAATTCCAGGTCGACCTGCACTTCTTCGTGATGGCTGCACTGCCGCTCGCC CTGA TGCTGGACCGCATCATGAACGGCATCTCGCGTCCGCTGTTCGGCTGGATCTCGGACAACA TCGG CCGTGAAAAGACCATGGTGATCGCCTTTACGCTGGAAGGGCTGGGCATCATCGCGCTGGG CTAC TTCGGCAGCAACCCGTACGCCTTCCTGATCCTGTCCGGCGTGGTGTTCCTGGCCTGGGGC GAAG TCTACTCGCTGTTCTCGGCACTGGCGGGCGATGCCTTCGGCACCAAGCACATCGGCAAGA TCTA CGGCGTGCTGTACACCGCCAAGGGCATCGGCGCACTGTTCGTGCCGATCGGCAACCTGCT GATG GAAGCCACCGGCACGTGGTCGACGGTGCTCTACACGGTGGCGGTGATGGACCTGACCGCG GCGT TCCTTGCCATCATGGTGCTGCGGCCGGTGCTTGCCTCGCACGTTGCGACATCGAGGCAGC GGTT TGCGCAGGAATCTGCCGCGGCCGGCGCGCAAGTGGCGGCTTGA [00175] SEQ ID NO: 19 (Oxalate:formate antiporter (oxlT) from Cupriavidus oxalaticus ATCC 11883; Co_OxlT2):

ATGGAATTGCAGCAGAGGGAGTCCACGTCGCGCTTTGCGTCGCCGTGGGTGCAATTG GTCTTTG GCGTGATCTGCATGGCGATGATCGCCAACATGCAGTACGGCTGGACGCTGTTCGTCAACC CGAT CGACGACAAATACCACTGGGGCCGCACCGCGATCCAGGTGGCATTCACCATCTTCGTCGT GACG GAAACCTGGCTGGTACCGATCGAGGGCTACCTCGTCGACAAGTACGGCCCGCGCCCGGTA GTGG TGGGCGGCGGGTTGCTGTGCGCCATCGCGTGGGCGCTGAACTCGGTGGCGTCCTCGCTGC CGAT GCTGTACTTCGCGGCCGCAATCGGCGGCGTGGGTGCCGGCGCGGTCTACGGCACCTGCGT GGGC AATGCGCTCAAGTGGTTCCCCAACCGGCGCGGGCTGGCGGCGGGCATTACCGCAGCAGGC TTTG GCGCTGGTTCCGCGATGACCGTGGTGCCGATCGCCAACATGATCAAGACCTCGGGCTATG AAGC CACCTTCCTGTGGTTCGGGCTGGGGCAGGGCCTGATCGTCTTCATCCTCGGCCTGGCCCT GTAT CCGCCGTCGGCCAGGATCCTGAGCGAGGTCAAGACCACGCTCAAGGCCGCCGCGACCTAC AACG CCACGCCGCGCCAGGTGCTGAAGTCGCCGATCTTCTGGATCATGTACGCCATGTTCGTGA TGAT GGCCGCCGGCGGGCTGATGGCCACCGCGCAGTTGGGCCCGATCGCCAAGGACTTCGGCCT GCAT GACTCGCCGGTGTCGATCCTCGGCCTGACGCTGCCCGCGCTGACCTTCGCGCTGACCATC GACC GCGTGCTCAACGGCCTGACCCGCCCGTTCTTCGGCTGGATCTCCGACCATATCGGCCGCG AGCG CACCATGTTCTTCGCCTTCGCGGTGGAGGCGGTCGGCATCCTGCTGCTGTCCAAGTACGG CCAC AACCCGGTGGCGTTCGTGGTGCTGACCGGCATCGTGTTCTTTGCCTGGGGTGAGATCTAC AGCC TGTTCCCGGCCACCTGCGGCGATACCTTCGGTCCCAAGTTCGCCGCCACCAACGCCGGCT TGCT GTACACCGCCAAGGGCACGGCTGCGTTGCTGGTGCCGTTCTCCAGCGTGATCACCGCCGC CACC GGCGACTGGCACGCGGTGTTCATGCTCGCCTCCGGCATGGCGGCGCTGTCGGCGGTGCTG GCGC TGTTCGTGCTCAAGCCGATGCGTGAAGCCCATGCCCGCAAGTATGTCCACGCCAATACCG CGGC GCCGATGGGCTATCGTGCCGTGCAGGAAGACCTGACCTGA [00176] SEQ ID NO: 20 (Oxalate:formate antiporter (oxlT) from Escherichia coli MG1655; UniProt Accession P37662; Ec_YhjX):

ATGACACCTTCAAATTATCAGCGTACCCGCTGGCTGACACTCATCGGTACTATCATT ACCCAGT TTGCGCTGGGGTCGGTTTATACCTGGAGCCTGTTTAATGGCGCGCTTTCCGCCAAGCTGG ATGC GCCGGTAAGCCAGGTCGCTTTCTCTTTCGGCTTGTTAAGTCTGGGGCTGGCAATTTCGTC TTCT GTTGCGGGCAAATTACAGGAACGTTTTGGCGTTAAACGCGTCACCATGGCTTCCGGCATT TTGC TGGGATTAGGCTTCTTCCTGACAGCGCATTCTGACAACCTGATGATGCTGTGGTTAAGCG CCGG TGTGCTGGTGGGACTGGCAGATGGCGCGGGTTATCTGCTGACGCTCTCTAACTGTGTGAA GTGG TTCCCGGAGCGTAAAGGTCTGATCTCCGCGTTCGCTATCGGTTCTTATGGTCTGGGTAGC CTGG GTTTCAAATTTATCGACACGCAGCTGCTGGAAACGGTCGGTCTGGAAAAAACCTTTGTGA TTTG GGGAGCGATTGCGCTGTTGATGATTGTTTTCGGCGCAACGTTAATGAAAGACGCACCAAA ACAG GAAGTGAAAACCAGCAATGGTGTGGTGGAGAAAGATTACACGCTGGCAGAGTCGATGCGT AAAC CGCAGTACTGGATGTTAGCGGTAATGTTCCTGACCGCCTGCATGAGCGGCCTGTACGTGA TTGG GGTAGCGAAAGATATCGCCCAAAGTCTGGCACACCTTGATGTGGTTTCCGCAGCCAATGC AGTC ACTGTTATTTCCATCGCCAACCTTTCAGGTCGTCTGGTGCTGGGTATTCTGTCTGACAAA ATCG CCCGTATCCGTGTTATTACCATTGGTCAGGTGATATCGCTGGTGGGTATGGCGGCCCTGC TGTT TGCACCATTGAATGCAGTGACGTTCTTTGCAGCGATTGCCTGCGTGGCATTTAACTTTGG CGGC ACTATTACCGTCTTTCCGTCACTGGTCAGTGAGTTCTTTGGCCTCAATAACCTGGCGAAA AACT ACGGTGTGATTTATCTCGGTTTCGGTATCGGTAGCATTTGTGGTTCGATTATCGCCTCAC TGTT TGGCGGCTTCTATGTGACCTTCTACGTGATTTTCGCCCTGCTGATTCTGTCATTGGCGCT TTCT ACGACGATTCGTCAGCCAGAGCAGAAAATGTTGCGTGAGGCGCATGGCTCCCTTTAA [00177] SEQ ID NO: 21 (Oxalate:formate antiporter (oxlT) from Oxalobacter formigenes DSM 4420; UniProt Accession Q51330; Of_oxlT):

ATGAATAATCCACAAACAGGACAATCAACAGGCCTCTTGGGCAATCGTTGGTTCTAC TTGGTAT TAGCAGTTTTGCTGATGTGTATGATCTCGGGTGTCCAATATTCCTGGACACTGTACGCTA ACCC GGTTAAAGACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACGGCTTTCACACTCTCTCA GGTC ATTCAAGCTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATAAATTCGGTCCAAGAATT CCAT TGATGTTCGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCATGGGTATGGTTGACAGTG TTCC TGCTCTGTATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGTATCGTTTACGGTATCGC GATG AACACGGCTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTTCCGGTTTCACCGCTGCC GGTT ACGGTCTGGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGTTCTGAAAGTTGAAGGTG TTGG CGCAGCATTCATGTACACCGGTTTGATCATGGGTATCCTGATTATCCTGATCGCTTTCGT TATC CGTTTCCCTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTACCGACAAGGATTTCAAT TCTG GCGAAATGCTGAGAACACCACAATTCTGGGTTCTGTGGACCGCATTCTTTTCCGTTAACT TTGG TGGTTTGCTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGG TGTG CTGACGATCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGT TTCG TTTCCGATAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTTCGGTATCAATGCTGTTG TTCT CGCACTTTTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTTATCGCCATGTTGGCAAT CGCA TTCTTCACATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCAACAGCGATATTTTCGGT ACGG CATACTCTGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGCAACTGCCTCGATCTTCG GTGG TGGTCTGGGTGCTGCAATTGCAACCAACTTCGGATGGAATACCGCTTTCCTGATTACTGC GATT ACTTCTTTCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAAGAATGGGCCGTCCAGTC AAGA AAATGGTCAAATTGTCTCCAGAAGAAAAAGCTGTACATTAG [00178] SEQ ID NO: 22 (Oxalyl-CoA decarboxylase (OXC) from Bifidobacterium animalis subsp. lactis DSM 10140; EC 4.1.1.8; UniProt Accession B9X297; Ba_oxc):

ATGGTTGATGTAAGTGTAACTGCTACAAGCTCAGACCAGAATCTCACGGATTCTCCC CACTACC TCGCCGAAACGCTCATCAAGAACGGTGTCAAGCATATGTACGGCGTCGTCGGAATCCCGG TCAC TGATTTCGCACGTATCGCACAGGGCATGGGCATCCGCTTCATCGGCATGCGCCATGAGGA GGAC GCGGTGAACGCTGCCGCTGCCGAAGGATTCCTCACCGGTCGCCCAGCTGTGGCGCTCACC GTTT CCGCGCCGGGCTTCCTCAATGGTCTGGCACCGCTGCTTGAAGCCACCACGAACGGCTTCC CGGT CATCATGATCGGCGGTTCGTCCACTCGCCATGTCGTCGACATGCACGAAGGCGAATACGA AGGC CTCGACCAAATGAACTATGCGAAGCAGTTCTGCAAGGAATCGTTCCGCATCGACAAGATC GAAG ACATTCCGCTTGCTGTGGCCCGCGCCATGCACATCGCATGCTCCGGCCGTCCGGGCGGTG TCTA CATCGATTTCCCGGACGACGCCGTCGCCCAGACGCTCGACAAGGATGTCGCCGAGTCGCA GCTG TGGGTCGCGAACCAGCCGGCTCCGGCAATGCCGCCGGCGCAGTCCTCTGTGGATGAAGCG CTCA AGCTGCTCTCCGAGGCCAAGAACCCTCTCATGCTTGTGGGCAAGGGTGCGGCGCTGGCCC AGGC CGAGGACGAACTGCGTGAATTCGTCGAGAAGACCGACATGCCATTCCAGCCGATGTCGAT GGCC AAGGGCGTCATTCCGGACGATGACCCACACTGCACGGCGAGCTGCCGCGGACTCGCGCTG CGCA CCGCCGACGTCGTGCTGCTCGTCGGCGCTCGTCTGAACTGGATGCTCAATTTCGGCGAGG GCAA GGAATGGAACCCGAACGTCAAGTTCATCCAGATCGATATCGACCCGAACGAGATCGAGAA CGCC CGTTCCATCGCATGCCCGGTGGTCGGCGACATCAAGTCCGCCATGCAGATGATCAATGCC GGAC TCGAGAAGACGCCAGTGAAGGCGTCCGCGCAGTGGCTCGACATGCTCAAGGCCGACGCCG AGAA GAACGATGCCAAGTTCGCCGCCCGCGTGAACTCGAACACCGTGCCGATGGGTCACTACGA CGCG CTCGGCGCCATCAAGAAGGTGTACGACCAGCACAAGGACATGATCCTGACCAACGAGGGC GCGA ACACGCTCGACGATTGCCGCAACATCATCGACATCTACCAGCCGCGCCATCGTCTAGACT GCGG CACGTGGGGCGTTATGGGCTGCGCGGTCGGCTATTCAATCGGCGCCGCAGTGGCCACCGG CAAG CCTGTCCTGTACGTCGGCGGTGATTCCGGCTTCGGCTTTGACGGCATGGAAGTCGAGGTC GCCT GCCGCTACAATCTGCCGATCACCTTCGTCGTGCTCAACAACGGCGGCATCTACCGCGGCG ATTT CGAGAATCTCGGCGACGACGGCGACCCGTCGCCGCTGACGCTGAGCTACGACGCCCACTA CGAG CGCATGATCGAGGCGTTCGGCGGCAACGGCTATTACGCGACCACCCCGGCGGAAGTCGAG CAGA TGGTCGGCGAGGCCGTCGCCTCCGGCAAGCCGAGCCTCGTGCACGTGCAGCTCGCCGATT ATGC GGGCAAGGAGTCCGGGCACATCTCCAACCTGAACCCGAAGCCCGTCGTCGGCCCGCTCGC CACT TCCGAAATGACCGCGAACCCCTACCTCAAGGGCGCCCATATGTGA

[00179] SEQ ID NO: 23 (Oxalyl-CoA decarboxylase (OXC) from Cupriavidus oxalaticus ATCC 11883; EC 4.1.1.8; Co_oxc):

ATGGCAGAAGTCGGAAACGAGCTGCAGCGTCACGCCGCGGAAGAGCATCAGGCACAA ACCGATG GTTTTCATCTGGTCATCGACGCGCTGAAGCTGAACGGCATCGAAAACATCTACGGCCTGC CCGG CATTCCGGTCACCGACCTGGCTCGGCTGGCGCAGGCAAACGGCATGCGCGTCATCAGCTT CCGC CACGAGCAGAACGCAGGCAACGCCGCAGCGATTGCCGGCTTTCTGACGCAAAAGCCAGGC GTTT GCCTGACCGTGTCTGCGCCAGGGTTCCTGAACGGGCTCACGGCGCTGGCGCATGCGACCA CCAA CTGCTTCCCGATGATCCTGATCAGCGGCTCGAGCGAGCGCGAGATCGTCGATCTGCAGCA GGGT GACTACGAAGAGATGGACCAGCTGGCCATCGCCCGTCCGCACGCCAAGGCTGCCTTCCGC GTGC TGCACGCCGAAGACATCGGCGTCGGGATCGCGCGTGCCATCCGTGCCGCCGTGTCGGGCC GCCC GGGCGGTGTGTACCTGGACCTGCCGGCCAAGCTGCTGGGCCAGTCGATGGAAGCCGAGAA GGGC CGCAAGTCGCTGATCAAGGTGGTGGATCCGGCCCCGCGCCAGCTGCCTGCTCCGGACTCG GTCG ACCGTGCCGTCGCGCTGCTGAAGAGCGCCAAGCGCCCGCTGATCCTGGTAGGCAAGGGTG CTGC GTACGCACGCGCCGAAGCGGATATCCGCACGCTGGTCGAGAAGACGGGCATTCCGTACCT GCCG ATGTCGATGGCCAAGGGCCTGTTGCCCGATACGCACCCGCAATCGGCCTCCGCCGCACGC TCGT ATGTGCTGGCCGAAGCCGACGTGGTGCTGCTGGTCGGCGCCCGCCTGAACTGGCTGCTGT CGCA CGGCAAGGGCAAGACCTGGGGCAAGCCGAAGCAATTCATCCAGATCGACATCGCGCCGAC CGAG ATGGACAGCAACGTCGCCATCGCCGCGCCGGTCGTGGGTGACATCGGTTCGTGCGTGTCG GCGA TCCTCGACAAGGTCGGCGACGACTTTGCCAGGCCGGGCGCCGACTGGCTGAACGCGGTGG CTGA CCGCAGGGACACCAACCTGGCGAAGATGGCCGAAACCCTGGCCAGGTCCAGGGACGCCTC GCCG ATGAACTTCCACGGTGCGCTCGGCGTGCTGAAGGATGTGGTCAAGGCCAACCCGAACATC TCGT TCGTCAACGAAGGCGCCAACACGCTGGACTACGCCCGTGCCGTGATCGACATGTACGAGC CGCG CAAGCGCCTGGACGTAGGCACCTGGGGCGTGATGGGCGTGGGCATGGGCTACGCGGTCGC CGCC GCGGTCGAAACCGGCAAGCCGGTGCTGGCGCTGTGCGGTGACAGTGCGTTCGGCTTCTCG GGCA TGGAAGTCGAAACGATCTGCCGCTACAACCTGCCGGTCTGCATCGTCATTTTCAACAACA ACGG CGTCTACAAGGGGATCGACGTGAATCCGACCGGCGGCAGGGATCCGGCGGTCACGACGTT CGTC CCGGGCGCGCGCTACGACAAGATGATGGAAGCGTTCGGTGGTGTCGGTGCCAATGTCACC ACGC CGGCGGAACTCGAAGCCGCGGTAAACGAAGCGCTGCGCTCGGGCAAGCCCACGCTGGTCA ACGC CGTCATCGACCCGGCTGCCGGCACCGAAAGCGGTCGCCTGACCAATCTGAATCCGCAAAG CTCG GCCAAGAAGTAA

[00180] SEQ ID NO: 24 (Oxalyl-CoA decarboxylase (OXC) from Escherichia coli MG1655; EC 4.1.1.8; UniProt Accession P0AFI0; Ec_oxc):

ATGTCAGATCAACTTCAAATGACAGATGGTATGCATATCATCGTTGAAGCATTAAAA CAGAATA ATATTGACACTATTTATGGTGTTGTAGGTATTCCTGTGACGGATATGGCACGCCATGCCC AGGC GGAAGGCATTCGTTATATTGGTTTTCGTCATGAGCAGTCGGCAGGCTATGCCGCTGCGGC AAGC GGTTTTCTTACCCAAAAACCGGGGATCTGCCTGACAGTTTCTGCGCCAGGATTCCTCAAT GGTT TGACCGCATTGGCCAACGCAACGGTAAATGGTTTTCCGATGATCATGATTAGCGGCTCCA GCGA CCGCGCGATCGTCGACCTACAGCAAGGTGATTATGAAGAGCTGGACCAAATGAATGCGGC AAAA CCGTATGCCAAAGCAGCATTTCGCGTTAATCAGCCGCAGGATCTTGGCATTGCATTGGCA CGCG CTATCCGGGTTTCTGTATCGGGTCGCCCTGGCGGAGTTTATCTTGATTTGCCAGCAAATG TCCT GGCCGCGACGATGGAAAAAGACGAAGCGTTAACCACGATTGTTAAAGTTGAAAATCCGTC GCCA GCATTATTGCCATGCCCGAAGTCAGTCACTAGCGCAATTTCGCTTTTAGCAAAAGCTGAA CGGC CATTAATTATCCTTGGCAAAGGCGCGGCGTATTCACAAGCTGATGAACAGCTTCGTGAAT TTAT TGAAAGTGCTCAGATTCCATTCCTGCCAATGTCTATGGCGAAAGGGATCCTTGAAGATAC GCAT CCACTTTCTGCGGCAGCTGCGCGTTCGTTTGCCCTGGCAAATGCTGACGTTGTCATGCTT GTTG GTGCACGACTGAATTGGTTATTGGCACACGGTAAAAAAGGATGGGCGGCAGATACACAGT TTAT TCAACTGGATATTGAACCGCAGGAAATTGACAGCAACCGCCCCATTGCTGTGCCAGTCGT TGGT GATATTGCATCCAGTATGCAAGGTATGCTGGCAGAACTGAAACAAAACACATTTACGACT CCAC TGGTATGGCGCGATATTTTAAATATCCACAAGCAGCAAAATGCACAAAAAATGCATGAAA AATT AAGTACAGATACTCAACCATTAAATTACTTTAATGCATTAAGTGCTGTGCGCGACGTATT GCGC GAGAACCAGGATATTTATTTAGTTAATGAAGGTGCAAATACCCTGGATAATGCACGAAAT ATTA TTGATATGTATAAACCACGTCGTCGTCTGGATTGTGGTACCTGGGGTGTCATGGGCATCG GTAT GGGCTATGCCATCGGTGCTAGCGTGACTTCTGGTTCTCCGGTTGTCGCCATTGAAGGTGA TAGT GCTTTTGGTTTCAGTGGGATGGAAATTGAAACGATTTGTCGATATAACCTGCCGGTGACG ATCG TTATTTTTAATAATGGCGGCATCTACAGAGGAGATGGTGTTGATCTCAGTGGCGCTGGTG CACC ATCACCAACGGATCTGTTGCACCATGCAAGGTATGACAAATTAATGGATGCGTTTCGTGG CGTT GGCTATAACGTCACCACGACAGATGAACTTCGTCATGCTTTAACCACCGGTATTCAGTCG CGCA AACCGACCATTATTAATGTGGTCATCGACCCTGCAGCAGGAACTGAAAGTGGCCATATTA CCAA ACTTAACCCAAAACAAGTCGCTGGTAATTAA

[00181] SEQ ID NO: 25 (Oxalyl-CoA decarboxylase (OXC) from Oxalobacter formigenes DSM 4420; EC 4.1.1.8; UniProt Accession P40149; Of_oxc):

ATGAGTAACGACGACAATGTAGAGTTGACTGATGGCTTTCATGTTTTGATCGATGCC CTGAAAA TGAATGACATCGATACCATGTATGGTGTTGTCGGCATTCCTATCACGAACCTGGCTCGTA TGTG GCAAGATGACGGTCAGCGTTTTTACAGCTTCCGTCACGAACAACACGCAGGTTATGCAGC TTCT ATCGCCGGTTACATCGAAGGAAAACCTGGCGTTTGCTTGACCGTTTCCGCCCCTGGCTTC CTGA ACGGCGTGACTTCCCTGGCTCATGCAACCACCAACTGCTTCCCAATGATCCTGTTGAGCG GTTC CAGTGAACGTGAAATCGTCGATTTGCAACAGGGCGATTACGAAGAAATGGATCAGATGAA TGTT GCACGTCCACACTGCAAAGCTTCTTTCCGTATCAACAGCATCAAAGACATTCCAATCGGT ATCG CTCGTGCAGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTGTTTACGTTGACTTGCCAG CAAA ACTGTTCGGTCAGACCATTTCTGTAGAAGAAGCTAACAAACTGCTCTTCAAACCAATCGA TCCA GCTCCGGCACAGATTCCTGCTGAAGATGCTATCGCTCGCGCTGCTGACCTGATCAAGAAC GCCA AACGTCCAGTTATCATGCTGGGTAAAGGCGCTGCATACGCACAATGCGACGACGAAATCC GCGC ACTGGTTGAAGAAACCGGCATCCCATTCCTGCCAATGGGTATGGCTAAAGGCCTGCTGCC TGAC AACCATCCACAATCCGCTGCTGCAACCCGTGCTTTCGCACTGGCACAGTGTGACGTTTGC GTAC TGATCGGCGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAGGCAAAACCTGGGGCGACG AACT GAAGAAATACGTTCAGATCGACATCCAGGCTAACGAAATGGACAGCAACCAGCCTATCGC TGCA CCAGTTGTTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGCAAAGCACTGAAAGGCGCT CCAA AAGCTGACGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTGACGGCAACAAAGCCAAAC TGGC TGGCAAGATGACTGCCGAAACCCCATCCGGAATGATGAACTACTCCAATTCCCTGGGCGT TGTT CGTGACTTCATGCTGGCAAATCCGGATATTTCCCTGGTTAACGAAGGCGCTAATGCACTC GACA ACACTCGTATGATTGTTGACATGCTGAAACCACGCAAACGTCTTGACTCCGGTACCTGGG GTGT TATGGGTATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGTTACCGGCAAACCGGTTAT CGCT GTTGAAGGCGATAGCGCATTCGGTTTCTCCGGTATGGAACTGGAAACCATCTGCCGTTAC AACC TGCCAGTTACCGTTATCATCATGAACAATGGTGGTATCTATAAAGGTAACGAAGCAGATC CACA ACCAGGCGTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTACGACATGATGATGGAAGC ATTT GGCGGTAAAGGTTATGTTGCCAATACTCCAGCAGAACTGAAAGCTGCTCTGGAAGAAGCT GTTG CTTCCGGCAAACCATGCCTGATCAACGCGATGATCGATCCAGACGCTGGTGTCGAATCTG GCCG TATCAAGAGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAATAG

[00182] SEQ ID NO: 26 (Oxalyl-CoA decarboxylase (OXC) from Saccharomyces cerevisiae S288C; EC 4.1.1.8; UniProt Accession P39994; Sc_YEL020C):

ATGACCACGACCGCTACCCAACACTTCGCTCAACTTTTACAAAAATATGGCATCGAC ACAGTCT TTGGAATTGTGGGCATCCCTATTGTCCAACTAGCGGATACGATGGTTGCCAACGGTATCA AATT CATTCCATGCAGGAACGAACAGGCTGCCTCATATGCAGCCTCTGCTTATGGTTATATTAG TGAT AAGCCCGGCGTGTTACTTATTGTCGGGGGCCCCGGTTTAATCCACGCACTGGCTGGTATA TACA ACTCAATGAGTAATAGGTGGCCTCTTCTAGTAATTGCAGGGAGTTCTTCTCAAAGTGATA TACA TAAAGGCGGGTTTCAAGAGTTGGATCAAGTTAGTCTTTTGTCCCCATTTTTGAAGTTTAC CGGA AAGTTAACCCCTGACAATATTGACATGATTACTCAGAAGGCTTTGAATTACTGTATACAA GGCA CTGCAGGGGTTTCTTACATAGACGTCCCTGCAGATTTTATTGAGTATGAAAAACCCTTAG AAGG AAACGACCGTACAGGAAATGAATTACCGATGATATTAACTCCAAACATATGTGGCCCTGA TCCG TCGAAGATCAAAAAAGTCGTACAGCTTATTTTGCAACATAAAAATAAAAATATTCTGATT GTTA TTGGAAAGGGTGCGGTAAAAAACTCACACGAAATCCGCAGACTAGTAAATACGTTCAATC TACC ATTTTTACCCACCCCAATGGCTAAGGGAATTGTCCCAGACTCTTCTCCACTGAACGTTTC ATCT GCAAGATCTCAAGCATTGAAAATAGCGGATATTGTTCTTGTTCTCGGGGCAAGATTAAAC TGGA TATTGCATTTTGGTACTTCACCCAAATGGAACTCAGAATCCATATTCATCCAGTTCGATT CCAA TCCCGAAACCTTGGGGGATAACAATGTCTCACCTGGTGCTGACCTTTCCATATGGGGAGA TATA GGCTTGAGCGTAACCGCTTTAGTTGAGGAATTGACTCGCCAAGATTCCTGCTGGAAGTAT AGTG GTGTTAAGCAAGAAATACGAGAGAAAATTCAACTGAATCAAACTCGTCTATTGAGGAAAG AGAA GACTAGAGGGGCACAATTGAATTACAACCAGGTTTATGGAACATTGAGGCCTCTTATCGA TGAT TACAGGACAATACTTGTGACGGAGGGAGCAAATACTATGGATATTGCGCGTATTTCATTC CCTA CAGACGCTCCAAGGCGCCGTTTAGACGCAGGGACCAACGCGACTATGGGGATTGGGCTCG GATA TGCTCTTGCATGCAAGGCATCTCATCCGGAACTCGATGTGGTGCTGATTCAGGGTGATTC CGCA TTTGGATTCTCTGCCATGGAAATTGAAACGGCAGTAAGGTGTCAGCTGGCATTGGTCATC GTTG TGATGAACAATAGCGGTATTTACCATGGAGAAAAGGATATAGAGGGTGATTTACCTCCAA CGGC ACTAAGCAAGAACTGCCGTTACGATCTCGTAGGCAAAGGACTGGGTGCCAATGATTTTTT TGTC AACACAATAAGCGAACTGAGCAGATGCTTCCAACAAGCCGTGCAGCTTTCTCGGACTAAA AGAG AAACAAGTGTCATCAACGTTATCATTGAGCCTGGCGAACAAAAGCAAATTGCCTTTGCCT GGCA GAATAAACCGCGTTTATGA

[00183] SEQ ID NO: 27 (Oxalyl-CoA reductase / Glyoxylate:NADP+ oxidoreductase (OXR) from Methylobacterium extorquens AM1 / DSM 1338; EC 1.2.1.17; UniProt Accession C5APN9; Me_PanE):

ATGTCAATTGCCATTGTTGGTGCCGGTGCAATTGGAGGATATTTAGGTGTCAGATTA GCTGAAG CTGGTGAGGATGTTACATTCATAGCTAGATCTAATGCTGCAGCCATACAAGCAGATGGAA TGAG ATTGATTGAAGAGGATGGGACCGAAATTCACTCTAAATCTGTCAAAGCCACTCGTTCAAT GCAA GAAGCAGGAGTTCACGAGGTTGTTTTATTAACAGTTAAGGCACACCAAGTTGGTCCTATA GCTG CCGATTTACATCACTTGATAGGTCCAGACACCGTAGTCGTCACTATGCAGAATGGTATTC CTTG GTGGTACTTTCTAGGTGGATACTCTGGAGATCATGCAGGAACAAGGTTGGAATCAGCTGA TCCA GGAGGTTTAATTGCTGATCATTTAGACCCTAAGCATGTCATTGGTTCTGTTGTTTACCCT GCAA CTGTATTGACAGACCCAGGTACTGTTAAAGTTATCGAGGGTAATAGGTTTGGTTTGGGAG AATT GGATGGTTCAAAATCTGAAAGAGTTTTAGCCTTATCTCAGAGGTTAGCAAGGGCCGGTTT TAGA GCCCCAGTCACTTCAGACATTAGAGCAGAGATCTGGTTGAAGTTGTGGGGAAATTTATCT TTCA ATCCCATTAGCGCCTTAACACATGCAACCTTGGAGGACATCTGTAGATTTCCTGATACTA GGGC TATCGCCGCAGAGATGATGAGAGAGGCCGAAGTCATCGCCAATAAATTGGGTGTAACATT TAGA TTAGGAATAGATAAGAGAATAGCTGGAGCTGAAAAGGTCGGTCCACACAAGACCTCTATG TTGC AAGACGTAGAAGCTGGTAGACCAATTGAGTTGGAAGCCTTAGTCGGATCTGTAATCGAAT TAGG AAGGTTAACTGGTACTCCTACTCCACATATTGATACAGTCTTTGCTTTGATGAGATTATT GGCC CAATCTTTAGAAAGAGCACAAGGTAGATTGGCTATTCAGGGAGCATAA [00184] SEQ ID NO: 28 (Putative Succinyl-CoA:oxalate CoA-transferase (SCOCT) from Cupriavidus oxalaticus ATCC 11883; EC 2.8.3.2; Co_ACOCT):

ATGACGCAATCCAACCTGCCCGATTTGCCCGACCTGCCGCTGACCGGCCTGCGCGTG ATCGATT TCTCGCGCGTGCTGGCCGGCCCCTATTGCACCGCGCTGCTCGGCGACCTCGGCGCCGAGG TGAT CAAGGTCGAGCCGCCCGGCGGCGACGACTATCGCGCGGTGGGTCCCTTCGCCGGCGGCAA GAGC GGCCTGTTCTGCGCGATGAACCGCAACAAGCAGAGCATCGTGATCGACCTGAAGACGGAG GACG GCCTGGCTGTCGCCCGCGCGCTGTGCCGCGGTGCCGACGTGGTGGTGGAAAACTTCCGCC CCGG CGTGGCCGACAAGCTTGGCATCGGCTACGCCGCGCTGCGCGAACTGAACCCCTCGCTGGT CTAT GCCAGCGTGTCGGGCTTCGGCCAGACCGGCCCGGAATCGCACCGCCCGGCCTACGACATC ATCC TGCAGGCGATGTGCGGGCTGATGGACGCCACCGGCGCGCCCGACGGCGCGCCGACCATGC TTGG CGAAGCCGTGTCCGATGCGGTCAGCGGCCTGTTCGCCTCGTGGGGCGTGCTGGCCGCGCT GCTG GCGCGCGAGAAGACAGGGCGCGGCACGCATGTCGATGTGTCGATGTTCGATGCCACGCTC AGCC TCAGCGCCACGCTGGTCGCGCGCTACGCGGCCACCGGGCTGGCGCCGCGGCGCGTGGGCA ACCG CCACCCGTCGTCGGCGCCGTTTGGCGCCTACCGCGCCGCGGATGGCTTCTACGTGGTCGC GGTG CTGAACAACAAGCTGTTCCAGGCGCTTGCCGACGCCATCGGCCGGCCCGCGATGGCGCAC GACC CGCGCTTTGCCGATGACGAAACGCGCTGCCGCTTCGAGTCCGACCTGCGCGCCATGCTGG AAAA CTGGTCGGCCACGCGCACGGTGGCGGAGGTGAACGCAGCGCTCGGCGCCGCCGGCATCCC GGTC GCACCGATCCGCAATGTCAAGGAAGCGCTGGAAAGCGAGCACGCGGCGCATCGCCGCCTG CTGA CCGAGGTGCCCGACACGGACGGCGGCACCGTGCGCCTGCCGTCGCAGCCGGTCAAGTTCT CCGC GTACGGCACCAACCGCGTGACGCCCGCGCCGGCACTGGGCCAGCACACCGGGGCCATCCT GGCC GCGCCCGATTTCAGTAATTTCAATAAGGAGAAGCAACATGCATAA [00185] SEQ ID NO: 29 (Putative Succinyl-CoA:oxalate CoA-transferase (SCOCT) from Cupriavidus oxalaticus ATCC 11883; EC 2.8.3.2; Co_CaiB):

ATGGGAGCCTTAAGCCATCTCCGCGTCCTCGACCTGACCCGTGTCCTTGCCGGGCCC TGGTGCG CCCAGAACCTTGCCGACTTCGGCGCCGATGTGATCAAGATCGAGCGCCCCGGCGCCGGCG ACGA CACCCGCACCTGGGGCCCGCCCTGGCTCAAAGACGAAGACGGCCGCGACACCGCCGAGGC CGCC TACTACCTGGCCGCCAACCGCAACAAGCGCTCGGTCACCTGCGACATCAGCACGCCCGAA GGCC AGCAGATCGTGCGCGACCTCGCCGCGCAGAGCGACGTGGTGCTGGAGAACTACAAGGTCG GCCA ACTCAAGAAATACGGGCTGGACTACGAGTCGCTCAGGCAGGTCAAGCCCGACCTGATCTA CTGC TCGGTCACCGGCTTCGGCCAGACCGGCCCGTACGCCGCGCGCCCCGGCTATGACTTCATC ATCC AGGGCATGGGCGGCTTCATGAGCCTGACCGGCGAGCGCGACGACCTGCCCGGCGGCGGCC CGCA GAAGGCCGGCGTGGCGATTTCCGACCTGATGACGGGCCAGTACGCCACCATCGCCGTGCT GGCG GCGCTGGCGCATCGCGAGCGCACCGGCGAAGGCCAGTACATCGACATGGCGCTGCTGGAC GTGC AGGTGGCCATGCTGGCCAACATGAACACCAACTACCTGGCCAGCGGCGAGGCGCCGCGCC GCTG GGGCAATGCGCACCCCAACATCGTGCCCTACCAGACCTTCCAGGCCGCCGACGGCTGGAT CATC GTCGCGGTGGGCAACGACGGGCAGTTCCGCAAGTTCGTCACCGACGGCGGCATGCCCGAA CTGG CCGACGATCCGCGCTTTGCCAAAAACCCGCAGCGCGTGGCCAACCGCGACGTGCTGGTGC CGAT CCTGGCCGAGATGGTGCGCCCGCGCACCCGCGCGCAGTGGATCCGCGACCTGGAAGCCGC GGGC GTGCCGTGCGGCCCGATCAACACGCTCGACGATGTGTTCGAGGACGACCAGGTCAAGGCG CGCG GCCTGCGCGTGGACCTGCCGCACCCCAGCGCCGGCGAGGTCAAGCTGGTCGCCAGCCCGA TCAA GATGAGCGCGACGCCGCCGCAGGCGCTGCGCCACCCGCCGCTGCTGGGCGAGCACACCGA CACG GTGCTGGCCGAAACCCTGGGCTACAGCGCCGGGCAGATCGCGGCACTTCGCGCAAAAGGT GTGC TGTAA [00186] SEQ ID NO: 30 (Putative Succinyl-CoA:oxalate CoA-transferase (SCOCT) from Cupriavidus oxalaticus ATCC 11883; EC 2.8.3.2; Co_SCACT):

ATGGACAAGGAACGCATTCGCCTGGCGAGGCTGCATGACAAGGTAGTCTCGGCCGAC GAGGCCG CCGCGCTGATCCGCGACGGCATGACCGTAGGCATGAGCGGTTTCACCCGCGCGGGCGACT GCAA GGAAGTCCCGTTCGCGCTGGCGCGGCGCGCGGCGACCGAGCCGCTGCGCATCACCCTGAT GACG GGCGCCTCGCTCGGCAACGACATCGACCGCGTCCTGGCCGAGGCCGACGTGATCGCGCGC CGCC TGCCGTTCCAGTCCGATGGCACGCTGCGCCGCAAGATCAACGCCGGCGAGGTGATGTTCA TCGA CCAGCACCTGTCCGAAACCGTCGAGCAGCTGCGTTCCGGCCAGATCGCGCCGGTGGACGT GGCG GTGGTCGAGGCCGTGGCGATTACCGAGCAGGGCGGCATCATCCCCAGCACCTCGGTGGGC AATT CGGCAAGCTTTGCCATGCTGGCGCGCAAGGTGATCGTCGAGATCAACATGAACATGCCGC TGGA GCTGGAAGGGCTGCACGACATCTATTTCCCGGTCCAGCGCCCGTACCGCCAGCCGATCCC GCTG ATCGCGCCGGAACAGCGCATCGGACTCCCGTATATTCCGATCGATCCGGAGAAGATTGCC GCCA TCGTCATCACCGCCAAGGACGACAGCCCGTCCAATGCGCTGCCGCCGGACGACGAAACCC GCAG CATCGCCGGCCACCTCAATGACTTCCTGCTGCGCGAAGTGCGCGCGGGCAAGCTGTCGCC GTCG CTGCAGCCGCTGCAGGCCGGCATCGGCACCATTGCCAATGCCGTGCTGCACGGGCTGGTC GAGT CGCCGTTCCGCGACCTGAAGATGTATTCCGAGGTGCTGCAGGACAGCACCATCGAGTTGC TCGA TGCGGGCCGGCTGTCGTTCGCGTCGGCGTCGTCGGTGACGCTGACGCGCGAGGTCTACCA GCGC TTCCTGTCGAACCTGGACCGCTACCGTTCGCGCCTGCTGCTGCGCCCGCAGGAGATCAGC AACC ATCCCGAGATCCTGCGCCGGCTGGGGCTGATCACCATCAACACCGCGCTGGAGTGCGACA TCTA CGGCAACGTCAACTCCACGCATGTGGGTGGCACGCACATGATGAACGGCATCGGCGGCTC CGGC GACTTTGCGCGCAATGCGCACGTGTCGGTGTTCGTGACCAAGTCGGTGGCCAAGGGCGGC GAAG TCTCGAGCATCGTGCCGATGGTGGCGCACGTGGACCACACCGAGCACGATGTCGACATCA TCGT CACCGAGCACGGCCTGGCCGACCTGCGCGGCCTGGCACCGCGCGAGCGCGCGCGCACCGT CATC GCCAATTGCGCCGATCCGCAATACCGCGAGTTGCTGGGCGACTATTTCCGCCGCGCCAGC GCCC ACGGCGGCCAGACGCCGCACCTGCTGGAAGAGGCGTTGTCCTGGCATGTCGGCTTGCGCG ATCG CGGCACCATGCGGTCCGCACAGCCGGCGCAGGCCCTGGCTGCCTGA [00187] SEQ ID NO: 31 (Putative Succinyl-CoA:oxalate CoA-transferase (SCOCT) from Cupriavidus oxalaticus ATCC 11883; EC 2.8.3.2; Co_SCMCT): ATGGTCAACGAAGCGAACAAGGAAAAGATGCCGCTGCAAGGCGTGCGCGTGTTGGAGCTG GGAT CGCTGATCGCCGGCCCGTATGCCGGCGGCCTGCTCGCCCAGTTCGGCGCCGAGGTGCTGA AGAT CGAAGCGCCGGGCGAAGGCGATCCGCTGCGCAAATGGCGCAAGCTGTACGAGGGCACCTC GCTG TGGTGGTACAGCCAGAGCCGCAACAAGAAGTCGCTGACGCTGGACCTGCGCAGCGCGCAA GGCC AGGACATCGTGCGCAAGCTGGTGGCCGGCGCCGATATCGTGATCGAGAACTTCCGCCCCG GCAC GCTGGAGAAATGGGGCCTGGGCTGGGAAGACCTGCGCAAGGTGAATCCGGCCCTGGTCAT GGTG CGCATTTCCGGCTATGGCCAGACCGGCCCCTACAAGGACCGCCCGGGGTTTGCCGCGATC GCGG AATCGATGGGCGGGCTGCGCTATGTCAGCGGCTACCCCGACCGGCCGCCGGTGCGGTCCG GCGT CAGCATCGGCGACACGCTGGCGTCGCTGTACGGCGTGATCGGCGCGCTGCTGGCCATGCA CCAT CTGCGCAACAACGATGGCGAAGGGCAGTTTGTGGACGTGGCCCTGTACGAGTCGGTCTTT GCCG TGATGGAAAGCCTGGTGCCGGAGTTCGACAAGTTCGGCCATGTGCGCGAGCGTTCCGGCG CCAG CCTCCCCGGCATTTCGCCGTCGAACACATATCCCTGCCAGGATGGACAGTACGTGATCAT CGCG GGCAATGGCGACGCCATCTTCCGGCGCTTCATGACGGCGATCGGCCGCGACGACCTCGGC CAGG ATCCGCGCCTGGCTCACAACGATGGCCGCGTGCAGCACAACGCCATGCTCGACGACGCCA TCGC CGCATGGACCGCCGCGCACGACCTCGACACCGTGCTGGCGACGCTGGAAGCCGCGGCGGT GCCT TGCGGGCGCATCTACACCGCGCAGGACATCTGCAGCGACCCCCACTACAGTGCGCGCGGC ATGA TCGAGCCGCACCAGCTTCCGGACGGCTCGCCGCTGGCCCTGTCGGGCATCGTGCCCAGGC TCAG TGAAACCCCCGGGCGTACCAACTGGATCGGCCCGGCGCTGGGCGAGCACACCGAAGAGAT CCTG GCGGGCATCGGCATTGCCGGCGCCGAATTCCGCGCGCTGCGCGAGGCCGGCGTGGTCTGA [00188] SEQ ID NO: 32 (Acetyl-CoA:oxalate CoA-transferase (ACOCT) from Acetobacter aceti strain 1023; EC 2.8.3.19; UniProt Accession A9X6P9; Aa_CoAT3):

MTETTPAKPKGPFDGLLVIDLTHVLNGPFGTTILTDLGARTIKIEPPGHGDDTRTYG PYVGDQS LYFSFVNRGKESIVLNLKDEGDRAIFLEMVRKADVLAENFRPGVMDRLGFNYEELAKINP RLIY ASSSGFGQTGPLAHYPAYDTIVQAMSGIMMATGFPDGPPTRVGGTSLSDLCGGVFMFCGI ASAL YARERTGKGAHIDVSMFDGTLAFLQHALMCWSATGKAPARIGNRHPYMAPFDVFQAQDKP FVIC CGNDHLFKALCDVIGAPELATDPRFVENHDRMANNDALKAALEKALSKQPAAHWLDVIHK AGVP VGPLLDVAEAANLPQTAARNMLIKSGGVMMPGNPVKISGYDDPHERPGAPKLDEQGAALR KEFA APEAK [00189] SEQ ID NO: 33 (Acetyl-CoA:oxalate CoA-transferase (ACOCT) from Escherichia coli MG1655; EC 2.8.3.19; UniProt Accession P76518; Ec_yfdE):

MTNNESKGPFEGLLVIDMTHVLNGPFGTQLLCNMGARVIKVEPPGHGDDTRTFGPYV DGQSLYY SFINHGKESVVLDLKNDHDKSIFINMLKQADVLAENFRPGTMEKLGFSWETLQEINPRLI YASS SGFGHTGPLKDAPAYDTIIQAMSGIMMETGYPDAPPVRVGTSLADLCGGVYLFSGIVSAL YGRE KSQRGAHVDIAMFDATLSFLEHGLMAYIATGKSPQRLGNRHPYMAPFDVFNTQDKPITIC CGND KLFSALCQALELTELVNDPRFSSNILRVQNQAILKQYIERTLKTQAAEVWLARIHEVGVP VAPL LSVAEAIKLPQTQARNMLIEAGGIMMPGNPIKISGCADPHVMPGAATLDQHGEQIRQEFS S [00190] SEQ ID NO: 34 (Formate dehydrogenase from Saccharomyces cerevisiae S288C; EC 1.2.1.2; UniProt Accession Q08911; Sc_FDH1): MSKGKVLLVLYEGGKHAEEQEKLLGCIENELGIRNFIEEQGYELVTTIDKDPEPTSTVDR ELKD AEIVITTPFFPAYISRNRIAEAPNLKLCVTAGVGSDHVDLEAANERKITVTEVTGSNVVS VAEH VMATILVLIRNYNGGHQQAINGEWDIAGVAKNEYDLEDKIISTVGAGRIGYRVLERLVAF NPKK LLYYDYQELPAEAINRLNEASKLFNGRGDIVQRVEKLEDMVAQSDVVTINCPLHKDSRGL FNKK LISHMKDGAYLVNTARGAICVAEDVAEAVKSGKLAGYGGDVWDKQPAPKDHPWRTMDNKD HVGN AMTVHISGTSLDAQKRYAQGVKNILNSYFSKKFDYRPQDIIVQNGSYATRAYGQKK [00191] SEQ ID NO: 35 (Formyl-CoA:oxalate CoA-transferase (FCOCT) from

Bifidobacterium animalis subsp. lactis DSM 10140; EC 2.8.3.16; UniProt Accession B9X295; Ba_frc):

MADKSTAPLAGIKVIDWTQVQSGPSCTQILAWLGAEVIKLEKVHGGDPTRNEMNDVD GSYSLYF LQLNANKKSITLDMKDPEGKKILTDLLKDADVFVENIGPGDVEKLGFGWDEVHKINPKLI MASL KGFNQGSRFEHVKAFEPVAQCAGGAASTTGWWEGDKNIPTQSGAALGDSNTGMHLTIAIL TALL QRERTGEGVFVYQSMQNAVLNLCRIKLRDQLILDHLHQLSYYDCYPGYKFGKAIPRAANA EGGL VLGWCYRAKGWETDPNAYVYIVIQQSQKGFENFCNAMGFQDWLTDPKFSTPNARDEHKQE VYKR VEEYTMQYDKYTLTKELGAKGVPVGPVLDWNELENDPDLNEDGTLITIDQGDARGKFKTI GLPF TMSNYAPDYQRAPKLGENNEEILKSLGYTDEQIADLATKGVIGSNDGVKADLTAAPAQA [00192] SEQ ID NO: 36 (Formyl-CoA:oxalate CoA-transferase (FCOCT) from Cupriavidus oxalaticus ATCC 11883; EC 2.8.3.16; Co_frc1):

MPAQHTHATPAGPLDGIRVLDLTAVVLGPLATQVLADFGADVIKIEGPEGDLMRANG VSQHAGM SSIYLALNRNKRSVVLDLKIPEGAEALRALIAGADVLVHNMRVAAIERLGFGYEAVARIN PRIV YCVATGFGQDGPHRDKPAFDDIIQAGCGLVALGAGNGERPEYVPSLIADKTTGLALANAV LAAL LHRERHGVGQSVEVPMLETMAAFVMTEHLGGLTFEPAPAGAGYARLLQGGRRPAPTRDGW ICAL PYTERHWHAFFRAVGRDDLADRYEVGDRAQRNANIRALYGHLAELTPERSTAEWMALFEA LDIP ATPIYDLDALVDHPHLRAVGLFQATQHPTEGPLREVRPAARFSATPLSLRRHAPALGEHT AEVL QEAGIALPAAHAGTPAGAQE [00193] SEQ ID NO: 37 (Formyl-CoA:oxalate CoA-transferase (FCOCT) from Cupriavidus oxalaticus ATCC 11883; EC 2.8.3.16; Co_frc2):

MNLPLNGIKIIDFTHVQAGPACTQLLAWFGADVIKVERPGSGDVTRTQLRDIPDVDA LYFTMLN SNKRSLTLDTKKPEGKKILEQLIRESDVLVENFGPGALDRMGFSWERINELNPKMIVASV KGFS DGHHYEDLKVYENVAQCAGGAASTTGFWDGPPTVSAAALGDSNTGMHLAIGILTALIGRD KTGK GQKVAVSMQDAVLNLCRVKLRDQQRLDRLGFLEEYPQYPHGSFSDVVPRGGNAGGGGQPG WVLK CKGWETDPNAYIYFTIQGHAWEPICKALGKPEWIDDPNYATAKARQPHIFDIFNTIEEWL ADKT KYEAVDILRKHDIPCSPVLSMKEIAADPSLRASGSITEVPHKERGTYLTVGSPIKFSDLK PEIT GSPLLGEHSEEVLAGLGYGTDDIKRLRESQVI [00194] SEQ ID NO: 38 (Formyl-CoA:oxalate CoA-transferase (FCOCT) from Escherichia coli MG1655; EC 2.8.3.16; UniProt Accession P69902; Ec_frc): MSTPLQGIKVLDFTGVQSGPSCTQMLAWFGADVIKIERPGVGDVTRHQLRDIPDIDALYF TMLN SNKRSIELNTKTAEGKEVMEKLIREADILVENFHPGAIDHMGFTWEHIQEINPRLIFGSI KGFD ECSPYVNVKAYENVAQAAGGAASTTGFWDGPPLVSAAALGDSNTGMHLLIGLLAALLHRE KTGR GQRVTMSMQDAVLNLCRVKLRDQQRLDKLGYLEEYPQYPNGTFGDAVPRGGNAGGGGQPG WILK CKGWETDPNAYIYFTIQEQNWENTCKAIGKPEWITDPAYSTAHARQPHIFDIFAEIEKYT VTID KHEAVAYLTQFDIPCAPVLSMKEISLDPSLRQSGSVVEVEQPLRGKYLTVGCPMKFSAFT PDIK AAPLLGEHTAAVLQELGYSDDEIAAMKQNHAI

[00195] SEQ ID NO: 39 (Formyl-CoA:oxalate CoA-transferase (FCOCT) from Oxalobacter formigenes DSM 4420; EC 2.8.3.16; UniProt Accession O06644; Of_frc):

MTKPLDGINVLDFTHVQAGPACTQMMGFLGANVIKIERRGSGDMTRGWLQDKPNVDS LYFTMFN CNKRSIELDMKTPEGKELLEQMIKKADVMVENFGPGALDRMGFTWEYIQELNPRVILASV KGYA EGHANEHLKVYENVAQCSGGAAATTGFWDGPPTVSGAALGDSNSGMHLMIGILAALEMRH KTGR GQKVAVAMQDAVLNLVRIKLRDQQRLERTGILAEYPQAQPNFAFDRDGNPLSFDNITSVP RGGN AGGGGQPGWMLKCKGWETDADSYVYFTIAANMWPQICDMIDKPEWKDDPAYNTFEGRVDK LMDI FSFIETKFADKDKFEVTEWAAQYGIPCGPVMSMKELAHDPSLQKVGTVVEVVDEIRGNHL TVGA PFKFSGFQPEITRAPLLGEHTDEVLKELGLDDAKIKELHAKQVV [00196] SEQ ID NO: 40 (Oxalate decarboxylase (OXDC) from Bacteroides subtilis 168; EC 4.1.1.2; UniProt Accession O34714; Bs_oxdC):

MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGTVSNMKFSFSDTHN RLEKGGY AREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEWAYMIYGSARVTIVDEKGRSFID DVGE GDLWYFPSGLPHSIQALEEGAEFLLVFDDGSFSENSTFQLTDWLAHTPKEVIAANFGVTK EEIS NLPGKEKYIFENQLPGSLKDDIVEGPNGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFK VSKT IASALVTVEPGAMRELHWHPNTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFA MGHY VENIGDEPLVFLEIFKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVK KKCS

K [00197] SEQ ID NO: 41 (Oxalate oxidase (OXO) from Hordeum vulgare; EC 1.2.3.4; UniProt Accession P45850; Hv_OxOx):

MSDPDPLQDFCVADLDGKAVSVNGHTCKPMSEAGDDFLFSSKLTKAGNTSTPNGSAV TELDVAE WPGTNTLGVSMNRVDFAPGGTNPPHIHPRATEIGMVMKGELLVGILGSLDSGNKLYSRVV RAGE TFVIPRGLMHFQFNVGKTEAYMVVSFNSQNPGIVFVPLTLFGSDPPIPTPVLTKALRVEA GVVE LLKSKFAGGS [00198] SEQ ID NO: 42 (Oxalate oxidoreductase (OOR) alpha subunit from Moorella thermoacetica ATCC 39073; EC 1.2.7.10; UniProt Accession Q2RI41; Mt_OORA!):

MGKVRNISGCVAVAHGVRLADVDVICSYPIRPYTGIMSELARMVADGELDAEFVHGE GEHAQLS VVYGASAAGARVFTGSSGVGVTYAMEVYSPISGERLPVQMAIADRTLDPPGDFGEEHTDA ECCR DQGWIQGWASTPQEALDNTLIYYRVGEDQRVLLPQYACLDGYFVSHILGPVDIPDEAQVK EFLP PYKNHHVLDPRKPQIIGPQIEPAMGPPLQYQRYQAVKGVHKVLEEACDEFARIFGRKYDP YLDE YLTDDAEVIIFGQGAHMETAKAVARRLRNLGEKVGVARLRTFRPFPTEQIKERLSKFKAI GVLD VSANFGISCSGGVLLSELRAALYDYGDKVKTVGFVAGLGGEVVTHDEFYRMFQKLKEIAK TGKV EQTSYWIPFEL [00199] SEQ ID NO: 43 (Oxalate oxidoreductase (OOR) beta subunit from Moorella thermoacetica ATCC 39073; EC 1.2.7.10; UniProt Accession Q2RI42; Mt_OORB):

MMDRIASIKKAPDEEYYVPGHRTCAGCGPALTYRLVAKAAGPNTIFIGPTGCMYVAN TSYGCGP WRVPWIHAQITNGGAVASGIEAAYKAMIRKKKTDAEFPNIIVMAGDGGAVDIGLQALSAM LYRG HDVLFICYDNESYANTGIQTSPTTPYGANTTFTPPGEVVPEGKKLFPKDNPKVIAHGHPE LKYV ATASIGWPVDLMNKVRKGLNQEGPAYIHIHAPCPKGWQFPADKTIEMAKLAVQTGMFQLY EYEN GEYKLSVKVDKRKPVSEYMKLQKRFAHLKPEHIAKMQAFVDARCAEVGITVPVVASNA [00200] SEQ ID NO: 44 (Oxalate oxidoreductase (OOR) delta subunit from Moorella thermoacetica ATCC 39073; EC 1.2.7.10; UniProt Accession Q2RI40; Mt_OORD):

MSTKDLFAEPNLKQITVWARGVVMNKDARDIVVALTEAAAKEGKYVQAWENYVDLPD RIYVPVR AYARISSDPIESKYIYENETPDIVVLVEESLIKGVPILKGIRPGSTLVVNTKRSIDTILE FLGD TGNLAQIVTVDANSMAEAVMTLSGAEGATDATGIGAGIAAPIAGAVVKATGIVDVENLAA VVKN PAAMRRGYAEAQVRQLPPHEAVEEAAVSATELLRQMPFAGTVPSPVTENEGMVTGNWRIQ RPII DREACTECYTCWIYCPDSCITRTEEGPVFNMKYCKGCGLCTAVCPSGALTNVPELDFKD [00201] SEQ ID NO: 45 (Oxalate--CoA ligase / Oxalyl-CoA synthetase (OXS) from Arabidopsis thaliana col-1; EC 6.2.1.8; UniProt Accession Q9SMT7; At_AAE3):

MDSDTLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGD VVALTFP NTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKL KISH VTATLLDAGSDLVLSVADSDSVVDSATELVNHPDDGALFLHTSGTTSRPKGVPLTQLNLA SSVK NIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDMKKY NATW YTAVPTIHQIILDRHASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGAPVLEAYAMTE ATHL MSSNPLPEEGPHKPGSVGKPVGQEMAILNEKGEIQEPNNKGEVCIRGPNVTKGYKNNPEA NKAG FEFGWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGV PDEK YGEEINCAVIPREGTTVTEEDIKAFCKKNLAAFKVPKRVFITDNLPKTASGKIQRRIVAQ HFLE KP [00202] SEQ ID NO: 46 (Oxalate--CoA ligase / Oxalyl-CoA synthetase (OXS) from Methylobacterium extorquens AM1 / DSM 1338; EC 6.2.1.8; UniProt Accession C5APP0; Me_oxs):

MTMLLPEPSALLPTDSKEASVPATTLHELIQAGADAAPALSSPGGVPLTFQALRALT ERTVADL NARGIGRGDRVAIVLPNGPEMAAAFIAVAAGTTSAPLNPSYKADEFEFYMSDLGAKLLLV AEGS ETPAVAVAEKLGVSVARLRPTPDEGAGSFTLHFASESTGPTEKSGPAGSDDIALVLHTSG TTSR LKFFGWMDEVNPTWYTGVPTMHQAILGRAARNKEIIARNPLRFIRSSSSSLPPQVMKELE ETFG APVIEAYGMTEAAHQMASNPLPPKPHYAGSVGLAAGPEIAVVDLDGEPLPAGETGEIVIR GDNV MKGYENNEKANAEAFTKQGWFRTGDQGVLSPEGYLSITGRLKEIINRGGEKISPREVDEI LMDH PAVSQCVTFAVPHDKLGEDVAAAIVLREGVEAVEKDIRSFASERLAAFKVPAKILILDEI PKGA TGKLQRIGLAQKLGLV [00203] SEQ ID NO: 47 (Oxalate--CoA ligase / Oxalyl-CoA synthetase (OXS) from Saccharomyces cerevisiae S288C; EC 6.2.1.8; UniProt Accession P38137; Sc_YBR222C): MTSAATVTASFNDTFSVSDNVAVIVPETDTQVTYRDLSHMVGHFQTMFTNPNSPLYGAVF RQDT VAISMRNGLEFIVAFLGATMDAKIGAPLNPNYKEKEFNFYLNDLKSKAICVPKGTTKLQS SEIL KSASTFGCFIVELAFDATRFRVEYDIYSPEDNYKRVIYRSLNNAKFVNTNPVKFPGFARS SDVA LILHTSGTTSTPKTVPLLHLNIVRSTLNIANTYKLTPLDRSYVVMPLFHVHGLIGVLLST FRTQ GSVVVPDGFHPKLFWDQFVKYNCNWFSCVPTISMIMLNMPKPNPFPHIRFIRSCSSALAP ATFH KLEKEFNAPVLEAYAMTEASHQMTSNNLPPGKRKPGTVGQPQGVTVVILDDNDNVLPPGK VGEV SIRGENVTLGYANNPKANKENFTKRENYFRTGDQGYFDPEGFLVLTGRIKELINRGGEKI SPIE LDGIMLSHPKIDEAVAFGVPDDMYGQVVQAAIVLKKGEKMTYEELVNFLKKHLASFKIPT KVYF VDKLPKTATGKIQRRVIAETFAKSSRNKSKL [00204] SEQ ID NO: 48 (Oxalate:formate antiporter (oxlT) from Bifidobacterium animalis subsp. lactis DSM 10140; UniProt Accession B9X293; Ba_OxlT):

MTKILIDDIIPIIVIMALGYVCGKLSYFDNDQRQGLNKLVLNIALPAALFISIVKAT REMLAQD AVLTILGFIGIIVMFMLSYYLCRLMFHHSIQEAAVCALIAGSPTIGFLGFAVLDPIYGDT VSTN LVIAIISIVVNAVTIPIGMYLINLGQSKDRERLSKAAVTNSKGQVSIANPKDDIAVDPNK DAKT DKTAEVMISKSSNMGKKKNQNLEALINALKQPVCWAPLLAIVLVLIGVRVPSGFAPTFDL IAKA NSGVAVLAAGLALSTVKFSLGWETIWNTFYRLILTPAAFLGVGLLLGMGSNVNKLSMLVM AVAL PPAFSGIIISSRYNIYVKEGASTTAVSTVAFAVTCLLWIWLVPLCCH [00205] SEQ ID NO: 49 (Oxalate:formate antiporter (oxlT) from Cupriavidus oxalaticus ATCC 11883; Co_OxlT1):

MSNATAGALSPNQGASESTRWIQLLVGVVCMIATANIQYAWTLFVPEIQDTYGWSRA SIQIAFT VFVLVQTWLAPIEGYFIDKFGPRMMVAFGALFIGTAWVINSQATTLMGFYVGAAVGGLGV GSIY ATCINNALKWFPDRRGLAVGLTAGGYGAGSAATILPIAAMIESQGFQHTFLFFGLLQGSL AFVA AWFLRSPKTGEVRGSKKLAQATRDYTLKEALCTRLFWLMLVMFVLVVTGGMMAVAQLGVI AKDL GVKEFQVDLHFFVMAALPLALMLDRIMNGISRPLFGWISDNIGREKTMVIAFTLEGLGII ALGY FGSNPYAFLILSGVVFLAWGEVYSLFSALAGDAFGTKHIGKIYGVLYTAKGIGALFVPIG NLLM EATGTWSTVLYTVAVMDLTAAFLAIMVLRPVLASHVATSRQRFAQESAAAGAQVAA [00206] SEQ ID NO: 50 (Oxalate:formate antiporter (oxlT) from Cupriavidus oxalaticus ATCC 11883; Co_OxlT2): MELQQRESTSRFASPWVQLVFGVICMAMIANMQYGWTLFVNPIDDKYHWGRTAIQVAFTI FVVT ETWLVPIEGYLVDKYGPRPVVVGGGLLCAIAWALNSVASSLPMLYFAAAIGGVGAGAVYG TCVG NALKWFPNRRGLAAGITAAGFGAGSAMTVVPIANMIKTSGYEATFLWFGLGQGLIVFILG LALY PPSARILSEVKTTLKAAATYNATPRQVLKSPIFWIMYAMFVMMAAGGLMATAQLGPIAKD FGLH DSPVSILGLTLPALTFALTIDRVLNGLTRPFFGWISDHIGRERTMFFAFAVEAVGILLLS KYGH NPVAFVVLTGIVFFAWGEIYSLFPATCGDTFGPKFAATNAGLLYTAKGTAALLVPFSSVI TAAT GDWHAVFMLASGMAALSAVLALFVLKPMREAHARKYVHANTAAPMGYRAVQEDLT

[00207] SEQ ID NO: 51 (Oxalate:formate antiporter (oxlT) from Escherichia coli MG1655; UniProt Accession P37662; Ec_YhjX):

MTPSNYQRTRWLTLIGTIITQFALGSVYTWSLFNGALSAKLDAPVSQVAFSFGLLSL GLAISSS VAGKLQERFGVKRVTMASGILLGLGFFLTAHSDNLMMLWLSAGVLVGLADGAGYLLTLSN CVKW FPERKGLISAFAIGSYGLGSLGFKFIDTQLLETVGLEKTFVIWGAIALLMIVFGATLMKD APKQ EVKTSNGVVEKDYTLAESMRKPQYWMLAVMFLTACMSGLYVIGVAKDIAQSLAHLDVVSA ANAV TVISIANLSGRLVLGILSDKIARIRVITIGQVISLVGMAALLFAPLNAVTFFAAIACVAF NFGG TITVFPSLVSEFFGLNNLAKNYGVIYLGFGIGSICGSIIASLFGGFYVTFYVIFALLILS LALS TTIRQPEQKMLREAHGSL [00208] SEQ ID NO: 52 (Oxalate:formate antiporter (oxlT) from Oxalobacter formigenes DSM 4420; UniProt Accession Q51330; Of_oxlT):

MNNPQTGQSTGLLGNRWFYLVLAVLLMCMISGVQYSWTLYANPVKDNLGVSLAAVQT AFTLSQV IQAGSQPGGGYFVDKFGPRIPLMFGGAMVLAGWTFMGMVDSVPALYALYTLAGAGVGIVY GIAM NTANRWFPDKRGLASGFTAAGYGLGVLPFLPLISSVLKVEGVGAAFMYTGLIMGILIILI AFVI RFPGQQGAKKQIVVTDKDFNSGEMLRTPQFWVLWTAFFSVNFGGLLLVANSVPYGRSLGL AAGV LTIGVSIQNLFNGGCRPFWGFVSDKIGRYKTMSVVFGINAVVLALFPTIAALGDVAFIAM LAIA FFTWGGSYALFPSTNSDIFGTAYSARNYGFFWAAKATASIFGGGLGAAIATNFGWNTAFL ITAI TSFIAFALATFVIPRMGRPVKKMVKLSPEEKAVH [00209] SEQ ID NO: 53 (Oxalyl-CoA decarboxylase (OXC) from Bifidobacterium animalis subsp. lactis DSM 10140; EC 4.1.1.8; UniProt Accession B9X297; Ba_oxc):

MVDVSVTATSSDQNLTDSPHYLAETLIKNGVKHMYGVVGIPVTDFARIAQGMGIRFI GMRHEED AVNAAAAEGFLTGRPAVALTVSAPGFLNGLAPLLEATTNGFPVIMIGGSSTRHVVDMHEG EYEG LDQMNYAKQFCKESFRIDKIEDIPLAVARAMHIACSGRPGGVYIDFPDDAVAQTLDKDVA ESQL WVANQPAPAMPPAQSSVDEALKLLSEAKNPLMLVGKGAALAQAEDELREFVEKTDMPFQP MSMA KGVIPDDDPHCTASCRGLALRTADVVLLVGARLNWMLNFGEGKEWNPNVKFIQIDIDPNE IENA RSIACPVVGDIKSAMQMINAGLEKTPVKASAQWLDMLKADAEKNDAKFAARVNSNTVPMG HYDA LGAIKKVYDQHKDMILTNEGANTLDDCRNIIDIYQPRHRLDCGTWGVMGCAVGYSIGAAV ATGK PVLYVGGDSGFGFDGMEVEVACRYNLPITFVVLNNGGIYRGDFENLGDDGDPSPLTLSYD AHYE RMIEAFGGNGYYATTPAEVEQMVGEAVASGKPSLVHVQLADYAGKESGHISNLNPKPVVG PLAT SEMTANPYLKGAHM [00210] SEQ ID NO: 54 (Oxalyl-CoA decarboxylase (OXC) from Cupriavidus oxalaticus ATCC 11883; EC 4.1.1.8; Co_oxc):

MAEVGNELQRHAAEEHQAQTDGFHLVIDALKLNGIENIYGLPGIPVTDLARLAQANG MRVISFR HEQNAGNAAAIAGFLTQKPGVCLTVSAPGFLNGLTALAHATTNCFPMILISGSSEREIVD LQQG DYEEMDQLAIARPHAKAAFRVLHAEDIGVGIARAIRAAVSGRPGGVYLDLPAKLLGQSME AEKG RKSLIKVVDPAPRQLPAPDSVDRAVALLKSAKRPLILVGKGAAYARAEADIRTLVEKTGI PYLP MSMAKGLLPDTHPQSASAARSYVLAEADVVLLVGARLNWLLSHGKGKTWGKPKQFIQIDI APTE MDSNVAIAAPVVGDIGSCVSAILDKVGDDFARPGADWLNAVADRRDTNLAKMAETLARSR DASP MNFHGALGVLKDVVKANPNISFVNEGANTLDYARAVIDMYEPRKRLDVGTWGVMGVGMGY AVAA AVETGKPVLALCGDSAFGFSGMEVETICRYNLPVCIVIFNNNGVYKGIDVNPTGGRDPAV TTFV PGARYDKMMEAFGGVGANVTTPAELEAAVNEALRSGKPTLVNAVIDPAAGTESGRLTNLN PQSS AKK [00211] SEQ ID NO: 55 (Oxalyl-CoA decarboxylase (OXC) from Escherichia coli MG1655; EC 4.1.1.8; UniProt Accession P0AFI0; Ec_oxc):

MSDQLQMTDGMHIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEGIRYIGFRHEQSA GYAAAAS GFLTQKPGICLTVSAPGFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEELDQM NAAK PYAKAAFRVNQPQDLGIALARAIRVSVSGRPGGVYLDLPANVLAATMEKDEALTTIVKVE NPSP ALLPCPKSVTSAISLLAKAERPLIILGKGAAYSQADEQLREFIESAQIPFLPMSMAKGIL EDTH PLSAAAARSFALANADVVMLVGARLNWLLAHGKKGWAADTQFIQLDIEPQEIDSNRPIAV PVVG DIASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMHEKLSTDTQPLNYFNALSAVR DVLR ENQDIYLVNEGANTLDNARNIIDMYKPRRRLDCGTWGVMGIGMGYAIGASVTSGSPVVAI EGDS AFGFSGMEIETICRYNLPVTIVIFNNGGIYRGDGVDLSGAGAPSPTDLLHHARYDKLMDA FRGV GYNVTTTDELRHALTTGIQSRKPTIINVVIDPAAGTESGHITKLNPKQVAGN [00212] SEQ ID NO: 56 (Oxalyl-CoA decarboxylase (OXC) from Oxalobacter formigenes DSM 4420; EC 4.1.1.8; UniProt Accession P40149; Of_oxc):

MSNDDNVELTDGFHVLIDALKMNDIDTMYGVVGIPITNLARMWQDDGQRFYSFRHEQ HAGYAAS IAGYIEGKPGVCLTVSAPGFLNGVTSLAHATTNCFPMILLSGSSEREIVDLQQGDYEEMD QMNV ARPHCKASFRINSIKDIPIGIARAVRTAVSGRPGGVYVDLPAKLFGQTISVEEANKLLFK PIDP APAQIPAEDAIARAADLIKNAKRPVIMLGKGAAYAQCDDEIRALVEETGIPFLPMGMAKG LLPD NHPQSAAATRAFALAQCDVCVLIGARLNWLMQHGKGKTWGDELKKYVQIDIQANEMDSNQ PIAA PVVGDIKSAVSLLRKALKGAPKADAEWTGALKAKVDGNKAKLAGKMTAETPSGMMNYSNS LGVV RDFMLANPDISLVNEGANALDNTRMIVDMLKPRKRLDSGTWGVMGIGMGYCVAAAAVTGK PVIA VEGDSAFGFSGMELETICRYNLPVTVIIMNNGGIYKGNEADPQPGVISCTRLTRGRYDMM MEAF GGKGYVANTPAELKAALEEAVASGKPCLINAMIDPDAGVESGRIKSLNVVSKVGKK [00213] SEQ ID NO: 57 (Oxalyl-CoA decarboxylase (OXC) from Saccharomyces cerevisiae S288C; EC 4.1.1.8; UniProt Accession P39994; Sc_YEL020C): MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYG YISD KPGVLLIVGGPGLIHALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFL KFTG KLTPDNIDMITQKALNYCIQGTAGVSYIDVPADFIEYEKPLEGNDRTGNELPMILTPNIC GPDP SKIKKVVQLILQHKNKNILIVIGKGAVKNSHEIRRLVNTFNLPFLPTPMAKGIVPDSSPL NVSS ARSQALKIADIVLVLGARLNWILHFGTSPKWNSESIFIQFDSNPETLGDNNVSPGADLSI WGDI GLSVTALVEELTRQDSCWKYSGVKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRP LIDD YRTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQ GDSA FGFSAMEIETAVRCQLALVIVVMNNSGIYHGEKDIEGDLPPTALSKNCRYDLVGKGLGAN DFFV NTISELSRCFQQAVQLSRTKRETSVINVIIEPGEQKQIAFAWQNKPRL [00214] SEQ ID NO: 58 (Oxalyl-CoA reductase / Glyoxylate:NADP+ oxidoreductase (OXR) from Methylobacterium extorquens AM1 / DSM 1338; EC 1.2.1.17; UniProt Accession C5APN9; Me_PanE):

MSIAIVGAGAIGGYLGVRLAEAGEDVTFIARSNAAAIQADGMRLIEEDGTEIHSKSV KATRSMQ EAGVHEVVLLTVKAHQVGPIAADLHHLIGPDTVVVTMQNGIPWWYFLGGYSGDHAGTRLE SADP GGLIADHLDPKHVIGSVVYPATVLTDPGTVKVIEGNRFGLGELDGSKSERVLALSQRLAR AGFR APVTSDIRAEIWLKLWGNLSFNPISALTHATLEDICRFPDTRAIAAEMMREAEVIANKLG VTFR LGIDKRIAGAEKVGPHKTSMLQDVEAGRPIELEALVGSVIELGRLTGTPTPHIDTVFALM RLLA QSLERAQGRLAIQGA [00215] SEQ ID NO: 59 (Putative Succinyl-CoA:oxalate CoA-transferase (SCOCT) from Cupriavidus oxalaticus ATCC 11883; EC 2.8.3.2; Co_ACOCT):

MTQSNLPDLPDLPLTGLRVIDFSRVLAGPYCTALLGDLGAEVIKVEPPGGDDYRAVG PFAGGKS GLFCAMNRNKQSIVIDLKTEDGLAVARALCRGADVVVENFRPGVADKLGIGYAALRELNP SLVY ASVSGFGQTGPESHRPAYDIILQAMCGLMDATGAPDGAPTMLGEAVSDAVSGLFASWGVL AALL AREKTGRGTHVDVSMFDATLSLSATLVARYAATGLAPRRVGNRHPSSAPFGAYRAADGFY VVAV LNNKLFQALADAIGRPAMAHDPRFADDETRCRFESDLRAMLENWSATRTVAEVNAALGAA GIPV APIRNVKEALESEHAAHRRLLTEVPDTDGGTVRLPSQPVKFSAYGTNRVTPAPALGQHTG AILA APDFSNFNKEKQHA [00216] SEQ ID NO: 60 (Putative Succinyl-CoA:oxalate CoA-transferase (SCOCT) from Cupriavidus oxalaticus ATCC 11883; EC 2.8.3.2; Co_CaiB):

MGALSHLRVLDLTRVLAGPWCAQNLADFGADVIKIERPGAGDDTRTWGPPWLKDEDG RDTAEAA YYLAANRNKRSVTCDISTPEGQQIVRDLAAQSDVVLENYKVGQLKKYGLDYESLRQVKPD LIYC SVTGFGQTGPYAARPGYDFIIQGMGGFMSLTGERDDLPGGGPQKAGVAISDLMTGQYATI AVLA ALAHRERTGEGQYIDMALLDVQVAMLANMNTNYLASGEAPRRWGNAHPNIVPYQTFQAAD GWII VAVGNDGQFRKFVTDGGMPELADDPRFAKNPQRVANRDVLVPILAEMVRPRTRAQWIRDL EAAG VPCGPINTLDDVFEDDQVKARGLRVDLPHPSAGEVKLVASPIKMSATPPQALRHPPLLGE HTDT VLAETLGYSAGQIAALRAKGVL [00217] SEQ ID NO: 61 (Putative Succinyl-CoA:oxalate CoA-transferase (SCOCT) from Cupriavidus oxalaticus ATCC 11883; EC 2.8.3.2; Co_SCACT):

MDKERIRLARLHDKVVSADEAAALIRDGMTVGMSGFTRAGDCKEVPFALARRAATEP LRITLMT GASLGNDIDRVLAEADVIARRLPFQSDGTLRRKINAGEVMFIDQHLSETVEQLRSGQIAP VDVA VVEAVAITEQGGIIPSTSVGNSASFAMLARKVIVEINMNMPLELEGLHDIYFPVQRPYRQ PIPL IAPEQRIGLPYIPIDPEKIAAIVITAKDDSPSNALPPDDETRSIAGHLNDFLLREVRAGK LSPS LQPLQAGIGTIANAVLHGLVESPFRDLKMYSEVLQDSTIELLDAGRLSFASASSVTLTRE VYQR FLSNLDRYRSRLLLRPQEISNHPEILRRLGLITINTALECDIYGNVNSTHVGGTHMMNGI GGSG DFARNAHVSVFVTKSVAKGGEVSSIVPMVAHVDHTEHDVDIIVTEHGLADLRGLAPRERA RTVI ANCADPQYRELLGDYFRRASAHGGQTPHLLEEALSWHVGLRDRGTMRSAQPAQALAA [00218] SEQ ID NO: 62 (Putative Succinyl-CoA:oxalate CoA-transferase (SCOCT) from Cupriavidus oxalaticus ATCC 11883; EC 2.8.3.2; Co_SCMCT):

MVNEANKEKMPLQGVRVLELGSLIAGPYAGGLLAQFGAEVLKIEAPGEGDPLRKWRK LYEGTSL WWYSQSRNKKSLTLDLRSAQGQDIVRKLVAGADIVIENFRPGTLEKWGLGWEDLRKVNPA LVMV RISGYGQTGPYKDRPGFAAIAESMGGLRYVSGYPDRPPVRSGVSIGDTLASLYGVIGALL AMHH LRNNDGEGQFVDVALYESVFAVMESLVPEFDKFGHVRERSGASLPGISPSNTYPCQDGQY VIIA GNGDAIFRRFMTAIGRDDLGQDPRLAHNDGRVQHNAMLDDAIAAWTAAHDLDTVLATLEA AAVP CGRIYTAQDICSDPHYSARGMIEPHQLPDGSPLALSGIVPRLSETPGRTNWIGPALGEHT EEIL AGIGIAGAEFRALREAGVV [00219] SEQ ID NO: 63 (pZR748 - Sc_YBR222C, Sc_YEL020C, Of_oxlT expression vector):

GGAGAGCTGTATGTGGGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTT CGTTTTA CAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAA GTTT CACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTG GATC ACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATATT AACA ATAATTTATTTTCAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTA GCGT ATCCGATAATGTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCT ATCC CACATGGTGGGTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCT GTTT TCAGACAAGATACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCC TCGG TGCTACTATGGACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTT CAAT TTTTATTTGAATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTA CAGA GTTCTGAAATTCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCG ATGC GACCAGGTTTAGGGTAGAGTATGATATATACTCTCCAGAGGACAACTACAAAAGGGTTAT TTAC CGGTCTTTGAACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCC CGTT CCAGTGACGTTGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGC CTTT GTTACATTTGAACATTGTGAGAAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCC CTTG GACAGATCTTATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTT TCCA CTTTTAGAACTCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGG ACCA ATTTGTTAAGTACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCT GAAC CAGCAACGTTCCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGA TGAC CGAAGCATCACATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTAC TGTG GGCCAGCCACAAGGAGTCACCGTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCG GGCA AAGTCGGCGAAGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAA AAGC TAACAAGGAGAACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTT CGAC CCTGAGGGGTTTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAA AAGA TTTCACCCATTGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTG CATT TGGTGTTCCCGACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGG AGAA AAAATGACCTACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATT CCAA CCAAGGTGTACTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAG TTAT CGCAGAAACTTTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGGTTCCTAGCTGAT TAGA AGGCCATCCTGACGGATGGCCTTTTTTTTGACTGGTAAGCCAATCTAGGGCCTCGTCTGT AGGA TAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTT TTTG TTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATA ATGT TCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGGATCACACAACATTTAAAAAAT AACA TTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATATTAACAATAATTTATTTTCAATGA CCAC GACCGCTACCCAACACTTCGCTCAACTTTTACAAAAATATGGCATCGACACAGTCTTTGG AATT GTGGGCATCCCTATTGTCCAACTAGCGGATACGATGGTTGCCAACGGTATCAAATTCATT CCAT GCAGGAACGAACAGGCTGCCTCATATGCAGCCTCTGCTTATGGTTATATTAGTGATAAGC CCGG CGTGTTACTTATTGTCGGGGGCCCCGGTTTAATCCACGCACTGGCTGGTATATACAACTC AATG AGTAATAGGTGGCCTCTTCTAGTAATTGCAGGGAGTTCTTCTCAAAGTGATATACATAAA GGCG GGTTTCAAGAGTTGGATCAAGTTAGTCTTTTGTCCCCATTTTTGAAGTTTACCGGAAAGT TAAC CCCTGACAATATTGACATGATTACTCAGAAGGCTTTGAATTACTGTATACAAGGCACTGC AGGG GTTTCTTACATAGACGTCCCTGCAGATTTTATTGAGTATGAAAAACCCTTAGAAGGAAAC GACC GTACAGGAAATGAATTACCGATGATATTAACTCCAAACATATGTGGCCCTGATCCGTCGA AGAT CAAAAAAGTCGTACAGCTTATTTTGCAACATAAAAATAAAAATATTCTGATTGTTATTGG AAAG GGTGCGGTAAAAAACTCACACGAAATCCGCAGACTAGTAAATACGTTCAATCTACCATTT TTAC CCACCCCAATGGCTAAGGGAATTGTCCCAGACTCTTCTCCACTGAACGTTTCATCTGCAA GATC TCAAGCATTGAAAATAGCGGATATTGTTCTTGTTCTCGGGGCAAGATTAAACTGGATATT GCAT TTTGGTACTTCACCCAAATGGAACTCAGAATCCATATTCATCCAGTTCGATTCCAATCCC GAAA CCTTGGGGGATAACAATGTCTCACCTGGTGCTGACCTTTCCATATGGGGAGATATAGGCT TGAG CGTAACCGCTTTAGTTGAGGAATTGACTCGCCAAGATTCCTGCTGGAAGTATAGTGGTGT TAAG CAAGAAATACGAGAGAAAATTCAACTGAATCAAACTCGTCTATTGAGGAAAGAGAAGACT AGAG GGGCACAATTGAATTACAACCAGGTTTATGGAACATTGAGGCCTCTTATCGATGATTACA GGAC AATACTTGTGACGGAGGGAGCAAATACTATGGATATTGCGCGTATTTCATTCCCTACAGA CGCT CCAAGGCGCCGTTTAGACGCAGGGACCAACGCGACTATGGGGATTGGGCTCGGATATGCT CTTG CATGCAAGGCATCTCATCCGGAACTCGATGTGGTGCTGATTCAGGGTGATTCCGCATTTG GATT CTCTGCCATGGAAATTGAAACGGCAGTAAGGTGTCAGCTGGCATTGGTCATCGTTGTGAT GAAC AATAGCGGTATTTACCATGGAGAAAAGGATATAGAGGGTGATTTACCTCCAACGGCACTA AGCA AGAACTGCCGTTACGATCTCGTAGGCAAAGGACTGGGTGCCAATGATTTTTTTGTCAACA CAAT AAGCGAACTGAGCAGATGCTTCCAACAAGCCGTGCAGCTTTCTCGGACTAAAAGAGAAAC AAGT GTCATCAACGTTATCATTGAGCCTGGCGAACAAAAGCAAATTGCCTTTGCCTGGCAGAAT AAAC CGCGTTTATAGGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGA CTGC GTTCCTGGCGTGGTGCTCGCATAGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGC CTTT CGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAA ATTT AAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAG TAGC CTGGATCACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGG TAAT ATTAACAATAATTTATTTTAATGAATAATCCACAAACAGGACAATCAACAGGCCTCTTGG GCAA TCGTTGGTTCTACTTGGTATTAGCAGTTTTGCTGATGTGTATGATCTCGGGTGTCCAATA TTCC TGGACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTTCTTTGGCTGCGGTTCAG ACGG CTTTCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTG ATAA ATTCGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTTCTCGCTGGCTGGACCTT CATG GGTATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTCTGGCCGGTGCAGGTGTT GGTA TCGTTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCCGGACAAACGCGGTCTGG CTTC CGGTTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTCCTGCCACTGATCAGCTC CGTT CTGAAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTTTGATCATGGGTATCCTG ATTA TCCTGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGCCAAAAAACAAATCGTTG TTAC CGACAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAATTCTGGGTTCTGTGGAC CGCA TTCTTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACAGCGTCCCTTACGGTCGC AGCC TCGGTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCAGAACCTGTTCAATGGTG GTTG CCGTCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTACAAAACCATGTCCGTCGT TTTC GGTATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTGCCTTGGGCGATGTAGCC TTTA TCGCCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTACGCTCTGTTCCCATCGA CCAA CAGCGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGTTTCTTCTGGGCTGCAAA AGCA ACTGCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAACCAACTTCGGATGGAAT ACCG CTTTCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCTGGCTACCTTCGTTATTC CAAG AATGGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAAGAAAAAGCTGTACATTA AGGT TCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTGCTATGACTAAA CGGC GCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGTTTCATCAGCCATCCGCTTGCC CTCA TCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCAGGATTCCCGTTGAGCACCGCC AGGT GCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGGGTGGGCCTACTTCACCTATCC TGCC CGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACGAACCCTTTGGCAAAATCCTGT ATAT CGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATAATGACCCCGAAGCAGGGTTAT GCAG CGGAAAAGCGGGATTAAAAGTCGGGGATTGGTGAACAAAAAGGTGTTTCTCTCTTTAAGA GAAA TATCGTTTTGCTAAACAGTTGATATTGAGGTATCATTTTATCGTAAAAGACATTTTTGCT CAAC AATTGCTTGACGGAAATCAACAAATTTTAGCATTTTGTAAAAAAGTCGCTATATAATTTG GTGA ATTGGAGTTATTTTCATATTTTTGCATCCCGAAGAGTTTCTCTTAAAGAGAGAAACATCT TTTG CATACCTTTTCCGACCGAATTTTTATGTCGTAAAGAGGGGCTTTGCAGGGGGTGGACTCA GAAA GATGAGAATAGATGACTATTGTAGTTGAAACACATAGAAAGTTGCTGATATACAGACCGA TACG CATATCGGGATGAACCATGAGTACGTTCTTTTCTCAAAAAACATAAATATTCGAAAAGAG ATGC AATAAATTAAGGAGAGGTTATAATGAACAAAGTAAATATAAAAGATAGTCAAAATTTTAT TACT TCAAAATATCACATAGAAAAAATAATGAATTGCATAAGTTTAGATGAAAAAGATAACATC TTTG AAATAGGTGCAGGGAAAGGTCATTTTACTGCTGGATTGGTAAAGAGATGTAATTTTGTAA CGGC GATAGAAATTGATTCTAAATTATGTGAGGTAACTCGTAATAAGCTCTTAAATTATCCTAA CTAT CAAATAGTAAATGATGATATACTGAAATTTACATTTCCTAGCCACAATCCATATAAAATA TTTG GCAGCATACCTTACAACATAAGCACAAATATAATTCGAAAAATTGTTTTTGAAAGTTCAG CCAC AATAAGTTATTTAATAGTGGAATATGGTTTTGCTAAAATGTTATTAGATACAAACAGATC ACTA GCATTGCTGTTAATGGCAGAGGTAGATATTTCTATATTAGCAAAAATTCCTAGGTATTAT TTCC ATCCAAAACCTAAAGTGGATAGCACATTAATTGTATTAAAAAGAAAGCCAGCAAAAATGG CATT TAAAGAGAGAAAAAAATATGAAACTTTTGTAATGAAATGGGTTAACAAAGAGTACGAAAA ACTG TTTACAAAAAATCAATTTAATAAAGCTTTAAAACATGCGAGAATATATGATATAAACAAT ATTA GTTTCGAACAATTTGTATCGCTATTTAATAGTTATAAAATATTTAACGGCTAAAAACAAT AGGC CACATGCAACTGTAAATGTTTACGCGGGTACCGACACCGCGGTGGAGGGGAATTACGAGT CATT GGTAACTATCTATGAAACTGTTTGATACTTTTATAGTTGATTAAACTTGTTCATGGCATT TGCC TTAATATCATCCGCTATGTCAATGTAGGGTTTCATAGCTTTGTAGTCGCTGTGTCCCGTC CATT TCATGACCACCTGTGCCGGGATTCCGAGAGCCAGCGCATTGCAGATGAATGTCCTTTTTC CTGC ATGGGTACTGAGCAAAGCGTATTTGGGTGTGACTTCATCAATACGTTCATTTCCCTTGTA GTAG GTTTCCCGTACAGGCTCGTTGATTTCTGCCAGTTCGCCCAGCTCTTTCAGGTAATCGTTC ATCT TCTGGTTGCTGATGACGGGCAGAGCCATGTAATTCTCGAAATGGATGTCCTTGTATTTGT CCAG TATGGCTTTGCTGTATTTGTTCAGTTCAATCGTCAGGCTGTCGGCAGTCTTGACTGTGGT TATT TCGATGTGGTCGGACTTCACATCGCTTCTTTTCAGATTGCGAACATCCGAATACCGCAAA CTCG TAAAGCAGCAGAACAGGAAAACATCACGCACACGTTCCAGGTATTGCTTATCCTTGGGTA TCTG GTAGTCTTTCAGCTTGTTCAGTTCATCCCAAGTCAGGAAGATTACTTTTTTCGAGGTGGT TTTC AGTTTCGGTTTGAACGTATCGTATGCAATGTTCTGATGATGTCCTTTCTTGAAGCTCCAG CGCA GGAACCATTTGAGGAATCCCATTTGCTTGCCGATGGTGCTGTTTCTCATATCCTTGGTGT CACG CAGGAAGTTGACGTATTCGTTCAATCCAAACTCGTTGAAATAGTTGAACGTTGCATCCTC CTTG AACTCTTTGAGGTGGTTCCTCACTGCTGCAAATTTTTCATAGGTGGATGCCGTCCAGTTA TTCT GGTTACCGCACTCTTTTACAAACTCATCGAACACCTCCCAAAAGCTGACAGGGGCTTCTT CCGG CTGTTCTTCACTGGTATCTTTCATTCTCATGTTGAAAGCTTCCTTCAACTGTTGGGTCGT TGGC ATGACCTCCTGCACCTCAAATTCCTTGAAAATATTCTGGATTTCGGCATAGTATTTCAGC AAGT CCGTATTGATTTCGGCTGCACTTTGCTTTAGCTTGTTGGTACATCCGTTCTTTACCCGCT GCTT ATCTGCATCCCATTTGGCTACGTCAATCCGGTAGCCCGTTGTAAACTCGATACGTTGGCT GGCA AAGATGACACGCATACGGATGGGTACGTTCTCTACGATTGGCACACCGTTCTTTTTCCGG CTCT CCAATGCAAAAATGATGTTGCGCTTGATATTCATAATTGGGTGCGTTTGAAATTCTACAC CCAA ATATACACCCAATTATTGAGATAGCAAAAGACATTTAGAAACATTTACTTTTACTCTATA TTGT AATTTACACTTGATTATCAGTCGTTTGCAGTCTTATGATATTCTGTGAAAGTATAAGTTC GAGA GCCTGTCTCTCCGCAAAAAACGCTGAAAATCAGCAGATTGCAAAACAAACACCCTGTTTT ACAC CCAAGAATGTAAAGTCGGGTGTTTTTGTTTTATTTAAGATAATACAACCACTACATAATA AAAG AGTAGCGATATTAAAAGAATCCGATGAGAAAAGACTAATATTTATCTATCCATTCAGTTT GATT TCTCAGGACTTTACATCGTCCTGAAAGTATTTGTTGCCAGTGTTACAACCAATTAACCAA TTCT GATTAGAAAAACTCATCGAGCATCAAATGAAACTGCAATTTATTCATATCAGGATTATCA ATAC CATATTTTTGAAAAAGCCGTTTCTGTAATGAAGGAGAAAACTCACCGAGGCAGTTCCATA GGAT GGCAAGATCCTGGTATCGGTCTGCGATTCCGACTCGTCCAACATCAATACAACCTATTAA TTTC CCCTCGTCAAAAATAAGGTTATCAAGTGAGAAATCACCATGAGTGACGACTGAATCCGGT GAGA ATGGCAAAAGCTTATGCATTTCTTTCCAGACTTGTTCAACAGGCCAGCCATTACGCTCGT CATC AAAATCACTCGCATCAACCAAACCGTTATTCATTCGTGATTGCGCCTGAGCGAGGCGAAA TACG CGATCGCTGTTAAAAGGACAATTACAAACAGGAATCGAATGCAACCGGCGCAGGAACACT GCCA GCGCATCAACAATATTTTCACCTGAATCAGGATATTCTTCTAATACCTGGAATGCTGTTT TCCC GGGGATCGCAGTGGTGAGTAACCATGCATCATCAGGAGTACGGATAAAATGCTTGATGGT CGGA AGAGGCATAAATTCCGTCAGCCAGTTTAGTCTGACCATCTCATCTGTAACATCATTGGCA ACGC TACCTTTGCCATGTTTCAGAAACAACTCTGGCGCATCGGGCTTCCCATACAATCGATAGA TTGT CGCACCTGATTGCCCGACATTATCGCGAGCCCATTTATACCCATATAAATCAGCATCCAT GTTG GAATTTAATCGCGGCCTGGAGCAAGACGTTTCCCGTTGAATATGGCTCATAACACCCCTT GTAT TACTGTTTATGTAAGCAGACAGTTTTATTGTTCATGATGATATATTTTTATCTTGTGCAA TGTA ACATCAGAGATTTTGAGACACAACGTGGCTTTGTTGAATAAATCGAACTTTTGCTGAGTT GAAG GATCAGCCGCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCATGTTTCACGTACT AAGC TCTCATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTCATGGCTAACGTA CTAA GCTCTCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTGAAC AATA AAATTAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAA AAGA ATATATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACAAGCCAGGGATGT AACG CACTGAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGGAACACTTAACGG CTGA CATGGGGCGGCCGCTCAAGTAG [00220] SEQ ID NO: 64 (pZR753- Ec_frc, Of_oxc, Sc_YBR222C, Of_oxlT expression vector):

GGAGAGCTGTATGTGGGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTT CGTTTTA CAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAA GTTT CACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTG GATC ACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATATT AACA ATAATTTATTTTCAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTG TGCA ATCTGGCCCATCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGA ACGT CCCGGCGTTGGTGACGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTT TACT TCACCATGCTTAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCA AAGA GGTAATGGAAAAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGC CATT GATCACATGGGCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGT TCGA TCAAAGGGTTTGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTC AGGC AGCGGGTGGCGCGGCATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGC AGCG TTGGGTGACAGCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCAT CGCG AAAAAACGGGGCGTGGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTT GCCG CGTGAAATTACGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCA GTAT CCGAATGGTACATTTGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAG CCTG GCTGGATCCTGAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTA TTCA GGAGCAAAACTGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCC GGCA TACAGTACAGCCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAA TACA CTGTCACTATTGATAAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTG CACC GGTTTTAAGTATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGT TGAA GTGGAACAACCGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCC TTTA CGCCGGATATTAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGC TGGG TTATAGCGACGATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTAGCT GATT AGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTGGTAAGCCAATCTAGGGCCTCGTC TGTA GGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTT TTTT TTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAA ATAA TGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGAGCTGTCACCGGATGTGCT TTCC GGTCTGATGAGTCCGTGAGGACGAAACAGCCTCTACAAATAATTTTGTTTAATCCATCAA TTTA AAATTTAAAATAATGGTTTTTACTCTGGAAGATTTTGTTGGCGATTGGCGTCAGACCGCG GGTT ATAATTTGGATCAAGTCCTGGAACAGGGTGGCGTAAGCTCTCTGTTCCAGAACCTGGGTG TGAG CGTGACGCCGATTCAGCGCATCGTTCTGTCCGGCGAGAACGGTCTGAAAATTGATATTCA TGTG ATCATCCCGTACGAAGGCCTGAGCGGTGACCAAATGGGTCAAATCGAGAAAATCTTTAAA GTCG TCTACCCAGTTGACGATCACCACTTCAAGGTTATCTTGCATTACGGTACGCTGGTGATTG ATGG TGTGACCCCGAATATGATTGACTATTTCGGCCGTCCGTATGAAGGCATTGCCGTTTTTGA CGGT AAAAAGATCACCGTCACCGGTACCCTGTGGAATGGCAATAAGATTATTGACGAGCGTCTG ATTA ACCCGGACGGCAGCCTGCTGTTCCGCGTGACCATCAACGGTGTCACGGGTTGGCGTCTGT GCGA TTGATCGATGCCCTGAAAATGAATGACATCGATACCATGTATGGTGTTGTCGGCATTCCT ATCA CGAACCTGGCTCGTATGTGGCAAGATGACGGTCAGCGTTTTTACAGCTTCCGTCACGAAC AACA CGCAGGTTATGCAGCTTCTATCGCCGGTTACATCGAAGGAAAACCTGGCGTTTGCTTGAC CGTT TCCGCCCCTGGCTTCCTGAACGGCGTGACTTCCCTGGCTCATGCAACCACCAACTGCTTC CCAA TGATCCTGTTGAGCGGTTCCAGTGAACGTGAAATCGTCGATTTGCAACAGGGCGATTACG AAGA AATGGATCAGATGAATGTTGCACGTCCACACTGCAAAGCTTCTTTCCGTATCAACAGCAT CAAA GACATTCCAATCGGTATCGCTCGTGCAGTTCGCACCGCTGTATCCGGACGTCCAGGTGGT GTTT ACGTTGACTTGCCAGCAAAACTGTTCGGTCAGACCATTTCTGTAGAAGAAGCTAACAAAC TGCT CTTCAAACCAATCGATCCAGCTCCGGCACAGATTCCTGCTGAAGATGCTATCGCTCGCGC TGCT GACCTGATCAAGAACGCCAAACGTCCAGTTATCATGCTGGGTAAAGGCGCTGCATACGCA CAAT GCGACGACGAAATCCGCGCACTGGTTGAAGAAACCGGCATCCCATTCCTGCCAATGGGTA TGGC TAAAGGCCTGCTGCCTGACAACCATCCACAATCCGCTGCTGCAACCCGTGCTTTCGCACT GGCA CAGTGTGACGTTTGCGTACTGATCGGCGCTCGTCTGAACTGGCTGATGCAGCACGGTAAA GGCA AAACCTGGGGCGACGAACTGAAGAAATACGTTCAGATCGACATCCAGGCTAACGAAATGG ACAG CAACCAGCCTATCGCTGCACCAGTTGTTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCG CAAA GCACTGAAAGGCGCTCCAAAAGCTGACGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTT GACG GCAACAAAGCCAAACTGGCTGGCAAGATGACTGCCGAAACCCCATCCGGAATGATGAACT ACTC CAATTCCCTGGGCGTTGTTCGTGACTTCATGCTGGCAAATCCGGATATTTCCCTGGTTAA CGAA GGCGCTAATGCACTCGACAACACTCGTATGATTGTTGACATGCTGAAACCACGCAAACGT CTTG ACTCCGGTACCTGGGGTGTTATGGGTATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTG TTAC CGGCAAACCGGTTATCGCTGTTGAAGGCGATAGCGCATTCGGTTTCTCCGGTATGGAACT GGAA ACCATCTGCCGTTACAACCTGCCAGTTACCGTTATCATCATGAACAATGGTGGTATCTAT AAAG GTAACGAAGCAGATCCACAACCAGGCGTTATCTCCTGTACCCGTCTGACCCGTGGTCGTT ACGA CATGATGATGGAAGCATTTGGCGGTAAAGGTTATGTTGCCAATACTCCAGCAGAACTGAA AGCT GCTCTGGAAGAAGCTGTTGCTTCCGGCAAACCATGCCTGATCAACGCGATGATCGATCCA GACG CTGGTGTCGAATCTGGCCGTATCAAGAGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAAT AAGG TTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTGCGTTCCTGGC GTGG TGCTCGCATAGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACA ATTG GGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCA CTTG AACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGGATCAC ACAA CATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATATTAACAAT AATT TATTTTCAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTAGCGTAT CCGA TAATGTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCTATCCCA CATG GTGGGTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCTGTTTTC AGAC AAGATACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCCTCGGTG CTAC TATGGACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTTCAATTT TTAT TTGAATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTACAGAGT TCTG AAATTCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCGATGCGA CCAG GTTTAGGGTAGAGTATGATATATACTCTCCAGAGGACAACTACAAAAGGGTTATTTACCG GTCT TTGAACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCCCGTTCC AGTG ACGTTGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGCCTTTGT TACA TTTGAACATTGTGAGAAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCCCTTGGA CAGA TCTTATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTTTCCACT TTTA GAACTCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGGACCAAT TTGT TAAGTACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCTGAACAT GCCC AAACCAAACCCTTTCCCACACATTAGATTCATCAGATCGTGTTCTTCTGCTTTGGCTCCA GCAA CGTTCCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGATGACCG AAGC ATCACATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTACTGTGGG CCAG CCACAAGGAGTCACCGTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCGGGCAAA GTCG GCGAAGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAAAAGCTA ACAA GGAGAACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTTCGACCC TGAG GGGTTTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAAAAGATT TCAC CCATTGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTGCATTTG GTGT TCCCGACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGGAGAAAA AATG ACCTACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATTCCAACC AAGG TGTACTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAGTTATCG CAGA AACTTTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGGTTCCTAGCTGATTAGAAG GCCA TCCTGACGGATGGCCTTTTTTTTGACTGCCCGACGAACGGACTAATCCTGACGTAGGATA AAAC GAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTT TTGT TTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTC TTAT ATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGGATCACACAACATTTAAAAAATAACATT ATGA AAGCACTCGAAAAGAGATTCAAAGGTAATATTAACAATAATTTATTTTAATGAATAATCC ACAA ACAGGACAATCAACAGGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAGCAGTTTTG CTGA TGTGTATGATCTCGGGTGTCCAATATTCCTGGACACTGTACGCTAACCCGGTTAAAGACA ACCT TGGCGTTTCTTTGGCTGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATTCAAGCTGG TTCT CAGCCTGGTGGTGGTTACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGATGTTCGGT GGTG CGATGGTTCTCGCTGGCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGCTCTGTATG CTCT TTATACTCTGGCCGGTGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAACACGGCTAA CAGA TGGTTCCCGGACAAACGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACGGTCTGGGT GTTC TGCCGTTCCTGCCACTGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGCAGCATTCA TGTA CACCGGTTTGATCATGGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGTTTCCCTGG CCAG CAAGGCGCCAAAAAACAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCGAAATGCTG AGAA CACCACAATTCTGGGTTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGGTTTGCTGC TGGT TGCCAACAGCGTCCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTGACGATCGG TGTT TCGATCCAGAACCTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTTCCGATAAA ATCG GCCGTTACAAAACCATGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGCACTTTTCC CGAC GATTGCTGCCTTGGGCGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTCTTCACATG GGGT GGTAGCTACGCTCTGTTCCCATCGACCAACAGCGATATTTTCGGTACGGCATACTCTGCC AGAA ACTATGGTTTCTTCTGGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGGTCTGGGTG CTGC AATTGCAACCAACTTCGGATGGAATACCGCTTTCCTGATTACTGCGATTACTTCTTTCAT CGCA TTTGCTCTGGCTACCTTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAATGGTCAAA TTGT CTCCAGAAGAAAAAGCTGTACATTAAGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGA TGGC CTTTTTTTTGACTGCTATGACTAAACGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTT GGCT TGGTTTCATCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTC GCAG AGCAGGATTCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCC GCTC GCGGGTGGGCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAG TCTA CACGAACCCTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAA TCGC TATAATGACCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCGGGGATTGG TGAA CAAAAAGGTGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGATATTGAGGT ATCA TTTTATCGTAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAAATTTTAGC ATTT TGTAAAAAAGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTTGCATCCCG AAGA GTTTCTCTTAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTTTATGTCGT AAAG AGGGGCTTTGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTAGTTGAAAC ACAT AGAAAGTTGCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTACGTTCTTT TCTC AAAAAACATAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAATGAACAAA GTAA ATATAAAAGATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAATAATGAATT GCAT AAGTTTAGATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCATTTTACTGC TGGA TTGGTAAAGAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTATGTGAGGTA ACTC GTAATAAGCTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACTGAAATTTA CATT TCCTAGCCACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGCACAAATAT AATT CGAAAAATTGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAATATGGTTTT GCTA AAATGTTATTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGTAGATATTT CTAT ATTAGCAAAAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGCACATTAAT TGTA TTAAAAAGAAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAACTTTTGTA ATGA AATGGGTTAACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAAAGCTTTAA AACA TGCGAGAATATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTATTTAATAG TTAT AAAATATTTAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTACGCGGGTAC CGAC ACCGCGGTGGAGGGGAATTACGAGTCATTGGTAACTATCTATGAAACTGTTTGATACTTT TATA GTTGATTAAACTTGTTCATGGCATTTGCCTTAATATCATCCGCTATGTCAATGTAGGGTT TCAT AGCTTTGTAGTCGCTGTGTCCCGTCCATTTCATGACCACCTGTGCCGGGATTCCGAGAGC CAGC GCATTGCAGATGAATGTCCTTTTTCCTGCATGGGTACTGAGCAAAGCGTATTTGGGTGTG ACTT CATCAATACGTTCATTTCCCTTGTAGTAGGTTTCCCGTACAGGCTCGTTGATTTCTGCCA GTTC GCCCAGCTCTTTCAGGTAATCGTTCATCTTCTGGTTGCTGATGACGGGCAGAGCCATGTA ATTC TCGAAATGGATGTCCTTGTATTTGTCCAGTATGGCTTTGCTGTATTTGTTCAGTTCAATC GTCA GGCTGTCGGCAGTCTTGACTGTGGTTATTTCGATGTGGTCGGACTTCACATCGCTTCTTT TCAG ATTGCGAACATCCGAATACCGCAAACTCGTAAAGCAGCAGAACAGGAAAACATCACGCAC ACGT TCCAGGTATTGCTTATCCTTGGGTATCTGGTAGTCTTTCAGCTTGTTCAGTTCATCCCAA GTCA GGAAGATTACTTTTTTCGAGGTGGTTTTCAGTTTCGGTTTGAACGTATCGTATGCAATGT TCTG ATGATGTCCTTTCTTGAAGCTCCAGCGCAGGAACCATTTGAGGAATCCCATTTGCTTGCC GATG GTGCTGTTTCTCATATCCTTGGTGTCACGCAGGAAGTTGACGTATTCGTTCAATCCAAAC TCGT TGAAATAGTTGAACGTTGCATCCTCCTTGAACTCTTTGAGGTGGTTCCTCACTGCTGCAA ATTT TTCATAGGTGGATGCCGTCCAGTTATTCTGGTTACCGCACTCTTTTACAAACTCATCGAA CACC TCCCAAAAGCTGACAGGGGCTTCTTCCGGCTGTTCTTCACTGGTATCTTTCATTCTCATG TTGA AAGCTTCCTTCAACTGTTGGGTCGTTGGCATGACCTCCTGCACCTCAAATTCCTTGAAAA TATT CTGGATTTCGGCATAGTATTTCAGCAAGTCCGTATTGATTTCGGCTGCACTTTGCTTTAG CTTG TTGGTACATCCGTTCTTTACCCGCTGCTTATCTGCATCCCATTTGGCTACGTCAATCCGG TAGC CCGTTGTAAACTCGATACGTTGGCTGGCAAAGATGACACGCATACGGATGGGTACGTTCT CTAC GATTGGCACACCGTTCTTTTTCCGGCTCTCCAATGCAAAAATGATGTTGCGCTTGATATT CATA ATTGGGTGCGTTTGAAATTCTACACCCAAATATACACCCAATTATTGAGATAGCAAAAGA CATT TAGAAACATTTACTTTTACTCTATATTGTAATTTACACTTGATTATCAGTCGTTTGCAGT CTTA TGATATTCTGTGAAAGTATAAGTTCGAGAGCCTGTCTCTCCGCAAAAAACGCTGAAAATC AGCA GATTGCAAAACAAACACCCTGTTTTACACCCAAGAATGTAAAGTCGGGTGTTTTTGTTTT ATTT AAGATAATACAACCACTACATAATAAAAGAGTAGCGATATTAAAAGAATCCGATGAGAAA AGAC TAATATTTATCTATCCATTCAGTTTGATTTCTCAGGACTTTACATCGTCCTGAAAGTATT TGTT GCCAGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCATCAAATGAA ACTG CAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTTCTGTAATGA AGGA GAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTGCGATTCCG ACTC GTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATCAAGTGAGA AATC ACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCTTTCCAGAC TTGT TCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAACCGTTATTC ATTC GTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGACAATTACAAACAG GAAT CGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCTGAATCAGG ATAT TCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAACCATGCATCA TCAG GAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCAGTTTAGTC TGAC CATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAACAACTCTGG CGCA TCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTATCGCGAGCC CATT TATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGGAGCAAGACGTTT CCCG TTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAGTTTTATTGT TCAT GATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACAACGTGGCTT TGTT GAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGCCGCGCAGTTCAACCTGTTGATAGT ACGT ACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTAACGTACTAAGCTCTCATGTT TAAC GAACTAAACCCTCATGGCTAACGTACTAAGCTCTCATGGCTAACGTACTAAGCTCTCATG TTTC ACGTACTAAGCTCTCATGTTTGAACAATAAAATTAATATAAATCAGCAACTTAAATAGCC TCTA AGGTTTTAAGTTTTATAAGAAAAAAAAGAATATATAAGGCTTTTAAAGCTTTTAAGGTTT AACG GTTGTGGACAACAAGCCAGGGATGTAACGCACTGAGAAGCCCTTAGAGCCTCTCAAAGCA ATTT TGAGTGACACAGGAACACTTAACGGCTGACATGGGGCGGCCGCTCAAGTAG [00221] SEQ ID NO: 65 (pZR761 - Sc_YBR222C, Sc_YEL020C expression vector):

GGAGAGCTGTATGTGGGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTT CGTTTTA CAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAA GTTT CACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTG GATC ACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATATT AACA ATAATTTATTTTCAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTA GCGT ATCCGATAATGTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCT ATCC CACATGGTGGGTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCT GTTT TCAGACAAGATACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCC TCGG TGCTACTATGGACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTT CAAT TTTTATTTGAATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTA CAGA GTTCTGAAATTCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCG ATGC GACCAGGTTTAGGGTAGAGTATGATATATACTCTCCAGAGGACAACTACAAAAGGGTTAT TTAC CGGTCTTTGAACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCC CGTT CCAGTGACGTTGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGC CTTT GTTACATTTGAACATTGTGAGAAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCC CTTG GACAGATCTTATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTT TCCA CTTTTAGAACTCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGG ACCA ATTTGTTAAGTACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCT GAAC ATGCCCAAACCAAACCCTTTCCCACACATTAGATTCATCAGATCGTGTTCTTCTGCTTTG GCTC CAGCAACGTTCCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGA TGAC CGAAGCATCACATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTAC TGTG GGCCAGCCACAAGGAGTCACCGTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCG GGCA AAGTCGGCGAAGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAA AAGC TAACAAGGAGAACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTT CGAC CCTGAGGGGTTTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAA AAGA TTTCACCCATTGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTG CATT TGGTGTTCCCGACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGG AGAA AAAATGACCTACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATT CCAA CCAAGGTGTACTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAG TTAT CGCAGAAACTTTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGGTTCCTAGCTGAT TAGA AGGCCATCCTGACGGATGGCCTTTTTTTTGACTGGTAAGCCAATCTAGGGCCTCGTCTGT AGGA TAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTT TTTG TTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATA ATGT TCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGGATCACACAACATTTAAAAAAT AACA TTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATATTAACAATAATTTATTTTCAATGA CCAC GACCGCTACCCAACACTTCGCTCAACTTTTACAAAAATATGGCATCGACACAGTCTTTGG AATT GTGGGCATCCCTATTGTCCAACTAGCGGATACGATGGTTGCCAACGGTATCAAATTCATT CCAT GCAGGAACGAACAGGCTGCCTCATATGCAGCCTCTGCTTATGGTTATATTAGTGATAAGC CCGG CGTGTTACTTATTGTCGGGGGCCCCGGTTTAATCCACGCACTGGCTGGTATATACAACTC AATG AGTAATAGGTGGCCTCTTCTAGTAATTGCAGGGAGTTCTTCTCAAAGTGATATACATAAA GGCG GGTTTCAAGAGTTGGATCAAGTTAGTCTTTTGTCCCCATTTTTGAAGTTTACCGGAAAGT TAAC CCCTGACAATATTGACATGATTACTCAGAAGGCTTTGAATTACTGTATACAAGGCACTGC AGGG GTTTCTTACATAGACGTCCCTGCAGATTTTATTGAGTATGAAAAACCCTTAGAAGGAAAC GACC GTACAGGAAATGAATTACCGATGATATTAACTCCAAACATATGTGGCCCTGATCCGTCGA AGAT CAAAAAAGTCGTACAGCTTATTTTGCAACATAAAAATAAAAATATTCTGATTGTTATTGG AAAG GGTGCGGTAAAAAACTCACACGAAATCCGCAGACTAGTAAATACGTTCAATCTACCATTT TTAC CCACCCCAATGGCTAAGGGAATTGTCCCAGACTCTTCTCCACTGAACGTTTCATCTGCAA GATC TCAAGCATTGAAAATAGCGGATATTGTTCTTGTTCTCGGGGCAAGATTAAACTGGATATT GCAT TTTGGTACTTCACCCAAATGGAACTCAGAATCCATATTCATCCAGTTCGATTCCAATCCC GAAA CCTTGGGGGATAACAATGTCTCACCTGGTGCTGACCTTTCCATATGGGGAGATATAGGCT TGAG CGTAACCGCTTTAGTTGAGGAATTGACTCGCCAAGATTCCTGCTGGAAGTATAGTGGTGT TAAG CAAGAAATACGAGAGAAAATTCAACTGAATCAAACTCGTCTATTGAGGAAAGAGAAGACT AGAG GGGCACAATTGAATTACAACCAGGTTTATGGAACATTGAGGCCTCTTATCGATGATTACA GGAC AATACTTGTGACGGAGGGAGCAAATACTATGGATATTGCGCGTATTTCATTCCCTACAGA CGCT CCAAGGCGCCGTTTAGACGCAGGGACCAACGCGACTATGGGGATTGGGCTCGGATATGCT CTTG CATGCAAGGCATCTCATCCGGAACTCGATGTGGTGCTGATTCAGGGTGATTCCGCATTTG GATT CTCTGCCATGGAAATTGAAACGGCAGTAAGGTGTCAGCTGGCATTGGTCATCGTTGTGAT GAAC AATAGCGGTATTTACCATGGAGAAAAGGATATAGAGGGTGATTTACCTCCAACGGCACTA AGCA AGAACTGCCGTTACGATCTCGTAGGCAAAGGACTGGGTGCCAATGATTTTTTTGTCAACA CAAT AAGCGAACTGAGCAGATGCTTCCAACAAGCCGTGCAGCTTTCTCGGACTAAAAGAGAAAC AAGT GTCATCAACGTTATCATTGAGCCTGGCGAACAAAAGCAAATTGCCTTTGCCTGGCAGAAT AAAC CGCGTTTATAGGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGA CTGC GTTCCTGGCGTGGTGCTCGCATAGTAGACTAGAGATCTATGTGAGGATCCTAACTCGAGA TCGA GACTGCTATGACTAAACGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGTT TCAT CAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCAG GATT CCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGGG TGGG CCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACGA ACCC TTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATAA TGAC CCCGAAGCAGGGTTATGCAGCGGAAAAGTTATATACATTCATGTCCATTTATGTAAAAAA TCCT GCTGACCTTGTTTATGTCTTGTCAGTCACCATTTGCAAAACCATATTTGACCCTCAAAGA GGCT GAATTTGATAAGCAACTTGCTACATACTCATAATAAGGAGCTAAATAGAACACGAATGGG AAAT ACTCAAATGCCAAACTAAAGAAGATATTGGCCAAAATAAACGCTATACCGAGAGAGAAAC TTGA TTTTTCAACTTCCTAAAACAGTGTTGTTCAAACATTTCTACTTATTTGTACTTACCAGTT GAAC CTACGTTTCCCTAATAAAATGTCTATGGTAAAAAGTTAAAAAATCCTCCTACTTTTGTTA GATA TATTTTTTTGTGTAATTTTGTAATCGTTATGCGGCAGTAATAATATACATATTAATACGA GTTA GGAATCCTGTAGTTCTCATATGCTACGAGGAGGTATTAAAAGGTGCGTTTCGACAATGCA TCTA TTGTAGTATATTATTGCTTAATCCAAATGAATATTATAAATTTAGGAATTCTTGCTCACA TTGA TGCAGGAAAAACTTCCGTAACCGAGAATCTGCTGTTTGCCAGTGGAGCAACGGAAAAGTG CGGC TGTGTGGATAATGGTGACACCATAACGGACTCTATGGATATAGAGAAACGTAGAGGAATT ACTG TTCGGGCTTCTACGACATCTATTATCTGGAATGGTGTGAAATGCAATATCATTGACACTC CGGG ACACATGGATTTTATTGCGGAAGTGGAGCGGACATTCAAAATGCTTGATGGAGCAGTCCT CATC TTATCCGCAAAGGAAGGCATACAAGCGCAGACAAAGTTGCTGTTCAATACTTTACAGAAG CTGC AAATCCCGACAATTATATTTATCAATAAGATTGACCGAGCCGGTGTGAATTTGGAGCGTT TGTA TCTGGATATAAAAGCAAATCTGTCTCAAGATGTCCTGTTTATGCAAAATGTTGTCGATGG ATCG GTTTATCCGGTTTGCTCCCAAACATATATAAAGGAAGAATACAAAGAATTTGTATGCAAC CATG ACGACAATATATTAGAACGATATTTGGCGGATAGCGAAATTTCACCGGCTGATTATTGGA ATAC GATAATCGCTCTTGTGGCAAAAGCCAAAGTCTATCCGGTGCTACATGGATCAGCAATGTT CAAT ATCGGTATCAATGAGTTGTTGGACGCCATCACTTCTTTTATACTTCCTCCGGCATCGGTT TCAA ACAGACTTTCATCTTATCTTTATAAGATAGAGCATGACCCCAAAGGACATAAAAGAAGTT TTCT AAAAATAATTGACGGAAGTCTGAGACTTCGAGATGTTGTAAGAATCAACGATTCGGAAAA ATTC ATCAAGATTAAAAATCTAAAAACTATCAATCAGGGCAGAGAGATAAATGTTGATGAAGTG GGCG CCAATGATATCGCGATTGTAGAGGATATGGATGATTTTCGAATCGGAAATTATTTAGGTG CTGA ACCTTGTTTGATTCAAGGATTATCGCATCAGCATCCCGCTCTCAAATCCTCCGTCCGGCC AGAC AGGCCCGAAGAGAGAAGCAAGGTGATATCCGCTCTGAATACATTGTGGATTGAAGATCCG TCTT TGTCCTTTTCCATAAACTCATATAGTGATGAATTGGAAATCTCGTTATATGGTTTAACCC AAAA GGAAATCATACAGACATTGCTGGAAGAACGATTTTCCGTAAAGGTCCATTTTGATGAGAT CAAG ACTATATACAAAGAACGACCTGTAAAAAAGGTCAATAAGATTATTCAGATCGAAGTGCCG CCCA ACCCTTATTGGGCCACAATAGGGCTGACTCTTGAACCCTTACCGTTAGGGACAGGGTTGC AAAT CGAAAGTGACATCTCCTATGGTTATCTGAACCATTCTTTTCAAAATGCCGTTTTTGAAGG GATT CGTATGTCTTGCCAATCCGGGTTACATGGATGGGAAGTGACTGATCTGAAAGTAACTTTT ACTC AAGCCGAGTATTATAGCCCGGTAAGTACACCAGCTGATTTCAGACAGCTGACCCCTTATG TCTT TAGGCTGGCCTTGCAACAGTCAGGTGTGGACATTCTCGAACCGATGCTCTATTTTGAGTT GCAG ATACCCCAAGCGGCAAGTTCCAAAGCTATTACAGATTTGCAAAAAATGATGTCTGAGATT GAAG ATATCAGTTGCAATAATGAGTGGTGTCATATTAAAGGGAAAGTTCCATTAAATACAAGTA AAGA CTATGCATCAGAAGTAAGTTCATACACTAAGGGCTTAGGCATTTTTATGGTTAAGCCATG CGGG TATCAAATAACAAAAGGCGGTTATTCTGATAATATCCGCATGAACGAAAAAGATAAACTT TTAT TCATGTTCCAAAAATCAATGTCATCAAAATAACCACGAGTCATTGGTAACTATCTATGAA ACTG TTTGATACTTTTATAGTTGATTAAACTTGTTCATGGCATTTGCCTTAATATCATCCGCTA TGTC AATGTAGGGTTTCATAGCTTTGTAGTCGCTGTGTCCCGTCCATTTCATGACCACCTGTGC CGGG ATTCCGAGAGCCAGCGCATTGCAGATGAATGTCCTTTTTCCTGCATGGGTACTGAGCAAA GCGT ATTTGGGTGTGACTTCATCAATACGTTCATTTCCCTTGTAGTAGGTTTCCCGTACAGGCT CGTT GATTTCTGCCAGTTCGCCCAGCTCTTTCAGGTAATCGTTCATCTTCTGGTTGCTGATGAC GGGC AGAGCCATGTAATTCTCGAAATGGATGTCCTTGTATTTGTCCAGTATGGCTTTGCTGTAT TTGT TCAGTTCAATCGTCAGGCTGTCGGCAGTCTTGACTGTGGTTATTTCGATGTGGTCGGACT TCAC ATCGCTTCTTTTCAGATTGCGAACATCCGAATACCGCAAACTCGTAAAGCAGCAGAACAG GAAA ACATCACGCACACGTTCCAGGTATTGCTTATCCTTGGGTATCTGGTAGTCTTTCAGCTTG TTCA GTTCATCCCAAGTCAGGAAGATTACTTTTTTCGAGGTGGTTTTCAGTTTCGGTTTGAACG TATC GTATGCAATGTTCTGATGATGTCCTTTCTTGAAGCTCCAGCGCAGGAACCATTTGAGGAA TCCC ATTTGCTTGCCGATGGTGCTGTTTCTCATATCCTTGGTGTCACGCAGGAAGTTGACGTAT TCGT TCAATCCAAACTCGTTGAAATAGTTGAACGTTGCATCCTCCTTGAACTCTTTGAGGTGGT TCCT CACTGCTGCAAATTTTTCATAGGTGGATGCCGTCCAGTTATTCTGGTTACCGCACTCTTT TACA AACTCATCGAACACCTCCCAAAAGCTGACAGGGGCTTCTTCCGGCTGTTCTTCACTGGTA TCTT TCATTCTCATGTTGAAAGCTTCCTTCAACTGTTGGGTCGTTGGCATGACCTCCTGCACCT CAAA TTCCTTGAAAATATTCTGGATTTCGGCATAGTATTTCAGCAAGTCCGTATTGATTTCGGC TGCA CTTTGCTTTAGCTTGTTGGTACATCCGTTCTTTACCCGCTGCTTATCTGCATCCCATTTG GCTA CGTCAATCCGGTAGCCCGTTGTAAACTCGATACGTTGGCTGGCAAAGATGACACGCATAC GGAT GGGTACGTTCTCTACGATTGGCACACCGTTCTTTTTCCGGCTCTCCAATGCAAAAATGAT GTTG CGCTTGATATTCATAATTGGGTGCGTTTGAAATTCTACACCCAAATATACACCCAATTAT TGAG ATAGCAAAAGACATTTAGAAACATTTACTTTTACTCTATATTGTAATTTACACTTGATTA TCAG TCGTTTGCAGTCTTATGATATTCTGTGAAAGTATAAGTTCGAGAGCCTGTCTCTCCGCAA AAAA CGCTGAAAATCAGCAGATTGCAAAACAAACACCCTGTTTTACACCCAAGAATGTAAAGTC GGGT GTTTTTGTTTTATTTAAGATAATACAACCACTACATAATAAAAGAGTAGCGATATTAAAA GAAT CCGATGAGAAAAGACTAATATTTATCTATCCATTCAGTTTGATTTCTCAGGACTTTACAT CGTC CTGAAAGTATTTGTTGCCAGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCAT CGAG CATCAAATGAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAG CCGT TTCTGTAATGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTAT CGGT CTGCGATTCCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAA GGTT ATCAAGTGAGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATG CATT TCTTTCCAGACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCA ACCA AACCGTTATTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAG GACA ATTACAAACAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATT TTCA CCTGAATCAGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTG AGTA ACCATGCATCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCG TCAG CCAGTTTAGTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTT CAGA AACAACTCTGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCG ACAT TATCGCGAGCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCC TGGA GCAAGACGTTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGC AGAC AGTTTTATTGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGA GACA CAACGTGGCTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGCCGCGCAGTT CAAC CTGTTGATAGTACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTAACGTA CTAA GCTCTCATGTTTAACGAACTAAACCCTCATGGCTAACGTACTAAGCTCTCATGGCTAACG TACT AAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTGAACAATAAAATTAATATAAATCA GCAA CTTAAATAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAAGAATATATAAGGCTTTTA AAGC TTTTAAGGTTTAACGGTTGTGGACAACAAGCCAGGGATGTAACGCACTGAGAAGCCCTTA GAGC CTCTCAAAGCAATTTTGAGTGACACAGGAACACTTAACGGCTGACATGGGGCGGCCGCTC AAGT AG [00222] SEQ ID NO: 66 (pZR856 - Of_oxlT expression vector):

GATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACC TTTTTTT TGTTTTGTTTGCAATGGTTAATCTATTGTTGAAATTTAAAGTTTCACTTGAACTTTCAAA TAAT GTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGGATCACACAACATTTAAAAA ATAA CATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATATTAACAATAATTTATTTTAATG AATA ATCCACAAACAGGACAATCAACAGGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAG CAGT TTTGCTGATGTGTATGATCTCGGGTGTCCAATATTCCTGGACACTGTACGCTAACCCGGT TAAA GACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATT CAAG CTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGA TGTT CGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGC TCTG TATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAAC ACGG CTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACG GTCT GGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGC AGCA TTCATGTACACCGGTTTGATCATGGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGT TTCC CTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCG AAAT GCTGAGAACACCACAATTCTGGGTTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGG TTTG CTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTG ACGA TCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTT CCGA TAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGC ACTT TTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTC TTCA CATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCAACAGCGATATTTTCGGTACGGCAT ACTC TGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGG TCTG GGTGCTGCAATTGCAACCAACTTCGGATGGAATACCGCTTTCCTGATTACTGCGATTACT TCTT TCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAA TGGT CAAATTGTCTCCAGAAGAAAAAGCTGTACATTAAGGTTCCTAGCTGATTAGAAGGCCATC CTGA CGGATGGCCTTTTTTTTGACTGCTATGACTTGAGACCGGCTATTACGAGCGCTTAAACGG CGCG CCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGTTTCATCAGCCATCCGCTTGCCCTC ATCT GTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCAGGATTCCCGTTGAGCACCGCCAGG TGCG AATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGGGTGGGCCTACTTCACCTATCCTGC CCGG CTGACGCCGTTGGATACACCAAGGAAAGTCTACACGAACCCTTTGGCAAAATCCTGTATA TCGT GCGAAAAAGGATGGATATACCGAAAAAATCGCTATAATGACCCCGAAGCAGGGTTATGCA GCGG AAAAGTTATATACATTCATGTCCATTTATGTAAAAAATCCTGCTGACCTTGTTTATGTCT TGTC AGTCACCATTTGCAAAACCATATTTGACCCTCAAAGAGGCTGAATTTGATAAGCAACTTG CTAC ATACTCATAATAAGGAGCTAAATAGAACACGAATGGGAAATACTCAAATGCCAAACTAAA GAAG ATATTGGCCAAAATAAACGCTATACCGAGAGAGAAACTTGATTTTTCAACTTCCTAAAAC AGTG TTGTTCAAACATTTCTACTTATTTGTACTTACCAGTTGAACCTACGTTTCCCTAATAAAA TGTC TATGGTAAAAAGTTAAAAAATCCTCCTACTTTTGTTAGATATATTTTTTTGTGTAATTTT GTAA TCGTTATGCGGCAGTAATAATATACATATTAATACGAGTTAGGAATCCTGTAGTTCTCAT ATGC TACGAGGAGGTATTAAAAGGTGCGTTTCGACAATGCATCTATTGTAGTATATTATTGCTT AATC CAAATGAATATTATAAATTTAGGAATTCTTGCTCACATTGATGCAGGAAAAACTTCCGTA ACCG AGAATCTGCTGTTTGCCAGTGGAGCAACGGAAAAGTGCGGCTGTGTGGATAATGGTGACA CCAT AACGGACTCTATGGATATAGAGAAACGTAGAGGAATTACTGTTCGGGCTTCTACGACATC TATT ATCTGGAATGGTGTGAAATGCAATATCATTGACACTCCGGGACACATGGATTTTATTGCG GAAG TGGAGCGGACATTCAAAATGCTTGATGGAGCAGTCCTCATCTTATCCGCAAAGGAAGGCA TACA AGCGCAGACAAAGTTGCTGTTCAATACTTTACAGAAGCTGCAAATCCCGACAATTATATT TATC AATAAGATTGACCGAGCCGGTGTGAATTTGGAGCGTTTGTATCTGGATATAAAAGCAAAT CTGT CTCAAGATGTCCTGTTTATGCAAAATGTTGTCGATGGATCGGTTTATCCGGTTTGCTCCC AAAC ATATATAAAGGAAGAATACAAAGAATTTGTATGCAACCATGACGACAATATATTAGAACG ATAT TTGGCGGATAGCGAAATTTCACCGGCTGATTATTGGAATACGATAATCGCTCTTGTGGCA AAAG CCAAAGTCTATCCGGTGCTACATGGATCAGCAATGTTCAATATCGGTATCAATGAGTTGT TGGA CGCCATCACTTCTTTTATACTTCCTCCGGCATCGGTTTCAAACAGACTTTCATCTTATCT TTAT AAGATAGAGCATGACCCCAAAGGACATAAAAGAAGTTTTCTAAAAATAATTGACGGAAGT CTGA GACTTCGAGATGTTGTAAGAATCAACGATTCGGAAAAATTCATCAAGATTAAAAATCTAA AAAC TATCAATCAGGGCAGAGAGATAAATGTTGATGAAGTGGGCGCCAATGATATCGCGATTGT AGAG GATATGGATGATTTTCGAATCGGAAATTATTTAGGTGCTGAACCTTGTTTGATTCAAGGA TTAT CGCATCAGCATCCCGCTCTCAAATCCTCCGTCCGGCCAGACAGGCCCGAAGAGAGAAGCA AGGT GATATCCGCTCTGAATACATTGTGGATTGAAGATCCGTCTTTGTCCTTTTCCATAAACTC ATAT AGTGATGAATTGGAAATCTCGTTATATGGTTTAACCCAAAAGGAAATCATACAGACATTG CTGG AAGAACGATTTTCCGTAAAGGTCCATTTTGATGAGATCAAGACTATATACAAAGAACGAC CTGT AAAAAAGGTCAATAAGATTATTCAGATCGAAGTGCCGCCCAACCCTTATTGGGCCACAAT AGGG CTGACTCTTGAACCCTTACCGTTAGGGACAGGGTTGCAAATCGAAAGTGACATCTCCTAT GGTT ATCTGAACCATTCTTTTCAAAATGCCGTTTTTGAAGGGATTCGTATGTCTTGCCAATCCG GGTT ACATGGATGGGAAGTGACTGATCTGAAAGTAACTTTTACTCAAGCCGAGTATTATAGCCC GGTA AGTACACCAGCTGATTTCAGACAGCTGACCCCTTATGTCTTTAGGCTGGCCTTGCAACAG TCAG GTGTGGACATTCTCGAACCGATGCTCTATTTTGAGTTGCAGATACCCCAAGCGGCAAGTT CCAA AGCTATTACAGATTTGCAAAAAATGATGTCTGAGATTGAAGATATCAGTTGCAATAATGA GTGG TGTCATATTAAAGGGAAAGTTCCATTAAATACAAGTAAAGACTATGCATCAGAAGTAAGT TCAT ACACTAAGGGCTTAGGCATTTTTATGGTTAAGCCATGCGGGTATCAAATAACAAAAGGCG GTTA TTCTGATAATATCCGCATGAACGAAAAAGATAAACTTTTATTCATGTTCCAAAAATCAAT GTCA TCAAAATAACCACGAGTCATTGGTAACTATCTATGAAACTGTTTGATACTTTTATAGTTG ATTA AACTTGTTCATGGCATTTGCCTTAATATCATCCGCTATGTCAATGTAGGGTTTCATAGCT TTGT AGTCGCTGTGTCCCGTCCATTTCATGACCACCTGTGCCGGGATTCCGAGAGCCAGCGCAT TGCA GATGAATGTCCTTTTTCCTGCATGGGTACTGAGCAAAGCGTATTTGGGTGTGACTTCATC AATA CGTTCATTTCCCTTGTAGTAGGTTTCCCGTACAGGCTCGTTGATTTCTGCCAGTTCGCCC AGCT CTTTCAGGTAATCGTTCATCTTCTGGTTGCTGATGACGGGCAGAGCCATGTAATTCTCGA AATG GATGTCCTTGTATTTGTCCAGTATGGCTTTGCTGTATTTGTTCAGTTCAATCGTCAGGCT GTCG GCAGTCTTGACTGTGGTTATTTCGATGTGGTCGGACTTCACATCGCTTCTTTTCAGATTG CGAA CATCCGAATACCGCAAACTCGTAAAGCAGCAGAACAGGAAAACATCACGCACACGTTCCA GGTA TTGCTTATCCTTGGGTATCTGGTAGTCTTTCAGCTTGTTCAGTTCATCCCAAGTCAGGAA GATT ACTTTTTTCGAGGTGGTTTTCAGTTTCGGTTTGAACGTATCGTATGCAATGTTCTGATGA TGTC CTTTCTTGAAGCTCCAGCGCAGGAACCATTTGAGGAATCCCATTTGCTTGCCGATGGTGC TGTT TCTCATATCCTTGGTGTCACGCAGGAAGTTGACGTATTCGTTCAATCCAAACTCGTTGAA ATAG TTGAACGTTGCATCCTCCTTGAACTCTTTGAGGTGGTTCCTCACTGCTGCAAATTTTTCA TAGG TGGATGCCGTCCAGTTATTCTGGTTACCGCACTCTTTTACAAACTCATCGAACACCTCCC AAAA GCTGACAGGGGCTTCTTCCGGCTGTTCTTCACTGGTATCTTTCATTCTCATGTTGAAAGC TTCC TTCAACTGTTGGGTCGTTGGCATGACCTCCTGCACCTCAAATTCCTTGAAAATATTCTGG ATTT CGGCATAGTATTTCAGCAAGTCCGTATTGATTTCGGCTGCACTTTGCTTTAGCTTGTTGG TACA TCCGTTCTTTACCCGCTGCTTATCTGCATCCCATTTGGCTACGTCAATCCGGTAGCCCGT TGTA AACTCGATACGTTGGCTGGCAAAGATGACACGCATACGGATGGGTACGTTCTCTACGATT GGCA CACCGTTCTTTTTCCGGCTCTCCAATGCAAAAATGATGTTGCGCTTGATATTCATAATTG GGTG CGTTTGAAATTCTACACCCAAATATACACCCAATTATTGAGATAGCAAAAGACATTTAGA AACA TTTACTTTTACTCTATATTGTAATTTACACTTGATTATCAGTCGTTTGCAGTCTTATGAT ATTC TGTGAAAGTATAAGTTCGAGAGCCTGTCTCTCCGCAAAAAACGCTGAAAATCAGCAGATT GCAA AACAAACACCCTGTTTTACACCCAAGAATGTAAAGTCGGGTGTTTTTGTTTTATTTAAGA TAAT ACAACCACTACATAATAAAAGAGTAGCGATATTAAAAGAATCCGATGAGAAAAGACTAAT ATTT ATCTATCCATTCAGTTTGATTTCTCAGGACTTTACATCGTCCTGAAAGTATTTGTTGCCA GTGT TACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCATCAAATGAAACTGCAAT TTAT TCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTTCTGTAATGAAGGAGAAA ACTC ACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTGCGATTCCGACTCGTCC AACA TCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATCAAGTGAGAAATCACCA TGAG TGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCTTTCCAGACTTGTTCAA CAGG CCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAACCGTTATTCATTCGTGA TTGC GCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGACAATTACAAACAGGAATCGAA TGCA ACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCTGAATCAGGATATTCTT CTAA TACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAACCATGCATCATCAGGAGT ACGG ATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCAGTTTAGTCTGACCATC TCAT CTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAACAACTCTGGCGCATCGG GCTT CCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTATCGCGAGCCCATTTATA CCCA TATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGGAGCAAGACGTTTCCCGTTGA ATAT GGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAGTTTTATTGTTCATGATG ATAT ATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACAACGTGGCTTTGTTGAAT AAAT CGAACTTTTGCTGAGTTGAAGGATCAGCCGCGCAGTTCAACCTGTTGATAGTACGTACTA AGCT CTCATGTTTCACGTACTAAGCTCTCATGTTTAACGTACTAAGCTCTCATGTTTAACGAAC TAAA CCCTCATGGCTAACGTACTAAGCTCTCATGGCTAACGTACTAAGCTCTCATGTTTCACGT ACTA AGCTCTCATGTTTGAACAATAAAATTAATATAAATCAGCAACTTAAATAGCCTCTAAGGT TTTA AGTTTTATAAGAAAAAAAAGAATATATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTG TGGA CAACAAGCCAGGGATGTAACGCACTGAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAG TGAC ACAGGAACACTTAACGGCTGACATGGGGCGGCCGCTCAACGTACCGGTCTCAGTAGGGAG AGCT GTATGTGGGTAG [00223] SEQ ID NO: 67 (pZR878 - Ec_frc, Of_oxc, Sc_YBR222C, Sc_YEL020C, At_AAE3, Ec_yfdE expression vector):

GGAGAGCTGTATGTGGGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTT CGTTTTA CAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAA GTTT CACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTG GATC ACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATATT AACA ATAATTTATTTTCAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTG TGCA ATCTGGCCCATCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGA ACGT CCCGGCGTTGGTGACGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTT TACT TCACCATGCTTAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCA AAGA GGTAATGGAAAAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGC CATT GATCACATGGGCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGT TCGA TCAAAGGGTTTGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTC AGGC AGCGGGTGGCGCGGCATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGC AGCG TTGGGTGACAGCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCAT CGCG AAAAAACGGGGCGTGGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTT GCCG CGTGAAATTACGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCA GTAT CCGAATGGTACATTTGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAG CCTG GCTGGATCCTGAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTA TTCA GGAGCAAAACTGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCC GGCA TACAGTACAGCCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAA TACA GGTTTTAAGTATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGT TGAA GTGGAACAACCGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCC TTTA CGCCGGATATTAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGC TGGG TTATAGCGACGATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTAGCT GATT AGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTGGTAAGCCAATCTAGGGCCTCGTC TGTA GGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTT TTTT TTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAA ATAA TGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGAGCTGTCACCGGATGTGCT TTCC GGTCTGATGAGTCCGTGAGGACGAAACAGCCTCTACAAATAATTTTGTTTAATCCATCAA TTTA AAATTTAAAATAATGGTTTTTACTCTGGAAGATTTTGTTGGCGATTGGCGTCAGACCGCG GGTT ATAATTTGGATCAAGTCCTGGAACAGGGTGGCGTAAGCTCTCTGTTCCAGAACCTGGGTG TGAG CGTGACGCCGATTCAGCGCATCGTTCTGTCCGGCGAGAACGGTCTGAAAATTGATATTCA TGTG ATCATCCCGTACGAAGGCCTGAGCGGTGACCAAATGGGTCAAATCGAGAAAATCTTTAAA GTCG TCTACCCAGTTGACGATCACCACTTCAAGGTTATCTTGCATTACGGTACGCTGGTGATTG ATGG TGTGACCCCGAATATGATTGACTATTTCGGCCGTCCGTATGAAGGCATTGCCGTTTTTGA CGGT AAAAAGATCACCGTCACCGGTACCCTGTGGAATGGCAATAAGATTATTGACGAGCGTCTG ATTA ACCCGGACGGCAGCCTGCTGTTCCGCGTGACCATCAACGGTGTCACGGGTTGGCGTCTGT GCGA GCGCATCCTGGCAGGTTCAATGAGTAACGACGACAATGTAGAGTTGACTGATGGCTTTCA TGTT TTGATCGATGCCCTGAAAATGAATGACATCGATACCATGTATGGTGTTGTCGGCATTCCT ATCA CGAACCTGGCTCGTATGTGGCAAGATGACGGTCAGCGTTTTTACAGCTTCCGTCACGAAC AACA CGCAGGTTATGCAGCTTCTATCGCCGGTTACATCGAAGGAAAACCTGGCGTTTGCTTGAC CGTT TCCGCCCCTGGCTTCCTGAACGGCGTGACTTCCCTGGCTCATGCAACCACCAACTGCTTC CCAA TGATCCTGTTGAGCGGTTCCAGTGAACGTGAAATCGTCGATTTGCAACAGGGCGATTACG AAGA AATGGATCAGATGAATGTTGCACGTCCACACTGCAAAGCTTCTTTCCGTATCAACAGCAT CAAA GACATTCCAATCGGTATCGCTCGTGCAGTTCGCACCGCTGTATCCGGACGTCCAGGTGGT GTTT ACGTTGACTTGCCAGCAAAACTGTTCGGTCAGACCATTTCTGTAGAAGAAGCTAACAAAC TGCT CTTCAAACCAATCGATCCAGCTCCGGCACAGATTCCTGCTGAAGATGCTATCGCTCGCGC TGCT GACCTGATCAAGAACGCCAAACGTCCAGTTATCATGCTGGGTAAAGGCGCTGCATACGCA CAAT GCGACGACGAAATCCGCGCACTGGTTGAAGAAACCGGCATCCCATTCCTGCCAATGGGTA TGGC TAAAGGCCTGCTGCCTGACAACCATCCACAATCCGCTGCTGCAACCCGTGCTTTCGCACT GGCA CAGTGTGACGTTTGCGTACTGATCGGCGCTCGTCTGAACTGGCTGATGCAGCACGGTAAA GGCA AAACCTGGGGCGACGAACTGAAGAAATACGTTCAGATCGACATCCAGGCTAACGAAATGG ACAG CAACCAGCCTATCGCTGCACCAGTTGTTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCG CAAA GCACTGAAAGGCGCTCCAAAAGCTGACGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTT GACG GCAACAAAGCCAAACTGGCTGGCAAGATGACTGCCGAAACCCCATCCGGAATGATGAACT ACTC CAATTCCCTGGGCGTTGTTCGTGACTTCATGCTGGCAAATCCGGATATTTCCCTGGTTAA CGAA GGCGCTAATGCACTCGACAACACTCGTATGATTGTTGACATGCTGAAACCACGCAAACGT CTTG ACTCCGGTACCTGGGGTGTTATGGGTATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTG TTAC CGGCAAACCGGTTATCGCTGTTGAAGGCGATAGCGCATTCGGTTTCTCCGGTATGGAACT GGAA ACCATCTGCCGTTACAACCTGCCAGTTACCGTTATCATCATGAACAATGGTGGTATCTAT AAAG GTAACGAAGCAGATCCACAACCAGGCGTTATCTCCTGTACCCGTCTGACCCGTGGTCGTT ACGA CATGATGATGGAAGCATTTGGCGGTAAAGGTTATGTTGCCAATACTCCAGCAGAACTGAA AGCT GCTCTGGAAGAAGCTGTTGCTTCCGGCAAACCATGCCTGATCAACGCGATGATCGATCCA GACG CTGGTGTCGAATCTGGCCGTATCAAGAGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAAT AAGG TTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTGCGTTCCTGGC GTGG TGCTCGCATAGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACA ATTG GGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCA CTTG AACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGGATCAC ACAA CATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATATTAACAAT AATT TATTTTCAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTAGCGTAT CCGA TAATGTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCTATCCCA CATG GTGGGTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCTGTTTTC AGAC AAGATACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCCTCGGTG CTAC TATGGACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTTCAATTT TTAT TTGAATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTACAGAGT TCTG AAATTCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCGATGCGA CCAG GTTTAGGGTAGAGTATGATATATACTCTCCAGAGGACAACTACAAAAGGGTTATTTACCG GTCT TTGAACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCCCGTTCC AGTG ACGTTGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGCCTTTGT TACA TTTGAACATTGTGAGAAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCCCTTGGA CAGA TCTTATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTTTCCACT TTTA GAACTCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGGACCAAT TTGT TAAGTACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCTGAACAT GCCC AAACCAAACCCTTTCCCACACATTAGATTCATCAGATCGTGTTCTTCTGCTTTGGCTCCA GCAA CGTTCCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGATGACCG AAGC ATCACATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTACTGTGGG CCAG CCACAAGGAGTCACCGTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCGGGCAAA GTCG GCGAAGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAAAAGCTA ACAA GGAGAACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTTCGACCC TGAG GGGTTTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAAAAGATT TCAC CCATTGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTGCATTTG GTGT TCCCGACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGGAGAAAA AATG ACCTACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATTCCAACC AAGG TGTACTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAGTTATCG CAGA AACTTTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGGTTCCTAGCTGATTAGAAG GCCA TCCTGACGGATGGCCTTTTTTTTGACTGCCCGACGAACGGACTAATCCTGACGTAGGATA AAAC GAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTT TTGT TTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTC TTAT ATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGGATCACACAACATTTAAAAAATAACATT ATGA AAGCACTCGAAAAGAGATTCAAAGGTAATATTAACAATAATTTATTTTCAATGACCACGA CCGC TACCCAACACTTCGCTCAACTTTTACAAAAATATGGCATCGACACAGTCTTTGGAATTGT GGGC ATCCCTATTGTCCAACTAGCGGATACGATGGTTGCCAACGGTATCAAATTCATTCCATGC AGGA ACGAACAGGCTGCCTCATATGCAGCCTCTGCTTATGGTTATATTAGTGATAAGCCCGGCG TGTT ACTTATTGTCGGGGGCCCCGGTTTAATCCACGCACTGGCTGGTATATACAACTCAATGAG TAAT AGGTGGCCTCTTCTAGTAATTGCAGGGAGTTCTTCTCAAAGTGATATACATAAAGGCGGG TTTC AAGAGTTGGATCAAGTTAGTCTTTTGTCCCCATTTTTGAAGTTTACCGGAAAGTTAACCC CTGA CAATATTGACATGATTACTCAGAAGGCTTTGAATTACTGTATACAAGGCACTGCAGGGGT TTCT TACATAGACGTCCCTGCAGATTTTATTGAGTATGAAAAACCCTTAGAAGGAAACGACCGT ACAG GAAATGAATTACCGATGATATTAACTCCAAACATATGTGGCCCTGATCCGTCGAAGATCA AAAA AGTCGTACAGCTTATTTTGCAACATAAAAATAAAAATATTCTGATTGTTATTGGAAAGGG TGCG GTAAAAAACTCACACGAAATCCGCAGACTAGTAAATACGTTCAATCTACCATTTTTACCC ACCC CAATGGCTAAGGGAATTGTCCCAGACTCTTCTCCACTGAACGTTTCATCTGCAAGATCTC AAGC ATTGAAAATAGCGGATATTGTTCTTGTTCTCGGGGCAAGATTAAACTGGATATTGCATTT TGGT ACTTCACCCAAATGGAACTCAGAATCCATATTCATCCAGTTCGATTCCAATCCCGAAACC TTGG GGGATAACAATGTCTCACCTGGTGCTGACCTTTCCATATGGGGAGATATAGGCTTGAGCG TAAC CGCTTTAGTTGAGGAATTGACTCGCCAAGATTCCTGCTGGAAGTATAGTGGTGTTAAGCA AGAA ATACGAGAGAAAATTCAACTGAATCAAACTCGTCTATTGAGGAAAGAGAAGACTAGAGGG GCAC AATTGAATTACAACCAGGTTTATGGAACATTGAGGCCTCTTATCGATGATTACAGGACAA TACT TGTGACGGAGGGAGCAAATACTATGGATATTGCGCGTATTTCATTCCCTACAGACGCTCC AAGG CGCCGTTTAGACGCAGGGACCAACGCGACTATGGGGATTGGGCTCGGATATGCTCTTGCA TGCA AGGCATCTCATCCGGAACTCGATGTGGTGCTGATTCAGGGTGATTCCGCATTTGGATTCT CTGC CATGGAAATTGAAACGGCAGTAAGGTGTCAGCTGGCATTGGTCATCGTTGTGATGAACAA TAGC GGTATTTACCATGGAGAAAAGGATATAGAGGGTGATTTACCTCCAACGGCACTAAGCAAG AACT GCCGTTACGATCTCGTAGGCAAAGGACTGGGTGCCAATGATTTTTTTGTCAACACAATAA GCGA ACTGAGCAGATGCTTCCAACAAGCCGTGCAGCTTTCTCGGACTAAAAGAGAAACAAGTGT CATC AACGTTATCATTGAGCCTGGCGAACAAAAGCAAATTGCCTTTGCCTGGCAGAATAAACCG CGTT TATAGGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTGCTC TGGG TCTGACGGCCATCAAGGGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCG TTTT ACAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAA AGTT TCACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCT GGAT CACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATAT TAAC AATAATTTATTTTCAATGGATAGCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAA AAAT TCCCCGATCGCCGAGCTCTCTCCGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTC ACGA TCTAATCGAACGCGCCGCTTCACGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGT CGTT GCTCTCACCTTCCCTAACACCGTCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCT AGAG CCACGGCGGCGCCGTTGAACGCAGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCG ATTC AGATTCAAAGCTATTGTTAACCTCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTC AAAG CTGAAAATCTCTCACGTCACCGCTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCC GTTG CGGATTCAGATTCCGTCGTTGACTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTG CTCT CTTCCTCCACACTTCTGGCACTACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAA TCTA GCTTCATCCGTCAAGAACATTAAAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTG ATTG TTCTCCCTCTGTTCCATGTTCATGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTG GTGC TGCTGTAACTCTTCCAGCTGCTGGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAA GAAG TATAACGCTACATGGTATACTGCTGTGCCGACCATTCATCAGATCATATTGGACCGCCAC GCGA GCCACCCTGAAACGGAATATCCTAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGG CTCC GGTGATATTGTCCAGGCTTGAGGAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAAT GACA GAGGCAACACATTTGATGAGCTCAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGG TCTG TTGGGAAACCGGTAGGTCAAGAAATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGC CAAA TAACAAAGGAGAGGTTTGTATAAGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCC AGAA GCCAACAAGGCAGGTTTCGAGTTTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGAT ACCG ATGGGTATTTGCATCTGGTGGGTCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGA TATC TCCAATTGAAGTGGATGCAGTACTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATT CGGT GTTCCTGATGAGAAATATGGGGAAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACT ACTG TAACCGAAGAGGACATTAAAGCGTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAA AGAG AGTGTTCATCACTGATAACCTCCCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGT CGCA CAACATTTCCTTGAGAAGCCCTGAGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATG GCCT TTTTTTTGACTGGGTGTTCCGATACACTCAATTTGTGTAGGATAAAACGAAAGGCTCAGT CGAA AGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTA ATCT ATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTC GAAA GAAACAAAGTAGCCTGGATCACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAA AGAG ATTCAAAGGTAATATTAACAATAATTTATTTTCAATGACAAATAATGAAAGCAAAGGGCC GTTT GAAGGCTTATTAGTTATCGATATGACACATGTCCTTAATGGACCTTTCGGAACTCAACTT CTTT GTAATATGGGCGCAAGGGTAATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACCCGCA CATT TGGTCCCTATGTGGATGGACAGTCACTCTATTACAGTTTTATTAATCATGGCAAAGAGAG TGTG GTTCTTGATTTAAAGAATGATCACGATAAAAGTATATTTATAAATATGCTCAAACAAGCT GATG TATTAGCTGAGAATTTTCGCCCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAAACGC TTCA AGAAATCAACCCGCGCCTCATATATGCTTCATCGTCAGGTTTCGGACATACCGGTCCGCT AAAA GATGCTCCTGCCTACGATACCATCATTCAGGCAATGAGCGGGATAATGATGGAAACAGGA TATC CTGATGCTCCGCCAGTGCGCGTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTCTATT TATT CAGCGGAATAGTGAGTGCACTTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATGTCGA TATA GCGATGTTTGATGCCACGCTGAGTTTTCTGGAGCATGGTCTGATGGCATATATCGCAACT GGGA AGTCACCACAACGTCTGGGAAATCGCCATCCCTACATGGCACCTTTTGATGTTTTCAATA CTCA GGATAAGCCGATTACGATTTGTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCCAGGC ACTG GAGCTTACGGAACTGGTTAATGATCCCCGATTTAGCAGCAATATTTTACGCGTACAAAAC CAGG CTATTCTTAAACAATATATTGAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGGTTAG CCAG AATACATGAAGTTGGTGTACCCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTAAATT GCCA CAAACTCAGGCGAGAAATATGTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAATCCG ATAA AAATCAGCGGCTGCGCGGACCCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAGCATG GGGA ACAAATTCGCCAGGAGTTCTCATCATAAGGTTCCTAGCTGATTAGAAGGCCATCCTGACG GATG GCCTTTTTTTTGACTTAGTTTCAATTTTACATTCCAGGAAGTAGACTAGAGATCTATGTG AGGA TCCTAACTCGAGATCGAGACTGCTATGACTAAACGGCGCGCCTGATAGGTGGGCTGCCCT TCCT GGTTGGCTTGGTTTCATCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGG CCAG CCTCGCAGAGCAGGATTCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAG GAAC ACCCGCTCGCGGGTGGGCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACC AAGG AAAGTCTACACGAACCCTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATAC CGAA AAAATCGCTATAATGACCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCG GGGA TTGGTGAACAAAAAGGTGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGAT ATTG AGGTATCATTTTATCGTAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAA ATTT TAGCATTTTGTAAAAAAGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTT GCAT CCCGAAGAGTTTCTCTTAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTT TATG TCGTAAAGAGGGGCTTTGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTA GTTG AAACACATAGAAAGTTGCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTA CGTT CTTTTCTCAAAAAACATAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAA TGAA CAAAGTAAATATAAAAGATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAAT AATG AATTGCATAAGTTTAGATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCAT TTTA CTGCTGGATTGGTAAAGAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTAT GTGA GGTAACTCGTAATAAGCTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACT GAAA TTTACATTTCCTAGCCACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGC ACAA ATATAATTCGAAAAATTGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAAT ATGG TTTTGCTAAAATGTTATTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGT AGAT ATTTCTATATTAGCAAAAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGC ACAT TAATTGTATTAAAAAGAAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAA CTTT TGTAATGAAATGGGTTAACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAA AGCT TTAAAACATGCGAGAATATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTA TTTA ATAGTTATAAAATATTTAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTAC GCGG GTACCGACACCGCGGTGGAGGGGAATTACGAGTCATTGGTAACTATCTATGAAACTGTTT GATA CTTTTATAGTTGATTAAACTTGTTCATGGCATTTGCCTTAATATCATCCGCTATGTCAAT GTAG GGTTTCATAGCTTTGTAGTCGCTGTGTCCCGTCCATTTCATGACCACCTGTGCCGGGATT CCGA GAGCCAGCGCATTGCAGATGAATGTCCTTTTTCCTGCATGGGTACTGAGCAAAGCGTATT TGGG TGTGACTTCATCAATACGTTCATTTCCCTTGTAGTAGGTTTCCCGTACAGGCTCGTTGAT TTCT GCCAGTTCGCCCAGCTCTTTCAGGTAATCGTTCATCTTCTGGTTGCTGATGACGGGCAGA GCCA TGTAATTCTCGAAATGGATGTCCTTGTATTTGTCCAGTATGGCTTTGCTGTATTTGTTCA GTTC AATCGTCAGGCTGTCGGCAGTCTTGACTGTGGTTATTTCGATGTGGTCGGACTTCACATC GCTT CTTTTCAGATTGCGAACATCCGAATACCGCAAACTCGTAAAGCAGCAGAACAGGAAAACA TCAC GCACACGTTCCAGGTATTGCTTATCCTTGGGTATCTGGTAGTCTTTCAGCTTGTTCAGTT CATC CCAAGTCAGGAAGATTACTTTTTTCGAGGTGGTTTTCAGTTTCGGTTTGAACGTATCGTA TGCA ATGTTCTGATGATGTCCTTTCTTGAAGCTCCAGCGCAGGAACCATTTGAGGAATCCCATT TGCT TGCCGATGGTGCTGTTTCTCATATCCTTGGTGTCACGCAGGAAGTTGACGTATTCGTTCA ATCC AAACTCGTTGAAATAGTTGAACGTTGCATCCTCCTTGAACTCTTTGAGGTGGTTCCTCAC TGCT GCAAATTTTTCATAGGTGGATGCCGTCCAGTTATTCTGGTTACCGCACTCTTTTACAAAC TCAT CGAACACCTCCCAAAAGCTGACAGGGGCTTCTTCCGGCTGTTCTTCACTGGTATCTTTCA TTCT CATGTTGAAAGCTTCCTTCAACTGTTGGGTCGTTGGCATGACCTCCTGCACCTCAAATTC CTTG AAAATATTCTGGATTTCGGCATAGTATTTCAGCAAGTCCGTATTGATTTCGGCTGCACTT TGCT TTAGCTTGTTGGTACATCCGTTCTTTACCCGCTGCTTATCTGCATCCCATTTGGCTACGT CAAT CCGGTAGCCCGTTGTAAACTCGATACGTTGGCTGGCAAAGATGACACGCATACGGATGGG TACG TTCTCTACGATTGGCACACCGTTCTTTTTCCGGCTCTCCAATGCAAAAATGATGTTGCGC TTGA TATTCATAATTGGGTGCGTTTGAAATTCTACACCCAAATATACACCCAATTATTGAGATA GCAA AAGACATTTAGAAACATTTACTTTTACTCTATATTGTAATTTACACTTGATTATCAGTCG TTTG CAGTCTTATGATATTCTGTGAAAGTATAAGTTCGAGAGCCTGTCTCTCCGCAAAAAACGC TGAA AATCAGCAGATTGCAAAACAAACACCCTGTTTTACACCCAAGAATGTAAAGTCGGGTGTT TTTG TTTTATTTAAGATAATACAACCACTACATAATAAAAGAGTAGCGATATTAAAAGAATCCG ATGA GAAAAGACTAATATTTATCTATCCATTCAGTTTGATTTCTCAGGACTTTACATCGTCCTG AAAG TATTTGTTGCCAGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCAT CAAA TGAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTTC TGTA ATGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTG CGAT TCCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATC AAGT GAGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCT TTCC AGACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAAC CGTT ATTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGACAATT ACAA ACAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCT GAAT CAGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAACC ATGC ATCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCA GTTT AGTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAAC AACT CTGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTAT CGCG AGCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGGAGCA AGAC GTTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAGT TTTA TTGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACAA CGTG GCTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGCCGCGCAGTTCAACCTG TTGA TAGTACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTAACGTACTAAGCT CTCA TGTTTAACGAACTAAACCCTCATGGCTAACGTACTAAGCTCTCATGGCTAACGTACTAAG CTCT CATGTTTCACGTACTAAGCTCTCATGTTTGAACAATAAAATTAATATAAATCAGCAACTT AAAT AGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAAGAATATATAAGGCTTTTAAAGCTTT TAAG GTTTAACGGTTGTGGACAACAAGCCAGGGATGTAACGCACTGAGAAGCCCTTAGAGCCTC TCAA AGCAATTTTGAGTGACACAGGAACACTTAACGGCTGACATGGGGCGGCCGCTCAAGTAG [00224] SEQ ID NO: 68 (P_BfP1E6):

GATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACC TTTTTTT TGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAA TAAT GTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAG [00225] SEQ ID NO: 69 (P_BfP4E5):

GATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACC TTTTTTT TGTTTTGTTTGCAATGGTTAATCTATTGTTGAAATTTAAAGTTTCACTTGAACTTTCAAA TAAT GTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAG [00226] SEQ ID NO: 70 (Phage promoter consensus):

GTTAA(n) _4-7 GTTAA(n) _34-38 TA(n) ₂ TTTG [00227] SEQ ID NO: 71 (Phage promoter consensus):

GTTAAnnnnnnnGTTAAnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnTAn nTTTG [00228] SEQ ID NO: 72 (NB001 porphyran PUL):

TAAGGATTGATTCGCTAGCTCAGCAGGTAGAGCACAACACTTTTAATGTTGGGGTCC TGGGTTC GAGCCCCAGGCGGATCACTGAAACAAAAAGCAAAACAATGAAAACCGCTGATAATCAATC ATTA TCAGCGGTTTTTCTTTTTATCCATACTGCAAATTGAAGCAGAATACCGCATTTTACTGGA GGTG AAATAGGTGGACTTAATTTCCACATAAAAACAAGTCCACCTGATTGGATTATATTTCACT GATT CTCTGCGTTTTGCATAAAACAAACTCTTTTCAAAACATGTATTTTTACACCATCAAAAAA AGAA GAGTATGGCAATGCAAAGAAACTATTTTACGGTATTGTTTTTCCTGAAGAAATCAAAGCT GCTT AAAAATGGAGAAGCACCAATCTGTATGCGTATCACAATAAACGGAAAACGTGCAGAGGTA CAAA TCAAGCGAAGTATAGATGTTACAAAATGGAATACGCAAAAAGAATGCGCGATTGGCAGGG AAAA GAAGTATCAAGAAATAAACCACTATCTTGATACGATAAGAACTAAAATCCTTCAAATTCA CCGT GAACTTGAGCAGGACGGTAAACCTATTACAGCAGATATTATAAAAAATATCTATTATGGA GAAC ACTCTACTCCCAAAATGCTGCTTGAAGTATTCCAGGAACACAATTCGGAATATCGGGAAT TAAT GAACAAGGAATATGCCGAAGGTACTGTACTTCGATACGAACGTACAGCAAGATATTTGAA GGAG TTTATCAGTGAACAATATAAACTGGCTGATATTCCATTAAAATCAATCAACTATGAATTT ATAA CCAAATTCGAACATTTCATTAAAATACAGAAAAACTGTGCGCAAAATGCGACAGTGAAAT ATCT GAAAAATTTAAAGAAAATCATCAAAACTGCATTGATAAAGAAGTGGATAACTGATGATCC GTTT GCAGAAATACACTTCAAACAGACCAAGTGTAACCGTGAATTCTTAAACGAAATGGAACTT CGCA AAATCATCAATAAAGATTTTGATATTCAACGATTACAAACCGTAAGGGACATATTCATCT TCTG TTGTTTCACCGGTTTGGCTTTCACAGACGTAAAGAATCTGAAAAAGGAACACCTTGTACA GGCT GATAATGGTGAATGGTGGATAAGAAAAGCAAGGGAAAAGACCGATAATATGTGCGACATT CCAT TGTTGGATATACCAAGACTTATTTTAGAGAAATATCAGTCAAATCCAATCTGCAATGAAA AAGG ATTATTACTTCCTGTTCCCAGCAACCAACGAATGAACAGTTATTTGAAAGAAATAGCTGA TGTA TGTGGTATTCAGAAGAATCTTTCCACACATATTGCAAGACATACATTTGCATCACTGGCT ATTG CAAATAAGGTTTCCTTGGAATCCATTGCCAAAATGTTAGGACACACGGACATTCGTACAA CTCG TATTTATGCCAAAATAATGAATTCTACCATTGCCAATGAAATGAAAGTACTGCAAAACAA GTTC GCAATATAATTTTCAACCATTATTTCATTTCTTACAGCAAATATCGCACTTTGCCACTGA CTGT GCAAGGCGGCCCTGTCGGGCTGGTTGGCGGAAAAAAATCATCCTCGCTTCGCTCCGGTAT TTTT TTCCGCCAAGCCTTGCACCGGTCATTGGCAAAGAACAGCCGGGCCAGTAAGAAATTGAAA TACT GGCTCCACGGAGCCGGTCATGTCTAATTTAAATAAAAGAATATGACTGAAGAAGTTGGAA AGAA GGTATGTGAAGGTACAGTAGCAGACCTCATGAAGGACAAGACCGGAAAACAGACGGTTGT CACG TTGACAAGAAAGAATGCTTACCGAGTGAAGAAAATCAGAGAACAAGGGACGGATGACGAA GCTG TCCTTTTTCATTTCCGTGAACGCTGTACGGGAATGGGCTCCTATGTACACACAATCGAAG CGGC AGACGGAGAAACAGAACTTCATCCGTCTGAATTTGAAAAATGGGAAGCTGTGGAATTCCT GTAT CCCGGCTATCTGGAAGACCTGCTTGATGCTGCATACAACGCATACAGATGGAGTTCCTTC GAAC CTGAAGCAAGGGCGGAAACAGACATCATGCAATATGAAAAACAACTTGTAGAGGATCTGA AACA GATTCCGGAAGAAAAACAGAACGAGTATACCAGTGCATACCATAGCAAGTTCTCTGCCTT GCTG GGCTGTCTCTCACGATGTGCCAGTCCGATGGTGACAGGGCCTGCCAAATTCAACTGCCAG CGCA ACAACAAAGCCTTGGATGCATACCAGAACAGATTTGATGAATTTCATGATTGGCGTAACC GCTT CAAGGCTGCCATGGAAAGGATGAAAGAGGCTGCCAAACCGGAAGAACAGAAGCAAGAGGA GGCA TGGAACCGCCTGAAGCGTGACATTGCAAGCAGCGCACAGACCATTCATGATATTGATACC GGTA AAGCAAGAGGATACAGCCGTGCCTTGTTTGTCAGCAGTATCCTTAATAAAGTAAGCACCT ATGC AGGAAAAGGAGAAGTGGAAATCGTACAGAAAGCGGTGGACTTCATTACAGACTTCAATGC ACAA TGCAAAAAACCGGTTATCACTCCGCGGAACCGTTTCTTCCAACTGCCGGAAATGGCACGC CAGG CCAGACTGAAACTTCAGGAAATCAGAGAACGGGAAAACCGTGAACTGAAATTTGAAGGCG GAAC GCTGGTATGGAACTATGAGGCAGACCGCCTGCAAATCCAGTTTGACAATATTCCGGATGA CCAG AGGCGCAAGGAACTGAAATCATACGGTTTCAAATGGTCGCCGAGATACCAGGCATGGCAA CGGC AACTTACACAGAATGCCGTATATGCAGTCAAAAGAGTGTTGAACCTTCAAAACCTATAAG ACAT GAAAGACCGATTGAAATATGTAATCGATTCCCGCTACTTCGACGGAACATGCCTGACAAG TATG AGTGACGGATTCCATAATGACTATGGTGGGGAAACAATCGAAGAACTGCGCATACGGGAA AACA ATCCCTATCTGAAAGCAGTAACACCTTCTGATATAGACAAGAAGCTGCGGCTATACAATC AGTC CCTGTCCGAACCGTTCAAGGAAATCACTGAAGAAGAATACTATGACCTGCTGGATGTACT GCCA CCCTTGCGCATGAGACAAAACTCGTTCTTTGTAGGAGAACCGTATTACGGAAATATGTAC TCTT TCTGCTTTACTCGTCAAGGAAGATATTTCAAGGGCCTACGCTCCGTACTTACTCCGCAAT CCGA ACTGGACAGTCAGATAGACCGTCACATGGAAATCATCAACCGGAAAGCCGTGATCTCAAA AGAG GAAACAAGTAAAACGGTCACAACCGGAACCAGACTCATTCCCTATTATTTTTCACTGGAC GGAA AACAGCCCGTATTCATCTGCAACCTTGTCATCCAATCAGATTCCAGTCAAGCAAGGACGG ACAT GGCGAATACCCTGAAAAGTCTTCGCCGGAACCATTATCAGTTCTATAAAGGAAAAGGGCA TTAC GAAACTCCGGACGAACTGATAGACCATGTATCAGGAAAGAAGCTCACCCTTGTTTCCGAC GGAC ATTTCTTTCAATATCCTCCCGGCAGGGAATCCGCAACTTTCATCGGACACATCAAGGAGA CATC AGAGGAATTTCTTTTCCGGATCTATGACCGTGAATATTTCCTGTATCTTCTTAAAAGACT GAGG ACCGTGAAAAAGGAATCGGCACAGGAACAAATAAATATCAAATCATAACATTCGGGGGAA TGCG GTAAAATGACTGCCGTATTCCCTCATAAAAACAATACAAGTATGAACAAATCAAACACTC TATA CTGGAAAACAGCCACAGATCCGGCTGAACGCATTGAGGTCAGACTCGTCCTGAACAGTTA TATC GACAATGACAATCTGTATGTAGGACTTGAATCCCGGTCTAAGGAGAATCCGGAATGCTGG GAAT CCTACACGGACATCACCGTCAACCTCAATTCTCTTCCCCCGTTCCATGCCTATGTGGACA ACCG GGACTGCAACAGACATGTGCATGATTTTCTGACCAGTAACAGAATAGCAGAACCTGCCGG ATTT GAATATCAGGGATTCAGAATGTTCCGCTTCAATCCTGACAGGTTGAAGGAACTCGCACCC GAAC AGTTCAAGACAATCAGCGCCAAACTGCCACCACAGGATGACATGATAAAGGACATCATCT ATCA GGAAAGACGTTTCCCTTTGAGAACTGTTCAAGACATTCACGGAATATATCTTGTTTCAAG CAAG GAACTGGAAGAATCTCTGATCGAAGGAGTACGGAACCTGGATGCTGCGGCATATGAACTG CTGG ATGGCATCTGCCTGTTCTGCTCCACACAGGAACTGCGCTATCTTACGGATGCAGAACTGA TAGA AACAATCTACGCACAATAAAAAGGAGGAACAAATATGAAAACCGGAGACATTGTATTTCT GAGA CGTCCCTATAAGGGATACCGTGCCGTCGAACTGATGGAAAGACTGGAATGCCGCTGGCTG GTCA GGATTGTCGAGAGCGGTCTTGAACTGGAGGTATATGAAGATGAACTTATATCAGAATTTT AATA CAGACAAAGTGTTATGGAAAAATATCAGTTTGCATTCCATTCGGAAATAATCGGCTATAC CTCT CCTCATATCGGTGAGGTCAGAAAAGCCATACACAGAAAAGTGGAAAAGGAAAAGTCTGCC GCCA TAAAGAATGATATTGAGCTGCACATGTACAAAGTGCATGACGGCATACCGGTTCTCCTTA ACAC CTGCTACCTGTACGATGAAAAAGGATGTATGGTACACGGAAGTATCAAGGGAACCAAGGA TTAT CTGCTTGAGACATGGAGATACCATACAAACAGACATTCTAAAGGCATCAGTTCCACAAGA ATCA GGCCTTGCACGACAAGCAGGGCTTTTTCATTTGTATAACTCTTAAAATCAGAAATCATGA ACCA GACATTACAACTTACAGACTATATTCCACAGAATGTAAGCCTCTACTACGTGGACTACCG GGAT GATCTTGATGAGCATGAAGACATCCAGGAGGAATGCATCCGTTCCAACAAAATGGAAAAA CTCT ATGAAAAGGCATACGAATGGTATGAGGAACAGGAAAGTTCAAACATGCACGACTATCTGG AGGA GACAAGAAAGAATATGGAAACGGACAATTTAGCCGGAGAGTTTGAAGAGCATGAAGATGA AATC AGGGAACTTATCTACGACCGGAACGATTCCGACCCGGTAAAGGATATGATACGCAACTCG TCCG TCACTAATTTCTTCTATTCGCTCGGAGTGGAAATCAGCGGATATCTGACCGGTTGTTCAC TGCG GGGAGAATCAGTCGCCATGGCCTGCCATAAGGTACGTCGCGCACTGCATCTGAAAAAGGG GCAG TTTGACGAGAAGATTGAAGAACTGGTAGAGAATGCCACATACGGTGGAGAACTGCGCATC TACT TCAACGCCATGTTTGACAGGCTCATCAGCAAAGGCCCTGAGAACGATTTCAAGAGCATCC GTTT CCACGGGAATGTAGTGGTGGTCATTGCCGACAGCCGGAACGGTTCCGGACATCATGTACG GATT CCGCTGGACATCACTTTCCCTTTCCGAAGGGAGAACCTGTTTGTCGATTCACAGGTACAC TATT CCTATGCCAATGAAGTCTGCGGCATGACCAATGACTGGTGTGATTCCACAAAATGGGAAA CAGG CATGATACCTTTTACCGGATCTGTCCGAAAAAGCCGGATGGCTGAATACAAGAAACAGGA AGCC GCTTATGAGCAGACATTCCGAGACGGGAAATGCACCTTCGGTGACATGAACTACAAACGC CACC GTGACGTGCGGTATTCGAATGAATATCCTGCCGGATGCAGGTGCCCTCATTGCGGTACAT TCTG GATTGACTGAAAAAACATTTACCAACCAATAAATTCAAACGATATGAAAATCTGCTGTTC ACAA GAGCATTACGACAAGGTCGTACAGTATGCAAAATCAATCAATGACAAGACACTGGAAAAC TGTC TTGAACGTCTAAAACAATGGGAGAAGAACGAGAACCGTCCATGCGAAATCGAACTCTATT ACGA TCATGCGCCGTATTCGTTCGGATTCTGCGAACGTTATCCGGACGGAAATACAGGCATTGT CGGA GGACTGCTGTATCATGGAAATCCGGACGAATCCTTTGCCGTCACCATGGAACGTTTCCAC GGAT GGAGCATACATACCTGACATATATGCGACAGTCTGTATTGGGGAGCCTCATGCAATATGG GGTT CCCTTTTTTTATGCCGCAGACATGATGACAGCATCCTCATTTCTTGCTGCAAAAATAGCT GTTT GCCGCGCAACTCCCGCAAGGCGGCCCTGCCGGGCTGGTTGTCTGGAAAAAAATCATCCTC GCTT CGCTCCGGTATTTTTTTCCGCCAAGCCTTGCAGGGATGCGGGCAAACAGACAACAGGGAC AACA AGAAATAAGAATGCCTGTACCTTACAGGCAGACAATGTATAACAATAAATATCAGAAGTC ATGA TTACAGACCAGAAGACACAGAACAGGCTTCACGCGGATACCGGAACGGAACTGTTCTCCA TCAG ACAAAGGAAGGAAGCCGTCACAAGGATGCTGGACATTCTGAAAGAGACTCCGGAATACCT GCAG GTTATGAACCATATACCGGCTTATGCCATGGATGACGATACGTCAGAATGGTGGAAATCG GAAG AATCGGAAAATTTCATGAACTCACTCCTGGAAGTGATGGAAAGCTATACTCCGGACGGAT ACAG GTTCGGACCGAAATCCGGCACGACTGACCTTTACGGCTACTGGGAAAGCAAGACCGGGCG GACA ACCCTCTTCCATCTGCTTTTCAGTCTGGAAAGCGGATATGAATGGGGAAAAGGTCTTTCC CATG AGAAAACGGACGCATTCTACAAGGAAATAAAAGAGAAATTTCATGGAGAAGGATTCGACA CGGA CAGAACCGGCTGTACATCACAGGCCATGTATCTTGTAAAAGGAAAAACACGCCTGTACGT GCAT CCGATGGAAATAAGCGGCTACTGTGAAACACTGCATATTCCACAGATTACAGCCATACTG AAAA AAGGAGGCCGTACATTCCGTCTTGTAAAGGATACGATAGCGGAAGAGGTGTATTCCTTCA CCGA TGAAGAAGAACTGGAATATTACCGTGCCAGATACGGAACGTGCATCCACCGGAATATACT GGAT GCCTTCAGCAACCGCCACGCAGGGAAAGAGGACATACTTTCCATGATGGCATCACGGATA AATG TGGCTACGACATCACATCTTTACGGTATCGGATATGATTCGCCTGCATACAGGTTTGTGC ATGA GGCATACGACAGACTGGTAAACAATGGAAAGCTGAAGGAGAATGTCCGGGAAATCGGTTG CTGC AACATCATAATGGCCATTTCAAATACCAACGCAATATGAGACTGAATTACAATGACATGC TGCT TCTGGCAATATGGGAATACAACAGGAGACAGGACGAGGATCTGACCCTGGAACTGTTTCA GGAA ACATTCGGACAGGTTCCCGGCGCACATTTCCATGACAAATGGGTGCATTATTACAACAAG AACC TGCTGATGATGGCCGCCTATTTCAGGGGTGAGGAAGAAAACGGCCAGAAATTCTGTGATA TGAT CACCCGACAGGTTGAACGCTATACACAAAACAGGAGGAGAACAGGATGAATACAAAGATA CGAT ATGACCTTGACAGTCTTGAACTGGCAAACGGTGACTTCGGGTATCCCATTACAGAAAAGG AAGT ACGGAAAGTGAACCGTATGCTGGAACTGATGGAGAATGTCCGAAGCAGGCAGATGTGCCC GACA GAAGGAGACTGCGTGGAATTTGTCTCACGTTCTGGTGACTATTTCGGAAAAGCTCATATA GAAC GGATAACAGGAAAATATGCGGATATATGCCTGATACCGGAAACGGTATTCTGTTTTGATG ACAT GGGAAAAGCCGCCTATGATACCACCGGAAGTCCCTGGACGCAGGTCAATATCCGGAACAT GAAA CCCGCAGGTTCTGAAATCCGCATATTCAGAACATGGGGATTCGGGAAGCGCAGCAATACG GGCA GTCTCAGGTTCGATGCTCCGGTCAGGAAATGGGAATACAGAGAACCGAATCCGTTATATG ACGG TTACACCACCCGTAACTGGTTCCGCTATCATATCATGAAACACCGGGACAGGGAAAGGAC AGGC GAATACACCTTCCGCAGCGATTCATTCACGCTGTACAGCCGGAGCGAGCTGGACGAGCTG GCCG CAATCCTGAAAGGCAGACTCTACAAGGGAATCCTGCCTGACTCTCTTGTACTTTGGGGAT ACCG CATGGATATTAAGGAAATATCACGTGAACAGTGGAACGGTATGGGACAGCACGGACAAAT CCGC ATGAAATTCATGGGATACGGTCCGGTCAGAATCCACACGGACAATGAAAACCATACCGTA ACAG TATACAGAATCAACGACATATTGTCTTCAACTATCAGAATTTTCATATTTTTTCAGTTCT TTTT TTGTTTCTTCTATTAATATTTTAAGCCACTCCATGATTTGTATTGCATGTTCATGAACAG TTTC ATTTTGGCTATCACTGTCGTGTAGTAGCCTTTGAAAATCACGTAAAATATTGTCTTTCCC AAGC ATCTCCCATACAGGCATCATCCGGTGGATTATTTTTCTCATGGTCTCACGGTCGGTTATC CTGT CAGCAGATTCCATCTCCTCCAGTTCTTTTTCAGATTCCATAACAACGAGAGAAAGCATAT GACT ATAATCATCCGTATTCTCCAGTAAACTGGAAAAATCGAATTCTCCGGAAACTGAAACTTG TGTA CGAGATATAATGGTGGATAAAAAAGCAAGCAGTCCGTGGATATTGAACGGTTTATGAATA CAGC CTACAAATCCTTCTTTTTCATAAATTCCGGAATTTCCGTCACCACGGGCAGTCATGACTG CTAC TGGAACAGTTCTAGAATTGCCGATGTCCGAATTGCGAAGCAATCTTAACAAACCGAATCC GTCA GTATCAGGCATTTGTACATCTGTCAAGATCAAATCATATTCAGAATTTTCAAGAGCGGCC ACTA CTTCACGTGCATTCTTACAGGTTTTACAGGATATACCTTTGCGCCCGAGCATATCTTCCG CTAT TTTCAGTTGTATAGGATCATCGTCCACTACAAGAACATTCTTAGGCAATATAGTTATTGT ATTA TGGTCCGATTTGTCTTCCTCAACTAACTCATCCGTTTCAGGCAAAGAAAGTTCCAGTCTG AACA TGCTTCCTTTACCGAGTACACTTTCTACATCCATTTTTCCTTCCAAAACCTTAATTAATC CTTT GGTAAGGAAAAGTCCCAAACCAAACCCTTCAGAATTGACATTCTGTGCGGCACGCTCAAA TGGA GCAAATATTCTTTTCAGTGTTTCCTCATCCATACCGATACCAGTATCCCTTATTTCAATA CGAA GTTTTCCTTCTGAATATTCTGAATGGAAATTGACGTTACCCCTGGAAGTAAACTTAATAG CGTT TGTAAGTAGATTGGCTAAAACCTGTTCAAGTTTGTCCGCATCACCTTTTACTATTACATT TGAT CCTTTATGTTCAGAATATAAAATCAGACCTTTTGAAGTCGCTTTACGAGAAAACTCATCT GAAA TTCGTTGCAAGAAACGGTCAAGATAAAATGGTGTGTCGTTACGCAAATTACCGGCTTCAT TGAT TCGGTAAGCATCCATCAAATCATTAACCAGATGTAAAACGTGTCGACAAGAATGACGGAT GTCA TCTAAATATTTTTCGCGCTTCCTCTTTTCACGCGTTTCAGATACCAAATCTGCACAGTTA TGGA TATTACCAAGTGGACCTCTAATATCATGAGAAACTGTCAGGATGATTTTCTTACGCATAT CAAG CAAATTCTCGTTTTCTTGAATAGCTTGTTGTAATTTAAATTTAATTATTTCTTCCTTACG TAAA TCTGATTGTATAATTAAAAATGAAATTAATATTATAAAAACCGCAATACTCATCATTACG ATAA ATAATCGAAAGGATTCTTGTTTGACTTCCGTTACCTCTAAGTTTCGTTCTATAAATGACA GCTG TACCTGATTATCTAAAAAAGATACAAAATCATATAATTTTTGATTTAACAGCCTATTCTG CAAA CGCAAGCTATCCACATAAGTTTCTATCTGATTGTTTCGCATATCTATGACAGAAACCAAT CTAT TATTAAAATTCTGTATTTCATTAGTTATATAGGGGACTTGTATCGTCTCCTTCTTTCCGA ATAA TCCGGCAATTCCTTTCTTTTTCTGAGTTATTGTCTTCACTTTTACTGTTTGAGTAGCTAT TACA GGCAATTCATTAGTAAGAATACTATCAGATTTATTCGCAAATTGGACTGCTTTCATTATT TGAA ACAAGTGCATTTCTTTCGTTTTAAGCAATTCCCGTAAAGAATCAATTTGAACTGGACATA AAAA ATCACAACTCCTTAATTTTATTTCAAGTAGAACACTATCTGTTTTAAAACGTTGATTATG AAAT ATGTTATAATCAGACTCATCCCATACTATAACTGATTCGCCTAAAGTTGCCAACTTAGTA ATAT ACAAATGAACTTTATTAGTATTCTCATAAGCTTCATTAATTTGAATTATCAGATTCTCAA GTTC TTTCAACCGGCAACGTTCATTTATCATTACAGTAACCATACTTAAGACTATAAATCCTGT AATA AAATATCCAATAAATAGTCTTTTGCGTAATAATGAAGTCATCAGGAACATTCTATTGATT TATT TGACATCATAATTCTATATATTTAACTAGTCATAGTATATATCATTCTCAAATATTTATT TCAA ATTCAAGCAATAAAATAAAAAAACACTTCATATTACAACTGAACTCTTTTATGAAAAAGT TGAA TATATGAAGTGTTTTTTTATTACGATATAAACTATAAAATCCTATTCTTCGGGAACTGGT GTAT AAACCCTTATCCAGTCCACCAGGAAGGTGTGGTCTTCCACATTTTTCAGTTCCTCATCCG TAGG GCTTAAACCTTTAACGGCTCTCCAGCTTTGGTCTTCCATATTTATTATGATGTCCATGTC TTTT ACCAGACCTGTACCACCAGTGTAGTTGTTGGGGTCGATAATATCCTTGCCGCTTACGGTT CTGA CAAGTTCTCCATCTACATAATATTCAAGTGTGAAAGGGTCTTTCCAGAACACTCCTACAC GATG AAAATCGTCGCGCCACAATGTTCCCTTGTCATCCTTATACCATGAGCCAAGATCTTTCGG CTGA TAATCCTTGAATGGCTGGCGGATGAATATGTGATGGCTCAGGTGAAGTCTGTCGGCACCG TAAC CTCCGCCGTCTCTGTCGCCGCCGTATGCTTCTATGATGTCGATTTCCTGAGTATCGTCAG GGCT GAGCATCCATACATCGGATGCCATGGTTGAATTTGAAAGTTTTGCGTATGCCTCTACATA AACC GGATACTTTACACGTGTCTTCGATGTGATACATCCCGTATAGGTTCCCGGCAGTTCCTTT GTGT TGGGTCCGCTTACAACTTTCTTCATGGGGACATCTTCAGGACGGCTGGCTCTTATTTTAA GGTA TCCGTCGGAAACGGAAACATGGTCTCTCTGCCATATTGTAGGAGCAGGTCCTGTCCAATG ATTA TGATAGAAATCGGTCCATTTGGCATAGAACTCTTTTCCTTTATCCTTTTCGTCGGCAACA TAAT TAAAGTCGTCCGACTGTGGATGGAGTTTCCACACCATACCGTCGCCGGCATCAGCGGGTA CAGG ATAGATATCCCACTCGTACGATTTATTATTGAAATCTTCTGCTGCACAGGCTATTTGCAG CGAT GCTAAACAAATGGTAAACAGTTTTCTCATCGTGGTATCTTAGTTTAAGTTATAATAATTA TTTT CGTTCTTTTGATTCACCTTTAGCGGTATGTGTCTGCAATGTCCAGGTAGAAAATCTCATT ATGC TCTGATAGTCTGAACTGTTGTATATATGAGTAAGACCCCATCTCAATATTTCGGTAGGTT CTTT TTCGGCATCTGCACTGCGGTTCAGGCCAATGGCGTGTGGCGCGCCTTTTACTACTGACAT TATT TCAAAGTTTATTCCGTCAGGCGACCACTGGAGTGTGTTCTTTTCAGGACCGTCGGTGGTG ATAA GTGAAGCTATACCTCCTTTGTAAGGCCATACGCAAACTTCATGCCCGCTGTTTGAAATAG GATT ATATTCCGATTTCACATACGGACCCATAGGATTTTCCGCAATAGCCACTCCGTGTTTGAT TTCA CGGCCGCCCCATGTTATTTCTTCTCCCATACGTTCGCCTTTGTAGTACATATAGAACTTA CCTT TATAAGGTATTATACACGGGTCGTGTACCTTATGACTGTCGAAATCACCTTTCGACACTA CCTT GAATCTGTTATCCTCATCGCCTTCCCATTCGCCGGTATTAGAAGGTTCCAGTACAGGCTT GTCT GTCTTGATCCACGGTCCTTCAGGGGAATCAGCACATGCCATACCGATAGTATTCTTTACA CGGA CTGTGTAAGGGGATTTTACCGCCTGATAGCAAAGATAATACTTTCCTTTCCATTCCATCA CCTC AGGAGTGAAGACTGAACGGTCGTCGTAAGCACCTTTTTCACCACGTTTCACTGCAATTCC CTGT TCCTTCCATGTCCATCCGTCTTTTGATGTGGCATACCATATATCACATCTGTCCCATGGG AAAA CCTTATCTTTCTCTATATCTCCAGCAAATCCTTGGGTAGGTCCATAGCTCTTTGAATACC ATAC ATAATATGTATTACCTATTTTCAGCATTGCACTCGGGTCTCTTCTTACTACGCCCTCTTC ATAA GCAAGATCACCTTTAAGTGGTTCCATCTTATACTCAAAGAACCATTTATTGTCGTGATTT TCCC ATTTCATGGCACGTTTCATAGCTGCACTTAACTTATTTCCCTTAGGTATTCCCAATGAAT CGGC CTTACGCTCATCATAATTCTGAGTGTCGTCAACGGCAATAGTCTGTGTATTGCCTGTATT TCCG CATGCTGCCAATAGCGACATCATGCCGGCTGCAAGAATAATTTTTCTCATACTAGACTTT ATTT TATATTAATTGTTAGTTTATTCGAGTGTAATTCACTTGTTTCTGCACTGATATTCAGTAC CGAT GATTTTTCTGTCGACTGAAGCATCAGCATACATCTTCCCTGATATGTCATAATATCCTTA CTTT GATATGGAGAAACGTTCTTCACGTTTCCATTGTCTATACCAAGCAGACGGTACTCTCCAT CAAT GTTGAACTTAAGCATCTGTTCTGTTGTCTTTACAGGATTACCTTTTTTGTCTGTTAGCTG AGCT GTGACATGCAGAACATCCTTTCCATTTGCTGCGATACTTTGTTTGTCAACCGTCAGCAAT ATCG AATGTTCTTTGCCTGAAGTCCTTATAGCTGTAGTGGTATTACCTAACTTATTTTTTCCTT TTGC GGTAATAGTGCCAGGCTTGTACTGAACTGCCCATTTATAGATATGATCCTCAAAATCGTC TATA TACTTCTTTCCCATCGACTTACCGTTAACGAAAAGTTCCACTTCATCACAATTGGAATAT ATCT CTACTATTACCGAGTCACCTTTCTGATAATTCCAGTGAGAGTTTACATCATCCCAAACCC ATAA TTTTCTATCCCATTCATGTCCTTTCTTATCAGTAAATCCATCTTTTACATGGAGATACGA AGAT TTGTCTGTAGTCTGTGAATATATAGCAATAAAAGGCTTGTCTGTCCACAATGATTTCATC ATGT CGTACGAAGGCTTCACATAGCCGCACATATCCAGGAGACCACATCCTATCGACTTTTGAG GCCA TTTTGAAAGACGGCTTTCACTTTCTCCCAGATAATCGACTCCTGTCCATATAAACATACC CGGA ACGAAATCCCTTTCAATCACCGCCTTCCATTCGTGCCACTGACCGAGATTTTCTGTACCC ATTA TAGGCTTGTCAGGATAATTCTTCTTAGCATAATCATACATCACGCGACGGTAGCTGAAGC CTGC CACATCGAGCGCGTCGATATATCCTGACTCAAAGCTTATGGAAGGCAGGATGCAGTTGGC GGTA ACTACACGTGTGGTGTCCATCTGGCGTGTCCATGCAGCTAATTTTTGCGCTGTACGGCCA ATGT CGTATGCATGTTTAGGCTGGATTTTCCACATTTCTCTGATTTTTTCTTTAGAGTATGGAG GCTG ATTCCAGAAATAATTACCGTTGGAATCGGCACCGAAGAAACCTGTCGCCTCGCGGCATCC GGTA TAAGTCCATTCTATTTCATTACCTATACTCCACTGGAAGATACAGGCATGATTACGGCTT CTCC TCATTACGTTTTTCAAATCTCTTTCTGCCCATTCCTGGAAATGCTCGCAATAGCCATGCG TAGG ATAGTCTTCTACAGTTTCCTTCATATTGAGTCTTTTATCTTTGGGATAATCCCACTCATC GAAG AATTCTTCCTGAACCAGAAGACCTATCTCATCGCACAAAGACAGAAACTCTTCCGCTCCC GGAT TGTGCGAGAGGCGGATGGCATTGCATCCTCCTTCCTTTAGGGTTTTCAGACGCCGGTACC ACAC ATCGCGTATCATTGCCGCGCCAACCATTCCGGCATCATGGTGCAGGCATACTCCTTTTAT CTTC ATGTTTTTCCCGTTAAGGAAGAAACCTTTGTCTGCATCAAAACGGAATGTCCGTATGCCG AACC TGACAGTGTTTTCAGAAATTACTTCATCGCCATTCTTGATGCGTGTCTCGGCTGTATAGA GGAC AGGTGTATCGACGCTCCACAAATCAGGCTGTTTAATCTCAGATACGATGTCGATAATTTT CTCC TCACCAGCATTCAGTTTTATACTGAAGACCTCAAAGGCTGCGATATTGCCTTTATTATCC TTAT ATACTACCTCAACAACTGCAGCTCTGGGTTCGGAGTAGCTGTTGCACACGGTAACCTGGT TGTT TACTTTAGCATATTTATCAGTAACCACGGGAGTAGTGACAAATGTTCCCCAAACCGGAAT ATGC AGTCTGTCGGTTACAATCATTTTCACATCCCTGTATATACCTGAACCGGTGTACCATCTG CTGT CGGCATAATGGCTGTGGTCGACCCTTACAGTCATACGGTTATCCTCATTGGGATTGAGAT AGTC TGTGACATCAAAATAAAAAGGAGCATATCCCGAAGGATGATATCCAAGCTTTTTGCCATT TATC CAATACTCAGAATTATTATATACTCCATCGAACACTATATAGCATTTCTGATTTGCACTG ATTG TTGTGGGAAATGATTTGCTATACCATCCTATTCCTCCCTGAAGGAAAGCTACACATCCTT CACC CGAAATGGAATCGTAAGGTAAACCAACACTCCAGTCATGTGGCAGGTTCACTTTCTTCCA TTCA TCACCAGGGACATAAGAAGTATATGAATAATGAGCAGAATCTTTCAGTACGAATTTCCAA TCTT TATTGAAATCAACATTTGAATCAGATGCTGAAACCTTTAGGGTTGATAATAGGATTATTA AAGC TAAAAGATTTTTATTTCTCATAATCTTAGGTTTTACATGTTTTTTGATGTCACAAAACTA TATC TTTCACTTATAATATATGAGGGGGATATTAATGTGATATAGGGTGGGAAATCAGAATTTT ACAT CTGCCCTGTATTCCACCGTCACCTACAACCTTGACAAAGGATGTTCCTTTCTTCCCTCTT ATGG TTCTCAGGACAAACAGACACTTTCCGTTATATGTCCTTACACTATTGTTTATGACGTTGA TGTT CAAATCTTCTATCGAAGGCGATCCATTGTCGAGTCCGGCAAGTTCAAGCTTGTCGTCGAG GATT ATCCTCACATCCGAAGGTATATCGACTACTGTGTTTCCTTCTTTATCTTCAATGGATACT TCTA CATGGATAAGGTCATAACCGTTGTCGGTAGCTGTTTTGCGGTCGCAGTTCAGTGCCAGAC GGCA CGGCTTGCCGCTTGTGGACAAAGTGTCTTTCGACAATATTCTGTCGCCGTCCTTGCCTAC CGCA AGGAGTGTTCCTTCCTTGTATGCCACCTTCCACATCAGTATATTATGCTCCATGAAATCG CTGC GTTTCTTTGTTCCCAACGATTTGCCGTTCAGAAACAGTTCCACTTCTGGGGCGTTGGTAT ATAC CTGCACCAGTATGTCCTCGTCCCTGCGGTACTTCCATTTATCGCGTGTGTCGTACCACTC CCAG CGTCTGATCCATCCCGGGCGTGGAGTGTAGGTGAAACTTCCGTCAGTATCCATCTTGAAC TCGC TTTCCTTTTCAGGTATTGTTACAATATGGGTTTTCGGTGTGTCTTTCCACAGACATTCAA AGAA ATGGCCACGCGCTGTCTTGTTGCCCACGAAATCGAAGAAAGAACAGTCTCCACCCCTTGC AGGC CATGGGCCGTTCTCGCCAAGATAGTCGAATCCTGTCCACACGAAGATGCCCGCTATGTAC TTCT TGTCGGCCACGGCTGTCCATTCAAAGAGCTGACCAACATTCTCCGAACCGATAATAGGCT GATA TGGATATAGCTTATGGTCGATTTCATAATATTTGTCTTTATAGTTATATCCCACTACATC AAGA ACGTCTGTATATCCGGAGAGACGCGAAACTGACGGAACAACGACTCCTGAAGAGACGGGA CGGG TAGTGTCCACATCCTTAACCCAACCGGCAAGGACAGCGGCTGTTTCAGCCAAATCGTCTT TTCC TCCTGACAGACGGTTGAACTCTTTCAGTATAGACTTGTTGTCTGTTTCCGGGTCGCCCGT ATGG ATAAGACCCTTGAACCCTTTATTGTCTTTGCTCGATGCCCAGTAATATGGATAGGTCCAT TCTA TTTCATTGCCTATACTCCAGAGTATCACGCAAGGATGATTTCTGTCTCGCCTGATGAACG ACTT GAGGTCGTGCTCGGCATGCGTATCGAAGTATCTGGTATATCCTATTGATATGCTGTCGGG CGCA TCTTCCTTAGCTCGCTCAGTAATCCACTTTTTCTTTGCCACCTTCCATTCGTCGATAAAT TCAT TCATTACAAGAAGTCCCAGACTGTCGCACATTTCCAGCAGACTTTCCGAATGCGGATTAT GGGC TGTACGTATGGCATTGCAGCCTATGGAACGAAGTTTCAGAAGGCGTCGCAACAGGGCATC ATCG TATGCGGCAACACCCATACATCCCAAGTCGTGGTGTATGTTCACTCCTTTTATTTTTACT GATT TTCCGTTTAGAAGGAAGCCTTCATCCGCATCGAATTTAATGTCGCGGATACCAAATTTTG TTGT TTTCTTATCCATCACATATCCGTCAGAAGCAATCAGAGTAGTATGAAGCTCATACATCGA AGGC GTTTCAAGACTCCAGAGATGACAATTCTCCAGTTCAACAGATGCAGTGAACTCATTGAAA TCGC CTTTCAGGGCAACAAAATCATCGGAAACAGAAGCTATTGTCTTGCCGTCGTACACTACTT CGTG CTTCACGGTGACTCCTTTTACACCTGTTCCAGCATTCTTCACCTCGCATACCACATTCAC CATC GAACGGTTGCCTACCTGTGGTGTGGTAACGAATATTCCGTCTGAAGGAATATAGAGCTCG TTTC TTAGAATAAGACTCACATTCCTGTATATACCGGCACCGACATACCATCTGCTATCGGCAT ACGC TCTTCTGTCAACGCAGACAGTTATTGTATTCATCGAACCTTTTGGTTTCAGATATTGAGT AAGT TCATATTCAAATCCCACATATCCGTTAGGACGGAATCCCAACATATGCCCGTTTATCCAA ACCT TTGAGTTATTATATACACCTTCGAAATGAATGAACACTTTTTTCCCATTCATATCATCCG AGGT GAGAAAATTCTTCATGTAAATCCCCACACCGCCAGACAGAAAACCATTGCTTCCGGCTGT CTGA GTCTTGGTATATCCTTCGCTGATACTCCAGTCATGAGGCAGACACACATCCTCCCACTTT ATAT CTGGACTCAGGAACAAAGTGTCCTGAGGCACGAAACCTGCTGGTTTGCTGAATTTCCAAT CGAA GTTGAAATCCACTTTAGTGGAGGTTCCGGCATAACAGAATCCGGACAGAAAGATAGTTAA GACT GTGATAATGTTTTTTATGGTCATATCGATTTTCAGATTAATATTAATGACAAAAATAATT TCAA AAGTGTAAAAACAAAAAAACTCTCCATTTATATTTCAGATATCAACGGAGAGTTTCATCA TTAA AAAAAATAAAACATTTTATAAAGTTACTCCTTGCTTAAGGATAGCTATTTCCCGGTATCC CTTC TTTTCGTTCAGTGCCTGCTTTCCGCTTGCCACTTCCACCACAAAGTCTATAAAACGTCTG CTTA AAGATTCCATGCTTTCTCCCTCTACCAGAGTTCCGGCATTGAAATCAATCCACGTATGTT TCTG TTCATAAAGCGGAGTGTTGGTCGAAACCTTCACGGTTGGAACGAATGTTCCGAACGGTGT TCCG CGGCCTGTTGTGAACAGCACGATATGGCATCCGGCAGAAGCAAGAGCCGTACTTGCCACT AGGT CGTTGCCTGGTGCGCTCAACAGGTTAAGTCCGTGTGTTGTGACACGGTCGCCATATTTCA GAAC ATCCTCCACCATCGAGCTTCCCGACTTCTGTGTACATCCCAATGATTTCTCCTCAAGCGT GGAA ATACCTCCCGCCTTGTTTCCCGGTGAAGGATTTTCATATATTGGCTGGTCGTTGCGGATG AAGT AGTTCTTGAAGTCGTTTATCATGGCCACTGTGTCGTCGAATATCTCCTTCGTGCGGCAAC GGTT CATGAGCAGTGTCTCGGCTCCGAACATTTCAGGTACCTCCGTGAGGACTGTTGTCCCACC CTGG GCAACAAGATAGTCAGAGAACACCCCAAGCATCGGATTGGCCGTGATACCGGACAGTCCA TCAG ACCCGCCGCACTTGAGTCCTATACGCAGTTTTGACAGGGGGACATCAGTCCGCTTGTCTT CCCT GGCTATGGCATACATCTCACGGAGAAGTTTCATACCCTCTTCTATCTCATCATCTACTTT CTGA GAAACAAGGAAACGGATCCTTTGGGTATCATAGTCACCTATAAACTCACGAAAGGCATCA GGCT GGTTGTTCTCACAGCCAAGACCTACGACAAGGACAGCTCCGGCATTGGGATGAAGGACCA TGTC ACGCAATATCTTACGGGTGTTCTCATGGTCGTCACCCAACTGCGAGCATCCGTAGTTATG AGGG AAAGATATAATGGAGTCAACCCCCTCGCAACCTGTTTCCTTGCGAAGCTGCTCGGCCAAC TGGT TTACTATTCCGTTCACGCAACCCACCGTAGGGATAATCCATATCTCATTACGTATGCCGG CTTC TCCGTTAGCACGCAAATACCCTTTGAATGTATGGTTCTCGTTCGTGAATGTCTGTTTCTC GAAC TTCGGAGTGTAAGTGTATGTACTCAGACCGGAAAGGTTCGTCTTGACGGTTTTCTCGTTC AGCA GATGTCCTTTCCTGACTTCCTTTACAGCGTGCGATATGGGGAAACCGTATTTTATCACCA TATC ACCTTCTGCAAAATCCTTCAGGGCAATCTTATGACCGGCAGGTATATCCTCCATTAATTC TATG GAATTGCCGTTCACCTCTATTACAGTCCCTTTGGACAATGGGTGCAGTGCCACAGCCACA TTGT CCGCAGGGTTTATCTGGATATATTCAGTCATAACAAACTAACATTTATAAATTGAAGAAT ACAG GTAGAAGTATCAACCTACAAGGTCTTTTACTGTCTGAAGCATTCCTTCGCTCTGGATTTT GTTG ATATAGTAAATTACACGGTCTGCCAGTCCCGAGATAGTATTAAGGTCTTCACCCCAAATG GAAG TATCGGCGAGAACTGTCTTCACAAGATTTTCTACCGAGCCATCGTTCCACAAACTTGTAA GCAT CGCCATGATTTCCTGTGCATCGTTAGGAACTATCTCTACACCATCGGCACGCTTTCCACC TTTG TAGTATACTATGATGGCTGCAAGACCGAGTACAAGTCCTTCAGGAAGCACACCCTTACGT TTCA GATATTCCTTCACTCCTGGAAGGTCGCGTGTGGCATACTTAGGGAATGAGTTAAGCATGA TTGA TGTTACCTGATGGTCTACGAAAGGATTATTGAAACGTTCCAGGACATCATCGGCAAACTT CTTG AGTTCCTCTTTCGGCAGGTTGAGGGTCTCCATCAGCTCGTCGAACATCACACGTTTGATG AACT TGCCTATCACCTCATGTTGGCATGCGTCTCTCACGATATTGACGCCCGAAAGGAATGCCA CCGG CGACAATACAGTGTGAGGACCGTTCAGCAGAGTAACCTTGCGTTCATGATAAGGCTCCTC CGAC GGGACGAACAGAACGTTCAGTCCCGCCTTGTTTGCAGGAAATTCTTCGGCAACCGATTCC GGTG CTTCGATAACCCACAGATGAAAAGCCTCGCCCTGTACAACTAAATTGTCATCAAAGTATA GTTT AGTTTTTATGTTGTCTATGTCTTTACGAGGGAAACCCGGTACGATACGGTCCACCAGTGT GGCA TATACACCACATGCAGTTTCAAACCATGACTTGAACTCTTCGCCAAGGTTCCACAATTCA ATAT ACTGATAGATTGTTTCCTTCAGTTTGTGACCGTTGAGGAAGATAAGCTCGCATGGGAAGA TGAT GAGTCCTTTCGACTTGTCACCGTTGAAATGTTTGAATCTGTGATAAAGCAACTGTGTCAG CTTG CCCGGATAAGAGCTTGCAGGAGCATCCTCAAGCTTGCACGACGGATCGAAGTTGATACCG GCCT CAGTAGTGTTCGAGATTACGAATCTCATATCAGGCTGTTCCGCCAGTGCCATGAAGTCAT TATA CTGGCTGTATGGATTCAGCGCGCGGCTGATGACATCAATCATTCTGAATGAGTTCACCAC CTCG CCATTGTTCAGTCCCTGAAGATTGACATGATACAGACAGTCCTGGGCATTGAGGGCATCA ACCA TACCTTTTTCTATAGGCTGCACCACAACAACACTGCTGTTGAAATCTGTCTTTTCATTCA TATT CGAGATAATCCAGTCGACAAACGCACGAAGGAAATTACCTTCGCCAAACTGTATGATACG TTCC GGACGTACTGCCTTTACTGCAGTCTTACTATTTAAAGCTTTCATTGTAATGCCAAAAAAT TAAA ATTGATAAGATTAAAATTCAACCAACATTCTGAATACCTTACCTGGATTTTCCGACCATT TCTG CAGAGCCTCGCCTGCCTCTTCAGGTTTCACTACGGCAGAGATAAGTTCGTTCATCGGGCA GTTG CCATTCTGAAGATAATGTATCACGGCACGGAAATCCTCAGGCATTGCATTGCGCGAACCG CGTA TGTCGAGTTCCTTCTGGACAAAATATTTTGTCTGGAAAGCCACTTCACTCTTGGCATAGC CGAT ACATGCCACACGGCCTGTGAAACCTACAATGTCGATGGCAGTAACATATGTGATAGGACT ACCC ACAGCCTCTATCACCACATCAGCCATATAGCCGTCAGTAAGTTCCCTTACTCTTTCCACC ACAT TTTCAGTCTTCGAATTGATAACCATCGAAGCACCCAGGCGTTTTGCCAGTTCAAGCTTCT CATC GTCAATATCCAATGCTATTACCCTTGCGCCACGAAGCGATGCTCTTACTATGGCGCCAAG TCCA ATCATTCCGCAACCAATCACGGCCACAGTATCAATGTCAGTTACCTGAGCTCTCGACACG GCAT GGAAACCTACGCTCATAGGCTCAATCAGCGCACATTCCTTATCCGAAAGACCGGCAGCCG GAAT AACCTTTGTCCAAGGGAGGACAAGGAACTCCTGCATAGAACCGTTACGCTGAACACCCAA AGTC TCGTTGTGTTCGCAGGCATTCACACGTCCGTTGCGGCATGAAGCACACTTTCCGCAGTTG GTAT ATGGATTTACTGTCACGTTCATTCCCTTCTCGAAACCGACAGGAACGCCTTCGCCTATTT CCTC TATCACAGCACCCACTTCATGTCCCGGGATGACAGGCATCTTCACCATAGGATTTCTTCC CAGG TAAGTATTAAGGTCGGAACCACAGAATCCGACATATTTGATACGAAGTAAAATTTCTCCG GCTC CAAGTGTTGGTTTAACTATATCAGCTACTTGAACCTTTCCGGCTTCAGTAATTTGTACAG CTTT CATAATCTATGTATTTATTTAAATTTGTTATTGTATTATTTTGATGTTGCATTAATTCAA TGTT GTTTTTTCTCTATCTTATATCCTCTCCAGCCATAATATGCCGTAAAGAAGAAACATATCA GAGG TATTACATATGCCACCTGATAGAAGTCCGCGTTATGATTCATCACAAATGCGGTGAACTG AGGG ATGCACGCATTACCTATAATAGCCATCACAAGGAATGCCGAACCACTCTTTGTGTCCTCG CCAA GGTCGCGTAGTGCAAGTGAGAACTGGGTTGGATACATTATCGACATGAAGAACGACACTG CAAG CATGGCATAAAGTCCTGTCATACCACCGAACATGATAATTACTCCACACAGTATGATATT TACT ATAGCGTATGTAAGCAGCATATCCTGAGGTCTGAATTTCGACATTAGCATAGTACCTATC CATC TGCCGCCAAGGAAAGCCAGCATATACAGTCCGAAGAATGTGGTCGCCTCATCCTCCGACA GACC TGCATACATGCAGCAGTAAACTAGGAACAGGCTGTTGATGGCTGTCTGCCCTCCGTTATA GAAG AACTGTGCGATAACTCCCCATCTCAGGTGTTTGCGTTTCAACACTGCAAAATTGATAAGC TTGC CCTTCTCGCCGTGCGATTCCTCCTTGTCAATATCAGGCAACTTATACAGTGCAAACACCA CAGC AAGAATAATCAGCAGGACTGCAAGAACCAGATAAGGCATCTTCATGGAGTCTGTCTCCAT CTGA ATAAATCCGTCCCAACCTCCGGGAAAGTCGGCAGGCAGAGTCTCGCGAGTATAGTTCTGT CCGG TAAGTATAAGCTTACTCAGAAACATTGCGGATATGAAAGCACCAAGACCGTTGAACGACT GTGC AAGATTCAGTCTTCTTGAAGCCGTATCGTGTGTACCCAGAGCTGTCACATACGGATTGGC AGCA GTTTCGAGGAAGCACATTCCCGTTGCCATGATGAAGAAGATTACAAGATATGCCCAGTAT TCCT TTATCTCGGCTGCAGGGAAGAAAAGCAGACCACCGATGGCTGCAAGAATGAGACCGACAA TTAT ACCCGACTTATAGCTGAAACGTTTCATGAACATTGCTATCGGTATGGGAAACAGGAAGTA GGCC AGCCAATAGGCAGCTTCAGTGAACGAGGCCTCAAAAGCATTCAGTTCACAGGTTTTCATC AACT GCCTGATCATTGTAGGCAATAGATTACTGCTGATAGCCCACATGAAGAACAAGCTGAATA TCAG TAAAAGCGGTATAAAATATTTGTTTTTCATTCTGACATGTTTTTAATATAAGGTAACTCA GGCA GATTCTTGAAACCGTAAAAGGCTTTCGCGTTCTCGCCCAAGAAAAGTTTTTTGCTTCTCT CTTC CAATTCTTTTGATTTAATCACAAAGTCGTACGACATCTTGTAGGTAATGGCTGTGATTGT GCGT GGATAGTCGGAACCCCACATCAGTTTCTCGAAGCCAACAAGGTCGGCAGCTTCGTTGATG GCTC TGACAGCGCTGCGGAACGGATAGAACTCGTCATTGAACAGCCAAGTGATACCGCCCGACT CAAT CATCACATTCTTATGACGGGCAAGCATTATCTGCTTCTTCCAATCCGGTTTAGTCACCAT ACCG AAATGCCCGATGGCAATCTTCAAGTACGGACATTCTGAAATGATTTCTTCCATCTCGCCC ACCT GGAGGTCTCCCTCTGCCATATCTATGGAAAGAATCACCCCCTTGTCTTCCATTAGATGAA ACAT CCTCATCATCTCGTCCGAGTTGAGCATCACCCTACCGTCCTTCAGTTGCAGGCGGTGTCC CGGA ATCTTTATGGCCTTGAACCCTTTGTCTATAAGTTCAACCGCCTGGTTATAGAAACCCGGT TTTC TGAATTCACACATACCACACACGAAGAACCTGTCCGGATATTTCGTCATCACCTCCATCA GATA GTCATTCTGAATGCCGTCGATATACTCCTGTGTGACAACAGCCGCGCCAATCAGGGCATA ATTC ATATTAGCCAGGAAAACCTCAGCCGTGTTTCTTCCGTCAATCATAAAGGGGGGGGGAGCA TTTG TCTCACCTCCCCCATAAACAATGATTGACCGTTCTCTGTAGTCTTGATTTTCAGGCCATC TACT TCAGTGTCCTGATAAAGCCACAGATGCGAATGGGCGTCAATTATTGTATAATCCATAGAA ACAG TATTTATGAATTTGCCCAACTTACTCTTTGCTGATCGCCTATTATCTCCTTAACCTTTTC CACA AGGCTCCAGTCTATCGGTTCCTCAATGTATTTTATGTTCTGAAGCACAGACTCTGTTCTT GCCG AGCTGAACAATGTTGTAGGTATTCTCGGATTGCTTACAGAGAACTGCACCGCAAGTTTCT CGAT AGGGTATCCCTGTTCAGCACAATACTTGGCAGCCTTTGCACACACCTCAATCAATGGTTT TGGA GCCGGATGCCATTCAGGAACACCTCTATGTGTGAGAAGTCCCATACCGAACGGCGAAGCG TTTA TCACTCCCACACCATTTTCGTCAAAATAGTCGAGGAAGTCCACCAGCTTGTCGTCGTTCA ATGA ATAGTGACAGAAGTTAAGCACCGCCTCTACTGTACCCGGAGCGGCATGGTCGATAATCCA TTTC AGGTTTTCGAGCTGCAGGTCGGTGATACCCACGTGGCCCACCACGCCTTTCTTCTTCAGT TCCA CCAGAGCAGGCAATGTCTCGTTCACCACCTGGTTCATATCCGAGAACTCAACGTCGTGAA CGTT GATAAGGTCGATATAGTCGATGTTCAGACGTTCCATACTTTCGTAAACACTCTCCTGAGC GCGT TTGTCCGAGTAGTCCCACGTATTCACACCGTCCTTGCCATAGCGTCCCACCTTTGTAGAA AGGA TGAACGATTCTCTTGGCAATTCCTTCAGAGCCTTACCCAATACGGTTTCGGCTTTATAAT GTCC GTAATATGGAGAAACATCAATAAAGTTCAGTCCGCGTTCCACTGCTGTAAAAACAGACTG TATA GCGTCACTTTCTTTGATAGAATGAAAAACTCCGCCCAATGAAGATGCGCCATAACTCAAT ACAG GAACCTTAAGTCCTGTCTTTCCCAATTCACGATATTCCATTTTTGATAAATAATTTAAAG GTTA ATATTTTTTACTCTGTTTATTCTTATTCATACAGATAGAACATACGTTCCATCATCTTCC ATTT CTCGTCCGATGTGGCCCCCTCGGCACACTGCTGGAATTTGGCTACGTATTCTTCCCATTC GGCC TGACGCGGCAGAGTGGCAAGCTTTGCCATAGCTGTATCCCAGTCAAAATCCAGAGGTGTT TCCA CTATCATAAAGAGTTTTGACCCCAATATGTATATTTCCATTTCCAGGATTCCCACCTCGC GTAT TCCGGCGCGTATCTCAGGCCATGCCTCTTCCTTACTGTGAGCCTTTCTGTAGGCTTCAAT CAAT TCCGGATTCTCACGCAGACTCAATGTCTGACAGTATCTCTTCACAGGCAGGGAATAACTT TTCA CTTTATATCCTTCTGTCTTCATGATATTATTGATATTAATATGTTAGTATTACATGTCAC TGTC TTTATCTTTTCGACGATGCTAAAGTATGAAGTATCCATCAAAACAATAGAGGAGATTTTC AAAA AAGAAAGAGGGGATATTATACCCCCTCTTTTTCGACATTTTTACCCCTCATAAAGGAGAT AAAA AGTCACCCCAAACTCTATAAAAAATCAAAACAGATTGAACTGCATTCCTGTGTAGAAAAA TCCC TGGTTGGATTTCGGATTCCAATACGTCATCACCGTCAACGGGATTTCATATTCCATAATC CGAA GTTTATAAATCACATTCAGGGACACCTGAGTAATTCCTGCCGATTCGGCATACATGGTTC TGTT CACCATTTCCCCGCTTTCATTTCTTGAATTTCTCAATGCGAAAGCTGTTCCAATACCAGG ACCG ACCCTTAGCTTTTCGTTCTGATAGATGGTATAGCCCACATATACGAAACTGGAGTAGATG TTCT TGCTGTTGTCCAGATCCCTGTCGCGACCGTAAACAAGTGTAGAGAAGCTCAACTCCAGCG GAAA TTTCCTGTCGCCCGTATAATTGACCATGAGATCAACGAAACGTCCAGTTTCATCAGGCTT ATAG TTGAAGAACTCCTTATTATTATATGTAGCCCCGGGCGAGAAATTATATGTATCTATAGCC TTTA TCTGAAACCTGCCATGAGTATATGCTATATACTGGCTCAGCTCCTTATAACTCCCCCTGG TGTT CGATCCGCCAAGGAAACCGGCGGTAAACCTCCCCGATGGGTCGGAAACCGACAAATCGGA CGAG AGAATCAGTCCGTCGGCCACTTCAATGCCACGCCATAGAATCATGTTCTGTAGAGTAGTA CTGA AATGAAGCTGAGCCTGAACATTTGCTGACAAAAATATAAATACAGGAATTAACAGTCGCT TTTT ATACTTACAGGTATCCAATGATAATATATGTATCATACTCAGAGCAGTAGAAAATCGGTT TTAA ATTATTATTATGGATTTATTTGTCGAAATACTCTATAAGATTATAAACATTCCAGTTAAT ATCC GACATGTATTTGGTCAATGATGTATAAGGTTTATAGTTATAATCGAGCATACCTTTATTG CAAT CCTCATCATCCAGATACTTGAAGAAAACCCATCCTACACAATTCTTGGCTTCGAGCAGTC CCAA GGTAAAATGCTGGTAAGCGAATCCACGGTTTTGCTGGTCGCGTACCACGAAACCAGCTCC ACTT GAATTGTCAAGCTTAGTATCCTCACCCTTGGTATAGAATTCCGTTACCATGAAAGGAGTA CCGC CCGCCTGGTTCTTCCAGCCATCCATGTAGCCTTTTTCAGGCGACCATTTACTATAATAAT TTAT GGAAATGACATCACAATATTTTCCCGCTGCCTTAATTATATAACTGTTGTATTTAGGAAG GCTG TGCAGGCGTGAACCCAGATAAAGCAATTCAGGATCCTTCGATGCCTTAACCGCATTCTTT ATGG CAGAATAATATTTTTCCGCACAAATACCGGCAAACTCATTGTTCAGTTCATCCGTTACAT CAGA AACATTTGCACTCTTGTCCTTATCCGTCATAAACTTGGCGGCTGCAATATAAGCAGGATC CTGC TTGTTTGAAATTTTCAGGAATCTGTCGAGCAGCCTGTTTCCCCATGTAGAGAAGTCTATC TCAT TATCCGAGAAGAATCCCAACACATCCGGGTTGTTTCTGAACATGCCGAAAGCATCCGAAT TGAG ATACTCCTTGCACCATTCATCCCATCCATCATAAAACACAAGACCTATCTTAAGATTCAC GTTC TGCCCCGGATAGCTAATTCCCTTGCTATTCTTGAACTCTGCAAGGAATGAAAAGGAAGGA GCCT GTGTCAGAGGACTTGAAGCCGATTTATTATAATCATTTACAGCCTTGTCGCCTTCTTCCT TACC GAAAGCGCAGACACTATGAAATCCTATTTCAGAGAATTGTTTCTGCGACTTTGCCACCCA GTCA TCTACTGAACTGTAAAGCTTGCCGAAAGCTGAGCTGTTGCCATCCATTCTGAATGAGGCG ATAC CCCTTACATAATATGGATAACCTTCGGGGTCGACTATCCAACTTCTTCCATTTGAGTTTT TCTC AACCCTGAACCGTCCAGTAGCCTTGGATTTTTGCCCTTTTGCGTATGAGCCATATTTATT CACG CTTTGCAAATACTCATCCTGTGTTTTTGTCTGCTGTTCATAACCAACCAGGTATGGCAAT ATCC TTGTCTTTGCCTCTATAAAAGCCTTGTCAGGTTTTTCCGCATACTCGACAATTATCGGTT GATA CTGCTTGGTGCTATTAGGATAGGTTTCAGCAGGACCGGGAACAGGCAGTTGCAGTTCTAC ATCA TCATCGTCATTATCGCCTGCATTGTCGCCGGGAGTATTATAGTCCTCCACATTCCCCGGT TGTG AGTAAATAACCTCAGGCGGAATATATGAGAACTCCTCCTGAGGGTCTTCACATGACAAAG CGAA GAACGGAACACTCAAGCAAATGGTTTTAGTAATAATAGTAGAATATTTCATTGTTGCAAA TATT TAGTAAATTAATATAAATCCCATGTCCTGATTGTATCCCCCCATCGGTGGTCTATCGGGA ACTC CATTTCTCCCCATGCCTTAACAGAAGTCCAAGGTTGGTCGGCATCAGTCCAGAATGGGTC AGAG GCAGGCAATCCCAACGGAAGGAATGCAAGTGTAGTCATATACAGGCTGCCATTGTTTGTA TAAT GATTCGAAATGCCAGTCTGATGTCCGCAGAATCCTATGGTGAGGAATCCGCCCTCATTGA AGTT ATTGCCCGACTTGAACATACGTTTCATACACGCTGTCAGCGCACATCTCACCTGTGCTTT CGAT ACTCCCGCCGGCAACTCATTATACCATGCTATAAGAGCCAGTGGCTGCATTGTTGCCATA CGGT AAGGTATAGAGCGTCCGAAAACAGGGAATGTTCCTTCAGGAGATATGAAACGCTCCAGAA TCAT GGCGAACCTCTGTGCCCTCATCAATGCCCTGTCATAGTACTTGCGATAGTCGAAACGTGT CCTC ACGCCCGATTCCATTATTGCATGTATAGATTCGAGATACATAGGATGGAACACATAACTG CTAT AATAATCGAATGCAAAGTGCTGTCCGTCTGCGTACCATCCGTCGCCTACATACCATTCCT CCAC CTTGCGGAAAGTAGAATTTATACGATATGTATCCTGTCCGGCATCAATTTTGGCAAGGAA GCTT TCAATGGTGGCCGAGAACAGCAGCCAGTTAGTGTAAGGAGGGTCAATGCGTCGGAGACCT TTGA ACTCTTTTATGTAGCGTTCCTTTGTTGTCTGGTCCAGCGGTTTCCACAGCTGGTCGAACG CGCG CAGGAAACTTTCCGCAATATAGGCAGCATCAACCAGTGCCTGACCATGACCGTTCCACAA CAGA TAATCCGGACTATTAGGGTCCACCGCATTTGCATAACTCTTCAATGCCCATTCTTTCAGT TGCT TGCGCTGCTGTCCTTCTGCTGTATCATCGTCAGGCAGGCTCAACCATGGAGCTATACCGG CCAT GAGACGTCCGAAAGTTTCCATATATGCAACCTTCTTGTTACGGTTATCCCAGTTTGGACT TACC TCAAGAATCATATTTTTCTGCAGTTCCCCTTTCGCCATATTGCTCAACACAGGAGCAGCC ATCC TGTAAGCCATATCCGTCCAGTATTTTCTTGTCTCGTTGTTGTTTGCCTCGAGATAACGCA CATA CTCGCAAGCGGCAAGAAGGAATGCGCCTACCCCAAAGTTGGCAGTCGACTTGGCGTCAAC CACC TGTCCCGGAATAGCCTTTTCACCGATTGGCTGGACATAACCCACCGACCAGTCTTTCTGC AGTG CAGTCTTGGTAAGATATTTCCATGCTTTCCCCACTACAGGCATAAATTCATCCTTGTCAA GATA ACCGTTGTTTATCCCCCAAAGCATACCGTAAGTGAAGAAAGCGGTACCGCTTGTTTCCGG TCCC GGAGCATGTTCCGGATCCATCATACTTCTTGTCCAGTAGCCCTCCGGCTGCTGCAGACAT GCAA CCGCCTTTGCCATACGCACAAACTTATCCTCGAAAAAAGACAGATGCTCATAACCCTCCG GCAG GTCCTTCAGCACCTTTGCCAGAGCGGCAAGCACCCATCCGTCGCCTCTTGCCCAGAAATC CTTC TTTCCGTTCAGACTCTTATGCTTGGGATAAACATATTTTGCGTCGCGATAATAGAGTCCT TCCT CCTCATCATACATTATTGAGTCCGACGTACAAAGATATTCATACAGTTTCTTAAGATACC GGTG ATTATGCGTAATCTTATACATCTTCGTCATTACCGGCATCACCATATAAAGTCCGTCGCT CCAC CACCAGTAATCCTTACGCGGTGTGCTCATCTGGTACTCCATGACTTCGCGTGCACGCTTG ATTT TATAATTCTCCGGCATGACGTTATACAAGTCCGCATAAGTCTGGAAGCACACCTGATAAT CGCC GAACAGCACATAATCATCCTTTACCCCGTATTTATACTTCCATTCAGATTTGTTGTTGCT TTTC GCACCCATCCACTGGTTATACTCAGCCCATGCCTCCGAATACTTTCTGTATTCTTCTTTC CCAG TAAGGAAATAGGCTTCCATATTACCGGTGTGATATGCCGCATAATCCCAGAAAGACCTTG CTTC GGGGGCATGATTTTTCTGCCAGGCATCGTTCACTTTTTCAATCATCTCCCTAACTTGCTG AGCC TCAGTTTTTTTTTGCGAAGGAAAATGAAGGTAAAACAGCTATAAGGATGTATAACATCCA GTAG TATCTATAACAGTTCATCTTTGTGATATTGTTTACATTTTCTAAAACGAAATGGGGAAGA ATAT ATATTCCTCCCTCATTTCACGAATAATTGTATTATTATATTTATTTGTTAGGAGTCCATT CTGC TCCGTTGTTGAAACCTTCTGTTGTAGAGTCAAAACTTGCATCTGCTCCTGTACTTGGTCT TTCT GTAATTTCTTCAATCTTAAAAGAAGTGATTTTAGCGGTTCCAGTAGCATCAGTACCACCA GGGA CATTAGTCTGTACAGTTAAAATAACGTTCTCAAGAACCGGCCACACAAGTGAACCATCTG CTCT TGAAGCTGGAGTTTCAGCAGAAGTAGAACTACTGATTGTGAATGTATTTGTATAGGTTCC ACTT CCGGTATTTCTTCCAATCCAGAATTTATATTTATCAGATGCTCCCAATCTGAATGTTGTT GCAC AGTCGTTAGATGCGTATGTATAAGTAAATTTGTAAGTACAACCATCACGGAATGACATTG ATTT AGTAACTGGGAATTGATTATCTGCTGGAACAATTTCCAATTCTCCACTTGCATTAATTTT TTCG GCAACTCCTTCTGCAAGATATTCCTTAACTGCATCTATGTTAGCGAAGTTAAAATCAAAA GCAT CTGCATGAGTCAAAGCAACATTGGCAGATTCAATCTTGATATTAGCATCTTCGTTGTTTT CGTT TTTAGCAGTCAAAGCACTAACAGCATAATCAGTGTTATAACTTACGCTAATATTTGCGTC ATTA CTATAAATCTTATCACCAAGAATAAGAGTCATAGTAGTTCCATTCACAGAACCGGAAGCA ACAG GAATTGTTTTTCCTGCTACTGTTATGGTAAATGCTTTGTTAACAGCATCAGTGAATGTTC CAGA AACTTCCTTATCGAGTGTAAGTTCAATTCGGTCATTACCTGTTGTCTGATCAGGAACAAT TTCT TTAGCTGAAGAAACGGCAACAGTAGTTTGTTTTTCCAAATCCACAGGAGGTTCACCGCCT CCTT GATCATCATTCAATACTATCGTTACAATCTGTCCTTTAGTAACTATAAGGTTTTCACCAC TGAA GTTATAAGTTTTAGTACCAGAATTTCTTGTAAGTTCTAAAGTAAATCCATCGGTAAATGT CACC GGAGCTACAACCATTGAGTATTCCTTGGCATTTTTATTTTGTTCATTAGGACCAACAAAT GTTC CCTCTTTAGCGGTTAGAGTTATAACATTAGAACCGGATTCCACTGTCAGGTTTGCTGAAG CATC AATTTTTACGTTCCCTGCAATCTTTACATCACCACCAGCAGTAAGTTTAATACCTGTAAG GTCA GTAAGATTATTTTTAAACTTAACCAATCCACAAGTATTCTGGAAAGTTAAAGATTTGTTA TTAT CTGTTGCAGTAGCATAAGATATATTTGCATTTGCATCGAATCCCCAAGCCGGAGCTGTCT GTTC AGATGGCAGTGTAGTAGTTACGACACCTTCAAGACACACAGCTTCGGCATTATAAGGATA AAGA GCTGTATATGAATTGTTAGGTGTAGCCTTACCTGTAAACGTTGTAACTGTGCTACCACCT GTAG CGGTAGTAAACTTGTTATTTTCTTGGCCTGAAAAGATATTGATTGCATCTCCTGTTGTCC ACCA CACCGTTGTTCCATTCTGCAACGAACTACGGCTTGAAGGCGTACCGGCAACAAAAGTCAT ATCC TGAGGACCACTGACTGCATTTACATTCGACAGTTCGTCTTTTGTACAAGACTGGAGCATT GCAA TACTCATCAAAGCCGCTCCACAAAATAGCATCGTATTTTTCATGACATAAATTATTTGTT AAAC AGTTTCAATAATAAAAAATCACATCACTTGTTATTCATATTCTTATTCTTTAGGATCAGG TTTC CATTCAGTACCGTCATCTTCAAAATCATCATGACCGCCATCTACAATTCCGGGAGGTATT GATA TTCGGCATACCGCACTTTTTATTCCATTACCCGTATCTACAGAAGCACCGATATTAGAAT CTCT GCCCCCGTCGATTGCCACGACCGTACATCTCATTTTATCGTCCGATGGTGTAATCATCAA CACA TCAGGGAAAGAAGTTCCCCAAACTATTGACTTGTAACCGGTATAAGGGAGATTATCCTTG GTTA TATTAATACCCAACTCCACAGTGCCACTATATGGTAATTCTATATAACTGACAGGTTTGT TGTC AGTCTGCCCATCCTTGAACACTACATATTCAATTTTTATCTCCTCAGCTGGTGTTCCATC ACCT CCACCTACGCCATCATCATCCTTATCACACGAGATTGCCGTAAACTGTATAAAAAGAAGT ATGA AAAGGTTGTATACTGACAGAATCCGTGGTTTTATATCAACCATAATAAAATGTTATTTAA GCGC CAAACAAAATTTTCAATATTCAAAAGGCATAAGAGGAAACCCTGAATATGCCTTATTACC ATGA AAACAAATCAATCTACCTTTTTCAATCCGGAATCAGAAAAATATGTTATTTATTTAGAAC ATAT TTTTCCGATTTGCCAGATTACAATCACAATAAATAAATCAACAACTAAATCTAATTACCT AATC TTATAACTAAACCCTCAAACAATGTTATTTAACCTTTTCTATCTTGACATCATCAAGCAG GAAG CATCCACCATTACCTGAACCCGGAACAGCTGTGAAACGATATACAAAACCATTTTCCTGC AATT TGAATTTAACTGTTGTAAGATTGTAATTCTTACGGTCTTTCTTGACCTCAGCAGTGGCAA TTTC TTCCAGTTTCTTTGAATCCGGATTATAGTACTCAATCCTGAAGTTAGGTTTGTCACCCCA ACTG TATTTGGTATAAGCTGAAATCTGATATTCTGCTCCAGTTTCATAGCTGATGTTTACAGCC TGCC ACATACCAACCTTCACCTCAACAGCATAGTTGCCTGAATGTGCCTTTTTCGCATCAACTA TTTT GTTATCTTTCTTTTCCCAGACATTCCATGATGTCAAGTCACCTGACTCAAAATCACCGTT CTTA ATTTCCTGAGCGTATGCAGAAGTCATCATCATTCCGCAAGCCATCATTGCTAAAATTTCT TTTT TCATTTTTTCTAAGGTTTTTAATTTAAGTATTATGTTGTATCTATTAAAATCACTCTTCT ATTG GAACCAACTTATAAGCCCTGACCCAGTCATAATAAGTAGTACTTTTGTCCTTATCCTTCA AGTC CTCAGCTGTAGGTACTTGTTTTTCCCAATCGTATGTTTCAGTAACTATATGTATGAACAT AGGT CGGTCAAACGGAGTATCTGTATATTTTGTTGTAGGCTTGATAGTGTACATATACTTTCCG TCAT AATAGAATTTCACGGTATTTGCATCCACCCACCAACAACCGTAAGTATGGAAATCTTCTG CCGA TGGGTCCGTCATATACGAAACCACATCCGAACGTTTCGCCGTATTGTCAGTACGTTTGCC TCCT TGTTCCTGATACCAATAGTGAGTATTACTGTTCATCTGCATATTCCATGTCTTGTTCCAC GGAT TATCAGGGTTGACACTTCTTATTATACCCATTGTTTCTATAATATCAAGTTCCTGACTGC TCCA TGTCTTTATCTTCTTGCCGCCTTTCATTATTTCCTTCATTACCGGGCGGTTGGAAAGCCA AAAA GTAGACGACATGGTAGTGAGCGAAGCCTTCATCCTTGTTTCATAATACCCATAATGTGCC TGGT TCTTTGCAGAAGCAACCGCTCCACCGGCAAGACGATATTTATCGCCCGGCTTTCCATCAA GTCC TTCTGTTGGCGACAAAACGGTATTGATTATACGAAGACAACCTTTCTTGACACTAACATT CTCT GCCTTGAAAGTTGCAGGCGGCCGACCGTTAGTCCAATAAGGACTTTTAGCATGCCATTTA GCGG CATTAAGACGTTTACCATTGAATTCATCAGTATAATCTTCGTTAACTACCCATTTATAAC CCTC AGGAGCCTCAGGCAAATTTTTTATATGCTCTTCAGCCAAAGAATATTCCTTATCATTTTT TAAT GTATAAGATGACAGGAATAAAGATGCAGCAGATAAATACAATACTGTTTTTCTCATAAAC TTTG TCGTTTTAGATTTTTTGTTACACGACAAAAGTATATAAGTTTCATGAAAGCATTAAGGGG GATT TACATCGTAAAAGGTGGGGTAAAATTCTACCACTCCCTGAAACACAATTATTTCACTCAT GAAA CCATGTGTTTTTACGATATATAAAACCCGACAGAAGAATAATACCGTATTACCGGCTAAT TTAC ATAAGAATAACTTTTCAAACCGCCATATACCCCACTTTACGTCCGTACCCTCAGTCCTCG ACTC CGGCAATATGTTTTCCATATCGAGATCTATGGTTTTCTGCCTCGGATTCAACCACTAACT GTCG AGCATGTGGATTGCGTATCTGTCATAGAATCTCTTTCCGAACCATATTATCTCGTCTGTG CTAA GTATGTTGTTCAGACGGATAATCTTTCCGGTATTTTACCACCTACTTCTCTTGCAAATCC TGAT CTGATATAACCGGATACTCTCAATTCATTGATTTCCGACTTGTATACAGTCTGCGAAGAG GCAT TGAAACTACTGCACAGACTGAACAGCAGCAGGGGAATAATTTAACTGATTTTAATAGTAG ACAT TCTGTGTTCATAATATTTCATTTTAATGATTACGTTTCTGACTTTCGTCTGATGCAAAAT TATG AGGTATCGGACGGGGTTGTATCTTTCAGTAAAAATCAGTAAAGTCTTGGCAAGGGGTAAA AAAC TTAACATCTTGTATATAAATATATTACAAACAAGGTGCAAAGATTTTCAGTAAACGATGG CGAA TACAGAACCTATATATTTACACGCCATAAAATGAAGAAAAAGCAGTAGGAAAAAAATGCG GGCA AGTTCCGGATAAAATGTGGGCAAGTTTAAGGTAAAACTTGCCCGCATTTTAGATAGAATG CGAT CGCATTTAAAACAAGTAAAAAACGAAGAAAAAAAATATGTGTTCTTCACAGAACACATAT TTCA AAAATAGGTATAAACACGCTAAACAATGTTAACAAAATCTATTTATAAAAAAAGCTCACA TCAA TAATATCTGCAACATTTTTACAATACTCCATAAATGAAGAGACCTTGGGATGATTTATAC ACAG AGCTATCTGTGATGTAGGCGAAAAACGTCCTGTCCCGTCAAGAAACGCTGTAAGCTCAGA TGGG AGGAGTATACTGCCAATACCTGGATTTACGTCAGTCAGAACGACTGTATTTACAGCTTCC ACCG CTGACACATCAAGATAATCGAGTGCCGGAAGATCTGCGAAGTGCAATTTTCCTATCATAT TGCC GCCTTTGCTGCCCTGAAGAGAGACACTCTCCAATGAAGAACAACCGGATATATGGATTTC ACTG TCGAATATTGAAGTTTCGGAAACATCATCATTAAGTATAACAGAAGGAACAACTACCAAT TGAA GCGAACTGTTATTCTCCACCCTAAGTACTTTCAATGATGATGCGGAACTTAAATCCATTC CCAA AGGTGTATCAATATTAGAGATTGAAAATACTGAAACTCCCGAAGACGGCTTGACATACGA CATG GAATAATGCTTGGACTTCACTCCCGAAATGTCTACTTTTCCTCTGAAACCGGGATTTGAC AATA TATACTCCACACCCTCAAGGTTAGCTGTCTGCGACAGGAAAATGAGGTCGTTCCCTTCGG TTAT CCTCTTCGTGACATCAATCTCCAACGATGAGACAAACACCGACGGGAAGTTTCTGTAAAG ATAT GAACGGAGCAAAGGATCCGGTACTCTTCGGTTTACTGTATATTCAGTGTAATTTCCATCC TCGT CCGACATCACGACAAGACATTTGTCCGTCATGGCTTTATAGAATGCAGGTATGACATCTG TATT CCATTTTGCAAAGTAAGGAAGTTTCAGATTTGTAAGACTTTTACAAAGCACCGTAGTGCC ATCG GTTGAAATAAGATTGAGATACGAAGTTATGCCGTCATTGCCGCGTAAAGCTACCGATTTT ATTC CTTCGGGCAGGTCAGCAAAGTCGAATATAGAAAAACTGTTACACTCAAGATTGACATCTG CGAG CGAAGGAAAACTCCTCAAACCGCTAATAGATGTAAGTTCGCATCTACTCAAGTCCAAAGA AGTG GTATTGAGAACTTGATTGTCACAAATCAGCTCTCCGTTTTCGCTGAAATTAAATCCTTTC CGGG TCAAGACATCGCGTAACTTTGTATCAAAAGTCACTTCAGACACTTCAAAGTCGGAAATTT CTGT TTCATCCTTACACGAGATTATTGTGAAACAGAGAACTATCAGTACATAAAAGCTAATAAA ATTC CTCATAACAATCAGTTTTGTGGTAATAAGACTATATTATCAATCCAAGCCGCGTCGTTCT GTCT TTCGCACACAATGGCACACACTACTTTTTTCACTGTAGAATTAAAATCGAAAGATACGGC TTTA TAATTGCCGGGAGAAGAAAATTCCTCTGTATATACCGTTCCTGTAGACATATCCTGTAGC ATGA CTTTCAACTTACATGCTCCTTCGGTCTTTACATCAGCAGAGAAGCGATAAGTCCTGCCAC TCTC CATGTCAACCCTCTGCATGAGTCCTGCATGACCAGATATACAGGCTACATTATTGCCTGC ATTG TCAGTCTGTACGCAAACCGTACCATAGTTACCCAATGGCTGCCATGCTGAAAGTCCTTCG CTGA AGGTTCCATTCTGCAAGGTAGAGACAGTATATTTCTCAACCTGCAGTATCATGGACGATA CGTG ACCTCCTCCGTCGGAAAAGGTGATGTCGACATTATTATCGCCATTCTTCAGCAGCTGTAT GTCG AACGGTACTTCTATCATACCGAAAAATATATTGCGGTTGCTCTGGCCGTAGCCTTTCCAG TTGT CGGGAACACTCACAGCGGTACCATTAATCTTTACCACCGGTTTCTTGGAAGCAGAGACAG GACG GCCTATCGACATACGCAAGCTTGCTCTGCCCGAACCGGACTCGATTCCTGTGAAGGGGAA CGAA AGGGATGATCCGGCGGAAATCGGTTTCAGATACTCACTGCTGTAATATTTATTGCGGATT ATGG AGTTCGTGAATGCTGACGAAGACACATCTGCTACAAGGACTATGGTCTGATTTGGGACAA TTGA GATGCTTTCAGGCATGGACGGGACATTCTGTTCCGTATATTCTATACCTGCGTTATAATT GACA TATAGAGAACGCTTTGTGACATTCGATACATCCTTCCAGCTATTCTTATTGTTCAGATAT ACAG TCTGCGGGTTATCATCAAGATTATCAAGGGCGATATAGAGTCTGCCTCCATCCTTGAATG CCTG TACCTGAATATCAGGATTACTGCTGGTTATATCAACACGTTCGCCTTTTACATTCTTCCA GAGT TCGAAGAAATATTTTTTGTCATTAAGCCTCCATGTGGTATTCTTCAGATTCTGAGGATTG TCGG GAATAAACAGTGCCGCACTATATGAAGTATAATTGTTTGCAGCGGTGATATGCCACTCAG CCTT ATCTGAGACAAAAGGTATTGAGATAAACAAATTGTCCTGACGTTCCATCAGATTAAACAG AAAA TGATTAAACGACGAAACACTCCGCACACTGCTTATGTCATCATAGCTGTCGTCGGGCTTG CTGT TGTCAATACCTCCAAACTCGGAAATGGCAAGAGGCTTGACATGTCCGAACTTAATATAGG AATA CGCCTCAACCATATCAAGAACTGCTTCGGAGTTACTTCCTGAACGTTTCGTATCGGTGCC GGTT ACATTTATTCCATCATAAAGATGTACAGAGAATCCATCCATATATGCACCTGCCCGATCG ATGA ACATTTTCATGCGGGTGTTCCAGTAATTGAAGTTCCCATCCTCCCAGGCGGGGTAGGCTG CGGC ATAGCCTATCACCTTCATCTTTCCGTTAAGACGCGGATTATTGTGTATATGTTTACCTAT TGAA GCATAAAAATCGACCATCAGTTCGCGCATAGCCTGTCCCTGAACGGTAAAACCGGCATCA TTTG CATGAACGAACGGTTCATTGAGGGGTTCAAAAAACTCAGGTACCAGCTCGCTGTTGGAAT AATA CTCAGCCGACCATGCACCTGCAGCCTGAACGTCTATGCCGCCCTGTATGTGCTGTACATA GGGA TGCTCTGTGGCAATATATCTTTTTACGGAAATATTTCCGCTGTATGGTTTCATCTGAGGA TATT TGCCTACCTCATGCGTCTTGTTATACGCATACGAGTATGGTCCCCAGAACTTTCTTCCAA GACC GACCTGATAGTCGGCAAGAAACTTGCCTACATCCTTATCATCATCGGAGGTGGAATGAAT ATTG AAATATTTAGAACGGTCGAGTTCTGAAACACCGCTCAAAAAGCGACGGGTATTATAGTCG ACAA CCACCTCGTTCCTTTCCTGACAATAAATACCGGGAGGAACACCTAGGGTAAATGCCGATA ACAG AAAAATATATTTATAGCTCATAATTTCTTTCCTTTTAGACACAGAAACTTGTCAGTCCTG ATGT GGATACATTATTTTCTCACTTTCTTATCGTAGCGTTCAGTCTGAAGAATCATAGTAGCCA CACG GCCTCCATTATCCGGGAATGTTACTGACACCGAATTTTTTCCTTTTCTGATTAACCGGTA GTCG AAAGGTATTTCTATCATACCGAAGAAATCGTCTCTGCCGGTCTGGTCATATCCTCTCCAA TTGT CGGGCATGTCGACTTTCTTGCCATTAACCATTATTTCAGGTTTCTTCGACATCTCGTGCT TCCT GCCTATTGACATACGCAGAACAGCTCTTCCTGTACCCGGTTTCAGACCATCGAAATCAAA CACA ATTGGTTTTCCGGCTTCCACCGGCTGAAGATAAGTGTTGCTATAATATTTAGTACGAACT ATTC TGTTTGAATACTTTTTACGGATGATGTCGGCACACAATATTATTGTCTCATCTTTTATAA TGTC AATACTTTGAGGCATCGAGTTCAGCGTCTTTTCATCATAAACTATACCTTTATCGAAAAT CATC TTCAAAGAGCGCACAGAAACATTATCTACACCCTTCCAATTCAGTACGTTTTTCAAGTTT ACCT TATGTGTATAGTCATCAAGATTGTCGACAGCTATGTAAAGCCTGTCATCGTCCTTAAAAG CTGC CACCTGTATGTCCGGATTGTCGGAAACAATATCTACACGTTCGCCTTTCACATCCTTCCA TAAC TTGAAGAAATATTTCTTGTCGTTCAGTTTCCATGCGGTATTCTTCAAGTCGTGAGGATTG TTGG CAACAAATAAAGCAGCTCCGTATGGTTCGAAATTATATTGTTTCGTTATATGCCATTCGG CCTT GTCAGAAACAAAGGGTATTGAGATGAGCATCTTGTCTTCGCGTTCAAGAAGATTGAACAG TATA TGATTGAACGAAGCGACAGTTCGTACAGAGGCTATCGGATTATATCCTTTGGAAGTGTTG TCTA TTCCTCCATATTCGGTTACGGCAAGAGGAAGAACTTTCCCCAAGCGGATGAACGAGTAGT TTTC CATAAGGTCGAGAATAGCTTCGGAATTACTTCCCGAACGGCGGGAACTCTTGCCTACTAT GTTT ATTCCATCGTAAAGATGTACCGACAAGCCATCCATGTACTCCCCGGCACGGTCAATGAAC ATCT TCATAGTATTATTCCAATGGTCGAAATCGCGCAACTCCATAGCCGGATATGCCGCGGCAT ATCC AATGATTTTCATTTTTTTCAGACTTGGCTCAGCGTGAATATGCTTTCCTGTCTGTGCATA AAAA TCTGCCATGAGCATCCTCATTTCCTGACCATGCATATTGAAACATTTGTCGCGTGCATGG ACAA AGGGTTCGTTAATGGGTTCGAAAAATTCAGGAACTGCCCCTTTCACATGCTTGGAATAGT ATTC GGCAGCCCATGCACCCGCCTTCACTGGGTCTATGCCCCATTGTATGGTACGCGCGTTGGC ATGT TCCGTAGCGACATATCGTTTTGTTTCCTTCAAATCAGTGTAGTTCAAAGGCTTTTCTGAA AAAG GATATTCGCCAACCTTTTTTGTCTTGCCATATGAATAAGAGAACGGTCCCCAGAAAGAGC GGCC GATTCCTACACCGTAATCTGCAAGAAATTTCCTGACATCTGGATCAGAATCTTTAGATGT GTGT ATATTGAAATATTTACCTCTGTCAAGTGCCGATACATCATTCAGGTATCTCTGAGTGGCA TAAT CCACTGTGACAGTAGTGTTATAAGTCTTATTCTCGGAAGATGATAAAGGAAAAACCGAGA AAGA CAAACACACAGACAAAGCTGTAAGAATTATGTTATTCATTGTATTATCAAAATTTAAAAG GCAG AGAACACTCCGATAGTTCAATTAAAGTATTCCCTGCCATTAAGATTATCACTTCTGTTTA AACA CTAATATCAGAAATCGGCCGGTTTGAGTACATCGTTCAGCACCACTTCATATTCAACTTC TGTT CCGTCGTTTTCAGTAACAGTAAGATGGCCGTAACCGCCACTTGAGTTATTTTCTTTCTTA CCTT CAAACATGAACATTCTCTTCTTCGTCACTTCCTGTTCTTCTTTATCGCCTGTTTCAGGAT TGAT AACTTCTTCCTTTTCAGTATAGACTTCATTGAAAGAGAATGAGAGATGTTTTTCTGTATC CGAA TTGATTTTCAGCCACTCGGGCAATTCCGAAGGAGCCTCAGACGACTCGGCAAAGAACTCG ATCT TATTCATTCTCAAAGTCTGATAGTCATTCTTCCAGGCAATGAGGTCGAACAATTCGCGAT AAAC AGAAAACTTGGAAACCTCGCCTGTCTTTCCTGTTTCCACATTCTTGAGATAGGTAAGTTC ATAC ACGGGAGTAGAATCAAGTTCGACCTCAGCCCATTTGTCATTATCACATGCTCCGAACAAA ACCA AAGCACATAAGAATGTAATTGTCTTATAAATTTTATCTATTAGCTTCATTGTTACTATAA TTTA TTATGGTCTTACTTCAATATATCCGAAAAATATATCGTCAAAATAAATATTATCCTTAAA GGCA TTAAAGCGCATACTGAGCAATATATTGTCCATTTCAGCCTTTGAAGTCACAGTGGTTGTG GCCG ACATCCATTTGCTGTCGGAGCCATTCACAATGCCGCACCATGGTCTATCGCTCTGCCATG TCAT ATCTTCAGCTCCTTCTTTACCTGCCGGAACGAAATACGGACTCATACCCTTACCCTGTTT ATAC CCCGGTGTATAATATTTGTAGCTGAAAGTATATGTACCTTTACCACCAGTAAATGTCTTG GAGA GTAATGCCCTGCATCGGTCAAATGCTTCGACAAACATACATTTTGCACTGTTGTTTATTC CATC CTTCAGAGGATTGTCCACAACCTGTGAAGGAACTACAGGATGTGTTTTGGTATCGGCATC AATA ACTTTCCAGTCGGCATATGTGTCAGAATTTTCAAAATCTTCATCCAGGAACGCACCAAAA GTAG TCGCTACGTTTGGAGCTGTAGCCTTTATCTCAAGGTTCTGATATCCAACCAACGCTTCAG TTAA AGTTCCTGTAAGGGTCAGTTCATCTGTGTTATAGATTTTCTCAACCAAAGTAAGAATCAG TTCA TATCTGCTTTGCTTGTTTACTTCTGCTGCTGTGATGTTTACGCTACCCCTGACAGCTGAC GGTC TGTTATACGAGTTGGAGTAAGTAAGCTTTAGAGATGATGGATTTATCTCTTTATATCCAA ACTC AGAATTATCCAAATCTATAGCAATGTGTGTTTGGTCAATCTGACGGATGTTATAAGTAAT AGGA TCATCACTAGGTACTACTGTAATAGCCAAAGGCACAACAAGAGTTTTTGGCGAAGCTTTT GGAG TGTACTTACCTTTACCCTCACTGGCAGAAGTTCTTTCTATTGTCATGGAAAGAAGCAATG GCTT ATCGCTGAATTTCTTTGCAGTGAACTGGTATGGAGTGTCAAAACTGGTTAATTCGTCATT TACG CCAGTATCCGCACATTTGAAAGTCCATTTGTTAGGCAATCCGTATGAATCGTCCTTAATA TAGA CAGACTTACCATATTCAAGTTCGTATTTTTCGTATTCGGGAGCTTCCTCAGTTCCACCGA CTAT TCCGGTCTTTATTTCCTGTGTACACTCCGGATCACTGTATACCTTTACGGCCGGTACGAG GTTA GGATCATACACGCGGATATGGAAAGTTGTATCCATCACATATACATCACCCTCCTGCTTA GCAT AACAATATTTTTTGATATATCCTCCGGTATTGTCGTCATACACCGAATATGGATATACAA CCTG TCTGCGGAAAGTATTGCACAAACGTACCGTATGGTCACCGGGTTTAGTGAAATACACATG TATG GTTTTCAAATCGTTGGTATGAGGGATGGATTCATCAATCAGGTTTGTATAGTCTGTCTGT CCCC ACTCCATCTTACCATTAAGGAACTTTGTACCATCATCCGACACAACCCACTGATGCGACA ACAT GCCTTGGGATAAGTCCATTATACTTATATAGTTATTAAGATTCAGCTGAATAGGTGAAAC GTTT TCCTGATCTGTACTCACATGCCAGGTACATTCAGCCACGTTATTCAACGGTTCAAACTCA TCAT CCTTACAAGATGTCAGAACCGAGATTAATGAAAGAGCAATATATAAAAATCTATTTTTCA TCGT ATTTATTTATTAATATCAGGATTTGATGTAATTTCTATATTTGGAATAGGCCAGTATGCC ACTT GCGGACCGTAGTTCAATGATGCTTGGAAATAATCCACAAAAGCGTTTCCTCTCTTTTCTG GCGG CAGCTCATAAAATCTGTACTGCTTTCCAAAGTTGAATGCTGATACCAAAGCATTAGGGTC ATCA GGATTAGGCTTAAGATATTTGGTCTGAATCATACAGTACTTATATTCGTCGGATGCCAAC TGAT CAAACCTTTCCTTAGTTATATTCCAGCGTCTCAAATCAATGACACGTATGGCATGTCCTT CCAT ACACAGTTCAAGAGGACGTTCCACATACATCAGATGATTCATTACATCACTTGCAGCATA TTCC TTCTCATCGTATGTATATCTCTTGAATTCTCCCTGTTCCGATTTTCCGATAAGCACAACT CCAG CACGGTGACGTACCTTGTTGATGGCATTGATAGCTGACTGAACATTTCCATCGCTTGCAC CGCC TTTAATCAGACATTCTGCATACATCAGATATATATCTGCCAAACGGATAAGACGATAGTT TATT CCTGAGGCCATAGCAGGCTTAAATTCAGTTTCACTCTTACGTGTATCCCAATTTGATAAT TTTC TGAAATACGCTGAAGAGCCACGGTTGAATTTTGATACCTGTTGTGGGAGAGACTGATAAT ATAT CAGACTTTCATCGCCGTTTATTGCAAGAGAGGCAGATGCACGCATGGAATAGCTTCTGAG GCGA TATGCCTGACCGTCTTCCCATTTAAATTCCGGAACTATGTCATCGTAGCCGGTAATCTTA TTGT ATAAAACTTTATTATCTCCGACAGTTGAGACGAGTCGTTCGCGTACTCCAACATATTTTC CTGC TGTTGCATCCCACGTATAAACGTACGTTCTGTTATATACGACACCCTGACGGTCCACCTG CGAG CTGAAAGTTGTTCCCAACTGGTCGTATATAATATCCCTATGTTCAGGATCACCATAATTG TCGG ACTGCATTTTTATCCAGTTACGTTCATCAAGTCTGTCCACCGGCTCTGTTTCGAATGCTT CAAC AAGCCAAAAAGCAGGAACAGTGTTAAGCCAGGCATCGCCCAAGCCATTTACATTCATTCC CCAT ATATTATATAAGGTAGACTCCGACCATGTACCGAATTCTGTATTATACTGTGTAGAATAG GAAA CCTCGAGAATAGATTCCGAATTGAATTCATTGGCAGCAGTAAAATTATCGACTATGTCAT CAAC CAAAGCAAAACCTCCATTATCAATAATATCCTTAAAATATTCGGCAGCTTTATTATACTC TTTA TCATAAAGGTAGCTTTTGCCTAATATTGCCTTTACAGCCCAAGAGGTGATACGTCCCAAA TCGG TTTTCTCCCATTTGTCATTCAAGCCAAGGTCAAGAGCTTTCTGTAAATCTTCTCTGTAAT ATTT CTTGATTTCATCACTTGGTGTAACCTTTTTATAGTAATCTTCTTCTACCTCTGCAATTTC ATTA ATATAAGGAACATTACCATTATTGAATGAATTATTGAGATAAAAATAAAACAAGCCACGC AAAG AATATGCCTGTGCCTCAATCTGAGCAAGCTTGGTTATTTGAGGTTCATCTGTAACATTTG GACG GATTTTCTCTATACTGGCCAGAACCTGATTCGCACGGAACACACCAGTATACAGTGCAGA CCAT TTACCACGGACTGTTCCGTATGAATCATTAAAGGTTTGCTTATAGGCTTCGTTATCAAAC TGCT TTCTGTCCTTATTACCTTCAACTGCTATATCACTTCTACGGTTCTCATCGAGCGGATGAT AAAT ATTGGTATTTTTCAAAGCATTATATACAGCAGCCAGTCCTTTCTCGCAGTCGCCTATTGT TTTA TAAAAATTCTGTGTTGTCAGCTGATGTATGTTTTCCTGCGTAAGGAAATCGTCGCATGAA ACCA ATGTCATGCCCGACATCAACAGACTGAATACTATTGTTTTATATCTGAAGTTCATATATT TATA TTATTAAAAGTTAGAAATTAATCTGGAATCCGCCACGCATCTGGATACTTATAGGATATG TTCC ATAGTCCAAACCACGACGTGACAATCCATTACTACCGACCTCAGGGTCGTATCCGTCGTA TTTT GTCAGTGTAAGAAGATTATCGGCTGCAACGTATAAACGGAACTTGCCCAATCCAAGCTTT GATA CCCAACTCTTGGGGAATGAATATCCTAACATAATATTTTTAAGTCTGACAAATGAACCGT CCTC AATCCACATATCAGTATGAGCACGATAGTTGTTATGCCCCTCTGTACGATAAGAAGGAAT GGTA GAGGTATAGTTGGTAGGGGTCCACATGTATATCAGTTCCTTATTGGTTCTTCTTTGATAT GTAT ATATCTTCGTACCGTTTATTATTTCATTTCCAACTGAAGCATACCAGTTCATAGAGAAAT CGAA GCCTCTATAGTCGGCCGAGAAGTTCAAACCAAGTTCATAATCCGGCATACCACTACCGGC ATAA ACACGGTCGTCATCATTAAGAACACCATCATTATTGGTATCGATATACATAAGGTCACCC ATAC GGGCACTTGACTGTAATTTCTGATATTCTGCAAGCTTCTGTTCAGTATTGATTACCCCTG CGGT TGGCATAACAAAGAAAGCACCGGCTTCATATCCTTTCTTGATTGCAGTTACATAATCACT TCCT GATGAAACAGGTTTACCGTCGGGGAAGAAATATAACTCATTTTTTCCTGCCATAGACACA ATCT CATTCACGTTTTTGGTAAATGTACCAGTCAAGCTGTAATTAACACCACGTATTTTGTTGC GGTG AGTAAGTGAAAACTCAACACCACGGTTTTCCATATCTCCGGCATTCAATGTAACAGTTGA ACTC TGGCCCCCTCCATTTGACGGTGGCACGACCATCGGGAAAAGCATATTCTTCTTGTTACTC TTGT ACAAATCAAGACCTAAGATAAGCTTGTTATTATATAAAGCCATGTCGATACCGGCATTAA GCTG CTGGGTTGTTTCCCATTTCACATTCGGATTGGCAAATCCCAATTGGGTAAAACCATTTGC AAGA ATTTCGGAAGTTCCGGTACCAAAAGTATAGTCGTAGTTTTTGTATATAGCTGGTGCGTAT GAAT AATCAGGGAAGTTCTGATTACCGGTAGTACCATAGCTGAATCTTAATTTTAACGAATTTA CTAG CCACCTGAATCTGTCGAAGAATGATTCCTCAGAAATATTCCATCCTACAGACAATGACGG GAAC AATCCCCAACGATTTTCTTCGGAGAACTTAGATGAACCGTCGCGCCTGATACTGGCACTT GCCA TGTATTTGTCTGCATAGCTATATTGTAGACGACCCAACATACCAACCATTGTACTGATAC GGTC CTGTCCCCACTGGCCACTGCCTGTACCCACAGTCATATCGGATGTTCCCGCATTTAGGTT CGGA ATCTCGTTAGTAACCAAATCCATTATACTGGCATAGAACATCTCGTATGTATATTTCTCC ATAC TGAAAACTCCGGTAAATTTAATATCATGCTTTTTTATCTTCTTATTATAATTTACCATTG TTTC CCAAGTGAGACTGGTATTCTTTGAATGAGTATCTTTTAATTGCGAACGGTAATTAGAGCT GGTT ACCTTTTCGCCTTTCTGATTATATACCTCAAACTCAGGTCGAATTGAGACAGCTTTCTGA TTGT TATATCCAAAGCCCAAACGTGTGGAAACATTCAGTCCGGGAATTACATTATAAGCAAGAT AAAA ATTACCGTTAAATGATTCTGTGTCCTTATGATTTTCCTCTTTCAATCTTCCCAATGTATA ACTT ACGCCCTGTAAATCTGCAGGATCGCCAGCTGCATTTACTATACTTGCCTGTGGATAAATC TGAG AACGAGTAGGCGAGTAGTCATAACATTCGTTCAATAACCCCCAAGCCGGAGATAACTGGT TTTC TATCTTCATAGCGATGTTAGTGTTGATAGTCCATTTTCCGCGCTGAAAATGTGTATTCGA ACGA ATATTATATCTTTTGTAATCGGAATTTATCAACACACCTTTCTGGTCGAAATAGTTCGCG GTAA GGTTATATGTCAAATCTTTCTTGCCGCCATTCGCAGTAACAGAATAATTCTGTATTGGTG CGTT ATTATTGACTACATATTCATATAAACTAGAGTTGTTGAAGAAATTCACAGGATATGTTTT CAGA TTAGACCAGGCCAGGTCGTCTGTATTCTGGTTTCCTTCCATCATTCTGTTAGACATCACT TTTA CAAATATACTCTCGTTGGCATCAAGCAAATGAATATTCGAAGTAATGTGCTGTACACCAT AATA TCCGTCGACAGCTATCTTCATTTCTCCTTCCTTACCCTTCTTTGTGGTAATAAGGATAAC ACCG GAAGCACCGCGAGTACCATAAATGGCAGCCGAAGCAGCATCCTTAAGAATATCTATACTT GCTA TTTCGCTACTACTCAATCCCGGGTCGCCCTCGAACGGGACACCATCGACAACATATAAAG GAGA ACTGTCGCCTGAGATAGAACTTAAACCACGAATCTGGATGTTGGATTTGGCTCCAGGCTC ACCA GAACTTGCCTGAACGTTAACTCCGGCAACCATACCCTGAAGAGCTGTACCCAAGTCGGAA GTAC TGATCTTAGTAATCTCATCTGAGTTTACACGTGCCACTGCACCTGTCACCTCTTTTTTAC GCAT TGAGCCATAACCTACAACAACCACTTCATCCAACACTTTTGTGTCTTCCTGAAGCTTGAT ATTA TAAATCTGACCATTCTTGATTGCAGCTTTTACAGTTTTATACCCAACAAAACTGAACACT AAGT TACCTTTAGTCGGTACCCCTTGAAGAACGAAATTACCATCCATATCAGTAATAGTTCCAA GAGA AGTACCTTCAACTTGAACAGCTGCGCCTATAACTTCAAGGTTATTGGCAGCATCAATCAC CTTT CCTTTAACTGTTATCTTCTGTGAATACATAGACAATGTATAGAAGATAAGCATCACGAAC AACA TGTACCTGCCATGGTACCATTTTTTCTGATTTCTCATTTGTAAAAATTTTAATTTAGCAA TAGG TTATGAAATTCCTTTTATAACTGACGCTAAATTATTTATTTATAATGGTACAAAAGGGGA GAAT TATATATTTAAAAAGGGGGTAAAATTTTACCCCCACTTATATTAAGAATCCAAATCGGTC TGTA TACTCTGTTCTTTGTACTGTTGCGGCAATACACCGAATTCTTTCTTGAAACATTCTCTGA AATA CTTCAAATCATTGAACCCTACATCGTATGTCACCTCTGATACAGAATACCGTCCTGTCTT CAAC AGTTCTGCCGCTCTCTTCATTCTTATTGAACGTACAAAAGCATTGGCTGTTACTCCCATA AGTG CTTTCAGCTTCTTGTTCAGAACCAAGGCCGTCACGCCAAGACCTTTACATATATCCTCTA TCTG GAACGAAGAGTCTGTAATGTTGTCCTCTATTATCTTTACAAGTTTCTCAAGGAACTTATC GTCG GTAGATGTAGTGCTTACCTCGGAAATCTTTATTGCCGGAACTTTCTTGTGTTGAAGAATC CGCT TCCTGTTGGTTATAATGGAATTAAGCAGCTCTTTCATTATCTTGTTGTCGAAAGGTTTAG GGCA ATAAGCATCTGCATGGAATTTATATCCGATGAAATAATCCTGCAATGTAGTCTTGGCTGA AAGC AATACTACAGGAATATGAGATGTCCTTACATCCTGCTTGATTCTCTCACACAGTTCCAGA CCAT TCATGCCCGGCATCATTATATCGGATAAAACAAGATCCGGTTGCAAATCTGGAATCATGT TCCA TGCCATCTCCCCATCATGGGCTATCATTATCTTATACTTATCCGACAACAGTAATGACAA CATA TTACATATATCCTTATTGTCATCAACAATCAATATAGCCGGAGATTCTCCGTCCACTTCT ATGT CTATCATCTCTTCATGCTCGCACGATTCACTTCTTAACACATCAGCAAACTTTTCATCCT CCCC ACTGTTGGCAGAGATATTCTCCGTAACCATGTCCCCCTCAGTTATCATAGGAATTACAAC ATGG AAAACAGTGCCTTTACCTTCCTCTGATACAAACGTAATATTTCCATTATGTATCTCTACA AGCC GCTTGGTCAGAAACAGACCTATACCGGTACCTCCTTCAGCAGAGTTTTTATTCTGACTGT AGAA ACGCTCGAAGAGGTGTGTTTTCAGGTTGTCGGATATTCCGTTTCCCGAGTCTGCCACAGA GATG TTTATTTTGTTATCCTGTTCATTGACAGTAAACGATACAAATCCTCCGGCAGGAGTATGC TTAA TGGCATTCGATACGAGATTATAGATTATCTGTTCCATAAGATGAGGGTCGAACAGAAAGC TTAT ATCACTGCGTGAGACAGAATATTCCAGCCCTACACCTTTCTGTTTTGCCCAATACGTGAA CTGC TGAAATACTTCTTTTGAGAAAGACGAGAAGTTGCCATATTTGAGATTCAGACTAAGCATT CCTT TCTCGCTCTTTGAGAAGTTCATCAGCTGGTTGACAAGACTTAACAGGAACTTACTGTTAT GCTC CATTGTCTGCAGCATGCCGGCAAGATACTTGTCGGACGAATACTTGCCCGATTCAATAAT CATA CTAAGTGGAGAATGAATAAGTGTGAGTGGTGTCCTCAATTCATGCGATATGTTGGTAAAA AATG TAGTCTCCTTTTCAAGAAGTTCTTCAGTCTTGCGTTTTTCCATGTTTGCTATATATAGAG CATT TCTGCGCTGCACCCGTGAGGTATAATACACCTTGAACCGGTATAAAGACAAGACAAGCAA TATA AAATAGAGTGTATAGGCATACCATGTACGCCAGAAAGGAGGGTTAATAATGACAGGTATG GAAA GTTCATTCAAACTGTAGACTCCATCGCTATTCCTGACCCTCAGTCTGAACATATATTCGC CTGA AGGAAGCTTTGTGTAGAAAGCCTCACGATGAAAAGCGGAGGTGGAAATCCATGAATCATC TACG CCTTCGAGCATATATTCGTAACCAACCTTATAAGGACTTCTGTAATCCAGGGAGCTGAAC TGGA ATGAGAAAGTGTTTAAATTATAAGGCAATTCAATGTGCTCTGTAAAACTTACACTTTTGT CGAA ATAAGCTGAATATGTGGAATCTGCCTCAACGCTGTGATTGAAGATTTTAAAATCAACGAG TGTA GGACTACCGTTGAAATCTATCACATCAAAGTCATTAGGTCTAAAGACGTTAATTCCGTTT ACGC CACCGAATATCATTGTTCCATCCGTCATTACTCCAGCAGAAAGTTCCATAAATTCATAAT CCTG AAGACCATCGAAAATATCATAAGATCTTATTCTCTGTGTGTTGATATTCAACGAATTAAT TCCT TTATTGGTAGAAATCCATAATGTTCCATCCGTGCCATTAACAATTGATTTTATTGTATTG CTGC TCAACCCGTCTGCAGAGCTAAAATTTTCAACGCAGGCATTATGGTTTTCATCCAAATCCA CGAT TTTCCTTAACCCACGTCCAAGTGTTCCATACCAGATATTATGATTCAAGTCTTCACATAC AGGC ACTATATAGTCGAGTTCATCAAGTCCCTTGACTGAGTTCAAAACAGGATTATCTATATAC AAAT CTGCAGATTCCAATACTTTAAGACCGAAGCTGGAAGCTACCCATATATTACCCTTATGAT CTTT AATGATGTTTCTTACTATCTTAAGTTCTTTATTGTCAGATGTTTTGATTTCCTTCATCAC ACCT GTGGACAAATCATATCTGAAAAGACCTTTATTATATGTGCCAATCCACAAATATTTTCCA TCGG CAAGCATTGCGCGCACATTTCTCAAACCTGAGATCTTTTTATAATCATTATCAGAAGTGA AACT GTAAATACCATCGTACATCAGAGACACATACATGCAGTCGGTGTAGTTTGAGTATGCTGT TGAG TATACTATCCTGTTTGCCGTGAAAGGAATAAGTCTGGCATTACCGGTAATGGAATTAAAA TGAT ATAGCCCTGAGCCTTCTGTGCCTAAATATATATCAGATTTGGCAAATGTATAAACGGACG ATAT ATGATCATTTCCTATTCCTCTGAATAAATCTATAGGTTTATTATTTTCGCGTATACTCAT AAAG CCACTCTTGAAAAATCCTATCCAAAGAATATCGTTTTTATCAAGAACTACAGTTTGCGGA TAGC TGTAAGAATATGTAGCAATAACCTGTGGTTTTGACTCGATGGCATGCAATACATCAAAAG TCAA CACATTCACAGTGCTTGTAGTGGCATAAAATAATCTTTTGTTTTTATATACCATTTTTCG TATA TCACAGTTTTCCAACAGGGTACTTACCTTGCAGGTATGCTTGTCGTATAAACATAATTGA TGAT TTTCCAGATTTGAGTACAATATTTGAGAAGATGAGATGACTATGGCTGAAGCTATAGGGC ATCC CAATAGTTTGTTAAGCAGTAATTCATCTCCATCGACGTTACATTCGTACAGGCCGTCTTC GGAG GAGAGCATTATCGTATTATCTATTTCTATGATGTCGGAAATGTATGGTAATTTTAATGTT GATC TTAAGACAGTATTTATTTTGCCATTTTGAAAATCATAATTTACAAGGTATATACTTTCAT CAGA GGAATGAAACCAGACTCTGTCTTTAGAGTCGACAAGAATCTTATCGCAAGTGAAATTTTT ATCA ATACCGCTGTGACCAAGATTTAATGAAACGAATTCGTTCTTTACAGAATTGAACAGGAAC ACTC CTCTATCGGCTGTACCTATCCACAGATTTCCATGTGAATCTTCGTCAATACATACTATCA GATT ACTGTTAAGACCGTTTGACTGATATCCGTAAACCTTAAATTCATATCCGTCAAACCTGTT CAGT CCGTCGTTCGTGGCCAACCATATAAAGCCTTTTGAGTCTTGATAAATACATTGCACATCA TTTT GGGAAAGTCCATCAAGAGTAGTGTACTTTCTTGTGACAAACTCATTGGATGCAAAGGATT TGCA AACTATAATCAGAACTGATATTAAACTTAAGATTAATCTAAACATATAACTATTATTCTT TATA TTTCATCAAGATTACAAAGTTATTGATTTTATCTAAAACATCAAGTATTTACAGTAGTTA ATAG ATAATTATAGATATTTTCCACTTTAGAATGCGTATCAAAATCAATCAAGAAAAAAATAAA TCTT TAACTTCATTTCATAGTATAAAACAAAAAAAGCATCGTACCATTACACTCAATAATAGAT ACGA TGCCCGAAAGAAATTACAGTAACAGACTGTATTGGGATTGTTCTTAAAAAGACTTATCTG TATG ACTTTATATATATGTCGAGTATTTCGGTATCCGACAGTTCATGAGGGTCCAGACTGAACA ATGC ACCCATGGCAGTTCGCGCATTATCAATCATCTTAGGGAAATCTTCCTTTACTATTCCCCA GTCG CTAAGCTTCAAATCGCGGACATTGCATTCCTTCTGCATTCTCACCAAAGCATCTATAAAA TGTT CGGGATTAAGGTTCTTGCATCCGGTCATAACATCTGCCATGCGCATATATCTCTTTGTCC TGTC ATAAATAAAAGTAGAGAAATAGGCCTCGCTTATAGCTATCAGGCCAACACCATGAGGAAG AGCG GGATAGTATGCGCTGAGAGCGTGCTCGAGAGAATGTTCGGAAGTACAACTGGATGTGGAT TCAA CCATTCCCGCCAGCGTACTTGCCCAAGCCACCTTTGCCCTCGCTTTCAGGTTATTTCCAT CCTT CACCGCAACAGGTAAATATTTATACAGCAGTCTGATGGCCTCAAGAGCGAAAATATCACT TATT GGGGTTGCACAATTGGCAATATAGCCTTCGGCTGCATGAAAGAATGCGTCGAATCCCTGA TAGG CAGTCAGATGTGGCGGAACTGAAACCATCAGTTCCGGGTCGATTATCGACAGACATGGGA AAGT TAAAGTGGAGCCGATACCTATCTTTTCGTTTGTTTCCAGATTGGTTATGACAGTCCATGG GTCA GCCTCGGTTCCGGTTCCGGCTGTTGTAGGAATGGCTATGATGGGCAATGCTTTGCTGTAA GGAA GCCCCTTGCCGGTACCTCCTTCAACATATTCCCAATAATCGCCATCATTACATGCCATGA TTGC AATGGATTTGGCCGTATCTATCGAACTTCCGCCTCCCAAACCTATAATCATATCGCAATT TTCC TCACGACAGATTGCCGTACCTTCCATTACATGGTCTTTTATTGGGTTAGGCAATATCTTG TCGT ACACCACGGCATCAACATTATTTTCTTTCAGCAGACCAATCACCTTATCCAGATAACCAT ATTT ACGCATTGATGTTCCGGATGAAATGACTATCAAAGCCTTTTTGCCGGGCAATGTCTCTGT TGAA AGACGTTTAAGTTCGCCACATCCGAAGAGAATCTTCGTCGGAATATTATAACCAAAAACA AAAT TATTGTCCATAAATATTATCAGTCAGTCAACTTACTATCTTAAAGCCTCATCAATCACTT TCTT GAGTTCAGGATAAGCCTCATCTGTATCGCCCACCTGTTTTCTCAACTCACGCAGTTTCTT TTTC ATGTCCTTAAGAACTTTGGCGTATTTAGGATTATCAGCCAGGTTTACCATTTCGTAAGGG TCGT TCTTCACATCGTAGAGTTCGAAAGAAACCGGAGTAGGAACAATCTTGTGGCTGTTCTTCA ACCA TGACATTGATTTCTGTCCGTAACGTTTGTCGTCGTAATGACGGCCATAGAAAAGTATCAG CTTA TAGTTTTCCGTGCGGATACCTATGTGTGCCGGAACGTCGTGATGAATCATGTGCATCCAG TATC TGTAGTAAACAGCATCCTTCCAGTTTTCTGGCTTTTTGCCTTCGAACACAGAGGCAAAGC TCTT TCCATCCATGTATGAAGGTTCTTTGCCACCGACCATCTCTATAAGAGTTGGAGCAAAATC AATG TTGTTAATCATCAGGTCCGACTTGGCTCCCTTGTAAGGACATCTCGGGTCGCGGACTATG AAAG GCATTCTTTGAGATTCTTCATACATCCATCTCTTATCCTGCAGATCGTGTTCGCCAAGCA TCAT ACCCTGGTCGCCTGTATATACGATAATGGTATTTTCCCAGAGTCCTTCCTTCTTGAGATA GTCG AAAAGACGTTTCAGGTTGTCATCCACACCCTTTACGCAACGCAGATACGATTTCAGGTAA TGCT GGTAGGCAAGGTATGTATTCTCCATTTCATCACCTGTATTGCACTTATATTCCATTACAT AATT GCGGATTTCATGACGGCTTGAGACAGAAGTTCCGATGAAGTGACGAAGTGAATCGTTCTT GCCT CTTGTGCCTTCGGAGCCCCATTTGTCTGTATCGAACAATGACAATGGAACAGGCACTTCC ACAT CGTCAAGATAATATTCATAGCGCGGTGCGTACTCGAACATATCGTGCGGTGCCTTGTAAT GATG CATCATGAAGAAAGGTTTGGACTTGTCGCGTCTGTTCTTCAACCAGTCAATAGCAAGGTT GGTC ACGATATCCGAGGAGTAACCCATTTTCTTTATCTGGTTATTAGGCCATTTCTTGTCAGTT ACGT CACTTGTAAGGAAAATAGGGTCGAAGTATTCGCCCTGTCCGCCATGACCGTTGAATACAG AATA ATAGTCGAAGTGCGACGGTTCGCATCCCAAATGCCATTTACCGATCATGGCAGTCTGATA TCCC ATATTATGGAACTCATCAACCAGATATTCCTGGTCCGGCTGAAGCACTTCATCCAAAGTG AGCA CCTTGTTACGATGGGAATACTGTCCGGTCATGATACATGCACGGCTTGGGGTACTGATGG AGTT TGTACAGAAACAGTTCTCGAAGAGCATACCGTCCCTTGCCAGTTCATCAATTGTAGGAGT AGGG TTCAGTACTGCAAGACGACTTCCGTATGCGCCGATAGCCTGCGAAGTATGGTCGTCCGAC ATGA TGTAGATGACATTCATCTGTTTCTGCTGTGCTGCGACACCAACACATACAGACAGGAATG GCAT AACAGCCATTCCCTTCATTATATTATTTTTTAAATTCGTTTTCATAAGTCAGATTATCAT TGAA ATAGAACTTGCAAGACATATCATCGAATGATTTTACGTCCTTATTCTGCATTTTAACCCA TTGT TCTGATTTAGCCTTGACAGCGACCTGAGTTGAAACCTCATTACCGTCGACTACACTTTTA AGAG TGACATTTGCATCCTCTGCATTATGGTTTGCCACACGTACAGTGATAAGGCATCCGTTAT CAAC CTTATCGTATAGCGGTTTGGAAACCACCGCCCCTTTAAGCTTAATCTTGAACACATGTGC ATAT TCAGTAGGTTTGTTCTTAGGGAAGTTTACTACAAGACCCTCGTCAGTCATCTTATAGTCA ATCT TCTCTGAGCTTCCAAGCATTTCAACCGACTCAATTTCCACGTTCTGGCAATACTTAGGAG CAAA TGACTTGATAGTAACACTACCATCTGTCCAAGCCAGAGACACGGCATAGAGGTTATTGTC GCGT GTAGTAAAGCGAATGTCGTCCGCTGTATATTCAGTTTTTGTATTGTCTGTCATATAACCT GCGG TGCCTGCGTTATGTCCTTCGAAAGCAATCACCCATGGTCGTGAGCCATAAATAGCCTCAC CGTT AGTCTTCAACCATTTACCTATCTCGGCAAGTACGTTCTTCTGTTCGTCTGTAATAGTACC GTCG GCCTTAGGACCTATATTCAGCAATAAGTTACCGTTCTTGCTGACAATATCAACAAAGTCG TCGA TGATATGGTCAGGACTCTTGTTTTCCTCGCCCACACAATAGCTCCACGATTTCTTGCCTA CAGA AGTATCAGTCTGCCATGGATATTCACGGATTCTGTCGCTCTTACCTCTTTCTATATCGAA CACC TGGATATTGTCGCCATATCCGAATTTAGTGTTAACCACAACTTCTTTATTCCAATCAAGA GCCG AATTGTAATAATAAGCCATGAATTTATAGAAAGTAGGCTGGAACGGATATTTTCCCACAG TCCA GTCGAACCATATCAATTCAGGCTGATATTTGTCGATAAGCTCGTATGTATGCATAAGGAA CTGA CGGCGTGAACGTTCGTTCGAGCCTTCATACTTACCACAATAAGGTGTCATACCCTGACCT TCGG GCTCATGCAGTCTTTCGCCATACAGAGTGATTGTAGTGTCCTGAACATCAGAAGGAGTTT CCAT TCCATATTCATAGAACCATGCATTCTCGCATCTGTGAGAAGAAAGTCCGAAACGCAGACC GGCT TTCTTGGTAGCTTCCTTCAATTCGCCGATTATATCCCTTTTCGGTCCCATATCCACAGCA TTCC ACTTATTGAAAGTACTGCTGTACATGGCAAATCCGTCGTGATGCTCGGCCACCGGAACAA TGTA TTGTGCTCCAGATGATTTTACCACTGCCAGCCACTCGTCGGCATTGAAATTTTCGGCTTT GAAC ATAGGGATGAAATCCTTATATCCGAATTTGGTCAAAGGACCGTAAGTCTGTACGTGATAC TTAT TAATAGGATGACCTTCCTTGTACATCCAGCGGGAATACCATTCACTGCCGTATGCAGGAA CGGA ATAAACTCCCCAGTGGATAAAGATACCGAACTTGGCATCCTTAAACCATTCAGGAATAGT GTAA TTTTGAGCAATCGATGCCGAATCGGCCTTGAACACATCAGTACCTTTTAAAGATACAGTA GAAT CTACATTAGGAGCGTATGTAGAATTGCACGACGCCAACAGGCTTAATGCCGCAACTCCTA AAAC CGTTTTCATGGATTTCTTATTCATAATAATCTTATTACATTAAATAATGACATTAATTTT TTCT GTAAGCAAAGATACACTTGAGTTCCATTTACAATAAATAATTTAATTACTATAGTAAGGG GTAA AATATTTACCACCTATTATTGAACAAATTTACCCCCTCTCATATATGATAATAAACTGCC AATA TCGAATTACAAGTAAATATATATTTCAACAAAAAAGGTTTAGCCTATTATTACACAACAA TTTC ACCCTAAGAATAAAATATATATAGAGTAAATTTGCCAATATAACAAACTGTAAAAACAAA TTTA TGAAAAACTATTTGATTTACTTACTCGCAGCAGTATCGTGTACAACTGTAGCAGACCTAA ATGC TCAAGTCAGTACAAAAACAGGTAATGAAACCACAGAACTTACAATTCCGAAAAAGTTCTA CAAG GACAGCATTGATTTCAGCAATGCTCCGAAAAGACTTAACAACAAGTACCCTCTTTCCGAC CAGA AGAACGAAGGCGGATGGGTTCTAAACAAAAAGGCCTCTGACGAGTTCAAAGGAAAGAAGC TGAA TGAGGAAAGATGGTTCCCGAACAACCCTAAATGGAAAGGAAGACAACCTACTTTCTTTGC AAAG GAGAATACTACATTTGAAGACGGCTGTTGCGTGATGAGAACTTACAAGCCAGCAGGATCA CTGC CCGAAGGATATACTCACACTGCCGGTTTCCTGGTAAGCAAAGAACTTTTCCTTTACGGAT ATTT CGAAGCAAGACTGAGACCAAACGACTCGCCATGGGTTTTCGGTTTCTGGATGTCGAACAA TGAA AGAAACTGGTGGACTGAAATAGACATTTGCGAGAACTGCCCCGGCAATCCTGCCAACAGA CATG ACCTGAACTCGAACGTGCATGTATTTAAAGCTCCAGCAGATAAGGGTGATATAAAGAAAC ATAT CAACTTCCCTGCCAAATACTATATACCATTCGAATTGCAGAAAGACTTTCACGTATGGGG ACTT GACTGGAGCAAGGAATATATCCGACTATATATAGACGGAGTACTGTACAGAGAAATAGAG AACA AGTACTGGCACCAGCCATTACGCATCAATCTTAACAACGAATCGAACAAATGGTTCGGAG CCTT GCCGGACGACAACAATATGGATTCTGAATATCTGATAGATTATGTAAGGGTGTGGTACAA GAAA TAAGAAATAACATAATCTGAAATTATAAAAGGCAGTCTTCATTATCAGTATGCTGATGAT AAAG TCTGCCTTTTTAACAAGAAGATAAAGATTTTAATCTGCCCTATCACTCATTTACTTCATC CGGA TACTCTGTAAGCGAGTTTCCCGAATTGCTTATTTCAATAGAGCCGATAGGAAGATAATTG AACT TCTTGCTCCATGCAGAGATACCATAATCTCTTCTAAGAATAGGCATCATGACCTCCTCGG CACG TCCTGAGCGGACGAGGTCAAACCATCTGTCACCCTCGCATGCCAGTTCACAACGACGCTC ATAC CATAGAACATCAATTACGCTTTTAAATCTGTCAGGATACATCTGCATTAGCTTGTCAACA TCAA TATAACTTCCGTCGTCTGCATGAACATGCTTCTTTCTGAGTTCATTTATGTAATACTTCG CTTT TGCTTCATCAGGATTAGTACCTCTGAGATATGCTTCGGCAAGCATCAGATACACTTCACC ATAT CTGATGACCCTTACGTTTCCAGGCTTGTTTAGATTGGGGTTTCCTATCATATCGTAATTT TTGA AAGGAGGATATTTCTTCTGGGCATATCCCTGGAAATCAGGCCCGTAAGAGCCTGTCTCCC AAAC AACTTTTTTTGATTCATCCTGAATATTGGCATTAGGTTTGGTTACAAGTTCATCGTAAGT AAAT ATCGCCGCATCACGACGCACATGGTCATCCGGAAGGAAATAATCATACAATTCCTTAGTA GGCA GACAAAAGCCATATCCATTATCATAATCAGGACTATTTTTCAACTGTCTCGGTCCGCAGA AAGT CACCCACATAGCACCTTCGCCTGCATCAATATTACCCCAGTTTGTATTACCAGATTTGGT AGAG GTCTGTATTTCAAATATAGATTCCTCGTTATTCTCCTGATGAGCCGCAAACAATTTAGAA TAAT CATCCGTCAGAGTATAATTACCACTTGAAATTACATCCTCCAATAAAGGTTTCGCTTTGT CAAA AATCTTAGCATCATCGTTGCTCCAGTCAGCCCAATAAAGATAGACCTTGGCCAACAGGGC TTGA GCCGCAGTCTTGGTAATACGTCCTTTCATTGTGTCCGGGAAATTATCCTTTAGAGAAGGG ATAG CTTCAAGAAGATCTTTCTCTATTGCTTTATTTACATTTTCGCGAGTATCTCTCGTAAACT TGAA TCCTTCAGGATAAAGAGTCTCAAGACTGATAAAGCATGGACCATAATATCTCAACAATTC AAAA TGATACCAAGCACGTAAGAACTTAGCTTCAGCTTTATAAACTTTAGCTTCCGGACTGTCA TACT CTGAATTTATTACAAGATTACATCTATATATACCACGGTAACGAGTTTTCCACAAATTAT CGGA AATAGAATTGACACTCGTATTTGAATAATCCTCTATAGCCTGCATGTAAGGCTGATCCTG ATCA GAGCCACCACCAGTACGAGCATTATCCGAACGGATTTCACCCATAGGTACAATGGAAGCA AGTG CATTACCCGAAGCACCACCTATGTGAGCTAACGGATCATAACAAGCAGTAAGCGCTTTGA ACAT CTGTTCATCGGTCCTATAAAAAGAACTTTCTGTTTCGGACATTATAGGAGCTGTATCCAG GAAA CTGTCGCTGCAAGATGATGATGCAATAGCAGCAAACATGAGGACAAGAATATTATTATGT ATTT TCGACTTCATAATTTTCAATTTTAGAAATTAAGACTTAAACCAAATCTGAATGTACGGGC CTGA GGGTAAGTACCATAGTCAATACCTGTGCTAAGAATATTGCCACCTGCCATATTTCCTACT TCAG GATCCATAAACGGATAGCTGGTGAAAGTGGCAAGATTATCAATTGCTGCATAAATTCTTG CTTT ATTCAGCATCAACTTGTTTATTAATTTAGTTGGGAATGAATAGCCTACCTCAAGTGAAGA AATC TTTAAATGCGAACCATCATAAAGATAAAAATCGGATGGTTTGCCAAAGTTTCCATTAGGA TCTT TGGATGAAAGACGAGGCACTCCATTATCATCACCTTCTTTCCGCCATCTGTCAAGATAGA ATGA TGGAAGGTTGCTGCGTCCGTATGCTTCCTGTCGGTAAATATCAGAGAAGACTTTATATCC AGCT TTTCCTGTTAAGAAGATTGTCATATCAATACCTCTCCAGTCGGCACCTAAATTCAAACCG AATG TCCATTTTGGCCAAGGATTGCCACAATCGGTTCTATCTTCATCTGTAATCTGCCCATCGT TATT TGTATCTTGCCATATAAAGTCACCCGGAACGGCATCAGGTTGTATCACTTTACCGTCTTT TGAT TTATAGTTCTGTATCTGCTCTTCATTTTGGAATATTCCTAAGTTCTTATAAAGGCGGAAA TAAC CCATAGCATGACCTTCCTCCATACGCGTTACATTAACAGATGTTCTCCAGCTACCACCAT CAGT ATATCCATTTACATTTCCTATCTTTACAACCTCATTTTTAAGATATGAGGCATTTGCGGA AATA GAGAAGTTGATTTCGTTCCAATTTTTATTAAATGTCATCTGCATTTCCACACCCTGGTTT GTTA TATTACCAAGGTTTCTAAAAGCTGCATTATTACCTCTAATGGCTTCAACTGTTGGCTGGA ACAA CAAATCCTTAGTACTTTTTTTAAACCAGTCGAAACTTGCTCTAATCATACCATTATAGAA TGTC ATATCGGCACCAACATTAAATTGTTCAGAAGTTTCCCATTTCACGTCTGGATTAACAAGG TTAT TAGGAGCAGATCCCACAGTGATGGCATTACCAAACGTGTAATTATAATTATTGCCAATAA TAGA AGTATAGGAGAATGGAGAAATTCGCTCATTTCCGTTCTGTCCCCAAGAGAATCTAAGTTT GAAG ACATCAAAGTTCTTAATTTTCCAGAATTTCTCATTTGAAACATTCCAACCTAATGAAACG CCCG GGAAAGTAGCATATCTGTTATTGGGACCGAAATTTGAAGACCCATCGCGTCTGACCACAA CTTC CGCCATATATTTTTCAGCATAATTATAGCTTAGACGAGCAAAATATGAGAACATACTATG TCTA GGATTAGCACCGCCACTATTAGCTGATGTCATAACATCACCAGCATTAAGATACCAGTAA TTCT CATTGGTCATTGCTTCATTTGGATATTTATTTCGTGTTCCGGCCATAAACTCATAAACAT CTCT TGATGCAGAAGTACCTAACAGGACAGATGTAGAATGTTCACCAAAAGATTTTTTATATCG CAAT GTATTCTCCCACTGCCAACTACTATTAGCATTTGTACTTTGTTCTACCCTAGAATTATCT TCTT TACATTCTGCAGAATGAAAAAACTTTGGTGCAAACATTCTTCCACGGAAATTCCGATGAT TAAT ACCAAAATCTGTGCGGAAAACAAGGTCTTTAATAAAAGTGATCTCAGCATAAACATTACC AAAA AATTGCTGGGTAATATTTTTATTCTTAGGTGCCTCATCCATAAATGCAATAGGGTTCCAC ATAC GGCTATAAGGTACAGGAGAGACTCCATATCCGAAAGTATCGTTGCTATTCTCATCATAAA CCGG AGTAGTAGGATCAATATTATAGGCGTATGATATCGGATTATAACCATTGATACCGGTTGC CACT CCACTATTCTCTATATATGCATAGTTGACGTTTGCACCTACACTTAAGAAATCATTTATA GAAT AGGAACTGTTCAGCCTTGTGCTGAATCGTTTGTAAAATGACGCATCTTCACCGATAATAC CATT CTGGTCTAGATAATTCAATGAAAGCAAGCTTGAACCCTTATCACTGCCAAAGTTAGCAGT AATG TTATGCTCAGTAACAGGAGCTGTATTCAATATTTCATTAAACCAGTCTGTATTATAACCT GTTG GAGCAGTAGGTACACCACCGGCAAGCGGCATATCATCATTGTCGGCAAACTCTTTCATCA GCAT AATGTACTGTTCATCATTCAGCATGGTTGGTTTCTTTGCTACTGTAGAGAAACCATAGTA ACCA TCATAAGCAAGCGATGTCTTTCCTTTCTTTCCTTTCTTTGTGGTTATAAGGACTACACCA TTAG CGGCTCTGGCACCATAAATAGCAGCTGAAGTTGCATCCTTCAAGACTTCCATGCTTTCAA TGTC GTTGGGATTTACACTGTTCATGTCGTCCATAGGCAGTCCGTCAATTACAAAAAGAGGATT AGAG TTTCCATTTGTACCAACACCACGAATTACCAGCTTCGGTGCTGTTCCTGGCTGACCGGAA TTTG TCACAACGTTCACACCACTAACCCTACCGCTCAATGCATTCACGGCATTTGCTGGTTTAG ATTG CAATAAATCATCGGAATCGATGCTACTGATAGCACCTGTTACAACACTTTTTTTCTTAAC CTCA TATCCTATTGCTACAACTTCCTCGAGTGCAATGGCAGATGTTTTTAATTGAACGTCTATC TTAG ACTGACCTTTATACACTATATTCTGTGTATCATATCCTACGAAGCTATAAATCAATGTCG ATTC CATTGGTACATTTTCCAAGATATAATTTCCGTCCAAATCAGAAATAATACCGTTTGTGGT ACCT TTAACTAAAATACTTGCACCTATCACAGGTAAACCATCGGAGTCTGTTATACAACCGGTA ACTT TCCCGTTCTGTGCATTTAATGGTAAACTGAACGTTATAAGAATCAGCATACACATTAATG ATAG TGTTCTGTTCATAATCTAGAGTTTTTTGTAATTAGTGTTTTTCTTAAAATAAAAAGTTTT GTTC TATCAGTTGCGCGCTACTTACTGACACTTGCAAATATATATACTATGTAATATAACCAAA GGGG GAAAATTTCATTTAAATAGGGGGGGGAAATAGATTAACTAAATATTTTAAGGAAAAATGG CTGT TAGAATCCATTCCCAGACTCCAACAGCCATTTTATCACTAACAATCGCCTGTTAATCAAT ATAT TTTTCTGCCCATTTCCTTAAGATTTGCATCCCTGCCCAGTGGAACAAAAGTAAATCCGTA TGAA TAGCTTCCCTTCAGAAGACGCTTGTCTATTGAAGGACGGGCTTTCAGACTCCAGCTATCT GTTC CGCCCACTCCAGCCTGAACCAGGTCGATATTAAGAGTATTAGAATACAAGTCCTTTTCAA GTTC ATTTATATGTTTAGCCTTATCAATCGCATTCTGCGACATCTCCCACACTGAAACAGATAG GGGT TCATCGCCGACAATCATCACACCTGCCTTATCCGACTGCAAGGCAAACCATCTCACGTCA CAAC GGTTTCCGTTTTCCTGCGGCATTACATAGTCAAATCCCAGAGCGGACACCTTGCAGTTAT ATAT AGACACCATTGCAGAGGCTTTTCTGTCGGAATAGTTTTCCCATGGGCCACGTCCATAATA TGTC ACATCCGACAAACGATTGGTACATTCGCATTGCAATCCTACGCGCAACATTTCTGATATT TCAG GAGACTTCATCATTGAATAATGAACGCCTATTGTTCCGTCTGCTTTTACTTTATAATTCA AGGT AAGTCTCAGTCTTTCATCTATAGCCTTTAGCACCTTAACCTCAAGATTGCCTTCCGATTT GCGT ACATCTATAGAAACTGTCTTTAGCTTTAATGGAGCATCTTTCCAGAATGCAAACAGTCTA TCGA CCTTCCATCCTCGCCAGTCATTGTCTGTTGACGCTCTCCAGAAGTTTGGTTTCAGAGCAG ATGT GATGATACTTTCATTATCTATCTTATACTGACTGATATAACCATCACTGATATTCAGATA AAAG TTCTTTCCCTTCACGCTGATGTCTTTCTTGTTATCTGAATCGATTTCCATATCCAATGTA GTAT CAACGCATTCTACTATCTTTGGTAAAGAAAGATACTTAAACTGTTCCCAGGCAACCTCGT ATCC AGCTTTGGCATACAGATTGTCATTCTTGAGCCTGGCACTCAGGAATAACCAATATTCCGC ACCG TCATCGGCCTTGAAATTCTGAATAGGAAGTTTTAGTTTACAGCTCTCACCAGCTGGTGTT GTCG GCACAATAATCTCACCTTCCTGCAATACACTGTCTTCGTCCTTCAATTGCCAAAAATAAC GATA CTCATCTGTTGAAAGGAAGAAGTTTCTGTTTTTTACAGTTATCTCTCCACTATAGACATT ATCA GTTGTAAATGATACAGGAGCAAACACGTACTTGCATTCCTCAGTAGCAGGTTTAATGGAG CGGT CGGCACTGATAACACCATTTATACAGAAGTTTTGGTCGTTGTGCTCCCCTTTCTCATAGT CACC ACCATAATTCCATGATTTCTTATTATATTTCCGTTCATTATCCAGCAATCCCTGGTCTAT CCAG TCCCAAATATATCCGCCGGCAAGCGCATCATGAGAACGTATTGCATCCCAGTATTCTTTC AGCC CGCCGGTAGAGTTTCCCATAGAATGTGCATATTCACACATTATTATCGGACGGTTCATGA CCGG ATTCTTAGTCATTGCTATAAGCTCATCGACCATAGGATACATACGGCTAATGACATCGAC GTAT AAAGGATCATCGGGATTGGCATACACACAAAGCTCTTTCTTTGCCGGTTTGACATCTTCG TTCA CATTAAAATCTATCTCACTAGTAACGATTGACGCTTCCTTACGTCCGATAGGTTTGTATA AAGG ATTTTCCGGCTGTCCTTGCGCCCCCTCGTAATGAACAGGACGGGTTGGGTCATAATCTTT CAGC CATCCTGACAGAGCTGCATGATTAGGGCCGCATCCAGACTCGTTGCCCAACGACCACATA AACA CAGAAGGATGGTTCCTGTCTCTCACAGCCATTCTTACCACTCTCTCCATGAACGAGTTAG CCCA CTCAGGCCTATTGGACAGATACCCCCTTTGATGATGAGTTTCAAGATTAGCCTCATCCAT TACG TATATACCATACTTATCGCACAGTTCATAGAAATAAGGGTCGTTAGGATAGTGCGATGTA CGGA CTGTATTGAAGTTATAACGCTTCATAAGCAGAACGTCTTCGAGCATCTCATCACGTGTAA CGGT CTTACCTCCGGTCTCGCTATGGTCATGGCGGTTTACACCAATGAGTTTAATAGGAGTGTC ATTC ACCAGAATCTGATTACCTGTTATTTTAATATCCCTGAACCCTACCTTATTACTTCTCGCA TCCA CCACGTTGCCCTTTTTGTCTGTGAGCTTTATAACCAAAGTGTATAGATAAGGGTGTTCCG AATT CCATAGTTTTGGCTTAGAAACAATTCCCTCCATCATTCCGTAATAAACATTATCACGCTG AGGA TAAGGTTCGTTCACCACATAATCGGCAGTAACGGTAATGTCTTTTCCAAACACCGGTTTC CCAT CGGCATCATATAATTGGGCTGACAGATTCCATCCCTTCAAATCATCCATATTCTGATTTG TTAT TTCCGGACGGATCTGTAACCGTGCTATATTCTTCCGGAAATCGATGCGTGTCCTTACTCC ATAA TCATATATTGCCACCTGCGGAATGGACATGATATATACTTCACGATGGATACCAGCCATT CGCC AGTGGTCGGCATCTTCCATATAACTTCCGTCGGTCCACTTATACACTTGCACCGCCAGTT TATT CTCCCCCTTCTTAACGTATTCGGTAATATCAAATTCAGTAGGCAGACAACTGTCTTCGGA ATAT CCCACCTTCTGTCCGTTTATCCATACATTAAATCCCGAATAGACGCCTCCGAAATGGAGT ATAA TCCTGTCGCTCTTCCACTTGTCAGGAACAACAAACTCCTTGATATAACACCCCGTCTGAT TATT CCTGTCAATATATGGCGGACGAGCAGGGAAAGGATAAATAGTATTTGTATATATAGGATA GCCA TATCCCTGCATCTCCCAACATGAAGGAACAGGAATAGTTTTCCATGATGATGAATTGTAC TCCA CTTTATAAAAACCGGCGGGAGCCAATGCCATATCCTCGGAAAAGTTAAACTTCCATTGGC CGTT CAACGACATATACTCCGATTTCTCTCTGTCTCCATCCAAAGCCCAATCCACTCTCCGGAA AGAA TAAGTAGTACTGCGGGAAGGCAAACGGTTAATTCCGTTTATGGTCTGATCCTGCCATACA TTCT GATTGTTTCTCCACTGATTGGCACCGTTGTCCGATGCAGACAGAAATTGCATCATGAAAA ATAA CACAGAAAATGAAAAAATAGATTTTAAGTTCAAGTTCATAAATTCGCATTTTAAGTTTCT ATGC AAATATATAAGTATAACGAACAATGAATAGGGGGTATTTCTATCTATATAGAGTGGTATT TTTA CATATGAGCTAAAACTTAAAAAAAACTGTCAGTATTACTATGCTATGTAGCACTCTATAT GAAA ATATTATATATTCCCAAGTCAAAAGCCTTTTCAAACAATTTTTATATATTCTCATCCTAT CCCT TCCATCAAAGATAAATTCCAATCCTGATTTGCCAGCCGCATTTATTCCTTTTTTCAGGAG AATT TTCTTTATGGCTATCGCCATGAAAATTCACCTGAAAAAGAATGCGGCGGCAAACGGATTA GAAT TAAAGAAAAGATTACAGGGATTAACTGCGACCGACGTGACGCATAGCCGTAATTCAAAGG CGGC TATCCTTATATTCCATATATGACCTCACAAATACTGTGAAAATCCACTTTCCCCAATAAC AAAA CATAGCCTGCCATATCAACACCCAAAATAAGACAGGGATTTCAACTCCCTCCGATCTGCA TAGT CTGGTGGCTTCGCTATGCTTTTACTCCTACATCCATTTTTTTTCTTTCTTTTTTCCTCTG TTCC CGTTCTTTCCTATCCTTCGTGTGACATTTGATGACACCTGATGACATCTAATGTCATCTA TTTG TAAATCAATTGTTTACTCAATTTATCATCTTACATTTGGACTGTGAAACAAATCAAGTAG TCAC TCAAAACAAAAGATTATGGCACAAGAAAACAGTCCTGACAAGGAAAAAAGGCAAGGCCGG ACAA AGAAACCCGAAAAGCCTTATGTGGAACAAATTGACGAGCTTCTGCTGGTACATAACAAGA ATGA CCCAAAGGAAGGTTTGGGAGTAATCAGCAAGATGGACGAGAAAGGCAATTATCAGACGGT TACA CCGGAAGAGAAGAATGAGAACTCATTCCTGAAATTCGACAAGAATTCGAGTATTCTCGAA AACT TCATCAAGAATTTCTGGAGCCAGCTGAAGGAGCCTACGCATTTCAGGCTTATCCGTATGA CCTT CAATGATTACAAACAGAACAAACAGGCTCTCAAGGACCTGGCCGAAGGCAAGAAGACAGA CGCG GTAAAGGAGTTTCTGAAACGCTATGAAATCAGACCGAAAGTAAACAATCAGAAAAACAGT CAAA CAAAAGAGGAGGAAACAACAATGGCAAAGAAGCAGGAACAGACAACGCAGGCTCAGCCTG AACA GGTATCACAGGTGGAAGCTGCCGCACAGGGGCGCGAACAGCAGGAACCGCAACGCCAGCA GACA CCCACGTACCGCTACAACGAGAACATGATTAATTGGGAGGAACTGGGTAAGTTCGGTATA TCCA AAGAAATGCTGGAGCAGTCCGGACAGCTTGACAGCATGTTGAAAGGATACAAGACCAACA GAAC CATGCCGCTGACACTCAACATTCCTGGGGTACTGACCGCAAAACTTGATGCACGCCTTTC GTTC ATATCCAACGGCGGGCAGGTCATGCTGGGCATCCACGGTATCAGAAAGGAACCTGAACTG GACC GTCCTTATTTCGGACATATCTTCACGGAAGAGGACAAGAAAAACCTGCGTGAAAGTGGAA ACAT GGGACGCGTGGCTGACCTTAACCTGCGTGGCAACACGACAGAGCCGTGTCTGATTTCCAT CGAC AAGAATACCAACGAACTGGTAGCCGTACGGCAGGAGCATGTCTATATCCCGAATGAAATC AAAG GGATAACCTTGACTCCGGACGAAATCCAGAAACTGAAAAACGGAGAACAGATATTCGTAG AGGG AATGAAGTCCAATCAAGGTAAAGAGTTTAATGCCAATCTGCAATATAGTGCGGAAAGAAG AGGC ATCGAATTTATCTTCCCGAAAGACCAGGCTTTCAACCAGCAGACGCTTGGCGGTGTACCG CTTT CCCCCATGCAGCTCAAAGCGTTGAACGAAGGACACACCATCCTTGTAGAGGATATGAAAC GAAA GAACGGCGAACTGTTTTCTTCCTTTGTTACCATGGACAAGGTTACAGGCGGGCTCCAATA TACG CGCCACAATCCGGAAACGGGAGAAATCTACATACCAAAGGAAATCTGTTCGGTACAGCTC ACAC CGGAGGACAAGGAAGCGTTACGCAAAGGGCAGCCCATCTATCTTGAGAACATGATCAACC GTAA AGGTGAGGAATTCTCGTCATTCGTCAAGCTGGACCTGGCAAGCGGAAGACCACAGTATTC CAGA ACTCCGGACGGTTTCAACGAACGACAGGCACCAGCCATCCCGGCTGAGGTTTACGGACAC CTGC TTTCGGCACAGGAAAGAGCTAATCTTCAGGACGGAAAGGCTATCCTCGTAACGGGTATGA AAGG TCCCAACGGCAAACCGTTCGATTCCTATCTGAAAGTAAACGCAAACACCGGACAGCTGCA ATAT TTCCAGGAAAATCCGGATGTGCGCCGCAATACTTCACAGCGTGCTTCACAGACTGACAAT ACCC AGCAGCAGGAACAGAAGAAGGGAGCAAAACAGGCTGTCTGACCTGAACGGGATTCAAATC ATTC AAATCATCAATTACTAAAAAAGGAAAGAACATGAACAAGACCAATCATCATATCTACAAG ACTG AACAAATCGACTGGGAGAAACTGGAATCGGTAGGTATCAGCAGATCGCAAATTGAAAAGG ACGG AAACATGGACCTGCTCCTTCAGGGAGAGGAAACCAATGTCATGTCCATTAAAATCAAGAC TCCT GTATTTTCACTGACCATGGACGCCACACTCAGTCTGATTGAAGACGAGAATGGAAATCCG GTCA TCAGCGTAAACGGTATCAACCCTTCAGGTGAATAAATAAGAAACCATAATGTATCATCTC TCTT TCCATACGGACTTACCGTATGGAAAGAGATAAAAACAGAATTTATCATGATTGCCATATT AACA GACAAACCAAGTGTAGGAAAAGAAATCGGAAGAATCATCGGTGCAACCAAAGTAAGAAAC GGAT ATGTGGAAGGAAACGGCTACATGGTTACATGGACTTTCGGGAACATGCTGTCACTGGCCA TGCC GAAGGACTACGGAACCCAGAAGCTGGAACGGAATGACTTTCCTTTCATCCCGTCCGAATT CGAA CTGATGGTACGGCATACACGCACCGAGAACGGATGGATACCGGACATTGATGCCGTGCTC CAGC TTAAAGTAATCGAGAGAGTGTTTCAGGCATGCGATACCATCATTGCGGCTACCGATGCCA GCCG TGACGGGGAAATGACATTCCGCTATGTCTATCAATACCTGAACTGTACACTGCCTTGCTT CCGT CTGTGGATTTCCTCTCTTACCGACGAGTCTGTGCGTAAAGGCATGGAAAACCTGAAGCCG GACA GTTGCTACGACAGCCTGTTCCTTGCTGCCGACAGCCGCAACAAGGCGGACTGGATTCTCG GAAT CAACGCCAGCTATGCCATGTGCAAGGCGACGGGCCTTGGCAACAATTCTCTCGGACGGGT ACAG ACACCGGTACTGGCTACCATCAGCAGACGCTACCGTGAAAGGGAGAACCATATTTCATCG GACA GCTGGCCCATCTACATCAGCCTGCAAAAGGACGGCATCCTTTTCAAGATGCGCCGCACAC AGGA TCTTCCCGACAAAGAATCCGCTACAATGTTTTTCCAGGACTGCAAGCTGGCACATCAGGC ACAG ATTACAGGTATCAGCCACAGCGTTAAGGAAATACTTCCACCGGACCTGCTTGACCTGACA CAAC TTCAGAAGGAAGCGAACATCCGCTATGGTTTTACCGCATCAGAGGTGTATGACATCGCCC AGTC TCTTTATGAAAAGAAACTGATTTCCTATCCGCGGACTTCCAGCCGTTATCTGACGGAGGA TGTG TTTGACTCGCTTCCACCAATCATGGCGCGTCTGCTTTCATGGGAGCTGTTCCCTGCAGCT AAAG GAACTGGAGGTATTGACATATCCAATTTGTCCCGCCACGTAATAAGCGCAGAAAAAGCCA ATGT ACATCATGCCATCATCATTACAGGTATCCGTCCCGGAAATCTGTCCGAAAAGGAAATACA GGTT TACAGACTTGTAGCCGGAAGGATGCTTGAAACATTCATGGCTCCATGCCGCATAGAAACG ACAA ATGTTGAAGCGGTTTGTGCGGCACAGCATTTCAAGGCCGAACAAACAAGAATCATTGAAG CCGG CTGGCATGATGTGTTTATGCGTTCCGACATGGTTCCAAAATCAGGATATTCTGTCAATGA ACTC CCCGAAGTGGAGAAAAGTGATACTCTGAATGTATGCGGATGCAACATGGTACACAAGAAA CAGC TGCCGGTAAATCCGTTCACGGATGCAGAACTGGTGGAATACATGGAACAGAACGGACTGG GTAC AGTATCCTCACGTACCAATATCATCCGTACACTGGTTAACCGTAAGTATATCCGTTATTC AGGG AAATATATCGTTCCGACCCCGAAAGGCATGTTCACCTACGAAACCATCCGTGGAAAGAAA ATTG CGGATACTTCACTCACCGCAGACTGGGAAAAACAGCTGGCCGGACTTGAAAGCGGAATGA TAAC CGGACAGGACTTCCTGAACAGGATCAGGACTCTCGCCAAGGAAATGACTGATGACATTTT CAAC ACCTATTCCACAAAAGAAGAATAACATCTATACCTAATCAACCAAGAGAATGCAGGCCGG AAGG TCTGCATTTTTTTGTATCCGTACAGAAAAGAATCTGTTTTTCCGCTTTTAAGCGGCAAAG GTCT TGGATTGCCTGCCTTTTGCCGCAAGGCTGCCCTCATGGGCTTGGCTGGACAGGAAAAAAT CATC CTCGCTGCGCTCCGGTATTTTTTCCTGCCAGGCCTTGCGCAAAAAGGCAATCCAAGAGGC CGGA GGCCTATAAAATCGGGAAAACACATCCCGATGGGATTATTCATTCATAAAATTAAGGATT ATGA AACTACAGATTATCAGAAAGATCGGCAGACATGCAACAGCGATATTCCTGATTACCGGAA TATG TCTGCTGACAAGTAAAGGGATTGTCCCTACTGGGATGATTACGCTGCTGTTGCTTGCAGG AGGG TTCATCGGTTTTCTGTTCAGGATACTGGTCATTATTTTCAAGATTCTTATTCTTCTGTTC ATTG TAGGATTATTTGTCGCATAACCCAAAATATAAATATACATATATGGAAACAGTTGCTATA ACCT CACAAGCTCCTGTCATGCCGGCTGTATGGCCACAGAACGAACATATCAGACCGGTTAAAA GACG TCTGCCCAATACAGTTGATGAACCTAAAAATATCGGCTACTATCTGGAATCGCTACGTGA TATT TCCAGCAATCCGGACAGAGAGAATATTCTGAAAGAATTCTTCAAGGAAACTTATGTATAA CCAT AAAATTTTTCAATTATGTTTTTTCAATCAATTTATCAGATGATTACAGCAGGTACGGATC TGAA TATCAATATCCGTAAAGTGGACAACAGCCTGAGCGTAGCAGTCATGCCAAGGCGGAACAG CCTG AAAGAGGATACGCGACAGAACATGGTGCCACTGATCGTGAACGGAACACCGGCAGAACTG GATA TGGGCTTCCTGCAGACCATACTCCAACCGATACAGAAGGTACAGGGACTGCTTGTCAATG CGGA AAATTTCGAGAAACAGGCAGAAAAGGCTACATCACAGGCCAAATCATCCAAGGCTCCAAC AATA CCGGCCGAATCAAAGGAAGCCAGGGAAAAACGGGAAAAGATGGAAAAGCTCCTCAAGAAG GCTG ATGAAGCAACCGCCGCAAAAAGGTACTCCGAAGCAATGACATGGCTGAAACAGGCACGGG TACT GGCTCCTACAGAAAAACAGAAGGATATTGACGAAAAGATGCAGGAAGTACAGAAACAGGC TAGT GCAGGAAGCCTGTTCGGTATGGCAGAGGAACCGGCGCCGGTAATTCCCCAACCACAAGGC TATA TGAACGGTCAGTCACAACCAGGTATGCAAACAAGCATATTCCCGGAGCAACAGACCCATA CTAT GAATCCTGAACCTGTCATGCAGCCTGCTCCACAGCAGGTATCACAACAAATTCCACAAGG AATA CCTCAACCGGCATATGGAACGAACGGGACATATAACCCACCTGCTCCAAACAGCCCGATA GTAA AAGGAGCAGACATACCGCAAGGCGCAACAATGCATCCTTACCCACAGCAGCCATACTACC AGCA AGAGGCGACTCCTTATCCAACACAACAGCCACAGCAACCGACAAACGGACATATACCGAA TGGG GCTGCGCAAGTACAGAATGGAAACGGACGGGAATACCAGACTGCATCGGCTACACATGAG ACAT TCTGCTTCGATCCGGAAGACGAGAATGACAGGGAACTTCTAAGAGAGGACCCGTATGCGG AATA TCCGGATTTTCCGGCTGAGTACCGAATGAAGGACGAGGCACAGGTAGAAATGGTATACTG CTGA TATACACAATAAACGATTTGTAAAACCAATAAACTATAAACAATATGGCACTGGAAATTA AAGG AATGAAAAGAGTATTCAAGATGAAGAAGAACAATCAGGAAATCGTACTGGATGATCCGAA CGTA AACATGTCTCCGGCTGAAGTGATGGACTTCTATTCCATGAATTATCCGGAACTGACAACC GCGA CCGTACACGGACCGGAAATCGAAGACGACCGGGCGGTATATGAATTCAAGACCACTATCG GAGT AAAAGGGTAAGAGCATGAAAAAAGGACAACGTAAAGACAAGAAACCATGTACACAACTTA CGGA ACGGGCTTTGGAAAATTTAGCCAGACTTATCATATCGGAACTCGAAAATACGGACATAAG CCGG GGCATCAGGAACAGAAAGAAAAGAAGACTCCCTCCCGCAGAAAGCCTCATGGTTTTCTGA ACAC GAGAATACCTTCCATCGCTCCCGATCTGTATGTTGAGAATGACAGGGATGTAACGGTAAA TGTC ACCACCAAAGAGAATCTTGATTTCCTGTACCGTTCAGCCATGAAGTATGCGCAGCTCCTG GATG TGGAGCTGCCATACCATCCTACAGGCAGGACTTCCACAAGAGAGAAAATATGCCTGCTAT ATAA TGCACTGGATTCCATAGTATCTCATCATGTAAATCTGGAACTTATTGGTGACAGGCTCCA GTTC TGCATCTACCATTTCCATGAATGGCCGGATTATACGCTTTTCTTTATGCCGATAGACTTT ACGG AAAGGCTGCACGGTGAAATTAAAAAGATTACACTGGAGTTCATCAGAAAGTTCATCAAAT ATCA CAGGATGATGGATATAACCGATACCCCTTATTTTGAGATGTCGGAAGTCTGTATCGATTA TGTG GACTTTGAACAGCTCGATGAGGAAGAGAAAAAGGATTTGTACAGAAAGGAAAAGCTTTTC AGGT CATATGAGAAAGGGAGAATCCACAGGAAGCTGTGCCGGATGCACTCCAGGGCTTTCTGTA GGAA TCTGGAAGAACATATCCGCAACTGTACTCCTTCCAGCGATAAGGAAAGAAGACTTTTGGA ACTG ATTACCGAAGGGCTGTCCCTGATTGCAAAGGACAGCCCTTATATCTTGAATTATGATTAT GATT TTGCAAGCGAAAAGGAACGGGATTTCGAGCCGCCACCGCTCGAATATCAGATTCTGCTTA CATA TTCCATCACGGATACGGTTACCAAAGACATGGAAAGCTGTTTCAGTACTGACTGTCAGGA AACA TATAACCAGACTCCCGTATCATTTACCTTCATCACGCCGGAAACAGAGGAACTTTTCAAG CCGG ACAACTATCCGGAACGGTTTGAGAAATGGTTTGAGAAATTTGTAGAACATGTTACCTATA ATTT ATAAACATCATGAATGAACTGACCAAAAATATGCAAAAAATGATGGTACCGAAGGCTGCA ATCA TAGCCTACAAGTATGAAGACAGAAGAAATCTTGATACCAGGTACTTTATAGAATTACGTC CAAT CAGAAAAAGCGGACAGATGGGGGCAGGTATCCCCGTCACATACGAATTCATGAATACCCT GCTG GAATCCTATACGGAAGAAATGAGCGGGATACCGGCAGGCAGAGTCCCTGAAAACATGCTG GCCT GCAATCCGAGAAAAGGACAGGAAGAATATATCTGGTACAATCCGCCCGGAAAAAGACAGA TGTT CTTTCACAAGGATCTCAATATACAGGACGGCATGTTCAATCTGCCGGGAATTATCTACCA AGTA AAAAACGGAAACATGGACGTGTTCGCTTTCAAGGGGAAACGTCCGGTGGAGACGACTCCG CTGT TCCGTGCCCCGTTCTTCAACGTGACCGGATCAAGTGTCTGCCTTGGCAACAGTTCTCTGG AAAA GCCACAGAACCCGACTTTCCTTTCCCTGCTGGAATACTGGGAAAAACGGTTCTGGCTGAC TGAA TTCTCCCATCTGGGAGGAAATGTCAATCCTACCGTTTCAAATCTTGTCATCGTCACCGAA AATA TAAGAAACAATCCGTTCGACATGAACGAACTCAAGCCCATGAATAAAAAACTTAAAGACA TACT TCCATGAAAAAGATACATTTTACCGACCGCTACCTGCTCAATCCACGTCATCCGGTAACG GTAT TCGTCATCGGAGCTGGAGGTACCGGCTCACAAGTGATAACCAATCTGGCACGCATGAGCA TGGC ACTTCAGGCATTAGGTCATCCGGGACTGCATGTCACCGTATTCGATCCCGATACGGTTAG CCAG GCCAATATAGGACGCCAGCTTTTCAGTGAGACGGAACTGGGACTGAACAAGGCCGTATCA CTTG TCACACGCATCAACCGTTTCTTCGGATACGCATGGACTGCCGAACCGAAATGTTTCCCAA CGAA GAAATTTTCAGGATATGATACAGCCAACATATTTATCACCTGCACTGACAATATACGTTC ACGT CTTGAGATTTGGAAATTTCTAAAGAAAACTCGTAAAGAGAACTTCAATGACTATTTGGTT CCTA TATATTGGATGGATTTTGGGAACAGCCAGACAAAGGGACAGGTCATCATCGGGACGGTAC GTGA GAAAGTTCTCCAACCTTCTTCACAAGAATATATTCCCATGCCTAAAATGAATGTCATCAC CGAG GAAGTGGACTATGCGAAAATCAAGGAAAAAGAATCAGGACCAAGCTGTTCTCTGGCGGAA GCCC TGGAAAAACAGGATTTGTTCATTAACTCCACACTGGCACATATCGGATGTGACATATTAT GGAG AATGTTCAAGGAAGGAAAGACACTGTATCGCGGTGCCTATGTCAATCTGGATACATTGAA AATG ACCGCAATCCCGGTGTAATGACAGAAGTGACCGTATCATCTTTCCATCAGAATACGGTCA CTTA TTCTATTTGCTACTTATTATTTACTACGTTCTTACCACGCTGGAGCAGGAAACTCTGTAT CTCT GAGGCGAGATAGAATGATTTCCCGTTCTTTTCCACCGAGTAATATTTAATCTTGCCCTCT TGCC TGTAACGTGCCAAAGTTCTTTGTGACACACCAAGGAGTTCTGCCAGATCCACATTATCAA GCAG TCTGTCTCCATTCATACATTCTTTCAGACGATTCATCTGGTCCAGTTTCTTTTCAATGCG GGCA AATCCCTCTACCATTGTTCCTATAAGTCTTTCGAGTATCTCATTATCTATATATGACATA ATTC CAATGTTATTAAGTGAATAAATCGATACTCTCTTCGTGCGCACTCTAAGAGTATGTACTT ATAG TAGTGAAAATAGTATGCCTGAATCTAAGACAAAGATCAACAAGCTTATTAGGCGCTGATA ATCA GGCGTATAATTTTTTCTACTTAATATTTAGTGTAAACCAAAAGTGTAAACTATGTAATAC AGAA TTGGGAACGGGTTAACACAGCCACCAACAATGACATCTGATGCTACCTGACGACACCTAA TGAC AACATTTTGTATCATATACATATTCAAAATACATTTGTACAAACTCAACTTTTTTGGATA TGGA AATCATTGGAATTGAAACAGCTACATATGAAAAGACATTAAAGGAAATTGAAAACTTCCT TGAT ACCATTGATAAATTGATTACAGCTTCTTCACAGAAAACAATAGGGGAATGGTTGGATAAC CAAG AAGTTTGCCTGATCCTCAAAATTTCTCCAAGAACATTACAGAATCTTAGAGATACAGACC AAAT CTCTTATTCTCAAATTGGGAAAAAGATTTATTATAAAAAAGAAGATATTCAGAAGTTCAT TGAA AAACACAACAGAAAATTATGAGCAAGGTAATTACCCAAGATAATGAGCAAGTTATTCAGA TATA CAATAGGTTAAAAGATACGCTAACAAGACTCGAAGATATTCTGAAGAATAACAACCCAAC ACTT AATGGGCATAGATATATGAATGATGCAGAATTGGCTAATTACCTTAAAGTATCAAGACGC ACTT TACAAGAATATAGAAATAATGGAATCTTATCTTATTATCAGATTGGAGGTAAAATTCTAT ATCG GGAATCTGATATAGAAGAACTTCTTGAGAAAAACAGACAGGAAGCATTCCGTTAAACATT TCTT GGAATTTTCGTTGATTTTCAAAGCAAAAATCAGTATCTTTGCAATACTGACAAAGAGTTG TATA TCAGTGCAGAACAAAGAAGTTCAATCGAGGTGAAATAGGTGGACTAAATGACAAACAACA AGAT AAGTAATTGATTATTAGCGATAAAAAATATAAGGTTCCGCCCCCAGGCGGATCACTGAAA ACAA AAGAGAAAT [00229] SEQ ID NO: 73 (pWD035 plasmid with porphyran PUL):

aacaaatactttcaggacgatgtaaagtcctgagaaatcaaactgaatggatagata aatatta gtcttttctcatcggattcttttaatatcgctactcttttattatgtagtggttgtatta tctt aaataaaacaaaaacacccgactttacattcttgggtgtaaaacagggtgtttgttttgc aatc tgctgattttcagcgttttttgcggagagacaggctctcgaacttatactttcacagaat atca taaaactgcaaacgactgataatcaagtgtaaattacaatatagagtaaaagtaaatgtt tcta aatgtcttttgctatctcaataattgggtgtatatttgggtgtagaatttcaaacgcacc caat tatgaatatcaagcgcaacatcatttttgcattggagagccggaaaaagaacggtgtgcc aatc gtagagaacgtacccatccgtatgcgtgtcatctttgccagccaacgtatcgagtttaca acgg gctaccggattgacgtagccaaatgggatgcagataagcagcgggtaaagaacggatgta ccaa caagctaaagcaaagtgcagccgaaatcaatacggacttgctgaaatactatgccgaaat ccag aatattttcaaggaatttgaggtgcaggaggtcatgccaacgacccaacagttgaaggaa gctt tcaacatgagaatgaaagataccagtgaagaacagccggaagaagcccctgtcagctttt ggga ggtgttcgatgagtttgtaaaagagtgcggtaaccagaataactggacggcatccaccta tgaa aaatttgcagcagtgaggaaccacctcaaagagttcaaggaggatgcaacgttcaactat ttca acgagtttggattgaacgaatacgtcaacttcctgcgtgacaccaaggatatgagaaaca gcac catcggcaagcaaatgggattcctcaaatggttcctgcgctggagcttcaagaaaggaca tcat cagaacattgcatacgatacgttcaaaccgaaactgaaaaccacctcgaaaaaagtaatc ttcc tgacttgggatgaactgaacaagctgaaagactaccagatacccaaggataagcaatacc tgga acgtgtgcgtgatgttttcctgttctgctgctttacgagtttgcggtattcggatgttcg caat ctgaaaagaagcgatgtgaagtccgaccacatcgaaataaccacagtcaagactgccgac agcc tgacgattgaactgaacaaatacagcaaagccatactggacaaatacaaggacatccatt tcga gaattacatggctctgcccgtcatcagcaaccagaagatgaacgattacctgaaagagct gggc gaactggcagaaatcaacgagcctgtacgggaaacctactacaagggaaatgaacgtatt gatg aagtcacacccaaatacgctttgctcagtacccatgcaggaaaaaggacattcatctgca atgc gctggctctcggaatcccggcacaggtggtcatgaaatggacgggacacagcgactacaa agct atgaaaccctacattgacatagcggatgatattaaggcaaatgccatgaacaagtttaat caac tataaaagtatcaaacagtttcatagatagttaccaatgactgataggtgggctgccctt cctg gttggcttggtttcatcagccatccgcttgccctcatctgttacgccggcggtagccggc cagc ctcgcagagcaggattcccgttgagcaccgccaggtgcgaataagggacagtgaagaagg aaca cccgctcgcgggtgggcctacttcacctatcctgcccggctgacgccgttggatacacca agga aagtctacacgaaccctttggcaaaatcctgtatatcgtgcgaaaaaggatggatatacc gaaa aaatcgctataatgaccccgaagcagggttatgcagcggaaaacggaattgatccggcca cgat gcgtccggcgtagaggatctgaagatcagcgggattaaaagtcggggattggtgaacaaa aagg tgtttctctctttaagagaaatatcgttttgctaaacagttgatattgaggtatcatttt atcg taaaagacatttttgctcaacaattgcttgacggaaatcaacaaattttagcattttgta aaaa agtcgctatataatttggtgaattggagttattttcatatttttgcatcccgaagagttt ctct taaagagagaaacatcttttgcataccttttccgaccgaatttttatgtcgtaaagaggg gctt tgcagggggtggactcagaaagatgagaatagatgactattgtagttgaaacacatagaa agtt gctgatatacagaccgatacgcatatcgggatgaaccatgagtacgttcttttctcaaaa aaca taaatattcgaaaagagatgcaataaattaaggagaggttataatgaacaaagtaaatat aaaa gatagtcaaaattttattacttcaaaatatcacatagaaaaaataatgaattgcataagt ttag atgaaaaagataacatctttgaaataggtgcagggaaaggtcattttactgctggattgg taaa gagatgtaattttgtaacggcgatagaaattgattctaaattatgtgaggtaactcgtaa taag ctcttaaattatcctaactatcaaatagtaaatgatgatatactgaaatttacatttcct agcc acaatccatataaaatatttggcagcataccttacaacataagcacaaatataattcgaa aaat tgtttttgaaagttcagccacaataagttatttaatagtggaatatggttttgctaaaat gtta ttagatacaaacagatcactagcattgctgttaatggcagaggtagatatttctatatta gcaa aaattcctaggtattatttccatccaaaacctaaagtggatagcacattaattgtattaa aaag aaagccagcaaaaatggcatttaaagagagaaaaaaatatgaaacttttgtaatgaaatg ggtt aacaaagagtacgaaaaactgtttacaaaaaatcaatttaataaagctttaaaacatgcg agaa tatatgatataaacaatattagtttcgaacaatttgtatcgctatttaatagttataaaa tatt taacggctaaaaacaataggccacatgcaactgtaaatgtttacgcgggtaccgacaccg cggt ggaggggaattatcacgtgctataaaaataattataatttaaattttttaatataaatat ataa attaaaaatagaaagtaaaaaaagaaattaaagaaaaaatagtttttgttttccgaagat gtaa aagactctagggggatcgccaacaaatactaccttttatcttgctcttcctgctctcagg tatt aatgccgaattgtttcatcttgtctgtgtagaagaccacacacgaaaatcctgtgatttt acat tttacttatcgttaatcgaatgtatatctatttaatctgcttttcttgtctaataaatat atat gtaaagtacgctttttgttgaaattttttaaacctttgtttatttttttttcttcattcc gtaa ctcttctaccttctttatttactttctaaaatccaaatacaaaacataaaaataaataaa caca gagtaaattcccaaattattccatcattaaaagatacgaggcgcgtgtaagttacaggca agcg atccgtcagcttgcctcgtccccgccgggtcacccggccagcgacatggaggcccagaat accc tccttgacagtcttgacgtgcgcagctcaggggcatgatgtgactgtcgcccgtacattt agcc catacatccccatgtataatcatttgcatccatacattttgatggccgcacggcgcgaag caaa aattacggctcctcgctgcagacctgcgagcagggaaacgctcccctcacagacgcgttg aatt gtccccacgccgcgcccctgtagagaaatataaaaggttaggatttgccactgaggttct tctt tcatatacttccttttaaaatcttgctaggatacagttctcacatcacatccgaacataa acaa ccatgggtaaggaaaagactcacgtttcgaggccgcgattaaattccaacatggatgctg attt atatgggtataaatgggctcgcgataatgtcgggcaatcaggtgcgacaatctatcgatt gtat gggaagcccgatgcgccagagttgtttctgaaacatggcaaaggtagcgttgccaatgat gtta cagatgagatggtcagactaaactggctgacggaatttatgcctcttccgaccatcaagc attt tatccgtactcctgatgatgcatggttactcaccactgcgatccccggcaaaacagcatt ccag gtattagaagaatatcctgattcaggtgaaaatattgttgatgcgctggcagtgttcctg cgcc ggttgcattcgattcctgtttgtaattgtccttttaacagcgatcgcgtatttcgtctag ctca ggcgcaatcacgaatgaataacggtttggttgatgcgagtgattttgatgacgagcgtaa tggc tggcctgttgaacaagtctggaaagaaatgcataagcttttgccattctcaccggattca gtcg tcactcatggtgatttctcacttgataaccttatttttgacgaggggaaattaataggtt gtat tgatgttggacgagtcggaatcgcagaccgataccaggatcttgccatcctatggaactg cctc ggtgagttttctccttcattacagaaacggctttttcaaaaatatggtattgataatcct gata tgaataaattgcagtttcatttgatgctcgatgagtttttctaatcagtactgacaataa aaag attcttgttttcaagaacttgtcatttgtatagtttttttatattgtagttgttctattt taat caaatgttagcgtgatttatattttttttcgcctcgacatcatctgcccagatgcgaagt taag tgcgcagaaagtaatatcatgcgtcaatcgtatgtgaatgctggtcgctatactgccaga agag agaaagaaggaaagcggccgcacaggtttcccgactggaaagcgggcagtgagcgcaacg caat taatgtgagttagctcactcattaggcaccccaggctttacactttatgcttccggctcg tatg ttgtgtggaattgtgagcggacaacaatttcacacaggaaacagctatgaccatgattac gcca agctatttaggtgagactatagaatactcaagcttgcatgcgatacgtatcgttaacgat ggat ccgacgcacgtgcgaattcgccctatagtgagtcgtattacaattcactggccgtcgttt taca acgtcgtgactgggaaaaccctggcgtcacccaacttaatcgccttgcagcacatccccc tttc gccagctggcgtaatagcgaagaggcccgcaccgatcgcccttcccaacagttgcgcagc tgaa tggcgaatggcgcctgatgcggtattttctccttacggcggccgcttgacataacttcgt atag catacattatacgaagttatgtttaaacattagcagaaagtcaaaggcctccggtcggag gctt ttgactaaaacttcccttggggttatcattgggtcgagaccgcctgaagaggacttccat tgtt cattccacggacaaaaacagagaaaggaaacgacagaggccaaaaagctcgctttcagca cctg tcgtttcctttcttttcagagggtattttaaataaaaacattaagttatgacgaagaaga acgg aaacgccttaaaccggaaaattttcataaatagcgaaaacccgcgaggtcgccgccccgt aacc tgtcggatcaccggaaaggacccgtaaagtgataatgattatcatctacatatcacaacg tgcg tggaggccatcaaaccacgtcaaataatcaattatgacgcaggtatcgtattaattgatc tgca tcaacttaacgtaaaagcaacttcagacaatacaaatcagcgacactgaatacggggcaa cctc atgtcgcctgaagagtgagaccgtcccaactttcaccataatgaaataagatcactaccg ggcg tattttttgagttatcgagattttcaggagctaaggaagctaaaatggagaaaaaaatca ctgg atataccaccgttgatatatcccaatggcatcgtaaagaacattttgaggcatttcagtc agtt gctcaatgtacctataaccagaccgttcagctggatattacggcctttttaaagaccgta aaga aaaataagcacaagttttatccggcctttattcacattcttgcccgcctgatgaatgctc atcc ggaatttcgtatggcaatgaaagacggtgagctggtgatatgggatagtgttcacccttg ttac accgttttccatgagcaaactgaaacgttttcatcgctctggagtgaataccacgacgat ttcc ggcagtttctacacatatattcgcaagatgtggcgtgttacggtgaaaacctggcctatt tccc taaagggtttattgagaatatgtttttcgtctcagccaatccctgggtgagtttcaccag tttt gatttaaacgtggccaatatggacaacttcttcgcccccgttttcaccatgggcaaatat tata cgcaaggcgacaaggtgctgatgccgctggcgattcaggttcatcatgccgtttgtgatg gctt ccatgtcggcagaatgcttaatgaattacaacagtactgcgatgagtggcagggcggggc gtaa aaatgtaatcacctggctcaccttcgggtgggcctttcacacttgcatcggatgcagccc ggtg aacgtgccggcacggcctgggtaaccaggtattttgtccacataaccgtgcgcaaaatgt tgtg gataagcaggacacagcagcaatccacagcaggcatacaaccgcacaccgaggttactcc gttc tacaggttacgacgacatgtcaatacttgcccttgacaggcattgatggaatcgtagtct cacg ctgatagtctgatcgacaatacaagtgggaccgtggtcccagaccgataatcagaccgac aaca cgagtgggatcgtggtcccagactaataatcagaccgacgatacgagtgggaccgtggtc ccag actaataatcagaccgacgatacgagtgggaccgtggttccagactaataatcagaccga cgat acgagtgggaccgtggtcccagactaataatcagaccgacgatacgagtgggaccatggt ccca gactaataatcagaccgacgatacgagtgggaccgtggtcccagtctgattatcagaccg acga tacgagtggtaccgtggtcccagactaataatcagaccgacgatacgagtgggaccgtgg tccc agactaataatcagaccgacgatacgagtgggaccgtggtcccagtctgattatcagacc gacg atacaagtggaacagtgggcccagagagaatattcaggccagttatgctttctggcctgt aaca aaggacattaagtaaagacagataaacgtagactaaaacgtggtcgcatcagggtgctgg cttt tcaagttccttaagaatggcctcaattttctctatacactcagttggaacacgagacctg tcca ggttaagcaccattttatcgcccttatacaatactgtcgctccaggagcaaactgatgtc gtga gcttaaactagttcttgatgcagatgacgttttaagcacagaagttaaaagagtgataac ttct tcaacttcaaatatcaccccagcttttttctgctcatgaaggttagatgcctgctgctta agta attcctctttatctgtaaaggctttttgaagtgcatcacctgaccgggcagatagttcac cggg gtgagaaaaaagagcgacaactgatttaggcaatttggcggtgttgatacagcgggtaat aatc ttacgtgaaatattttccgcatcagccagcgcagaaatatttccagcaaattcattctgc aatc ggcttgcataacgctgaccacgttcataagcacttgttgggcgataatcgttacccaatc tgga taatgcagccatctgctcatcatccagctcgccaaccagaacacgataatcactttcggt aagt gcagcagctttacgacggcgactcccatcggcaatttctatgacaccagatactcttcga ccga acgccggtgtctgttgaccagtcagtagaaaagaagggatgagatcatccagtgcgtcct cagt aagcagctcctggtcacgttcattacctgaccatacccgagaggtcttctcaacactatc accc cggagcacttcaagagtaaacttcacatcccgaccacatacaggcaaagtaatggcatta ccgc gagccattactcctacgcgcgcaattaacgaatccaccatcggggcagctggtgtcgata acga agtatcttcaaccggttgagtattgagcgtatgttttggaataacaggcgcacgcttcat tatc taatctcccagcgtggtttaatcagacgatcgaaaatttcattgcagacaggttcccaaa taga aagagcatttctccaggcaccagttgaagagcgttgatcaatggcctgttcaaaaacagt tctc atccggatctgacctttaccaacttcatccgtttcacgtacaacattttttagaaccatg cttc cccaggcatcccgaatttgctcctccatccacggggactgagagccattactattgctgt attt ggtaagcaaaatacgtacatcaggctcgaaccctttaagatcaacgttcttgagcagatc acga agcatatcgaaaaactgcagtgcggaggtgtagtcaaacaactcagcaggcgtgggaaca atca gcacatcagcagcacatacgacattaatcgtgccgatacccaggttaggcgcgctgtcaa taac tatgacatcatagtcatgagcaacagtttcaatggccagtcggagcatcaggtgtggatc ggtg ggcagtttaccttcatcaaatttgcccattaactcagtttcaatacggtgcagagccaga cagg aaggaataatgtcaagccccggccagcaagtgggctttattgcataagtgacatcgtcct tttc cccaagatagaaaggcaggagagtgtcttctgcatgaatatgaagatctggtacccatcc gtga tacattgaggctgttccctgggggtcgttaccttccacgagcaaaacacgtagccccttc agag ccagatcctgagcaagatgaacagaaactgaggttttgtaaacgccacctttatgggcag caac cccgatcaccggtggaaatacctcttcagcacgtcgcaatcgcgtaccaaacacatcacg cata tgattaatttgttcaattgtataaccaacacgttgctcaacccgtcctcgaatttccata tccg ggtgcggtagtcgccctgctttctcggcatctctgatagcctgagaagaaaccccaacta aatc cgctgcttcacctattctccagcgccgggttattttcctcgcttccgggctgtcatcatt aaac tgtgcaatggcgatagccttcgtcatttcatgaccagcgtttatgcactggttaagtgtt tcca tgagtttcattctgaacatcctttaatcattgctttgcgtttttttattaaatcttgcaa ttta ctgcaaagcaacgacaaaatcgcaaagtcatcaaaaaaccgcaaagttgtttaaaataag agca acactacaaaaggagataagaagagcacatacctcagtcacttattatcactagcgctcg ccgc agccgtgtaatcgagcatagcgagcgaactggcgaggaagcaaagaagaactgttctgtc agat agctcttacgctcagcgcaagaagaaatatccaccgtgggaaaaactccaggtagaggta caca cgcggatagccaattcagagtaataaactgtgataatcaaccctcatcaatgatgacgaa ctaa cccccgatatcaagtcacatgacgaagggaaagagaaggaaatcaactgtgacaaactgc cctc aaatttggcttccttaaaaattacagttcaaaaagtatgagaaaatccatgcaggctgaa ggaa acagcaaaactgtgacaaattgccctcagtaggtcagaacaaatgtgacgaaccaccctc aaat ctgtgacagataaccctcagactatcctgtcgtcatggaagtgatatcgcggaaggaaaa tacg atatgagtcgtctggcggcctttctttttctcaatgtatgagaggcgcattggagttctg ctgt tgatctcattaacacagacctgcaggaagcggcggcggaagtcaggcatacgctggtaac tttg aggcagctggtaacgctctatgatccagtcgattttcagagagacgatgcctgagccatc cggc ttacgatactgacacagggattcgtataaacgcatggcatacggattggtgatttctttt gttt cactaagccgaaactgcgtaaaccggttctgtaacccgataaagaagggaatgagatatg ggtt gatatgtacactgtaaagccctctggatggactgtgcgcacgtttgataaaccaaggaaa agat tcatagcctttttcatcgccggcatcctcttcagggcgataaaaaaccacttccttcccc gcga aactcttcaatgcctgccgtatatccttactggcttccgcagaggtcaatccgaatattt cagc atatttagcaacatggatctcgcagataccgtcatgttcctgtagggtgccatcagattt tctg atctggtcaacgaacagatacagcatacgtttttgatcccgggagagactatatgccgcc tcag tgaggtcgtttgactggacgattcgcgggctatttttacgtttcttgtgattgataaccg ctgt ttccgccatgacagatccatgtgaagtgtgacaagtttttagattgtcacactaaataaa aaag agtcaataagcagggataactttgtgaaaaaacagcttcttctgagggcaatttgccaca gggt taagggcaatttgtcacagacaggactgtcatttgagggtgatttgtcacactgaaaggg caat ttgtcacaacaccttctctagaaccagcatggataaaggccaacaaggcgctctaaaaaa gaag atctaaaaactataaaaaaaaaataattataaaaatatccccgtggataagtggataacc ccaa gggaagttttttcaggcatcgtgtgtaagcagaatatataagtgctgttccctggtgctt cctc gctcactcgaccgggagggttcgagaaggggggtaccccccttcggcgtgcgcggtcacg cgca cagggcgcagccctggttaaaaacaaggtttataaatattggtttaaaagcaggttaaaa gaca ggttagcggtggccgaaaaacgggcggaaacccttgcaaatgctggattttctgcctgtg gaca gcccctcaaatgtcaataggtgcgcccctcatctgtcagcactctgcccctcaagtgtca agga tcgcgcccctcatctgtcagtagtcgcgcccctcaagtgtcaataccgcagggcacttat cccc aggcttgtccacatcatctgtgggaaactcgcgtaaaatcaggcgttttcgccgatttgc gagg ctggccagctccacgtcgccggccgaaatcgagcctgcccctcatctgtcaacgccgcgc cggg tgagtcggcccctcaagtgtcaacgtccgcccctcatctgtcagtgagggccaagttttc cgcg aggtatccacaacgccggcggtcggccgcggtgtctcgcacacggcttcgacggcgtttc tggc gcgtttgcagggccatagacggccgccagcccagcggcgagggcaatcagcccggtgagc gtcg gaaaaggaatattcagcaatttgcccgtgccgaagaaaggcccacccgtgaaggtgagcc agtg agttgattgctacgtaaataacttcgtatagcatacattatacgaagttatggactacgc aggt caatatccggaacatgaaacccgcaggttctgaaatccgcatattcagaacatggggatt cggg aagcgcagcaatacgggcagtctcaggttcgatgctccggtcaggaaatgggaatacaga gaac cgaatccgttatatgacggttacaccacccgtaactggttccgctatcatatcatgaaac accg ggacagggaaaggacaggcgaatacaccttccgcagcgattcattcacgctgtacagccg gagc gagctggacgagctggccgcaatcctgaaaggcagactctacaagggaatcctgcctgac tctc ttgtactttggggataccgcatggatattaaggaaatatcacgtgaacagtggaacggta tggg acagcacggacaaatccgcatgaaattcatgggatacggtccggtcagaatccacacgga caat gaaaaccataccgtaacagtatacagaatcaacgacatattgtcttcaactatcagaatt ttca tattttttcagttctttttttgtttcttctattaatattttaagccactccatgatttgt attg catgttcatgaacagtttcattttggctatcactgtcgtgtagtagcctttgaaaatcac gtaa aatattgtctttcccaagcatctcccatacaggcatcatccggtggattatttttctcat ggtc tcacggtcggttatcctgtcagcagattccatctcctccagttctttttcagattccata acaa cgagagaaagcatatgactataatcatccgtattctccagtaaactggaaaaatcgaatt ctcc ggaaactgaaacttgtgtacgagatataatggtggataaaaaagcaagcagtccgtggat attg aacggtttatgaatacagcctacaaatccttctttttcataaattccggaatttccgtca ccac gggcagtcatgactgctactggaacagttctagaattgccgatgtccgaattgcgaagca atct taacaaaccgaatccgtcagtatcaggcatttgtacatctgtcaagatcaaatcatattc agaa ttttcaagagcggccactacttcacgtgcattcttacaggttttacaggatatacctttg cgcc cgagcatatcttccgctattttcagttgtataggatcatcgtccactacaagaacattct tagg caatatagttattgtattatggtccgatttgtcttcctcaactaactcatccgtttcagg caaa gaaagttccagtctgaacatgcttcctttaccgagtacactttctacatccatttttcct tcca aaaccttaattaatcctttggtaaggaaaagtcccaaaccaaacccttcagaattgacat tctg tgcggcacgctcaaatggagcaaatattcttttcagtgtttcctcatccataccgatacc agta tcccttatttcaatacgaagttttccttctgaatattctgaatggaaattgacgttaccc ctgg aagtaaacttaatagcgtttgtaagtagattggctaaaacctgttcaagtttgtccgcat cacc ttttactattacatttgatcctttatgttcagaatataaaatcagaccttttgaagtcgc ttta cgagaaaactcatctgaaattcgttgcaagaaacggtcaagataaaatggtgtgtcgtta cgca aattaccggcttcattgattcggtaagcatccatcaaatcattaaccagatgtaaaacgt gtcg acaagaatgacggatgtcatctaaatatttttcgcgcttcctcttttcacgcgtttcaga tacc aaatctgcacagttatggatattaccaagtggacctctaatatcatgagaaactgtcagg atga ttttcttacgcatatcaagcaaattctcgttttcttgaatagcttgttgtaatttaaatt taat tatttcttccttacgtaaatctgattgtataattaaaaatgaaattaatattataaaaac cgca atactcatcattacgataaataatcgaaaggattcttgtttgacttccgttacctctaag tttc gttctataaatgacagctgtacctgattatctaaaaaagatacaaaatcatataattttt gatt taacagcctattctgcaaacgcaagctatccacataagtttctatctgattgtttcgcat atct atgacagaaaccaatctattattaaaattctgtatttcattagttatataggggacttgt atcg tctccttctttccgaataatccggcaattcctttctttttctgagttattgtcttcactt ttac tgtttgagtagctattacaggcaattcattagtaagaatactatcagatttattcgcaaa ttgg actgctttcattatttgaaacaagtgcatttctttcgttttaagcaattcccgtaaagaa tcaa tttgaactggacataaaaaatcacaactccttaattttatttcaagtagaacactatctg tttt aaaacgttgattatgaaatatgttataatcagactcatcccatactataactgattcgcc taaa gttgccaacttagtaatatacaaatgaactttattagtattctcataagcttcattaatt tgaa ttatcagattctcaagttctttcaaccggcaacgttcatttatcattacagtaaccatac ttaa gactataaatcctgtaataaaatatccaataaatagtcttttgcgtaataatgaagtcat cagg aacattctattgatttatttgacatcataattctatatatttaactagtcatagtatata tcat tctcaaatatttatttcaaattcaagcaataaaataaaaaaacacttcatattacaactg aact cttttatgaaaaagttgaatatatgaagtgtttttttattacgatataaactataaaatc ctat tcttcgggaactggtgtataaacccttatccagtccaccaggaaggtgtggtcttccaca tttt tcagttcctcatccgtagggcttaaacctttaacggctctccagctttggtcttccatat ttat tatgatgtccatgtcttttaccagacctgtaccaccagtgtagttgttggggtcgataat atcc ttgccgcttacggttctgacaagttctccatctacataatattcaagtgtgaaagggtct ttcc agaacactcctacacgatgaaaatcgtcgcgccacaatgttcccttgtcatccttatacc atga gccaagatctttcggctgataatccttgaatggctggcggatgaatatgtgatggctcag gtga agtctgtcggcaccgtaacctccgccgtctctgtcgccgccgtatgcttctatgatgtcg attt cctgagtatcgtcagggctgagcatccatacatcggatgccatggttgaatttgaaagtt ttgc gtatgcctctacataaaccggatactttacacgtgtcttcgatgtgatacatcccgtata ggtt cccggcagttcctttgtgttgggtccgcttacaactttcttcatggggacatcttcagga cggc tggctcttattttaaggtatccgtcggaaacggaaacatggtctctctgccatattgtag gagc aggtcctgtccaatgattatgatagaaatcggtccatttggcatagaactcttttccttt atcc ttttcgtcggcaacataattaaagtcgtccgactgtggatggagtttccacaccataccg tcgc cggcatcagcgggtacaggatagatatcccactcgtacgatttattattgaaatcttctg ctgc acaggctatttgcagcgatgctaaacaaatggtaaacagttttctcatcgtggtatctta gttt aagttataataattattttcgttcttttgattcacctttagcggtatgtgtctgcaatgt ccag gtagaaaatctcattatgctctgatagtctgaactgttgtatatatgagtaagaccccat ctca atatttcggtaggttctttttcggcatctgcactgcggttcaggccaatggcgtgtggcg cgcc ttttactactgacattatttcaaagtttattccgtcaggcgaccactggagtgtgttctt ttca ggaccgtcggtggtgataagtgaagctatacctcctttgtaaggccatacgcaaacttca tgcc cgctgtttgaaataggattatattccgatttcacatacggacccataggattttccgcaa tagc cactccgtgtttgatttcacggccgccccatgttatttcttctcccatacgttcgccttt gtag tacatatagaacttacctttataaggtattatacacgggtcgtgtaccttatgactgtcg aaat cacctttcgacactaccttgaatctgttatcctcatcgccttcccattcgccggtattag aagg ttccagtacaggcttgtctgtcttgatccacggtccttcaggggaatcagcacatgccat accg atagtattctttacacggactgtgtaaggggattttaccgcctgatagcaaagataatac tttc ctttccattccatcacctcaggagtgaagactgaacggtcgtcgtaagcacctttttcac cacg tttcactgcaattccctgttccttccatgtccatccgtcttttgatgtggcataccatat atca catctgtcccatgggaaaaccttatctttctctatatctccagcaaatccttgggtaggt ccat agctctttgaataccatacataatatgtattacctattttcagcattgcactcgggtctc ttct tactacgccctcttcataagcaagatcacctttaagtggttccatcttatactcaaagaa ccat ttattgtcgtgattttcccatttcatggcacgtttcatagctgcacttaacttatttccc ttag gtattcccaatgaatcggccttacgctcatcataattctgagtgtcgtcaacggcaatag tctg tgtattgcctgtatttccgcatgctgccaatagcgacatcatgccggctgcaagaataat tttt ctcatactagactttattttatattaattgttagtttattcgagtgtaattcacttgttt ctgc actgatattcagtaccgatgatttttctgtcgactgaagcatcagcatacatcttccctg atat gtcataatatccttactttgatatggagaaacgttcttcacgtttccattgtctatacca agca gacggtactctccatcaatgttgaacttaagcatctgttctgttgtctttacaggattac cttt tttgtctgttagctgagctgtgacatgcagaacatcctttccatttgctgcgatactttg tttg tcaaccgtcagcaatatcgaatgttctttgcctgaagtccttatagctgtagtggtatta ccta acttattttttccttttgcggtaatagtgccaggcttgtactgaactgcccatttataga tatg atcctcaaaatcgtctatatacttctttcccatcgacttaccgttaacgaaaagttccac ttca tcacaattggaatatatctctactattaccgagtcacctttctgataattccagtgagag ttta catcatcccaaacccataattttctatcccattcatgtcctttcttatcagtaaatccat cttt tacatggagatacgaagatttgtctgtagtctgtgaatatatagcaataaaaggcttgtc tgtc cacaatgatttcatcatgtcgtacgaaggcttcacatagccgcacatatccaggagacca catc ctatcgacttttgaggccattttgaaagacggctttcactttctcccagataatcgactc ctgt ccatataaacatacccggaacgaaatccctttcaatcaccgccttccattcgtgccactg accg agattttctgtacccattataggcttgtcaggataattcttcttagcataatcatacatc acgc gacggtagctgaagcctgccacatcgagcgcgtcgatatatcctgactcaaagcttatgg aagg caggatgcagttggcggtaactacacgtgtggtgtccatctggcgtgtccatgcagctaa tttt tgcgctgtacggccaatgtcgtatgcatgtttaggctggattttccacatttctctgatt tttt ctttagagtatggaggctgattccagaaataattaccgttggaatcggcaccgaagaaac ctgt cgcctcgcggcatccggtataagtccattctatttcattacctatactccactggaagat acag gcatgattacggcttctcctcattacgtttttcaaatctctttctgcccattcctggaaa tgct cgcaatagccatgcgtaggatagtcttctacagtttccttcatattgagtcttttatctt tggg ataatcccactcatcgaagaattcttcctgaaccagaagacctatctcatcgcacaaaga caga aactcttccgctcccggattgtgcgagaggcggatggcattgcatcctccttcctttagg gttt tcagacgccggtaccacacatcgcgtatcattgccgcgccaaccattccggcatcatggt gcag gcatactccttttatcttcatgtttttcccgttaaggaagaaacctttgtctgcatcaaa acgg aatgtccgtatgccgaacctgacagtgttttcagaaattacttcatcgccattcttgatg cgtg tctcggctgtatagaggacaggtgtatcgacgctccacaaatcaggctgtttaatctcag atac gatgtcgataattttctcctcaccagcattcagttttatactgaagacctcaaaggctgc gata ttgcctttattatccttatatactacctcaacaactgcagctctgggttcggagtagctg ttgc acacggtaacctggttgtttactttagcatatttatcagtaaccacgggagtagtgacaa atgt tccccaaaccggaatatgcagtctgtcggttacaatcattttcacatccctgtatatacc tgaa ccggtgtaccatctgctgtcggcataatggctgtggtcgacccttacagtcatacggtta tcct cattgggattgagatagtctgtgacatcaaaataaaaaggagcatatcccgaaggatgat atcc aagctttttgccatttatccaatactcagaattattatatactccatcgaacactatata gcat ttctgatttgcactgattgttgtgggaaatgatttgctataccatcctattcctccctga agga aagctacacatccttcacccgaaatggaatcgtaaggtaaaccaacactccagtcatgtg gcag gttcactttcttccattcatcaccagggacataagaagtatatgaataatgagcagaatc tttc agtacgaatttccaatctttattgaaatcaacatttgaatcagatgctgaaacctttagg gttg ataataggattattaaagctaaaagatttttatttctcataatcttaggttttacatgtt tttt gatgtcacaaaactatatctttcacttataatatatgagggggatattaatgtgatatag ggtg ggaaatcagaattttacatctgccctgtattccaccgtcacctacaaccttgacaaagga tgtt cctttcttccctcttatggttctcaggacaaacagacactttccgttatatgtccttaca ctat tgtttatgacgttgatgttcaaatcttctatcgaaggcgatccattgtcgagtccggcaa gttc aagcttgtcgtcgaggattatcctcacatccgaaggtatatcgactactgtgtttccttc ttta tcttcaatggatacttctacatggataaggtcataaccgttgtcggtagctgttttgcgg tcgc agttcagtgccagacggcacggcttgccgcttgtggacaaagtgtctttcgacaatattc tgtc gccgtccttgcctaccgcaaggagtgttccttccttgtatgccaccttccacatcagtat atta tgctccatgaaatcgctgcgtttctttgttcccaacgatttgccgttcagaaacagttcc actt ctggggcgttggtatatacctgcaccagtatgtcctcgtccctgcggtacttccatttat cgcg tgtgtcgtaccactcccagcgtctgatccatcccgggcgtggagtgtaggtgaaacttcc gtca gtatccatcttgaactcgctttccttttcaggtattgttacaatatgggttttcggtgtg tctt tccacagacattcaaagaaatggccacgcgctgtcttgttgcccacgaaatcgaagaaag aaca gtctccaccccttgcaggccatgggccgttctcgccaagatagtcgaatcctgtccacac gaag atgcccgctatgtacttcttgtcggccacggctgtccattcaaagagctgaccaacattc tccg aaccgataataggctgatatggatatagcttatggtcgatttcataatatttgtctttat agtt atatcccactacatcaagaacgtctgtatatccggagagacgcgaaactgacggaacaac gact cctgaagagacgggacgggtagtgtccacatccttaacccaaccggcaaggacagcggct gttt cagccaaatcgtcttttcctcctgacagacggttgaactctttcagtatagacttgttgt ctgt ttccgggtcgcccgtatggataagacccttgaaccctttattgtctttgctcgatgccca gtaa tatggataggtccattctatttcattgcctatactccagagtatcacgcaaggatgattt ctgt ctcgcctgatgaacgacttgaggtcgtgctcggcatgcgtatcgaagtatctggtatatc ctat tgatatgctgtcgggcgcatcttccttagctcgctcagtaatccactttttctttgccac cttc cattcgtcgataaattcattcattacaagaagtcccagactgtcgcacatttccagcaga cttt ccgaatgcggattatgggctgtacgtatggcattgcagcctatggaacgaagtttcagaa ggcg tcgcaacagggcatcatcgtatgcggcaacacccatacatcccaagtcgtggtgtatgtt cact ccttttatttttactgattttccgtttagaaggaagccttcatccgcatcgaatttaatg tcgc ggataccaaattttgttgttttcttatccatcacatatccgtcagaagcaatcagagtag tatg aagctcatacatcgaaggcgtttcaagactccagagatgacaattctccagttcaacaga tgca gtgaactcattgaaatcgcctttcagggcaacaaaatcatcggaaacagaagctattgtc ttgc cgtcgtacactacttcgtgcttcacggtgactccttttacacctgttccagcattcttca cctc gcataccacattcaccatcgaacggttgcctacctgtggtgtggtaacgaatattccgtc tgaa ggaatatagagctcgtttcttagaataagactcacattcctgtatataccggcaccgaca tacc atctgctatcggcatacgctcttctgtcaacgcagacagttattgtattcatcgaacctt ttgg tttcagatattgagtaagttcatattcaaatcccacatatccgttaggacggaatcccaa cata tgcccgtttatccaaacctttgagttattatatacaccttcgaaatgaatgaacactttt ttcc cattcatatcatccgaggtgagaaaattcttcatgtaaatccccacaccgccagacagaa aacc attgcttccggctgtctgagtcttggtatatccttcgctgatactccagtcatgaggcag acac acatcctcccactttatatctggactcaggaacaaagtgtcctgaggcacgaaacctgct ggtt tgctgaatttccaatcgaagttgaaatccactttagtggaggttccggcataacagaatc cgga cagaaagatagttaagactgtgataatgttttttatggtcatatcgattttcagattaat atta atgacaaaaataatttcaaaagtgtaaaaacaaaaaaactctccatttatatttcagata tcaa cggagagtttcatcattaaaaaaaataaaacattttataaagttactccttgcttaagga tagc tatttcccggtatcccttcttttcgttcagtgcctgctttccgcttgccacttccaccac aaag tctataaaacgtctgcttaaagattccatgctttctccctctaccagagttccggcattg aaat caatccacgtatgtttctgttcataaagcggagtgttggtcgaaaccttcacggttggaa cgaa tgttccgaacggtgttccgcggcctgttgtgaacagcacgatatggcatccggcagaagc aaga gccgtacttgccactaggtcgttgcctggtgcgctcaacaggttaagtccgtgtgttgtg acac ggtcgccatatttcagaacatcctccaccatcgagcttcccgacttctgtgtacatccca atga tttctcctcaagcgtggaaatacctcccgccttgtttcccggtgaaggattttcatatat tggc tggtcgttgcggatgaagtagttcttgaagtcgtttatcatggccactgtgtcgtcgaat atct ccttcgtgcggcaacggttcatgagcagtgtctcggctccgaacatttcaggtacctccg tgag gactgttgtcccaccctgggcaacaagatagtcagagaacaccccaagcatcggattggc cgtg ataccggacagtccatcagacccgccgcacttgagtcctatacgcagttttgacaggggg acat cagtccgcttgtcttccctggctatggcatacatctcacggagaagtttcataccctctt ctat ctcatcatctactttctgagaaacaaggaaacggatcctttgggtatcatagtcacctat aaac tcacgaaaggcatcaggctggttgttctcacagccaagacctacgacaaggacagctccg gcat tgggatgaaggaccatgtcacgcaatatcttacgggtgttctcatggtcgtcacccaact gcga gcatccgtagttatgagggaaagatataatggagtcaaccccctcgcaacctgtttcctt gcga agctgctcggccaactggtttactattccgttcacgcaacccaccgtagggataatccat atct cattacgtatgccggcttctccgttagcacgcaaataccctttgaatgtatggttctcgt tcgt gaatgtctgtttctcgaacttcggagtgtaagtgtatgtactcagaccggaaaggttcgt cttg acggttttctcgttcagcagatgtcctttcctgacttcctttacagcgtgcgatatgggg aaac cgtattttatcaccatatcaccttctgcaaaatccttcagggcaatcttatgaccggcag gtat atcctccattaattctatggaattgccgttcacctctattacagtccctttggacaatgg gtgc agtgccacagccacattgtccgcagggtttatctggatatattcagtcataacaaactaa catt tataaattgaagaatacaggtagaagtatcaacctacaaggtcttttactgtctgaagca ttcc ttcgctctggattttgttgatatagtaaattacacggtctgccagtcccgagatagtatt aagg tcttcaccccaaatggaagtatcggcgagaactgtcttcacaagattttctaccgagcca tcgt tccacaaacttgtaagcatcgccatgatttcctgtgcatcgttaggaactatctctacac catc ggcacgctttccacctttgtagtatactatgatggctgcaagaccgagtacaagtccttc agga agcacacccttacgtttcagatattccttcactcctggaaggtcgcgtgtggcatactta ggga atgagttaagcatgattgatgttacctgatggtctacgaaaggattattgaaacgttcca ggac atcatcggcaaacttcttgagttcctctttcggcaggttgagggtctccatcagctcgtc gaac atcacacgtttgatgaacttgcctatcacctcatgttggcatgcgtctctcacgatattg acgc ccgaaaggaatgccaccggcgacaatacagtgtgaggaccgttcagcagagtaaccttgc gttc atgataaggctcctccgacgggacgaacagaacgttcagtcccgccttgtttgcaggaaa ttct tcggcaaccgattccggtgcttcgataacccacagatgaaaagcctcgccctgtacaact aaat tgtcatcaaagtatagtttagtttttatgttgtctatgtctttacgagggaaacccggta cgat acggtccaccagtgtggcatatacaccacatgcagtttcaaaccatgacttgaactcttc gcca aggttccacaattcaatatactgatagattgtttccttcagtttgtgaccgttgaggaag ataa gctcgcatgggaagatgatgagtcctttcgacttgtcaccgttgaaatgtttgaatctgt gata aagcaactgtgtcagcttgcccggataagagcttgcaggagcatcctcaagcttgcacga cgga tcgaagttgataccggcctcagtagtgttcgagattacgaatctcatatcaggctgttcc gcca gtgccatgaagtcattatactggctgtatggattcagcgcgcggctgatgacatcaatca ttct gaatgagttcaccacctcgccattgttcagtccctgaagattgacatgatacagacagtc ctgg gcattgagggcatcaaccatacctttttctataggctgcaccacaacaacactgctgttg aaat ctgtcttttcattcatattcgagataatccagtcgacaaacgcacgaaggaaattacctt cgcc aaactgtatgatacgttccggacgtactgcctttactgcagtcttactatttaaagcttt catt gtaatgccaaaaaattaaaattgataagattaaaattcaaccaacattctgaatacctta cctg gattttccgaccatttctgcagagcctcgcctgcctcttcaggtttcactacggcagaga taag ttcgttcatcgggcagttgccattctgaagataatgtatcacggcacggaaatcctcagg catt gcattgcgcgaaccgcgtatgtcgagttccttctggacaaaatattttgtctggaaagcc actt cactcttggcatagccgatacatgccacacggcctgtgaaacctacaatgtcgatggcag taac atatgtgataggactacccacagcctctatcaccacatcagccatatagccgtcagtaag ttcc cttactctttccaccacattttcagtcttcgaattgataaccatcgaagcacccaggcgt tttg ccagttcaagcttctcatcgtcaatatccaatgctattacccttgcgccacgaagcgatg ctct tactatggcgccaagtccaatcattccgcaaccaatcacggccacagtatcaatgtcagt tacc tgagctctcgacacggcatggaaacctacgctcataggctcaatcagcgcacattcctta tccg aaagaccggcagccggaataacctttgtccaagggaggacaaggaactcctgcatagaac cgtt acgctgaacacccaaagtctcgttgtgttcgcaggcattcacacgtccgttgcggcatga agca cactttccgcagttggtatatggatttactgtcacgttcattcccttctcgaaaccgaca ggaa cgccttcgcctatttcctctatcacagcacccacttcatgtcccgggatgacaggcatct tcac cataggatttcttcccaggtaagtattaaggtcggaaccacagaatccgacatatttgat acga agtaaaatttctccggctccaagtgttggtttaactatatcagctacttgaacctttccg gctt cagtaatttgtacagctttcataatctatgtatttatttaaatttgttattgtattattt tgat gttgcattaattcaatgttgttttttctctatcttatatcctctccagccataatatgcc gtaa agaagaaacatatcagaggtattacatatgccacctgatagaagtccgcgttatgattca tcac aaatgcggtgaactgagggatgcacgcattacctataatagccatcacaaggaatgccga acca ctctttgtgtcctcgccaaggtcgcgtagtgcaagtgagaactgggttggatacattatc gaca tgaagaacgacactgcaagcatggcataaagtcctgtcataccaccgaacatgataatta ctcc acacagtatgatatttactatagcgtatgtaagcagcatatcctgaggtctgaatttcga catt agcatagtacctatccatctgccgccaaggaaagccagcatatacagtccgaagaatgtg gtcg cctcatcctccgacagacctgcatacatgcagcagtaaactaggaacaggctgttgatgg ctgt ctgccctccgttatagaagaactgtgcgataactccccatctcaggtgtttgcgtttcaa cact gcaaaattgataagcttgcccttctcgccgtgcgattcctccttgtcaatatcaggcaac ttat acagtgcaaacaccacagcaagaataatcagcaggactgcaagaaccagataaggcatct tcat ggagtctgtctccatctgaataaatccgtcccaacctccgggaaagtcggcaggcagagt ctcg cgagtatagttctgtccggtaagtataagcttactcagaaacattgcggatatgaaagca ccaa gaccgttgaacgactgtgcaagattcagtcttcttgaagccgtatcgtgtgtacccagag ctgt cacatacggattggcagcagtttcgaggaagcacattcccgttgccatgatgaagaagat taca agatatgcccagtattcctttatctcggctgcagggaagaaaagcagaccaccgatggct gcaa gaatgagaccgacaattatacccgacttatagctgaaacgtttcatgaacattgctatcg gtat gggaaacaggaagtaggccagccaataggcagcttcagtgaacgaggcctcaaaagcatt cagt tcacaggttttcatcaactgcctgatcattgtaggcaatagattactgctgatagcccac atga agaacaagctgaatatcagtaaaagcggtataaaatatttgtttttcattctgacatgtt ttta atataaggtaactcaggcagattcttgaaaccgtaaaaggctttcgcgttctcgcccaag aaaa gttttttgcttctctcttccaattcttttgatttaatcacaaagtcgtacgacatcttgt aggt aatggctgtgattgtgcgtggatagtcggaaccccacatcagtttctcgaagccaacaag gtcg gcagcttcgttgatggctctgacagcgctgcggaacggatagaactcgtcattgaacagc caag tgataccgcccgactcaatcatcacattcttatgacgggcaagcattatctgcttcttcc aatc cggtttagtcaccataccgaaatgcccgatggcaatcttcaagtacggacattctgaaat gatt tcttccatctcgcccacctggaggtctccctctgccatatctatggaaagaatcaccccc ttgt cttccattagatgaaacatcctcatcatctcgtccgagttgagcatcaccctaccgtcct tcag ttgcaggcggtgtcccggaatctttatggccttgaaccctttgtctataagttcaaccgc ctgg ttatagaaacccggttttctgaattcacacataccacacacgaagaacctgtccggatat ttcg tcatcacctccatcagatagtcattctgaatgccgtcgatatactcctgtgtgacaacag ccgc gccaatcagggcataattcatattagccaggaaaacctcagccgtgtttcttccgtcaat cata aagggggggggagcatttgtctcacctcccccataaacaatgattgaccgttctctgtag tctt gattttcaggccatctacttcagtgtcctgataaagccacagatgcgaatgggcgtcaat tatt gtataatccatagaaacagtatttatgaatttgcccaacttactctttgctgatcgccta ttat ctccttaaccttttccacaaggctccagtctatcggttcctcaatgtattttatgttctg aagc acagactctgttcttgccgagctgaacaatgttgtaggtattctcggattgcttacagag aact gcaccgcaagtttctcgatagggtatccctgttcagcacaatacttggcagcctttgcac acac ctcaatcaatggttttggagccggatgccattcaggaacacctctatgtgtgagaagtcc cata ccgaacggcgaagcgtttatcactcccacaccattttcgtcaaaatagtcgaggaagtcc acca gcttgtcgtcgttcaatgaatagtgacagaagttaagcaccgcctctactgtacccggag cggc atggtcgataatccatttcaggttttcgagctgcaggtcggtgatacccacgtggcccac cacg cctttcttcttcagttccaccagagcaggcaatgtctcgttcaccacctggttcatatcc gaga actcaacgtcgtgaacgttgataaggtcgatatagtcgatgttcagacgttccatacttt cgta aacactctcctgagcgcgtttgtccgagtagtcccacgtattcacaccgtccttgccata gcgt cccacctttgtagaaaggatgaacgattctcttggcaattccttcagagccttacccaat acgg tttcggctttataatgtccgtaatatggagaaacatcaataaagttcagtccgcgttcca ctgc tgtaaaaacagactgtatagcgtcactttctttgatagaatgaaaaactccgcccaatga agat gcgccataactcaatacaggaaccttaagtcctgtctttcccaattcacgatattccatt tttg ataaataatttaaaggttaatattttttactctgtttattcttattcatacagatagaac atac gttccatcatcttccatttctcgtccgatgtggccccctcggcacactgctggaatttgg ctac gtattcttcccattcggcctgacgcggcagagtggcaagctttgccatagctgtatccca gtca aaatccagaggtgtttccactatcataaagagttttgaccccaatatgtatatttccatt tcca ggattcccacctcgcgtattccggcgcgtatctcaggccatgcctcttccttactgtgag cctt tctgtaggcttcaatcaattccggattctcacgcagactcaatgtctgacagtatctctt caca ggcagggaataacttttcactttatatccttctgtcttcatgatattattgatattaata tgtt agtattacatgtcactgtctttatcttttcgacgatgctaaagtatgaagtatccatcaa aaca atagaggagattttcaaaaaagaaagaggggatattataccccctctttttcgacatttt tacc cctcataaaggagataaaaagtcaccccaaactctataaaaaatcaaaacagattgaact gcat tcctgtgtagaaaaatccctggttggatttcggattccaatacgtcatcaccgtcaacgg gatt tcatattccataatccgaagtttataaatcacattcagggacacctgagtaattcctgcc gatt cggcatacatggttctgttcaccatttccccgctttcatttcttgaatttctcaatgcga aagc tgttccaataccaggaccgacccttagcttttcgttctgatagatggtatagcccacata tacg aaactggagtagatgttcttgctgttgtccagatccctgtcgcgaccgtaaacaagtgta gaga agctcaactccagcggaaatttcctgtcgcccgtataattgaccatgagatcaacgaaac gtcc agtttcatcaggcttatagttgaagaactccttattattatatgtagccccgggcgagaa atta tatgtatctatagcctttatctgaaacctgccatgagtatatgctatatactggctcagc tcct tataactccccctggtgttcgatccgccaaggaaaccggcggtaaacctccccgatgggt cgga aaccgacaaatcggacgagagaatcagtccgtcggccacttcaatgccacgccatagaat catg ttctgtagagtagtactgaaatgaagctgagcctgaacatttgctgacaaaaatataaat acag gaattaacagtcgctttttatacttacaggtatccaatgataatatatgtatcatactca gagc agtagaaaatcggttttaaattattattatggatttatttgtcgaaatactctataagat tata aacattccagttaatatccgacatgtatttggtcaatgatgtataaggtttatagttata atcg agcatacctttattgcaatcctcatcatccagatacttgaagaaaacccatcctacacaa ttct tggcttcgagcagtcccaaggtaaaatgctggtaagcgaatccacggttttgctggtcgc gtac cacgaaaccagctccacttgaattgtcaagcttagtatcctcacccttggtatagaattc cgtt accatgaaaggagtaccgcccgcctggttcttccagccatccatgtagcctttttcaggc gacc atttactataataatttatggaaatgacatcacaatattttcccgctgccttaattatat aact gttgtatttaggaaggctgtgcaggcgtgaacccagataaagcaattcaggatccttcga tgcc ttaaccgcattctttatggcagaataatatttttccgcacaaataccggcaaactcattg ttca gttcatccgttacatcagaaacatttgcactcttgtccttatccgtcataaacttggcgg ctgc aatataagcaggatcctgcttgtttgaaattttcaggaatctgtcgagcagcctgtttcc ccat gtagagaagtctatctcattatccgagaagaatcccaacacatccgggttgtttctgaac atgc cgaaagcatccgaattgagatactccttgcaccattcatcccatccatcataaaacacaa gacc tatcttaagattcacgttctgccccggatagctaattcccttgctattcttgaactctgc aagg aatgaaaaggaaggagcctgtgtcagaggacttgaagccgatttattataatcatttaca gcct tgtcgccttcttccttaccgaaagcgcagacactatgaaatcctatttcagagaattgtt tctg cgactttgccacccagtcatctactgaactgtaaagcttgccgaaagctgagctgttgcc atcc attctgaatgaggcgataccccttacataatatggataaccttcggggtcgactatccaa cttc ttccatttgagtttttctcaaccctgaaccgtccagtagccttggatttttgcccttttg cgta tgagccatatttattcacgctttgcaaatactcatcctgtgtttttgtctgctgttcata acca accaggtatggcaatatccttgtctttgcctctataaaagccttgtcaggtttttccgca tact cgacaattatcggttgatactgcttggtgctattaggataggtttcagcaggaccgggaa cagg cagttgcagttctacatcatcatcgtcattatcgcctgcattgtcgccgggagtattata gtcc tccacattccccggttgtgagtaaataacctcaggcggaatatatgagaactcctcctga gggt cttcacatgacaaagcgaagaacggaacactcaagcaaatggttttagtaataatagtag aata tttcattgttgcaaatatttagtaaattaatataaatcccatgtcctgattgtatccccc catc ggtggtctatcgggaactccatttctccccatgccttaacagaagtccaaggttggtcgg catc agtccagaatgggtcagaggcaggcaatcccaacggaaggaatgcaagtgtagtcatata cagg ctgccattgtttgtataatgattcgaaatgccagtctgatgtccgcagaatcctatggtg agga atccgccctcattgaagttattgcccgacttgaacatacgtttcatacacgctgtcagcg caca tctcacctgtgctttcgatactcccgccggcaactcattataccatgctataagagccag tggc tgcattgttgccatacggtaaggtatagagcgtccgaaaacagggaatgttccttcagga gata tgaaacgctccagaatcatggcgaacctctgtgccctcatcaatgccctgtcatagtact tgcg atagtcgaaacgtgtcctcacgcccgattccattattgcatgtatagattcgagatacat agga tggaacacataactgctataataatcgaatgcaaagtgctgtccgtctgcgtaccatccg tcgc ctacataccattcctccaccttgcggaaagtagaatttatacgatatgtatcctgtccgg catc aattttggcaaggaagctttcaatggtggccgagaacagcagccagttagtgtaaggagg gtca atgcgtcggagacctttgaactcttttatgtagcgttcctttgttgtctggtccagcggt ttcc acagctggtcgaacgcgcgcaggaaactttccgcaatataggcagcatcaaccagtgcct gacc atgaccgttccacaacagataatccggactattagggtccaccgcatttgcataactctt caat gcccattctttcagttgcttgcgctgctgtccttctgctgtatcatcgtcaggcaggctc aacc atggagctataccggccatgagacgtccgaaagtttccatatatgcaaccttcttgttac ggtt atcccagtttggacttacctcaagaatcatatttttctgcagttcccctttcgccatatt gctc aacacaggagcagccatcctgtaagccatatccgtccagtattttcttgtctcgttgttg tttg cctcgagataacgcacatactcgcaagcggcaagaaggaatgcgcctaccccaaagttgg cagt cgacttggcgtcaaccacctgtcccggaatagccttttcaccgattggctggacataacc cacc gaccagtctttctgcagtgcagtcttggtaagatatttccatgctttccccactacaggc ataa attcatccttgtcaagataaccgttgtttatcccccaaagcataccgtaagtgaagaaag cggt accgcttgtttccggtcccggagcatgttccggatccatcatacttcttgtccagtagcc ctcc ggctgctgcagacatgcaaccgcctttgccatacgcacaaacttatcctcgaaaaaagac agat gctcataaccctccggcaggtccttcagcacctttgccagagcggcaagcacccatccgt cgcc tcttgcccagaaatccttctttccgttcagactcttatgcttgggataaacatattttgc gtcg cgataatagagtccttcctcctcatcatacattattgagtccgacgtacaaagatattca taca gtttcttaagataccggtgattatgcgtaatcttatacatcttcgtcattaccggcatca ccat ataaagtccgtcgctccaccaccagtaatccttacgcggtgtgctcatctggtactccat gact tcgcgtgcacgcttgattttataattctccggcatgacgttatacaagtccgcataagtc tgga agcacacctgataatcgccgaacagcacataatcatcctttaccccgtatttatacttcc attc agatttgttgttgcttttcgcacccatccactggttatactcagcccatgcctccgaata cttt ctgtattcttctttcccagtaaggaaataggcttccatattaccggtgtgatatgccgca taat cccagaaagaccttgcttcgggggcatgatttttctgccaggcatcgttcactttttcaa tcat ctccctaacttgctgagcctcagtttttttttgcgaaggaaaatgaaggtaaaacagcta taag gatgtataacatccagtagtatctataacagttcatctttgtgatattgtttacattttc taaa acgaaatggggaagaatatatattcctccctcatttcacgaataattgtattattatatt tatt tgttaggagtccattctgctccgttgttgaaaccttctgttgtagagtcaaaacttgcat ctgc tcctgtacttggtctttctgtaatttcttcaatcttaaaagaagtgattttagcggttcc agta gcatcagtaccaccagggacattagtctgtacagttaaaataacgttctcaagaaccggc caca caagtgaaccatctgctcttgaagctggagtttcagcagaagtagaactactgattgtga atgt atttgtataggttccacttccggtatttcttccaatccagaatttatatttatcagatgc tccc aatctgaatgttgttgcacagtcgttagatgcgtatgtataagtaaatttgtaagtacaa ccat cacggaatgacattgatttagtaactgggaattgattatctgctggaacaatttccaatt ctcc acttgcattaattttttcggcaactccttctgcaagatattccttaactgcatctatgtt agcg aagttaaaatcaaaagcatctgcatgagtcaaagcaacattggcagattcaatcttgata ttag catcttcgttgttttcgtttttagcagtcaaagcactaacagcataatcagtgttataac ttac gctaatatttgcgtcattactataaatcttatcaccaagaataagagtcatagtagttcc attc acagaaccggaagcaacaggaattgtttttcctgctactgttatggtaaatgctttgtta acag catcagtgaatgttccagaaacttccttatcgagtgtaagttcaattcggtcattacctg ttgt ctgatcaggaacaatttctttagctgaagaaacggcaacagtagtttgtttttccaaatc caca ggaggttcaccgcctccttgatcatcattcaatactatcgttacaatctgtcctttagta acta taaggttttcaccactgaagttataagttttagtaccagaatttcttgtaagttctaaag taaa tccatcggtaaatgtcaccggagctacaaccattgagtattccttggcatttttattttg ttca ttaggaccaacaaatgttccctctttagcggttagagttataacattagaaccggattcc actg tcaggtttgctgaagcatcaatttttacgttccctgcaatctttacatcaccaccagcag taag tttaatacctgtaaggtcagtaagattatttttaaacttaaccaatccacaagtattctg gaaa gttaaagatttgttattatctgttgcagtagcataagatatatttgcatttgcatcgaat cccc aagccggagctgtctgttcagatggcagtgtagtagttacgacaccttcaagacacacag cttc ggcattataaggataaagagctgtatatgaattgttaggtgtagccttacctgtaaacgt tgta actgtgctaccacctgtagcggtagtaaacttgttattttcttggcctgaaaagatattg attg catctcctgttgtccaccacaccgttgttccattctgcaacgaactacggcttgaaggcg tacc ggcaacaaaagtcatatcctgaggaccactgactgcatttacattcgacagttcgtcttt tgta caagactggagcattgcaatactcatcaaagccgctccacaaaatagcatcgtatttttc atga cataaattatttgttaaacagtttcaataataaaaaatcacatcacttgttattcatatt ctta ttctttaggatcaggtttccattcagtaccgtcatcttcaaaatcatcatgaccgccatc taca attccgggaggtattgatattcggcataccgcactttttattccattacccgtatctaca gaag caccgatattagaatctctgcccccgtcgattgccacgaccgtacatctcattttatcgt ccga tggtgtaatcatcaacacatcagggaaagaagttccccaaactattgacttgtaaccggt ataa gggagattatccttggttatattaatacccaactccacagtgccactatatggtaattct atat aactgacaggtttgttgtcagtctgcccatccttgaacactacatattcaatttttatct cctc agctggtgttccatcacctccacctacgccatcatcatccttatcacacgagattgccgt aaac tgtataaaaagaagtatgaaaaggttgtatactgacagaatccgtggttttatatcaacc ataa taaaatgttatttaagcgccaaacaaaattttcaatattcaaaaggcataagaggaaacc ctga atatgccttattaccatgaaaacaaatcaatctacctttttcaatccggaatcagaaaaa tatg ttatttatttagaacatatttttccgatttgccagattacaatcacaataaataaatcaa caac taaatctaattacctaatcttataactaaaccctcaaacaatgttatttaaccttttcta tctt gacatcatcaagcaggaagcatccaccattacctgaacccggaacagctgtgaaacgata taca aaaccattttcctgcaatttgaatttaactgttgtaagattgtaattcttacggtctttc ttga cctcagcagtggcaatttcttccagtttctttgaatccggattatagtactcaatcctga agtt aggtttgtcaccccaactgtatttggtataagctgaaatctgatattctgctccagtttc atag ctgatgtttacagcctgccacataccaaccttcacctcaacagcatagttgcctgaatgt gcct ttttcgcatcaactattttgttatctttcttttcccagacattccatgatgtcaagtcac ctga ctcaaaatcaccgttcttaatttcctgagcgtatgcagaagtcatcatcattccgcaagc catc attgctaaaatttcttttttcattttttctaaggtttttaatttaagtattatgttgtat ctat taaaatcactcttctattggaaccaacttataagccctgacccagtcataataagtagta cttt tgtccttatccttcaagtcctcagctgtaggtacttgtttttcccaatcgtatgtttcag taac tatatgtatgaacataggtcggtcaaacggagtatctgtatattttgttgtaggcttgat agtg tacatatactttccgtcataatagaatttcacggtatttgcatccacccaccaacaaccg taag tatggaaatcttctgccgatgggtccgtcatatacgaaaccacatccgaacgtttcgccg tatt gtcagtacgtttgcctccttgttcctgataccaatagtgagtattactgttcatctgcat attc catgtcttgttccacggattatcagggttgacacttcttattatacccattgtttctata atat caagttcctgactgctccatgtctttatcttcttgccgcctttcattatttccttcatta ccgg gcggttggaaagccaaaaagtagacgacatggtagtgagcgaagccttcatccttgtttc ataa tacccataatgtgcctggttctttgcagaagcaaccgctccaccggcaagacgatattta tcgc ccggctttccatcaagtccttctgttggcgacaaaacggtattgattatacgaagacaac cttt cttgacactaacattctctgccttgaaagttgcaggcggccgaccgttagtccaataagg actt ttagcatgccatttagcggcattaagacgtttaccattgaattcatcagtataatcttcg ttaa ctacccatttataaccctcaggagcctcaggcaaattttttatatgctcttcagccaaag aata ttccttatcattttttaatgtataagatgacaggaataaagatgcagcagataaatacaa tact gtttttctcataaactttgtcgttttagattttttgttacacgacaaaagtatataagtt tcat gaaagcattaagggggatttacatcgtaaaaggtggggtaaaattctaccactccctgaa acac aattatttcactcatgaaaccatgtgtttttacgatatataaaacccgacagaagaataa tacc gtattaccggctaatttacataagaataacttttcaaaccgccatataccccactttacg tccg taccctcagtcctcgactccggcaatatgttttccatatcgagatctatggttttctgcc tcgg attcaaccactaactgtcgagcatgtggattgcgtatctgtcatagaatctctttccgaa ccat attatctcgtctgtgctaagtatgttgttcagacggataatctttccggtattttaccac ctac ttctcttgcaaatcctgatctgatataaccggatactctcaattcattgatttccgactt gtat acagtctgcgaagaggcattgaaactactgcacagactgaacagcagcaggggaataatt taac tgattttaatagtagacattctgtgttcataatatttcattttaatgattacgtttctga cttt cgtctgatgcaaaattatgaggtatcggacggggttgtatctttcagtaaaaatcagtaa agtc ttggcaaggggtaaaaaacttaacatcttgtatataaatatattacaaacaaggtgcaaa gatt ttcagtaaacgatggcgaatacagaacctatatatttacacgccataaaatgaagaaaaa gcag taggaaaaaaatgcgggcaagttccggataaaatgtgggcaagtttaaggtaaaacttgc ccgc attttagatagaatgcgatcgcatttaaaacaagtaaaaaacgaagaaaaaaaatatgtg ttct tcacagaacacatatttcaaaaataggtataaacacgctaaacaatgttaacaaaatcta ttta taaaaaaagctcacatcaataatatctgcaacatttttacaatactccataaatgaagag acct tgggatgatttatacacagagctatctgtgatgtaggcgaaaaacgtcctgtcccgtcaa gaaa cgctgtaagctcagatgggaggagtatactgccaatacctggatttacgtcagtcagaac gact gtatttacagcttccaccgctgacacatcaagataatcgagtgccggaagatctgcgaag tgca attttcctatcatattgccgcctttgctgccctgaagagagacactctccaatgaagaac aacc ggatatatggatttcactgtcgaatattgaagtttcggaaacatcatcattaagtataac agaa ggaacaactaccaattgaagcgaactgttattctccaccctaagtactttcaatgatgat gcgg aacttaaatccattcccaaaggtgtatcaatattagagattgaaaatactgaaactcccg aaga cggcttgacatacgacatggaataatgcttggacttcactcccgaaatgtctacttttcc tctg aaaccgggatttgacaatatatactccacaccctcaaggttagctgtctgcgacaggaaa atga ggtcgttcccttcggttatcctcttcgtgacatcaatctccaacgatgagacaaacaccg acgg gaagtttctgtaaagatatgaacggagcaaaggatccggtactcttcggtttactgtata ttca gtgtaatttccatcctcgtccgacatcacgacaagacatttgtccgtcatggctttatag aatg caggtatgacatctgtattccattttgcaaagtaaggaagtttcagatttgtaagacttt taca aagcaccgtagtgccatcggttgaaataagattgagatacgaagttatgccgtcattgcc gcgt aaagctaccgattttattccttcgggcaggtcagcaaagtcgaatatagaaaaactgtta cact caagattgacatctgcgagcgaaggaaaactcctcaaaccgctaatagatgtaagttcgc atct actcaagtccaaagaagtggtattgagaacttgattgtcacaaatcagctctccgttttc gctg aaattaaatcctttccgggtcaagacatcgcgtaactttgtatcaaaagtcacttcagac actt caaagtcggaaatttctgtttcatccttacacgagattattgtgaaacagagaactatca gtac ataaaagctaataaaattcctcataacaatcagttttgtggtaataagactatattatca atcc aagccgcgtcgttctgtctttcgcacacaatggcacacactacttttttcactgtagaat taaa atcgaaagatacggctttataattgccgggagaagaaaattcctctgtatataccgttcc tgta gacatatcctgtagcatgactttcaacttacatgctccttcggtctttacatcagcagag aagc gataagtcctgccactctccatgtcaaccctctgcatgagtcctgcatgaccagatatac aggc tacattattgcctgcattgtcagtctgtacgcaaaccgtaccatagttacccaatggctg ccat gctgaaagtccttcgctgaaggttccattctgcaaggtagagacagtatatttctcaacc tgca gtatcatggacgatacgtgacctcctccgtcggaaaaggtgatgtcgacattattatcgc catt cttcagcagctgtatgtcgaacggtacttctatcataccgaaaaatatattgcggttgct ctgg ccgtagcctttccagttgtcgggaacactcacagcggtaccattaatctttaccaccggt ttct tggaagcagagacaggacggcctatcgacatacgcaagcttgctctgcccgaaccggact cgat tcctgtgaaggggaacgaaagggatgatccggcggaaatcggtttcagatactcactgct gtaa tatttattgcggattatggagttcgtgaatgctgacgaagacacatctgctacaaggact atgg tctgatttgggacaattgagatgctttcaggcatggacgggacattctgttccgtatatt ctat acctgcgttataattgacatatagagaacgctttgtgacattcgatacatccttccagct attc ttattgttcagatatacagtctgcgggttatcatcaagattatcaagggcgatatagagt ctgc ctccatccttgaatgcctgtacctgaatatcaggattactgctggttatatcaacacgtt cgcc ttttacattcttccagagttcgaagaaatattttttgtcattaagcctccatgtggtatt cttc agattctgaggattgtcgggaataaacagtgccgcactatatgaagtataattgtttgca gcgg tgatatgccactcagccttatctgagacaaaaggtattgagataaacaaattgtcctgac gttc catcagattaaacagaaaatgattaaacgacgaaacactccgcacactgcttatgtcatc atag ctgtcgtcgggcttgctgttgtcaatacctccaaactcggaaatggcaagaggcttgaca tgtc cgaacttaatataggaatacgcctcaaccatatcaagaactgcttcggagttacttcctg aacg tttcgtatcggtgccggttacatttattccatcataaagatgtacagagaatccatccat atat gcacctgcccgatcgatgaacattttcatgcgggtgttccagtaattgaagttcccatcc tccc aggcggggtaggctgcggcatagcctatcaccttcatctttccgttaagacgcggattat tgtg tatatgtttacctattgaagcataaaaatcgaccatcagttcgcgcatagcctgtccctg aacg gtaaaaccggcatcatttgcatgaacgaacggttcattgaggggttcaaaaaactcaggt acca gctcgctgttggaataatactcagccgaccatgcacctgcagcctgaacgtctatgccgc cctg tatgtgctgtacatagggatgctctgtggcaatatatctttttacggaaatatttccgct gtat ggtttcatctgaggatatttgcctacctcatgcgtcttgttatacgcatacgagtatggt cccc agaactttcttccaagaccgacctgatagtcggcaagaaacttgcctacatccttatcat catc ggaggtggaatgaatattgaaatatttagaacggtcgagttctgaaacaccgctcaaaaa gcga cgggtattatagtcgacaaccacctcgttcctttcctgacaataaataccgggaggaaca ccta gggtaaatgccgataacagaaaaatatatttatagctcataatttctttccttttagaca caga aacttgtcagtcctgatgtggatacattattttctcactttcttatcgtagcgttcagtc tgaa gaatcatagtagccacacggcctccattatccgggaatgttactgacaccgaattttttc cttt tctgattaaccggtagtcgaaaggtatttctatcataccgaagaaatcgtctctgccggt ctgg tcatatcctctccaattgtcgggcatgtcgactttcttgccattaaccattatttcaggt ttct tcgacatctcgtgcttcctgcctattgacatacgcagaacagctcttcctgtacccggtt tcag accatcgaaatcaaacacaattggttttccggcttccaccggctgaagataagtgttgct ataa tatttagtacgaactattctgtttgaatactttttacggatgatgtcggcacacaatatt attg tctcatcttttataatgtcaatactttgaggcatcgagttcagcgtcttttcatcataaa ctat acctttatcgaaaatcatcttcaaagagcgcacagaaacattatctacacccttccaatt cagt acgtttttcaagtttaccttatgtgtatagtcatcaagattgtcgacagctatgtaaagc ctgt catcgtccttaaaagctgccacctgtatgtccggattgtcggaaacaatatctacacgtt cgcc tttcacatccttccataacttgaagaaatatttcttgtcgttcagtttccatgcggtatt cttc aagtcgtgaggattgttggcaacaaataaagcagctccgtatggttcgaaattatattgt ttcg ttatatgccattcggccttgtcagaaacaaagggtattgagatgagcatcttgtcttcgc gttc aagaagattgaacagtatatgattgaacgaagcgacagttcgtacagaggctatcggatt atat cctttggaagtgttgtctattcctccatattcggttacggcaagaggaagaactttcccc aagc ggatgaacgagtagttttccataaggtcgagaatagcttcggaattacttcccgaacggc ggga actcttgcctactatgtttattccatcgtaaagatgtaccgacaagccatccatgtactc cccg gcacggtcaatgaacatcttcatagtattattccaatggtcgaaatcgcgcaactccata gccg gatatgccgcggcatatccaatgattttcatttttttcagacttggctcagcgtgaatat gctt tcctgtctgtgcataaaaatctgccatgagcatcctcatttcctgaccatgcatattgaa acat ttgtcgcgtgcatggacaaagggttcgttaatgggttcgaaaaattcaggaactgcccct ttca catgcttggaatagtattcggcagcccatgcacccgccttcactgggtctatgccccatt gtat ggtacgcgcgttggcatgttccgtagcgacatatcgttttgtttccttcaaatcagtgta gttc aaaggcttttctgaaaaaggatattcgccaaccttttttgtcttgccatatgaataagag aacg gtccccagaaagagcggccgattcctacaccgtaatctgcaagaaatttcctgacatctg gatc agaatctttagatgtgtgtatattgaaatatttacctctgtcaagtgccgatacatcatt cagg tatctctgagtggcataatccactgtgacagtagtgttataagtcttattctcggaagat gata aaggaaaaaccgagaaagacaaacacacagacaaagctgtaagaattatgttattcattg tatt atcaaaatttaaaaggcagagaacactccgatagttcaattaaagtattccctgccatta agat tatcacttctgtttaaacactaatatcagaaatcggccggtttgagtacatcgttcagca ccac ttcatattcaacttctgttccgtcgttttcagtaacagtaagatggccgtaaccgccact tgag ttattttctttcttaccttcaaacatgaacattctcttcttcgtcacttcctgttcttct ttat cgcctgtttcaggattgataacttcttccttttcagtatagacttcattgaaagagaatg agag atgtttttctgtatccgaattgattttcagccactcgggcaattccgaaggagcctcaga cgac tcggcaaagaactcgatcttattcattctcaaagtctgatagtcattcttccaggcaatg aggt cgaacaattcgcgataaacagaaaacttggaaacctcgcctgtctttcctgtttccacat tctt gagataggtaagttcatacacgggagtagaatcaagttcgacctcagcccatttgtcatt atca catgctccgaacaaaaccaaagcacataagaatgtaattgtcttataaattttatctatt agct tcattgttactataatttattatggtcttacttcaatatatccgaaaaatatatcgtcaa aata aatattatccttaaaggcattaaagcgcatactgagcaatatattgtccatttcagcctt tgaa gtcacagtggttgtggccgacatccatttgctgtcggagccattcacaatgccgcaccat ggtc tatcgctctgccatgtcatatcttcagctccttctttacctgccggaacgaaatacggac tcat acccttaccctgtttataccccggtgtataatatttgtagctgaaagtatatgtaccttt acca ccagtaaatgtcttggagagtaatgccctgcatcggtcaaatgcttcgacaaacatacat tttg cactgttgtttattccatccttcagaggattgtccacaacctgtgaaggaactacaggat gtgt tttggtatcggcatcaataactttccagtcggcatatgtgtcagaattttcaaaatcttc atcc aggaacgcaccaaaagtagtcgctacgtttggagctgtagcctttatctcaaggttctga tatc caaccaacgcttcagttaaagttcctgtaagggtcagttcatctgtgttatagattttct caac caaagtaagaatcagttcatatctgctttgcttgtttacttctgctgctgtgatgtttac gcta cccctgacagctgacggtctgttatacgagttggagtaagtaagctttagagatgatgga ttta tctctttatatccaaactcagaattatccaaatctatagcaatgtgtgtttggtcaatct gacg gatgttataagtaataggatcatcactaggtactactgtaatagccaaaggcacaacaag agtt tttggcgaagcttttggagtgtacttacctttaccctcactggcagaagttctttctatt gtca tggaaagaagcaatggcttatcgctgaatttctttgcagtgaactggtatggagtgtcaa aact ggttaattcgtcatttacgccagtatccgcacatttgaaagtccatttgttaggcaatcc gtat gaatcgtccttaatatagacagacttaccatattcaagttcgtatttttcgtattcggga gctt cctcagttccaccgactattccggtctttatttcctgtgtacactccggatcactgtata cctt tacggccggtacgaggttaggatcatacacgcggatatggaaagttgtatccatcacata taca tcaccctcctgcttagcataacaatattttttgatatatcctccggtattgtcgtcatac accg aatatggatatacaacctgtctgcggaaagtattgcacaaacgtaccgtatggtcaccgg gttt agtgaaatacacatgtatggttttcaaatcgttggtatgagggatggattcatcaatcag gttt gtatagtctgtctgtccccactccatcttaccattaaggaactttgtaccatcatccgac acaa cccactgatgcgacaacatgccttgggataagtccattatacttatatagttattaagat tcag ctgaataggtgaaacgttttcctgatctgtactcacatgccaggtacattcagccacgtt attc aacggttcaaactcatcatccttacaagatgtcagaaccgagattaatgaaagagcaata tata aaaatctatttttcatcgtatttatttattaatatcaggatttgatgtaatttctatatt tgga ataggccagtatgccacttgcggaccgtagttcaatgatgcttggaaataatccacaaaa gcgt ttcctctcttttctggcggcagctcataaaatctgtactgctttccaaagttgaatgctg atac caaagcattagggtcatcaggattaggcttaagatatttggtctgaatcatacagtactt atat tcgtcggatgccaactgatcaaacctttccttagttatattccagcgtctcaaatcaatg acac gtatggcatgtccttccatacacagttcaagaggacgttccacatacatcagatgattca ttac atcacttgcagcatattccttctcatcgtatgtatatctcttgaattctccctgttccga tttt ccgataagcacaactccagcacggtgacgtaccttgttgatggcattgatagctgactga acat ttccatcgcttgcaccgcctttaatcagacattctgcatacatcagatatatatctgcca aacg gataagacgatagtttattcctgaggccatagcaggcttaaattcagtttcactcttacg tgta tcccaatttgataattttctgaaatacgctgaagagccacggttgaattttgatacctgt tgtg ggagagactgataatatatcagactttcatcgccgtttattgcaagagaggcagatgcac gcat ggaatagcttctgaggcgatatgcctgaccgtcttcccatttaaattccggaactatgtc atcg tagccggtaatcttattgtataaaactttattatctccgacagttgagacgagtcgttcg cgta ctccaacatattttcctgctgttgcatcccacgtataaacgtacgttctgttatatacga cacc ctgacggtccacctgcgagctgaaagttgttcccaactggtcgtatataatatccctatg ttca ggatcaccataattgtcggactgcatttttatccagttacgttcatcaagtctgtccacc ggct ctgtttcgaatgcttcaacaagccaaaaagcaggaacagtgttaagccaggcatcgccca agcc atttacattcattccccatatattatataaggtagactccgaccatgtaccgaattctgt atta tactgtgtagaataggaaacctcgagaatagattccgaattgaattcattggcagcagta aaat tatcgactatgtcatcaaccaaagcaaaacctccattatcaataatatccttaaaatatt cggc agctttattatactctttatcataaaggtagcttttgcctaatattgcctttacagccca agag gtgatacgtcccaaatcggttttctcccatttgtcattcaagccaaggtcaagagctttc tgta aatcttctctgtaatatttcttgatttcatcacttggtgtaacctttttatagtaatctt cttc tacctctgcaatttcattaatataaggaacattaccattattgaatgaattattgagata aaaa taaaacaagccacgcaaagaatatgcctgtgcctcaatctgagcaagcttggttatttga ggtt catctgtaacatttggacggattttctctatactggccagaacctgattcgcacggaaca cacc agtatacagtgcagaccatttaccacggactgttccgtatgaatcattaaaggtttgctt atag gcttcgttatcaaactgctttctgtccttattaccttcaactgctatatcacttctacgg ttct catcgagcggatgataaatattggtatttttcaaagcattatatacagcagccagtcctt tctc gcagtcgcctattgttttataaaaattctgtgttgtcagctgatgtatgttttcctgcgt aagg aaatcgtcgcatgaaaccaatgtcatgcccgacatcaacagactgaatactattgtttta tatc tgaagttcatatatttatattattaaaagttagaaattaatctggaatccgccacgcatc tgga tacttataggatatgttccatagtccaaaccacgacgtgacaatccattactaccgacct cagg gtcgtatccgtcgtattttgtcagtgtaagaagattatcggctgcaacgtataaacggaa cttg cccaatccaagctttgatacccaactcttggggaatgaatatcctaacataatattttta agtc tgacaaatgaaccgtcctcaatccacatatcagtatgagcacgatagttgttatgcccct ctgt acgataagaaggaatggtagaggtatagttggtaggggtccacatgtatatcagttcctt attg gttcttctttgatatgtatatatcttcgtaccgtttattatttcatttccaactgaagca tacc agttcatagagaaatcgaagcctctatagtcggccgagaagttcaaaccaagttcataat ccgg cataccactaccggcataaacacggtcgtcatcattaagaacaccatcattattggtatc gata tacataaggtcacccatacgggcacttgactgtaatttctgatattctgcaagcttctgt tcag tattgattacccctgcggttggcataacaaagaaagcaccggcttcatatcctttcttga ttgc agttacataatcacttcctgatgaaacaggtttaccgtcggggaagaaatataactcatt tttt cctgccatagacacaatctcattcacgtttttggtaaatgtaccagtcaagctgtaatta acac cacgtattttgttgcggtgagtaagtgaaaactcaacaccacggttttccatatctccgg catt caatgtaacagttgaactctggccccctccatttgacggtggcacgaccatcgggaaaag cata ttcttcttgttactcttgtacaaatcaagacctaagataagcttgttattatataaagcc atgt cgataccggcattaagctgctgggttgtttcccatttcacattcggattggcaaatccca attg ggtaaaaccatttgcaagaatttcggaagttccggtaccaaaagtatagtcgtagttttt gtat atagctggtgcgtatgaataatcagggaagttctgattaccggtagtaccatagctgaat ctta attttaacgaatttactagccacctgaatctgtcgaagaatgattcctcagaaatattcc atcc tacagacaatgacgggaacaatccccaacgattttcttcggagaacttagatgaaccgtc gcgc ctgatactggcacttgccatgtatttgtctgcatagctatattgtagacgacccaacata ccaa ccattgtactgatacggtcctgtccccactggccactgcctgtacccacagtcatatcgg atgt tcccgcatttaggttcggaatctcgttagtaaccaaatccattatactggcatagaacat ctcg tatgtatatttctccatactgaaaactccggtaaatttaatatcatgcttttttatcttc ttat tataatttaccattgtttcccaagtgagactggtattctttgaatgagtatcttttaatt gcga acggtaattagagctggttaccttttcgcctttctgattatatacctcaaactcaggtcg aatt gagacagctttctgattgttatatccaaagcccaaacgtgtggaaacattcagtccggga atta cattataagcaagataaaaattaccgttaaatgattctgtgtccttatgattttcctctt tcaa tcttcccaatgtataacttacgccctgtaaatctgcaggatcgccagctgcatttactat actt gcctgtggataaatctgagaacgagtaggcgagtagtcataacattcgttcaataacccc caag ccggagataactggttttctatcttcatagcgatgttagtgttgatagtccattttccgc gctg aaaatgtgtattcgaacgaatattatatcttttgtaatcggaatttatcaacacaccttt ctgg tcgaaatagttcgcggtaaggttatatgtcaaatctttcttgccgccattcgcagtaaca gaat aattctgtattggtgcgttattattgactacatattcatataaactagagttgttgaaga aatt cacaggatatgttttcagattagaccaggccaggtcgtctgtattctggtttccttccat catt ctgttagacatcacttttacaaatatactctcgttggcatcaagcaaatgaatattcgaa gtaa tgtgctgtacaccataatatccgtcgacagctatcttcatttctccttccttacccttct ttgt ggtaataaggataacaccggaagcaccgcgagtaccataaatggcagccgaagcagcatc ctta agaatatctatacttgctatttcgctactactcaatcccgggtcgccctcgaacgggaca ccat cgacaacatataaaggagaactgtcgcctgagatagaacttaaaccacgaatctggatgt tgga tttggctccaggctcaccagaacttgcctgaacgttaactccggcaaccataccctgaag agct gtacccaagtcggaagtactgatcttagtaatctcatctgagtttacacgtgccactgca cctg tcacctcttttttacgcattgagccataacctacaacaaccacttcatccaacacttttg tgtc ttcctgaagcttgatattataaatctgaccattcttgattgcagcttttacagttttata ccca acaaaactgaacactaagttacctttagtcggtaccccttgaagaacgaaattaccatcc atat cagtaatagttccaagagaagtaccttcaacttgaacagctgcgcctataacttcaaggt tatt ggcagcatcaatcacctttcctttaactgttatcttctgtgaatacatagacaatgtata gaag ataagcatcacgaacaacatgtacctgccatggtaccattttttctgatttctcatttgt aaaa attttaatttagcaataggttatgaaattccttttataactgacgctaaattatttattt ataa tggtacaaaaggggagaattatatatttaaaaagggggtaaaattttacccccacttata ttaa gaatccaaatcggtctgtatactctgttctttgtactgttgcggcaatacaccgaattct ttct tgaaacattctctgaaatacttcaaatcattgaaccctacatcgtatgtcacctctgata caga ataccgtcctgtcttcaacagttctgccgctctcttcattcttattgaacgtacaaaagc attg gctgttactcccataagtgctttcagcttcttgttcagaaccaaggccgtcacgccaaga cctt tacatatatcctctatctggaacgaagagtctgtaatgttgtcctctattatctttacaa gttt ctcaaggaacttatcgtcggtagatgtagtgcttacctcggaaatctttattgccggaac tttc ttgtgttgaagaatccgcttcctgttggttataatggaattaagcagctctttcattatc ttgt tgtcgaaaggtttagggcaataagcatctgcatggaatttatatccgatgaaataatcct gcaa tgtagtcttggctgaaagcaatactacaggaatatgagatgtccttacatcctgcttgat tctc tcacacagttccagaccattcatgcccggcatcattatatcggataaaacaagatccggt tgca aatctggaatcatgttccatgccatctccccatcatgggctatcattatcttatacttat ccga caacagtaatgacaacatattacatatatccttattgtcatcaacaatcaatatagccgg agat tctccgtccacttctatgtctatcatctcttcatgctcgcacgattcacttcttaacaca tcag caaacttttcatcctccccactgttggcagagatattctccgtaaccatgtccccctcag ttat cataggaattacaacatggaaaacagtgcctttaccttcctctgatacaaacgtaatatt tcca ttatgtatctctacaagccgcttggtcagaaacagacctataccggtacctccttcagca gagt ttttattctgactgtagaaacgctcgaagaggtgtgttttcaggttgtcggatattccgt ttcc cgagtctgccacagagatgtttattttgttatcctgttcattgacagtaaacgatacaaa tcct ccggcaggagtatgcttaatggcattcgatacgagattatagattatctgttccataaga tgag ggtcgaacagaaagcttatatcactgcgtgagacagaatattccagccctacacctttct gttt tgcccaatacgtgaactgctgaaatacttcttttgagaaagacgagaagttgccatattt gaga ttcagactaagcattcctttctcgctctttgagaagttcatcagctggttgacaagactt aaca ggaacttactgttatgctccattgtctgcagcatgccggcaagatacttgtcggacgaat actt gcccgattcaataatcatactaagtggagaatgaataagtgtgagtggtgtcctcaattc atgc gatatgttggtaaaaaatgtagtctccttttcaagaagttcttcagtcttgcgtttttcc atgt ttgctatatatagagcatttctgcgctgcacccgtgaggtataatacaccttgaaccggt ataa agacaagacaagcaatataaaatagagtgtataggcataccatgtacgccagaaaggagg gtta ataatgacaggtatggaaagttcattcaaactgtagactccatcgctattcctgaccctc agtc tgaacatatattcgcctgaaggaagctttgtgtagaaagcctcacgatgaaaagcggagg tgga aatccatgaatcatctacgccttcgagcatatattcgtaaccaaccttataaggacttct gtaa tccagggagctgaactggaatgagaaagtgtttaaattataaggcaattcaatgtgctct gtaa aacttacacttttgtcgaaataagctgaatatgtggaatctgcctcaacgctgtgattga agat tttaaaatcaacgagtgtaggactaccgttgaaatctatcacatcaaagtcattaggtct aaag acgttaattccgtttacgccaccgaatatcattgttccatccgtcattactccagcagaa agtt ccataaattcataatcctgaagaccatcgaaaatatcataagatcttattctctgtgtgt tgat attcaacgaattaattcctttattggtagaaatccataatgttccatccgtgccattaac aatt gattttattgtattgctgctcaacccgtctgcagagctaaaattttcaacgcaggcatta tggt tttcatccaaatccacgattttccttaacccacgtccaagtgttccataccagatattat gatt caagtcttcacatacaggcactatatagtcgagttcatcaagtcccttgactgagttcaa aaca ggattatctatatacaaatctgcagattccaatactttaagaccgaagctggaagctacc cata tattacccttatgatctttaatgatgtttcttactatcttaagttctttattgtcagatg tttt gatttccttcatcacacctgtggacaaatcatatctgaaaagacctttattatatgtgcc aatc cacaaatattttccatcggcaagcattgcgcgcacatttctcaaacctgagatcttttta taat cattatcagaagtgaaactgtaaataccatcgtacatcagagacacatacatgcagtcgg tgta gtttgagtatgctgttgagtatactatcctgtttgccgtgaaaggaataagtctggcatt accg gtaatggaattaaaatgatatagccctgagccttctgtgcctaaatatatatcagatttg gcaa atgtataaacggacgatatatgatcatttcctattcctctgaataaatctataggtttat tatt ttcgcgtatactcataaagccactcttgaaaaatcctatccaaagaatatcgtttttatc aaga actacagtttgcggatagctgtaagaatatgtagcaataacctgtggttttgactcgatg gcat gcaatacatcaaaagtcaacacattcacagtgcttgtagtggcataaaataatcttttgt tttt atataccatttttcgtatatcacagttttccaacagggtacttaccttgcaggtatgctt gtcg tataaacataattgatgattttccagatttgagtacaatatttgagaagatgagatgact atgg ctgaagctatagggcatcccaatagtttgttaagcagtaattcatctccatcgacgttac attc gtacaggccgtcttcggaggagagcattatcgtattatctatttctatgatgtcggaaat gtat ggtaattttaatgttgatcttaagacagtatttattttgccattttgaaaatcataattt acaa ggtatatactttcatcagaggaatgaaaccagactctgtctttagagtcgacaagaatct tatc gcaagtgaaatttttatcaataccgctgtgaccaagatttaatgaaacgaattcgttctt taca gaattgaacaggaacactcctctatcggctgtacctatccacagatttccatgtgaatct tcgt caatacatactatcagattactgttaagaccgtttgactgatatccgtaaaccttaaatt cata tccgtcaaacctgttcagtccgtcgttcgtggccaaccatataaagccttttgagtcttg ataa atacattgcacatcattttgggaaagtccatcaagagtagtgtactttcttgtgacaaac tcat tggatgcaaaggatttgcaaactataatcagaactgatattaaacttaagattaatctaa acat ataactattattctttatatttcatcaagattacaaagttattgattttatctaaaacat caag tatttacagtagttaatagataattatagatattttccactttagaatgcgtatcaaaat caat caagaaaaaaataaatctttaacttcatttcatagtataaaacaaaaaaagcatcgtacc atta cactcaataatagatacgatgcccgaaagaaattacagtaacagactgtattgggattgt tctt aaaaagacttatctgtatgactttatatatatgtcgagtatttcggtatccgacagttca tgag ggtccagactgaacaatgcacccatggcagttcgcgcattatcaatcatcttagggaaat cttc ctttactattccccagtcgctaagcttcaaatcgcggacattgcattccttctgcattct cacc aaagcatctataaaatgttcgggattaaggttcttgcatccggtcataacatctgccatg cgca tatatctctttgtcctgtcataaataaaagtagagaaataggcctcgcttatagctatca ggcc aacaccatgaggaagagcgggatagtatgcgctgagagcgtgctcgagagaatgttcgga agta caactggatgtggattcaaccattcccgccagcgtacttgcccaagccacctttgccctc gctt tcaggttatttccatccttcaccgcaacaggtaaatatttatacagcagtctgatggcct caag agcgaaaatatcacttattggggttgcacaattggcaatatagccttcggctgcatgaaa gaat gcgtcgaatccctgataggcagtcagatgtggcggaactgaaaccatcagttccgggtcg atta tcgacagacatgggaaagttaaagtggagccgatacctatcttttcgtttgtttccagat tggt tatgacagtccatgggtcagcctcggttccggttccggctgttgtaggaatggctatgat gggc aatgctttgctgtaaggaagccccttgccggtacctccttcaacatattcccaataatcg ccat cattacatgccatgattgcaatggatttggccgtatctatcgaacttccgcctcccaaac ctat aatcatatcgcaattttcctcacgacagattgccgtaccttccattacatggtcttttat tggg ttaggcaatatcttgtcgtacaccacggcatcaacattattttctttcagcagaccaatc acct tatccagataaccatatttacgcattgatgttccggatgaaatgactatcaaagcctttt tgcc gggcaatgtctctgttgaaagacgtttaagttcgccacatccgaagagaatcttcgtcgg aata ttataaccaaaaacaaaattattgtccataaatattatcagtcagtcaacttactatctt aaag cctcatcaatcactttcttgagttcaggataagcctcatctgtatcgcccacctgttttc tcaa ctcacgcagtttctttttcatgtccttaagaactttggcgtatttaggattatcagccag gttt accatttcgtaagggtcgttcttcacatcgtagagttcgaaagaaaccggagtaggaaca atct tgtggctgttcttcaaccatgacattgatttctgtccgtaacgtttgtcgtcgtaatgac ggcc atagaaaagtatcagcttatagttttccgtgcggatacctatgtgtgccggaacgtcgtg atga atcatgtgcatccagtatctgtagtaaacagcatccttccagttttctggctttttgcct tcga acacagaggcaaagctctttccatccatgtatgaaggttctttgccaccgaccatctcta taag agttggagcaaaatcaatgttgttaatcatcaggtccgacttggctcccttgtaaggaca tctc gggtcgcggactatgaaaggcattctttgagattcttcatacatccatctcttatcctgc agat cgtgttcgccaagcatcataccctggtcgcctgtatatacgataatggtattttcccaga gtcc ttccttcttgagatagtcgaaaagacgtttcaggttgtcatccacaccctttacgcaacg caga tacgatttcaggtaatgctggtaggcaaggtatgtattctccatttcatcacctgtattg cact tatattccattacataattgcggatttcatgacggcttgagacagaagttccgatgaagt gacg aagtgaatcgttcttgcctcttgtgccttcggagccccatttgtctgtatcgaacaatga caat ggaacaggcacttccacatcgtcaagataatattcatagcgcggtgcgtactcgaacata tcgt gcggtgccttgtaatgatgcatcatgaagaaaggtttggacttgtcgcgtctgttcttca acca gtcaatagcaaggttggtcacgatatccgaggagtaacccattttctttatctggttatt aggc catttcttgtcagttacgtcacttgtaaggaaaatagggtcgaagtattcgccctgtccg ccat gaccgttgaatacagaataatagtcgaagtgcgacggttcgcatcccaaatgccatttac cgat catggcagtctgatatcccatattatggaactcatcaaccagatattcctggtccggctg aagc acttcatccaaagtgagcaccttgttacgatgggaatactgtccggtcatgatacatgca cggc ttggggtactgatggagtttgtacagaaacagttctcgaagagcataccgtcccttgcca gttc atcaattgtaggagtagggttcagtactgcaagacgacttccgtatgcgccgatagcctg cgaa gtatggtcgtccgacatgatgtagatgacattcatctgtttctgctgtgctgcgacacca acac atacagacaggaatggcataacagccattcccttcattatattattttttaaattcgttt tcat aagtcagattatcattgaaatagaacttgcaagacatatcatcgaatgattttacgtcct tatt ctgcattttaacccattgttctgatttagccttgacagcgacctgagttgaaacctcatt accg tcgactacacttttaagagtgacatttgcatcctctgcattatggtttgccacacgtaca gtga taaggcatccgttatcaaccttatcgtatagcggtttggaaaccaccgcccctttaagct taat cttgaacacatgtgcatattcagtaggtttgttcttagggaagtttactacaagaccctc gtca gtcatcttatagtcaatcttctctgagcttccaagcatttcaaccgactcaatttccacg ttct ggcaatacttaggagcaaatgacttgatagtaacactaccatctgtccaagccagagaca cggc atagaggttattgtcgcgtgtagtaaagcgaatgtcgtccgctgtatattcagtttttgt attg tctgtcatataacctgcggtgcctgcgttatgtccttcgaaagcaatcacccatggtcgt gagc cataaatagcctcaccgttagtcttcaaccatttacctatctcggcaagtacgttcttct gttc gtctgtaatagtaccgtcggccttaggacctatattcagcaataagttaccgttcttgct gaca atatcaacaaagtcgtcgatgatatggtcaggactcttgttttcctcgcccacacaatag ctcc acgatttcttgcctacagaagtatcagtctgccatggatattcacggattctgtcgctct tacc tctttctatatcgaacacctggatattgtcgccatatccgaatttagtgttaaccacaac ttct ttattccaatcaagagccgaattgtaataataagccatgaatttatagaaagtaggctgg aacg gatattttcccacagtccagtcgaaccatatcaattcaggctgatatttgtcgataagct cgta tgtatgcataaggaactgacggcgtgaacgttcgttcgagccttcatacttaccacaata aggt gtcataccctgaccttcgggctcatgcagtctttcgccatacagagtgattgtagtgtcc tgaa catcagaaggagtttccattccatattcatagaaccatgcattctcgcatctgtgagaag aaag tccgaaacgcagaccggctttcttggtagcttccttcaattcgccgattatatccctttt cggt cccatatccacagcattccacttattgaaagtactgctgtacatggcaaatccgtcgtga tgct cggccaccggaacaatgtattgtgctccagatgattttaccactgccagccactcgtcgg catt gaaattttcggctttgaacatagggatgaaatccttatatccgaatttggtcaaaggacc gtaa gtctgtacgtgatacttattaataggatgaccttccttgtacatccagcgggaataccat tcac tgccgtatgcaggaacggaataaactccccagtggataaagataccgaacttggcatcct taaa ccattcaggaatagtgtaattttgagcaatcgatgccgaatcggccttgaacacatcagt acct tttaaagatacagtagaatctacattaggagcgtatgtagaattgcacgacgccaacagg ctta atgccgcaactcctaaaaccgttttcatggatttcttattcataataatcttattacatt aaat aatgacattaattttttctgtaagcaaagatacacttgagttccatttacaataaataat ttaa ttactatagtaaggggtaaaatatttaccacctattattgaacaaatttaccccctctca tata tgataataaactgccaatatcgaattacaagtaaatatatatttcaacaaaaaaggttta gcct attattacacaacaatttcaccctaagaataaaatatatatagagtaaatttgccaatat aaca aactgtaaaaacaaatttatgaaaaactatttgatttacttactcgcagcagtatcgtgt acaa ctgtagcagacctaaatgctcaagtcagtacaaaaacaggtaatgaaaccacagaactta caat tccgaaaaagttctacaaggacagcattgatttcagcaatgctccgaaaagacttaacaa caag taccctctttccgaccagaagaacgaaggcggatgggttctaaacaaaaaggcctctgac gagt tcaaaggaaagaagctgaatgaggaaagatggttcccgaacaaccctaaatggaaaggaa gaca acctactttctttgcaaaggagaatactacatttgaagacggctgttgcgtgatgagaac ttac aagccagcaggatcactgcccgaaggatatactcacactgccggtttcctggtaagcaaa gaac ttttcctttacggatatttcgaagcaagactgagaccaaacgactcgccatgggttttcg gttt ctggatgtcgaacaatgaaagaaactggtggactgaaatagacatttgcgagaactgccc cggc aatcctgccaacagacatgacctgaactcgaacgtgcatgtatttaaagctccagcagat aagg gtgatataaagaaacatatcaacttccctgccaaatactatataccattcgaattgcaga aaga ctttcacgtatggggacttgactggagcaaggaatatatccgactatatatagacggagt actg tacagagaaatagagaacaagtactggcaccagccattacgcatcaatcttaacaacgaa tcga acaaatggttcggagccttgccggacgacaacaatatggattctgaatatctgatagatt atgt aagggtgtggtacaagaaataagaaataacataatctgaaattataaaaggcagtcttca ttat cagtatgctgatgataaagtctgcctttttaacaagaagataaagattttaatctgccct atca ctcatttacttcatccggatactctgtaagcgagtttcccgaattgcttatttcaataga gccg ataggaagataattgaacttcttgctccatgcagagataccataatctcttctaagaata ggca tcatgacctcctcggcacgtcctgagcggacgaggtcaaaccatctgtcaccctcgcatg ccag ttcacaacgacgctcataccatagaacatcaattacgcttttaaatctgtcaggatacat ctgc attagcttgtcaacatcaatataacttccgtcgtctgcatgaacatgcttctttctgagt tcat ttatgtaatacttcgcttttgcttcatcaggattagtacctctgagatatgcttcggcaa gcat cagatacacttcaccatatctgatgacccttacgtttccaggcttgtttagattggggtt tcct atcatatcgtaatttttgaaaggaggatatttcttctgggcatatccctggaaatcaggc ccgt aagagcctgtctcccaaacaactttttttgattcatcctgaatattggcattaggtttgg ttac aagttcatcgtaagtaaatatcgccgcatcacgacgcacatggtcatccggaaggaaata atca tacaattccttagtaggcagacaaaagccatatccattatcataatcaggactatttttc aact gtctcggtccgcagaaagtcacccacatagcaccttcgcctgcatcaatattaccccagt ttgt attaccagatttggtagaggtctgtatttcaaatatagattcctcgttattctcctgatg agcc gcaaacaatttagaataatcatccgtcagagtataattaccacttgaaattacatcctcc aata aaggtttcgctttgtcaaaaatcttagcatcatcgttgctccagtcagcccaataaagat agac cttggccaacagggcttgagccgcagtcttggtaatacgtcctttcattgtgtccgggaa atta tcctttagagaagggatagcttcaagaagatctttctctattgctttatttacattttcg cgag tatctctcgtaaacttgaatccttcaggataaagagtctcaagactgataaagcatggac cata atatctcaacaattcaaaatgataccaagcacgtaagaacttagcttcagctttataaac ttta gcttccggactgtcatactctgaatttattacaagattacatctatatataccacggtaa cgag ttttccacaaattatcggaaatagaattgacactcgtatttgaataatcctctatagcct gcat gtaaggctgatcctgatcagagccaccaccagtacgagcattatccgaacggatttcacc cata ggtacaatggaagcaagtgcattacccgaagcaccacctatgtgagctaacggatcataa caag cagtaagcgctttgaacatctgttcatcggtcctataaaaagaactttctgtttcggaca ttat aggagctgtatccaggaaactgtcgctgcaagatgatgatgcaatagcagcaaacatgag gaca agaatattattatgtattttcgacttcataattttcaattttagaaattaagacttaaac caaa tctgaatgtacgggcctgagggtaagtaccatagtcaatacctgtgctaagaatattgcc acct gccatatttcctacttcaggatccataaacggatagctggtgaaagtggcaagattatca attg ctgcataaattcttgctttattcagcatcaacttgtttattaatttagttgggaatgaat agcc tacctcaagtgaagaaatctttaaatgcgaaccatcataaagataaaaatcggatggttt gcca aagtttccattaggatctttggatgaaagacgaggcactccattatcatcaccttctttc cgcc atctgtcaagatagaatgatggaaggttgctgcgtccgtatgcttcctgtcggtaaatat caga gaagactttatatccagcttttcctgttaagaagattgtcatatcaatacctctccagtc ggca cctaaattcaaaccgaatgtccattttggccaaggattgccacaatcggttctatcttca tctg taatctgcccatcgttatttgtatcttgccatataaagtcacccggaacggcatcaggtt gtat cactttaccgtcttttgatttatagttctgtatctgctcttcattttggaatattcctaa gttc ttataaaggcggaaataacccatagcatgaccttcctccatacgcgttacattaacagat gttc tccagctaccaccatcagtatatccatttacatttcctatctttacaacctcatttttaa gata tgaggcatttgcggaaatagagaagttgatttcgttccaatttttattaaatgtcatctg catt tccacaccctggtttgttatattaccaaggtttctaaaagctgcattattacctctaatg gctt caactgttggctggaacaacaaatccttagtactttttttaaaccagtcgaaacttgctc taat cataccattatagaatgtcatatcggcaccaacattaaattgttcagaagtttcccattt cacg tctggattaacaaggttattaggagcagatcccacagtgatggcattaccaaacgtgtaa ttat aattattgccaataatagaagtataggagaatggagaaattcgctcatttccgttctgtc ccca agagaatctaagtttgaagacatcaaagttcttaattttccagaatttctcatttgaaac attc caacctaatgaaacgcccgggaaagtagcatatctgttattgggaccgaaatttgaagac ccat cgcgtctgaccacaacttccgccatatatttttcagcataattatagcttagacgagcaa aata tgagaacatactatgtctaggattagcaccgccactattagctgatgtcataacatcacc agca ttaagataccagtaattctcattggtcattgcttcatttggatatttatttcgtgttccg gcca taaactcataaacatctcttgatgcagaagtacctaacaggacagatgtagaatgttcac caaa agattttttatatcgcaatgtattctcccactgccaactactattagcatttgtactttg ttct accctagaattatcttctttacattctgcagaatgaaaaaactttggtgcaaacattctt ccac ggaaattccgatgattaataccaaaatctgtgcggaaaacaaggtctttaataaaagtga tctc agcataaacattaccaaaaaattgctgggtaatatttttattcttaggtgcctcatccat aaat gcaatagggttccacatacggctataaggtacaggagagactccatatccgaaagtatcg ttgc tattctcatcataaaccggagtagtaggatcaatattataggcgtatgatatcggattat aacc attgataccggttgccactccactattctctatatatgcatagttgacgtttgcacctac actt aagaaatcatttatagaataggaactgttcagccttgtgctgaatcgtttgtaaaatgac gcat cttcaccgataataccattctggtctagataattcaatgaaagcaagcttgaacccttat cact gccaaagttagcagtaatgttatgctcagtaacaggagctgtattcaatatttcattaaa ccag tctgtattataacctgttggagcagtaggtacaccaccggcaagcggcatatcatcattg tcgg caaactctttcatcagcataatgtactgttcatcattcagcatggttggtttctttgcta ctgt agagaaaccatagtaaccatcataagcaagcgatgtctttcctttctttcctttctttgt ggtt ataaggactacaccattagcggctctggcaccataaatagcagctgaagttgcatccttc aaga cttccatgctttcaatgtcgttgggatttacactgttcatgtcgtccataggcagtccgt caat tacaaaaagaggattagagtttccatttgtaccaacaccacgaattaccagcttcggtgc tgtt cctggctgaccggaatttgtcacaacgttcacaccactaaccctaccgctcaatgcattc acgg catttgctggtttagattgcaataaatcatcggaatcgatgctactgatagcacctgtta caac actttttttcttaacctcatatcctattgctacaacttcctcgagtgcaatggcagatgt tttt aattgaacgtctatcttagactgacctttatacactatattctgtgtatcatatcctacg aagc tataaatcaatgtcgattccattggtacattttccaagatataatttccgtccaaatcag aaat aataccgtttgtggtacctttaactaaaatacttgcacctatcacaggtaaaccatcgga gtct gttatacaaccggtaactttcccgttctgtgcatttaatggtaaactgaacgttataaga atca gcatacacattaatgatagtgttctgttcataatctagagttttttgtaattagtgtttt tctt aaaataaaaagttttgttctatcagttgcgcgctacttactgacacttgcaaatatatat acta tgtaatataaccaaagggggaaaatttcatttaaataggggggggaaatagattaactaa atat tttaaggaaaaatggctgttagaatccattcccagactccaacagccattttatcactaa caat cgcctgttaatcaatatatttttctgcccatttccttaagatttgcatccctgcccagtg gaac aaaagtaaatccgtatgaatagcttcccttcagaagacgcttgtctattgaaggacgggc tttc agactccagctatctgttccgcccactccagcctgaaccaggtcgatattaagagtatta gaat acaagtccttttcaagttcatttatatgtttagccttatcaatcgcattctgcgacatct ccca cactgaaacagataggggttcatcgccgacaatcatcacacctgccttatccgactgcaa ggca aaccatctcacgtcacaacggtttccgttttcctgcggcattacatagtcaaatcccaga gcgg acaccttgcagttatatatagacaccattgcagaggcttttctgtcggaatagttttccc atgg gccacgtccataatatgtcacatccgacaaacgattggtacattcgcattgcaatcctac gcgc aacatttctgatatttcaggagacttcatcattgaataatgaacgcctattgttccgtct gctt ttactttataattcaaggtaagtctcagtctttcatctatagcctttagcaccttaacct caag attgccttccgatttgcgtacatctatagaaactgtctttagctttaatggagcatcttt ccag aatgcaaacagtctatcgaccttccatcctcgccagtcattgtctgttgacgctctccag aagt ttggtttcagagcagatgtgatgatactttcattatctatcttatactgactgatataac catc actgatattcagataaaagttctttcccttcacgctgatgtctttcttgttatctgaatc gatt tccatatccaatgtagtatcaacgcattctactatctttggtaaagaaagatacttaaac tgtt cccaggcaacctcgtatccagctttggcatacagattgtcattcttgagcctggcactca ggaa taaccaatattccgcaccgtcatcggccttgaaattctgaataggaagttttagtttaca gctc tcaccagctggtgttgtcggcacaataatctcaccttcctgcaatacactgtcttcgtcc ttca attgccaaaaataacgatactcatctgttgaaaggaagaagtttctgttttttacagtta tctc tccactatagacattatcagttgtaaatgatacaggagcaaacacgtacttgcattcctc agta gcaggtttaatggagcggtcggcactgataacaccatttatacagaagttttggtcgttg tgct cccctttctcatagtcaccaccataattccatgatttcttattatatttccgttcattat ccag caatccctggtctatccagtcccaaatatatccgccggcaagcgcatcatgagaacgtat tgca tcccagtattctttcagcccgccggtagagtttcccatagaatgtgcatattcacacatt atta tcggacggttcatgaccggattcttagtcattgctataagctcatcgaccataggataca tacg gctaatgacatcgacgtataaaggatcatcgggattggcatacacacaaagctctttctt tgcc ggtttgacatcttcgttcacattaaaatctatctcactagtaacgattgacgcttcctta cgtc cgataggtttgtataaaggattttccggctgtccttgcgccccctcgtaatgaacaggac gggt tgggtcataatctttcagccatcctgacagagctgcatgattagggccgcatccagactc gttg cccaacgaccacataaacacagaaggatggttcctgtctctcacagccattcttaccact ctct ccatgaacgagttagcccactcaggcctattggacagataccccctttgatgatgagttt caag attagcctcatccattacgtatataccatacttatcgcacagttcatagaaataagggtc gtta ggatagtgcgatgtacggactgtattgaagttataacgcttcataagcagaacgtcttcg agca tctcatcacgtgtaacggtcttacctccggtctcgctatggtcatggcggtttacaccaa tgag tttaataggagtgtcattcaccagaatctgattacctgttattttaatatccctgaaccc tacc ttattacttctcgcatccaccacgttgccctttttgtctgtgagctttataaccaaagtg tata gataagggtgttccgaattccatagttttggcttagaaacaattccctccatcattccgt aata aacattatcacgctgaggataaggttcgttcaccacataatcggcagtaacggtaatgtc tttt ccaaacaccggtttcccatcggcatcatataattgggctgacagattccatcccttcaaa tcat ccatattctgatttgttatttccggacggatctgtaaccgtgctatattcttccggaaat cgat gcgtgtccttactccataatcatatattgccacctgcggaatggacatgatatatacttc acga tggataccagccattcgccagtggtcggcatcttccatataacttccgtcggtccactta taca cttgcaccgccagtttattctcccccttcttaacgtattcggtaatatcaaattcagtag gcag acaactgtcttcggaatatcccaccttctgtccgtttatccatacattaaatcccgaata gacg cctccgaaatggagtataatcctgtcgctcttccacttgtcaggaacaacaaactccttg atat aacaccccgtctgattattcctgtcaatatatggcggacgagcagggaaaggataaatag tatt tgtatatataggatagccatatccctgcatctcccaacatgaaggaacaggaatagtttt ccat gatgatgaattgtactccactttataaaaaccggcgggagccaatgccatatcctcggaa aagt taaacttccattggccgttcaacgacatatactccgatttctctctgtctccatccaaag ccca atccactctccggaaagaataagtagtactgcgggaaggcaaacggttaattccgtttat ggtc tgatcctgccatacattctgattgtttctccactgattggcaccgttgtccgatgcagac agaa attgcatcatgaaaaataacacagaaaatgaaaaaatagattttaagttcaagttcataa attc gcattttaagtttctatgcaaatatataagtataacgaacaatgaatagggggtatttct atct atatagagtggtatttttacatatgagctaaaacttaaaaaaaactgtcagtattactat gcta tgtagcactctatatgaaaatattatatattcccaagtcaaaagccttttcaaacaattt ttat atattctcatcctatcccttccatcaaagataaattccaatcctgatttgccagccgcat ttat tccttttttcaggagaattttctttatggctatcgccatgaaaattcacctgaaaaagaa tgcg gcggcaaacggattagaattaaagaaaagattacagggattaactgcgaccgacgtgacg cata gccgtaattcaaaggcggctatccttatattccatatatgacctcacaaatactgtgaaa atcc actttccccaataacaaaacatagcctgccatatcaacacccaaaa [00230] SEQ ID NO: 74 (pZR1622 - chloramphenicol resistance vector):

ACTAGAGATCTATGTGAGGATCCTAACTCGAGATCGAGACTGCTATGACTTGAGACC GGCTATT ACGAGCGCTTAAACGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGTTTCA TCAG CCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCAGGAT TCCC GTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGGGTGG GCCT ACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACGAACC CTTT GGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATAATGA CCCC GAAGCAGGGTTATGCAGCGGAAAAGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTT TCGT TTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATT TAAA GTTTCACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAG CCTG GATCACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAA TATT AACAATAATTTATTTTCAATGGAGAAAAAAATCACTGGATATACCACCGTTGATATATCC CAAT GGCATCGTAAAGAACATTTTGAGGCATTTCAGTCAGTTGCTCAATGTACCTATAACCAGA CCGT TCAGCTGGATATTACGGCCTTTTTAAAGACCGTAAAGAAAAATAAGCACAAGTTTTATCC GGCC TTTATTCACATTCTTGCCCGCCTGATGAATGCTCATCCGGAATTTCGTATGGCAATGAAA GACG GTGAGCTGGTGATATGGGATAGTGTTCACCCTTGTTACACCGTTTTCCATGAGCAAACTG AAAC GTTTTCATCGCTCTGGAGTGAATACCACGACGATTTCCGGCAGTTTCTACACATATATTC GCAA GATGTGGCGTGTTACGGTGAAAACCTGGCCTATTTCCCTAAAGGGTTTATTGAGAATATG TTTT TCGTTTCAGCCAATCCCTGGGTGAGTTTCACCAGTTTTGATTTAAACGTGGCCAATATGG ACAA CTTCTTCGCCCCCGTTTTCACCATGGGCAAATATTATACGCAAGGCGACAAGGTGCTGAT GCCG CTGGCGATTCAGGTTCATCATGCCGTTTGTGATGGCTTCCATGTCGGCAGAATGCTTAAT GAAT TACAACAGTACTGCGATGAGTGGCAGGGCGGGGCGTAAGGTTCCTAGCTGATTAGAAGGC CATC CTGACGGATGGCCTTTTTTTTTGATAATAAGCGGATGAATGGCAGAAATTCGACGAGTCA TTGG TAACTATCTATGAAACTGTTTGATACTTTTATAGTTGATTAAACTTGTTCATGGCATTTG CCTT AATATCATCCGCTATGTCAATGTAGGGTTTCATAGCTTTGTAGTCGCTGTGTCCCGTCCA TTTC ATGACCACCTGTGCCGGGATTCCGAGAGCCAGCGCATTGCAGATGAATGTCCTTTTTCCT GCAT GGGTACTGAGCAAAGCGTATTTGGGTGTGACTTCATCAATACGTTCATTTCCCTTGTAGT AGGT TTCCCGTACAGGCTCGTTGATTTCTGCCAGTTCGCCCAGCTCTTTCAGGTAATCGTTCAT CTTC TGGTTGCTGATGACGGGCAGAGCCATGTAATTCTCGAAATGGATGTCCTTGTATTTGTCC AGTA TGGCTTTGCTGTATTTGTTCAGTTCAATCGTCAGGCTGTCGGCAGTCTTGACTGTGGTTA TTTC GATGTGGTCGGACTTCACATCGCTTCTTTTCAGATTGCGAACATCCGAATACCGCAAACT CGTA AAGCAGCAGAACAGGAAAACATCACGCACACGTTCCAGGTATTGCTTATCCTTGGGTATC TGGT AGTCTTTCAGCTTGTTCAGTTCATCCCAAGTCAGGAAGATTACTTTTTTCGAGGTGGTTT TCAG TTTCGGTTTGAACGTATCGTATGCAATGTTCTGATGATGTCCTTTCTTGAAGCTCCAGCG CAGG AACCATTTGAGGAATCCCATTTGCTTGCCGATGGTGCTGTTTCTCATATCCTTGGTGTCA CGCA GGAAGTTGACGTATTCGTTCAATCCAAACTCGTTGAAATAGTTGAACGTTGCATCCTCCT TGAA CTCTTTGAGGTGGTTCCTCACTGCTGCAAATTTTTCATAGGTGGATGCCGTCCAGTTATT CTGG TTACCGCACTCTTTTACAAACTCATCGAACACCTCCCAAAAGCTGACAGGGGCTTCTTCC GGCT GTTCTTCACTGGTATCTTTCATTCTCATGTTGAAAGCTTCCTTCAACTGTTGGGTCGTTG GCAT GACCTCCTGCACCTCAAATTCCTTGAAAATATTCTGGATTTCGGCATAGTATTTCAGCAA GTCC GTATTGATTTCGGCTGCACTTTGCTTTAGCTTGTTGGTACATCCGTTCTTTACCCGCTGC TTAT CTGCATCCCATTTGGCTACGTCAATCCGGTAGCCCGTTGTAAACTCGATACGTTGGCTGG CAAA GATGACACGCATACGGATGGGTACGTTCTCTACGATTGGCACACCGTTCTTTTTCCGGCT CTCC AATGCAAAAATGATGTTGCGCTTGATATTCATAATTGGGTGCGTTTGAAATTCTACACCC AAAT ATACACCCAATTATTGAGATAGCAAAAGACATTTAGAAACATTTACTTTTACTCTATATT GTAA TTTACACTTGATTATCAGTCGTTTGCAGTCTTATGATATTCTGTGAAAGTATAAGTTCGA GAGC CTGTCTCTCCGCAAAAAACGCTGAAAATCAGCAGATTGCAAAACAAACACCCTGTTTTAC ACCC AAGAATGTAAAGTCGGGTGTTTTTGTTTTATTTAAGATAATACAACCACTACATAATAAA AGAG TAGCGATATTAAAAGAATCCGATGAGAAAAGACTAATATTTATCTATCCATTCAGTTTGA TTTC TCAGGACTTTACATCGTCCTGAAAGTATTTGTTGCCAGTGTTACAACCAATTAACCAATT CTGA TTAGAAAAACTCATCGAGCATCAAATGAAACTGCAATTTATTCATATCAGGATTATCAAT ACCA TATTTTTGAAAAAGCCGTTTCTGTAATGAAGGAGAAAACTCACCGAGGCAGTTCCATAGG ATGG CAAGATCCTGGTATCGGTCTGCGATTCCGACTCGTCCAACATCAATACAACCTATTAATT TCCC CTCGTCAAAAATAAGGTTATCAAGTGAGAAATCACCATGAGTGACGACTGAATCCGGTGA GAAT GGCAAAAGCTTATGCATTTCTTTCCAGACTTGTTCAACAGGCCAGCCATTACGCTCGTCA TCAA AATCACTCGCATCAACCAAACCGTTATTCATTCGTGATTGCGCCTGAGCGAGGCGAAATA CGCG ATCGCTGTTAAAAGGACAATTACAAACAGGAATCGAATGCAACCGGCGCAGGAACACTGC CAGC GCATCAACAATATTTTCACCTGAATCAGGATATTCTTCTAATACCTGGAATGCTGTTTTC CCGG GGATCGCAGTGGTGAGTAACCATGCATCATCAGGAGTACGGATAAAATGCTTGATGGTCG GAAG AGGCATAAATTCCGTCAGCCAGTTTAGTCTGACCATCTCATCTGTAACATCATTGGCAAC GCTA CCTTTGCCATGTTTCAGAAACAACTCTGGCGCATCGGGCTTCCCATACAATCGATAGATT GTCG CACCTGATTGCCCGACATTATCGCGAGCCCATTTATACCCATATAAATCAGCATCCATGT TGGA ATTTAATCGCGGCCTGGAGCAAGACGTTTCCCGTTGAATATGGCTCATAACACCCCTTGT ATTA CTGTTTATGTAAGCAGACAGTTTTATTGTTCATGATGATATATTTTTATCTTGTGCAATG TAAC ATCAGAGATTTTGAGACACAACGTGGCTTTGTTGAATAAATCGAACTTTTGCTGAGTTGA AGGA TCAGCCGCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCATGTTTCACGTACTAA GCTC TCATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTCATGGCTAACGTACT AAGC TCTCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTGAACAA TAAA ATTAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAA GAAT ATATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACAAGCCAGGGATGTAA CGCA CTGAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGGAACACTTAACGGCT GACA TGGGGCGGCCGCTCAACGTACCGGTCTCAGTAGGGAGAGCTGTATGTGGGTAG [00231] SEQ ID NO: 75 (pZR0879 - Ec_frc, Of_oxc, Sc_YBR222C, Sc_YEL020C, Ec_yfdE, Of_oxlT (high-strength promoter) expression vector):

GGAGAGCTGTATGTGGGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTT CGTTTTA CAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAA GTTT CACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTG GATC ACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATATT AACA ATAATTTATTTTCAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTG TGCA ATCTGGCCCATCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGA ACGT CCCGGCGTTGGTGACGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTT TACT TCACCATGCTTAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCA AAGA GGTAATGGAAAAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGC CATT GATCACATGGGCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGT TCGA TCAAAGGGTTTGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTC AGGC TTGGGTGACAGCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCAT CGCG AAAAAACGGGGCGTGGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTT GCCG CGTGAAATTACGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCA GTAT CCGAATGGTACATTTGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAG CCTG GCTGGATCCTGAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTA TTCA GGAGCAAAACTGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCC GGCA TACAGTACAGCCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAA TACA CTGTCACTATTGATAAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTG CACC GGTTTTAAGTATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGT TGAA GTGGAACAACCGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCC TTTA CGCCGGATATTAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGC TGGG TTATAGCGACGATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTAGCT GATT AGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTGGTAAGCCAATCTAGGGCCTCGTC TGTA GGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTT TTTT TTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAA ATAA TGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGAGCTGTCACCGGATGTGCT TTCC GGTCTGATGAGTCCGTGAGGACGAAACAGCCTCTACAAATAATTTTGTTTAATCCATCAA TTTA AAATTTAAAATAATGGTTTTTACTCTGGAAGATTTTGTTGGCGATTGGCGTCAGACCGCG GGTT ATAATTTGGATCAAGTCCTGGAACAGGGTGGCGTAAGCTCTCTGTTCCAGAACCTGGGTG TGAG CGTGACGCCGATTCAGCGCATCGTTCTGTCCGGCGAGAACGGTCTGAAAATTGATATTCA TGTG ATCATCCCGTACGAAGGCCTGAGCGGTGACCAAATGGGTCAAATCGAGAAAATCTTTAAA GTCG TCTACCCAGTTGACGATCACCACTTCAAGGTTATCTTGCATTACGGTACGCTGGTGATTG ATGG TGTGACCCCGAATATGATTGACTATTTCGGCCGTCCGTATGAAGGCATTGCCGTTTTTGA CGGT AAAAAGATCACCGTCACCGGTACCCTGTGGAATGGCAATAAGATTATTGACGAGCGTCTG ATTA ACCCGGACGGCAGCCTGCTGTTCCGCGTGACCATCAACGGTGTCACGGGTTGGCGTCTGT GCGA GCGCATCCTGGCAGGTTCAATGAGTAACGACGACAATGTAGAGTTGACTGATGGCTTTCA TGTT TTGATCGATGCCCTGAAAATGAATGACATCGATACCATGTATGGTGTTGTCGGCATTCCT ATCA CGAACCTGGCTCGTATGTGGCAAGATGACGGTCAGCGTTTTTACAGCTTCCGTCACGAAC AACA CGCAGGTTATGCAGCTTCTATCGCCGGTTACATCGAAGGAAAACCTGGCGTTTGCTTGAC CGTT TCCGCCCCTGGCTTCCTGAACGGCGTGACTTCCCTGGCTCATGCAACCACCAACTGCTTC CCAA TGATCCTGTTGAGCGGTTCCAGTGAACGTGAAATCGTCGATTTGCAACAGGGCGATTACG AAGA AATGGATCAGATGAATGTTGCACGTCCACACTGCAAAGCTTCTTTCCGTATCAACAGCAT CAAA GACATTCCAATCGGTATCGCTCGTGCAGTTCGCACCGCTGTATCCGGACGTCCAGGTGGT GTTT ACGTTGACTTGCCAGCAAAACTGTTCGGTCAGACCATTTCTGTAGAAGAAGCTAACAAAC TGCT CTTCAAACCAATCGATCCAGCTCCGGCACAGATTCCTGCTGAAGATGCTATCGCTCGCGC TGCT GACCTGATCAAGAACGCCAAACGTCCAGTTATCATGCTGGGTAAAGGCGCTGCATACGCA CAAT GCGACGACGAAATCCGCGCACTGGTTGAAGAAACCGGCATCCCATTCCTGCCAATGGGTA TGGC TAAAGGCCTGCTGCCTGACAACCATCCACAATCCGCTGCTGCAACCCGTGCTTTCGCACT GGCA CAGTGTGACGTTTGCGTACTGATCGGCGCTCGTCTGAACTGGCTGATGCAGCACGGTAAA GGCA AAACCTGGGGCGACGAACTGAAGAAATACGTTCAGATCGACATCCAGGCTAACGAAATGG ACAG CAACCAGCCTATCGCTGCACCAGTTGTTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCG CAAA GCACTGAAAGGCGCTCCAAAAGCTGACGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTT GACG GCAACAAAGCCAAACTGGCTGGCAAGATGACTGCCGAAACCCCATCCGGAATGATGAACT ACTC CAATTCCCTGGGCGTTGTTCGTGACTTCATGCTGGCAAATCCGGATATTTCCCTGGTTAA CGAA GGCGCTAATGCACTCGACAACACTCGTATGATTGTTGACATGCTGAAACCACGCAAACGT CTTG ACTCCGGTACCTGGGGTGTTATGGGTATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTG TTAC CGGCAAACCGGTTATCGCTGTTGAAGGCGATAGCGCATTCGGTTTCTCCGGTATGGAACT GGAA ACCATCTGCCGTTACAACCTGCCAGTTACCGTTATCATCATGAACAATGGTGGTATCTAT AAAG GTAACGAAGCAGATCCACAACCAGGCGTTATCTCCTGTACCCGTCTGACCCGTGGTCGTT ACGA CATGATGATGGAAGCATTTGGCGGTAAAGGTTATGTTGCCAATACTCCAGCAGAACTGAA AGCT GCTCTGGAAGAAGCTGTTGCTTCCGGCAAACCATGCCTGATCAACGCGATGATCGATCCA GACG CTGGTGTCGAATCTGGCCGTATCAAGAGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAAT AAGG TTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTGCGTTCCTGGC GTGG TGCTCGCATAGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACA ATTG GGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCA CTTG AACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGGATCAC ACAA CATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATATTAACAAT AATT TATTTTCAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTAGCGTAT CCGA TAATGTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCTATCCCA CATG GTGGGTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCTGTTTTC AGAC AAGATACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCCTCGGTG CTAC TATGGACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTTCAATTT TTAT TTGAATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTACAGAGT TCTG AAATTCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCGATGCGA CCAG GTTTAGGGTAGAGTATGATATATACTCTCCAGAGGACAACTACAAAAGGGTTATTTACCG GTCT TTGAACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCCCGTTCC AGTG ACGTTGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGCCTTTGT TACA TTTGAACATTGTGAGAAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCCCTTGGA CAGA TCTTATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTTTCCACT TTTA GAACTCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGGACCAAT TTGT TAAGTACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCTGAACAT GCCC AAACCAAACCCTTTCCCACACATTAGATTCATCAGATCGTGTTCTTCTGCTTTGGCTCCA GCAA CGTTCCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGATGACCG AAGC ATCACATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTACTGTGGG CCAG CCACAAGGAGTCACCGTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCGGGCAAA GTCG GCGAAGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAAAAGCTA ACAA GGAGAACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTTCGACCC TGAG GGGTTTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAAAAGATT TCAC CCATTGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTGCATTTG GTGT TCCCGACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGGAGAAAA AATG ACCTACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATTCCAACC AAGG TGTACTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAGTTATCG CAGA AACTTTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGGTTCCTAGCTGATTAGAAG GCCA TCCTGACGGATGGCCTTTTTTTTGACTGCCCGACGAACGGACTAATCCTGACGTAGGATA AAAC GAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTT TTGT TTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTC TTAT ATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGGATCACACAACATTTAAAAAATAACATT ATGA AAGCACTCGAAAAGAGATTCAAAGGTAATATTAACAATAATTTATTTTCAATGACCACGA CCGC TACCCAACACTTCGCTCAACTTTTACAAAAATATGGCATCGACACAGTCTTTGGAATTGT GGGC ATCCCTATTGTCCAACTAGCGGATACGATGGTTGCCAACGGTATCAAATTCATTCCATGC AGGA ACGAACAGGCTGCCTCATATGCAGCCTCTGCTTATGGTTATATTAGTGATAAGCCCGGCG TGTT ACTTATTGTCGGGGGCCCCGGTTTAATCCACGCACTGGCTGGTATATACAACTCAATGAG TAAT AGGTGGCCTCTTCTAGTAATTGCAGGGAGTTCTTCTCAAAGTGATATACATAAAGGCGGG TTTC AAGAGTTGGATCAAGTTAGTCTTTTGTCCCCATTTTTGAAGTTTACCGGAAAGTTAACCC CTGA CAATATTGACATGATTACTCAGAAGGCTTTGAATTACTGTATACAAGGCACTGCAGGGGT TTCT TACATAGACGTCCCTGCAGATTTTATTGAGTATGAAAAACCCTTAGAAGGAAACGACCGT ACAG GAAATGAATTACCGATGATATTAACTCCAAACATATGTGGCCCTGATCCGTCGAAGATCA AAAA AGTCGTACAGCTTATTTTGCAACATAAAAATAAAAATATTCTGATTGTTATTGGAAAGGG TGCG GTAAAAAACTCACACGAAATCCGCAGACTAGTAAATACGTTCAATCTACCATTTTTACCC ACCC CAATGGCTAAGGGAATTGTCCCAGACTCTTCTCCACTGAACGTTTCATCTGCAAGATCTC AAGC ATTGAAAATAGCGGATATTGTTCTTGTTCTCGGGGCAAGATTAAACTGGATATTGCATTT TGGT ACTTCACCCAAATGGAACTCAGAATCCATATTCATCCAGTTCGATTCCAATCCCGAAACC TTGG GGGATAACAATGTCTCACCTGGTGCTGACCTTTCCATATGGGGAGATATAGGCTTGAGCG TAAC CGCTTTAGTTGAGGAATTGACTCGCCAAGATTCCTGCTGGAAGTATAGTGGTGTTAAGCA AGAA ATACGAGAGAAAATTCAACTGAATCAAACTCGTCTATTGAGGAAAGAGAAGACTAGAGGG GCAC AATTGAATTACAACCAGGTTTATGGAACATTGAGGCCTCTTATCGATGATTACAGGACAA TACT TGTGACGGAGGGAGCAAATACTATGGATATTGCGCGTATTTCATTCCCTACAGACGCTCC AAGG CGCCGTTTAGACGCAGGGACCAACGCGACTATGGGGATTGGGCTCGGATATGCTCTTGCA TGCA AGGCATCTCATCCGGAACTCGATGTGGTGCTGATTCAGGGTGATTCCGCATTTGGATTCT CTGC CATGGAAATTGAAACGGCAGTAAGGTGTCAGCTGGCATTGGTCATCGTTGTGATGAACAA TAGC GGTATTTACCATGGAGAAAAGGATATAGAGGGTGATTTACCTCCAACGGCACTAAGCAAG AACT GCCGTTACGATCTCGTAGGCAAAGGACTGGGTGCCAATGATTTTTTTGTCAACACAATAA GCGA ACTGAGCAGATGCTTCCAACAAGCCGTGCAGCTTTCTCGGACTAAAAGAGAAACAAGTGT CATC AACGTTATCATTGAGCCTGGCGAACAAAAGCAAATTGCCTTTGCCTGGCAGAATAAACCG CGTT TATAGGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTGCTC TGGG TCTGACGGCCATCAAGGGTAGTGAGACTAGCTGATTAGAAGGCCATCCTGACGGATGGCC TTTT TTTTGACTGGGTGTTCCGATACACTCAATTTGTGTAGGATAAAACGAAAGGCTCAGTCGA AAGA CTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATC TATT GTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAA AGAA ACAAAGTAGCCTGGATCACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAAAGA GATT CAAAGGTAATATTAACAATAATTTATTTTCAATGACAAATAATGAAAGCAAAGGGCCGTT TGAA GGCTTATTAGTTATCGATATGACACATGTCCTTAATGGACCTTTCGGAACTCAACTTCTT TGTA ATATGGGCGCAAGGGTAATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACCCGCACAT TTGG TCCCTATGTGGATGGACAGTCACTCTATTACAGTTTTATTAATCATGGCAAAGAGAGTGT GGTT CTTGATTTAAAGAATGATCACGATAAAAGTATATTTATAAATATGCTCAAACAAGCTGAT GTAT TAGCTGAGAATTTTCGCCCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAAACGCTTC AAGA AATCAACCCGCGCCTCATATATGCTTCATCGTCAGGTTTCGGACATACCGGTCCGCTAAA AGAT GCTCCTGCCTACGATACCATCATTCAGGCAATGAGCGGGATAATGATGGAAACAGGATAT CCTG ATGCTCCGCCAGTGCGCGTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTCTATTTAT TCAG CGGAATAGTGAGTGCACTTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATGTCGATAT AGCG ATGTTTGATGCCACGCTGAGTTTTCTGGAGCATGGTCTGATGGCATATATCGCAACTGGG AAGT CACCACAACGTCTGGGAAATCGCCATCCCTACATGGCACCTTTTGATGTTTTCAATACTC AGGA TAAGCCGATTACGATTTGTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCCAGGCACT GGAG CTTACGGAACTGGTTAATGATCCCCGATTTAGCAGCAATATTTTACGCGTACAAAACCAG GCTA TTCTTAAACAATATATTGAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGGTTAGCCA GAAT ACATGAAGTTGGTGTACCCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTAAATTGCC ACAA ACTCAGGCGAGAAATATGTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAATCCGATA AAAA TCAGCGGCTGCGCGGACCCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAGCATGGGG AACA AATTCGCCAGGAGTTCTCATCATAAGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGAT GGCC TTTTTTTTGACTTAGTTTCAATTTTACATTCCAGGAAGTAGGATAAAACGAAAGGCTCAG TCGA AAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTT AATC TATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGT CGAA AGAAACAAAGTAGCCTGGATCACACAACATTTAAAAAATAACATTATGAAAGCACTCGAA AAGA GATTCAAAGGTAATATTAACAATAATTTATTTTAATGAATAATCCACAAACAGGACAATC AACA GGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAGCAGTTTTGCTGATGTGTATGATC TCGG GTGTCCAATATTCCTGGACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTTCTT TGGC TGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGGTGG TGGT TACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTTCTC GCTG GCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTCTGG CCGG TGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCCGGA CAAA CGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTCCTG CCAC TGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTTTGA TCAT GGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGCCAA AAAA CAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAATTC TGGG TTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACAGCG TCCC TTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCAGAA CCTG TTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTACAAA ACCA TGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTGCCT TGGG CGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTACGC TCTG TTCCCATCGACCAACAGCGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGTTTC TTCT GGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAACCA ACTT CGGATGGAATACCGCTTTCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCTGGC TACC TTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAAGAA AAAG CTGTACATTAAGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGA CTGC TATGACTAAACGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGTTTCATCA GCCA TCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCAGGATTCC CGTT GAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGGGTGGGCC TACT TCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACGAACCCTT TGGC AAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATAATGACCC CGAA GCAGGGTTATGCAGCGGAAAAGTTATATACATTCATGTCCATTTATGTAAAAAATCCTGC TGAC CTTGTTTATGTCTTGTCAGTCACCATTTGCAAAACCATATTTGACCCTCAAAGAGGCTGA ATTT GATAAGCAACTTGCTACATACTCATAATAAGGAGCTAAATAGAACACGAATGGGAAATAC TCAA ATGCCAAACTAAAGAAGATATTGGCCAAAATAAACGCTATACCGAGAGAGAAACTTGATT TTTC AACTTCCTAAAACAGTGTTGTTCAAACATTTCTACTTATTTGTACTTACCAGTTGAACCT ACGT TTCCCTAATAAAATGTCTATGGTAAAAAGTTAAAAAATCCTCCTACTTTTGTTAGATATA TTTT TTTGTGTAATTTTGTAATCGTTATGCGGCAGTAATAATATACATATTAATACGAGTTAGG AATC CTGTAGTTCTCATATGCTACGAGGAGGTATTAAAAGGTGCGTTTCGACAATGCATCTATT GTAG TATATTATTGCTTAATCCAAATGAATATTATAAATTTAGGAATTCTTGCTCACATTGATG CAGG AAAAACTTCCGTAACCGAGAATCTGCTGTTTGCCAGTGGAGCAACGGAAAAGTGCGGCTG TGTG GATAATGGTGACACCATAACGGACTCTATGGATATAGAGAAACGTAGAGGAATTACTGTT CGGG CTTCTACGACATCTATTATCTGGAATGGTGTGAAATGCAATATCATTGACACTCCGGGAC ACAT GGATTTTATTGCGGAAGTGGAGCGGACATTCAAAATGCTTGATGGAGCAGTCCTCATCTT ATCC GCAAAGGAAGGCATACAAGCGCAGACAAAGTTGCTGTTCAATACTTTACAGAAGCTGCAA ATCC CGACAATTATATTTATCAATAAGATTGACCGAGCCGGTGTGAATTTGGAGCGTTTGTATC TGGA TATAAAAGCAAATCTGTCTCAAGATGTCCTGTTTATGCAAAATGTTGTCGATGGATCGGT TTAT CCGGTTTGCTCCCAAACATATATAAAGGAAGAATACAAAGAATTTGTATGCAACCATGAC GACA ATATATTAGAACGATATTTGGCGGATAGCGAAATTTCACCGGCTGATTATTGGAATACGA TAAT CGCTCTTGTGGCAAAAGCCAAAGTCTATCCGGTGCTACATGGATCAGCAATGTTCAATAT CGGT ATCAATGAGTTGTTGGACGCCATCACTTCTTTTATACTTCCTCCGGCATCGGTTTCAAAC AGAC TTTCATCTTATCTTTATAAGATAGAGCATGACCCCAAAGGACATAAAAGAAGTTTTCTAA AAAT AATTGACGGAAGTCTGAGACTTCGAGATGTTGTAAGAATCAACGATTCGGAAAAATTCAT CAAG ATTAAAAATCTAAAAACTATCAATCAGGGCAGAGAGATAAATGTTGATGAAGTGGGCGCC AATG ATATCGCGATTGTAGAGGATATGGATGATTTTCGAATCGGAAATTATTTAGGTGCTGAAC CTTG TTTGATTCAAGGATTATCGCATCAGCATCCCGCTCTCAAATCCTCCGTCCGGCCAGACAG GCCC GAAGAGAGAAGCAAGGTGATATCCGCTCTGAATACATTGTGGATTGAAGATCCGTCTTTG TCCT TTTCCATAAACTCATATAGTGATGAATTGGAAATCTCGTTATATGGTTTAACCCAAAAGG AAAT CATACAGACATTGCTGGAAGAACGATTTTCCGTAAAGGTCCATTTTGATGAGATCAAGAC TATA TACAAAGAACGACCTGTAAAAAAGGTCAATAAGATTATTCAGATCGAAGTGCCGCCCAAC CCTT ATTGGGCCACAATAGGGCTGACTCTTGAACCCTTACCGTTAGGGACAGGGTTGCAAATCG AAAG TGACATCTCCTATGGTTATCTGAACCATTCTTTTCAAAATGCCGTTTTTGAAGGGATTCG TATG TCTTGCCAATCCGGGTTACATGGATGGGAAGTGACTGATCTGAAAGTAACTTTTACTCAA GCCG AGTATTATAGCCCGGTAAGTACACCAGCTGATTTCAGACAGCTGACCCCTTATGTCTTTA GGCT GGCCTTGCAACAGTCAGGTGTGGACATTCTCGAACCGATGCTCTATTTTGAGTTGCAGAT ACCC CAAGCGGCAAGTTCCAAAGCTATTACAGATTTGCAAAAAATGATGTCTGAGATTGAAGAT ATCA GTTGCAATAATGAGTGGTGTCATATTAAAGGGAAAGTTCCATTAAATACAAGTAAAGACT ATGC ATCAGAAGTAAGTTCATACACTAAGGGCTTAGGCATTTTTATGGTTAAGCCATGCGGGTA TCAA ATAACAAAAGGCGGTTATTCTGATAATATCCGCATGAACGAAAAAGATAAACTTTTATTC ATGT TCCAAAAATCAATGTCATCAAAATAACCACGAGTCATTGGTAACTATCTATGAAACTGTT TGAT ACTTTTATAGTTGATTAAACTTGTTCATGGCATTTGCCTTAATATCATCCGCTATGTCAA TGTA GGGTTTCATAGCTTTGTAGTCGCTGTGTCCCGTCCATTTCATGACCACCTGTGCCGGGAT TCCG AGAGCCAGCGCATTGCAGATGAATGTCCTTTTTCCTGCATGGGTACTGAGCAAAGCGTAT TTGG GTGTGACTTCATCAATACGTTCATTTCCCTTGTAGTAGGTTTCCCGTACAGGCTCGTTGA TTTC TGCCAGTTCGCCCAGCTCTTTCAGGTAATCGTTCATCTTCTGGTTGCTGATGACGGGCAG AGCC ATGTAATTCTCGAAATGGATGTCCTTGTATTTGTCCAGTATGGCTTTGCTGTATTTGTTC AGTT CAATCGTCAGGCTGTCGGCAGTCTTGACTGTGGTTATTTCGATGTGGTCGGACTTCACAT CGCT TCTTTTCAGATTGCGAACATCCGAATACCGCAAACTCGTAAAGCAGCAGAACAGGAAAAC ATCA CGCACACGTTCCAGGTATTGCTTATCCTTGGGTATCTGGTAGTCTTTCAGCTTGTTCAGT TCAT CCCAAGTCAGGAAGATTACTTTTTTCGAGGTGGTTTTCAGTTTCGGTTTGAACGTATCGT ATGC AATGTTCTGATGATGTCCTTTCTTGAAGCTCCAGCGCAGGAACCATTTGAGGAATCCCAT TTGC TTGCCGATGGTGCTGTTTCTCATATCCTTGGTGTCACGCAGGAAGTTGACGTATTCGTTC AATC CAAACTCGTTGAAATAGTTGAACGTTGCATCCTCCTTGAACTCTTTGAGGTGGTTCCTCA CTGC TGCAAATTTTTCATAGGTGGATGCCGTCCAGTTATTCTGGTTACCGCACTCTTTTACAAA CTCA TCGAACACCTCCCAAAAGCTGACAGGGGCTTCTTCCGGCTGTTCTTCACTGGTATCTTTC ATTC TCATGTTGAAAGCTTCCTTCAACTGTTGGGTCGTTGGCATGACCTCCTGCACCTCAAATT CCTT GAAAATATTCTGGATTTCGGCATAGTATTTCAGCAAGTCCGTATTGATTTCGGCTGCACT TTGC TTTAGCTTGTTGGTACATCCGTTCTTTACCCGCTGCTTATCTGCATCCCATTTGGCTACG TCAA TCCGGTAGCCCGTTGTAAACTCGATACGTTGGCTGGCAAAGATGACACGCATACGGATGG GTAC GTTCTCTACGATTGGCACACCGTTCTTTTTCCGGCTCTCCAATGCAAAAATGATGTTGCG CTTG ATATTCATAATTGGGTGCGTTTGAAATTCTACACCCAAATATACACCCAATTATTGAGAT AGCA AAAGACATTTAGAAACATTTACTTTTACTCTATATTGTAATTTACACTTGATTATCAGTC GTTT GCAGTCTTATGATATTCTGTGAAAGTATAAGTTCGAGAGCCTGTCTCTCCGCAAAAAACG CTGA AAATCAGCAGATTGCAAAACAAACACCCTGTTTTACACCCAAGAATGTAAAGTCGGGTGT TTTT GTTTTATTTAAGATAATACAACCACTACATAATAAAAGAGTAGCGATATTAAAAGAATCC GATG AGAAAAGACTAATATTTATCTATCCATTCAGTTTGATTTCTCAGGACTTTACATCGTCCT GAAA GTATTTGTTGCCAGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCA TCAA ATGAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTT CTGT AATGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCT GCGA TTCCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTAT CAAG TGAGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTC TTTC CAGACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAA CCGT TATTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGACAAT TACA AACAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACC TGAA TCAGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAAC CATG CATCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCC AGTT TAGTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAA CAAC TCTGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTA TCGC GAGCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGGAGC AAGA CGTTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAG TTTT ATTGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACA ACGT GGCTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGCCGCGCAGTTCAACCT GTTG ATAGTACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTAACGTACTAAGC TCTC ATGTTTAACGAACTAAACCCTCATGGCTAACGTACTAAGCTCTCATGGCTAACGTACTAA GCTC TCATGTTTCACGTACTAAGCTCTCATGTTTGAACAATAAAATTAATATAAATCAGCAACT TAAA TAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAAGAATATATAAGGCTTTTAAAGCTT TTAA GGTTTAACGGTTGTGGACAACAAGCCAGGGATGTAACGCACTGAGAAGCCCTTAGAGCCT CTCA AAGCAATTTTGAGTGACACAGGAACACTTAACGGCTGACATGGGGCGGCCGCTCAAGTAG [00232] SEQ ID NO: 76 (pZR0901 - Ec_frc, Of_oxc, Sc_YBR222C, Sc_YEL020C, At_AAE3, Ec_yfdE, Of_oxlT (medium-strength promoter) expression vector):

GGAGAGCTGTATGTGGGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTT CGTTTTA CAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAA GTTT CACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTG GATC ACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATATT AACA ATAATTTATTTTCAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTG TGCA ATCTGGCCCATCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGA ACGT CCCGGCGTTGGTGACGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTT TACT TCACCATGCTTAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCA AAGA GGTAATGGAAAAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGC CATT GATCACATGGGCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGT TCGA TCAAAGGGTTTGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTC AGGC AGCGGGTGGCGCGGCATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGC AGCG TTGGGTGACAGCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCAT CGCG AAAAAACGGGGCGTGGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTT GCCG CGTGAAATTACGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCA GTAT GCTGGATCCTGAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTA TTCA GGAGCAAAACTGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCC GGCA TACAGTACAGCCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAA TACA CTGTCACTATTGATAAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTG CACC GGTTTTAAGTATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGT TGAA GTGGAACAACCGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCC TTTA CGCCGGATATTAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGC TGGG TTATAGCGACGATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTAGCT GATT AGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTGGTAAGCCAATCTAGGGCCTCGTC TGTA GGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTT TTTT TTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAA ATAA TGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGAGCTGTCACCGGATGTGCT TTCC GGTCTGATGAGTCCGTGAGGACGAAACAGCCTCTACAAATAATTTTGTTTAATCCATCAA TTTA AAATTTAAAATAATGGTTTTTACTCTGGAAGATTTTGTTGGCGATTGGCGTCAGACCGCG GGTT ATAATTTGGATCAAGTCCTGGAACAGGGTGGCGTAAGCTCTCTGTTCCAGAACCTGGGTG TGAG CGTGACGCCGATTCAGCGCATCGTTCTGTCCGGCGAGAACGGTCTGAAAATTGATATTCA TGTG ATCATCCCGTACGAAGGCCTGAGCGGTGACCAAATGGGTCAAATCGAGAAAATCTTTAAA GTCG TCTACCCAGTTGACGATCACCACTTCAAGGTTATCTTGCATTACGGTACGCTGGTGATTG ATGG TGTGACCCCGAATATGATTGACTATTTCGGCCGTCCGTATGAAGGCATTGCCGTTTTTGA CGGT AAAAAGATCACCGTCACCGGTACCCTGTGGAATGGCAATAAGATTATTGACGAGCGTCTG ATTA ACCCGGACGGCAGCCTGCTGTTCCGCGTGACCATCAACGGTGTCACGGGTTGGCGTCTGT GCGA GCGCATCCTGGCAGGTTCAATGAGTAACGACGACAATGTAGAGTTGACTGATGGCTTTCA TGTT TTGATCGATGCCCTGAAAATGAATGACATCGATACCATGTATGGTGTTGTCGGCATTCCT ATCA CGAACCTGGCTCGTATGTGGCAAGATGACGGTCAGCGTTTTTACAGCTTCCGTCACGAAC AACA CGCAGGTTATGCAGCTTCTATCGCCGGTTACATCGAAGGAAAACCTGGCGTTTGCTTGAC CGTT TCCGCCCCTGGCTTCCTGAACGGCGTGACTTCCCTGGCTCATGCAACCACCAACTGCTTC CCAA TGATCCTGTTGAGCGGTTCCAGTGAACGTGAAATCGTCGATTTGCAACAGGGCGATTACG AAGA AATGGATCAGATGAATGTTGCACGTCCACACTGCAAAGCTTCTTTCCGTATCAACAGCAT CAAA GACATTCCAATCGGTATCGCTCGTGCAGTTCGCACCGCTGTATCCGGACGTCCAGGTGGT GTTT ACGTTGACTTGCCAGCAAAACTGTTCGGTCAGACCATTTCTGTAGAAGAAGCTAACAAAC TGCT CTTCAAACCAATCGATCCAGCTCCGGCACAGATTCCTGCTGAAGATGCTATCGCTCGCGC TGCT GACCTGATCAAGAACGCCAAACGTCCAGTTATCATGCTGGGTAAAGGCGCTGCATACGCA CAAT GCGACGACGAAATCCGCGCACTGGTTGAAGAAACCGGCATCCCATTCCTGCCAATGGGTA TGGC TAAAGGCCTGCTGCCTGACAACCATCCACAATCCGCTGCTGCAACCCGTGCTTTCGCACT GGCA CAGTGTGACGTTTGCGTACTGATCGGCGCTCGTCTGAACTGGCTGATGCAGCACGGTAAA GGCA AAACCTGGGGCGACGAACTGAAGAAATACGTTCAGATCGACATCCAGGCTAACGAAATGG ACAG CAACCAGCCTATCGCTGCACCAGTTGTTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCG CAAA GCACTGAAAGGCGCTCCAAAAGCTGACGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTT GACG GCAACAAAGCCAAACTGGCTGGCAAGATGACTGCCGAAACCCCATCCGGAATGATGAACT ACTC CAATTCCCTGGGCGTTGTTCGTGACTTCATGCTGGCAAATCCGGATATTTCCCTGGTTAA CGAA GGCGCTAATGCACTCGACAACACTCGTATGATTGTTGACATGCTGAAACCACGCAAACGT CTTG ACTCCGGTACCTGGGGTGTTATGGGTATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTG TTAC CGGCAAACCGGTTATCGCTGTTGAAGGCGATAGCGCATTCGGTTTCTCCGGTATGGAACT GGAA ACCATCTGCCGTTACAACCTGCCAGTTACCGTTATCATCATGAACAATGGTGGTATCTAT AAAG GTAACGAAGCAGATCCACAACCAGGCGTTATCTCCTGTACCCGTCTGACCCGTGGTCGTT ACGA CATGATGATGGAAGCATTTGGCGGTAAAGGTTATGTTGCCAATACTCCAGCAGAACTGAA AGCT GCTCTGGAAGAAGCTGTTGCTTCCGGCAAACCATGCCTGATCAACGCGATGATCGATCCA GACG CTGGTGTCGAATCTGGCCGTATCAAGAGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAAT AAGG TTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTGCGTTCCTGGC GTGG TGCTCGCATAGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACA ATTG GGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCA CTTG AACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGGATCAC ACAA CATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATATTAACAAT AATT TATTTTCAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTAGCGTAT CCGA TAATGTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCTATCCCA CATG GTGGGTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCTGTTTTC AGAC AAGATACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCCTCGGTG CTAC TATGGACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTTCAATTT TTAT TTGAATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTACAGAGT TCTG AAATTCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCGATGCGA CCAG GTTTAGGGTAGAGTATGATATATACTCTCCAGAGGACAACTACAAAAGGGTTATTTACCG GTCT TTGAACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCCCGTTCC AGTG ACGTTGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGCCTTTGT TACA TTTGAACATTGTGAGAAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCCCTTGGA CAGA TCTTATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTTTCCACT TTTA GAACTCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGGACCAAT TTGT TAAGTACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCTGAACAT GCCC AAACCAAACCCTTTCCCACACATTAGATTCATCAGATCGTGTTCTTCTGCTTTGGCTCCA GCAA CGTTCCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGATGACCG AAGC ATCACATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTACTGTGGG CCAG CCACAAGGAGTCACCGTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCGGGCAAA GTCG GCGAAGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAAAAGCTA ACAA GGAGAACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTTCGACCC TGAG GGGTTTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAAAAGATT TCAC CCATTGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTGCATTTG GTGT TCCCGACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGGAGAAAA AATG ACCTACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATTCCAACC AAGG TGTACTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAGTTATCG CAGA AACTTTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGGTTCCTAGCTGATTAGAAG GCCA TCCTGACGGATGGCCTTTTTTTTGACTGCCCGACGAACGGACTAATCCTGACGTAGGATA AAAC GAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTT TTGT TTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTC TTAT ATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGGATCACACAACATTTAAAAAATAACATT ATGA AAGCACTCGAAAAGAGATTCAAAGGTAATATTAACAATAATTTATTTTCAATGACCACGA CCGC TACCCAACACTTCGCTCAACTTTTACAAAAATATGGCATCGACACAGTCTTTGGAATTGT GGGC ATCCCTATTGTCCAACTAGCGGATACGATGGTTGCCAACGGTATCAAATTCATTCCATGC AGGA ACGAACAGGCTGCCTCATATGCAGCCTCTGCTTATGGTTATATTAGTGATAAGCCCGGCG TGTT ACTTATTGTCGGGGGCCCCGGTTTAATCCACGCACTGGCTGGTATATACAACTCAATGAG TAAT AGGTGGCCTCTTCTAGTAATTGCAGGGAGTTCTTCTCAAAGTGATATACATAAAGGCGGG TTTC AAGAGTTGGATCAAGTTAGTCTTTTGTCCCCATTTTTGAAGTTTACCGGAAAGTTAACCC CTGA CAATATTGACATGATTACTCAGAAGGCTTTGAATTACTGTATACAAGGCACTGCAGGGGT TTCT TACATAGACGTCCCTGCAGATTTTATTGAGTATGAAAAACCCTTAGAAGGAAACGACCGT ACAG GAAATGAATTACCGATGATATTAACTCCAAACATATGTGGCCCTGATCCGTCGAAGATCA AAAA AGTCGTACAGCTTATTTTGCAACATAAAAATAAAAATATTCTGATTGTTATTGGAAAGGG TGCG GTAAAAAACTCACACGAAATCCGCAGACTAGTAAATACGTTCAATCTACCATTTTTACCC ACCC CAATGGCTAAGGGAATTGTCCCAGACTCTTCTCCACTGAACGTTTCATCTGCAAGATCTC AAGC ATTGAAAATAGCGGATATTGTTCTTGTTCTCGGGGCAAGATTAAACTGGATATTGCATTT TGGT ACTTCACCCAAATGGAACTCAGAATCCATATTCATCCAGTTCGATTCCAATCCCGAAACC TTGG GGGATAACAATGTCTCACCTGGTGCTGACCTTTCCATATGGGGAGATATAGGCTTGAGCG TAAC CGCTTTAGTTGAGGAATTGACTCGCCAAGATTCCTGCTGGAAGTATAGTGGTGTTAAGCA AGAA ATACGAGAGAAAATTCAACTGAATCAAACTCGTCTATTGAGGAAAGAGAAGACTAGAGGG GCAC AATTGAATTACAACCAGGTTTATGGAACATTGAGGCCTCTTATCGATGATTACAGGACAA TACT TGTGACGGAGGGAGCAAATACTATGGATATTGCGCGTATTTCATTCCCTACAGACGCTCC AAGG CGCCGTTTAGACGCAGGGACCAACGCGACTATGGGGATTGGGCTCGGATATGCTCTTGCA TGCA AGGCATCTCATCCGGAACTCGATGTGGTGCTGATTCAGGGTGATTCCGCATTTGGATTCT CTGC CATGGAAATTGAAACGGCAGTAAGGTGTCAGCTGGCATTGGTCATCGTTGTGATGAACAA TAGC GGTATTTACCATGGAGAAAAGGATATAGAGGGTGATTTACCTCCAACGGCACTAAGCAAG AACT GCCGTTACGATCTCGTAGGCAAAGGACTGGGTGCCAATGATTTTTTTGTCAACACAATAA GCGA ACTGAGCAGATGCTTCCAACAAGCCGTGCAGCTTTCTCGGACTAAAAGAGAAACAAGTGT CATC AACGTTATCATTGAGCCTGGCGAACAAAAGCAAATTGCCTTTGCCTGGCAGAATAAACCG CGTT TATAGGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTGCTC TGGG TCTGACGGCCATCAAGGGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCG TTTT ACAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAA AGTT TCACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCT GGAT CACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATAT TAAC AATAATTTATTTTCAATGGATAGCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAA AAAT TCCCCGATCGCCGAGCTCTCTCCGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTC ACGA TCTAATCGAACGCGCCGCTTCACGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGT CGTT GCTCTCACCTTCCCTAACACCGTCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCT AGAG CCACGGCGGCGCCGTTGAACGCAGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCG ATTC AGATTCAAAGCTATTGTTAACCTCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTC AAAG CTGAAAATCTCTCACGTCACCGCTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCC GTTG CGGATTCAGATTCCGTCGTTGACTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTG CTCT CTTCCTCCACACTTCTGGCACTACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAA TCTA GCTTCATCCGTCAAGAACATTAAAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTG ATTG TTCTCCCTCTGTTCCATGTTCATGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTG GTGC TGCTGTAACTCTTCCAGCTGCTGGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAA GAAG TATAACGCTACATGGTATACTGCTGTGCCGACCATTCATCAGATCATATTGGACCGCCAC GCGA GCCACCCTGAAACGGAATATCCTAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGG CTCC GGTGATATTGTCCAGGCTTGAGGAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAAT GACA GAGGCAACACATTTGATGAGCTCAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGG TCTG TTGGGAAACCGGTAGGTCAAGAAATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGC CAAA TAACAAAGGAGAGGTTTGTATAAGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCC AGAA GCCAACAAGGCAGGTTTCGAGTTTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGAT ACCG ATGGGTATTTGCATCTGGTGGGTCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGA TATC TCCAATTGAAGTGGATGCAGTACTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATT CGGT GTTCCTGATGAGAAATATGGGGAAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACT ACTG TAACCGAAGAGGACATTAAAGCGTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAA AGAG AGTGTTCATCACTGATAACCTCCCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGT CGCA CAACATTTCCTTGAGAAGCCCTGAGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATG GCCT TTTTTTTGACTGGGTGTTCCGATACACTCAATTTGTGTAGGATAAAACGAAAGGCTCAGT CGAA AGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTA ATCT ATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTC GAAA GAAACAAAGTAGCCTGGATCACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAA AGAG ATTCAAAGGTAATATTAACAATAATTTATTTTCAATGACAAATAATGAAAGCAAAGGGCC GTTT GAAGGCTTATTAGTTATCGATATGACACATGTCCTTAATGGACCTTTCGGAACTCAACTT CTTT GTAATATGGGCGCAAGGGTAATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACCCGCA CATT TGGTCCCTATGTGGATGGACAGTCACTCTATTACAGTTTTATTAATCATGGCAAAGAGAG TGTG GTTCTTGATTTAAAGAATGATCACGATAAAAGTATATTTATAAATATGCTCAAACAAGCT GATG TATTAGCTGAGAATTTTCGCCCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAAACGC TTCA AGAAATCAACCCGCGCCTCATATATGCTTCATCGTCAGGTTTCGGACATACCGGTCCGCT AAAA GATGCTCCTGCCTACGATACCATCATTCAGGCAATGAGCGGGATAATGATGGAAACAGGA TATC CTGATGCTCCGCCAGTGCGCGTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTCTATT TATT CAGCGGAATAGTGAGTGCACTTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATGTCGA TATA GCGATGTTTGATGCCACGCTGAGTTTTCTGGAGCATGGTCTGATGGCATATATCGCAACT GGGA AGTCACCACAACGTCTGGGAAATCGCCATCCCTACATGGCACCTTTTGATGTTTTCAATA CTCA GGATAAGCCGATTACGATTTGTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCCAGGC ACTG GAGCTTACGGAACTGGTTAATGATCCCCGATTTAGCAGCAATATTTTACGCGTACAAAAC CAGG CTATTCTTAAACAATATATTGAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGGTTAG CCAG AATACATGAAGTTGGTGTACCCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTAAATT GCCA CAAACTCAGGCGAGAAATATGTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAATCCG ATAA AAATCAGCGGCTGCGCGGACCCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAGCATG GGGA ACAAATTCGCCAGGAGTTCTCATCATAAGGTTCCTAGCTGATTAGAAGGCCATCCTGACG GATG GCCTTTTTTTTGACTTAGTTTCAATTTTACATTCCAGGAAGTAGGATAAAACGAAAGGCT CAGT CGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATG GTTA ATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTTCCAG TGTC GAAAGAAACAAAGTAGCCTGGATCACACAACATTTAAAAAATAACATTATGAAAGCACTC GAAA AGAGATTCAAAGGTAATATTAACAATAATTTATTTTAATGAATAATCCACAAACAGGACA ATCA ACAGGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAGCAGTTTTGCTGATGTGTATG ATCT CGGGTGTCCAATATTCCTGGACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTT CTTT GGCTGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGG TGGT GGTTACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTT CTCG CTGGCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTC TGGC CGGTGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCC GGAC AAACGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTC CTGC CACTGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTT TGAT CATGGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGC CAAA AAACAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAA TTCT GGGTTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACA GCGT CCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCA GAAC CTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTAC AAAA CCATGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTG CCTT GGGCGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTA CGCT CTGTTCCCATCGACCAACAGCGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGT TTCT TCTGGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAA CCAA CTTCGGATGGAATACCGCTTTCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCT GGCT ACCTTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAA GAAA AAGCTGTACATTAAGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTT TGAC TGCTATGACTAAACGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGTTTCA TCAG CCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCAGGAT TCCC GTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGGGTGG GCCT ACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACGAACC CTTT GGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATAATGA CCCC GAAGCAGGGTTATGCAGCGGAAAAGTTATATACATTCATGTCCATTTATGTAAAAAATCC TGCT GACCTTGTTTATGTCTTGTCAGTCACCATTTGCAAAACCATATTTGACCCTCAAAGAGGC TGAA TTTGATAAGCAACTTGCTACATACTCATAATAAGGAGCTAAATAGAACACGAATGGGAAA TACT CAAATGCCAAACTAAAGAAGATATTGGCCAAAATAAACGCTATACCGAGAGAGAAACTTG ATTT TTCAACTTCCTAAAACAGTGTTGTTCAAACATTTCTACTTATTTGTACTTACCAGTTGAA CCTA CGTTTCCCTAATAAAATGTCTATGGTAAAAAGTTAAAAAATCCTCCTACTTTTGTTAGAT ATAT TTTTTTGTGTAATTTTGTAATCGTTATGCGGCAGTAATAATATACATATTAATACGAGTT AGGA ATCCTGTAGTTCTCATATGCTACGAGGAGGTATTAAAAGGTGCGTTTCGACAATGCATCT ATTG TAGTATATTATTGCTTAATCCAAATGAATATTATAAATTTAGGAATTCTTGCTCACATTG ATGC AGGAAAAACTTCCGTAACCGAGAATCTGCTGTTTGCCAGTGGAGCAACGGAAAAGTGCGG CTGT GTGGATAATGGTGACACCATAACGGACTCTATGGATATAGAGAAACGTAGAGGAATTACT GTTC GGGCTTCTACGACATCTATTATCTGGAATGGTGTGAAATGCAATATCATTGACACTCCGG GACA CATGGATTTTATTGCGGAAGTGGAGCGGACATTCAAAATGCTTGATGGAGCAGTCCTCAT CTTA TCCGCAAAGGAAGGCATACAAGCGCAGACAAAGTTGCTGTTCAATACTTTACAGAAGCTG CAAA TCCCGACAATTATATTTATCAATAAGATTGACCGAGCCGGTGTGAATTTGGAGCGTTTGT ATCT GGATATAAAAGCAAATCTGTCTCAAGATGTCCTGTTTATGCAAAATGTTGTCGATGGATC GGTT TATCCGGTTTGCTCCCAAACATATATAAAGGAAGAATACAAAGAATTTGTATGCAACCAT GACG ACAATATATTAGAACGATATTTGGCGGATAGCGAAATTTCACCGGCTGATTATTGGAATA CGAT AATCGCTCTTGTGGCAAAAGCCAAAGTCTATCCGGTGCTACATGGATCAGCAATGTTCAA TATC GGTATCAATGAGTTGTTGGACGCCATCACTTCTTTTATACTTCCTCCGGCATCGGTTTCA AACA GACTTTCATCTTATCTTTATAAGATAGAGCATGACCCCAAAGGACATAAAAGAAGTTTTC TAAA AATAATTGACGGAAGTCTGAGACTTCGAGATGTTGTAAGAATCAACGATTCGGAAAAATT CATC AAGATTAAAAATCTAAAAACTATCAATCAGGGCAGAGAGATAAATGTTGATGAAGTGGGC GCCA ATGATATCGCGATTGTAGAGGATATGGATGATTTTCGAATCGGAAATTATTTAGGTGCTG AACC TTGTTTGATTCAAGGATTATCGCATCAGCATCCCGCTCTCAAATCCTCCGTCCGGCCAGA CAGG CCCGAAGAGAGAAGCAAGGTGATATCCGCTCTGAATACATTGTGGATTGAAGATCCGTCT TTGT CCTTTTCCATAAACTCATATAGTGATGAATTGGAAATCTCGTTATATGGTTTAACCCAAA AGGA AATCATACAGACATTGCTGGAAGAACGATTTTCCGTAAAGGTCCATTTTGATGAGATCAA GACT ATATACAAAGAACGACCTGTAAAAAAGGTCAATAAGATTATTCAGATCGAAGTGCCGCCC AACC CTTATTGGGCCACAATAGGGCTGACTCTTGAACCCTTACCGTTAGGGACAGGGTTGCAAA TCGA AAGTGACATCTCCTATGGTTATCTGAACCATTCTTTTCAAAATGCCGTTTTTGAAGGGAT TCGT ATGTCTTGCCAATCCGGGTTACATGGATGGGAAGTGACTGATCTGAAAGTAACTTTTACT CAAG CCGAGTATTATAGCCCGGTAAGTACACCAGCTGATTTCAGACAGCTGACCCCTTATGTCT TTAG GCTGGCCTTGCAACAGTCAGGTGTGGACATTCTCGAACCGATGCTCTATTTTGAGTTGCA GATA CCCCAAGCGGCAAGTTCCAAAGCTATTACAGATTTGCAAAAAATGATGTCTGAGATTGAA GATA TCAGTTGCAATAATGAGTGGTGTCATATTAAAGGGAAAGTTCCATTAAATACAAGTAAAG ACTA TGCATCAGAAGTAAGTTCATACACTAAGGGCTTAGGCATTTTTATGGTTAAGCCATGCGG GTAT CAAATAACAAAAGGCGGTTATTCTGATAATATCCGCATGAACGAAAAAGATAAACTTTTA TTCA TGTTCCAAAAATCAATGTCATCAAAATAACCACGAGTCATTGGTAACTATCTATGAAACT GTTT GATACTTTTATAGTTGATTAAACTTGTTCATGGCATTTGCCTTAATATCATCCGCTATGT CAAT GTAGGGTTTCATAGCTTTGTAGTCGCTGTGTCCCGTCCATTTCATGACCACCTGTGCCGG GATT CCGAGAGCCAGCGCATTGCAGATGAATGTCCTTTTTCCTGCATGGGTACTGAGCAAAGCG TATT TGGGTGTGACTTCATCAATACGTTCATTTCCCTTGTAGTAGGTTTCCCGTACAGGCTCGT TGAT TTCTGCCAGTTCGCCCAGCTCTTTCAGGTAATCGTTCATCTTCTGGTTGCTGATGACGGG CAGA GCCATGTAATTCTCGAAATGGATGTCCTTGTATTTGTCCAGTATGGCTTTGCTGTATTTG TTCA GTTCAATCGTCAGGCTGTCGGCAGTCTTGACTGTGGTTATTTCGATGTGGTCGGACTTCA CATC GCTTCTTTTCAGATTGCGAACATCCGAATACCGCAAACTCGTAAAGCAGCAGAACAGGAA AACA TCACGCACACGTTCCAGGTATTGCTTATCCTTGGGTATCTGGTAGTCTTTCAGCTTGTTC AGTT CATCCCAAGTCAGGAAGATTACTTTTTTCGAGGTGGTTTTCAGTTTCGGTTTGAACGTAT CGTA TGCAATGTTCTGATGATGTCCTTTCTTGAAGCTCCAGCGCAGGAACCATTTGAGGAATCC CATT TGCTTGCCGATGGTGCTGTTTCTCATATCCTTGGTGTCACGCAGGAAGTTGACGTATTCG TTCA ATCCAAACTCGTTGAAATAGTTGAACGTTGCATCCTCCTTGAACTCTTTGAGGTGGTTCC TCAC TGCTGCAAATTTTTCATAGGTGGATGCCGTCCAGTTATTCTGGTTACCGCACTCTTTTAC AAAC TCATCGAACACCTCCCAAAAGCTGACAGGGGCTTCTTCCGGCTGTTCTTCACTGGTATCT TTCA TTCTCATGTTGAAAGCTTCCTTCAACTGTTGGGTCGTTGGCATGACCTCCTGCACCTCAA ATTC CTTGAAAATATTCTGGATTTCGGCATAGTATTTCAGCAAGTCCGTATTGATTTCGGCTGC ACTT TGCTTTAGCTTGTTGGTACATCCGTTCTTTACCCGCTGCTTATCTGCATCCCATTTGGCT ACGT CAATCCGGTAGCCCGTTGTAAACTCGATACGTTGGCTGGCAAAGATGACACGCATACGGA TGGG TACGTTCTCTACGATTGGCACACCGTTCTTTTTCCGGCTCTCCAATGCAAAAATGATGTT GCGC TTGATATTCATAATTGGGTGCGTTTGAAATTCTACACCCAAATATACACCCAATTATTGA GATA GCAAAAGACATTTAGAAACATTTACTTTTACTCTATATTGTAATTTACACTTGATTATCA GTCG TTTGCAGTCTTATGATATTCTGTGAAAGTATAAGTTCGAGAGCCTGTCTCTCCGCAAAAA ACGC TGAAAATCAGCAGATTGCAAAACAAACACCCTGTTTTACACCCAAGAATGTAAAGTCGGG TGTT TTTGTTTTATTTAAGATAATACAACCACTACATAATAAAAGAGTAGCGATATTAAAAGAA TCCG ATGAGAAAAGACTAATATTTATCTATCCATTCAGTTTGATTTCTCAGGACTTTACATCGT CCTG AAAGTATTTGTTGCCAGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGA GCAT CAAATGAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCG TTTC TGTAATGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGG TCTG CGATTCCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGT TATC AAGTGAGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCAT TTCT TTCCAGACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACC AAAC CGTTATTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGAC AATT ACAAACAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTC ACCT GAATCAGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGT AACC ATGCATCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCA GCCA GTTTAGTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAG AAAC AACTCTGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACA TTAT CGCGAGCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGG AGCA AGACGTTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGA CAGT TTTATTGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGAC ACAA CGTGGCTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGCCGCGCAGTTCAA CCTG TTGATAGTACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTAACGTACTA AGCT CTCATGTTTAACGAACTAAACCCTCATGGCTAACGTACTAAGCTCTCATGGCTAACGTAC TAAG CTCTCATGTTTCACGTACTAAGCTCTCATGTTTGAACAATAAAATTAATATAAATCAGCA ACTT AAATAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAAGAATATATAAGGCTTTTAAAG CTTT TAAGGTTTAACGGTTGTGGACAACAAGCCAGGGATGTAACGCACTGAGAAGCCCTTAGAG CCTC TCAAAGCAATTTTGAGTGACACAGGAACACTTAACGGCTGACATGGGGCGGCCGCTCAAG TAG [00233] SEQ ID NO: 77 (pZR1871 -Ec_frc, Of_oxc, Sc_YBR222C, Sc_YEL020C, At_AAE3, Ec_yfdE, Of_oxlT (high-strength promoter) expression vector):

GGAGAGCTGTATGTGGGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTT CGTTTTA CAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAA GTTT CACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTG GATC ACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATATT AACA ATAATTTATTTTCAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTG TGCA ATCTGGCCCATCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGA ACGT CCCGGCGTTGGTGACGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTT TACT TCACCATGCTTAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCA AAGA GGTAATGGAAAAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGC CATT GATCACATGGGCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGT TCGA TCAAAGGGTTTGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTC AGGC AGCGGGTGGCGCGGCATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGC AGCG TTGGGTGACAGCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCAT CGCG AAAAAACGGGGCGTGGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTT GCCG CGTGAAATTACGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCA GTAT CCGAATGGTACATTTGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAG CCTG GCTGGATCCTGAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTA TTCA GGAGCAAAACTGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCC GGCA TACAGTACAGCCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAA TACA CTGTCACTATTGATAAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTG CACC GGTTTTAAGTATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGT TGAA GTGGAACAACCGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCC TTTA CGCCGGATATTAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGC TGGG TTATAGCGACGATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTAGCT GATT AGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTGGTAAGCCAATCTAGGGCCTCGTC TGTA GGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTT TTTT TTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAA ATAA TGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGAGCTGTCACCGGATGTGCT TTCC GGTCTGATGAGTCCGTGAGGACGAAACAGCCTCTACAAATAATTTTGTTTAATCCATCAA TTTA AAATTTAAAATAATGGTTTTTACTCTGGAAGATTTTGTTGGCGATTGGCGTCAGACCGCG GGTT ATAATTTGGATCAAGTCCTGGAACAGGGTGGCGTAAGCTCTCTGTTCCAGAACCTGGGTG TGAG CGTGACGCCGATTCAGCGCATCGTTCTGTCCGGCGAGAACGGTCTGAAAATTGATATTCA TGTG ATCATCCCGTACGAAGGCCTGAGCGGTGACCAAATGGGTCAAATCGAGAAAATCTTTAAA GTCG TCTACCCAGTTGACGATCACCACTTCAAGGTTATCTTGCATTACGGTACGCTGGTGATTG ATGG TGTGACCCCGAATATGATTGACTATTTCGGCCGTCCGTATGAAGGCATTGCCGTTTTTGA CGGT AAAAAGATCACCGTCACCGGTACCCTGTGGAATGGCAATAAGATTATTGACGAGCGTCTG ATTA ACCCGGACGGCAGCCTGCTGTTCCGCGTGACCATCAACGGTGTCACGGGTTGGCGTCTGT GCGA TTGATCGATGCCCTGAAAATGAATGACATCGATACCATGTATGGTGTTGTCGGCATTCCT ATCA CGAACCTGGCTCGTATGTGGCAAGATGACGGTCAGCGTTTTTACAGCTTCCGTCACGAAC AACA CGCAGGTTATGCAGCTTCTATCGCCGGTTACATCGAAGGAAAACCTGGCGTTTGCTTGAC CGTT TCCGCCCCTGGCTTCCTGAACGGCGTGACTTCCCTGGCTCATGCAACCACCAACTGCTTC CCAA TGATCCTGTTGAGCGGTTCCAGTGAACGTGAAATCGTCGATTTGCAACAGGGCGATTACG AAGA AATGGATCAGATGAATGTTGCACGTCCACACTGCAAAGCTTCTTTCCGTATCAACAGCAT CAAA GACATTCCAATCGGTATCGCTCGTGCAGTTCGCACCGCTGTATCCGGACGTCCAGGTGGT GTTT ACGTTGACTTGCCAGCAAAACTGTTCGGTCAGACCATTTCTGTAGAAGAAGCTAACAAAC TGCT CTTCAAACCAATCGATCCAGCTCCGGCACAGATTCCTGCTGAAGATGCTATCGCTCGCGC TGCT GACCTGATCAAGAACGCCAAACGTCCAGTTATCATGCTGGGTAAAGGCGCTGCATACGCA CAAT GCGACGACGAAATCCGCGCACTGGTTGAAGAAACCGGCATCCCATTCCTGCCAATGGGTA TGGC TAAAGGCCTGCTGCCTGACAACCATCCACAATCCGCTGCTGCAACCCGTGCTTTCGCACT GGCA CAGTGTGACGTTTGCGTACTGATCGGCGCTCGTCTGAACTGGCTGATGCAGCACGGTAAA GGCA AAACCTGGGGCGACGAACTGAAGAAATACGTTCAGATCGACATCCAGGCTAACGAAATGG ACAG CAACCAGCCTATCGCTGCACCAGTTGTTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCG CAAA GCACTGAAAGGCGCTCCAAAAGCTGACGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTT GACG GCAACAAAGCCAAACTGGCTGGCAAGATGACTGCCGAAACCCCATCCGGAATGATGAACT ACTC CAATTCCCTGGGCGTTGTTCGTGACTTCATGCTGGCAAATCCGGATATTTCCCTGGTTAA CGAA GGCGCTAATGCACTCGACAACACTCGTATGATTGTTGACATGCTGAAACCACGCAAACGT CTTG ACTCCGGTACCTGGGGTGTTATGGGTATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTG TTAC CGGCAAACCGGTTATCGCTGTTGAAGGCGATAGCGCATTCGGTTTCTCCGGTATGGAACT GGAA ACCATCTGCCGTTACAACCTGCCAGTTACCGTTATCATCATGAACAATGGTGGTATCTAT AAAG GTAACGAAGCAGATCCACAACCAGGCGTTATCTCCTGTACCCGTCTGACCCGTGGTCGTT ACGA CATGATGATGGAAGCATTTGGCGGTAAAGGTTATGTTGCCAATACTCCAGCAGAACTGAA AGCT GCTCTGGAAGAAGCTGTTGCTTCCGGCAAACCATGCCTGATCAACGCGATGATCGATCCA GACG CTGGTGTCGAATCTGGCCGTATCAAGAGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAAT AAGG TTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTGCGTTCCTGGC GTGG TGCTCGCATAGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACA ATTG GGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCA CTTG AACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGGATCAC ACAA CATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATATTAACAAT AATT TATTTTCAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTAGCGTAT CCGA TAATGTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCTATCCCA CATG GTGGGTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCTGTTTTC AGAC AAGATACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCCTCGGTG CTAC TATGGACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTTCAATTT TTAT TTGAATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTACAGAGT TCTG AAATTCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCGATGCGA CCAG GTTTAGGGTAGAGTATGATATATACTCTCCAGAGGACAACTACAAAAGGGTTATTTACCG GTCT TTGAACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCCCGTTCC AGTG ACGTTGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGCCTTTGT TACA TTTGAACATTGTGAGAAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCCCTTGGA CAGA TCTTATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTTTCCACT TTTA GAACTCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGGACCAAT TTGT TAAGTACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCTGAACAT GCCC AAACCAAACCCTTTCCCACACATTAGATTCATCAGATCGTGTTCTTCTGCTTTGGCTCCA GCAA CGTTCCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGATGACCG AAGC ATCACATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTACTGTGGG CCAG CCACAAGGAGTCACCGTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCGGGCAAA GTCG GCGAAGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAAAAGCTA ACAA GGAGAACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTTCGACCC TGAG GGGTTTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAAAAGATT TCAC CCATTGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTGCATTTG GTGT TCCCGACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGGAGAAAA AATG ACCTACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATTCCAACC AAGG TGTACTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAGTTATCG CAGA AACTTTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGGTTCCTAGCTGATTAGAAG GCCA TCCTGACGGATGGCCTTTTTTTTGACTGCCCGACGAACGGACTAATCCTGACGTAGGATA AAAC GAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTT TTGT TTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTC TTAT ATTTGCAGTGTCGAAAGAAACAAAGTAGCCTGGATCACACAACATTTAAAAAATAACATT ATGA AAGCACTCGAAAAGAGATTCAAAGGTAATATTAACAATAATTTATTTTCAATGACCACGA CCGC TACCCAACACTTCGCTCAACTTTTACAAAAATATGGCATCGACACAGTCTTTGGAATTGT GGGC ATCCCTATTGTCCAACTAGCGGATACGATGGTTGCCAACGGTATCAAATTCATTCCATGC AGGA ACGAACAGGCTGCCTCATATGCAGCCTCTGCTTATGGTTATATTAGTGATAAGCCCGGCG TGTT ACTTATTGTCGGGGGCCCCGGTTTAATCCACGCACTGGCTGGTATATACAACTCAATGAG TAAT AGGTGGCCTCTTCTAGTAATTGCAGGGAGTTCTTCTCAAAGTGATATACATAAAGGCGGG TTTC AAGAGTTGGATCAAGTTAGTCTTTTGTCCCCATTTTTGAAGTTTACCGGAAAGTTAACCC CTGA CAATATTGACATGATTACTCAGAAGGCTTTGAATTACTGTATACAAGGCACTGCAGGGGT TTCT TACATAGACGTCCCTGCAGATTTTATTGAGTATGAAAAACCCTTAGAAGGAAACGACCGT ACAG GAAATGAATTACCGATGATATTAACTCCAAACATATGTGGCCCTGATCCGTCGAAGATCA AAAA AGTCGTACAGCTTATTTTGCAACATAAAAATAAAAATATTCTGATTGTTATTGGAAAGGG TGCG GTAAAAAACTCACACGAAATCCGCAGACTAGTAAATACGTTCAATCTACCATTTTTACCC ACCC CAATGGCTAAGGGAATTGTCCCAGACTCTTCTCCACTGAACGTTTCATCTGCAAGATCTC AAGC ATTGAAAATAGCGGATATTGTTCTTGTTCTCGGGGCAAGATTAAACTGGATATTGCATTT TGGT ACTTCACCCAAATGGAACTCAGAATCCATATTCATCCAGTTCGATTCCAATCCCGAAACC TTGG GGGATAACAATGTCTCACCTGGTGCTGACCTTTCCATATGGGGAGATATAGGCTTGAGCG TAAC CGCTTTAGTTGAGGAATTGACTCGCCAAGATTCCTGCTGGAAGTATAGTGGTGTTAAGCA AGAA ATACGAGAGAAAATTCAACTGAATCAAACTCGTCTATTGAGGAAAGAGAAGACTAGAGGG GCAC AATTGAATTACAACCAGGTTTATGGAACATTGAGGCCTCTTATCGATGATTACAGGACAA TACT TGTGACGGAGGGAGCAAATACTATGGATATTGCGCGTATTTCATTCCCTACAGACGCTCC AAGG CGCCGTTTAGACGCAGGGACCAACGCGACTATGGGGATTGGGCTCGGATATGCTCTTGCA TGCA AGGCATCTCATCCGGAACTCGATGTGGTGCTGATTCAGGGTGATTCCGCATTTGGATTCT CTGC CATGGAAATTGAAACGGCAGTAAGGTGTCAGCTGGCATTGGTCATCGTTGTGATGAACAA TAGC GGTATTTACCATGGAGAAAAGGATATAGAGGGTGATTTACCTCCAACGGCACTAAGCAAG AACT GCCGTTACGATCTCGTAGGCAAAGGACTGGGTGCCAATGATTTTTTTGTCAACACAATAA GCGA ACTGAGCAGATGCTTCCAACAAGCCGTGCAGCTTTCTCGGACTAAAAGAGAAACAAGTGT CATC AACGTTATCATTGAGCCTGGCGAACAAAAGCAAATTGCCTTTGCCTGGCAGAATAAACCG CGTT TATAGGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTGCTC TGGG TCTGACGGCCATCAAGGGTAGGATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCG TTTT ACAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAA AGTT TCACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTCGAAAGAAACAAAGTAGCCT GGAT CACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGGTAATAT TAAC AATAATTTATTTTCAATGGATAGCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAA AAAT TCCCCGATCGCCGAGCTCTCTCCGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTC ACGA TCTAATCGAACGCGCCGCTTCACGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGT CGTT GCTCTCACCTTCCCTAACACCGTCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCT AGAG CCACGGCGGCGCCGTTGAACGCAGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCG ATTC AGATTCAAAGCTATTGTTAACCTCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTC AAAG CTGAAAATCTCTCACGTCACCGCTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCC GTTG CGGATTCAGATTCCGTCGTTGACTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTG CTCT CTTCCTCCACACTTCTGGCACTACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAA TCTA GCTTCATCCGTCAAGAACATTAAAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTG ATTG TTCTCCCTCTGTTCCATGTTCATGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTG GTGC TGCTGTAACTCTTCCAGCTGCTGGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAA GAAG TATAACGCTACATGGTATACTGCTGTGCCGACCATTCATCAGATCATATTGGACCGCCAC GCGA GCCACCCTGAAACGGAATATCCTAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGG CTCC GGTGATATTGTCCAGGCTTGAGGAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAAT GACA GAGGCAACACATTTGATGAGCTCAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGG TCTG TTGGGAAACCGGTAGGTCAAGAAATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGC CAAA TAACAAAGGAGAGGTTTGTATAAGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCC AGAA GCCAACAAGGCAGGTTTCGAGTTTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGAT ACCG ATGGGTATTTGCATCTGGTGGGTCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGA TATC TCCAATTGAAGTGGATGCAGTACTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATT CGGT GTTCCTGATGAGAAATATGGGGAAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACT ACTG TAACCGAAGAGGACATTAAAGCGTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAA AGAG AGTGTTCATCACTGATAACCTCCCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGT CGCA CAACATTTCCTTGAGAAGCCCTGAGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATG GCCT TTTTTTTGACTGGGTGTTCCGATACACTCAATTTGTGTAGGATAAAACGAAAGGCTCAGT CGAA AGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATGGTTA ATCT ATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTTGCAGTGTC GAAA GAAACAAAGTAGCCTGGATCACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAA AGAG ATTCAAAGGTAATATTAACAATAATTTATTTTCAATGACAAATAATGAAAGCAAAGGGCC GTTT GAAGGCTTATTAGTTATCGATATGACACATGTCCTTAATGGACCTTTCGGAACTCAACTT CTTT GTAATATGGGCGCAAGGGTAATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACCCGCA CATT TGGTCCCTATGTGGATGGACAGTCACTCTATTACAGTTTTATTAATCATGGCAAAGAGAG TGTG GTTCTTGATTTAAAGAATGATCACGATAAAAGTATATTTATAAATATGCTCAAACAAGCT GATG TATTAGCTGAGAATTTTCGCCCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAAACGC TTCA AGAAATCAACCCGCGCCTCATATATGCTTCATCGTCAGGTTTCGGACATACCGGTCCGCT AAAA GATGCTCCTGCCTACGATACCATCATTCAGGCAATGAGCGGGATAATGATGGAAACAGGA TATC CTGATGCTCCGCCAGTGCGCGTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTCTATT TATT CAGCGGAATAGTGAGTGCACTTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATGTCGA TATA GCGATGTTTGATGCCACGCTGAGTTTTCTGGAGCATGGTCTGATGGCATATATCGCAACT GGGA AGTCACCACAACGTCTGGGAAATCGCCATCCCTACATGGCACCTTTTGATGTTTTCAATA CTCA GGATAAGCCGATTACGATTTGTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCCAGGC ACTG GAGCTTACGGAACTGGTTAATGATCCCCGATTTAGCAGCAATATTTTACGCGTACAAAAC CAGG CTATTCTTAAACAATATATTGAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGGTTAG CCAG AATACATGAAGTTGGTGTACCCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTAAATT GCCA CAAACTCAGGCGAGAAATATGTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAATCCG ATAA AAATCAGCGGCTGCGCGGACCCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAGCATG GGGA ACAAATTCGCCAGGAGTTCTCATCATAAGGTTCCTAGCTGATTAGAAGGCCATCCTGACG GATG GCCTTTTTTTTGACTTAGTTTCAATTTTACATTCCAGGAAGTAGGATAAAACGAAAGGCT CAGT CGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGCAATG GTTA ATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTTGCAG TGTC GAAAGAAACAAAGTAGCCTGGATCACACAACATTTAAAAAATAACATTATGAAAGCACTC GAAA AGAGATTCAAAGGTAATATTAACAATAATTTATTTTAATGAATAATCCACAAACAGGACA ATCA ACAGGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAGCAGTTTTGCTGATGTGTATG ATCT CGGGTGTCCAATATTCCTGGACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTT CTTT GGCTGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGG TGGT GGTTACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTT CTCG CTGGCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTC TGGC CGGTGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCC GGAC AAACGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTC CTGC CACTGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTT TGAT CATGGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGC CAAA AAACAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAA TTCT GGGTTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACA GCGT CCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCA GAAC CTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTAC AAAA CCATGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTG CCTT GGGCGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTA CGCT CTGTTCCCATCGACCAACAGCGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGT TTCT TCTGGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAA CCAA CTTCGGATGGAATACCGCTTTCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCT GGCT ACCTTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAA GAAA AAGCTGTACATTAAGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTT TGAC TGCTATGACTAAACGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGTTTCA TCAG CCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCAGGAT TCCC GTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGGGTGG GCCT ACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACGAACC CTTT GGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATAATGA CCCC GAAGCAGGGTTATGCAGCGGAAAAGTTATATACATTCATGTCCATTTATGTAAAAAATCC TGCT GACCTTGTTTATGTCTTGTCAGTCACCATTTGCAAAACCATATTTGACCCTCAAAGAGGC TGAA TTTGATAAGCAACTTGCTACATACTCATAATAAGGAGCTAAATAGAACACGAATGGGAAA TACT CAAATGCCAAACTAAAGAAGATATTGGCCAAAATAAACGCTATACCGAGAGAGAAACTTG ATTT TTCAACTTCCTAAAACAGTGTTGTTCAAACATTTCTACTTATTTGTACTTACCAGTTGAA CCTA CGTTTCCCTAATAAAATGTCTATGGTAAAAAGTTAAAAAATCCTCCTACTTTTGTTAGAT ATAT TTTTTTGTGTAATTTTGTAATCGTTATGCGGCAGTAATAATATACATATTAATACGAGTT AGGA ATCCTGTAGTTCTCATATGCTACGAGGAGGTATTAAAAGGTGCGTTTCGACAATGCATCT ATTG TAGTATATTATTGCTTAATCCAAATGAATATTATAAATTTAGGAATTCTTGCTCACATTG ATGC AGGAAAAACTTCCGTAACCGAGAATCTGCTGTTTGCCAGTGGAGCAACGGAAAAGTGCGG CTGT GTGGATAATGGTGACACCATAACGGACTCTATGGATATAGAGAAACGTAGAGGAATTACT GTTC GGGCTTCTACGACATCTATTATCTGGAATGGTGTGAAATGCAATATCATTGACACTCCGG GACA CATGGATTTTATTGCGGAAGTGGAGCGGACATTCAAAATGCTTGATGGAGCAGTCCTCAT CTTA TCCGCAAAGGAAGGCATACAAGCGCAGACAAAGTTGCTGTTCAATACTTTACAGAAGCTG CAAA TCCCGACAATTATATTTATCAATAAGATTGACCGAGCCGGTGTGAATTTGGAGCGTTTGT ATCT GGATATAAAAGCAAATCTGTCTCAAGATGTCCTGTTTATGCAAAATGTTGTCGATGGATC GGTT TATCCGGTTTGCTCCCAAACATATATAAAGGAAGAATACAAAGAATTTGTATGCAACCAT GACG ACAATATATTAGAACGATATTTGGCGGATAGCGAAATTTCACCGGCTGATTATTGGAATA CGAT AATCGCTCTTGTGGCAAAAGCCAAAGTCTATCCGGTGCTACATGGATCAGCAATGTTCAA TATC GGTATCAATGAGTTGTTGGACGCCATCACTTCTTTTATACTTCCTCCGGCATCGGTTTCA AACA GACTTTCATCTTATCTTTATAAGATAGAGCATGACCCCAAAGGACATAAAAGAAGTTTTC TAAA AATAATTGACGGAAGTCTGAGACTTCGAGATGTTGTAAGAATCAACGATTCGGAAAAATT CATC AAGATTAAAAATCTAAAAACTATCAATCAGGGCAGAGAGATAAATGTTGATGAAGTGGGC GCCA ATGATATCGCGATTGTAGAGGATATGGATGATTTTCGAATCGGAAATTATTTAGGTGCTG AACC TTGTTTGATTCAAGGATTATCGCATCAGCATCCCGCTCTCAAATCCTCCGTCCGGCCAGA CAGG CCCGAAGAGAGAAGCAAGGTGATATCCGCTCTGAATACATTGTGGATTGAAGATCCGTCT TTGT CCTTTTCCATAAACTCATATAGTGATGAATTGGAAATCTCGTTATATGGTTTAACCCAAA AGGA AATCATACAGACATTGCTGGAAGAACGATTTTCCGTAAAGGTCCATTTTGATGAGATCAA GACT ATATACAAAGAACGACCTGTAAAAAAGGTCAATAAGATTATTCAGATCGAAGTGCCGCCC AACC CTTATTGGGCCACAATAGGGCTGACTCTTGAACCCTTACCGTTAGGGACAGGGTTGCAAA TCGA AAGTGACATCTCCTATGGTTATCTGAACCATTCTTTTCAAAATGCCGTTTTTGAAGGGAT TCGT ATGTCTTGCCAATCCGGGTTACATGGATGGGAAGTGACTGATCTGAAAGTAACTTTTACT CAAG CCGAGTATTATAGCCCGGTAAGTACACCAGCTGATTTCAGACAGCTGACCCCTTATGTCT TTAG GCTGGCCTTGCAACAGTCAGGTGTGGACATTCTCGAACCGATGCTCTATTTTGAGTTGCA GATA CCCCAAGCGGCAAGTTCCAAAGCTATTACAGATTTGCAAAAAATGATGTCTGAGATTGAA GATA TCAGTTGCAATAATGAGTGGTGTCATATTAAAGGGAAAGTTCCATTAAATACAAGTAAAG ACTA TGCATCAGAAGTAAGTTCATACACTAAGGGCTTAGGCATTTTTATGGTTAAGCCATGCGG GTAT CAAATAACAAAAGGCGGTTATTCTGATAATATCCGCATGAACGAAAAAGATAAACTTTTA TTCA TGTTCCAAAAATCAATGTCATCAAAATAACCACGAGTCATTGGTAACTATCTATGAAACT GTTT GATACTTTTATAGTTGATTAAACTTGTTCATGGCATTTGCCTTAATATCATCCGCTATGT CAAT GTAGGGTTTCATAGCTTTGTAGTCGCTGTGTCCCGTCCATTTCATGACCACCTGTGCCGG GATT CCGAGAGCCAGCGCATTGCAGATGAATGTCCTTTTTCCTGCATGGGTACTGAGCAAAGCG TATT TGGGTGTGACTTCATCAATACGTTCATTTCCCTTGTAGTAGGTTTCCCGTACAGGCTCGT TGAT TTCTGCCAGTTCGCCCAGCTCTTTCAGGTAATCGTTCATCTTCTGGTTGCTGATGACGGG CAGA GCCATGTAATTCTCGAAATGGATGTCCTTGTATTTGTCCAGTATGGCTTTGCTGTATTTG TTCA GTTCAATCGTCAGGCTGTCGGCAGTCTTGACTGTGGTTATTTCGATGTGGTCGGACTTCA CATC GCTTCTTTTCAGATTGCGAACATCCGAATACCGCAAACTCGTAAAGCAGCAGAACAGGAA AACA TCACGCACACGTTCCAGGTATTGCTTATCCTTGGGTATCTGGTAGTCTTTCAGCTTGTTC AGTT CATCCCAAGTCAGGAAGATTACTTTTTTCGAGGTGGTTTTCAGTTTCGGTTTGAACGTAT CGTA TGCAATGTTCTGATGATGTCCTTTCTTGAAGCTCCAGCGCAGGAACCATTTGAGGAATCC CATT TGCTTGCCGATGGTGCTGTTTCTCATATCCTTGGTGTCACGCAGGAAGTTGACGTATTCG TTCA ATCCAAACTCGTTGAAATAGTTGAACGTTGCATCCTCCTTGAACTCTTTGAGGTGGTTCC TCAC TGCTGCAAATTTTTCATAGGTGGATGCCGTCCAGTTATTCTGGTTACCGCACTCTTTTAC AAAC TCATCGAACACCTCCCAAAAGCTGACAGGGGCTTCTTCCGGCTGTTCTTCACTGGTATCT TTCA TTCTCATGTTGAAAGCTTCCTTCAACTGTTGGGTCGTTGGCATGACCTCCTGCACCTCAA ATTC CTTGAAAATATTCTGGATTTCGGCATAGTATTTCAGCAAGTCCGTATTGATTTCGGCTGC ACTT TGCTTTAGCTTGTTGGTACATCCGTTCTTTACCCGCTGCTTATCTGCATCCCATTTGGCT ACGT CAATCCGGTAGCCCGTTGTAAACTCGATACGTTGGCTGGCAAAGATGACACGCATACGGA TGGG TACGTTCTCTACGATTGGCACACCGTTCTTTTTCCGGCTCTCCAATGCAAAAATGATGTT GCGC TTGATATTCATAATTGGGTGCGTTTGAAATTCTACACCCAAATATACACCCAATTATTGA GATA GCAAAAGACATTTAGAAACATTTACTTTTACTCTATATTGTAATTTACACTTGATTATCA GTCG TTTGCAGTCTTATGATATTCTGTGAAAGTATAAGTTCGAGAGCCTGTCTCTCCGCAAAAA ACGC TGAAAATCAGCAGATTGCAAAACAAACACCCTGTTTTACACCCAAGAATGTAAAGTCGGG TGTT TTTGTTTTATTTAAGATAATACAACCACTACATAATAAAAGAGTAGCGATATTAAAAGAA TCCG ATGAGAAAAGACTAATATTTATCTATCCATTCAGTTTGATTTCTCAGGACTTTACATCGT CCTG AAAGTATTTGTTGCCAGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGA GCAT CAAATGAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCG TTTC TGTAATGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGG TCTG CGATTCCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGT TATC AAGTGAGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCAT TTCT TTCCAGACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACC AAAC CGTTATTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGAC AATT ACAAACAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTC ACCT GAATCAGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGT AACC ATGCATCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCA GCCA GTTTAGTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAG AAAC AACTCTGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACA TTAT CGCGAGCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGG AGCA AGACGTTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGA CAGT TTTATTGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGAC ACAA CGTGGCTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGCCGCGCAGTTCAA CCTG TTGATAGTACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTAACGTACTA AGCT CTCATGTTTAACGAACTAAACCCTCATGGCTAACGTACTAAGCTCTCATGGCTAACGTAC TAAG CTCTCATGTTTCACGTACTAAGCTCTCATGTTTGAACAATAAAATTAATATAAATCAGCA ACTT AAATAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAAGAATATATAAGGCTTTTAAAG CTTT TAAGGTTTAACGGTTGTGGACAACAAGCCAGGGATGTAACGCACTGAGAAGCCCTTAGAG CCTC TCAAAGCAATTTTGAGTGACACAGGAACACTTAACGGCTGACATGGGGCGGCCGCTCAAG TAG [00234] SEQ ID NO: 78 (RBS and N-terminal leader peptide):

GATCACACAACATTTAAAAAATAACATTATGAAAGCACTCGAAAAGAGATTCAAAGG TAATATT AACAATAATTTATTTTCA [00235] SEQ ID NO: 79 (RBS and N-terminal NanoLuc luciferase reporter):

TCCATCAATTTAAAATTTAAAATAATGGTTTTTACTCTGGAAGATTTTGTTGGCGAT TGGCGTC AGACCGCGGGTTATAATTTGGATCAAGTCCTGGAACAGGGTGGCGTAAGCTCTCTGTTCC AGAA CCTGGGTGTGAGCGTGACGCCGATTCAGCGCATCGTTCTGTCCGGCGAGAACGGTCTGAA AATT GATATTCATGTGATCATCCCGTACGAAGGCCTGAGCGGTGACCAAATGGGTCAAATCGAG AAAA TCTTTAAAGTCGTCTACCCAGTTGACGATCACCACTTCAAGGTTATCTTGCATTACGGTA CGCT GGTGATTGATGGTGTGACCCCGAATATGATTGACTATTTCGGCCGTCCGTATGAAGGCAT TGCC GTTTTTGACGGTAAAAAGATCACCGTCACCGGTACCCTGTGGAATGGCAATAAGATTATT GACG AGCGTCTGATTAACCCGGACGGCAGCCTGCTGTTCCGCGTGACCATCAACGGTGTCACGG GTTG GCGTCTGTGCGAGCGCATCCTGGCA [00236] SEQ ID NO: 80 (P_BfP2E5):

GATAAAACGAAAGGCTCAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACC TTTTTTT TGTTTTGTTTGCAATGGTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAA TAAT GTTCTTATATTTCCAGTGTCGAAAGAAACAAAGTAG [00237] SEQ ID NO: 81 (Plasmid encoding oxalate degradation pathway for genomic integration into Bacteroides vulgatus genome):

GGAGAGCTGTATGTGGGGTGGAAGAAGCTATCGTAAAAATGCTGGAGCAGCTTGATC CTCATTC TACCTATTCTGATCCGGAGGAAGTGAAGAGAATGAACGAGCCGTTGCAGGGAAACTTCGA AGGT ATCGGTATACAGTTTAATATGGCGGAGGACACTTTGCTGGTGATACAGCCTGTATCGGGC GGAC CGTCCGAAAAAGTCGGTATTCTGGCCGGTGATCGTATCGTCATGGTGGAAGATACGCTGA TAGC CGGTGTAAAGATGAGTACCGAGGATATTATGCGTCGCCTCCGTGGTCCTAAAGATTCAAA AGTG AATCTGAAAATACTTCGCCGAGGGGTGAAGGAACTGCTCCCCTTTACGGTGAAAAGGGAT AAAA TACCTGTTTACAGCTTGGATGCTTCCTATATGATTAAAGATAAGATCGGTTATATTCGTA TCAA CCGTTTTGCCGCCACTACCCATGAGGAGTTCAAGAAAGCGCTGACCGGGTTGCAGAAGAA AGGA ATGAAAGACTTGATTCTTGATTTGCAGGGCAATGGCGGGGGGTATTTGAATGCTGCTATC GATA TTGCCAATGAATTTTTGGGTAAAAAGGAACTGATTGTCTATACGGAGGGCCGTCGTAATC CTCG TAGCGAGTTTTTTGCCAAAGGTACGGGCGAGTTTCAGAACGGTCGTCTGATGGTATTGGT TGAT GAATTTTCGGCTTCTGCCAGTGAGATTGTGACCGGAGCTGTTCAGGATTGGGACAGAGGC GTTG TGGTAGGCCGTCGCAGTTTTGGTAAAGGCTTGGTGCAGCGTCCCATTGATTTGCCGGACG GTTC GATGATCCGTCTGACGGTGGCCCGCTATTATACGCCTGCCGGACGTTGTATCCAGAAACC TTAC GAGAGCATTGAAAAGTATAATGAAGACCTGATAGACCGTTATAATAAAGGAGAAATGATG AGTG AAGACAGCATCCACTTTCCGGATTCACTGAAGTTCAAGACTCATAGGTTGGCCCGTACGG TATA TGGTGGCGGAGGGATCATGCCCGATTATTTTGTGCCGATTGATACGACTCTCTATACTAA ATAC CATCGTCAGTTGCGTGATAAAGGAGCATTGATGAAAGCTCATTTCCATTTTATTGATGCC CATC GTAAAGAATGGCTGGGCAAATACAAGACTTTCAATGAGTTCTACAAACGTTTTGAAGTGA CTCC GGATATGTTGACACAACTGGTTGCTACCGGCAAGGAGATGGGAGTGGAATATAATGAAGA AGAG TATCAAAAGGCCCTGCCTCTGCTGAGGTTGCAGATGAAAGCATTGATAGCCCGTGATTTA TGGG ATATGAATGAATATTATCACGTCATTAATGACGCGAATGAAAGTATCAGGAAAGCGCTGG AACT GTTGGAGCAACCGGACTTTGAGGGGCTGCTGTTGAAAAAGCGATAGTCAAGACTTTATAT TAAC TGCAGGGGCGCATAGTTGCACTCCTGCAGTTGTCTGAAAAACTTGTAGGATAAAACGAAA GGCT CAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGC AATG GTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTT GCAG TGTCGAAAGAAACAAAGTAGCCTGGCATCTTAATCAATTTTAAACTCACCAAATCAAAAT ATGA AAAAAAAAAATAATAAAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCG GTGT GCAATCTGGCCCATCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAAT TGAA CGTCCCGGCGTTGGTGACGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCG CTTT ACTTCACCATGCTTAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAG GCAA AGAGGTAATGGAAAAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGG GGCC ATTGATCACATGGGCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTT GGTT CGATCAAAGGGTTTGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTG CTCA GGCAGCGGGTGGCGCGGCATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGC TGCA GCGTTGGGTGACAGCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTG CATC CCGCGTGAAATTACGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCC GCAG TATCCGAATGGTACATTTGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGT CAGC CTGGCTGGATCCTGAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCA CTAT TCAGGAGCAAAACTGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGA TCCG GCATACAGTACAGCCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAA AAAT ACACTGTCACTATTGATAAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTT GTGC ACCGGTTTTAAGTATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGT TGTT GAAGTGGAACAACCGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCT GCCT TTACGCCGGATATTAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGG AGCT GGGTTATAGCGACGATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTA ACCT GCCTGGCATCAACTACCTAAATTAATTATCACCCCAAATTAATAACATAAAAATATAATA AAAT GAGTAACGACGACAATGTAGAGTTGACTGATGGCTTTCATGTTTTGATCGATGCCCTGAA AATG AATGACATCGATACCATGTATGGTGTTGTCGGCATTCCTATCACGAACCTGGCTCGTATG TGGC AAGATGACGGTCAGCGTTTTTACAGCTTCCGTCACGAACAACACGCAGGTTATGCAGCTT CTAT CGCCGGTTACATCGAAGGAAAACCTGGCGTTTGCTTGACCGTTTCCGCCCCTGGCTTCCT GAAC GGCGTGACTTCCCTGGCTCATGCAACCACCAACTGCTTCCCAATGATCCTGTTGAGCGGT TCCA GTGAACGTGAAATCGTCGATTTGCAACAGGGCGATTACGAAGAAATGGATCAGATGAATG TTGC ACGTCCACACTGCAAAGCTTCTTTCCGTATCAACAGCATCAAAGACATTCCAATCGGTAT CGCT CGTGCAGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTGTTTACGTTGACTTGCCAGCA AAAC TGTTCGGTCAGACCATTTCTGTAGAAGAAGCTAACAAACTGCTCTTCAAACCAATCGATC CAGC TCCGGCACAGATTCCTGCTGAAGATGCTATCGCTCGCGCTGCTGACCTGATCAAGAACGC CAAA CGTCCAGTTATCATGCTGGGTAAAGGCGCTGCATACGCACAATGCGACGACGAAATCCGC GCAC TGGTTGAAGAAACCGGCATCCCATTCCTGCCAATGGGTATGGCTAAAGGCCTGCTGCCTG ACAA CCATCCACAATCCGCTGCTGCAACCCGTGCTTTCGCACTGGCACAGTGTGACGTTTGCGT ACTG ATCGGCGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAGGCAAAACCTGGGGCGACGAA CTGA AGAAATACGTTCAGATCGACATCCAGGCTAACGAAATGGACAGCAACCAGCCTATCGCTG CACC AGTTGTTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGCAAAGCACTGAAAGGCGCTCC AAAA GCTGACGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTGACGGCAACAAAGCCAAACTG GCTG GCAAGATGACTGCCGAAACCCCATCCGGAATGATGAACTACTCCAATTCCCTGGGCGTTG TTCG TGACTTCATGCTGGCAAATCCGGATATTTCCCTGGTTAACGAAGGCGCTAATGCACTCGA CAAC ACTCGTATGATTGTTGACATGCTGAAACCACGCAAACGTCTTGACTCCGGTACCTGGGGT GTTA TGGGTATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGTTACCGGCAAACCGGTTATCG CTGT TGAAGGCGATAGCGCATTCGGTTTCTCCGGTATGGAACTGGAAACCATCTGCCGTTACAA CCTG CCAGTTACCGTTATCATCATGAACAATGGTGGTATCTATAAAGGTAACGAAGCAGATCCA CAAC CAGGCGTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTACGACATGATGATGGAAGCAT TTGG CGGTAAAGGTTATGTTGCCAATACTCCAGCAGAACTGAAAGCTGCTCTGGAAGAAGCTGT TGCT TCCGGCAAACCATGCCTGATCAACGCGATGATCGATCCAGACGCTGGTGTCGAATCTGGC CGTA TCAAGAGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAATAAGGTTCCTAAACGACCTGGC ATCA CCTAAAAATTATAAATAAATTAATAAACTTTTATTAAAAAAAAATTACAAAATGAATAAT CCAC AAACAGGACAATCAACAGGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAGCAGTTT TGCT GATGTGTATGATCTCGGGTGTCCAATATTCCTGGACACTGTACGCTAACCCGGTTAAAGA CAAC CTTGGCGTTTCTTTGGCTGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATTCAAGCT GGTT CTCAGCCTGGTGGTGGTTACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGATGTTCG GTGG TGCGATGGTTCTCGCTGGCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGCTCTGTA TGCT CTTTATACTCTGGCCGGTGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAACACGGCT AACA GATGGTTCCCGGACAAACGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACGGTCTGG GTGT TCTGCCGTTCCTGCCACTGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGCAGCATT CATG TACACCGGTTTGATCATGGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGTTTCCCT GGCC AGCAAGGCGCCAAAAAACAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCGAAATGC TGAG AACACCACAATTCTGGGTTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGGTTTGCT GCTG GTTGCCAACAGCGTCCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTGACGATC GGTG TTTCGATCCAGAACCTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTTCCGATA AAAT CGGCCGTTACAAAACCATGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGCACTTTT CCCG ACGATTGCTGCCTTGGGCGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTCTTCACA TGGG GTGGTAGCTACGCTCTGTTCCCATCGACCAACAGCGATATTTTCGGTACGGCATACTCTG CCAG AAACTATGGTTTCTTCTGGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGGTCTGGG TGCT GCAATTGCAACCAACTTCGGATGGAATACCGCTTTCCTGATTACTGCGATTACTTCTTTC ATCG CATTTGCTCTGGCTACCTTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAATGGTCA AATT GTCTCCAGAAGAAAAAGCTGTACATTAAGGTTCCTAATTCCCCTGGCATCATCTACCTTT ATTA ATCAACAATCCAAATTATTAATAAAAAAAATTTAAAAAATGACAAATAATGAAAGCAAAG GGCC GTTTGAAGGCTTATTAGTTATCGATATGACACATGTCCTTAATGGACCTTTCGGAACTCA ACTT CTTTGTAATATGGGCGCAAGGGTAATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACC CGCA CATTTGGTCCCTATGTGGATGGACAGTCACTCTATTACAGTTTTATTAATCATGGCAAAG AGAG TGTGGTTCTTGATTTAAAGAATGATCACGATAAAAGTATATTTATAAATATGCTCAAACA AGCT GATGTATTAGCTGAGAATTTTCGCCCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAA ACGC TTCAAGAAATCAACCCGCGCCTCATATATGCTTCATCGTCAGGTTTCGGACATACCGGTC CGCT AAAAGATGCTCCTGCCTACGATACCATCATTCAGGCAATGAGCGGGATAATGATGGAAAC AGGA TATCCTGATGCTCCGCCAGTGCGCGTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTC TATT TATTCAGCGGAATAGTGAGTGCACTTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATG TCGA TATAGCGATGTTTGATGCCACGCTGAGTTTTCTGGAGCATGGTCTGATGGCATATATCGC AACT GGGAAGTCACCACAACGTCTGGGAAATCGCCATCCCTACATGGCACCTTTTGATGTTTTC AATA CTCAGGATAAGCCGATTACGATTTGTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCC AGGC ACTGGAGCTTACGGAACTGGTTAATGATCCCCGATTTAGCAGCAATATTTTACGCGTACA AAAC CAGGCTATTCTTAAACAATATATTGAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGG TTAG CCAGAATACATGAAGTTGGTGTACCCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTA AATT GCCACAAACTCAGGCGAGAAATATGTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAA TCCG ATAAAAATCAGCGGCTGCGCGGACCCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAG CATG GGGAACAAATTCGCCAGGAGTTCTCATCATAAGGTTCCTAAAAACCCTGGCATCATCTAC CTAT ATTAATCATCAACCCAATTTTCATATGTATAAAATTAACAAAATGACAAGTGCCGCTACT GTTA CTGCTTCGTTCAACGATACTTTTAGCGTATCCGATAATGTCGCCGTTATTGTTCCTGAAA CGGA CACTCAGGTGACCTACAGGGATCTATCCCACATGGTGGGTCACTTCCAGACCATGTTCAC AAAT CCTAATTCTCCATTGTACGGAGCTGTTTTCAGACAAGATACAGTGGCGATATCCATGCGT AATG GGCTGGAATTTATCGTCGCTTTCCTCGGTGCTACTATGGACGCTAAAATTGGCGCGCCCT TGAA TCCCAATTATAAGGAAAAGGAGTTCAATTTTTATTTGAATGACCTGAAATCTAAGGCGAT TTGC GTCCCAAAGGGTACCACAAAGTTACAGAGTTCTGAAATTCTAAAATCTGCCTCCACGTTT GGAT GTTTTATCGTAGAGCTGGCCTTCGATGCGACCAGGTTTAGGGTAGAGTATGATATATACT CTCC AGAGGACAACTACAAAAGGGTTATTTACCGGTCTTTGAACAACGCCAAATTTGTCAACAC AAAT CCCGTTAAATTCCCTGGGTTTGCCCGTTCCAGTGACGTTGCCCTGATTTTGCATACCAGT GGTA CCACCTCCACTCCAAAAACGGTGCCTTTGTTACATTTGAACATTGTGAGAAGCACGTTGA ACAT TGCTAACACTTACAAGCTAACGCCCTTGGACAGATCTTATGTCGTGATGCCTCTTTTCCA CGTC CATGGGTTAATTGGTGTTTTACTTTCCACTTTTAGAACTCAGGGTTCTGTTGTGGTTCCC GATG GATTCCATCCAAAGTTATTCTGGGACCAATTTGTTAAGTACAACTGTAATTGGTTCAGTT GCGT TCCCACAATAAGCATGATTATGCTGAACATGCCCAAACCAAACCCTTTCCCACACATTAG ATTC ATCAGATCGTGTTCTTCTGCTTTGGCTCCAGCAACGTTCCATAAGCTGGAGAAGGAATTC AATG CACCTGTCTTGGAGGCCTATGCGATGACCGAAGCATCACATCAAATGACCTCAAACAATC TGCC TCCAGGAAAGAGAAAGCCTGGTACTGTGGGCCAGCCACAAGGAGTCACCGTCGTCATTCT AGAT GACAATGACAATGTCTTGCCCCCGGGCAAAGTCGGCGAAGTTTCCATCAGAGGCGAAAAC GTCA CTTTGGGGTATGCTAATAATCCAAAAGCTAACAAGGAGAACTTCACCAAGAGAGAGAACT ATTT CAGAACCGGTGACCAAGGTTATTTCGACCCTGAGGGGTTTTTGGTCCTTACAGGCAGAAT CAAA GAGCTTATCAACAGGGGTGGTGAAAAGATTTCACCCATTGAGCTCGACGGCATTATGCTA TCGC ATCCAAAGATCGATGAAGCCGTTGCATTTGGTGTTCCCGACGATATGTACGGCCAAGTAG TTCA AGCCGCCATTGTTTTGAAGAAGGGAGAAAAAATGACCTACGAAGAACTGGTGAACTTCTT AAAG AAGCACCTAGCCTCTTTCAAAATTCCAACCAAGGTGTACTTTGTTGATAAGCTACCAAAA ACCG CTACAGGTAAAATCCAGAGAAGAGTTATCGCAGAAACTTTTGCTAAGAGCAGCAGAAATA AGAG TAAGTTGTAGGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGAC TCTG TTGTGTCTTCTTTTAGGTGTGGAATAATTTTCCAACCATCACTTTATCTGTCTCCCGAAC AGCA CCTTATTCAGCCATCGGTTCACATACACGTTCACGAAAGCACATCCTACTCCGATAGCGG CTCC TGCCACTACATCACTGGGATAGTGCACCCCTTGGTTCATCCGGGCAAACCCTACTCCGCA AGCC CATACGGCTGAAGGGGCGATAACATACCACTTAGGATAAGTGATGGAGAGTGAGGTGGCT AAAG AAAAAGCTGCCGCAGTGTGTCCTGAAGGGAATGACGGACTATCGGCATCCGGTGCTCCGT ATGC ATGAATCTTATCCGGATACTTTACAAAAGGCCGGTCACGACCTATTATATGTTTGGCGGC GTAT GTAATCCCCACTGCTTCAATCACACTGGTTCCTATGTAAATGGCATCTTTCAGCATCGGC TGGT CTTTCTTTATCAATGCATAGAGTCCCATGGCTGTAGGTATTCCTACGGGTAGAATCACTC CGCT AGCGGACAATCCGCGGCTCAGTCCGTGTACATCCCATCGGTTGATGGTTTTCAACGTGTT GATG TCTATATTCTGTGCGCTGAGGCTGAATGTAAAACAGGCTGTCAGTATAAGAAAAATAATC CTTT GGCGTTTCATTTAGTTTGGCATTTGTTCAGTGCAAAGATAGGAAAATAATGTAATTCGCA TTTA CCCTTCCCCGAATTAAAGAATAATTTCCATAATTCCTTGTATTATCGCTAGAATTCCTTT ACTT TTGCATCGTGAATACACAGCTTTTAACAGAATTTTTAGTTCTAACAATTAAATAATTTAA ATTC AATCATTTATGTGGTTAAGTAATTCATCTATTGGAAGGAAAGTGGTGATGAGTGTCACAG GTAT CGCCCTTGTCCTGTTTCTGACGTTTCACATGGCGATGAACCTTGTTGCGCTCTTCTCGGA AGAT GCTTACAACATGATTTGTGAATTCTTGGGAGCTAACTGGTACGCGTTGGTTGCAACTGCC GGGC TGGCTGCTCTGTTTGTAATTCACATCATCTACGCTTTCTGGTTGACCATGCAGAACCGTG CAGC TCGCGGTAGCGAACGTTATGCAGTGAACGTTAAACCTAAAACTGTGGAATGGGCATCTCA GAAC ATGCTTGTCCTGGGTATTGTCGTTATTGCCGGATTGGCTCTTCATTTTGCCAATTTCTGG TACA AAATGCAGTTTGCCGAAATTATCGGTGTTCATGATTTGGGCGCATTCGGTCCTACAGACG GTGC CGCTTACATTCGTGAAACATTCGGATGCCCTGTATTTACAGTGCTTTACCTCATTTGGTT AGCA GCTTTGTGGTTCCACCTGACTCACGGATTCTGGAGTGCTTTGCAGACTTTGGGCTGGAGC AATA AAATCTGGTTCGAGCGTTGGAAGACTATTGGTAACATCTACTCTACTTTGGTAGTTCTTG GTTT TGCAGCAGTAGTCGTTATCTACTTCGCTATGACTGGCGCGCCTGATAGGTGGGCTGCCCT TCCT GGTTGGCTTGGTTTCATCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGG CCAG CCTCGCAGAGCAGGATTCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAG GAAC ACCCGCTCGCGGGTGGGCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACC AAGG AAAGTCTACACGAACCCTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATAC CGAA AAAATCGCTATAATGACCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCG GGGA TTGGTGAACAAAAAGGTGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGAT ATTG AGGTATCATTTTATCGTAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAA ATTT TAGCATTTTGTAAAAAAGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTT GCAT CCCGAAGAGTTTCTCTTAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTT TATG TCGTAAAGAGGGGCTTTGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTA GTTG AAACACATAGAAAGTTGCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTA CGTT CTTTTCTCAAAAAACATAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAA TGAA CAAAGTAAATATAAAAGATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAAT AATG AATTGCATAAGTTTAGATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCAT TTTA CTGCTGGATTGGTAAAGAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTAT GTGA GGTAACTCGTAATAAGCTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACT GAAA TTTACATTTCCTAGCCACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGC ACAA ATATAATTCGAAAAATTGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAAT ATGG TTTTGCTAAAATGTTATTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGT AGAT ATTTCTATATTAGCAAAAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGC ACAT TAATTGTATTAAAAAGAAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAA CTTT TGTAATGAAATGGGTTAACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAA AGCT TTAAAACATGCGAGAATATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTA TTTA ATAGTTATAAAATATTTAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTAC GCGG GTACCGACACCGCGGTGGAGGGGAATTGTGTTACAACCAATTAACCAATTCTGATTAGAA AAAC TCATCGAGCATCAAATGAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTT TGAA AAAGCCGTTTCTGTAATGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGAT CCTG GTATCGGTCTGCGATTCCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTC AAAA ATAAGGTTATCAAGTGAGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAA AGCT TATGCATTTCTTTCCAGACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCAC TCGC ATCAACCAAACCGTTATTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCT GTTA AAAGGACAATTACAAACAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCA ACAA TATTTTCACCTGAATCAGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCG CAGT GGTGAGTAACCATGCATCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCAT AAAT TCCGTCAGCCAGTTTAGTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTG CCAT GTTTCAGAAACAACTCTGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTG ATTG CCCGACATTATCGCGAGCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAA TCGC GGCCTGGAGCAAGACGTTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTT ATGT AAGCAGACAGTTTTATTGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGA GATT TTGAGACACAACGTGGCTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGAG CCTA CGTTCCGAATACGGTCAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCC GCTT CGAATTCTTTTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGAT ATTT CAGGTTTGTGATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTC TATA CCATTTGATTCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCG GTGT GTTTACAGAACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCAC TTGG TTCAGCAAACGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTC TTTG GCAAAGAGCAGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGC GCTT CTACCTGATGGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTC CCGG ACAGATGATGCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGT ATGT GTACGCAATACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCC GGAT GATCTTCGGCAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTT CGGC AATGCTGAATCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGG GTGG CGTGTACCGAGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTG TCCT GACTTTCAAACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCAT TCAG TCTCATGCCGACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTC GTTA ATGGCTCCCTTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAG GCGT GTAAGGCTTCCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTT AGCG GCCCCGTTAAACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGG AAAG CACATCCGGTGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATT ATTT GAAAGTTCAAGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAA AAAA GGTAGCCCAATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTA CAGT CGCTCGGCGATCGAAGGCTTCGGAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTA ATAT GCCGCTTCGAATTCTTTTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTC ACCT GATATTTCAGGTTTGTGATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTT TGCT GTCTATACCATTTGATTCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTAC CCAG CCGGTGTGTTTACAGAACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATT TCCG CACTTGGTTCAGCAAACGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGA ACAT TTCTTTGGCAAAGAGCAGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTAC ATAC AGCGCTTCTACCTGATGGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATAT ACAC GTCCCGGACAGATGATGCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAG AAGA AGTATGTGTACGCAATACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATC GCGT GCCGGATGATCTTCGGCAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCC GGAC CTTCGGCAATGCTGAATCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGG TGAG CGGGTGGCGTGTACCGAGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACA ATCG TTGTCCTGACTTTCAAACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTC AGTT CATTCAGTCTCATGCCGACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCA TTAA GTCGTTAATGGCTCCCTTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGC ATTG GAGGCGTGTAAGGCTTCCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAA TATT TTTAGCGGCCCCGTTAAACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATC AGAC CGGAAAGCACATCCGGTGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAA GAAC ATTATTTGAAAGTTCAAGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAA AACA AAAAAAAGGTAGCCCAATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTT TATC CTAGGATCAGCTGTACGTACTCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCAT GTTT CACGTACTAAGCTCTCATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTC ATGG CTAACGTACTAAGCTCTCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTC TCAT GTTTGAACAATAAAATTAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTT TATA AGAAAAAAAAGAATATATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACA AGCC AGGGATGTAACGCACTGAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGG AACA CTTAACGGCTGACATGGGGCGGCCGCGTAG [00238] SEQ ID NO: 82 (Plasmid encoding oxalate degradation pathway for genomic integration into Bacteroides vulgatus genome):

GGAGAGCTGTATGTGGGGTGGAAGAAGCTATCGTAAAAATGCTGGAGCAGCTTGATC CTCATTC TACCTATTCTGATCCGGAGGAAGTGAAGAGAATGAACGAGCCGTTGCAGGGAAACTTCGA AGGT ATCGGTATACAGTTTAATATGGCGGAGGACACTTTGCTGGTGATACAGCCTGTATCGGGC GGAC CGTCCGAAAAAGTCGGTATTCTGGCCGGTGATCGTATCGTCATGGTGGAAGATACGCTGA TAGC CGGTGTAAAGATGAGTACCGAGGATATTATGCGTCGCCTCCGTGGTCCTAAAGATTCAAA AGTG AATCTGAAAATACTTCGCCGAGGGGTGAAGGAACTGCTCCCCTTTACGGTGAAAAGGGAT AAAA CCGTTTTGCCGCCACTACCCATGAGGAGTTCAAGAAAGCGCTGACCGGGTTGCAGAAGAA AGGA ATGAAAGACTTGATTCTTGATTTGCAGGGCAATGGCGGGGGGTATTTGAATGCTGCTATC GATA TTGCCAATGAATTTTTGGGTAAAAAGGAACTGATTGTCTATACGGAGGGCCGTCGTAATC CTCG TAGCGAGTTTTTTGCCAAAGGTACGGGCGAGTTTCAGAACGGTCGTCTGATGGTATTGGT TGAT GAATTTTCGGCTTCTGCCAGTGAGATTGTGACCGGAGCTGTTCAGGATTGGGACAGAGGC GTTG TGGTAGGCCGTCGCAGTTTTGGTAAAGGCTTGGTGCAGCGTCCCATTGATTTGCCGGACG GTTC GATGATCCGTCTGACGGTGGCCCGCTATTATACGCCTGCCGGACGTTGTATCCAGAAACC TTAC GAGAGCATTGAAAAGTATAATGAAGACCTGATAGACCGTTATAATAAAGGAGAAATGATG AGTG AAGACAGCATCCACTTTCCGGATTCACTGAAGTTCAAGACTCATAGGTTGGCCCGTACGG TATA TGGTGGCGGAGGGATCATGCCCGATTATTTTGTGCCGATTGATACGACTCTCTATACTAA ATAC CATCGTCAGTTGCGTGATAAAGGAGCATTGATGAAAGCTCATTTCCATTTTATTGATGCC CATC GTAAAGAATGGCTGGGCAAATACAAGACTTTCAATGAGTTCTACAAACGTTTTGAAGTGA CTCC GGATATGTTGACACAACTGGTTGCTACCGGCAAGGAGATGGGAGTGGAATATAATGAAGA AGAG TATCAAAAGGCCCTGCCTCTGCTGAGGTTGCAGATGAAAGCATTGATAGCCCGTGATTTA TGGG ATATGAATGAATATTATCACGTCATTAATGACGCGAATGAAAGTATCAGGAAAGCGCTGG AACT GTTGGAGCAACCGGACTTTGAGGGGCTGCTGTTGAAAAAGCGATAGTCAAGACTTTATAT TAAC TGCAGGGGCGCATAGTTGCACTCCTGCAGTTGTCTGAAAAACTTGTAGGATAAAACGAAA GGCT CAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGC AATG GTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTT GCAG TGTCGAAAGAAACAAAGTAGCCTGGCATCTTAATCAATTTTAAACTCACCAAATCAAAAT ATGA AAAAAAAAAATAATAAAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCG GTGT GCAATCTGGCCCATCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAAT TGAA CGTCCCGGCGTTGGTGACGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCG CTTT ACTTCACCATGCTTAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAG GCAA AGAGGTAATGGAAAAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGG GGCC ATTGATCACATGGGCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTT GGTT CGATCAAAGGGTTTGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTG CTCA GGCAGCGGGTGGCGCGGCATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGC TGCA GCGTTGGGTGACAGCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTG CATC GCGAAAAAACGGGGCGTGGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACC TTTG CCGCGTGAAATTACGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCC GCAG TATCCGAATGGTACATTTGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGT CAGC CTGGCTGGATCCTGAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCA CTAT TCAGGAGCAAAACTGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGA TCCG GCATACAGTACAGCCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAA AAAT ACACTGTCACTATTGATAAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTT GTGC ACCGGTTTTAAGTATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGT TGTT GAAGTGGAACAACCGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCT GCCT TTACGCCGGATATTAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGG AGCT GGGTTATAGCGACGATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTA ACCT GCCTGGCATCAACTACCTAAATTAATTATCACCCCAAATTAATAACATAAAAATATAATA AAAT GAGTAACGACGACAATGTAGAGTTGACTGATGGCTTTCATGTTTTGATCGATGCCCTGAA AATG AATGACATCGATACCATGTATGGTGTTGTCGGCATTCCTATCACGAACCTGGCTCGTATG TGGC AAGATGACGGTCAGCGTTTTTACAGCTTCCGTCACGAACAACACGCAGGTTATGCAGCTT CTAT CGCCGGTTACATCGAAGGAAAACCTGGCGTTTGCTTGACCGTTTCCGCCCCTGGCTTCCT GAAC GGCGTGACTTCCCTGGCTCATGCAACCACCAACTGCTTCCCAATGATCCTGTTGAGCGGT TCCA GTGAACGTGAAATCGTCGATTTGCAACAGGGCGATTACGAAGAAATGGATCAGATGAATG TTGC ACGTCCACACTGCAAAGCTTCTTTCCGTATCAACAGCATCAAAGACATTCCAATCGGTAT CGCT CGTGCAGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTGTTTACGTTGACTTGCCAGCA AAAC TGTTCGGTCAGACCATTTCTGTAGAAGAAGCTAACAAACTGCTCTTCAAACCAATCGATC CAGC TCCGGCACAGATTCCTGCTGAAGATGCTATCGCTCGCGCTGCTGACCTGATCAAGAACGC CAAA CGTCCAGTTATCATGCTGGGTAAAGGCGCTGCATACGCACAATGCGACGACGAAATCCGC GCAC TGGTTGAAGAAACCGGCATCCCATTCCTGCCAATGGGTATGGCTAAAGGCCTGCTGCCTG ACAA CCATCCACAATCCGCTGCTGCAACCCGTGCTTTCGCACTGGCACAGTGTGACGTTTGCGT ACTG ATCGGCGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAGGCAAAACCTGGGGCGACGAA CTGA AGAAATACGTTCAGATCGACATCCAGGCTAACGAAATGGACAGCAACCAGCCTATCGCTG CACC AGTTGTTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGCAAAGCACTGAAAGGCGCTCC AAAA GCTGACGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTGACGGCAACAAAGCCAAACTG GCTG GCAAGATGACTGCCGAAACCCCATCCGGAATGATGAACTACTCCAATTCCCTGGGCGTTG TTCG TGACTTCATGCTGGCAAATCCGGATATTTCCCTGGTTAACGAAGGCGCTAATGCACTCGA CAAC ACTCGTATGATTGTTGACATGCTGAAACCACGCAAACGTCTTGACTCCGGTACCTGGGGT GTTA TGGGTATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGTTACCGGCAAACCGGTTATCG CTGT TGAAGGCGATAGCGCATTCGGTTTCTCCGGTATGGAACTGGAAACCATCTGCCGTTACAA CCTG CCAGTTACCGTTATCATCATGAACAATGGTGGTATCTATAAAGGTAACGAAGCAGATCCA CAAC CAGGCGTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTACGACATGATGATGGAAGCAT TTGG CGGTAAAGGTTATGTTGCCAATACTCCAGCAGAACTGAAAGCTGCTCTGGAAGAAGCTGT TGCT TCCGGCAAACCATGCCTGATCAACGCGATGATCGATCCAGACGCTGGTGTCGAATCTGGC CGTA TCAAGAGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAATAAGGTTCCTAAACGACCTGGC ATCA CCTAAAAATTATAAATAAATTAATAAACTTTTATTAAAAAAAAATTACAAAATGAATAAT CCAC AAACAGGACAATCAACAGGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAGCAGTTT TGCT GATGTGTATGATCTCGGGTGTCCAATATTCCTGGACACTGTACGCTAACCCGGTTAAAGA CAAC CTTGGCGTTTCTTTGGCTGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATTCAAGCT GGTT CTCAGCCTGGTGGTGGTTACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGATGTTCG GTGG TGCGATGGTTCTCGCTGGCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGCTCTGTA TGCT CTTTATACTCTGGCCGGTGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAACACGGCT AACA GATGGTTCCCGGACAAACGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACGGTCTGG GTGT TCTGCCGTTCCTGCCACTGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGCAGCATT CATG TACACCGGTTTGATCATGGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGTTTCCCT GGCC AGCAAGGCGCCAAAAAACAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCGAAATGC TGAG AACACCACAATTCTGGGTTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGGTTTGCT GCTG GTTGCCAACAGCGTCCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTGACGATC GGTG TTTCGATCCAGAACCTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTTCCGATA AAAT CGGCCGTTACAAAACCATGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGCACTTTT CCCG ACGATTGCTGCCTTGGGCGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTCTTCACA TGGG GTGGTAGCTACGCTCTGTTCCCATCGACCAACAGCGATATTTTCGGTACGGCATACTCTG CCAG AAACTATGGTTTCTTCTGGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGGTCTGGG TGCT GCAATTGCAACCAACTTCGGATGGAATACCGCTTTCCTGATTACTGCGATTACTTCTTTC ATCG CATTTGCTCTGGCTACCTTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAATGGTCA AATT GTCTCCAGAAGAAAAAGCTGTACATTAAGGTTCCTAATTCCCCTGGCATCATCTACCTTT ATTA ATCAACAATCCAAATTATTAATAAAAAAAATTTAAAAAATGACAAATAATGAAAGCAAAG GGCC GTTTGAAGGCTTATTAGTTATCGATATGACACATGTCCTTAATGGACCTTTCGGAACTCA ACTT CTTTGTAATATGGGCGCAAGGGTAATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACC CGCA CATTTGGTCCCTATGTGGATGGACAGTCACTCTATTACAGTTTTATTAATCATGGCAAAG AGAG TGTGGTTCTTGATTTAAAGAATGATCACGATAAAAGTATATTTATAAATATGCTCAAACA AGCT GATGTATTAGCTGAGAATTTTCGCCCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAA ACGC TTCAAGAAATCAACCCGCGCCTCATATATGCTTCATCGTCAGGTTTCGGACATACCGGTC CGCT AAAAGATGCTCCTGCCTACGATACCATCATTCAGGCAATGAGCGGGATAATGATGGAAAC AGGA TATCCTGATGCTCCGCCAGTGCGCGTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTC TATT TATTCAGCGGAATAGTGAGTGCACTTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATG TCGA TATAGCGATGTTTGATGCCACGCTGAGTTTTCTGGAGCATGGTCTGATGGCATATATCGC AACT GGGAAGTCACCACAACGTCTGGGAAATCGCCATCCCTACATGGCACCTTTTGATGTTTTC AATA CTCAGGATAAGCCGATTACGATTTGTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCC AGGC ACTGGAGCTTACGGAACTGGTTAATGATCCCCGATTTAGCAGCAATATTTTACGCGTACA AAAC CAGGCTATTCTTAAACAATATATTGAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGG TTAG CCAGAATACATGAAGTTGGTGTACCCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTA AATT GCCACAAACTCAGGCGAGAAATATGTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAA TCCG ATAAAAATCAGCGGCTGCGCGGACCCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAG CATG GGGAACAAATTCGCCAGGAGTTCTCATCATAAGGTTCCTAAAAACCCTGGCATCATCTAC CTAT ATTAATCATCAACCCAATTTTCATATGTATAAAATTAACAAAATGACAAGTGCCGCTACT GTTA CTGCTTCGTTCAACGATACTTTTAGCGTATCCGATAATGTCGCCGTTATTGTTCCTGAAA CGGA CACTCAGGTGACCTACAGGGATCTATCCCACATGGTGGGTCACTTCCAGACCATGTTCAC AAAT CCTAATTCTCCATTGTACGGAGCTGTTTTCAGACAAGATACAGTGGCGATATCCATGCGT AATG GGCTGGAATTTATCGTCGCTTTCCTCGGTGCTACTATGGACGCTAAAATTGGCGCGCCCT TGAA TCCCAATTATAAGGAAAAGGAGTTCAATTTTTATTTGAATGACCTGAAATCTAAGGCGAT TTGC GTCCCAAAGGGTACCACAAAGTTACAGAGTTCTGAAATTCTAAAATCTGCCTCCACGTTT GGAT GTTTTATCGTAGAGCTGGCCTTCGATGCGACCAGGTTTAGGGTAGAGTATGATATATACT CTCC AGAGGACAACTACAAAAGGGTTATTTACCGGTCTTTGAACAACGCCAAATTTGTCAACAC AAAT CCCGTTAAATTCCCTGGGTTTGCCCGTTCCAGTGACGTTGCCCTGATTTTGCATACCAGT GGTA CCACCTCCACTCCAAAAACGGTGCCTTTGTTACATTTGAACATTGTGAGAAGCACGTTGA ACAT TGCTAACACTTACAAGCTAACGCCCTTGGACAGATCTTATGTCGTGATGCCTCTTTTCCA CGTC CATGGGTTAATTGGTGTTTTACTTTCCACTTTTAGAACTCAGGGTTCTGTTGTGGTTCCC GATG GATTCCATCCAAAGTTATTCTGGGACCAATTTGTTAAGTACAACTGTAATTGGTTCAGTT GCGT TCCCACAATAAGCATGATTATGCTGAACATGCCCAAACCAAACCCTTTCCCACACATTAG ATTC ATCAGATCGTGTTCTTCTGCTTTGGCTCCAGCAACGTTCCATAAGCTGGAGAAGGAATTC AATG CACCTGTCTTGGAGGCCTATGCGATGACCGAAGCATCACATCAAATGACCTCAAACAATC TGCC TCCAGGAAAGAGAAAGCCTGGTACTGTGGGCCAGCCACAAGGAGTCACCGTCGTCATTCT AGAT GACAATGACAATGTCTTGCCCCCGGGCAAAGTCGGCGAAGTTTCCATCAGAGGCGAAAAC GTCA CTTTGGGGTATGCTAATAATCCAAAAGCTAACAAGGAGAACTTCACCAAGAGAGAGAACT ATTT CAGAACCGGTGACCAAGGTTATTTCGACCCTGAGGGGTTTTTGGTCCTTACAGGCAGAAT CAAA GAGCTTATCAACAGGGGTGGTGAAAAGATTTCACCCATTGAGCTCGACGGCATTATGCTA TCGC ATCCAAAGATCGATGAAGCCGTTGCATTTGGTGTTCCCGACGATATGTACGGCCAAGTAG TTCA AGCCGCCATTGTTTTGAAGAAGGGAGAAAAAATGACCTACGAAGAACTGGTGAACTTCTT AAAG AAGCACCTAGCCTCTTTCAAAATTCCAACCAAGGTGTACTTTGTTGATAAGCTACCAAAA ACCG CTACAGGTAAAATCCAGAGAAGAGTTATCGCAGAAACTTTTGCTAAGAGCAGCAGAAATA AGAG TAAGTTGTAGGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGAC TCTG TTGTGTCTTCTTTTAGGTGTGGAATAATTTTCCAACCATCACTTTATCTGTCTCCCGAAC AGCA CCTTATTCAGCCATCGGTTCACATACACGTTCACGAAAGCACATCCTACTCCGATAGCGG CTCC TGCCACTACATCACTGGGATAGTGCACCCCTTGGTTCATCCGGGCAAACCCTACTCCGCA AGCC CATACGGCTGAAGGGGCGATAACATACCACTTAGGATAAGTGATGGAGAGTGAGGTGGCT AAAG AAAAAGCTGCCGCAGTGTGTCCTGAAGGGAATGACGGACTATCGGCATCCGGTGCTCCGT ATGC ATGAATCTTATCCGGATACTTTACAAAAGGCCGGTCACGACCTATTATATGTTTGGCGGC GTAT GTAATCCCCACTGCTTCAATCACACTGGTTCCTATGTAAATGGCATCTTTCAGCATCGGC TGGT CTTTCTTTATCAATGCATAGAGTCCCATGGCTGTAGGTATTCCTACGGGTAGAATCACTC CGCT AGCGGACAATCCGCGGCTCAGTCCGTGTACATCCCATCGGTTGATGGTTTTCAACGTGTT GATG TCTATATTCTGTGCGCTGAGGCTGAATGTAAAACAGGCTGTCAGTATAAGAAAAATAATC CTTT GGCGTTTCATTTAGTTTGGCATTTGTTCAGTGCAAAGATAGGAAAATAATGTAATTCGCA TTTA CCCTTCCCCGAATTAAAGAATAATTTCCATAATTCCTTGTATTATCGCTAGAATTCCTTT ACTT TTGCATCGTGAATACACAGCTTTTAACAGAATTTTTAGTTCTAACAATTAAATAATTTAA ATTC AATCATTTATGTGGTTAAGTAATTCATCTATTGGAAGGAAAGTGGTGATGAGTGTCACAG GTAT CGCCCTTGTCCTGTTTCTGACGTTTCACATGGCGATGAACCTTGTTGCGCTCTTCTCGGA AGAT GCTTACAACATGATTTGTGAATTCTTGGGAGCTAACTGGTACGCGTTGGTTGCAACTGCC GGGC TGGCTGCTCTGTTTGTAATTCACATCATCTACGCTTTCTGGTTGACCATGCAGAACCGTG CAGC TCGCGGTAGCGAACGTTATGCAGTGAACGTTAAACCTAAAACTGTGGAATGGGCATCTCA GAAC ATGCTTGTCCTGGGTATTGTCGTTATTGCCGGATTGGCTCTTCATTTTGCCAATTTCTGG TACA AAATGCAGTTTGCCGAAATTATCGGTGTTCATGATTTGGGCGCATTCGGTCCTACAGACG GTGC CGCTTACATTCGTGAAACATTCGGATGCCCTGTATTTACAGTGCTTTACCTCATTTGGTT AGCA GCTTTGTGGTTCCACCTGACTCACGGATTCTGGAGTGCTTTGCAGACTTTGGGCTGGAGC AATA AAATCTGGTTCGAGCGTTGGAAGACTATTGGTAACATCTACTCTACTTTGGTAGTTCTTG GTTT TGCAGCAGTAGTCGTTATCTACTTCGCTATGACTGGCGCGCCTGATAGGTGGGCTGCCCT TCCT GGTTGGCTTGGTTTCATCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGG CCAG CCTCGCAGAGCAGGATTCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAG GAAC ACCCGCTCGCGGGTGGGCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACC AAGG AAAGTCTACACGAACCCTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATAC CGAA AAAATCGCTATAATGACCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCG GGGA TTGGTGAACAAAAAGGTGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGAT ATTG AGGTATCATTTTATCGTAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAA ATTT TAGCATTTTGTAAAAAAGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTT GCAT CCCGAAGAGTTTCTCTTAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTT TATG TCGTAAAGAGGGGCTTTGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTA GTTG AAACACATAGAAAGTTGCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTA CGTT CTTTTCTCAAAAAACATAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAA TGAA CAAAGTAAATATAAAAGATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAAT AATG AATTGCATAAGTTTAGATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCAT TTTA CTGCTGGATTGGTAAAGAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTAT GTGA GGTAACTCGTAATAAGCTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACT GAAA TTTACATTTCCTAGCCACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGC ACAA ATATAATTCGAAAAATTGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAAT ATGG TTTTGCTAAAATGTTATTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGT AGAT ATTTCTATATTAGCAAAAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGC ACAT TAATTGTATTAAAAAGAAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAA CTTT TGTAATGAAATGGGTTAACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAA AGCT TTAAAACATGCGAGAATATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTA TTTA ATAGTTATAAAATATTTAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTAC GCGG GTACCGACACCGCGGTGGAGGGGAATTGTGTTACAACCAATTAACCAATTCTGATTAGAA AAAC TCATCGAGCATCAAATGAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTT TGAA AAAGCCGTTTCTGTAATGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGAT CCTG GTATCGGTCTGCGATTCCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTC AAAA ATAAGGTTATCAAGTGAGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAA AGCT TATGCATTTCTTTCCAGACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCAC TCGC ATCAACCAAACCGTTATTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCT GTTA AAAGGACAATTACAAACAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCA ACAA TATTTTCACCTGAATCAGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCG CAGT GGTGAGTAACCATGCATCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCAT AAAT TCCGTCAGCCAGTTTAGTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTG CCAT GTTTCAGAAACAACTCTGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTG ATTG CCCGACATTATCGCGAGCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAA TCGC GGCCTGGAGCAAGACGTTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTT ATGT AAGCAGACAGTTTTATTGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGA GATT TTGAGACACAACGTGGCTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGAG CCTA CGTTCCGAATACGGTCAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCC GCTT CGAATTCTTTTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGAT ATTT CAGGTTTGTGATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTC TATA CCATTTGATTCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCG GTGT GTTTACAGAACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCAC TTGG TTCAGCAAACGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTC TTTG GCAAAGAGCAGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGC GCTT CTACCTGATGGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTC CCGG ACAGATGATGCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGT ATGT GTACGCAATACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCC GGAT GATCTTCGGCAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTT CGGC AATGCTGAATCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGG GTGG CGTGTACCGAGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTG TCCT GACTTTCAAACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCAT TCAG TCTCATGCCGACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTC GTTA ATGGCTCCCTTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAG GCGT GTAAGGCTTCCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTT AGCG GCCCCGTTAAACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGG AAAG CACATCCGGTGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATT ATTT GAAAGTTCAAGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAA AAAA GGTAGCCCAATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTA CAGT CGCTCGGCGATCGAAGGCTTCGGAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTA ATAT GCCGCTTCGAATTCTTTTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTC ACCT GATATTTCAGGTTTGTGATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTT TGCT GTCTATACCATTTGATTCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTAC CCAG CCGGTGTGTTTACAGAACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATT TCCG CACTTGGTTCAGCAAACGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGA ACAT TTCTTTGGCAAAGAGCAGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTAC ATAC AGCGCTTCTACCTGATGGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATAT ACAC GTCCCGGACAGATGATGCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAG AAGA AGTATGTGTACGCAATACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATC GCGT GCCGGATGATCTTCGGCAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCC GGAC CTTCGGCAATGCTGAATCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGG TGAG CGGGTGGCGTGTACCGAGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACA ATCG TTGTCCTGACTTTCAAACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTC AGTT CATTCAGTCTCATGCCGACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCA TTAA GTCGTTAATGGCTCCCTTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGC ATTG GAGGCGTGTAAGGCTTCCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAA TATT TTTAGCGGCCCCGTTAAACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATC AGAC CGGAAAGCACATCCGGTGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAA GAAC ATTATTTGAAAGTTCAAGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAA AACA AAAAAAAGGTAGCCCAATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTT TATC CTAGGATCAGCTGTACGTACTCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCAT GTTT CACGTACTAAGCTCTCATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTC ATGG CTAACGTACTAAGCTCTCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTC TCAT GTTTGAACAATAAAATTAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTT TATA AGAAAAAAAAGAATATATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACA AGCC AGGGATGTAACGCACTGAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGG AACA CTTAACGGCTGACATGGGGCGGCCGCGTAG [00239] SEQ ID NO: 83 (Plasmid encoding oxalate degradation pathway for genomic integration into Bacteroides vulgatus genome):

GGAGAGCTGTATGTGGGGTGGAAGAAGCTATCGTAAAAATGCTGGAGCAGCTTGATC CTCATTC TACCTATTCTGATCCGGAGGAAGTGAAGAGAATGAACGAGCCGTTGCAGGGAAACTTCGA AGGT ATCGGTATACAGTTTAATATGGCGGAGGACACTTTGCTGGTGATACAGCCTGTATCGGGC GGAC CGTCCGAAAAAGTCGGTATTCTGGCCGGTGATCGTATCGTCATGGTGGAAGATACGCTGA TAGC CGGTGTAAAGATGAGTACCGAGGATATTATGCGTCGCCTCCGTGGTCCTAAAGATTCAAA AGTG AATCTGAAAATACTTCGCCGAGGGGTGAAGGAACTGCTCCCCTTTACGGTGAAAAGGGAT AAAA TACCTGTTTACAGCTTGGATGCTTCCTATATGATTAAAGATAAGATCGGTTATATTCGTA TCAA CCGTTTTGCCGCCACTACCCATGAGGAGTTCAAGAAAGCGCTGACCGGGTTGCAGAAGAA AGGA ATGAAAGACTTGATTCTTGATTTGCAGGGCAATGGCGGGGGGTATTTGAATGCTGCTATC GATA TTGCCAATGAATTTTTGGGTAAAAAGGAACTGATTGTCTATACGGAGGGCCGTCGTAATC CTCG TAGCGAGTTTTTTGCCAAAGGTACGGGCGAGTTTCAGAACGGTCGTCTGATGGTATTGGT TGAT GAATTTTCGGCTTCTGCCAGTGAGATTGTGACCGGAGCTGTTCAGGATTGGGACAGAGGC GTTG TGGTAGGCCGTCGCAGTTTTGGTAAAGGCTTGGTGCAGCGTCCCATTGATTTGCCGGACG GTTC GATGATCCGTCTGACGGTGGCCCGCTATTATACGCCTGCCGGACGTTGTATCCAGAAACC TTAC GAGAGCATTGAAAAGTATAATGAAGACCTGATAGACCGTTATAATAAAGGAGAAATGATG AGTG AAGACAGCATCCACTTTCCGGATTCACTGAAGTTCAAGACTCATAGGTTGGCCCGTACGG TATA TGGTGGCGGAGGGATCATGCCCGATTATTTTGTGCCGATTGATACGACTCTCTATACTAA ATAC CATCGTCAGTTGCGTGATAAAGGAGCATTGATGAAAGCTCATTTCCATTTTATTGATGCC CATC GTAAAGAATGGCTGGGCAAATACAAGACTTTCAATGAGTTCTACAAACGTTTTGAAGTGA CTCC GGATATGTTGACACAACTGGTTGCTACCGGCAAGGAGATGGGAGTGGAATATAATGAAGA AGAG TATCAAAAGGCCCTGCCTCTGCTGAGGTTGCAGATGAAAGCATTGATAGCCCGTGATTTA TGGG ATATGAATGAATATTATCACGTCATTAATGACGCGAATGAAAGTATCAGGAAAGCGCTGG AACT GTTGGAGCAACCGGACTTTGAGGGGCTGCTGTTGAAAAAGCGATAGTCAAGACTTTATAT TAAC CAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGC AATG GTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTT GCAG TGTCGAAAGAAACAAAGTAGCCTGGCATCATCTACCTTCATTATTAAACAAACCAAATTA ATAT CATAAAAAAATAAAAAAATGACTACCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGA AGTA CGGAATTGATACTGTCTTCGGCATAGTAGGTATTCCGATCGTGCAGTTGGCCGACACTAT GGTC GCGAATGGAATTAAGTTTATACCGTGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGC GCCT ACGGCTACATCTCGGACAAACCTGGTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTC ATGC CTTAGCGGGGATCTATAATAGTATGTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATC CAGC AGCCAGTCAGACATCCACAAGGGAGGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGT CCGT TCCTAAAATTCACTGGTAAACTGACGCCGGATAACATCGATATGATAACCCAAAAAGCAC TCAA CTATTGCATTCAGGGAACCGCCGGAGTGAGCTATATCGATGTCCCCGCTGACTTCATCGA ATAC GAGAAGCCGCTTGAGGGCAATGATAGAACTGGTAACGAGCTGCCAATGATCCTGACGCCC AATA TCTGCGGTCCAGACCCCAGTAAAATTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGA ACAA GAACATATTAATAGTGATAGGTAAAGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTT GGTT AACACCTTTAACTTGCCGTTCCTTCCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGC AGCC CTTTAAATGTGAGCAGCGCCCGGAGCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTAT TGGG AGCTCGCCTGAATTGGATCCTTCACTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTAT TTTT ATACAATTTGACAGTAACCCGGAAACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGAT TTAA GTATCTGGGGGGACATCGGACTATCGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGG ACAG TTGTTGGAAATACTCGGGAGTCAAACAGGAGATCAGGGAAAAGATACAGTTAAACCAGAC CAGA TTGCTCCGTAAGGAAAAAACGCGTGGAGCTCAGCTTAACTATAATCAAGTGTACGGCACC CTTC GTCCGTTAATTGACGACTATCGCACGATCTTGGTCACAGAAGGTGCCAACACAATGGACA TCGC TAGAATAAGTTTTCCGACTGATGCACCTCGCAGAAGACTTGATGCTGGTACAAATGCTAC AATG GGTATAGGTTTAGGTTACGCATTAGCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTT TTAA TCCAAGGCGACAGTGCCTTCGGTTTTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCC AATT AGCCCTTGTGATTGTCGTAATGAATAACTCTGGGATATATCACGGTGAGAAAGACATCGA AGGA GATCTGCCCCCGACCGCTTTGTCAAAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTA GGAG CTAACGACTTCTTCGTCAATACCATCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTC AATT GAGCAGAACCAAGCGCGAAACCTCCGTCATTAATGTCATAATCGAACCGGGAGAGCAGAA ACAG ATCGCGTTCGCATGGCAAAACAAGCCTAGACTGTAAGGTTCCTAACCTGCCTGGCATCTT AATC AATTTTAAACTCACCAAATCAAAATATGAAAAAAAAAAATAATAAAATGTCAACTCCACT TCAA GGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGGCCCATCTTGTACTCAAATGCTG GCCT GGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGCGTTGGTGACGTAACGCGTCACC AGCT GCGAGATATTCCTGATATCGATGCGCTTTACTTCACCATGCTTAACAGTAACAAACGTTC TATT GAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAATGGAAAAGCTGATCCGCGAAGCT GATA TCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCACATGGGCTTCACCTGGGAGCATA TTCA AGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAGGGTTTGATGAGTGTTCGCCTTA TGTG AATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGGTGGCGCGGCATCCACTACGGGT TTTT GGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGTGACAGCAACACCGGAATGCATT TGCT GATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAACGGGGCGTGGGCAACGAGTCAC CATG TCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAAATTACGTGACCAGCAGCGTCTA GATA AATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAATGGTACATTTGGTGATGCAGTTC CCCG CGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGATCCTGAAATGTAAAGGCTGGGA AACC GATCCTAACGCCTATATTTATTTCACTATTCAGGAGCAAAACTGGGAAAACACCTGTAAA GCCA TCGGCAAACCAGAATGGATTACCGATCCGGCATACAGTACAGCCCATGCACGACAGCCAC ATAT TTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCACTATTGATAAACATGAAGCGGT GGCC TATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTTAAGTATGAAAGAAATTTCACTT GATC CCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAACAACCGTTGCGTGGAAAATATC TGAC CGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGGATATTAAAGCTGCGCCGCTATT AGGT GAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAGCGACGATGAAATTGCTGCAATG AAGC AAAACCACGCCATCTGAGGTTCCTAAACGACCTGGCATCATCTACCTTTATTAATCAACA ATCC AAATTATTAATAAAAAAAATTTAAAAAATGACAAATAATGAAAGCAAAGGGCCGTTTGAA GGCT TATTAGTTATCGATATGACACATGTCCTTAATGGACCTTTCGGAACTCAACTTCTTTGTA ATAT GGGCGCAAGGGTAATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACCCGCACATTTGG TCCC TATGTGGATGGACAGTCACTCTATTACAGTTTTATTAATCATGGCAAAGAGAGTGTGGTT CTTG ATTTAAAGAATGATCACGATAAAAGTATATTTATAAATATGCTCAAACAAGCTGATGTAT TAGC TGAGAATTTTCGCCCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAAACGCTTCAAGA AATC AACCCGCGCCTCATATATGCTTCATCGTCAGGTTTCGGACATACCGGTCCGCTAAAAGAT GCTC CTGCCTACGATACCATCATTCAGGCAATGAGCGGGATAATGATGGAAACAGGATATCCTG ATGC TCCGCCAGTGCGCGTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTCTATTTATTCAG CGGA ATAGTGAGTGCACTTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATGTCGATATAGCG ATGT TTGATGCCACGCTGAGTTTTCTGGAGCATGGTCTGATGGCATATATCGCAACTGGGAAGT CACC ACAACGTCTGGGAAATCGCCATCCCTACATGGCACCTTTTGATGTTTTCAATACTCAGGA TAAG CCGATTACGATTTGTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCCAGGCACTGGAG CTTA CGGAACTGGTTAATGATCCCCGATTTAGCAGCAATATTTTACGCGTACAAAACCAGGCTA TTCT TAAACAATATATTGAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGGTTAGCCAGAAT ACAT GAAGTTGGTGTACCCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTAAATTGCCACAA ACTC AGGCGAGAAATATGTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAATCCGATAAAAA TCAG CGGCTGCGCGGACCCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAGCATGGGGAACA AATT CGCCAGGAGTTCTCATCATAAGGTTCCTAAGGGTCCTGGCATCAACTACCTACATTAATA ACCA ACCCAAATGCCTAATCAATAAATATTATAAAATGAATAATCCACAAACAGGACAATCAAC AGGC CTCTTGGGCAATCGTTGGTTCTACTTGGTATTAGCAGTTTTGCTGATGTGTATGATCTCG GGTG TCCAATATTCCTGGACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTTCTTTGG CTGC GGTTCAGACGGCTTTCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGGTGGTGG TTAC TTCGTTGATAAATTCGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTTCTCGCT GGCT GGACCTTCATGGGTATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTCTGGCCG GTGC AGGTGTTGGTATCGTTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCCGGACAA ACGC GGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTCCTGCCA CTGA TCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTTTGATCA TGGG TATCCTGATTATCCTGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGCCAAAAA ACAA ATCGTTGTTACCGACAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAATTCTGG GTTC TGTGGACCGCATTCTTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACAGCGTCC CTTA CGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCAGAACCT GTTC AATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTACAAAACC ATGT CCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTGCCTTGG GCGA TGTAGCCTTTATCGCCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTACGCTCT GTTC CCATCGACCAACAGCGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGTTTCTTC TGGG CTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAACCAACT TCGG ATGGAATACCGCTTTCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCTGGCTAC CTTC GTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAAGAAAAA GCTG TACATTAAGGTTCCTAATTCCCCTGGCATCCCCAAAAAATTAATTCATTTTCTCTTTTCA ACAA TTTAAAAAAAATTAAAAAATGAGTAACGACGACAATGTAGAGTTGACTGATGGCTTTCAT GTTT TGATCGATGCCCTGAAAATGAATGACATCGATACCATGTATGGTGTTGTCGGCATTCCTA TCAC GAACCTGGCTCGTATGTGGCAAGATGACGGTCAGCGTTTTTACAGCTTCCGTCACGAACA ACAC GCAGGTTATGCAGCTTCTATCGCCGGTTACATCGAAGGAAAACCTGGCGTTTGCTTGACC GTTT CCGCCCCTGGCTTCCTGAACGGCGTGACTTCCCTGGCTCATGCAACCACCAACTGCTTCC CAAT GATCCTGTTGAGCGGTTCCAGTGAACGTGAAATCGTCGATTTGCAACAGGGCGATTACGA AGAA ATGGATCAGATGAATGTTGCACGTCCACACTGCAAAGCTTCTTTCCGTATCAACAGCATC AAAG ACATTCCAATCGGTATCGCTCGTGCAGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTG TTTA CGTTGACTTGCCAGCAAAACTGTTCGGTCAGACCATTTCTGTAGAAGAAGCTAACAAACT GCTC TTCAAACCAATCGATCCAGCTCCGGCACAGATTCCTGCTGAAGATGCTATCGCTCGCGCT GCTG ACCTGATCAAGAACGCCAAACGTCCAGTTATCATGCTGGGTAAAGGCGCTGCATACGCAC AATG CGACGACGAAATCCGCGCACTGGTTGAAGAAACCGGCATCCCATTCCTGCCAATGGGTAT GGCT AAAGGCCTGCTGCCTGACAACCATCCACAATCCGCTGCTGCAACCCGTGCTTTCGCACTG GCAC AGTGTGACGTTTGCGTACTGATCGGCGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAG GCAA AACCTGGGGCGACGAACTGAAGAAATACGTTCAGATCGACATCCAGGCTAACGAAATGGA CAGC AACCAGCCTATCGCTGCACCAGTTGTTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGC AAAG CACTGAAAGGCGCTCCAAAAGCTGACGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTG ACGG CAACAAAGCCAAACTGGCTGGCAAGATGACTGCCGAAACCCCATCCGGAATGATGAACTA CTCC AATTCCCTGGGCGTTGTTCGTGACTTCATGCTGGCAAATCCGGATATTTCCCTGGTTAAC GAAG GCGCTAATGCACTCGACAACACTCGTATGATTGTTGACATGCTGAAACCACGCAAACGTC TTGA CTCCGGTACCTGGGGTGTTATGGGTATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGT TACC GGCAAACCGGTTATCGCTGTTGAAGGCGATAGCGCATTCGGTTTCTCCGGTATGGAACTG GAAA CCATCTGCCGTTACAACCTGCCAGTTACCGTTATCATCATGAACAATGGTGGTATCTATA AAGG TAACGAAGCAGATCCACAACCAGGCGTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTA CGAC ATGATGATGGAAGCATTTGGCGGTAAAGGTTATGTTGCCAATACTCCAGCAGAACTGAAA GCTG CTCTGGAAGAAGCTGTTGCTTCCGGCAAACCATGCCTGATCAACGCGATGATCGATCCAG ACGC TGGTGTCGAATCTGGCCGTATCAAGAGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAATA AGGT TCCTAAAATGCCTGGCATCTAAACTAAAATACAATAACCAAAAATCATCTATGCGTAAAA AAAA TTATAAAATGGATAGCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCC CGAT CGCCGAGCTCTCTCCGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTA ATCG AACGCGCCGCTTCACGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTC TCAC CTTCCCTAACACCGTCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCAC GGCG GCGCCGTTGAACGCAGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGAT TCAA AGCTATTGTTAACCTCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGA AAAT CTCTCACGTCACCGCTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGA TTCA GATTCCGTCGTTGACTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTC CTCC ACACTTCTGGCACTACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTT CATC CGTCAAGAACATTAAAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCT CCCT CTGTTCCATGTTCATGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCT GTAA CTCTTCCAGCTGCTGGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATA ACGC TACATGGTATACTGCTGTGCCGACCATTCATCAGATCATATTGGACCGCCACGCGAGCCA CCCT GAAACGGAATATCCTAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTG ATAT TGTCCAGGCTTGAGGAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGG CAAC ACATTTGATGAGCTCAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGG GAAA CCGGTAGGTCAAGAAATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAAC AAAG GAGAGGTTTGTATAAGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCA ACAA GGCAGGTTTCGAGTTTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGATACCGATGG GTAT TTGCATCTGGTGGGTCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCA ATTG AAGTGGATGCAGTACTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTC CTGA TGAGAAATATGGGGAAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAAC CGAA GAGGACATTAAAGCGTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTG TTCA TCACTGATAACCTCCCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAAC ATTT CCTTGAGAAGCCCTGAGGTTCCTAAAAACCCTGGCATCTTTTCCATAACAAAAATTAAAC CTCC TCCATATGAAAAATAAAAATTATAAAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCA ACGA TACTTTTAGCGTATCCGATAATGTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGAC CTAC AGGGATCTATCCCACATGGTGGGTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCA TTGT ACGGAGCTGTTTTCAGACAAGATACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTA TCGT CGCTTTCCTCGGTGCTACTATGGACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAA GGAA AAGGAGTTCAATTTTTATTTGAATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGT ACCA CAAAGTTACAGAGTTCTGAAATTCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAG AGCT GGCCTTCGATGCGACCAGGTTTAGGGTAGAGTATGATATATACTCTCCAGAGGACAACTA CAAA AGGGTTATTTACCGGTCTTTGAACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTC CCTG GGTTTGCCCGTTCCAGTGACGTTGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTC CAAA AACGGTGCCTTTGTTACATTTGAACATTGTGAGAAGCACGTTGAACATTGCTAACACTTA CAAG CTAACGCCCTTGGACAGATCTTATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATT GGTG TTTTACTTTCCACTTTTAGAACTCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAA AGTT ATTCTGGGACCAATTTGTTAAGTACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAG CATG ATTATGCTGAACATGCCCAAACCAAACCCTTTCCCACACATTAGATTCATCAGATCGTGT TCTT CTGCTTTGGCTCCAGCAACGTTCCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGG AGGC CTATGCGATGACCGAAGCATCACATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAG AAAG CCTGGTACTGTGGGCCAGCCACAAGGAGTCACCGTCGTCATTCTAGATGACAATGACAAT GTCT TGCCCCCGGGCAAAGTCGGCGAAGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATG CTAA TAATCCAAAAGCTAACAAGGAGAACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGA CCAA GGTTATTTCGACCCTGAGGGGTTTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAAC AGGG GTGGTGAAAAGATTTCACCCATTGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCG ATGA AGCCGTTGCATTTGGTGTTCCCGACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGT TTTG AAGAAGGGAGAAAAAATGACCTACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCC TCTT TCAAAATTCCAACCAAGGTGTACTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAA TCCA GAGAAGAGTTATCGCAGAAACTTTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGG TTCC TAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTCTGTTGTGTCTTCTT TTAG GTGTGGAATAATTTTCCAACCATCACTTTATCTGTCTCCCGAACAGCACCTTATTCAGCC ATCG GTTCACATACACGTTCACGAAAGCACATCCTACTCCGATAGCGGCTCCTGCCACTACATC ACTG GGATAGTGCACCCCTTGGTTCATCCGGGCAAACCCTACTCCGCAAGCCCATACGGCTGAA GGGG CGATAACATACCACTTAGGATAAGTGATGGAGAGTGAGGTGGCTAAAGAAAAAGCTGCCG CAGT GTGTCCTGAAGGGAATGACGGACTATCGGCATCCGGTGCTCCGTATGCATGAATCTTATC CGGA TACTTTACAAAAGGCCGGTCACGACCTATTATATGTTTGGCGGCGTATGTAATCCCCACT GCTT CAATCACACTGGTTCCTATGTAAATGGCATCTTTCAGCATCGGCTGGTCTTTCTTTATCA ATGC ATAGAGTCCCATGGCTGTAGGTATTCCTACGGGTAGAATCACTCCGCTAGCGGACAATCC GCGG CTCAGTCCGTGTACATCCCATCGGTTGATGGTTTTCAACGTGTTGATGTCTATATTCTGT GCGC TGAGGCTGAATGTAAAACAGGCTGTCAGTATAAGAAAAATAATCCTTTGGCGTTTCATTT AGTT TGGCATTTGTTCAGTGCAAAGATAGGAAAATAATGTAATTCGCATTTACCCTTCCCCGAA TTAA AGAATAATTTCCATAATTCCTTGTATTATCGCTAGAATTCCTTTACTTTTGCATCGTGAA TACA CAGCTTTTAACAGAATTTTTAGTTCTAACAATTAAATAATTTAAATTCAATCATTTATGT GGTT AAGTAATTCATCTATTGGAAGGAAAGTGGTGATGAGTGTCACAGGTATCGCCCTTGTCCT GTTT CTGACGTTTCACATGGCGATGAACCTTGTTGCGCTCTTCTCGGAAGATGCTTACAACATG ATTT GTGAATTCTTGGGAGCTAACTGGTACGCGTTGGTTGCAACTGCCGGGCTGGCTGCTCTGT TTGT AATTCACATCATCTACGCTTTCTGGTTGACCATGCAGAACCGTGCAGCTCGCGGTAGCGA ACGT TATGCAGTGAACGTTAAACCTAAAACTGTGGAATGGGCATCTCAGAACATGCTTGTCCTG GGTA TTGTCGTTATTGCCGGATTGGCTCTTCATTTTGCCAATTTCTGGTACAAAATGCAGTTTG CCGA AATTATCGGTGTTCATGATTTGGGCGCATTCGGTCCTACAGACGGTGCCGCTTACATTCG TGAA ACATTCGGATGCCCTGTATTTACAGTGCTTTACCTCATTTGGTTAGCAGCTTTGTGGTTC CACC TGACTCACGGATTCTGGAGTGCTTTGCAGACTTTGGGCTGGAGCAATAAAATCTGGTTCG AGCG TTGGAAGACTATTGGTAACATCTACTCTACTTTGGTAGTTCTTGGTTTTGCAGCAGTAGT CGTT ATCTACTTCGCTATGACTGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGT TTCA TCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCA GGAT TCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGG GTGG GCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACG AACC CTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATA ATGA CCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCGGGGATTGGTGAACAAA AAGG TGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGATATTGAGGTATCATTTT ATCG TAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAAATTTTAGCATTTTGTA AAAA AGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTTGCATCCCGAAGAGTTT CTCT TAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTTTATGTCGTAAAGAGGG GCTT TGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTAGTTGAAACACATAGAA AGTT GCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTACGTTCTTTTCTCAAAA AACA TAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAATGAACAAAGTAAATAT AAAA GATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAATAATGAATTGCATAAGT TTAG ATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCATTTTACTGCTGGATTGG TAAA GAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTATGTGAGGTAACTCGTAA TAAG CTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACTGAAATTTACATTTCCT AGCC ACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGCACAAATATAATTCGAA AAAT TGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAATATGGTTTTGCTAAAAT GTTA TTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGTAGATATTTCTATATTA GCAA AAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGCACATTAATTGTATTAA AAAG AAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAACTTTTGTAATGAAATG GGTT AACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAAAGCTTTAAAACATGCG AGAA TATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTATTTAATAGTTATAAAA TATT TAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTACGCGGGTACCGACACCG CGGT GGAGGGGAATTGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCATC AAAT GAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTTCT GTAA TGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTGC GATT CCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATCA AGTG AGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCTT TCCA GACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAACC GTTA TTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGACAATTA CAAA CAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCTG AATC AGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAACCA TGCA TCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCAG TTTA GTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAACA ACTC TGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTATC GCGA GCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGGAGCAA GACG TTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAGTT TTAT TGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACAAC GTGG CTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGAGCCTACGTTCCGAATAC GGTC AAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAATTCTTTTA GGAA GCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGTTTGTGAT ACGC TCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATTTGATTCA AGTA CGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTACAGAACG GACA TCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAGCAAACGG GAAG TAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAAGAGCAGC AATA CCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACCTGATGGA AGAA ACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGATGATGCG GATA GGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACGCAATACT ACGT CCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCTTCGGCAA AGTT CAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGCTGAATCC CAGA CGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGTACCGAGT TCTA CAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTTTCAAACA TTTC TTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCATGCCGAC TTCT TTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGCTCCCTTC TTAC TTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAGGCTTCCA CCTC TTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCCGTTAAAC AAAA TTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACATCCGGTGA CAGC TCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAGTTCAAGT GAAA CTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAGCCCAATT GTAA AACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTACAGTCGCTCGGCGATC GAAG GCTTCGGAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAAT TCTT TTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGT TTGT GATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATT TGAT TCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTA CAGA ACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAG CAAA CGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAA GAGC AGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACC TGAT GGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGA TGAT GCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACG CAAT ACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCT TCGG CAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGC TGAA TCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGT ACCG AGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTT TCAA ACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCA TGCC GACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGC TCCC TTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAG GCTT CCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCC GTTA AACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACAT CCGG TGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAG TTCA AGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAG CCCA ATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTAGGATCAGCT GTAC GTACTCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCATGTTTCACGTACTAAGC TCTC ATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTCATGGCTAACGTACTAA GCTC TCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTGAACAATA AAAT TAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAAGA ATAT ATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACAAGCCAGGGATGTAACG CACT GAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGGAACACTTAACGGCTGA CATG GGGCGGCCGCGTAG [00240] SEQ ID NO: 84 (Plasmid encoding oxalate degradation pathway for genomic integration into Bacteroides vulgatus genome):

GGAGAGCTGTATGTGGGGTGGAAGAAGCTATCGTAAAAATGCTGGAGCAGCTTGATC CTCATTC TACCTATTCTGATCCGGAGGAAGTGAAGAGAATGAACGAGCCGTTGCAGGGAAACTTCGA AGGT ATCGGTATACAGTTTAATATGGCGGAGGACACTTTGCTGGTGATACAGCCTGTATCGGGC GGAC CGTCCGAAAAAGTCGGTATTCTGGCCGGTGATCGTATCGTCATGGTGGAAGATACGCTGA TAGC CGGTGTAAAGATGAGTACCGAGGATATTATGCGTCGCCTCCGTGGTCCTAAAGATTCAAA AGTG AATCTGAAAATACTTCGCCGAGGGGTGAAGGAACTGCTCCCCTTTACGGTGAAAAGGGAT AAAA TACCTGTTTACAGCTTGGATGCTTCCTATATGATTAAAGATAAGATCGGTTATATTCGTA TCAA CCGTTTTGCCGCCACTACCCATGAGGAGTTCAAGAAAGCGCTGACCGGGTTGCAGAAGAA AGGA ATGAAAGACTTGATTCTTGATTTGCAGGGCAATGGCGGGGGGTATTTGAATGCTGCTATC GATA TTGCCAATGAATTTTTGGGTAAAAAGGAACTGATTGTCTATACGGAGGGCCGTCGTAATC CTCG TAGCGAGTTTTTTGCCAAAGGTACGGGCGAGTTTCAGAACGGTCGTCTGATGGTATTGGT TGAT GAATTTTCGGCTTCTGCCAGTGAGATTGTGACCGGAGCTGTTCAGGATTGGGACAGAGGC GTTG TGGTAGGCCGTCGCAGTTTTGGTAAAGGCTTGGTGCAGCGTCCCATTGATTTGCCGGACG GTTC GATGATCCGTCTGACGGTGGCCCGCTATTATACGCCTGCCGGACGTTGTATCCAGAAACC TTAC GAGAGCATTGAAAAGTATAATGAAGACCTGATAGACCGTTATAATAAAGGAGAAATGATG AGTG AAGACAGCATCCACTTTCCGGATTCACTGAAGTTCAAGACTCATAGGTTGGCCCGTACGG TATA TGGTGGCGGAGGGATCATGCCCGATTATTTTGTGCCGATTGATACGACTCTCTATACTAA ATAC CATCGTCAGTTGCGTGATAAAGGAGCATTGATGAAAGCTCATTTCCATTTTATTGATGCC CATC GTAAAGAATGGCTGGGCAAATACAAGACTTTCAATGAGTTCTACAAACGTTTTGAAGTGA CTCC GGATATGTTGACACAACTGGTTGCTACCGGCAAGGAGATGGGAGTGGAATATAATGAAGA AGAG TATCAAAAGGCCCTGCCTCTGCTGAGGTTGCAGATGAAAGCATTGATAGCCCGTGATTTA TGGG ATATGAATGAATATTATCACGTCATTAATGACGCGAATGAAAGTATCAGGAAAGCGCTGG AACT GTTGGAGCAACCGGACTTTGAGGGGCTGCTGTTGAAAAAGCGATAGTCAAGACTTTATAT TAAC TGCAGGGGCGCATAGTTGCACTCCTGCAGTTGTCTGAAAAACTTGTAGGATAAAACGAAA GGCT CAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGC AATG GTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTT GCAG TGTCGAAAGAAACAAAGTAGCCTGGCATCATCTACCTTCATTATTAAACAAACCAAATTA ATAT CATAAAAAAATAAAAAAATGACTACCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGA AGTA CGGAATTGATACTGTCTTCGGCATAGTAGGTATTCCGATCGTGCAGTTGGCCGACACTAT GGTC GCGAATGGAATTAAGTTTATACCGTGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGC GCCT ACGGCTACATCTCGGACAAACCTGGTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTC ATGC CTTAGCGGGGATCTATAATAGTATGTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATC CAGC AGCCAGTCAGACATCCACAAGGGAGGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGT CCGT CTATTGCATTCAGGGAACCGCCGGAGTGAGCTATATCGATGTCCCCGCTGACTTCATCGA ATAC GAGAAGCCGCTTGAGGGCAATGATAGAACTGGTAACGAGCTGCCAATGATCCTGACGCCC AATA TCTGCGGTCCAGACCCCAGTAAAATTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGA ACAA GAACATATTAATAGTGATAGGTAAAGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTT GGTT AACACCTTTAACTTGCCGTTCCTTCCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGC AGCC CTTTAAATGTGAGCAGCGCCCGGAGCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTAT TGGG AGCTCGCCTGAATTGGATCCTTCACTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTAT TTTT ATACAATTTGACAGTAACCCGGAAACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGAT TTAA GTATCTGGGGGGACATCGGACTATCGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGG ACAG TTGTTGGAAATACTCGGGAGTCAAACAGGAGATCAGGGAAAAGATACAGTTAAACCAGAC CAGA TTGCTCCGTAAGGAAAAAACGCGTGGAGCTCAGCTTAACTATAATCAAGTGTACGGCACC CTTC GTCCGTTAATTGACGACTATCGCACGATCTTGGTCACAGAAGGTGCCAACACAATGGACA TCGC TAGAATAAGTTTTCCGACTGATGCACCTCGCAGAAGACTTGATGCTGGTACAAATGCTAC AATG GGTATAGGTTTAGGTTACGCATTAGCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTT TTAA TCCAAGGCGACAGTGCCTTCGGTTTTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCC AATT AGCCCTTGTGATTGTCGTAATGAATAACTCTGGGATATATCACGGTGAGAAAGACATCGA AGGA GATCTGCCCCCGACCGCTTTGTCAAAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTA GGAG CTAACGACTTCTTCGTCAATACCATCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTC AATT GAGCAGAACCAAGCGCGAAACCTCCGTCATTAATGTCATAATCGAACCGGGAGAGCAGAA ACAG ATCGCGTTCGCATGGCAAAACAAGCCTAGACTGTAAGGTTCCTAACCTGCCTGGCATCTT AATC AATTTTAAACTCACCAAATCAAAATATGAAAAAAAAAAATAATAAAATGTCAACTCCACT TCAA GGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGGCCCATCTTGTACTCAAATGCTG GCCT GGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGCGTTGGTGACGTAACGCGTCACC AGCT GCGAGATATTCCTGATATCGATGCGCTTTACTTCACCATGCTTAACAGTAACAAACGTTC TATT GAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAATGGAAAAGCTGATCCGCGAAGCT GATA TCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCACATGGGCTTCACCTGGGAGCATA TTCA AGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAGGGTTTGATGAGTGTTCGCCTTA TGTG AATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGGTGGCGCGGCATCCACTACGGGT TTTT GGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGTGACAGCAACACCGGAATGCATT TGCT GATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAACGGGGCGTGGGCAACGAGTCAC CATG TCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAAATTACGTGACCAGCAGCGTCTA GATA AATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAATGGTACATTTGGTGATGCAGTTC CCCG CGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGATCCTGAAATGTAAAGGCTGGGA AACC GATCCTAACGCCTATATTTATTTCACTATTCAGGAGCAAAACTGGGAAAACACCTGTAAA GCCA TCGGCAAACCAGAATGGATTACCGATCCGGCATACAGTACAGCCCATGCACGACAGCCAC ATAT TTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCACTATTGATAAACATGAAGCGGT GGCC TATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTTAAGTATGAAAGAAATTTCACTT GATC CCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAACAACCGTTGCGTGGAAAATATC TGAC CGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGGATATTAAAGCTGCGCCGCTATT AGGT GAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAGCGACGATGAAATTGCTGCAATG AAGC AAAACCACGCCATCTGAGGTTCCTAAACGACCTGGCATCATCTACCTTTATTAATCAACA ATCC AAATTATTAATAAAAAAAATTTAAAAAATGACAAATAATGAAAGCAAAGGGCCGTTTGAA GGCT TATTAGTTATCGATATGACACATGTCCTTAATGGACCTTTCGGAACTCAACTTCTTTGTA ATAT GGGCGCAAGGGTAATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACCCGCACATTTGG TCCC TATGTGGATGGACAGTCACTCTATTACAGTTTTATTAATCATGGCAAAGAGAGTGTGGTT CTTG ATTTAAAGAATGATCACGATAAAAGTATATTTATAAATATGCTCAAACAAGCTGATGTAT TAGC TGAGAATTTTCGCCCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAAACGCTTCAAGA AATC AACCCGCGCCTCATATATGCTTCATCGTCAGGTTTCGGACATACCGGTCCGCTAAAAGAT GCTC CTGCCTACGATACCATCATTCAGGCAATGAGCGGGATAATGATGGAAACAGGATATCCTG ATGC TCCGCCAGTGCGCGTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTCTATTTATTCAG CGGA ATAGTGAGTGCACTTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATGTCGATATAGCG ATGT TTGATGCCACGCTGAGTTTTCTGGAGCATGGTCTGATGGCATATATCGCAACTGGGAAGT CACC ACAACGTCTGGGAAATCGCCATCCCTACATGGCACCTTTTGATGTTTTCAATACTCAGGA TAAG CCGATTACGATTTGTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCCAGGCACTGGAG CTTA CGGAACTGGTTAATGATCCCCGATTTAGCAGCAATATTTTACGCGTACAAAACCAGGCTA TTCT TAAACAATATATTGAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGGTTAGCCAGAAT ACAT GAAGTTGGTGTACCCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTAAATTGCCACAA ACTC AGGCGAGAAATATGTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAATCCGATAAAAA TCAG CGGCTGCGCGGACCCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAGCATGGGGAACA AATT CGCCAGGAGTTCTCATCATAAGGTTCCTAAGGGTCCTGGCATCACCTAAAAATTATAAAT AAAT TAATAAACCTTTTAACATAAAAATTAATAAAATGAATAATCCACAAACAGGACAATCAAC AGGC CTCTTGGGCAATCGTTGGTTCTACTTGGTATTAGCAGTTTTGCTGATGTGTATGATCTCG GGTG TCCAATATTCCTGGACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTTCTTTGG CTGC GGTTCAGACGGCTTTCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGGTGGTGG TTAC TTCGTTGATAAATTCGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTTCTCGCT GGCT GGACCTTCATGGGTATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTCTGGCCG GTGC AGGTGTTGGTATCGTTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCCGGACAA ACGC GGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTCCTGCCA CTGA TCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTTTGATCA TGGG TATCCTGATTATCCTGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGCCAAAAA ACAA ATCGTTGTTACCGACAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAATTCTGG GTTC TGTGGACCGCATTCTTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACAGCGTCC CTTA CGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCAGAACCT GTTC AATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTACAAAACC ATGT CCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTGCCTTGG GCGA TGTAGCCTTTATCGCCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTACGCTCT GTTC CCATCGACCAACAGCGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGTTTCTTC TGGG CTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAACCAACT TCGG ATGGAATACCGCTTTCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCTGGCTAC CTTC GTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAAGAAAAA GCTG TACATTAAGGTTCCTAATTCCCCTGGCATCCCCAAAAAATTAATTCATTTTCTCTTTTCA ACAA TTTAAAAAAAATTAAAAAATGAGTAACGACGACAATGTAGAGTTGACTGATGGCTTTCAT GTTT TGATCGATGCCCTGAAAATGAATGACATCGATACCATGTATGGTGTTGTCGGCATTCCTA TCAC GAACCTGGCTCGTATGTGGCAAGATGACGGTCAGCGTTTTTACAGCTTCCGTCACGAACA ACAC GCAGGTTATGCAGCTTCTATCGCCGGTTACATCGAAGGAAAACCTGGCGTTTGCTTGACC GTTT CCGCCCCTGGCTTCCTGAACGGCGTGACTTCCCTGGCTCATGCAACCACCAACTGCTTCC CAAT GATCCTGTTGAGCGGTTCCAGTGAACGTGAAATCGTCGATTTGCAACAGGGCGATTACGA AGAA ATGGATCAGATGAATGTTGCACGTCCACACTGCAAAGCTTCTTTCCGTATCAACAGCATC AAAG ACATTCCAATCGGTATCGCTCGTGCAGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTG TTTA CGTTGACTTGCCAGCAAAACTGTTCGGTCAGACCATTTCTGTAGAAGAAGCTAACAAACT GCTC TTCAAACCAATCGATCCAGCTCCGGCACAGATTCCTGCTGAAGATGCTATCGCTCGCGCT GCTG ACCTGATCAAGAACGCCAAACGTCCAGTTATCATGCTGGGTAAAGGCGCTGCATACGCAC AATG CGACGACGAAATCCGCGCACTGGTTGAAGAAACCGGCATCCCATTCCTGCCAATGGGTAT GGCT AAAGGCCTGCTGCCTGACAACCATCCACAATCCGCTGCTGCAACCCGTGCTTTCGCACTG GCAC AGTGTGACGTTTGCGTACTGATCGGCGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAG GCAA AACCTGGGGCGACGAACTGAAGAAATACGTTCAGATCGACATCCAGGCTAACGAAATGGA CAGC AACCAGCCTATCGCTGCACCAGTTGTTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGC AAAG CACTGAAAGGCGCTCCAAAAGCTGACGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTG ACGG CAACAAAGCCAAACTGGCTGGCAAGATGACTGCCGAAACCCCATCCGGAATGATGAACTA CTCC AATTCCCTGGGCGTTGTTCGTGACTTCATGCTGGCAAATCCGGATATTTCCCTGGTTAAC GAAG GCGCTAATGCACTCGACAACACTCGTATGATTGTTGACATGCTGAAACCACGCAAACGTC TTGA CTCCGGTACCTGGGGTGTTATGGGTATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGT TACC GGCAAACCGGTTATCGCTGTTGAAGGCGATAGCGCATTCGGTTTCTCCGGTATGGAACTG GAAA CCATCTGCCGTTACAACCTGCCAGTTACCGTTATCATCATGAACAATGGTGGTATCTATA AAGG TAACGAAGCAGATCCACAACCAGGCGTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTA CGAC ATGATGATGGAAGCATTTGGCGGTAAAGGTTATGTTGCCAATACTCCAGCAGAACTGAAA GCTG CTCTGGAAGAAGCTGTTGCTTCCGGCAAACCATGCCTGATCAACGCGATGATCGATCCAG ACGC TGGTGTCGAATCTGGCCGTATCAAGAGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAATA AGGT TCCTAAAATGCCTGGCATCTAAACTAAAATACAATAACCAAAAATCATCTATGCGTAAAA AAAA TTATAAAATGGATAGCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCC CGAT CGCCGAGCTCTCTCCGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTA ATCG AACGCGCCGCTTCACGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTC TCAC CTTCCCTAACACCGTCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCAC GGCG GCGCCGTTGAACGCAGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGAT TCAA AGCTATTGTTAACCTCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGA AAAT CTCTCACGTCACCGCTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGA TTCA GATTCCGTCGTTGACTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTC CTCC ACACTTCTGGCACTACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTT CATC CGTCAAGAACATTAAAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCT CCCT CTGTTCCATGTTCATGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCT GTAA CTCTTCCAGCTGCTGGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATA ACGC TACATGGTATACTGCTGTGCCGACCATTCATCAGATCATATTGGACCGCCACGCGAGCCA CCCT GAAACGGAATATCCTAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTG ATAT TGTCCAGGCTTGAGGAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGG CAAC ACATTTGATGAGCTCAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGG GAAA CCGGTAGGTCAAGAAATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAAC AAAG GAGAGGTTTGTATAAGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCA ACAA GGCAGGTTTCGAGTTTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGATACCGATGG GTAT TTGCATCTGGTGGGTCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCA ATTG AAGTGGATGCAGTACTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTC CTGA TGAGAAATATGGGGAAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAAC CGAA GAGGACATTAAAGCGTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTG TTCA TCACTGATAACCTCCCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAAC ATTT CCTTGAGAAGCCCTGAGGTTCCTAAAAACCCTGGCATCTTTTCCATAACAAAAATTAAAC CTCC TCCATATGAAAAATAAAAATTATAAAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCA ACGA TACTTTTAGCGTATCCGATAATGTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGAC CTAC AGGGATCTATCCCACATGGTGGGTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCA TTGT ACGGAGCTGTTTTCAGACAAGATACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTA TCGT CGCTTTCCTCGGTGCTACTATGGACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAA GGAA AAGGAGTTCAATTTTTATTTGAATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGT ACCA CAAAGTTACAGAGTTCTGAAATTCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAG AGCT GGCCTTCGATGCGACCAGGTTTAGGGTAGAGTATGATATATACTCTCCAGAGGACAACTA CAAA AGGGTTATTTACCGGTCTTTGAACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTC CCTG GGTTTGCCCGTTCCAGTGACGTTGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTC CAAA AACGGTGCCTTTGTTACATTTGAACATTGTGAGAAGCACGTTGAACATTGCTAACACTTA CAAG CTAACGCCCTTGGACAGATCTTATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATT GGTG TTTTACTTTCCACTTTTAGAACTCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAA AGTT ATTCTGGGACCAATTTGTTAAGTACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAG CATG ATTATGCTGAACATGCCCAAACCAAACCCTTTCCCACACATTAGATTCATCAGATCGTGT TCTT CTGCTTTGGCTCCAGCAACGTTCCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGG AGGC CTATGCGATGACCGAAGCATCACATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAG AAAG CCTGGTACTGTGGGCCAGCCACAAGGAGTCACCGTCGTCATTCTAGATGACAATGACAAT GTCT TGCCCCCGGGCAAAGTCGGCGAAGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATG CTAA TAATCCAAAAGCTAACAAGGAGAACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGA CCAA GGTTATTTCGACCCTGAGGGGTTTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAAC AGGG GTGGTGAAAAGATTTCACCCATTGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCG ATGA AGCCGTTGCATTTGGTGTTCCCGACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGT TTTG AAGAAGGGAGAAAAAATGACCTACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCC TCTT TCAAAATTCCAACCAAGGTGTACTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAA TCCA GAGAAGAGTTATCGCAGAAACTTTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGG TTCC TAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTCTGTTGTGTCTTCTT TTAG GTGTGGAATAATTTTCCAACCATCACTTTATCTGTCTCCCGAACAGCACCTTATTCAGCC ATCG GTTCACATACACGTTCACGAAAGCACATCCTACTCCGATAGCGGCTCCTGCCACTACATC ACTG GGATAGTGCACCCCTTGGTTCATCCGGGCAAACCCTACTCCGCAAGCCCATACGGCTGAA GGGG CGATAACATACCACTTAGGATAAGTGATGGAGAGTGAGGTGGCTAAAGAAAAAGCTGCCG CAGT GTGTCCTGAAGGGAATGACGGACTATCGGCATCCGGTGCTCCGTATGCATGAATCTTATC CGGA TACTTTACAAAAGGCCGGTCACGACCTATTATATGTTTGGCGGCGTATGTAATCCCCACT GCTT CAATCACACTGGTTCCTATGTAAATGGCATCTTTCAGCATCGGCTGGTCTTTCTTTATCA ATGC ATAGAGTCCCATGGCTGTAGGTATTCCTACGGGTAGAATCACTCCGCTAGCGGACAATCC GCGG CTCAGTCCGTGTACATCCCATCGGTTGATGGTTTTCAACGTGTTGATGTCTATATTCTGT GCGC TGAGGCTGAATGTAAAACAGGCTGTCAGTATAAGAAAAATAATCCTTTGGCGTTTCATTT AGTT TGGCATTTGTTCAGTGCAAAGATAGGAAAATAATGTAATTCGCATTTACCCTTCCCCGAA TTAA AGAATAATTTCCATAATTCCTTGTATTATCGCTAGAATTCCTTTACTTTTGCATCGTGAA TACA CAGCTTTTAACAGAATTTTTAGTTCTAACAATTAAATAATTTAAATTCAATCATTTATGT GGTT AAGTAATTCATCTATTGGAAGGAAAGTGGTGATGAGTGTCACAGGTATCGCCCTTGTCCT GTTT CTGACGTTTCACATGGCGATGAACCTTGTTGCGCTCTTCTCGGAAGATGCTTACAACATG ATTT GTGAATTCTTGGGAGCTAACTGGTACGCGTTGGTTGCAACTGCCGGGCTGGCTGCTCTGT TTGT AATTCACATCATCTACGCTTTCTGGTTGACCATGCAGAACCGTGCAGCTCGCGGTAGCGA ACGT TATGCAGTGAACGTTAAACCTAAAACTGTGGAATGGGCATCTCAGAACATGCTTGTCCTG GGTA TTGTCGTTATTGCCGGATTGGCTCTTCATTTTGCCAATTTCTGGTACAAAATGCAGTTTG CCGA AATTATCGGTGTTCATGATTTGGGCGCATTCGGTCCTACAGACGGTGCCGCTTACATTCG TGAA ACATTCGGATGCCCTGTATTTACAGTGCTTTACCTCATTTGGTTAGCAGCTTTGTGGTTC CACC TGACTCACGGATTCTGGAGTGCTTTGCAGACTTTGGGCTGGAGCAATAAAATCTGGTTCG AGCG TTGGAAGACTATTGGTAACATCTACTCTACTTTGGTAGTTCTTGGTTTTGCAGCAGTAGT CGTT ATCTACTTCGCTATGACTGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGT TTCA TCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCA GGAT TCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGG GTGG GCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACG AACC CTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATA ATGA CCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCGGGGATTGGTGAACAAA AAGG TGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGATATTGAGGTATCATTTT ATCG TAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAAATTTTAGCATTTTGTA AAAA AGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTTGCATCCCGAAGAGTTT CTCT TAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTTTATGTCGTAAAGAGGG GCTT TGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTAGTTGAAACACATAGAA AGTT GCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTACGTTCTTTTCTCAAAA AACA TAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAATGAACAAAGTAAATAT AAAA GATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAATAATGAATTGCATAAGT TTAG ATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCATTTTACTGCTGGATTGG TAAA GAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTATGTGAGGTAACTCGTAA TAAG CTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACTGAAATTTACATTTCCT AGCC ACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGCACAAATATAATTCGAA AAAT TGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAATATGGTTTTGCTAAAAT GTTA TTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGTAGATATTTCTATATTA GCAA AAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGCACATTAATTGTATTAA AAAG AAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAACTTTTGTAATGAAATG GGTT AACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAAAGCTTTAAAACATGCG AGAA TATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTATTTAATAGTTATAAAA TATT TAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTACGCGGGTACCGACACCG CGGT GGAGGGGAATTGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCATC AAAT GAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTTCT GTAA TGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTGC GATT CCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATCA AGTG AGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCTT TCCA GACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAACC GTTA TTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGACAATTA CAAA CAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCTG AATC AGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAACCA TGCA TCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCAG TTTA GTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAACA ACTC TGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTATC GCGA GCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGGAGCAA GACG TTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAGTT TTAT TGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACAAC GTGG CTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGAGCCTACGTTCCGAATAC GGTC AAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAATTCTTTTA GGAA GCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGTTTGTGAT ACGC TCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATTTGATTCA AGTA CGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTACAGAACG GACA TCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAGCAAACGG GAAG TAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAAGAGCAGC AATA CCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACCTGATGGA AGAA ACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGATGATGCG GATA GGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACGCAATACT ACGT CCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCTTCGGCAA AGTT CAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGCTGAATCC CAGA CGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGTACCGAGT TCTA CAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTTTCAAACA TTTC TTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCATGCCGAC TTCT TTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGCTCCCTTC TTAC TTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAGGCTTCCA CCTC TTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCCGTTAAAC AAAA TTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACATCCGGTGA CAGC TCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAGTTCAAGT GAAA CTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAGCCCAATT GTAA AACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTACAGTCGCTCGGCGATC GAAG GCTTCGGAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAAT TCTT TTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGT TTGT GATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATT TGAT TCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTA CAGA ACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAG CAAA CGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAA GAGC AGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACC TGAT GGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGA TGAT GCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACG CAAT ACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCT TCGG CAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGC TGAA TCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGT ACCG AGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTT TCAA ACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCA TGCC GACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGC TCCC TTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAG GCTT CCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCC GTTA AACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACAT CCGG TGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAG TTCA AGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAG CCCA ATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTAGGATCAGCT GTAC GTACTCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCATGTTTCACGTACTAAGC TCTC ATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTCATGGCTAACGTACTAA GCTC TCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTGAACAATA AAAT TAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAAGA ATAT ATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACAAGCCAGGGATGTAACG CACT GAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGGAACACTTAACGGCTGA CATG GGGCGGCCGCGTAG

[00241] SEQ ID NO: 85 (Plasmid encoding oxalate degradation pathway for genomic integration into Bacteroides vulgatus genome):

GGAGAGCTGTATGTGGGGTGGAAGAAGCTATCGTAAAAATGCTGGAGCAGCTTGATC CTCATTC TACCTATTCTGATCCGGAGGAAGTGAAGAGAATGAACGAGCCGTTGCAGGGAAACTTCGA AGGT ATCGGTATACAGTTTAATATGGCGGAGGACACTTTGCTGGTGATACAGCCTGTATCGGGC GGAC CGTCCGAAAAAGTCGGTATTCTGGCCGGTGATCGTATCGTCATGGTGGAAGATACGCTGA TAGC CGGTGTAAAGATGAGTACCGAGGATATTATGCGTCGCCTCCGTGGTCCTAAAGATTCAAA AGTG AATCTGAAAATACTTCGCCGAGGGGTGAAGGAACTGCTCCCCTTTACGGTGAAAAGGGAT AAAA TACCTGTTTACAGCTTGGATGCTTCCTATATGATTAAAGATAAGATCGGTTATATTCGTA TCAA CCGTTTTGCCGCCACTACCCATGAGGAGTTCAAGAAAGCGCTGACCGGGTTGCAGAAGAA AGGA ATGAAAGACTTGATTCTTGATTTGCAGGGCAATGGCGGGGGGTATTTGAATGCTGCTATC GATA TTGCCAATGAATTTTTGGGTAAAAAGGAACTGATTGTCTATACGGAGGGCCGTCGTAATC CTCG TAGCGAGTTTTTTGCCAAAGGTACGGGCGAGTTTCAGAACGGTCGTCTGATGGTATTGGT TGAT GAATTTTCGGCTTCTGCCAGTGAGATTGTGACCGGAGCTGTTCAGGATTGGGACAGAGGC GTTG TGGTAGGCCGTCGCAGTTTTGGTAAAGGCTTGGTGCAGCGTCCCATTGATTTGCCGGACG GTTC GATGATCCGTCTGACGGTGGCCCGCTATTATACGCCTGCCGGACGTTGTATCCAGAAACC TTAC GAGAGCATTGAAAAGTATAATGAAGACCTGATAGACCGTTATAATAAAGGAGAAATGATG AGTG AAGACAGCATCCACTTTCCGGATTCACTGAAGTTCAAGACTCATAGGTTGGCCCGTACGG TATA TGGTGGCGGAGGGATCATGCCCGATTATTTTGTGCCGATTGATACGACTCTCTATACTAA ATAC CATCGTCAGTTGCGTGATAAAGGAGCATTGATGAAAGCTCATTTCCATTTTATTGATGCC CATC GTAAAGAATGGCTGGGCAAATACAAGACTTTCAATGAGTTCTACAAACGTTTTGAAGTGA CTCC GGATATGTTGACACAACTGGTTGCTACCGGCAAGGAGATGGGAGTGGAATATAATGAAGA AGAG TATCAAAAGGCCCTGCCTCTGCTGAGGTTGCAGATGAAAGCATTGATAGCCCGTGATTTA TGGG ATATGAATGAATATTATCACGTCATTAATGACGCGAATGAAAGTATCAGGAAAGCGCTGG AACT GTTGGAGCAACCGGACTTTGAGGGGCTGCTGTTGAAAAAGCGATAGTCAAGACTTTATAT TAAC TGCAGGGGCGCATAGTTGCACTCCTGCAGTTGTCTGAAAAACTTGTAGGATAAAACGAAA GGCT CAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGC AATG GTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTT GCAG TGTCGAAAGAAACAAAGTAGCCTGGCATCACCTAAAAATTATAAATAAATTAATAAACCA CAAT ACTAAAAATTTAATAAAATGAATAATCCACAAACAGGACAATCAACAGGCCTCTTGGGCA ATCG TTGGTTCTACTTGGTATTAGCAGTTTTGCTGATGTGTATGATCTCGGGTGTCCAATATTC CTGG ACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACG GCTT TCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATA AATT CGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCAT GGGT ATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGT ATCG TTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTT CCGG TTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGT TCTG AAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTTTGATCATGGGTATCCTGATT ATCC TGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTA CCGA CAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAATTCTGGGTTCTGTGGACCGC ATTC TTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGC CTCG GTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTT GCCG TCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTT CGGT ATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTT ATCG CCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCA ACAG CGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGC AACT GCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAACCAACTTCGGATGGAATACC GCTT TCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAA GAAT GGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAAGAAAAAGCTGTACATTAAGG TTCC TAACCTGCCTGGCATCATCTACCTATATTAATCATCAACCCAATTTTCATATGTATAAAA TTAA CAAAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTAGCGTATCCGA TAAT GTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCTATCCCACATG GTGG GTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCTGTTTTCAGAC AAGA TACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCCTCGGTGCTAC TATG GACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTTCAATTTTTAT TTGA ATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTACAGAGTTCTG AAAT TCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCGATGCGACCAG GTTT AGGGTAGAGTATGATATATACTCTCCAGAGGACAACTACAAAAGGGTTATTTACCGGTCT TTGA ACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCCCGTTCCAGTG ACGT TGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGCCTTTGTTACA TTTG AACATTGTGAGAAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCCCTTGGACAGA TCTT ATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTTTCCACTTTTA GAAC TCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGGACCAATTTGT TAAG TACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCTGAACATGCCC AAAC CAAACCCTTTCCCACACATTAGATTCATCAGATCGTGTTCTTCTGCTTTGGCTCCAGCAA CGTT CCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGATGACCGAAGC ATCA CATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTACTGTGGGCCAG CCAC AAGGAGTCACCGTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCGGGCAAAGTCG GCGA AGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAAAAGCTAACAA GGAG AACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTTCGACCCTGAG GGGT TTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAAAAGATTTCAC CCAT TGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTGCATTTGGTGT TCCC GACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGGAGAAAAAATG ACCT ACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATTCCAACCAAGG TGTA CTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAGTTATCGCAGA AACT TTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGGTTCCTAAACGACCTGGCATCAA CTAC CTTTATTATTCAACAAACCAATTTAACATATTAAAAAAATAAAAAAATGACTACCACAGC AACG CAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCGGCATAGTAGGT ATTC CGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTATACCGTGTCGCA ATGA GCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAACCTGGTGTCCT GTTA ATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATAGTATGTCGAAC CGCT GGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAAGGGAGGTTTCC AGGA ACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAACTGACGCCGGA TAAC ATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCGCCGGAGTGAGC TATA TCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAATGATAGAACTG GTAA CGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGTAAAATTAAGAA GGTG GTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAGGTAAAGGAGCA GTGA AGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTTCCTTCCGACTC CCAT GGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCCCGGAGCCAGGC TCTT AAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCCTTCACTTCGGA ACGA GTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCCGGAAACGCTCG GAGA CAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGACTATCGGTTAC TGCA CTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAGTCAAACAGGAG ATCA GGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAACGCGTGGAGCTC AGCT TAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTATCGCACGATCTT GGTC ACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTGATGCACCTCGC AGAA GACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGCATTAGCGTGTA AAGC CAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTCGGTTTTAGCGC TATG GAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAATGAATAACTCT GGGA TATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTTGTCAAAAAATT GTAG ATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAATACCATCTCAGA GTTA TCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAACCTCCGTCATT AATG TCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAACAAGCCTAGAC TGTA AGGTTCCTAAGGGTCCTGGCATCTAAACTAAAATACAATAACCAAAAATCATGTTTAACA AATA AAAATAATAAAATGGATAGCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAAAAAT TCCC CGATCGCCGAGCTCTCTCCGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTCACGA TCTA ATCGAACGCGCCGCTTCACGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGTCGTT GCTC TCACCTTCCCTAACACCGTCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCTAGAG CCAC GGCGGCGCCGTTGAACGCAGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCGATTC AGAT TCAAAGCTATTGTTAACCTCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAG CTGA AAATCTCTCACGTCACCGCTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCCGTTG CGGA TTCAGATTCCGTCGTTGACTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTGCTCT CTTC CTCCACACTTCTGGCACTACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAATCTA GCTT CATCCGTCAAGAACATTAAAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTGATTG TTCT CCCTCTGTTCCATGTTCATGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGC TGCT GTAACTCTTCCAGCTGCTGGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAAGAAG TATA ACGCTACATGGTATACTGCTGTGCCGACCATTCATCAGATCATATTGGACCGCCACGCGA GCCA CCCTGAAACGGAATATCCTAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCC GGTG ATATTGTCCAGGCTTGAGGAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAATGACA GAGG CAACACATTTGATGAGCTCAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGGTCTG TTGG GAAACCGGTAGGTCAAGAAATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAA TAAC AAAGGAGAGGTTTGTATAAGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCCAGAA GCCA ACAAGGCAGGTTTCGAGTTTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGATACCG ATGG GTATTTGCATCTGGTGGGTCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGATATC TCCA ATTGAAGTGGATGCAGTACTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATTCGGT GTTC CTGATGAGAAATATGGGGAAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACTACTG TAAC CGAAGAGGACATTAAAGCGTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAG AGTG TTCATCACTGATAACCTCCCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCA CAAC ATTTCCTTGAGAAGCCCTGAGGTTCCTAATTCCCCTGGCATCATCTACCTATATTACTAA ACAA ACCAATTATAATAATTTTAAAAATAAAAAAATGACAAATAATGAAAGCAAAGGGCCGTTT GAAG GCTTATTAGTTATCGATATGACACATGTCCTTAATGGACCTTTCGGAACTCAACTTCTTT GTAA TATGGGCGCAAGGGTAATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACCCGCACATT TGGT CCCTATGTGGATGGACAGTCACTCTATTACAGTTTTATTAATCATGGCAAAGAGAGTGTG GTTC TTGATTTAAAGAATGATCACGATAAAAGTATATTTATAAATATGCTCAAACAAGCTGATG TATT AGCTGAGAATTTTCGCCCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAAACGCTTCA AGAA ATCAACCCGCGCCTCATATATGCTTCATCGTCAGGTTTCGGACATACCGGTCCGCTAAAA GATG CTCCTGCCTACGATACCATCATTCAGGCAATGAGCGGGATAATGATGGAAACAGGATATC CTGA TGCTCCGCCAGTGCGCGTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTCTATTTATT CAGC GGAATAGTGAGTGCACTTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATGTCGATATA GCGA TGTTTGATGCCACGCTGAGTTTTCTGGAGCATGGTCTGATGGCATATATCGCAACTGGGA AGTC ACCACAACGTCTGGGAAATCGCCATCCCTACATGGCACCTTTTGATGTTTTCAATACTCA GGAT AAGCCGATTACGATTTGTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCCAGGCACTG GAGC TTACGGAACTGGTTAATGATCCCCGATTTAGCAGCAATATTTTACGCGTACAAAACCAGG CTAT TCTTAAACAATATATTGAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGGTTAGCCAG AATA CATGAAGTTGGTGTACCCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTAAATTGCCA CAAA CTCAGGCGAGAAATATGTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAATCCGATAA AAAT CAGCGGCTGCGCGGACCCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAGCATGGGGA ACAA ATTCGCCAGGAGTTCTCATCATAAGGTTCCTAAAATGCCTGGCATCATCTACCTAAATTA ATAA ACAACCCATTTATAAACCCTTTAAAATTAACAAAATGTCAACTCCACTTCAAGGAATTAA AGTT CTCGATTTCACCGGTGTGCAATCTGGCCCATCTTGTACTCAAATGCTGGCCTGGTTTGGC GCTG ACGTTATTAAAATTGAACGTCCCGGCGTTGGTGACGTAACGCGTCACCAGCTGCGAGATA TTCC TGATATCGATGCGCTTTACTTCACCATGCTTAACAGTAACAAACGTTCTATTGAGTTAAA TACC AAAACAGCGGAAGGCAAAGAGGTAATGGAAAAGCTGATCCGCGAAGCTGATATCTTAGTC GAGA ACTTTCATCCAGGGGCCATTGATCACATGGGCTTCACCTGGGAGCATATTCAAGAAATCA ATCC ACGTCTGATTTTTGGTTCGATCAAAGGGTTTGATGAGTGTTCGCCTTATGTGAATGTAAA AGCC TATGAAAACGTTGCTCAGGCAGCGGGTGGCGCGGCATCCACTACGGGTTTTTGGGATGGT CCGC CGCTGGTAAGCGCTGCAGCGTTGGGTGACAGCAACACCGGAATGCATTTGCTGATCGGTT TACT TGCTGCTTTGCTGCATCGCGAAAAAACGGGGCGTGGGCAACGAGTCACCATGTCAATGCA GGAT GCCGTATTGAACCTTTGCCGCGTGAAATTACGTGACCAGCAGCGTCTAGATAAATTGGGT TATC TGGAAGAATACCCGCAGTATCCGAATGGTACATTTGGTGATGCAGTTCCCCGCGGTGGTA ATGC AGGTGGTGGCGGTCAGCCTGGCTGGATCCTGAAATGTAAAGGCTGGGAAACCGATCCTAA CGCC TATATTTATTTCACTATTCAGGAGCAAAACTGGGAAAACACCTGTAAAGCCATCGGCAAA CCAG AATGGATTACCGATCCGGCATACAGTACAGCCCATGCACGACAGCCACATATTTTCGATA TTTT TGCTGAAATCGAAAAATACACTGTCACTATTGATAAACATGAAGCGGTGGCCTATTTGAC TCAG TTTGATATTCCTTGTGCACCGGTTTTAAGTATGAAAGAAATTTCACTTGATCCCTCTTTG CGCC AAAGTGGCAGTGTTGTTGAAGTGGAACAACCGTTGCGTGGAAAATATCTGACCGTTGGTT GTCC AATGAAATTCTCTGCCTTTACGCCGGATATTAAAGCTGCGCCGCTATTAGGTGAACATAC CGCT GCTGTATTGCAGGAGCTGGGTTATAGCGACGATGAAATTGCTGCAATGAAGCAAAACCAC GCCA TCTGAGGTTCCTAAAAACCCTGGCATCAACTACCTAAATTAATTATCACCCCAAATTAAT AACA TAAAAATATAATAAAATGAGTAACGACGACAATGTAGAGTTGACTGATGGCTTTCATGTT TTGA TCGATGCCCTGAAAATGAATGACATCGATACCATGTATGGTGTTGTCGGCATTCCTATCA CGAA CCTGGCTCGTATGTGGCAAGATGACGGTCAGCGTTTTTACAGCTTCCGTCACGAACAACA CGCA GGTTATGCAGCTTCTATCGCCGGTTACATCGAAGGAAAACCTGGCGTTTGCTTGACCGTT TCCG CCCCTGGCTTCCTGAACGGCGTGACTTCCCTGGCTCATGCAACCACCAACTGCTTCCCAA TGAT CCTGTTGAGCGGTTCCAGTGAACGTGAAATCGTCGATTTGCAACAGGGCGATTACGAAGA AATG GATCAGATGAATGTTGCACGTCCACACTGCAAAGCTTCTTTCCGTATCAACAGCATCAAA GACA TTCCAATCGGTATCGCTCGTGCAGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTGTTT ACGT TGACTTGCCAGCAAAACTGTTCGGTCAGACCATTTCTGTAGAAGAAGCTAACAAACTGCT CTTC AAACCAATCGATCCAGCTCCGGCACAGATTCCTGCTGAAGATGCTATCGCTCGCGCTGCT GACC TGATCAAGAACGCCAAACGTCCAGTTATCATGCTGGGTAAAGGCGCTGCATACGCACAAT GCGA CGACGAAATCCGCGCACTGGTTGAAGAAACCGGCATCCCATTCCTGCCAATGGGTATGGC TAAA GGCCTGCTGCCTGACAACCATCCACAATCCGCTGCTGCAACCCGTGCTTTCGCACTGGCA CAGT GTGACGTTTGCGTACTGATCGGCGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAGGCA AAAC CTGGGGCGACGAACTGAAGAAATACGTTCAGATCGACATCCAGGCTAACGAAATGGACAG CAAC CAGCCTATCGCTGCACCAGTTGTTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGCAAA GCAC TGAAAGGCGCTCCAAAAGCTGACGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTGACG GCAA CAAAGCCAAACTGGCTGGCAAGATGACTGCCGAAACCCCATCCGGAATGATGAACTACTC CAAT TCCCTGGGCGTTGTTCGTGACTTCATGCTGGCAAATCCGGATATTTCCCTGGTTAACGAA GGCG CTAATGCACTCGACAACACTCGTATGATTGTTGACATGCTGAAACCACGCAAACGTCTTG ACTC CGGTACCTGGGGTGTTATGGGTATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGTTAC CGGC AAACCGGTTATCGCTGTTGAAGGCGATAGCGCATTCGGTTTCTCCGGTATGGAACTGGAA ACCA TCTGCCGTTACAACCTGCCAGTTACCGTTATCATCATGAACAATGGTGGTATCTATAAAG GTAA CGAAGCAGATCCACAACCAGGCGTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTACGA CATG ATGATGGAAGCATTTGGCGGTAAAGGTTATGTTGCCAATACTCCAGCAGAACTGAAAGCT GCTC TGGAAGAAGCTGTTGCTTCCGGCAAACCATGCCTGATCAACGCGATGATCGATCCAGACG CTGG TGTCGAATCTGGCCGTATCAAGAGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAATAAGG TTCC TAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTCTGTTGTGTCTTCTT TTAG GTGTGGAATAATTTTCCAACCATCACTTTATCTGTCTCCCGAACAGCACCTTATTCAGCC ATCG GTTCACATACACGTTCACGAAAGCACATCCTACTCCGATAGCGGCTCCTGCCACTACATC ACTG GGATAGTGCACCCCTTGGTTCATCCGGGCAAACCCTACTCCGCAAGCCCATACGGCTGAA GGGG CGATAACATACCACTTAGGATAAGTGATGGAGAGTGAGGTGGCTAAAGAAAAAGCTGCCG CAGT GTGTCCTGAAGGGAATGACGGACTATCGGCATCCGGTGCTCCGTATGCATGAATCTTATC CGGA TACTTTACAAAAGGCCGGTCACGACCTATTATATGTTTGGCGGCGTATGTAATCCCCACT GCTT CAATCACACTGGTTCCTATGTAAATGGCATCTTTCAGCATCGGCTGGTCTTTCTTTATCA ATGC ATAGAGTCCCATGGCTGTAGGTATTCCTACGGGTAGAATCACTCCGCTAGCGGACAATCC GCGG CTCAGTCCGTGTACATCCCATCGGTTGATGGTTTTCAACGTGTTGATGTCTATATTCTGT GCGC TGAGGCTGAATGTAAAACAGGCTGTCAGTATAAGAAAAATAATCCTTTGGCGTTTCATTT AGTT TGGCATTTGTTCAGTGCAAAGATAGGAAAATAATGTAATTCGCATTTACCCTTCCCCGAA TTAA AGAATAATTTCCATAATTCCTTGTATTATCGCTAGAATTCCTTTACTTTTGCATCGTGAA TACA CAGCTTTTAACAGAATTTTTAGTTCTAACAATTAAATAATTTAAATTCAATCATTTATGT GGTT AAGTAATTCATCTATTGGAAGGAAAGTGGTGATGAGTGTCACAGGTATCGCCCTTGTCCT GTTT CTGACGTTTCACATGGCGATGAACCTTGTTGCGCTCTTCTCGGAAGATGCTTACAACATG ATTT GTGAATTCTTGGGAGCTAACTGGTACGCGTTGGTTGCAACTGCCGGGCTGGCTGCTCTGT TTGT AATTCACATCATCTACGCTTTCTGGTTGACCATGCAGAACCGTGCAGCTCGCGGTAGCGA ACGT TATGCAGTGAACGTTAAACCTAAAACTGTGGAATGGGCATCTCAGAACATGCTTGTCCTG GGTA TTGTCGTTATTGCCGGATTGGCTCTTCATTTTGCCAATTTCTGGTACAAAATGCAGTTTG CCGA AATTATCGGTGTTCATGATTTGGGCGCATTCGGTCCTACAGACGGTGCCGCTTACATTCG TGAA ACATTCGGATGCCCTGTATTTACAGTGCTTTACCTCATTTGGTTAGCAGCTTTGTGGTTC CACC TGACTCACGGATTCTGGAGTGCTTTGCAGACTTTGGGCTGGAGCAATAAAATCTGGTTCG AGCG TTGGAAGACTATTGGTAACATCTACTCTACTTTGGTAGTTCTTGGTTTTGCAGCAGTAGT CGTT ATCTACTTCGCTATGACTGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGT TTCA TCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCA GGAT TCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGG GTGG GCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACG AACC CTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATA ATGA CCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCGGGGATTGGTGAACAAA AAGG TGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGATATTGAGGTATCATTTT ATCG TAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAAATTTTAGCATTTTGTA AAAA AGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTTGCATCCCGAAGAGTTT CTCT TAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTTTATGTCGTAAAGAGGG GCTT TGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTAGTTGAAACACATAGAA AGTT GCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTACGTTCTTTTCTCAAAA AACA TAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAATGAACAAAGTAAATAT AAAA GATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAATAATGAATTGCATAAGT TTAG ATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCATTTTACTGCTGGATTGG TAAA GAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTATGTGAGGTAACTCGTAA TAAG CTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACTGAAATTTACATTTCCT AGCC ACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGCACAAATATAATTCGAA AAAT TGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAATATGGTTTTGCTAAAAT GTTA TTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGTAGATATTTCTATATTA GCAA AAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGCACATTAATTGTATTAA AAAG AAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAACTTTTGTAATGAAATG GGTT AACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAAAGCTTTAAAACATGCG AGAA TATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTATTTAATAGTTATAAAA TATT TAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTACGCGGGTACCGACACCG CGGT GGAGGGGAATTGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCATC AAAT GAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTTCT GTAA TGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTGC GATT CCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATCA AGTG AGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCTT TCCA GACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAACC GTTA TTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGACAATTA CAAA CAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCTG AATC AGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAACCA TGCA TCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCAG TTTA GTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAACA ACTC TGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTATC GCGA GCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGGAGCAA GACG TTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAGTT TTAT TGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACAAC GTGG CTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGAGCCTACGTTCCGAATAC GGTC AAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAATTCTTTTA GGAA GCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGTTTGTGAT ACGC TCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATTTGATTCA AGTA CGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTACAGAACG GACA TCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAGCAAACGG GAAG TAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAAGAGCAGC AATA CCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACCTGATGGA AGAA ACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGATGATGCG GATA GGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACGCAATACT ACGT CCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCTTCGGCAA AGTT CAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGCTGAATCC CAGA CGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGTACCGAGT TCTA CAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTTTCAAACA TTTC TTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCATGCCGAC TTCT TTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGCTCCCTTC TTAC TTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAGGCTTCCA CCTC TTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCCGTTAAAC AAAA TTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACATCCGGTGA CAGC TCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAGTTCAAGT GAAA CTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAGCCCAATT GTAA AACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTACAGTCGCTCGGCGATC GAAG GCTTCGGAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAAT TCTT TTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGT TTGT GATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATT TGAT TCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTA CAGA ACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAG CAAA CGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAA GAGC AGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACC TGAT GGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGA TGAT GCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACG CAAT ACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCT TCGG CAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGC TGAA TCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGT ACCG AGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTT TCAA ACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCA TGCC GACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGC TCCC TTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAG GCTT CCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCC GTTA AACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACAT CCGG TGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAG TTCA AGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAG CCCA ATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTAGGATCAGCT GTAC GTACTCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCATGTTTCACGTACTAAGC TCTC ATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTCATGGCTAACGTACTAA GCTC TCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTGAACAATA AAAT TAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAAGA ATAT ATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACAAGCCAGGGATGTAACG CACT GAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGGAACACTTAACGGCTGA CATG GGGCGGCCGCGTAG [00242] SEQ ID NO: 86 (Plasmid encoding oxalate degradation pathway for genomic integration into Bacteroides vulgatus genome):

GGAGAGCTGTATGTGGGGTGGAAGAAGCTATCGTAAAAATGCTGGAGCAGCTTGATC CTCATTC TACCTATTCTGATCCGGAGGAAGTGAAGAGAATGAACGAGCCGTTGCAGGGAAACTTCGA AGGT ATCGGTATACAGTTTAATATGGCGGAGGACACTTTGCTGGTGATACAGCCTGTATCGGGC GGAC CGTCCGAAAAAGTCGGTATTCTGGCCGGTGATCGTATCGTCATGGTGGAAGATACGCTGA TAGC CGGTGTAAAGATGAGTACCGAGGATATTATGCGTCGCCTCCGTGGTCCTAAAGATTCAAA AGTG AATCTGAAAATACTTCGCCGAGGGGTGAAGGAACTGCTCCCCTTTACGGTGAAAAGGGAT AAAA TACCTGTTTACAGCTTGGATGCTTCCTATATGATTAAAGATAAGATCGGTTATATTCGTA TCAA ATGAAAGACTTGATTCTTGATTTGCAGGGCAATGGCGGGGGGTATTTGAATGCTGCTATC GATA TTGCCAATGAATTTTTGGGTAAAAAGGAACTGATTGTCTATACGGAGGGCCGTCGTAATC CTCG TAGCGAGTTTTTTGCCAAAGGTACGGGCGAGTTTCAGAACGGTCGTCTGATGGTATTGGT TGAT GAATTTTCGGCTTCTGCCAGTGAGATTGTGACCGGAGCTGTTCAGGATTGGGACAGAGGC GTTG TGGTAGGCCGTCGCAGTTTTGGTAAAGGCTTGGTGCAGCGTCCCATTGATTTGCCGGACG GTTC GATGATCCGTCTGACGGTGGCCCGCTATTATACGCCTGCCGGACGTTGTATCCAGAAACC TTAC GAGAGCATTGAAAAGTATAATGAAGACCTGATAGACCGTTATAATAAAGGAGAAATGATG AGTG AAGACAGCATCCACTTTCCGGATTCACTGAAGTTCAAGACTCATAGGTTGGCCCGTACGG TATA TGGTGGCGGAGGGATCATGCCCGATTATTTTGTGCCGATTGATACGACTCTCTATACTAA ATAC CATCGTCAGTTGCGTGATAAAGGAGCATTGATGAAAGCTCATTTCCATTTTATTGATGCC CATC GTAAAGAATGGCTGGGCAAATACAAGACTTTCAATGAGTTCTACAAACGTTTTGAAGTGA CTCC GGATATGTTGACACAACTGGTTGCTACCGGCAAGGAGATGGGAGTGGAATATAATGAAGA AGAG TATCAAAAGGCCCTGCCTCTGCTGAGGTTGCAGATGAAAGCATTGATAGCCCGTGATTTA TGGG ATATGAATGAATATTATCACGTCATTAATGACGCGAATGAAAGTATCAGGAAAGCGCTGG AACT GTTGGAGCAACCGGACTTTGAGGGGCTGCTGTTGAAAAAGCGATAGTCAAGACTTTATAT TAAC TGCAGGGGCGCATAGTTGCACTCCTGCAGTTGTCTGAAAAACTTGTAGGATAAAACGAAA GGCT CAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGC AATG GTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTT GCAG TGTCGAAAGAAACAAAGTAGCCTGGCATCACCTAAAAATTATAAATAAATTAATAAACTT TTAT TAAAAAAAAATTACAAAATGAATAATCCACAAACAGGACAATCAACAGGCCTCTTGGGCA ATCG TTGGTTCTACTTGGTATTAGCAGTTTTGCTGATGTGTATGATCTCGGGTGTCCAATATTC CTGG ACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACG GCTT TCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATA AATT CGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCAT GGGT ATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGT ATCG TTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTT CCGG TTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGT TCTG AAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTTTGATCATGGGTATCCTGATT ATCC TGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTA CCGA CAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAATTCTGGGTTCTGTGGACCGC ATTC TTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGC CTCG GTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTT GCCG TCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTT CGGT ATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTT ATCG CCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCA ACAG CGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGC AACT GCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAACCAACTTCGGATGGAATACC GCTT TCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAA GAAT GGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAAGAAAAAGCTGTACATTAAGG TTCC TAACCTGCCTGGCATCTTAATCAATTTTAAACTCACCAAATCAAAATATGAAAAAAAAAA ATAA TAAAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGG CCCA TCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGC GTTG GTGACGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTTTACTTCACCA TGCT TAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAAT GGAA AAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCAC ATGG GCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAG GGTT TGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGG TGGC GCGGCATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGT GACA GCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAA CGGG GCGTGGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAA ATTA CGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAAT GGTA CATTTGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGA TCCT GAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTATTCAGGAGCA AAAC TGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCCGGCATACAGT ACAG CCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCA CTAT TGATAAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTT AAGT ATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAA CAAC CGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGG ATAT TAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAG CGAC GATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTAAACGACCTGGCAT CAAC TACCTTTATTATTCAACAAACCAATTTAACATATTAAAAAAATAAAAAAATGACTACCAC AGCA ACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCGGCATAGTA GGTA TTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTATACCGTGTC GCAA TGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAACCTGGTGT CCTG TTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATAGTATGTCG AACC GCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAAGGGAGGTT TCCA GGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAACTGACGCC GGAT AACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCGCCGGAGTG AGCT ATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAATGATAGAA CTGG TAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGTAAAATTAA GAAG GTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAGGTAAAGGA GCAG TGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTTCCTTCCGA CTCC CATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCCCGGAGCCA GGCT CTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCCTTCACTTC GGAA CGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCCGGAAACGC TCGG AGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGACTATCGGT TACT GCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAGTCAAACAG GAGA TCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAACGCGTGGAG CTCA GCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTATCGCACGAT CTTG GTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTGATGCACCT CGCA GAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGCATTAGCGT GTAA AGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTCGGTTTTAG CGCT ATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAATGAATAAC TCTG GGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTTGTCAAAAA ATTG TAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAATACCATCTC AGAG TTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAACCTCCGTC ATTA ATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAACAAGCCTA GACT GTAAGGTTCCTAAGGGTCCTGGCATCAACTACCTAAATTACTTATCAAACCACTTAGTAG TAAA AAAAATATAACAAAATGACAAATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTA TCGA TATGACACATGTCCTTAATGGACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAG GGTA ATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACCCGCACATTTGGTCCCTATGTGGAT GGAC AGTCACTCTATTACAGTTTTATTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGA ATGA TCACGATAAAAGTATATTTATAAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTT TCGC CCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGC CTCA TATATGCTTCATCGTCAGGTTTCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACG ATAC CATCATTCAGGCAATGAGCGGGATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGT GCGC GTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGT GCAC TTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCA CGCT GAGTTTTCTGGAGCATGGTCTGATGGCATATATCGCAACTGGGAAGTCACCACAACGTCT GGGA AATCGCCATCCCTACATGGCACCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACG ATTT GTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGG TTAA TGATCCCCGATTTAGCAGCAATATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATA TATT GAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGT GTAC CCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAA ATAT GTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGC GGAC CCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAG TTCT CATCATAAGGTTCCTAATTCCCCTGGCATCTTTTCCATAACAAAAATTAAACCTCCTCCA TATG AAAAATAAAAATTATAAAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCAACGATACT TTTA GCGTATCCGATAATGTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGACCTACAGGG ATCT ATCCCACATGGTGGGTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCATTGTACGG AGCT GTTTTCAGACAAGATACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTATCGTCGCT TTCC TCGGTGCTACTATGGACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGG AGTT CAATTTTTATTTGAATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAA GTTA CAGAGTTCTGAAATTCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCC TTCG ATGCGACCAGGTTTAGGGTAGAGTATGATATATACTCTCCAGAGGACAACTACAAAAGGG TTAT TTACCGGTCTTTGAACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTCCCTGGGTT TGCC CGTTCCAGTGACGTTGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTCCAAAAACG GTGC CTTTGTTACATTTGAACATTGTGAGAAGCACGTTGAACATTGCTAACACTTACAAGCTAA CGCC CTTGGACAGATCTTATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTT ACTT TCCACTTTTAGAACTCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAAAGTTATTC TGGG ACCAATTTGTTAAGTACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAGCATGATTA TGCT GAACATGCCCAAACCAAACCCTTTCCCACACATTAGATTCATCAGATCGTGTTCTTCTGC TTTG GCTCCAGCAACGTTCCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGGAGGCCTAT GCGA TGACCGAAGCATCACATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTG GTAC TGTGGGCCAGCCACAAGGAGTCACCGTCGTCATTCTAGATGACAATGACAATGTCTTGCC CCCG GGCAAAGTCGGCGAAGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATGCTAATAAT CCAA AAGCTAACAAGGAGAACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGACCAAGGTT ATTT CGACCCTGAGGGGTTTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGG TGAA AAGATTTCACCCATTGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCGATGAAGCC GTTG CATTTGGTGTTCCCGACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGA AGGG AGAAAAAATGACCTACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAA AATT CCAACCAAGGTGTACTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAATCCAGAGA AGAG TTATCGCAGAAACTTTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGGTTCCTAAA ATGC CTGGCATCAACTACCTAAATTAATTATCACCCCAAATTAATAACATAAAAATATAATAAA ATGA GTAACGACGACAATGTAGAGTTGACTGATGGCTTTCATGTTTTGATCGATGCCCTGAAAA TGAA TGACATCGATACCATGTATGGTGTTGTCGGCATTCCTATCACGAACCTGGCTCGTATGTG GCAA GATGACGGTCAGCGTTTTTACAGCTTCCGTCACGAACAACACGCAGGTTATGCAGCTTCT ATCG CCGGTTACATCGAAGGAAAACCTGGCGTTTGCTTGACCGTTTCCGCCCCTGGCTTCCTGA ACGG CGTGACTTCCCTGGCTCATGCAACCACCAACTGCTTCCCAATGATCCTGTTGAGCGGTTC CAGT GAACGTGAAATCGTCGATTTGCAACAGGGCGATTACGAAGAAATGGATCAGATGAATGTT GCAC GTCCACACTGCAAAGCTTCTTTCCGTATCAACAGCATCAAAGACATTCCAATCGGTATCG CTCG TGCAGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTGTTTACGTTGACTTGCCAGCAAA ACTG TTCGGTCAGACCATTTCTGTAGAAGAAGCTAACAAACTGCTCTTCAAACCAATCGATCCA GCTC CGGCACAGATTCCTGCTGAAGATGCTATCGCTCGCGCTGCTGACCTGATCAAGAACGCCA AACG TCCAGTTATCATGCTGGGTAAAGGCGCTGCATACGCACAATGCGACGACGAAATCCGCGC ACTG GTTGAAGAAACCGGCATCCCATTCCTGCCAATGGGTATGGCTAAAGGCCTGCTGCCTGAC AACC ATCCACAATCCGCTGCTGCAACCCGTGCTTTCGCACTGGCACAGTGTGACGTTTGCGTAC TGAT CGGCGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAGGCAAAACCTGGGGCGACGAACT GAAG AAATACGTTCAGATCGACATCCAGGCTAACGAAATGGACAGCAACCAGCCTATCGCTGCA CCAG TTGTTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGCAAAGCACTGAAAGGCGCTCCAA AAGC TGACGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTGACGGCAACAAAGCCAAACTGGC TGGC AAGATGACTGCCGAAACCCCATCCGGAATGATGAACTACTCCAATTCCCTGGGCGTTGTT CGTG ACTTCATGCTGGCAAATCCGGATATTTCCCTGGTTAACGAAGGCGCTAATGCACTCGACA ACAC TCGTATGATTGTTGACATGCTGAAACCACGCAAACGTCTTGACTCCGGTACCTGGGGTGT TATG GGTATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGTTACCGGCAAACCGGTTATCGCT GTTG AAGGCGATAGCGCATTCGGTTTCTCCGGTATGGAACTGGAAACCATCTGCCGTTACAACC TGCC AGTTACCGTTATCATCATGAACAATGGTGGTATCTATAAAGGTAACGAAGCAGATCCACA ACCA GGCGTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTACGACATGATGATGGAAGCATTT GGCG GTAAAGGTTATGTTGCCAATACTCCAGCAGAACTGAAAGCTGCTCTGGAAGAAGCTGTTG CTTC CGGCAAACCATGCCTGATCAACGCGATGATCGATCCAGACGCTGGTGTCGAATCTGGCCG TATC AAGAGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAATAAGGTTCCTAAAAACCCTGGCAT CTAA ACTAAAATACAATAACCAAAAATCATTACAAATGAAAAAAAATAATAAAATGGATAGCGA TACT CTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCCCGATCGCCGAGCTCTCTCCGTT TCTG GAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTAATCGAACGCGCCGCTTCACGCC TTGT CTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTCTCACCTTCCCTAACACCGTCGA GTTT GTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCACGGCGGCGCCGTTGAACGCAGCG TACA CGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGATTCAAAGCTATTGTTAACCTCTA AAGA AGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGAAAATCTCTCACGTCACCGCTAC GCTG CTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGATTCAGATTCCGTCGTTGACTCA GCGA CGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTCCTCCACACTTCTGGCACTACGA GCCG TCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTTCATCCGTCAAGAACATTAAAGC TGTG TACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCTCCCTCTGTTCCATGTTCATGGA TTGT TAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCTGTAACTCTTCCAGCTGCTGGTA GATT CTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATAACGCTACATGGTATACTGCTGT GCCG ACCATTCATCAGATCATATTGGACCGCCACGCGAGCCACCCTGAAACGGAATATCCTAAA CTCC GGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTGATATTGTCCAGGCTTGAGGAAG CGTT TGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGGCAACACATTTGATGAGCTCAAA CCCC TTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGGGAAACCGGTAGGTCAAGAAATG GCGA TCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAACAAAGGAGAGGTTTGTATAAGAG GTCC AAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCAACAAGGCAGGTTTCGAGTTTGG GTGG TTCCACACTGGTGATATCGGTTACTTTGATACCGATGGGTATTTGCATCTGGTGGGTCGG ATCA AAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCAATTGAAGTGGATGCAGTACTCT TAAC GCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTCCTGATGAGAAATATGGGGAAGA GATT AACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAACCGAAGAGGACATTAAAGCGTTT TGTA AGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTGTTCATCACTGATAACCTCCCCA AAAC TGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAACATTTCCTTGAGAAGCCCTGAGG TTCC TAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTCTGTTGTGTCTTCTT TTAG GTGTGGAATAATTTTCCAACCATCACTTTATCTGTCTCCCGAACAGCACCTTATTCAGCC ATCG GTTCACATACACGTTCACGAAAGCACATCCTACTCCGATAGCGGCTCCTGCCACTACATC ACTG GGATAGTGCACCCCTTGGTTCATCCGGGCAAACCCTACTCCGCAAGCCCATACGGCTGAA GGGG CGATAACATACCACTTAGGATAAGTGATGGAGAGTGAGGTGGCTAAAGAAAAAGCTGCCG CAGT GTGTCCTGAAGGGAATGACGGACTATCGGCATCCGGTGCTCCGTATGCATGAATCTTATC CGGA TACTTTACAAAAGGCCGGTCACGACCTATTATATGTTTGGCGGCGTATGTAATCCCCACT GCTT CAATCACACTGGTTCCTATGTAAATGGCATCTTTCAGCATCGGCTGGTCTTTCTTTATCA ATGC ATAGAGTCCCATGGCTGTAGGTATTCCTACGGGTAGAATCACTCCGCTAGCGGACAATCC GCGG CTCAGTCCGTGTACATCCCATCGGTTGATGGTTTTCAACGTGTTGATGTCTATATTCTGT GCGC TGAGGCTGAATGTAAAACAGGCTGTCAGTATAAGAAAAATAATCCTTTGGCGTTTCATTT AGTT TGGCATTTGTTCAGTGCAAAGATAGGAAAATAATGTAATTCGCATTTACCCTTCCCCGAA TTAA AGAATAATTTCCATAATTCCTTGTATTATCGCTAGAATTCCTTTACTTTTGCATCGTGAA TACA CAGCTTTTAACAGAATTTTTAGTTCTAACAATTAAATAATTTAAATTCAATCATTTATGT GGTT AAGTAATTCATCTATTGGAAGGAAAGTGGTGATGAGTGTCACAGGTATCGCCCTTGTCCT GTTT CTGACGTTTCACATGGCGATGAACCTTGTTGCGCTCTTCTCGGAAGATGCTTACAACATG ATTT GTGAATTCTTGGGAGCTAACTGGTACGCGTTGGTTGCAACTGCCGGGCTGGCTGCTCTGT TTGT AATTCACATCATCTACGCTTTCTGGTTGACCATGCAGAACCGTGCAGCTCGCGGTAGCGA ACGT TATGCAGTGAACGTTAAACCTAAAACTGTGGAATGGGCATCTCAGAACATGCTTGTCCTG GGTA TTGTCGTTATTGCCGGATTGGCTCTTCATTTTGCCAATTTCTGGTACAAAATGCAGTTTG CCGA AATTATCGGTGTTCATGATTTGGGCGCATTCGGTCCTACAGACGGTGCCGCTTACATTCG TGAA ACATTCGGATGCCCTGTATTTACAGTGCTTTACCTCATTTGGTTAGCAGCTTTGTGGTTC CACC TGACTCACGGATTCTGGAGTGCTTTGCAGACTTTGGGCTGGAGCAATAAAATCTGGTTCG AGCG TTGGAAGACTATTGGTAACATCTACTCTACTTTGGTAGTTCTTGGTTTTGCAGCAGTAGT CGTT ATCTACTTCGCTATGACTGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGT TTCA TCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCA GGAT TCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGG GTGG GCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACG AACC CTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATA ATGA CCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCGGGGATTGGTGAACAAA AAGG TGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGATATTGAGGTATCATTTT ATCG TAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAAATTTTAGCATTTTGTA AAAA AGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTTGCATCCCGAAGAGTTT CTCT TAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTTTATGTCGTAAAGAGGG GCTT TGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTAGTTGAAACACATAGAA AGTT GCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTACGTTCTTTTCTCAAAA AACA TAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAATGAACAAAGTAAATAT AAAA GATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAATAATGAATTGCATAAGT TTAG ATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCATTTTACTGCTGGATTGG TAAA GAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTATGTGAGGTAACTCGTAA TAAG CTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACTGAAATTTACATTTCCT AGCC ACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGCACAAATATAATTCGAA AAAT TGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAATATGGTTTTGCTAAAAT GTTA TTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGTAGATATTTCTATATTA GCAA AAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGCACATTAATTGTATTAA AAAG AAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAACTTTTGTAATGAAATG GGTT AACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAAAGCTTTAAAACATGCG AGAA TATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTATTTAATAGTTATAAAA TATT TAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTACGCGGGTACCGACACCG CGGT GGAGGGGAATTGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCATC AAAT GAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTTCT GTAA TGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTGC GATT CCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATCA AGTG AGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCTT TCCA GACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAACC GTTA TTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGACAATTA CAAA CAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCTG AATC AGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAACCA TGCA TCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCAG TTTA GTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAACA ACTC TGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTATC GCGA GCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGGAGCAA GACG TTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAGTT TTAT TGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACAAC GTGG CTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGAGCCTACGTTCCGAATAC GGTC AAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAATTCTTTTA GGAA GCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGTTTGTGAT ACGC TCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATTTGATTCA AGTA CGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTACAGAACG GACA TCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAGCAAACGG GAAG TAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAAGAGCAGC AATA CCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACCTGATGGA AGAA ACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGATGATGCG GATA GGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACGCAATACT ACGT CCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCTTCGGCAA AGTT CAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGCTGAATCC CAGA CGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGTACCGAGT TCTA CAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTTTCAAACA TTTC TTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCATGCCGAC TTCT TTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGCTCCCTTC TTAC TTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAGGCTTCCA CCTC TTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCCGTTAAAC AAAA TTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACATCCGGTGA CAGC TCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAGTTCAAGT GAAA CTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAGCCCAATT GTAA AACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTACAGTCGCTCGGCGATC GAAG GCTTCGGAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAAT TCTT TTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGT TTGT GATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATT TGAT TCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTA CAGA ACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAG CAAA CGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAA GAGC AGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACC TGAT GGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGA TGAT GCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACG CAAT ACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCT TCGG CAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGC TGAA TCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGT ACCG AGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTT TCAA ACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCA TGCC GACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGC TCCC TTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAG GCTT CCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCC GTTA AACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACAT CCGG TGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAG TTCA AGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAG CCCA ATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTAGGATCAGCT GTAC GTACTCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCATGTTTCACGTACTAAGC TCTC ATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTCATGGCTAACGTACTAA GCTC TCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTGAACAATA AAAT TAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAAGA ATAT ATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACAAGCCAGGGATGTAACG CACT GAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGGAACACTTAACGGCTGA CATG GGGCGGCCGCGTAG [00243] SEQ ID NO: 87 (Plasmid encoding oxalate degradation pathway for genomic integration into Bacteroides vulgatus genome):

GGAGAGCTGTATGTGGGGTGGAAGAAGCTATCGTAAAAATGCTGGAGCAGCTTGATC CTCATTC TACCTATTCTGATCCGGAGGAAGTGAAGAGAATGAACGAGCCGTTGCAGGGAAACTTCGA AGGT ATCGGTATACAGTTTAATATGGCGGAGGACACTTTGCTGGTGATACAGCCTGTATCGGGC GGAC CGTCCGAAAAAGTCGGTATTCTGGCCGGTGATCGTATCGTCATGGTGGAAGATACGCTGA TAGC CGGTGTAAAGATGAGTACCGAGGATATTATGCGTCGCCTCCGTGGTCCTAAAGATTCAAA AGTG AATCTGAAAATACTTCGCCGAGGGGTGAAGGAACTGCTCCCCTTTACGGTGAAAAGGGAT AAAA TACCTGTTTACAGCTTGGATGCTTCCTATATGATTAAAGATAAGATCGGTTATATTCGTA TCAA CCGTTTTGCCGCCACTACCCATGAGGAGTTCAAGAAAGCGCTGACCGGGTTGCAGAAGAA AGGA ATGAAAGACTTGATTCTTGATTTGCAGGGCAATGGCGGGGGGTATTTGAATGCTGCTATC GATA TTGCCAATGAATTTTTGGGTAAAAAGGAACTGATTGTCTATACGGAGGGCCGTCGTAATC CTCG TAGCGAGTTTTTTGCCAAAGGTACGGGCGAGTTTCAGAACGGTCGTCTGATGGTATTGGT TGAT GAATTTTCGGCTTCTGCCAGTGAGATTGTGACCGGAGCTGTTCAGGATTGGGACAGAGGC GTTG TGGTAGGCCGTCGCAGTTTTGGTAAAGGCTTGGTGCAGCGTCCCATTGATTTGCCGGACG GTTC GATGATCCGTCTGACGGTGGCCCGCTATTATACGCCTGCCGGACGTTGTATCCAGAAACC TTAC GAGAGCATTGAAAAGTATAATGAAGACCTGATAGACCGTTATAATAAAGGAGAAATGATG AGTG AAGACAGCATCCACTTTCCGGATTCACTGAAGTTCAAGACTCATAGGTTGGCCCGTACGG TATA TGGTGGCGGAGGGATCATGCCCGATTATTTTGTGCCGATTGATACGACTCTCTATACTAA ATAC GTAAAGAATGGCTGGGCAAATACAAGACTTTCAATGAGTTCTACAAACGTTTTGAAGTGA CTCC GGATATGTTGACACAACTGGTTGCTACCGGCAAGGAGATGGGAGTGGAATATAATGAAGA AGAG TATCAAAAGGCCCTGCCTCTGCTGAGGTTGCAGATGAAAGCATTGATAGCCCGTGATTTA TGGG ATATGAATGAATATTATCACGTCATTAATGACGCGAATGAAAGTATCAGGAAAGCGCTGG AACT GTTGGAGCAACCGGACTTTGAGGGGCTGCTGTTGAAAAAGCGATAGTCAAGACTTTATAT TAAC TGCAGGGGCGCATAGTTGCACTCCTGCAGTTGTCTGAAAAACTTGTAGGATAAAACGAAA GGCT CAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGC AATG GTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTT GCAG TGTCGAAAGAAACAAAGTAGCCTGGCATCACCTAAAAATTATAAATAAATTAATAAACTT TTAT TAAAAAAAAATTACAAAATGAATAATCCACAAACAGGACAATCAACAGGCCTCTTGGGCA ATCG TTGGTTCTACTTGGTATTAGCAGTTTTGCTGATGTGTATGATCTCGGGTGTCCAATATTC CTGG ACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACG GCTT TCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATA AATT CGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCAT GGGT ATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGT ATCG TTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTT CCGG TTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGT TCTG AAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTTTGATCATGGGTATCCTGATT ATCC TGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTA CCGA CAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAATTCTGGGTTCTGTGGACCGC ATTC TTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGC CTCG GTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTT GCCG TCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTT CGGT ATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTT ATCG CCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCA ACAG CGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGC AACT GCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAACCAACTTCGGATGGAATACC GCTT TCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAA GAAT GGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAAGAAAAAGCTGTACATTAAGG TTCC TAACCTGCCTGGCATCTTAATCAATTTTAAACTCACCAAATCAAAATATGAAAAAAAAAA ATAA TAAAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGG CCCA TCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGC GTTG GTGACGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTTTACTTCACCA TGCT TAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAAT GGAA AAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCAC ATGG GCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAG GGTT TGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGG TGGC GCGGCATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGT GACA GCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAA CGGG GCGTGGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAA ATTA CGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAAT GGTA CATTTGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGA TCCT GAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTATTCAGGAGCA AAAC TGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCCGGCATACAGT ACAG CCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCA CTAT TGATAAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTT AAGT ATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAA CAAC CGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGG ATAT TAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAG CGAC GATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTAAACGACCTGGCAT CAAC TACCTTTATTATTCAACAAACCAATTTAACATATTAAAAAAATAAAAAAATGACTACCAC AGCA ACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCGGCATAGTA GGTA TTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTATACCGTGTC GCAA TGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAACCTGGTGT CCTG TTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATAGTATGTCG AACC GCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAAGGGAGGTT TCCA GGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAACTGACGCC GGAT AACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCGCCGGAGTG AGCT ATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAATGATAGAA CTGG TAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGTAAAATTAA GAAG GTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAGGTAAAGGA GCAG TGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTTCCTTCCGA CTCC CATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCCCGGAGCCA GGCT CTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCCTTCACTTC GGAA CGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCCGGAAACGC TCGG AGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGACTATCGGT TACT GCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAGTCAAACAG GAGA TCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAACGCGTGGAG CTCA GCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTATCGCACGAT CTTG GTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTGATGCACCT CGCA GAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGCATTAGCGT GTAA AGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTCGGTTTTAG CGCT ATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAATGAATAAC TCTG GGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTTGTCAAAAA ATTG TAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAATACCATCTC AGAG TTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAACCTCCGTC ATTA ATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAACAAGCCTA GACT GTAAGGTTCCTAATTCCCCTGGCATCAACTACCTAAATTACTTATCAAACCACTTAGTAG TAAA AAAAATATAACAAAATGACAAATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTA TCGA TATGACACATGTCCTTAATGGACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAG GGTA ATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACCCGCACATTTGGTCCCTATGTGGAT GGAC AGTCACTCTATTACAGTTTTATTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGA ATGA TCACGATAAAAGTATATTTATAAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTT TCGC CCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGC CTCA TATATGCTTCATCGTCAGGTTTCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACG ATAC CATCATTCAGGCAATGAGCGGGATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGT GCGC GTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGT GCAC TTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCA CGCT GAGTTTTCTGGAGCATGGTCTGATGGCATATATCGCAACTGGGAAGTCACCACAACGTCT GGGA AATCGCCATCCCTACATGGCACCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACG ATTT GTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGG TTAA TGATCCCCGATTTAGCAGCAATATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATA TATT GAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGT GTAC CCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAA ATAT GTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGC GGAC CCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAG TTCT CATCATAAGGTTCCTAAAATGCCTGGCATCTTTTCCATAACAAAAATTAAACCTCCTCCA TATG AAAAATAAAAATTATAAAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCAACGATACT TTTA GCGTATCCGATAATGTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGACCTACAGGG ATCT ATCCCACATGGTGGGTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCATTGTACGG AGCT GTTTTCAGACAAGATACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTATCGTCGCT TTCC TCGGTGCTACTATGGACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGG AGTT CAATTTTTATTTGAATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAA GTTA CAGAGTTCTGAAATTCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCC TTCG ATGCGACCAGGTTTAGGGTAGAGTATGATATATACTCTCCAGAGGACAACTACAAAAGGG TTAT TTACCGGTCTTTGAACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTCCCTGGGTT TGCC CGTTCCAGTGACGTTGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTCCAAAAACG GTGC CTTTGTTACATTTGAACATTGTGAGAAGCACGTTGAACATTGCTAACACTTACAAGCTAA CGCC CTTGGACAGATCTTATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTT ACTT TCCACTTTTAGAACTCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAAAGTTATTC TGGG ACCAATTTGTTAAGTACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAGCATGATTA TGCT GAACATGCCCAAACCAAACCCTTTCCCACACATTAGATTCATCAGATCGTGTTCTTCTGC TTTG GCTCCAGCAACGTTCCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGGAGGCCTAT GCGA TGACCGAAGCATCACATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTG GTAC TGTGGGCCAGCCACAAGGAGTCACCGTCGTCATTCTAGATGACAATGACAATGTCTTGCC CCCG GGCAAAGTCGGCGAAGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATGCTAATAAT CCAA AAGCTAACAAGGAGAACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGACCAAGGTT ATTT CGACCCTGAGGGGTTTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGG TGAA AAGATTTCACCCATTGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCGATGAAGCC GTTG CATTTGGTGTTCCCGACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGA AGGG AGAAAAAATGACCTACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAA AATT CCAACCAAGGTGTACTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAATCCAGAGA AGAG TTATCGCAGAAACTTTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGGTTCCTAAA AACC CTGGCATCTAAACTAAAATACAATAACCAAAAATCATTACAAATGAAAAAAAATAATAAA ATGG ATAGCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCCCGATCGCCGAG CTCT CTCCGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTAATCGAACGCGC CGCT TCACGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTCTCACCTTCCCT AACA CCGTCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCACGGCGGCGCCGT TGAA CGCAGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGATTCAAAGCTATT GTTA ACCTCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGAAAATCTCTCAC GTCA CCGCTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGATTCAGATTCCG TCGT TGACTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTCCTCCACACTTC TGGC ACTACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTTCATCCGTCAAG AACA TTAAAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCTCCCTCTGTTCC ATGT TCATGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCTGTAACTCTTCC AGCT GCTGGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATAACGCTACATGG TATA CTGCTGTGCCGACCATTCATCAGATCATATTGGACCGCCACGCGAGCCACCCTGAAACGG AATA TCCTAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTGATATTGTCCAG GCTT GAGGAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGGCAACACATTTG ATGA GCTCAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGGGAAACCGGTAG GTCA AGAAATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAACAAAGGAGAGGT TTGT ATAAGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCAACAAGGCAGGT TTCG AGTTTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGATACCGATGGGTATTTGCATC TGGT GGGTCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCAATTGAAGTGGA TGCA GTACTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTCCTGATGAGAAA TATG GGGAAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAACCGAAGAGGACA TTAA AGCGTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTGTTCATCACTGA TAAC CTCCCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAACATTTCCTTGAG AAGC CCTGAGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTCTGT TGTG TCTTCTTTTAGGTGTGGAATAATTTTCCAACCATCACTTTATCTGTCTCCCGAACAGCAC CTTA TTCAGCCATCGGTTCACATACACGTTCACGAAAGCACATCCTACTCCGATAGCGGCTCCT GCCA CTACATCACTGGGATAGTGCACCCCTTGGTTCATCCGGGCAAACCCTACTCCGCAAGCCC ATAC GGCTGAAGGGGCGATAACATACCACTTAGGATAAGTGATGGAGAGTGAGGTGGCTAAAGA AAAA GCTGCCGCAGTGTGTCCTGAAGGGAATGACGGACTATCGGCATCCGGTGCTCCGTATGCA TGAA TCTTATCCGGATACTTTACAAAAGGCCGGTCACGACCTATTATATGTTTGGCGGCGTATG TAAT CCCCACTGCTTCAATCACACTGGTTCCTATGTAAATGGCATCTTTCAGCATCGGCTGGTC TTTC TTTATCAATGCATAGAGTCCCATGGCTGTAGGTATTCCTACGGGTAGAATCACTCCGCTA GCGG ACAATCCGCGGCTCAGTCCGTGTACATCCCATCGGTTGATGGTTTTCAACGTGTTGATGT CTAT ATTCTGTGCGCTGAGGCTGAATGTAAAACAGGCTGTCAGTATAAGAAAAATAATCCTTTG GCGT TTCATTTAGTTTGGCATTTGTTCAGTGCAAAGATAGGAAAATAATGTAATTCGCATTTAC CCTT CCCCGAATTAAAGAATAATTTCCATAATTCCTTGTATTATCGCTAGAATTCCTTTACTTT TGCA TCGTGAATACACAGCTTTTAACAGAATTTTTAGTTCTAACAATTAAATAATTTAAATTCA ATCA TTTATGTGGTTAAGTAATTCATCTATTGGAAGGAAAGTGGTGATGAGTGTCACAGGTATC GCCC TTGTCCTGTTTCTGACGTTTCACATGGCGATGAACCTTGTTGCGCTCTTCTCGGAAGATG CTTA CAACATGATTTGTGAATTCTTGGGAGCTAACTGGTACGCGTTGGTTGCAACTGCCGGGCT GGCT GCTCTGTTTGTAATTCACATCATCTACGCTTTCTGGTTGACCATGCAGAACCGTGCAGCT CGCG GTAGCGAACGTTATGCAGTGAACGTTAAACCTAAAACTGTGGAATGGGCATCTCAGAACA TGCT TGTCCTGGGTATTGTCGTTATTGCCGGATTGGCTCTTCATTTTGCCAATTTCTGGTACAA AATG CAGTTTGCCGAAATTATCGGTGTTCATGATTTGGGCGCATTCGGTCCTACAGACGGTGCC GCTT ACATTCGTGAAACATTCGGATGCCCTGTATTTACAGTGCTTTACCTCATTTGGTTAGCAG CTTT GTGGTTCCACCTGACTCACGGATTCTGGAGTGCTTTGCAGACTTTGGGCTGGAGCAATAA AATC TGGTTCGAGCGTTGGAAGACTATTGGTAACATCTACTCTACTTTGGTAGTTCTTGGTTTT GCAG CAGTAGTCGTTATCTACTTCGCTATGACTGGCGCGCCTGATAGGTGGGCTGCCCTTCCTG GTTG GCTTGGTTTCATCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGC CTCG CAGAGCAGGATTCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACA CCCG CTCGCGGGTGGGCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGA AAGT CTACACGAACCCTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAA AAAT CGCTATAATGACCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCGGGGAT TGGT GAACAAAAAGGTGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGATATTGA GGTA TCATTTTATCGTAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAAATTTT AGCA TTTTGTAAAAAAGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTTGCATC CCGA AGAGTTTCTCTTAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTTTATGT CGTA AAGAGGGGCTTTGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTAGTTGA AACA CATAGAAAGTTGCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTACGTTC TTTT CTCAAAAAACATAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAATGAAC AAAG TAAATATAAAAGATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAATAATGA ATTG CATAAGTTTAGATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCATTTTAC TGCT GGATTGGTAAAGAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTATGTGAG GTAA CTCGTAATAAGCTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACTGAAAT TTAC ATTTCCTAGCCACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGCACAAA TATA ATTCGAAAAATTGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAATATGGT TTTG CTAAAATGTTATTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGTAGATA TTTC TATATTAGCAAAAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGCACATT AATT GTATTAAAAAGAAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAACTTTT GTAA TGAAATGGGTTAACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAAAGCTT TAAA ACATGCGAGAATATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTATTTAA TAGT TATAAAATATTTAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTACGCGGG TACC GACACCGCGGTGGAGGGGAATTGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACT CATC GAGCATCAAATGAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAA AAGC CGTTTCTGTAATGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGG TATC GGTCTGCGATTCCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAA TAAG GTTATCAAGTGAGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTT ATGC ATTTCTTTCCAGACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCA TCAA CCAAACCGTTATTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAA AAGG ACAATTACAAACAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAAT ATTT TCACCTGAATCAGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTG GTGA GTAACCATGCATCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATT CCGT CAGCCAGTTTAGTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATG TTTC AGAAACAACTCTGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGC CCGA CATTATCGCGAGCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCG GCCT GGAGCAAGACGTTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTA AGCA GACAGTTTTATTGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTT TGAG ACACAACGTGGCTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGAGCCTAC GTTC CGAATACGGTCAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTC GAAT TCTTTTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTC AGGT TTGTGATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATAC CATT TGATTCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTG TTTA CAGAACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGT TCAG CAAACGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGG CAAA GAGCAGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTC TACC TGATGGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGA CAGA TGATGCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTG TACG CAATACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATG ATCT TCGGCAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCA ATGC TGAATCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGC GTGT ACCGAGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTG ACTT TCAAACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGT CTCA TGCCGACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAA TGGC TCCCTTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTG TAAG GCTTCCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGG CCCC GTTAAACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGC ACAT CCGGTGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTG AAAG TTCAAGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAG GTAG CCCAATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTACAGTC GCTC GGCGATCGAAGGCTTCGGAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATG CCGC TTCGAATTCTTTTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTG ATAT TTCAGGTTTGTGATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTG TCTA TACCATTTGATTCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGC CGGT GTGTTTACAGAACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGC ACTT GGTTCAGCAAACGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATT TCTT TGGCAAAGAGCAGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACA GCGC TTCTACCTGATGGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACG TCCC GGACAGATGATGCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAA GTAT GTGTACGCAATACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTG CCGG ATGATCTTCGGCAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACC TTCG GCAATGCTGAATCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGC GGGT GGCGTGTACCGAGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGT TGTC CTGACTTTCAAACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTC ATTC AGTCTCATGCCGACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAG TCGT TAATGGCTCCCTTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGG AGGC GTGTAAGGCTTCCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTT TTAG CGGCCCCGTTAAACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACC GGAA AGCACATCCGGTGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACA TTAT TTGAAAGTTCAAGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAA AAAA AAGGTAGCCCAATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCC TAGG ATCAGCTGTACGTACTCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCATGTTTC ACGT ACTAAGCTCTCATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTCATGGC TAAC GTACTAAGCTCTCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATG TTTG AACAATAAAATTAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTTTATAA GAAA AAAAAGAATATATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACAAGCCA GGGA TGTAACGCACTGAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGGAACAC TTAA CGGCTGACATGGGGCGGCCGCGTAG [00244] SEQ ID NO: 88 (Plasmid encoding oxalate degradation pathway for genomic integration into Bacteroides vulgatus genome):

GGAGAGCTGTATGTGGGGTGGAAGAAGCTATCGTAAAAATGCTGGAGCAGCTTGATC CTCATTC TACCTATTCTGATCCGGAGGAAGTGAAGAGAATGAACGAGCCGTTGCAGGGAAACTTCGA AGGT ATCGGTATACAGTTTAATATGGCGGAGGACACTTTGCTGGTGATACAGCCTGTATCGGGC GGAC CGTCCGAAAAAGTCGGTATTCTGGCCGGTGATCGTATCGTCATGGTGGAAGATACGCTGA TAGC CGGTGTAAAGATGAGTACCGAGGATATTATGCGTCGCCTCCGTGGTCCTAAAGATTCAAA AGTG AATCTGAAAATACTTCGCCGAGGGGTGAAGGAACTGCTCCCCTTTACGGTGAAAAGGGAT AAAA TACCTGTTTACAGCTTGGATGCTTCCTATATGATTAAAGATAAGATCGGTTATATTCGTA TCAA CCGTTTTGCCGCCACTACCCATGAGGAGTTCAAGAAAGCGCTGACCGGGTTGCAGAAGAA AGGA ATGAAAGACTTGATTCTTGATTTGCAGGGCAATGGCGGGGGGTATTTGAATGCTGCTATC GATA TAGCGAGTTTTTTGCCAAAGGTACGGGCGAGTTTCAGAACGGTCGTCTGATGGTATTGGT TGAT GAATTTTCGGCTTCTGCCAGTGAGATTGTGACCGGAGCTGTTCAGGATTGGGACAGAGGC GTTG TGGTAGGCCGTCGCAGTTTTGGTAAAGGCTTGGTGCAGCGTCCCATTGATTTGCCGGACG GTTC GATGATCCGTCTGACGGTGGCCCGCTATTATACGCCTGCCGGACGTTGTATCCAGAAACC TTAC GAGAGCATTGAAAAGTATAATGAAGACCTGATAGACCGTTATAATAAAGGAGAAATGATG AGTG AAGACAGCATCCACTTTCCGGATTCACTGAAGTTCAAGACTCATAGGTTGGCCCGTACGG TATA TGGTGGCGGAGGGATCATGCCCGATTATTTTGTGCCGATTGATACGACTCTCTATACTAA ATAC CATCGTCAGTTGCGTGATAAAGGAGCATTGATGAAAGCTCATTTCCATTTTATTGATGCC CATC GTAAAGAATGGCTGGGCAAATACAAGACTTTCAATGAGTTCTACAAACGTTTTGAAGTGA CTCC GGATATGTTGACACAACTGGTTGCTACCGGCAAGGAGATGGGAGTGGAATATAATGAAGA AGAG TATCAAAAGGCCCTGCCTCTGCTGAGGTTGCAGATGAAAGCATTGATAGCCCGTGATTTA TGGG ATATGAATGAATATTATCACGTCATTAATGACGCGAATGAAAGTATCAGGAAAGCGCTGG AACT GTTGGAGCAACCGGACTTTGAGGGGCTGCTGTTGAAAAAGCGATAGTCAAGACTTTATAT TAAC TGCAGGGGCGCATAGTTGCACTCCTGCAGTTGTCTGAAAAACTTGTAGGATAAAACGAAA GGCT CAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGC AATG GTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTT GCAG TGTCGAAAGAAACAAAGTAGCCTGGCATCATCTACCTTCATTATTAATCATTCCAATTGT ATCA CTTAAAAATATAAAAAAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCG GTGT GCAATCTGGCCCATCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAAT TGAA CGTCCCGGCGTTGGTGACGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCG CTTT ACTTCACCATGCTTAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAG GCAA AGAGGTAATGGAAAAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGG GGCC ATTGATCACATGGGCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTT GGTT CGATCAAAGGGTTTGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTG CTCA GGCAGCGGGTGGCGCGGCATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGC TGCA GCGTTGGGTGACAGCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTG CATC GCGAAAAAACGGGGCGTGGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACC TTTG CCGCGTGAAATTACGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCC GCAG TATCCGAATGGTACATTTGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGT CAGC CTGGCTGGATCCTGAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCA CTAT TCAGGAGCAAAACTGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGA TCCG GCATACAGTACAGCCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAA AAAT ACACTGTCACTATTGATAAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTT GTGC ACCGGTTTTAAGTATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGT TGTT GAAGTGGAACAACCGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCT GCCT TTACGCCGGATATTAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGG AGCT GGGTTATAGCGACGATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTA ACCT GCCTGGCATCAACTACCTAAATTACTTATCAAACCACTTAGTAGTAAAAAAAATATAACA AAAT GACAAATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTATCGATATGACACATGT CCTT AATGGACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAGGGTAATTAAAGTTGAG CCGC CGGGTCATGGTGATGATACCCGCACATTTGGTCCCTATGTGGATGGACAGTCACTCTATT ACAG TTTTATTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGAATGATCACGATAAAAG TATA TTTATAAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTTTCGCCCAGGTACAATG GAAA AACTGGGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGCCTCATATATGCTTCAT CGTC AGGTTTCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACGATACCATCATTCAGGC AATG AGCGGGATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGTGCGCGTTGGTACATCT CTTG CGGATCTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGTGCACTTTATGGCCGCG AAAA GAGCCAGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCACGCTGAGTTTTCTGGA GCAT GGTCTGATGGCATATATCGCAACTGGGAAGTCACCACAACGTCTGGGAAATCGCCATCCC TACA TGGCACCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACGATTTGTTGTGGTAATG ACAA GCTTTTTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGGTTAATGATCCCCGATT TAGC AGCAATATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATATATTGAGCGGACGTTA AAAA CGCAGGCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGTGTACCCGTCGCGCCGT TATT AAGTGTGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAAATATGTTGATTGAAGC CGGG GGAATAATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGCGGACCCGCATGTTATG CCGG GAGCGGCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAGTTCTCATCATAAGGTT CCTA AACGACCTGGCATCATCTACCTTCATTATTAAACAAACCAAATTAATATCATAAAAAAAT AAAA AAATGACTACCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATA CTGT CTTCGGCATAGTAGGTATTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAAT TAAG TTTATACCGTGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATC TCGG ACAAACCTGGTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGA TCTA TAATAGTATGTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGA CATC CACAAGGGAGGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTC ACTG GTAAACTGACGCCGGATAACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTC AGGG AACCGCCGGAGTGAGCTATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCT TGAG GGCAATGATAGAACTGGTAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCA GACC CCAGTAAAATTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAA TAGT GATAGGTAAAGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAA CTTG CCGTTCCTTCCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTG AGCA GCGCCCGGAGCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGA ATTG GATCCTTCACTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGA CAGT AACCCGGAAACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGG GACA TCGGACTATCGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAAT ACTC GGGAGTCAAACAGGAGATCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAA GGAA AAAACGCGTGGAGCTCAGCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATT GACG ACTATCGCACGATCTTGGTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTT TTCC GACTGATGCACCTCGCAGAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTT AGGT TACGCATTAGCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGAC AGTG CCTTCGGTTTTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGA TTGT CGTAATGAATAACTCTGGGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCC GACC GCTTTGTCAAAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTC TTCG TCAATACCATCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCA AGCG CGAAACCTCCGTCATTAATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGC ATGG CAAAACAAGCCTAGACTGTAAGGTTCCTAAGGGTCCTGGCATCCCCAAAAAATTAATTCA TTTT CTCTTTTCCCTAACCCTTAAAATATAATAAAATGAGTAACGACGACAATGTAGAGTTGAC TGAT GGCTTTCATGTTTTGATCGATGCCCTGAAAATGAATGACATCGATACCATGTATGGTGTT GTCG GCATTCCTATCACGAACCTGGCTCGTATGTGGCAAGATGACGGTCAGCGTTTTTACAGCT TCCG TCACGAACAACACGCAGGTTATGCAGCTTCTATCGCCGGTTACATCGAAGGAAAACCTGG CGTT TGCTTGACCGTTTCCGCCCCTGGCTTCCTGAACGGCGTGACTTCCCTGGCTCATGCAACC ACCA ACTGCTTCCCAATGATCCTGTTGAGCGGTTCCAGTGAACGTGAAATCGTCGATTTGCAAC AGGG CGATTACGAAGAAATGGATCAGATGAATGTTGCACGTCCACACTGCAAAGCTTCTTTCCG TATC AACAGCATCAAAGACATTCCAATCGGTATCGCTCGTGCAGTTCGCACCGCTGTATCCGGA CGTC CAGGTGGTGTTTACGTTGACTTGCCAGCAAAACTGTTCGGTCAGACCATTTCTGTAGAAG AAGC TAACAAACTGCTCTTCAAACCAATCGATCCAGCTCCGGCACAGATTCCTGCTGAAGATGC TATC GCTCGCGCTGCTGACCTGATCAAGAACGCCAAACGTCCAGTTATCATGCTGGGTAAAGGC GCTG CATACGCACAATGCGACGACGAAATCCGCGCACTGGTTGAAGAAACCGGCATCCCATTCC TGCC AATGGGTATGGCTAAAGGCCTGCTGCCTGACAACCATCCACAATCCGCTGCTGCAACCCG TGCT TTCGCACTGGCACAGTGTGACGTTTGCGTACTGATCGGCGCTCGTCTGAACTGGCTGATG CAGC ACGGTAAAGGCAAAACCTGGGGCGACGAACTGAAGAAATACGTTCAGATCGACATCCAGG CTAA CGAAATGGACAGCAACCAGCCTATCGCTGCACCAGTTGTTGGTGACATCAAGTCCGCCGT TTCC CTGCTCCGCAAAGCACTGAAAGGCGCTCCAAAAGCTGACGCTGAATGGACCGGCGCTCTG AAAG CCAAAGTTGACGGCAACAAAGCCAAACTGGCTGGCAAGATGACTGCCGAAACCCCATCCG GAAT GATGAACTACTCCAATTCCCTGGGCGTTGTTCGTGACTTCATGCTGGCAAATCCGGATAT TTCC CTGGTTAACGAAGGCGCTAATGCACTCGACAACACTCGTATGATTGTTGACATGCTGAAA CCAC GCAAACGTCTTGACTCCGGTACCTGGGGTGTTATGGGTATTGGTATGGGCTACTGCGTTG CTGC AGCTGCTGTTACCGGCAAACCGGTTATCGCTGTTGAAGGCGATAGCGCATTCGGTTTCTC CGGT ATGGAACTGGAAACCATCTGCCGTTACAACCTGCCAGTTACCGTTATCATCATGAACAAT GGTG GTATCTATAAAGGTAACGAAGCAGATCCACAACCAGGCGTTATCTCCTGTACCCGTCTGA CCCG TGGTCGTTACGACATGATGATGGAAGCATTTGGCGGTAAAGGTTATGTTGCCAATACTCC AGCA GAACTGAAAGCTGCTCTGGAAGAAGCTGTTGCTTCCGGCAAACCATGCCTGATCAACGCG ATGA TCGATCCAGACGCTGGTGTCGAATCTGGCCGTATCAAGAGCCTGAACGTTGTAAGTAAAG TTGG CAAGAAATAAGGTTCCTAATTCCCCTGGCATCTAAACTAAAATACAATAACCAAAAATCA TACT ACATGTATAAAATTAAAAAAATGGATAGCGATACTCTCTCAGGATTATTGGAAAACGTCG CCAA AAAATTCCCCGATCGCCGAGCTCTCTCCGTTTCTGGAAAATTCAATCTCACTCACGCGCG TCTT CACGATCTAATCGAACGCGCCGCTTCACGCCTTGTCTCCGACGCTGGAATCAAACCCGGC GATG TCGTTGCTCTCACCTTCCCTAACACCGTCGAGTTTGTTATAATGTTTTTAGCGGTGATAA GAGC TAGAGCCACGGCGGCGCCGTTGAACGCAGCGTACACGGCGGAGGAATTTGAGTTTTACCT CTCC GATTCAGATTCAAAGCTATTGTTAACCTCTAAAGAAGGAAACGCACCGGCTCAAGAAGCA GCTT CAAAGCTGAAAATCTCTCACGTCACCGCTACGCTGCTTGACGCTGGCTCGGACCTTGTAC TATC CGTTGCGGATTCAGATTCCGTCGTTGACTCAGCGACGGAACTCGTTAATCACCCGGACGA CGGT GCTCTCTTCCTCCACACTTCTGGCACTACGAGCCGTCCAAAGGGTGTACCGCTTACGCAG CTCA ATCTAGCTTCATCCGTCAAGAACATTAAAGCTGTGTACAAGCTTACTGAGTCTGATTCTA CGGT GATTGTTCTCCCTCTGTTCCATGTTCATGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGG AGCT GGTGCTGCTGTAACTCTTCCAGCTGCTGGTAGATTCTCAGCAACAACATTTTGGCCAGAT ATGA AGAAGTATAACGCTACATGGTATACTGCTGTGCCGACCATTCATCAGATCATATTGGACC GCCA CGCGAGCCACCCTGAAACGGAATATCCTAAACTCCGGTTCATCAGGAGTTGCAGTGCTTC TTTG GCTCCGGTGATATTGTCCAGGCTTGAGGAAGCGTTTGGAGCACCGGTGCTCGAGGCCTAT GCAA TGACAGAGGCAACACATTTGATGAGCTCAAACCCCTTACCAGAGGAAGGTCCACACAAGC CTGG GTCTGTTGGGAAACCGGTAGGTCAAGAAATGGCGATCCTTAATGAGAAAGGCGAGATCCA AGAG CCAAATAACAAAGGAGAGGTTTGTATAAGAGGTCCAAATGTGACCAAGGGTTACAAGAAT AACC CAGAAGCCAACAAGGCAGGTTTCGAGTTTGGGTGGTTCCACACTGGTGATATCGGTTACT TTGA TACCGATGGGTATTTGCATCTGGTGGGTCGGATCAAAGAGCTTATTAACCGTGGAGGTGA GAAG ATATCTCCAATTGAAGTGGATGCAGTACTCTTAACGCATCCTGACGTTTCTCAGGGTGTT GCAT TCGGTGTTCCTGATGAGAAATATGGGGAAGAGATTAACTGTGCGGTGATTCCAAGAGAAG GAAC TACTGTAACCGAAGAGGACATTAAAGCGTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGT GCCA AAGAGAGTGTTCATCACTGATAACCTCCCCAAAACTGCCTCTGGTAAGATTCAGCGCCGT ATCG TCGCACAACATTTCCTTGAGAAGCCCTGAGGTTCCTAAAATGCCTGGCATCAACTACCTC AATT AATAATCAAACCATCTGAACAATGAATAAATTTAAAAAAATGACAAGTGCCGCTACTGTT ACTG CTTCGTTCAACGATACTTTTAGCGTATCCGATAATGTCGCCGTTATTGTTCCTGAAACGG ACAC TCAGGTGACCTACAGGGATCTATCCCACATGGTGGGTCACTTCCAGACCATGTTCACAAA TCCT AATTCTCCATTGTACGGAGCTGTTTTCAGACAAGATACAGTGGCGATATCCATGCGTAAT GGGC TGGAATTTATCGTCGCTTTCCTCGGTGCTACTATGGACGCTAAAATTGGCGCGCCCTTGA ATCC CAATTATAAGGAAAAGGAGTTCAATTTTTATTTGAATGACCTGAAATCTAAGGCGATTTG CGTC CCAAAGGGTACCACAAAGTTACAGAGTTCTGAAATTCTAAAATCTGCCTCCACGTTTGGA TGTT TTATCGTAGAGCTGGCCTTCGATGCGACCAGGTTTAGGGTAGAGTATGATATATACTCTC CAGA GGACAACTACAAAAGGGTTATTTACCGGTCTTTGAACAACGCCAAATTTGTCAACACAAA TCCC GTTAAATTCCCTGGGTTTGCCCGTTCCAGTGACGTTGCCCTGATTTTGCATACCAGTGGT ACCA CCTCCACTCCAAAAACGGTGCCTTTGTTACATTTGAACATTGTGAGAAGCACGTTGAACA TTGC TAACACTTACAAGCTAACGCCCTTGGACAGATCTTATGTCGTGATGCCTCTTTTCCACGT CCAT GGGTTAATTGGTGTTTTACTTTCCACTTTTAGAACTCAGGGTTCTGTTGTGGTTCCCGAT GGAT TCCATCCAAAGTTATTCTGGGACCAATTTGTTAAGTACAACTGTAATTGGTTCAGTTGCG TTCC CACAATAAGCATGATTATGCTGAACATGCCCAAACCAAACCCTTTCCCACACATTAGATT CATC AGATCGTGTTCTTCTGCTTTGGCTCCAGCAACGTTCCATAAGCTGGAGAAGGAATTCAAT GCAC CTGTCTTGGAGGCCTATGCGATGACCGAAGCATCACATCAAATGACCTCAAACAATCTGC CTCC AGGAAAGAGAAAGCCTGGTACTGTGGGCCAGCCACAAGGAGTCACCGTCGTCATTCTAGA TGAC AATGACAATGTCTTGCCCCCGGGCAAAGTCGGCGAAGTTTCCATCAGAGGCGAAAACGTC ACTT TGGGGTATGCTAATAATCCAAAAGCTAACAAGGAGAACTTCACCAAGAGAGAGAACTATT TCAG AACCGGTGACCAAGGTTATTTCGACCCTGAGGGGTTTTTGGTCCTTACAGGCAGAATCAA AGAG CTTATCAACAGGGGTGGTGAAAAGATTTCACCCATTGAGCTCGACGGCATTATGCTATCG CATC CAAAGATCGATGAAGCCGTTGCATTTGGTGTTCCCGACGATATGTACGGCCAAGTAGTTC AAGC CGCCATTGTTTTGAAGAAGGGAGAAAAAATGACCTACGAAGAACTGGTGAACTTCTTAAA GAAG CACCTAGCCTCTTTCAAAATTCCAACCAAGGTGTACTTTGTTGATAAGCTACCAAAAACC GCTA CAGGTAAAATCCAGAGAAGAGTTATCGCAGAAACTTTTGCTAAGAGCAGCAGAAATAAGA GTAA GTTGTAGGGTTCCTAAAAACCCTGGCATCACCTAAAAATTATAAATAAATTAATAAACTT TTAT TAAAAAAAAATTACAAAATGAATAATCCACAAACAGGACAATCAACAGGCCTCTTGGGCA ATCG TTGGTTCTACTTGGTATTAGCAGTTTTGCTGATGTGTATGATCTCGGGTGTCCAATATTC CTGG ACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACG GCTT TCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATA AATT CGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCAT GGGT ATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGT ATCG TTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTT CCGG TTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGT TCTG AAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTTTGATCATGGGTATCCTGATT ATCC TGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTA CCGA CAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAATTCTGGGTTCTGTGGACCGC ATTC TTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGC CTCG GTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTT GCCG TCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTT CGGT ATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTT ATCG CCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCA ACAG CGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGC AACT GCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAACCAACTTCGGATGGAATACC GCTT TCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAA GAAT GGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAAGAAAAAGCTGTACATTAAGG TTCC TAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTCTGTTGTGTCTTCTT TTAG GTGTGGAATAATTTTCCAACCATCACTTTATCTGTCTCCCGAACAGCACCTTATTCAGCC ATCG GTTCACATACACGTTCACGAAAGCACATCCTACTCCGATAGCGGCTCCTGCCACTACATC ACTG GGATAGTGCACCCCTTGGTTCATCCGGGCAAACCCTACTCCGCAAGCCCATACGGCTGAA GGGG CGATAACATACCACTTAGGATAAGTGATGGAGAGTGAGGTGGCTAAAGAAAAAGCTGCCG CAGT GTGTCCTGAAGGGAATGACGGACTATCGGCATCCGGTGCTCCGTATGCATGAATCTTATC CGGA TACTTTACAAAAGGCCGGTCACGACCTATTATATGTTTGGCGGCGTATGTAATCCCCACT GCTT CAATCACACTGGTTCCTATGTAAATGGCATCTTTCAGCATCGGCTGGTCTTTCTTTATCA ATGC ATAGAGTCCCATGGCTGTAGGTATTCCTACGGGTAGAATCACTCCGCTAGCGGACAATCC GCGG CTCAGTCCGTGTACATCCCATCGGTTGATGGTTTTCAACGTGTTGATGTCTATATTCTGT GCGC TGAGGCTGAATGTAAAACAGGCTGTCAGTATAAGAAAAATAATCCTTTGGCGTTTCATTT AGTT TGGCATTTGTTCAGTGCAAAGATAGGAAAATAATGTAATTCGCATTTACCCTTCCCCGAA TTAA AGAATAATTTCCATAATTCCTTGTATTATCGCTAGAATTCCTTTACTTTTGCATCGTGAA TACA CAGCTTTTAACAGAATTTTTAGTTCTAACAATTAAATAATTTAAATTCAATCATTTATGT GGTT AAGTAATTCATCTATTGGAAGGAAAGTGGTGATGAGTGTCACAGGTATCGCCCTTGTCCT GTTT CTGACGTTTCACATGGCGATGAACCTTGTTGCGCTCTTCTCGGAAGATGCTTACAACATG ATTT GTGAATTCTTGGGAGCTAACTGGTACGCGTTGGTTGCAACTGCCGGGCTGGCTGCTCTGT TTGT AATTCACATCATCTACGCTTTCTGGTTGACCATGCAGAACCGTGCAGCTCGCGGTAGCGA ACGT TATGCAGTGAACGTTAAACCTAAAACTGTGGAATGGGCATCTCAGAACATGCTTGTCCTG GGTA TTGTCGTTATTGCCGGATTGGCTCTTCATTTTGCCAATTTCTGGTACAAAATGCAGTTTG CCGA AATTATCGGTGTTCATGATTTGGGCGCATTCGGTCCTACAGACGGTGCCGCTTACATTCG TGAA ACATTCGGATGCCCTGTATTTACAGTGCTTTACCTCATTTGGTTAGCAGCTTTGTGGTTC CACC TGACTCACGGATTCTGGAGTGCTTTGCAGACTTTGGGCTGGAGCAATAAAATCTGGTTCG AGCG TTGGAAGACTATTGGTAACATCTACTCTACTTTGGTAGTTCTTGGTTTTGCAGCAGTAGT CGTT ATCTACTTCGCTATGACTGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGT TTCA TCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCA GGAT TCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGG GTGG GCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACG AACC CTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATA ATGA CCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCGGGGATTGGTGAACAAA AAGG TGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGATATTGAGGTATCATTTT ATCG TAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAAATTTTAGCATTTTGTA AAAA AGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTTGCATCCCGAAGAGTTT CTCT TAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTTTATGTCGTAAAGAGGG GCTT TGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTAGTTGAAACACATAGAA AGTT GCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTACGTTCTTTTCTCAAAA AACA TAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAATGAACAAAGTAAATAT AAAA GATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAATAATGAATTGCATAAGT TTAG ATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCATTTTACTGCTGGATTGG TAAA GAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTATGTGAGGTAACTCGTAA TAAG CTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACTGAAATTTACATTTCCT AGCC ACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGCACAAATATAATTCGAA AAAT TGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAATATGGTTTTGCTAAAAT GTTA TTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGTAGATATTTCTATATTA GCAA AAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGCACATTAATTGTATTAA AAAG AAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAACTTTTGTAATGAAATG GGTT AACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAAAGCTTTAAAACATGCG AGAA TATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTATTTAATAGTTATAAAA TATT TAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTACGCGGGTACCGACACCG CGGT GGAGGGGAATTGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCATC AAAT GAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTTCT GTAA TGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTGC GATT CCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATCA AGTG AGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCTT TCCA GACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAACC GTTA TTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGACAATTA CAAA CAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCTG AATC AGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAACCA TGCA TCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCAG TTTA GTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAACA ACTC TGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTATC GCGA GCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGGAGCAA GACG TTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAGTT TTAT TGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACAAC GTGG CTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGAGCCTACGTTCCGAATAC GGTC AAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAATTCTTTTA GGAA GCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGTTTGTGAT ACGC TCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATTTGATTCA AGTA CGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTACAGAACG GACA TCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAGCAAACGG GAAG TAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAAGAGCAGC AATA CCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACCTGATGGA AGAA ACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGATGATGCG GATA GGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACGCAATACT ACGT CCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCTTCGGCAA AGTT CAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGCTGAATCC CAGA CGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGTACCGAGT TCTA CAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTTTCAAACA TTTC TTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCATGCCGAC TTCT TTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGCTCCCTTC TTAC TTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAGGCTTCCA CCTC TTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCCGTTAAAC AAAA TTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACATCCGGTGA CAGC TCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAGTTCAAGT GAAA CTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAGCCCAATT GTAA AACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTACAGTCGCTCGGCGATC GAAG GCTTCGGAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAAT TCTT TTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGT TTGT GATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATT TGAT TCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTA CAGA ACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAG CAAA CGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAA GAGC AGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACC TGAT GGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGA TGAT GCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACG CAAT ACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCT TCGG CAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGC TGAA TCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGT ACCG AGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTT TCAA ACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCA TGCC GACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGC TCCC TTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAG GCTT CCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCC GTTA AACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACAT CCGG TGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAG TTCA AGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAG CCCA ATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTAGGATCAGCT GTAC GTACTCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCATGTTTCACGTACTAAGC TCTC ATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTCATGGCTAACGTACTAA GCTC TCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTGAACAATA AAAT TAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAAGA ATAT ATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACAAGCCAGGGATGTAACG CACT GAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGGAACACTTAACGGCTGA CATG GGGCGGCCGCGTAG [00245] SEQ ID NO: 89 (Plasmid encoding oxalate degradation pathway for genomic integration into Bacteroides vulgatus genome):

GGAGAGCTGTATGTGGGGTGGAAGAAGCTATCGTAAAAATGCTGGAGCAGCTTGATC CTCATTC TACCTATTCTGATCCGGAGGAAGTGAAGAGAATGAACGAGCCGTTGCAGGGAAACTTCGA AGGT ATCGGTATACAGTTTAATATGGCGGAGGACACTTTGCTGGTGATACAGCCTGTATCGGGC GGAC CGTCCGAAAAAGTCGGTATTCTGGCCGGTGATCGTATCGTCATGGTGGAAGATACGCTGA TAGC CGGTGTAAAGATGAGTACCGAGGATATTATGCGTCGCCTCCGTGGTCCTAAAGATTCAAA AGTG AATCTGAAAATACTTCGCCGAGGGGTGAAGGAACTGCTCCCCTTTACGGTGAAAAGGGAT AAAA TACCTGTTTACAGCTTGGATGCTTCCTATATGATTAAAGATAAGATCGGTTATATTCGTA TCAA CCGTTTTGCCGCCACTACCCATGAGGAGTTCAAGAAAGCGCTGACCGGGTTGCAGAAGAA AGGA ATGAAAGACTTGATTCTTGATTTGCAGGGCAATGGCGGGGGGTATTTGAATGCTGCTATC GATA TTGCCAATGAATTTTTGGGTAAAAAGGAACTGATTGTCTATACGGAGGGCCGTCGTAATC CTCG TAGCGAGTTTTTTGCCAAAGGTACGGGCGAGTTTCAGAACGGTCGTCTGATGGTATTGGT TGAT GAATTTTCGGCTTCTGCCAGTGAGATTGTGACCGGAGCTGTTCAGGATTGGGACAGAGGC GTTG TGGTAGGCCGTCGCAGTTTTGGTAAAGGCTTGGTGCAGCGTCCCATTGATTTGCCGGACG GTTC GATGATCCGTCTGACGGTGGCCCGCTATTATACGCCTGCCGGACGTTGTATCCAGAAACC TTAC GAGAGCATTGAAAAGTATAATGAAGACCTGATAGACCGTTATAATAAAGGAGAAATGATG AGTG AAGACAGCATCCACTTTCCGGATTCACTGAAGTTCAAGACTCATAGGTTGGCCCGTACGG TATA TGGTGGCGGAGGGATCATGCCCGATTATTTTGTGCCGATTGATACGACTCTCTATACTAA ATAC CATCGTCAGTTGCGTGATAAAGGAGCATTGATGAAAGCTCATTTCCATTTTATTGATGCC CATC GTAAAGAATGGCTGGGCAAATACAAGACTTTCAATGAGTTCTACAAACGTTTTGAAGTGA CTCC TATCAAAAGGCCCTGCCTCTGCTGAGGTTGCAGATGAAAGCATTGATAGCCCGTGATTTA TGGG ATATGAATGAATATTATCACGTCATTAATGACGCGAATGAAAGTATCAGGAAAGCGCTGG AACT GTTGGAGCAACCGGACTTTGAGGGGCTGCTGTTGAAAAAGCGATAGTCAAGACTTTATAT TAAC TGCAGGGGCGCATAGTTGCACTCCTGCAGTTGTCTGAAAAACTTGTAGGATAAAACGAAA GGCT CAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGC AATG GTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTT GCAG TGTCGAAAGAAACAAAGTAGCCTGGCATCATCTACCTTCATTATTAATCATTCCAATTGT ATCA CTTAAAAATATAAAAAAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCG GTGT GCAATCTGGCCCATCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAAT TGAA CGTCCCGGCGTTGGTGACGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCG CTTT ACTTCACCATGCTTAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAG GCAA AGAGGTAATGGAAAAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGG GGCC ATTGATCACATGGGCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTT GGTT CGATCAAAGGGTTTGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTG CTCA GGCAGCGGGTGGCGCGGCATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGC TGCA GCGTTGGGTGACAGCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTG CATC GCGAAAAAACGGGGCGTGGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACC TTTG CCGCGTGAAATTACGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCC GCAG TATCCGAATGGTACATTTGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGT CAGC CTGGCTGGATCCTGAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCA CTAT TCAGGAGCAAAACTGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGA TCCG GCATACAGTACAGCCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAA AAAT ACACTGTCACTATTGATAAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTT GTGC ACCGGTTTTAAGTATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGT TGTT GAAGTGGAACAACCGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCT GCCT TTACGCCGGATATTAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGG AGCT GGGTTATAGCGACGATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTA ACCT GCCTGGCATCTACCCCTAACAACCCATAAATTTAACTTTAAAAAATTTTTAAATATAATA AAAT GACTACCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGT CTTC GGCATAGTAGGTATTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAG TTTA TACCGTGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGG ACAA ACCTGGTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTA TAAT AGTATGTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATC CACA AGGGAGGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTG GTAA ACTGACGCCGGATAACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGG AACC GCCGGAGTGAGCTATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAG GGCA ATGATAGAACTGGTAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACC CCAG TAAAATTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGT GATA GGTAAAGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTG CCGT TCCTTCCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCA GCGC CCGGAGCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTG GATC CTTCACTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGT AACC CGGAAACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACA TCGG ACTATCGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTC GGGA GTCAAACAGGAGATCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAA AAAA CGCGTGGAGCTCAGCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACG ACTA TCGCACGATCTTGGTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCC GACT GATGCACCTCGCAGAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGT TACG CATTAGCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTG CCTT CGGTTTTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGT CGTA ATGAATAACTCTGGGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACC GCTT TGTCAAAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCG TCAA TACCATCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCG CGAA ACCTCCGTCATTAATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGG CAAA ACAAGCCTAGACTGTAAGGTTCCTAAACGACCTGGCATCATCTACCTATATTACTAAACA AACC AATTATAATAATTTTAAAAATAAAAAAATGACAAATAATGAAAGCAAAGGGCCGTTTGAA GGCT TATTAGTTATCGATATGACACATGTCCTTAATGGACCTTTCGGAACTCAACTTCTTTGTA ATAT GGGCGCAAGGGTAATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACCCGCACATTTGG TCCC TATGTGGATGGACAGTCACTCTATTACAGTTTTATTAATCATGGCAAAGAGAGTGTGGTT CTTG ATTTAAAGAATGATCACGATAAAAGTATATTTATAAATATGCTCAAACAAGCTGATGTAT TAGC TGAGAATTTTCGCCCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAAACGCTTCAAGA AATC AACCCGCGCCTCATATATGCTTCATCGTCAGGTTTCGGACATACCGGTCCGCTAAAAGAT GCTC CTGCCTACGATACCATCATTCAGGCAATGAGCGGGATAATGATGGAAACAGGATATCCTG ATGC TCCGCCAGTGCGCGTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTCTATTTATTCAG CGGA ATAGTGAGTGCACTTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATGTCGATATAGCG ATGT TTGATGCCACGCTGAGTTTTCTGGAGCATGGTCTGATGGCATATATCGCAACTGGGAAGT CACC ACAACGTCTGGGAAATCGCCATCCCTACATGGCACCTTTTGATGTTTTCAATACTCAGGA TAAG CCGATTACGATTTGTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCCAGGCACTGGAG CTTA CGGAACTGGTTAATGATCCCCGATTTAGCAGCAATATTTTACGCGTACAAAACCAGGCTA TTCT TAAACAATATATTGAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGGTTAGCCAGAAT ACAT GAAGTTGGTGTACCCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTAAATTGCCACAA ACTC AGGCGAGAAATATGTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAATCCGATAAAAA TCAG CGGCTGCGCGGACCCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAGCATGGGGAACA AATT CGCCAGGAGTTCTCATCATAAGGTTCCTAAGGGTCCTGGCATCTAAACTAAAATACAATA ACCA AAAATCATCTATGCGTAAAAAAAATTATAAAATGGATAGCGATACTCTCTCAGGATTATT GGAA AACGTCGCCAAAAAATTCCCCGATCGCCGAGCTCTCTCCGTTTCTGGAAAATTCAATCTC ACTC ACGCGCGTCTTCACGATCTAATCGAACGCGCCGCTTCACGCCTTGTCTCCGACGCTGGAA TCAA ACCCGGCGATGTCGTTGCTCTCACCTTCCCTAACACCGTCGAGTTTGTTATAATGTTTTT AGCG GTGATAAGAGCTAGAGCCACGGCGGCGCCGTTGAACGCAGCGTACACGGCGGAGGAATTT GAGT TTTACCTCTCCGATTCAGATTCAAAGCTATTGTTAACCTCTAAAGAAGGAAACGCACCGG CTCA AGAAGCAGCTTCAAAGCTGAAAATCTCTCACGTCACCGCTACGCTGCTTGACGCTGGCTC GGAC CTTGTACTATCCGTTGCGGATTCAGATTCCGTCGTTGACTCAGCGACGGAACTCGTTAAT CACC CGGACGACGGTGCTCTCTTCCTCCACACTTCTGGCACTACGAGCCGTCCAAAGGGTGTAC CGCT TACGCAGCTCAATCTAGCTTCATCCGTCAAGAACATTAAAGCTGTGTACAAGCTTACTGA GTCT GATTCTACGGTGATTGTTCTCCCTCTGTTCCATGTTCATGGATTGTTAGCTGGGTTGCTT AGCT CGCTTGGAGCTGGTGCTGCTGTAACTCTTCCAGCTGCTGGTAGATTCTCAGCAACAACAT TTTG GCCAGATATGAAGAAGTATAACGCTACATGGTATACTGCTGTGCCGACCATTCATCAGAT CATA TTGGACCGCCACGCGAGCCACCCTGAAACGGAATATCCTAAACTCCGGTTCATCAGGAGT TGCA GTGCTTCTTTGGCTCCGGTGATATTGTCCAGGCTTGAGGAAGCGTTTGGAGCACCGGTGC TCGA GGCCTATGCAATGACAGAGGCAACACATTTGATGAGCTCAAACCCCTTACCAGAGGAAGG TCCA CACAAGCCTGGGTCTGTTGGGAAACCGGTAGGTCAAGAAATGGCGATCCTTAATGAGAAA GGCG AGATCCAAGAGCCAAATAACAAAGGAGAGGTTTGTATAAGAGGTCCAAATGTGACCAAGG GTTA CAAGAATAACCCAGAAGCCAACAAGGCAGGTTTCGAGTTTGGGTGGTTCCACACTGGTGA TATC GGTTACTTTGATACCGATGGGTATTTGCATCTGGTGGGTCGGATCAAAGAGCTTATTAAC CGTG GAGGTGAGAAGATATCTCCAATTGAAGTGGATGCAGTACTCTTAACGCATCCTGACGTTT CTCA GGGTGTTGCATTCGGTGTTCCTGATGAGAAATATGGGGAAGAGATTAACTGTGCGGTGAT TCCA AGAGAAGGAACTACTGTAACCGAAGAGGACATTAAAGCGTTTTGTAAGAAGAATTTGGCA GCTT TCAAGGTGCCAAAGAGAGTGTTCATCACTGATAACCTCCCCAAAACTGCCTCTGGTAAGA TTCA GCGCCGTATCGTCGCACAACATTTCCTTGAGAAGCCCTGAGGTTCCTAATTCCCCTGGCA TCCC CAAAAAATTAATTCATTTTCTCTTTTCAACAATTTAAAAAAAATTAAAAAATGAGTAACG ACGA CAATGTAGAGTTGACTGATGGCTTTCATGTTTTGATCGATGCCCTGAAAATGAATGACAT CGAT ACCATGTATGGTGTTGTCGGCATTCCTATCACGAACCTGGCTCGTATGTGGCAAGATGAC GGTC AGCGTTTTTACAGCTTCCGTCACGAACAACACGCAGGTTATGCAGCTTCTATCGCCGGTT ACAT CGAAGGAAAACCTGGCGTTTGCTTGACCGTTTCCGCCCCTGGCTTCCTGAACGGCGTGAC TTCC CTGGCTCATGCAACCACCAACTGCTTCCCAATGATCCTGTTGAGCGGTTCCAGTGAACGT GAAA TCGTCGATTTGCAACAGGGCGATTACGAAGAAATGGATCAGATGAATGTTGCACGTCCAC ACTG CAAAGCTTCTTTCCGTATCAACAGCATCAAAGACATTCCAATCGGTATCGCTCGTGCAGT TCGC ACCGCTGTATCCGGACGTCCAGGTGGTGTTTACGTTGACTTGCCAGCAAAACTGTTCGGT CAGA CCATTTCTGTAGAAGAAGCTAACAAACTGCTCTTCAAACCAATCGATCCAGCTCCGGCAC AGAT TCCTGCTGAAGATGCTATCGCTCGCGCTGCTGACCTGATCAAGAACGCCAAACGTCCAGT TATC ATGCTGGGTAAAGGCGCTGCATACGCACAATGCGACGACGAAATCCGCGCACTGGTTGAA GAAA CCGGCATCCCATTCCTGCCAATGGGTATGGCTAAAGGCCTGCTGCCTGACAACCATCCAC AATC CGCTGCTGCAACCCGTGCTTTCGCACTGGCACAGTGTGACGTTTGCGTACTGATCGGCGC TCGT CTGAACTGGCTGATGCAGCACGGTAAAGGCAAAACCTGGGGCGACGAACTGAAGAAATAC GTTC AGATCGACATCCAGGCTAACGAAATGGACAGCAACCAGCCTATCGCTGCACCAGTTGTTG GTGA CATCAAGTCCGCCGTTTCCCTGCTCCGCAAAGCACTGAAAGGCGCTCCAAAAGCTGACGC TGAA TGGACCGGCGCTCTGAAAGCCAAAGTTGACGGCAACAAAGCCAAACTGGCTGGCAAGATG ACTG CCGAAACCCCATCCGGAATGATGAACTACTCCAATTCCCTGGGCGTTGTTCGTGACTTCA TGCT GGCAAATCCGGATATTTCCCTGGTTAACGAAGGCGCTAATGCACTCGACAACACTCGTAT GATT GTTGACATGCTGAAACCACGCAAACGTCTTGACTCCGGTACCTGGGGTGTTATGGGTATT GGTA TGGGCTACTGCGTTGCTGCAGCTGCTGTTACCGGCAAACCGGTTATCGCTGTTGAAGGCG ATAG CGCATTCGGTTTCTCCGGTATGGAACTGGAAACCATCTGCCGTTACAACCTGCCAGTTAC CGTT ATCATCATGAACAATGGTGGTATCTATAAAGGTAACGAAGCAGATCCACAACCAGGCGTT ATCT CCTGTACCCGTCTGACCCGTGGTCGTTACGACATGATGATGGAAGCATTTGGCGGTAAAG GTTA TGTTGCCAATACTCCAGCAGAACTGAAAGCTGCTCTGGAAGAAGCTGTTGCTTCCGGCAA ACCA TGCCTGATCAACGCGATGATCGATCCAGACGCTGGTGTCGAATCTGGCCGTATCAAGAGC CTGA ACGTTGTAAGTAAAGTTGGCAAGAAATAAGGTTCCTAAAATGCCTGGCATCAACTACCTC AATT AATAATCAAACCATCTGAACAATGAATAAATTTAAAAAAATGACAAGTGCCGCTACTGTT ACTG CTTCGTTCAACGATACTTTTAGCGTATCCGATAATGTCGCCGTTATTGTTCCTGAAACGG ACAC TCAGGTGACCTACAGGGATCTATCCCACATGGTGGGTCACTTCCAGACCATGTTCACAAA TCCT AATTCTCCATTGTACGGAGCTGTTTTCAGACAAGATACAGTGGCGATATCCATGCGTAAT GGGC TGGAATTTATCGTCGCTTTCCTCGGTGCTACTATGGACGCTAAAATTGGCGCGCCCTTGA ATCC CAATTATAAGGAAAAGGAGTTCAATTTTTATTTGAATGACCTGAAATCTAAGGCGATTTG CGTC CCAAAGGGTACCACAAAGTTACAGAGTTCTGAAATTCTAAAATCTGCCTCCACGTTTGGA TGTT TTATCGTAGAGCTGGCCTTCGATGCGACCAGGTTTAGGGTAGAGTATGATATATACTCTC CAGA GGACAACTACAAAAGGGTTATTTACCGGTCTTTGAACAACGCCAAATTTGTCAACACAAA TCCC GTTAAATTCCCTGGGTTTGCCCGTTCCAGTGACGTTGCCCTGATTTTGCATACCAGTGGT ACCA CCTCCACTCCAAAAACGGTGCCTTTGTTACATTTGAACATTGTGAGAAGCACGTTGAACA TTGC TAACACTTACAAGCTAACGCCCTTGGACAGATCTTATGTCGTGATGCCTCTTTTCCACGT CCAT GGGTTAATTGGTGTTTTACTTTCCACTTTTAGAACTCAGGGTTCTGTTGTGGTTCCCGAT GGAT TCCATCCAAAGTTATTCTGGGACCAATTTGTTAAGTACAACTGTAATTGGTTCAGTTGCG TTCC CACAATAAGCATGATTATGCTGAACATGCCCAAACCAAACCCTTTCCCACACATTAGATT CATC AGATCGTGTTCTTCTGCTTTGGCTCCAGCAACGTTCCATAAGCTGGAGAAGGAATTCAAT GCAC CTGTCTTGGAGGCCTATGCGATGACCGAAGCATCACATCAAATGACCTCAAACAATCTGC CTCC AGGAAAGAGAAAGCCTGGTACTGTGGGCCAGCCACAAGGAGTCACCGTCGTCATTCTAGA TGAC AATGACAATGTCTTGCCCCCGGGCAAAGTCGGCGAAGTTTCCATCAGAGGCGAAAACGTC ACTT TGGGGTATGCTAATAATCCAAAAGCTAACAAGGAGAACTTCACCAAGAGAGAGAACTATT TCAG AACCGGTGACCAAGGTTATTTCGACCCTGAGGGGTTTTTGGTCCTTACAGGCAGAATCAA AGAG CTTATCAACAGGGGTGGTGAAAAGATTTCACCCATTGAGCTCGACGGCATTATGCTATCG CATC CAAAGATCGATGAAGCCGTTGCATTTGGTGTTCCCGACGATATGTACGGCCAAGTAGTTC AAGC CGCCATTGTTTTGAAGAAGGGAGAAAAAATGACCTACGAAGAACTGGTGAACTTCTTAAA GAAG CACCTAGCCTCTTTCAAAATTCCAACCAAGGTGTACTTTGTTGATAAGCTACCAAAAACC GCTA CAGGTAAAATCCAGAGAAGAGTTATCGCAGAAACTTTTGCTAAGAGCAGCAGAAATAAGA GTAA GTTGTAGGGTTCCTAAAAACCCTGGCATCATCTACCTATATTATTCATCAAACCATTTGA TCCA ACATTAAATATTAAAAAATGAATAATCCACAAACAGGACAATCAACAGGCCTCTTGGGCA ATCG TTGGTTCTACTTGGTATTAGCAGTTTTGCTGATGTGTATGATCTCGGGTGTCCAATATTC CTGG ACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACG GCTT TCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATA AATT CGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCAT GGGT ATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGT ATCG TTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTT CCGG TTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGT TCTG AAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTTTGATCATGGGTATCCTGATT ATCC TGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTA CCGA CAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAATTCTGGGTTCTGTGGACCGC ATTC TTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGC CTCG GTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTT GCCG TCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTT CGGT ATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTT ATCG CCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCA ACAG CGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGC AACT GCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAACCAACTTCGGATGGAATACC GCTT TCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAA GAAT GGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAAGAAAAAGCTGTACATTAAGG TTCC TAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTCTGTTGTGTCTTCTT TTAG GTGTGGAATAATTTTCCAACCATCACTTTATCTGTCTCCCGAACAGCACCTTATTCAGCC ATCG GTTCACATACACGTTCACGAAAGCACATCCTACTCCGATAGCGGCTCCTGCCACTACATC ACTG GGATAGTGCACCCCTTGGTTCATCCGGGCAAACCCTACTCCGCAAGCCCATACGGCTGAA GGGG CGATAACATACCACTTAGGATAAGTGATGGAGAGTGAGGTGGCTAAAGAAAAAGCTGCCG CAGT GTGTCCTGAAGGGAATGACGGACTATCGGCATCCGGTGCTCCGTATGCATGAATCTTATC CGGA TACTTTACAAAAGGCCGGTCACGACCTATTATATGTTTGGCGGCGTATGTAATCCCCACT GCTT CAATCACACTGGTTCCTATGTAAATGGCATCTTTCAGCATCGGCTGGTCTTTCTTTATCA ATGC ATAGAGTCCCATGGCTGTAGGTATTCCTACGGGTAGAATCACTCCGCTAGCGGACAATCC GCGG CTCAGTCCGTGTACATCCCATCGGTTGATGGTTTTCAACGTGTTGATGTCTATATTCTGT GCGC TGAGGCTGAATGTAAAACAGGCTGTCAGTATAAGAAAAATAATCCTTTGGCGTTTCATTT AGTT TGGCATTTGTTCAGTGCAAAGATAGGAAAATAATGTAATTCGCATTTACCCTTCCCCGAA TTAA AGAATAATTTCCATAATTCCTTGTATTATCGCTAGAATTCCTTTACTTTTGCATCGTGAA TACA CAGCTTTTAACAGAATTTTTAGTTCTAACAATTAAATAATTTAAATTCAATCATTTATGT GGTT AAGTAATTCATCTATTGGAAGGAAAGTGGTGATGAGTGTCACAGGTATCGCCCTTGTCCT GTTT CTGACGTTTCACATGGCGATGAACCTTGTTGCGCTCTTCTCGGAAGATGCTTACAACATG ATTT GTGAATTCTTGGGAGCTAACTGGTACGCGTTGGTTGCAACTGCCGGGCTGGCTGCTCTGT TTGT AATTCACATCATCTACGCTTTCTGGTTGACCATGCAGAACCGTGCAGCTCGCGGTAGCGA ACGT TATGCAGTGAACGTTAAACCTAAAACTGTGGAATGGGCATCTCAGAACATGCTTGTCCTG GGTA TTGTCGTTATTGCCGGATTGGCTCTTCATTTTGCCAATTTCTGGTACAAAATGCAGTTTG CCGA AATTATCGGTGTTCATGATTTGGGCGCATTCGGTCCTACAGACGGTGCCGCTTACATTCG TGAA ACATTCGGATGCCCTGTATTTACAGTGCTTTACCTCATTTGGTTAGCAGCTTTGTGGTTC CACC TGACTCACGGATTCTGGAGTGCTTTGCAGACTTTGGGCTGGAGCAATAAAATCTGGTTCG AGCG TTGGAAGACTATTGGTAACATCTACTCTACTTTGGTAGTTCTTGGTTTTGCAGCAGTAGT CGTT ATCTACTTCGCTATGACTGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGT TTCA TCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCA GGAT TCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGG GTGG GCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACG AACC CTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATA ATGA CCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCGGGGATTGGTGAACAAA AAGG TGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGATATTGAGGTATCATTTT ATCG TAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAAATTTTAGCATTTTGTA AAAA AGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTTGCATCCCGAAGAGTTT CTCT TAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTTTATGTCGTAAAGAGGG GCTT TGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTAGTTGAAACACATAGAA AGTT GCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTACGTTCTTTTCTCAAAA AACA TAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAATGAACAAAGTAAATAT AAAA GATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAATAATGAATTGCATAAGT TTAG ATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCATTTTACTGCTGGATTGG TAAA GAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTATGTGAGGTAACTCGTAA TAAG CTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACTGAAATTTACATTTCCT AGCC ACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGCACAAATATAATTCGAA AAAT TGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAATATGGTTTTGCTAAAAT GTTA TTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGTAGATATTTCTATATTA GCAA AAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGCACATTAATTGTATTAA AAAG AAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAACTTTTGTAATGAAATG GGTT AACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAAAGCTTTAAAACATGCG AGAA TATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTATTTAATAGTTATAAAA TATT TAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTACGCGGGTACCGACACCG CGGT GGAGGGGAATTGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCATC AAAT GAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTTCT GTAA TGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTGC GATT CCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATCA AGTG AGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCTT TCCA GACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAACC GTTA TTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGACAATTA CAAA CAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCTG AATC AGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAACCA TGCA TCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCAG TTTA GTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAACA ACTC TGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTATC GCGA GCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGGAGCAA GACG TTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAGTT TTAT TGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACAAC GTGG CTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGAGCCTACGTTCCGAATAC GGTC AAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAATTCTTTTA GGAA GCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGTTTGTGAT ACGC TCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATTTGATTCA AGTA CGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTACAGAACG GACA TCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAGCAAACGG GAAG TAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAAGAGCAGC AATA CCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACCTGATGGA AGAA ACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGATGATGCG GATA GGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACGCAATACT ACGT CCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCTTCGGCAA AGTT CAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGCTGAATCC CAGA CGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGTACCGAGT TCTA CAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTTTCAAACA TTTC TTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCATGCCGAC TTCT TTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGCTCCCTTC TTAC TTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAGGCTTCCA CCTC TTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCCGTTAAAC AAAA TTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACATCCGGTGA CAGC TCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAGTTCAAGT GAAA CTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAGCCCAATT GTAA AACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTACAGTCGCTCGGCGATC GAAG GCTTCGGAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAAT TCTT TTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGT TTGT GATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATT TGAT TCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTA CAGA ACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAG CAAA CGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAA GAGC AGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACC TGAT GGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGA TGAT GCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACG CAAT ACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCT TCGG CAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGC TGAA TCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGT ACCG AGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTT TCAA ACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCA TGCC GACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGC TCCC TTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAG GCTT CCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCC GTTA AACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACAT CCGG TGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAG TTCA AGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAG CCCA ATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTAGGATCAGCT GTAC GTACTCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCATGTTTCACGTACTAAGC TCTC ATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTCATGGCTAACGTACTAA GCTC TCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTGAACAATA AAAT TAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAAGA ATAT ATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACAAGCCAGGGATGTAACG CACT GAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGGAACACTTAACGGCTGA CATG GGGCGGCCGCGTAG [00246] SEQ ID NO: 90 (Plasmid encoding oxalate degradation pathway for genomic integration into Bacteroides vulgatus genome):

GGAGAGCTGTATGTGGGGTGGAAGAAGCTATCGTAAAAATGCTGGAGCAGCTTGATC CTCATTC TACCTATTCTGATCCGGAGGAAGTGAAGAGAATGAACGAGCCGTTGCAGGGAAACTTCGA AGGT ATCGGTATACAGTTTAATATGGCGGAGGACACTTTGCTGGTGATACAGCCTGTATCGGGC GGAC CGTCCGAAAAAGTCGGTATTCTGGCCGGTGATCGTATCGTCATGGTGGAAGATACGCTGA TAGC CGGTGTAAAGATGAGTACCGAGGATATTATGCGTCGCCTCCGTGGTCCTAAAGATTCAAA AGTG AATCTGAAAATACTTCGCCGAGGGGTGAAGGAACTGCTCCCCTTTACGGTGAAAAGGGAT AAAA TACCTGTTTACAGCTTGGATGCTTCCTATATGATTAAAGATAAGATCGGTTATATTCGTA TCAA CCGTTTTGCCGCCACTACCCATGAGGAGTTCAAGAAAGCGCTGACCGGGTTGCAGAAGAA AGGA ATGAAAGACTTGATTCTTGATTTGCAGGGCAATGGCGGGGGGTATTTGAATGCTGCTATC GATA TTGCCAATGAATTTTTGGGTAAAAAGGAACTGATTGTCTATACGGAGGGCCGTCGTAATC CTCG TAGCGAGTTTTTTGCCAAAGGTACGGGCGAGTTTCAGAACGGTCGTCTGATGGTATTGGT TGAT GAATTTTCGGCTTCTGCCAGTGAGATTGTGACCGGAGCTGTTCAGGATTGGGACAGAGGC GTTG TGGTAGGCCGTCGCAGTTTTGGTAAAGGCTTGGTGCAGCGTCCCATTGATTTGCCGGACG GTTC GATGATCCGTCTGACGGTGGCCCGCTATTATACGCCTGCCGGACGTTGTATCCAGAAACC TTAC GAGAGCATTGAAAAGTATAATGAAGACCTGATAGACCGTTATAATAAAGGAGAAATGATG AGTG AAGACAGCATCCACTTTCCGGATTCACTGAAGTTCAAGACTCATAGGTTGGCCCGTACGG TATA TGGTGGCGGAGGGATCATGCCCGATTATTTTGTGCCGATTGATACGACTCTCTATACTAA ATAC CATCGTCAGTTGCGTGATAAAGGAGCATTGATGAAAGCTCATTTCCATTTTATTGATGCC CATC GTAAAGAATGGCTGGGCAAATACAAGACTTTCAATGAGTTCTACAAACGTTTTGAAGTGA CTCC GGATATGTTGACACAACTGGTTGCTACCGGCAAGGAGATGGGAGTGGAATATAATGAAGA AGAG TATCAAAAGGCCCTGCCTCTGCTGAGGTTGCAGATGAAAGCATTGATAGCCCGTGATTTA TGGG ATATGAATGAATATTATCACGTCATTAATGACGCGAATGAAAGTATCAGGAAAGCGCTGG AACT GTTGGAGCAACCGGACTTTGAGGGGCTGCTGTTGAAAAAGCGATAGTCAAGACTTTATAT TAAC TGCAGGGGCGCATAGTTGCACTCCTGCAGTTGTCTGAAAAACTTGTAGGATAAAACGAAA GGCT CAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGC AATG GTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTT GCAG TGTCGAAAGAAACAAAGTAGCCTGGCATCTTAATCAATTTTAAACTCACCAAATCAAAAT ATGA AAAAAAAAAATAATAAAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCG GTGT GCAATCTGGCCCATCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAAT TGAA ACTTCACCATGCTTAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAG GCAA AGAGGTAATGGAAAAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGG GGCC ATTGATCACATGGGCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTT GGTT CGATCAAAGGGTTTGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTG CTCA GGCAGCGGGTGGCGCGGCATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGC TGCA GCGTTGGGTGACAGCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTG CATC GCGAAAAAACGGGGCGTGGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACC TTTG CCGCGTGAAATTACGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCC GCAG TATCCGAATGGTACATTTGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGT CAGC CTGGCTGGATCCTGAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCA CTAT TCAGGAGCAAAACTGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGA TCCG GCATACAGTACAGCCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAA AAAT ACACTGTCACTATTGATAAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTT GTGC ACCGGTTTTAAGTATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGT TGTT GAAGTGGAACAACCGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCT GCCT TTACGCCGGATATTAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGG AGCT GGGTTATAGCGACGATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTA ACCT GCCTGGCATCAACTACCTAAATTAATTATCACCCCAAATTAATAACATAAAAATATAATA AAAT GAGTAACGACGACAATGTAGAGTTGACTGATGGCTTTCATGTTTTGATCGATGCCCTGAA AATG AATGACATCGATACCATGTATGGTGTTGTCGGCATTCCTATCACGAACCTGGCTCGTATG TGGC AAGATGACGGTCAGCGTTTTTACAGCTTCCGTCACGAACAACACGCAGGTTATGCAGCTT CTAT CGCCGGTTACATCGAAGGAAAACCTGGCGTTTGCTTGACCGTTTCCGCCCCTGGCTTCCT GAAC GGCGTGACTTCCCTGGCTCATGCAACCACCAACTGCTTCCCAATGATCCTGTTGAGCGGT TCCA GTGAACGTGAAATCGTCGATTTGCAACAGGGCGATTACGAAGAAATGGATCAGATGAATG TTGC ACGTCCACACTGCAAAGCTTCTTTCCGTATCAACAGCATCAAAGACATTCCAATCGGTAT CGCT CGTGCAGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTGTTTACGTTGACTTGCCAGCA AAAC TGTTCGGTCAGACCATTTCTGTAGAAGAAGCTAACAAACTGCTCTTCAAACCAATCGATC CAGC TCCGGCACAGATTCCTGCTGAAGATGCTATCGCTCGCGCTGCTGACCTGATCAAGAACGC CAAA CGTCCAGTTATCATGCTGGGTAAAGGCGCTGCATACGCACAATGCGACGACGAAATCCGC GCAC TGGTTGAAGAAACCGGCATCCCATTCCTGCCAATGGGTATGGCTAAAGGCCTGCTGCCTG ACAA CCATCCACAATCCGCTGCTGCAACCCGTGCTTTCGCACTGGCACAGTGTGACGTTTGCGT ACTG ATCGGCGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAGGCAAAACCTGGGGCGACGAA CTGA AGAAATACGTTCAGATCGACATCCAGGCTAACGAAATGGACAGCAACCAGCCTATCGCTG CACC AGTTGTTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGCAAAGCACTGAAAGGCGCTCC AAAA GCTGACGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTGACGGCAACAAAGCCAAACTG GCTG GCAAGATGACTGCCGAAACCCCATCCGGAATGATGAACTACTCCAATTCCCTGGGCGTTG TTCG TGACTTCATGCTGGCAAATCCGGATATTTCCCTGGTTAACGAAGGCGCTAATGCACTCGA CAAC ACTCGTATGATTGTTGACATGCTGAAACCACGCAAACGTCTTGACTCCGGTACCTGGGGT GTTA TGGGTATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGTTACCGGCAAACCGGTTATCG CTGT TGAAGGCGATAGCGCATTCGGTTTCTCCGGTATGGAACTGGAAACCATCTGCCGTTACAA CCTG CCAGTTACCGTTATCATCATGAACAATGGTGGTATCTATAAAGGTAACGAAGCAGATCCA CAAC CAGGCGTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTACGACATGATGATGGAAGCAT TTGG CGGTAAAGGTTATGTTGCCAATACTCCAGCAGAACTGAAAGCTGCTCTGGAAGAAGCTGT TGCT TCCGGCAAACCATGCCTGATCAACGCGATGATCGATCCAGACGCTGGTGTCGAATCTGGC CGTA TCAAGAGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAATAAGGTTCCTAAACGACCTGGC ATCA ACTACCTACATTAATAACCAACCCAAATGCCTAATCAATAAATATTATAAAATGAATAAT CCAC AAACAGGACAATCAACAGGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAGCAGTTT TGCT GATGTGTATGATCTCGGGTGTCCAATATTCCTGGACACTGTACGCTAACCCGGTTAAAGA CAAC CTTGGCGTTTCTTTGGCTGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATTCAAGCT GGTT CTCAGCCTGGTGGTGGTTACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGATGTTCG GTGG TGCGATGGTTCTCGCTGGCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGCTCTGTA TGCT CTTTATACTCTGGCCGGTGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAACACGGCT AACA GATGGTTCCCGGACAAACGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACGGTCTGG GTGT TCTGCCGTTCCTGCCACTGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGCAGCATT CATG TACACCGGTTTGATCATGGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGTTTCCCT GGCC AGCAAGGCGCCAAAAAACAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCGAAATGC TGAG AACACCACAATTCTGGGTTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGGTTTGCT GCTG GTTGCCAACAGCGTCCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTGACGATC GGTG TTTCGATCCAGAACCTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTTCCGATA AAAT CGGCCGTTACAAAACCATGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGCACTTTT CCCG ACGATTGCTGCCTTGGGCGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTCTTCACA TGGG GTGGTAGCTACGCTCTGTTCCCATCGACCAACAGCGATATTTTCGGTACGGCATACTCTG CCAG AAACTATGGTTTCTTCTGGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGGTCTGGG TGCT GCAATTGCAACCAACTTCGGATGGAATACCGCTTTCCTGATTACTGCGATTACTTCTTTC ATCG CATTTGCTCTGGCTACCTTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAATGGTCA AATT GTCTCCAGAAGAAAAAGCTGTACATTAAGGTTCCTAATTCCCCTGGCATCAACTACCTAA ATTA CTTATCAAACCACTTAGTAGTAAAAAAAATATAACAAAATGACAAATAATGAAAGCAAAG GGCC GTTTGAAGGCTTATTAGTTATCGATATGACACATGTCCTTAATGGACCTTTCGGAACTCA ACTT CTTTGTAATATGGGCGCAAGGGTAATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACC CGCA CATTTGGTCCCTATGTGGATGGACAGTCACTCTATTACAGTTTTATTAATCATGGCAAAG AGAG TGTGGTTCTTGATTTAAAGAATGATCACGATAAAAGTATATTTATAAATATGCTCAAACA AGCT GATGTATTAGCTGAGAATTTTCGCCCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAA ACGC TTCAAGAAATCAACCCGCGCCTCATATATGCTTCATCGTCAGGTTTCGGACATACCGGTC CGCT AAAAGATGCTCCTGCCTACGATACCATCATTCAGGCAATGAGCGGGATAATGATGGAAAC AGGA TATCCTGATGCTCCGCCAGTGCGCGTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTC TATT TATTCAGCGGAATAGTGAGTGCACTTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATG TCGA TATAGCGATGTTTGATGCCACGCTGAGTTTTCTGGAGCATGGTCTGATGGCATATATCGC AACT GGGAAGTCACCACAACGTCTGGGAAATCGCCATCCCTACATGGCACCTTTTGATGTTTTC AATA CTCAGGATAAGCCGATTACGATTTGTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCC AGGC ACTGGAGCTTACGGAACTGGTTAATGATCCCCGATTTAGCAGCAATATTTTACGCGTACA AAAC CAGGCTATTCTTAAACAATATATTGAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGG TTAG CCAGAATACATGAAGTTGGTGTACCCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTA AATT GCCACAAACTCAGGCGAGAAATATGTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAA TCCG ATAAAAATCAGCGGCTGCGCGGACCCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAG CATG GGGAACAAATTCGCCAGGAGTTCTCATCATAAGGTTCCTAAAAACCCTGGCATCTTTTCC ATAA CAAAAATTAAACCTCCTCCATATGAAAAATAAAAATTATAAAATGACAAGTGCCGCTACT GTTA CTGCTTCGTTCAACGATACTTTTAGCGTATCCGATAATGTCGCCGTTATTGTTCCTGAAA CGGA CACTCAGGTGACCTACAGGGATCTATCCCACATGGTGGGTCACTTCCAGACCATGTTCAC AAAT CCTAATTCTCCATTGTACGGAGCTGTTTTCAGACAAGATACAGTGGCGATATCCATGCGT AATG GGCTGGAATTTATCGTCGCTTTCCTCGGTGCTACTATGGACGCTAAAATTGGCGCGCCCT TGAA TCCCAATTATAAGGAAAAGGAGTTCAATTTTTATTTGAATGACCTGAAATCTAAGGCGAT TTGC GTCCCAAAGGGTACCACAAAGTTACAGAGTTCTGAAATTCTAAAATCTGCCTCCACGTTT GGAT GTTTTATCGTAGAGCTGGCCTTCGATGCGACCAGGTTTAGGGTAGAGTATGATATATACT CTCC AGAGGACAACTACAAAAGGGTTATTTACCGGTCTTTGAACAACGCCAAATTTGTCAACAC AAAT CCCGTTAAATTCCCTGGGTTTGCCCGTTCCAGTGACGTTGCCCTGATTTTGCATACCAGT GGTA CCACCTCCACTCCAAAAACGGTGCCTTTGTTACATTTGAACATTGTGAGAAGCACGTTGA ACAT TGCTAACACTTACAAGCTAACGCCCTTGGACAGATCTTATGTCGTGATGCCTCTTTTCCA CGTC CATGGGTTAATTGGTGTTTTACTTTCCACTTTTAGAACTCAGGGTTCTGTTGTGGTTCCC GATG GATTCCATCCAAAGTTATTCTGGGACCAATTTGTTAAGTACAACTGTAATTGGTTCAGTT GCGT TCCCACAATAAGCATGATTATGCTGAACATGCCCAAACCAAACCCTTTCCCACACATTAG ATTC ATCAGATCGTGTTCTTCTGCTTTGGCTCCAGCAACGTTCCATAAGCTGGAGAAGGAATTC AATG CACCTGTCTTGGAGGCCTATGCGATGACCGAAGCATCACATCAAATGACCTCAAACAATC TGCC TCCAGGAAAGAGAAAGCCTGGTACTGTGGGCCAGCCACAAGGAGTCACCGTCGTCATTCT AGAT GACAATGACAATGTCTTGCCCCCGGGCAAAGTCGGCGAAGTTTCCATCAGAGGCGAAAAC GTCA CTTTGGGGTATGCTAATAATCCAAAAGCTAACAAGGAGAACTTCACCAAGAGAGAGAACT ATTT CAGAACCGGTGACCAAGGTTATTTCGACCCTGAGGGGTTTTTGGTCCTTACAGGCAGAAT CAAA GAGCTTATCAACAGGGGTGGTGAAAAGATTTCACCCATTGAGCTCGACGGCATTATGCTA TCGC ATCCAAAGATCGATGAAGCCGTTGCATTTGGTGTTCCCGACGATATGTACGGCCAAGTAG TTCA AGCCGCCATTGTTTTGAAGAAGGGAGAAAAAATGACCTACGAAGAACTGGTGAACTTCTT AAAG AAGCACCTAGCCTCTTTCAAAATTCCAACCAAGGTGTACTTTGTTGATAAGCTACCAAAA ACCG CTACAGGTAAAATCCAGAGAAGAGTTATCGCAGAAACTTTTGCTAAGAGCAGCAGAAATA AGAG TAAGTTGTAGGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGAC TCTG TTGTGTCTTCTTTTAGGTGTGGAATAATTTTCCAACCATCACTTTATCTGTCTCCCGAAC AGCA CCTTATTCAGCCATCGGTTCACATACACGTTCACGAAAGCACATCCTACTCCGATAGCGG CTCC TGCCACTACATCACTGGGATAGTGCACCCCTTGGTTCATCCGGGCAAACCCTACTCCGCA AGCC CATACGGCTGAAGGGGCGATAACATACCACTTAGGATAAGTGATGGAGAGTGAGGTGGCT AAAG AAAAAGCTGCCGCAGTGTGTCCTGAAGGGAATGACGGACTATCGGCATCCGGTGCTCCGT ATGC ATGAATCTTATCCGGATACTTTACAAAAGGCCGGTCACGACCTATTATATGTTTGGCGGC GTAT GTAATCCCCACTGCTTCAATCACACTGGTTCCTATGTAAATGGCATCTTTCAGCATCGGC TGGT CTTTCTTTATCAATGCATAGAGTCCCATGGCTGTAGGTATTCCTACGGGTAGAATCACTC CGCT AGCGGACAATCCGCGGCTCAGTCCGTGTACATCCCATCGGTTGATGGTTTTCAACGTGTT GATG TCTATATTCTGTGCGCTGAGGCTGAATGTAAAACAGGCTGTCAGTATAAGAAAAATAATC CTTT GGCGTTTCATTTAGTTTGGCATTTGTTCAGTGCAAAGATAGGAAAATAATGTAATTCGCA TTTA CCCTTCCCCGAATTAAAGAATAATTTCCATAATTCCTTGTATTATCGCTAGAATTCCTTT ACTT TTGCATCGTGAATACACAGCTTTTAACAGAATTTTTAGTTCTAACAATTAAATAATTTAA ATTC AATCATTTATGTGGTTAAGTAATTCATCTATTGGAAGGAAAGTGGTGATGAGTGTCACAG GTAT CGCCCTTGTCCTGTTTCTGACGTTTCACATGGCGATGAACCTTGTTGCGCTCTTCTCGGA AGAT GCTTACAACATGATTTGTGAATTCTTGGGAGCTAACTGGTACGCGTTGGTTGCAACTGCC GGGC TGGCTGCTCTGTTTGTAATTCACATCATCTACGCTTTCTGGTTGACCATGCAGAACCGTG CAGC TCGCGGTAGCGAACGTTATGCAGTGAACGTTAAACCTAAAACTGTGGAATGGGCATCTCA GAAC ATGCTTGTCCTGGGTATTGTCGTTATTGCCGGATTGGCTCTTCATTTTGCCAATTTCTGG TACA AAATGCAGTTTGCCGAAATTATCGGTGTTCATGATTTGGGCGCATTCGGTCCTACAGACG GTGC CGCTTACATTCGTGAAACATTCGGATGCCCTGTATTTACAGTGCTTTACCTCATTTGGTT AGCA GCTTTGTGGTTCCACCTGACTCACGGATTCTGGAGTGCTTTGCAGACTTTGGGCTGGAGC AATA AAATCTGGTTCGAGCGTTGGAAGACTATTGGTAACATCTACTCTACTTTGGTAGTTCTTG GTTT TGCAGCAGTAGTCGTTATCTACTTCGCTATGACTGGCGCGCCTGATAGGTGGGCTGCCCT TCCT GGTTGGCTTGGTTTCATCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGG CCAG CCTCGCAGAGCAGGATTCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAG GAAC ACCCGCTCGCGGGTGGGCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACC AAGG AAAGTCTACACGAACCCTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATAC CGAA AAAATCGCTATAATGACCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCG GGGA TTGGTGAACAAAAAGGTGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGAT ATTG AGGTATCATTTTATCGTAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAA ATTT TAGCATTTTGTAAAAAAGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTT GCAT CCCGAAGAGTTTCTCTTAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTT TATG TCGTAAAGAGGGGCTTTGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTA GTTG AAACACATAGAAAGTTGCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTA CGTT CTTTTCTCAAAAAACATAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAA TGAA CAAAGTAAATATAAAAGATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAAT AATG AATTGCATAAGTTTAGATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCAT TTTA CTGCTGGATTGGTAAAGAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTAT GTGA GGTAACTCGTAATAAGCTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACT GAAA TTTACATTTCCTAGCCACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGC ACAA ATATAATTCGAAAAATTGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAAT ATGG TTTTGCTAAAATGTTATTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGT AGAT ATTTCTATATTAGCAAAAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGC ACAT TAATTGTATTAAAAAGAAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAA CTTT TGTAATGAAATGGGTTAACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAA AGCT TTAAAACATGCGAGAATATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTA TTTA ATAGTTATAAAATATTTAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTAC GCGG GTACCGACACCGCGGTGGAGGGGAATTGTGTTACAACCAATTAACCAATTCTGATTAGAA AAAC TCATCGAGCATCAAATGAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTT TGAA AAAGCCGTTTCTGTAATGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGAT CCTG GTATCGGTCTGCGATTCCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTC AAAA ATAAGGTTATCAAGTGAGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAA AGCT TATGCATTTCTTTCCAGACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCAC TCGC ATCAACCAAACCGTTATTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCT GTTA AAAGGACAATTACAAACAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCA ACAA TATTTTCACCTGAATCAGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCG CAGT GGTGAGTAACCATGCATCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCAT AAAT TCCGTCAGCCAGTTTAGTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTG CCAT GTTTCAGAAACAACTCTGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTG ATTG CCCGACATTATCGCGAGCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAA TCGC GGCCTGGAGCAAGACGTTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTT ATGT AAGCAGACAGTTTTATTGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGA GATT TTGAGACACAACGTGGCTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGAG CCTA CGTTCCGAATACGGTCAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCC GCTT CGAATTCTTTTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGAT ATTT CAGGTTTGTGATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTC TATA CCATTTGATTCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCG GTGT GTTTACAGAACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCAC TTGG TTCAGCAAACGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTC TTTG GCAAAGAGCAGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGC GCTT CTACCTGATGGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTC CCGG ACAGATGATGCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGT ATGT GTACGCAATACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCC GGAT GATCTTCGGCAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTT CGGC AATGCTGAATCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGG GTGG CGTGTACCGAGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTG TCCT GACTTTCAAACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCAT TCAG TCTCATGCCGACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTC GTTA ATGGCTCCCTTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAG GCGT GTAAGGCTTCCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTT AGCG GCCCCGTTAAACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGG AAAG CACATCCGGTGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATT ATTT GAAAGTTCAAGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAA AAAA GGTAGCCCAATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTA CAGT CGCTCGGCGATCGAAGGCTTCGGAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTA ATAT GCCGCTTCGAATTCTTTTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTC ACCT GATATTTCAGGTTTGTGATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTT TGCT GTCTATACCATTTGATTCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTAC CCAG CCGGTGTGTTTACAGAACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATT TCCG CACTTGGTTCAGCAAACGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGA ACAT TTCTTTGGCAAAGAGCAGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTAC ATAC AGCGCTTCTACCTGATGGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATAT ACAC GTCCCGGACAGATGATGCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAG AAGA AGTATGTGTACGCAATACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATC GCGT GCCGGATGATCTTCGGCAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCC GGAC CTTCGGCAATGCTGAATCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGG TGAG CGGGTGGCGTGTACCGAGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACA ATCG TTGTCCTGACTTTCAAACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTC AGTT CATTCAGTCTCATGCCGACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCA TTAA GTCGTTAATGGCTCCCTTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGC ATTG GAGGCGTGTAAGGCTTCCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAA TATT TTTAGCGGCCCCGTTAAACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATC AGAC CGGAAAGCACATCCGGTGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAA GAAC ATTATTTGAAAGTTCAAGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAA AACA AAAAAAAGGTAGCCCAATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTT TATC CTAGGATCAGCTGTACGTACTCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCAT GTTT CACGTACTAAGCTCTCATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTC ATGG CTAACGTACTAAGCTCTCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTC TCAT GTTTGAACAATAAAATTAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTT TATA AGAAAAAAAAGAATATATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACA AGCC AGGGATGTAACGCACTGAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGG AACA CTTAACGGCTGACATGGGGCGGCCGCGTAG [00247] SEQ ID NO: 91 (Plasmid encoding oxalate degradation pathway for genomic integration into Bacteroides vulgatus genome): TACCTATTCTGATCCGGAGGAAGTGAAGAGAATGAACGAGCCGTTGCAGGGAAACTTCGA AGGT ATCGGTATACAGTTTAATATGGCGGAGGACACTTTGCTGGTGATACAGCCTGTATCGGGC GGAC CGTCCGAAAAAGTCGGTATTCTGGCCGGTGATCGTATCGTCATGGTGGAAGATACGCTGA TAGC CGGTGTAAAGATGAGTACCGAGGATATTATGCGTCGCCTCCGTGGTCCTAAAGATTCAAA AGTG AATCTGAAAATACTTCGCCGAGGGGTGAAGGAACTGCTCCCCTTTACGGTGAAAAGGGAT AAAA TACCTGTTTACAGCTTGGATGCTTCCTATATGATTAAAGATAAGATCGGTTATATTCGTA TCAA CCGTTTTGCCGCCACTACCCATGAGGAGTTCAAGAAAGCGCTGACCGGGTTGCAGAAGAA AGGA ATGAAAGACTTGATTCTTGATTTGCAGGGCAATGGCGGGGGGTATTTGAATGCTGCTATC GATA TTGCCAATGAATTTTTGGGTAAAAAGGAACTGATTGTCTATACGGAGGGCCGTCGTAATC CTCG TAGCGAGTTTTTTGCCAAAGGTACGGGCGAGTTTCAGAACGGTCGTCTGATGGTATTGGT TGAT GAATTTTCGGCTTCTGCCAGTGAGATTGTGACCGGAGCTGTTCAGGATTGGGACAGAGGC GTTG TGGTAGGCCGTCGCAGTTTTGGTAAAGGCTTGGTGCAGCGTCCCATTGATTTGCCGGACG GTTC GATGATCCGTCTGACGGTGGCCCGCTATTATACGCCTGCCGGACGTTGTATCCAGAAACC TTAC GAGAGCATTGAAAAGTATAATGAAGACCTGATAGACCGTTATAATAAAGGAGAAATGATG AGTG AAGACAGCATCCACTTTCCGGATTCACTGAAGTTCAAGACTCATAGGTTGGCCCGTACGG TATA TGGTGGCGGAGGGATCATGCCCGATTATTTTGTGCCGATTGATACGACTCTCTATACTAA ATAC CATCGTCAGTTGCGTGATAAAGGAGCATTGATGAAAGCTCATTTCCATTTTATTGATGCC CATC GTAAAGAATGGCTGGGCAAATACAAGACTTTCAATGAGTTCTACAAACGTTTTGAAGTGA CTCC GGATATGTTGACACAACTGGTTGCTACCGGCAAGGAGATGGGAGTGGAATATAATGAAGA AGAG TATCAAAAGGCCCTGCCTCTGCTGAGGTTGCAGATGAAAGCATTGATAGCCCGTGATTTA TGGG ATATGAATGAATATTATCACGTCATTAATGACGCGAATGAAAGTATCAGGAAAGCGCTGG AACT GTTGGAGCAACCGGACTTTGAGGGGCTGCTGTTGAAAAAGCGATAGTCAAGACTTTATAT TAAC TGCAGGGGCGCATAGTTGCACTCCTGCAGTTGTCTGAAAAACTTGTAGGATAAAACGAAA GGCT CAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGC AATG GTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTT GCAG TGTCGAAAGAAACAAAGTAGCCTGGCATCACCTAAAAATTATAAATAAATTAATAAACTT TTAT TAAAAAAAAATTACAAAATGAATAATCCACAAACAGGACAATCAACAGGCCTCTTGGGCA ATCG TTGGTTCTACTTGGTATTAGCAGTTTTGCTGATGTGTATGATCTCGGGTGTCCAATATTC CTGG ACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACG GCTT TCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATA AATT CGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCAT GGGT ATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGT ATCG TTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTT CCGG TTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGT TCTG AAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTTTGATCATGGGTATCCTGATT ATCC TGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTA CCGA CAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAATTCTGGGTTCTGTGGACCGC ATTC TTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGC CTCG GTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTT GCCG TCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTT CGGT ATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTT ATCG CCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCA ACAG CGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGC AACT GCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAACCAACTTCGGATGGAATACC GCTT TCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAA GAAT GGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAAGAAAAAGCTGTACATTAAGG TTCC TAACCTGCCTGGCATCTTAATCAATTTTAAACTCACCAAATCAAAATATGAAAAAAAAAA ATAA TAAAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGG CCCA TCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGC GTTG GTGACGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTTTACTTCACCA TGCT TAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAAT GGAA AAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCAC ATGG GCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAG GGTT TGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGG TGGC GCGGCATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGT GACA GCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAA CGGG GCGTGGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAA ATTA CGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAAT GGTA CATTTGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGA TCCT GAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTATTCAGGAGCA AAAC TGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCCGGCATACAGT ACAG CCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCA CTAT TGATAAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTT AAGT ATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAA CAAC CGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGG ATAT TAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAG CGAC GATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTAAACGACCTGGCAT CAAC TACCTTTATTATTCAACAAACCAATTTAACATATTAAAAAAATAAAAAAATGACTACCAC AGCA ACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCGGCATAGTA GGTA TTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTATACCGTGTC GCAA TGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAACCTGGTGT CCTG TTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATAGTATGTCG AACC GCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAAGGGAGGTT TCCA GGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAACTGACGCC GGAT AACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCGCCGGAGTG AGCT ATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAATGATAGAA CTGG TAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGTAAAATTAA GAAG GTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAGGTAAAGGA GCAG TGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTTCCTTCCGA CTCC CATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCCCGGAGCCA GGCT CTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCCTTCACTTC GGAA CGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCCGGAAACGC TCGG AGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGACTATCGGT TACT GCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAGTCAAACAG GAGA TCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAACGCGTGGAG CTCA GCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTATCGCACGAT CTTG GTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTGATGCACCT CGCA GAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGCATTAGCGT GTAA AGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTCGGTTTTAG CGCT ATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAATGAATAAC TCTG GGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTTGTCAAAAA ATTG TAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAATACCATCTC AGAG TTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAACCTCCGTC ATTA ATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAACAAGCCTA GACT GTAAGGTTCCTAATTCCCCTGGCATCAACTACCTAAATTACTTATCAAACCACTTAGTAG TAAA AAAAATATAACAAAATGACAAATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTA TCGA TATGACACATGTCCTTAATGGACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAG GGTA ATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACCCGCACATTTGGTCCCTATGTGGAT GGAC AGTCACTCTATTACAGTTTTATTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGA ATGA TCACGATAAAAGTATATTTATAAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTT TCGC CCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGC CTCA TATATGCTTCATCGTCAGGTTTCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACG ATAC CATCATTCAGGCAATGAGCGGGATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGT GCGC GTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGT GCAC TTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCA CGCT GAGTTTTCTGGAGCATGGTCTGATGGCATATATCGCAACTGGGAAGTCACCACAACGTCT GGGA AATCGCCATCCCTACATGGCACCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACG ATTT GTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGG TTAA TGATCCCCGATTTAGCAGCAATATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATA TATT GAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGT GTAC CCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAA ATAT GTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGC GGAC CCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAG TTCT CATCATAAGGTTCCTAAAAACCCTGGCATCTTTTCCATAACAAAAATTAAACCTCCTCCA TATG AAAAATAAAAATTATAAAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCAACGATACT TTTA GCGTATCCGATAATGTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGACCTACAGGG ATCT ATCCCACATGGTGGGTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCATTGTACGG AGCT GTTTTCAGACAAGATACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTATCGTCGCT TTCC TCGGTGCTACTATGGACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGG AGTT CAATTTTTATTTGAATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAA GTTA CAGAGTTCTGAAATTCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCC TTCG ATGCGACCAGGTTTAGGGTAGAGTATGATATATACTCTCCAGAGGACAACTACAAAAGGG TTAT TTACCGGTCTTTGAACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTCCCTGGGTT TGCC CGTTCCAGTGACGTTGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTCCAAAAACG GTGC CTTTGTTACATTTGAACATTGTGAGAAGCACGTTGAACATTGCTAACACTTACAAGCTAA CGCC CTTGGACAGATCTTATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTT ACTT TCCACTTTTAGAACTCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAAAGTTATTC TGGG ACCAATTTGTTAAGTACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAGCATGATTA TGCT GAACATGCCCAAACCAAACCCTTTCCCACACATTAGATTCATCAGATCGTGTTCTTCTGC TTTG GCTCCAGCAACGTTCCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGGAGGCCTAT GCGA TGACCGAAGCATCACATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTG GTAC TGTGGGCCAGCCACAAGGAGTCACCGTCGTCATTCTAGATGACAATGACAATGTCTTGCC CCCG GGCAAAGTCGGCGAAGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATGCTAATAAT CCAA AAGCTAACAAGGAGAACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGACCAAGGTT ATTT CGACCCTGAGGGGTTTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGG TGAA AAGATTTCACCCATTGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCGATGAAGCC GTTG CATTTGGTGTTCCCGACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGA AGGG AGAAAAAATGACCTACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAA AATT CCAACCAAGGTGTACTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAATCCAGAGA AGAG TTATCGCAGAAACTTTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGGTTCCTAGC TGAT TAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTCTGTTGTGTCTTCTTTTAGGTGT GGAA TAATTTTCCAACCATCACTTTATCTGTCTCCCGAACAGCACCTTATTCAGCCATCGGTTC ACAT ACACGTTCACGAAAGCACATCCTACTCCGATAGCGGCTCCTGCCACTACATCACTGGGAT AGTG CACCCCTTGGTTCATCCGGGCAAACCCTACTCCGCAAGCCCATACGGCTGAAGGGGCGAT AACA TACCACTTAGGATAAGTGATGGAGAGTGAGGTGGCTAAAGAAAAAGCTGCCGCAGTGTGT CCTG AAGGGAATGACGGACTATCGGCATCCGGTGCTCCGTATGCATGAATCTTATCCGGATACT TTAC AAAAGGCCGGTCACGACCTATTATATGTTTGGCGGCGTATGTAATCCCCACTGCTTCAAT CACA CTGGTTCCTATGTAAATGGCATCTTTCAGCATCGGCTGGTCTTTCTTTATCAATGCATAG AGTC CCATGGCTGTAGGTATTCCTACGGGTAGAATCACTCCGCTAGCGGACAATCCGCGGCTCA GTCC GTGTACATCCCATCGGTTGATGGTTTTCAACGTGTTGATGTCTATATTCTGTGCGCTGAG GCTG AATGTAAAACAGGCTGTCAGTATAAGAAAAATAATCCTTTGGCGTTTCATTTAGTTTGGC ATTT GTTCAGTGCAAAGATAGGAAAATAATGTAATTCGCATTTACCCTTCCCCGAATTAAAGAA TAAT TTCCATAATTCCTTGTATTATCGCTAGAATTCCTTTACTTTTGCATCGTGAATACACAGC TTTT AACAGAATTTTTAGTTCTAACAATTAAATAATTTAAATTCAATCATTTATGTGGTTAAGT AATT CATCTATTGGAAGGAAAGTGGTGATGAGTGTCACAGGTATCGCCCTTGTCCTGTTTCTGA CGTT TCACATGGCGATGAACCTTGTTGCGCTCTTCTCGGAAGATGCTTACAACATGATTTGTGA ATTC TTGGGAGCTAACTGGTACGCGTTGGTTGCAACTGCCGGGCTGGCTGCTCTGTTTGTAATT CACA TCATCTACGCTTTCTGGTTGACCATGCAGAACCGTGCAGCTCGCGGTAGCGAACGTTATG CAGT GAACGTTAAACCTAAAACTGTGGAATGGGCATCTCAGAACATGCTTGTCCTGGGTATTGT CGTT ATTGCCGGATTGGCTCTTCATTTTGCCAATTTCTGGTACAAAATGCAGTTTGCCGAAATT ATCG GTGTTCATGATTTGGGCGCATTCGGTCCTACAGACGGTGCCGCTTACATTCGTGAAACAT TCGG ATGCCCTGTATTTACAGTGCTTTACCTCATTTGGTTAGCAGCTTTGTGGTTCCACCTGAC TCAC GGATTCTGGAGTGCTTTGCAGACTTTGGGCTGGAGCAATAAAATCTGGTTCGAGCGTTGG AAGA CTATTGGTAACATCTACTCTACTTTGGTAGTTCTTGGTTTTGCAGCAGTAGTCGTTATCT ACTT CGCTATGACTGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGTTTCATCAG CCAT CCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCAGGATTCCC GTTG AGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGGGTGGGCCT ACTT CACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACGAACCCTTT GGCA AAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATAATGACCCC GAAG CAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCGGGGATTGGTGAACAAAAAGGTGTT TCTC TCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGATATTGAGGTATCATTTTATCGTAAA AGAC ATTTTTGCTCAACAATTGCTTGACGGAAATCAACAAATTTTAGCATTTTGTAAAAAAGTC GCTA TATAATTTGGTGAATTGGAGTTATTTTCATATTTTTGCATCCCGAAGAGTTTCTCTTAAA GAGA GAAACATCTTTTGCATACCTTTTCCGACCGAATTTTTATGTCGTAAAGAGGGGCTTTGCA GGGG GTGGACTCAGAAAGATGAGAATAGATGACTATTGTAGTTGAAACACATAGAAAGTTGCTG ATAT ACAGACCGATACGCATATCGGGATGAACCATGAGTACGTTCTTTTCTCAAAAAACATAAA TATT CGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAATGAACAAAGTAAATATAAAAGATA GTCA AAATTTTATTACTTCAAAATATCACATAGAAAAAATAATGAATTGCATAAGTTTAGATGA AAAA GATAACATCTTTGAAATAGGTGCAGGGAAAGGTCATTTTACTGCTGGATTGGTAAAGAGA TGTA ATTTTGTAACGGCGATAGAAATTGATTCTAAATTATGTGAGGTAACTCGTAATAAGCTCT TAAA TTATCCTAACTATCAAATAGTAAATGATGATATACTGAAATTTACATTTCCTAGCCACAA TCCA TATAAAATATTTGGCAGCATACCTTACAACATAAGCACAAATATAATTCGAAAAATTGTT TTTG AAAGTTCAGCCACAATAAGTTATTTAATAGTGGAATATGGTTTTGCTAAAATGTTATTAG ATAC AAACAGATCACTAGCATTGCTGTTAATGGCAGAGGTAGATATTTCTATATTAGCAAAAAT TCCT AGGTATTATTTCCATCCAAAACCTAAAGTGGATAGCACATTAATTGTATTAAAAAGAAAG CCAG CAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAACTTTTGTAATGAAATGGGTTAACA AAGA GTACGAAAAACTGTTTACAAAAAATCAATTTAATAAAGCTTTAAAACATGCGAGAATATA TGAT ATAAACAATATTAGTTTCGAACAATTTGTATCGCTATTTAATAGTTATAAAATATTTAAC GGCT AAAAACAATAGGCCACATGCAACTGTAAATGTTTACGCGGGTACCGACACCGCGGTGGAG GGGA ATTGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCATCAAATGAAA CTGC AATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTTCTGTAATGAA GGAG AAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTGCGATTCCGA CTCG TCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATCAAGTGAGAA ATCA CCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCTTTCCAGACT TGTT CAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAACCGTTATTCA TTCG TGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGACAATTACAAACAGG AATC GAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCTGAATCAGGA TATT CTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAACCATGCATCAT CAGG AGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCAGTTTAGTCT GACC ATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAACAACTCTGGC GCAT CGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTATCGCGAGCCC ATTT ATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGGAGCAAGACGTTTC CCGT TGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAGTTTTATTGTT CATG ATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACAACGTGGCTTT GTTG AATAAATCGAACTTTTGCTGAGTTGAAGGATCAGAGCCTACGTTCCGAATACGGTCAAAA AAAA GGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAATTCTTTTAGGAAGCGT GTAT CGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGTTTGTGATACGCTCGA TACC CATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATTTGATTCAAGTACGTT CGGG TCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTACAGAACGGACATCCT TTAC CGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAGCAAACGGGAAGTAAG ACGG ACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAAGAGCAGCAATACCTG CTTC AAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACCTGATGGAAGAAACAG TGTG CGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGATGATGCGGATAGGAG GCTG TGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACGCAATACTACGTCCGG GTGA GCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCTTCGGCAAAGTTCAGT GCCG AGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGCTGAATCCCAGACGGG CAAA GATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGTACCGAGTTCTACAGG ATAA GCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTTTCAAACATTTCTTTC AGCG CGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCATGCCGACTTCTTTTT TCTG TTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGCTCCCTTCTTACTTAG GTAT TTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAGGCTTCCACCTCTTTC AGAA GTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCCGTTAAACAAAATTAT TTGT AGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACATCCGGTGACAGCTCAG GCTA CTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAGTTCAAGTGAAACTTT AAAT TTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAGCCCAATTGTAAAACG AAAG GCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTACAGTCGCTCGGCGATCGAAGGCTT CGGA AAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAATTCTTTTAG GAAG CGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGTTTGTGATA CGCT CGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATTTGATTCAA GTAC GTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTACAGAACGG ACAT CCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAGCAAACGGG AAGT AAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAAGAGCAGCA ATAC CTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACCTGATGGAA GAAA CAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGATGATGCGG ATAG GAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACGCAATACTA CGTC CGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCTTCGGCAAA GTTC AGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGCTGAATCCC AGAC GGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGTACCGAGTT CTAC AGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTTTCAAACAT TTCT TTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCATGCCGACT TCTT TTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGCTCCCTTCT TACT TAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAGGCTTCCAC CTCT TTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCCGTTAAACA AAAT TATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACATCCGGTGAC AGCT CAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAGTTCAAGTG AAAC TTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAGCCCAATTG TAAA ACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTAGGATCAGCTGTACGTAC TCGC AGTTCAACCTGTTGATAGTACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGT TTAA CGTACTAAGCTCTCATGTTTAACGAACTAAACCCTCATGGCTAACGTACTAAGCTCTCAT GGCT AACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTGAACAATAAAATTAAT ATAA ATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAAGAATATATAA GGCT TTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACAAGCCAGGGATGTAACGCACTGAGA AGCC CTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGGAACACTTAACGGCTGACATGGGGC GGCC GCGTAG [00248] SEQ ID NO: 92 (Plasmid encoding oxalate degradation pathway for genomic integration into Bacteroides vulgatus genome):

GGAGAGCTGTATGTGGGGTGGAAGAAGCTATCGTAAAAATGCTGGAGCAGCTTGATC CTCATTC TACCTATTCTGATCCGGAGGAAGTGAAGAGAATGAACGAGCCGTTGCAGGGAAACTTCGA AGGT ATCGGTATACAGTTTAATATGGCGGAGGACACTTTGCTGGTGATACAGCCTGTATCGGGC GGAC CGTCCGAAAAAGTCGGTATTCTGGCCGGTGATCGTATCGTCATGGTGGAAGATACGCTGA TAGC CGGTGTAAAGATGAGTACCGAGGATATTATGCGTCGCCTCCGTGGTCCTAAAGATTCAAA AGTG AATCTGAAAATACTTCGCCGAGGGGTGAAGGAACTGCTCCCCTTTACGGTGAAAAGGGAT AAAA TACCTGTTTACAGCTTGGATGCTTCCTATATGATTAAAGATAAGATCGGTTATATTCGTA TCAA CCGTTTTGCCGCCACTACCCATGAGGAGTTCAAGAAAGCGCTGACCGGGTTGCAGAAGAA AGGA ATGAAAGACTTGATTCTTGATTTGCAGGGCAATGGCGGGGGGTATTTGAATGCTGCTATC GATA TTGCCAATGAATTTTTGGGTAAAAAGGAACTGATTGTCTATACGGAGGGCCGTCGTAATC CTCG TAGCGAGTTTTTTGCCAAAGGTACGGGCGAGTTTCAGAACGGTCGTCTGATGGTATTGGT TGAT GAATTTTCGGCTTCTGCCAGTGAGATTGTGACCGGAGCTGTTCAGGATTGGGACAGAGGC GTTG TGGTAGGCCGTCGCAGTTTTGGTAAAGGCTTGGTGCAGCGTCCCATTGATTTGCCGGACG GTTC GATGATCCGTCTGACGGTGGCCCGCTATTATACGCCTGCCGGACGTTGTATCCAGAAACC TTAC GAGAGCATTGAAAAGTATAATGAAGACCTGATAGACCGTTATAATAAAGGAGAAATGATG AGTG AAGACAGCATCCACTTTCCGGATTCACTGAAGTTCAAGACTCATAGGTTGGCCCGTACGG TATA TGGTGGCGGAGGGATCATGCCCGATTATTTTGTGCCGATTGATACGACTCTCTATACTAA ATAC GTAAAGAATGGCTGGGCAAATACAAGACTTTCAATGAGTTCTACAAACGTTTTGAAGTGA CTCC GGATATGTTGACACAACTGGTTGCTACCGGCAAGGAGATGGGAGTGGAATATAATGAAGA AGAG TATCAAAAGGCCCTGCCTCTGCTGAGGTTGCAGATGAAAGCATTGATAGCCCGTGATTTA TGGG ATATGAATGAATATTATCACGTCATTAATGACGCGAATGAAAGTATCAGGAAAGCGCTGG AACT GTTGGAGCAACCGGACTTTGAGGGGCTGCTGTTGAAAAAGCGATAGTCAAGACTTTATAT TAAC TGCAGGGGCGCATAGTTGCACTCCTGCAGTTGTCTGAAAAACTTGTAGGATAAAACGAAA GGCT CAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGC AATG GTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTT GCAG TGTCGAAAGAAACAAAGTAGCCTGGCATCATCTACCTTCATTATTAAACAAACCAAATTA ATAT CATAAAAAAATAAAAAAATGACTACCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGA AGTA CGGAATTGATACTGTCTTCGGCATAGTAGGTATTCCGATCGTGCAGTTGGCCGACACTAT GGTC GCGAATGGAATTAAGTTTATACCGTGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGC GCCT ACGGCTACATCTCGGACAAACCTGGTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTC ATGC CTTAGCGGGGATCTATAATAGTATGTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATC CAGC AGCCAGTCAGACATCCACAAGGGAGGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGT CCGT TCCTAAAATTCACTGGTAAACTGACGCCGGATAACATCGATATGATAACCCAAAAAGCAC TCAA CTATTGCATTCAGGGAACCGCCGGAGTGAGCTATATCGATGTCCCCGCTGACTTCATCGA ATAC GAGAAGCCGCTTGAGGGCAATGATAGAACTGGTAACGAGCTGCCAATGATCCTGACGCCC AATA TCTGCGGTCCAGACCCCAGTAAAATTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGA ACAA GAACATATTAATAGTGATAGGTAAAGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTT GGTT AACACCTTTAACTTGCCGTTCCTTCCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGC AGCC CTTTAAATGTGAGCAGCGCCCGGAGCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTAT TGGG AGCTCGCCTGAATTGGATCCTTCACTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTAT TTTT ATACAATTTGACAGTAACCCGGAAACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGAT TTAA GTATCTGGGGGGACATCGGACTATCGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGG ACAG TTGTTGGAAATACTCGGGAGTCAAACAGGAGATCAGGGAAAAGATACAGTTAAACCAGAC CAGA TTGCTCCGTAAGGAAAAAACGCGTGGAGCTCAGCTTAACTATAATCAAGTGTACGGCACC CTTC GTCCGTTAATTGACGACTATCGCACGATCTTGGTCACAGAAGGTGCCAACACAATGGACA TCGC TAGAATAAGTTTTCCGACTGATGCACCTCGCAGAAGACTTGATGCTGGTACAAATGCTAC AATG GGTATAGGTTTAGGTTACGCATTAGCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTT TTAA TCCAAGGCGACAGTGCCTTCGGTTTTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCC AATT AGCCCTTGTGATTGTCGTAATGAATAACTCTGGGATATATCACGGTGAGAAAGACATCGA AGGA GATCTGCCCCCGACCGCTTTGTCAAAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTA GGAG CTAACGACTTCTTCGTCAATACCATCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTC AATT GAGCAGAACCAAGCGCGAAACCTCCGTCATTAATGTCATAATCGAACCGGGAGAGCAGAA ACAG ATCGCGTTCGCATGGCAAAACAAGCCTAGACTGTAAGGTTCCTAACCTGCCTGGCATCTT AATC AATTTTAAACTCACCAAATCAAAATATGAAAAAAAAAAATAATAAAATGTCAACTCCACT TCAA GGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGGCCCATCTTGTACTCAAATGCTG GCCT GGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGCGTTGGTGACGTAACGCGTCACC AGCT GCGAGATATTCCTGATATCGATGCGCTTTACTTCACCATGCTTAACAGTAACAAACGTTC TATT GAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAATGGAAAAGCTGATCCGCGAAGCT GATA TCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCACATGGGCTTCACCTGGGAGCATA TTCA AGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAGGGTTTGATGAGTGTTCGCCTTA TGTG AATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGGTGGCGCGGCATCCACTACGGGT TTTT GGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGTGACAGCAACACCGGAATGCATT TGCT GATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAACGGGGCGTGGGCAACGAGTCAC CATG TCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAAATTACGTGACCAGCAGCGTCTA GATA AATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAATGGTACATTTGGTGATGCAGTTC CCCG CGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGATCCTGAAATGTAAAGGCTGGGA AACC GATCCTAACGCCTATATTTATTTCACTATTCAGGAGCAAAACTGGGAAAACACCTGTAAA GCCA TCGGCAAACCAGAATGGATTACCGATCCGGCATACAGTACAGCCCATGCACGACAGCCAC ATAT TTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCACTATTGATAAACATGAAGCGGT GGCC TATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTTAAGTATGAAAGAAATTTCACTT GATC CCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAACAACCGTTGCGTGGAAAATATC TGAC CGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGGATATTAAAGCTGCGCCGCTATT AGGT GAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAGCGACGATGAAATTGCTGCAATG AAGC AAAACCACGCCATCTGAGGTTCCTAAACGACCTGGCATCATCTACCTTTATTAATCAACA ATCC AAATTATTAATAAAAAAAATTTAAAAAATGACAAATAATGAAAGCAAAGGGCCGTTTGAA GGCT TATTAGTTATCGATATGACACATGTCCTTAATGGACCTTTCGGAACTCAACTTCTTTGTA ATAT GGGCGCAAGGGTAATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACCCGCACATTTGG TCCC TATGTGGATGGACAGTCACTCTATTACAGTTTTATTAATCATGGCAAAGAGAGTGTGGTT CTTG ATTTAAAGAATGATCACGATAAAAGTATATTTATAAATATGCTCAAACAAGCTGATGTAT TAGC TGAGAATTTTCGCCCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAAACGCTTCAAGA AATC AACCCGCGCCTCATATATGCTTCATCGTCAGGTTTCGGACATACCGGTCCGCTAAAAGAT GCTC CTGCCTACGATACCATCATTCAGGCAATGAGCGGGATAATGATGGAAACAGGATATCCTG ATGC TCCGCCAGTGCGCGTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTCTATTTATTCAG CGGA ATAGTGAGTGCACTTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATGTCGATATAGCG ATGT TTGATGCCACGCTGAGTTTTCTGGAGCATGGTCTGATGGCATATATCGCAACTGGGAAGT CACC ACAACGTCTGGGAAATCGCCATCCCTACATGGCACCTTTTGATGTTTTCAATACTCAGGA TAAG CCGATTACGATTTGTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCCAGGCACTGGAG CTTA CGGAACTGGTTAATGATCCCCGATTTAGCAGCAATATTTTACGCGTACAAAACCAGGCTA TTCT TAAACAATATATTGAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGGTTAGCCAGAAT ACAT GAAGTTGGTGTACCCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTAAATTGCCACAA ACTC AGGCGAGAAATATGTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAATCCGATAAAAA TCAG CGGCTGCGCGGACCCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAGCATGGGGAACA AATT CGCCAGGAGTTCTCATCATAAGGTTCCTAAGGGTCCTGGCATCACCTAAAAATTATAAAT AAAT TAATAAACCTTTTAACATAAAAATTAATAAAATGAATAATCCACAAACAGGACAATCAAC AGGC CTCTTGGGCAATCGTTGGTTCTACTTGGTATTAGCAGTTTTGCTGATGTGTATGATCTCG GGTG TCCAATATTCCTGGACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTTCTTTGG CTGC GGTTCAGACGGCTTTCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGGTGGTGG TTAC TTCGTTGATAAATTCGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTTCTCGCT GGCT GGACCTTCATGGGTATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTCTGGCCG GTGC AGGTGTTGGTATCGTTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCCGGACAA ACGC GGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTCCTGCCA CTGA TCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTTTGATCA TGGG TATCCTGATTATCCTGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGCCAAAAA ACAA ATCGTTGTTACCGACAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAATTCTGG GTTC TGTGGACCGCATTCTTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACAGCGTCC CTTA CGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCAGAACCT GTTC AATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTACAAAACC ATGT CCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTGCCTTGG GCGA TGTAGCCTTTATCGCCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTACGCTCT GTTC CCATCGACCAACAGCGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGTTTCTTC TGGG CTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAACCAACT TCGG ATGGAATACCGCTTTCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCTGGCTAC CTTC GTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAAGAAAAA GCTG TACATTAAGGTTCCTAATTCCCCTGGCATCCCCAAAAAATTAATTCATTTTCTCTTTTCA ACAA TTTAAAAAAAATTAAAAAATGAGTAACGACGACAATGTAGAGTTGACTGATGGCTTTCAT GTTT TGATCGATGCCCTGAAAATGAATGACATCGATACCATGTATGGTGTTGTCGGCATTCCTA TCAC GAACCTGGCTCGTATGTGGCAAGATGACGGTCAGCGTTTTTACAGCTTCCGTCACGAACA ACAC GCAGGTTATGCAGCTTCTATCGCCGGTTACATCGAAGGAAAACCTGGCGTTTGCTTGACC GTTT CCGCCCCTGGCTTCCTGAACGGCGTGACTTCCCTGGCTCATGCAACCACCAACTGCTTCC CAAT GATCCTGTTGAGCGGTTCCAGTGAACGTGAAATCGTCGATTTGCAACAGGGCGATTACGA AGAA ATGGATCAGATGAATGTTGCACGTCCACACTGCAAAGCTTCTTTCCGTATCAACAGCATC AAAG ACATTCCAATCGGTATCGCTCGTGCAGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTG TTTA CGTTGACTTGCCAGCAAAACTGTTCGGTCAGACCATTTCTGTAGAAGAAGCTAACAAACT GCTC TTCAAACCAATCGATCCAGCTCCGGCACAGATTCCTGCTGAAGATGCTATCGCTCGCGCT GCTG ACCTGATCAAGAACGCCAAACGTCCAGTTATCATGCTGGGTAAAGGCGCTGCATACGCAC AATG CGACGACGAAATCCGCGCACTGGTTGAAGAAACCGGCATCCCATTCCTGCCAATGGGTAT GGCT AAAGGCCTGCTGCCTGACAACCATCCACAATCCGCTGCTGCAACCCGTGCTTTCGCACTG GCAC AGTGTGACGTTTGCGTACTGATCGGCGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAG GCAA AACCTGGGGCGACGAACTGAAGAAATACGTTCAGATCGACATCCAGGCTAACGAAATGGA CAGC AACCAGCCTATCGCTGCACCAGTTGTTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGC AAAG CACTGAAAGGCGCTCCAAAAGCTGACGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTG ACGG CAACAAAGCCAAACTGGCTGGCAAGATGACTGCCGAAACCCCATCCGGAATGATGAACTA CTCC AATTCCCTGGGCGTTGTTCGTGACTTCATGCTGGCAAATCCGGATATTTCCCTGGTTAAC GAAG GCGCTAATGCACTCGACAACACTCGTATGATTGTTGACATGCTGAAACCACGCAAACGTC TTGA CTCCGGTACCTGGGGTGTTATGGGTATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGT TACC GGCAAACCGGTTATCGCTGTTGAAGGCGATAGCGCATTCGGTTTCTCCGGTATGGAACTG GAAA CCATCTGCCGTTACAACCTGCCAGTTACCGTTATCATCATGAACAATGGTGGTATCTATA AAGG TAACGAAGCAGATCCACAACCAGGCGTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTA CGAC ATGATGATGGAAGCATTTGGCGGTAAAGGTTATGTTGCCAATACTCCAGCAGAACTGAAA GCTG CTCTGGAAGAAGCTGTTGCTTCCGGCAAACCATGCCTGATCAACGCGATGATCGATCCAG ACGC TGGTGTCGAATCTGGCCGTATCAAGAGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAATA AGGT TCCTAAAATGCCTGGCATCTAAACTAAAATACAATAACCAAAAATCATCTATGCGTAAAA AAAA TTATAAAATGGATAGCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCC CGAT CGCCGAGCTCTCTCCGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTA ATCG AACGCGCCGCTTCACGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTC TCAC CTTCCCTAACACCGTCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCAC GGCG GCGCCGTTGAACGCAGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGAT TCAA AGCTATTGTTAACCTCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGA AAAT CTCTCACGTCACCGCTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGA TTCA GATTCCGTCGTTGACTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTC CTCC ACACTTCTGGCACTACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTT CATC CGTCAAGAACATTAAAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCT CCCT CTGTTCCATGTTCATGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCT GTAA CTCTTCCAGCTGCTGGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATA ACGC TACATGGTATACTGCTGTGCCGACCATTCATCAGATCATATTGGACCGCCACGCGAGCCA CCCT GAAACGGAATATCCTAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTG ATAT TGTCCAGGCTTGAGGAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGG CAAC ACATTTGATGAGCTCAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGG GAAA CCGGTAGGTCAAGAAATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAAC AAAG GAGAGGTTTGTATAAGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCA ACAA GGCAGGTTTCGAGTTTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGATACCGATGG GTAT TTGCATCTGGTGGGTCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCA ATTG AAGTGGATGCAGTACTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTC CTGA TGAGAAATATGGGGAAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAAC CGAA GAGGACATTAAAGCGTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTG TTCA TCACTGATAACCTCCCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAAC ATTT CCTTGAGAAGCCCTGAGGTTCCTAAAAACCCTGGCATCTTTTCCATAACAAAAATTAAAC CTCC TCCATATGAAAAATAAAAATTATAAAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCA ACGA TACTTTTAGCGTATCCGATAATGTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGAC CTAC AGGGATCTATCCCACATGGTGGGTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCA TTGT ACGGAGCTGTTTTCAGACAAGATACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTA TCGT CGCTTTCCTCGGTGCTACTATGGACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAA GGAA AAGGAGTTCAATTTTTATTTGAATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGT ACCA CAAAGTTACAGAGTTCTGAAATTCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAG AGCT GGCCTTCGATGCGACCAGGTTTAGGGTAGAGTATGATATATACTCTCCAGAGGACAACTA CAAA AGGGTTATTTACCGGTCTTTGAACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTC CCTG GGTTTGCCCGTTCCAGTGACGTTGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTC CAAA AACGGTGCCTTTGTTACATTTGAACATTGTGAGAAGCACGTTGAACATTGCTAACACTTA CAAG CTAACGCCCTTGGACAGATCTTATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATT GGTG TTTTACTTTCCACTTTTAGAACTCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAA AGTT ATTCTGGGACCAATTTGTTAAGTACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAG CATG ATTATGCTGAACATGCCCAAACCAAACCCTTTCCCACACATTAGATTCATCAGATCGTGT TCTT CTGCTTTGGCTCCAGCAACGTTCCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGG AGGC CTATGCGATGACCGAAGCATCACATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAG AAAG CCTGGTACTGTGGGCCAGCCACAAGGAGTCACCGTCGTCATTCTAGATGACAATGACAAT GTCT TGCCCCCGGGCAAAGTCGGCGAAGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATG CTAA TAATCCAAAAGCTAACAAGGAGAACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGA CCAA GGTTATTTCGACCCTGAGGGGTTTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAAC AGGG GTGGTGAAAAGATTTCACCCATTGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCG ATGA AGCCGTTGCATTTGGTGTTCCCGACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGT TTTG AAGAAGGGAGAAAAAATGACCTACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCC TCTT TCAAAATTCCAACCAAGGTGTACTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAA TCCA GAGAAGAGTTATCGCAGAAACTTTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGG TTCC TAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTCTGTTGTGTCTTCTT TTAG GTGTGGAATAATTTTCCAACCATCACTTTATCTGTCTCCCGAACAGCACCTTATTCAGCC ATCG GTTCACATACACGTTCACGAAAGCACATCCTACTCCGATAGCGGCTCCTGCCACTACATC ACTG GGATAGTGCACCCCTTGGTTCATCCGGGCAAACCCTACTCCGCAAGCCCATACGGCTGAA GGGG CGATAACATACCACTTAGGATAAGTGATGGAGAGTGAGGTGGCTAAAGAAAAAGCTGCCG CAGT GTGTCCTGAAGGGAATGACGGACTATCGGCATCCGGTGCTCCGTATGCATGAATCTTATC CGGA TACTTTACAAAAGGCCGGTCACGACCTATTATATGTTTGGCGGCGTATGTAATCCCCACT GCTT CAATCACACTGGTTCCTATGTAAATGGCATCTTTCAGCATCGGCTGGTCTTTCTTTATCA ATGC ATAGAGTCCCATGGCTGTAGGTATTCCTACGGGTAGAATCACTCCGCTAGCGGACAATCC GCGG CTCAGTCCGTGTACATCCCATCGGTTGATGGTTTTCAACGTGTTGATGTCTATATTCTGT GCGC TGAGGCTGAATGTAAAACAGGCTGTCAGTATAAGAAAAATAATCCTTTGGCGTTTCATTT AGTT TGGCATTTGTTCAGTGCAAAGATAGGAAAATAATGTAATTCGCATTTACCCTTCCCCGAA TTAA AGAATAATTTCCATAATTCCTTGTATTATCGCTAGAATTCCTTTACTTTTGCATCGTGAA TACA CAGCTTTTAACAGAATTTTTAGTTCTAACAATTAAATAATTTAAATTCAATCATTTATGT GGTT AAGTAATTCATCTATTGGAAGGAAAGTGGTGATGAGTGTCACAGGTATCGCCCTTGTCCT GTTT CTGACGTTTCACATGGCGATGAACCTTGTTGCGCTCTTCTCGGAAGATGCTTACAACATG ATTT GTGAATTCTTGGGAGCTAACTGGTACGCGTTGGTTGCAACTGCCGGGCTGGCTGCTCTGT TTGT AATTCACATCATCTACGCTTTCTGGTTGACCATGCAGAACCGTGCAGCTCGCGGTAGCGA ACGT TATGCAGTGAACGTTAAACCTAAAACTGTGGAATGGGCATCTCAGAACATGCTTGTCCTG GGTA TTGTCGTTATTGCCGGATTGGCTCTTCATTTTGCCAATTTCTGGTACAAAATGCAGTTTG CCGA AATTATCGGTGTTCATGATTTGGGCGCATTCGGTCCTACAGACGGTGCCGCTTACATTCG TGAA ACATTCGGATGCCCTGTATTTACAGTGCTTTACCTCATTTGGTTAGCAGCTTTGTGGTTC CACC TGACTCACGGATTCTGGAGTGCTTTGCAGACTTTGGGCTGGAGCAATAAAATCTGGTTCG AGCG TTGGAAGACTATTGGTAACATCTACTCTACTTTGGTAGTTCTTGGTTTTGCAGCAGTAGT CGTT ATCTACTTCGCTATGACTGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGT TTCA TCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCA GGAT TCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGG GTGG GCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACG AACC CTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATA ATGA CCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCGGGGATTGGTGAACAAA AAGG TGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGATATTGAGGTATCATTTT ATCG TAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAAATTTTAGCATTTTGTA AAAA AGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTTGCATCCCGAAGAGTTT CTCT TAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTTTATGTCGTAAAGAGGG GCTT TGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTAGTTGAAACACATAGAA AGTT GCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTACGTTCTTTTCTCAAAA AACA TAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAATGAACAAAGTAAATAT AAAA GATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAATAATGAATTGCATAAGT TTAG ATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCATTTTACTGCTGGATTGG TAAA GAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTATGTGAGGTAACTCGTAA TAAG CTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACTGAAATTTACATTTCCT AGCC ACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGCACAAATATAATTCGAA AAAT TGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAATATGGTTTTGCTAAAAT GTTA TTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGTAGATATTTCTATATTA GCAA AAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGCACATTAATTGTATTAA AAAG AAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAACTTTTGTAATGAAATG GGTT AACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAAAGCTTTAAAACATGCG AGAA TATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTATTTAATAGTTATAAAA TATT TAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTACGCGGGTACCGACACCG CGGT GGAGGGGAATTGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCATC AAAT GAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTTCT GTAA TGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTGC GATT CCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATCA AGTG AGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCTT TCCA GACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAACC GTTA TTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGACAATTA CAAA CAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCTG AATC AGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAACCA TGCA TCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCAG TTTA GTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAACA ACTC TGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTATC GCGA GCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGGAGCAA GACG TTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAGTT TTAT TGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACAAC GTGG CTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGAGCCTACGTTCCGAATAC GGTC AAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAATTCTTTTA GGAA GCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGTTTGTGAT ACGC TCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATTTGATTCA AGTA CGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTACAGAACG GACA TCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAGCAAACGG GAAG TAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAAGAGCAGC AATA CCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACCTGATGGA AGAA ACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGATGATGCG GATA GGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACGCAATACT ACGT CCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCTTCGGCAA AGTT CAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGCTGAATCC CAGA CGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGTACCGAGT TCTA CAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTTTCAAACA TTTC TTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCATGCCGAC TTCT TTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGCTCCCTTC TTAC TTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAGGCTTCCA CCTC TTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCCGTTAAAC AAAA TTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACATCCGGTGA CAGC TCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAGTTCAAGT GAAA CTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAGCCCAATT GTAA AACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTACAGTCGCTCGGCGATC GAAG GCTTCGGAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAAT TCTT TTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGT TTGT GATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATT TGAT TCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTA CAGA ACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAG CAAA CGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAA GAGC AGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACC TGAT GGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGA TGAT GCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACG CAAT ACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCT TCGG CAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGC TGAA TCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGT ACCG AGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTT TCAA ACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCA TGCC GACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGC TCCC TTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAG GCTT CCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCC GTTA AACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACAT CCGG TGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAG TTCA AGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAG CCCA ATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTAGGATCAGCT GTAC GTACTCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCATGTTTCACGTACTAAGC TCTC ATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTCATGGCTAACGTACTAA GCTC TCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTGAACAATA AAAT TAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAAGA ATAT ATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACAAGCCAGGGATGTAACG CACT GAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGGAACACTTAACGGCTGA CATG GGGCGGCCGCGTAG

[00249] SEQ ID NO: 93 (Plasmid encoding oxalate degradation pathway for genomic integration into Bacteroides vulgatus genome):

GGAGAGCTGTATGTGGGGTGGAAGAAGCTATCGTAAAAATGCTGGAGCAGCTTGATC CTCATTC TACCTATTCTGATCCGGAGGAAGTGAAGAGAATGAACGAGCCGTTGCAGGGAAACTTCGA AGGT ATCGGTATACAGTTTAATATGGCGGAGGACACTTTGCTGGTGATACAGCCTGTATCGGGC GGAC CGTCCGAAAAAGTCGGTATTCTGGCCGGTGATCGTATCGTCATGGTGGAAGATACGCTGA TAGC CGGTGTAAAGATGAGTACCGAGGATATTATGCGTCGCCTCCGTGGTCCTAAAGATTCAAA AGTG AATCTGAAAATACTTCGCCGAGGGGTGAAGGAACTGCTCCCCTTTACGGTGAAAAGGGAT AAAA TACCTGTTTACAGCTTGGATGCTTCCTATATGATTAAAGATAAGATCGGTTATATTCGTA TCAA CCGTTTTGCCGCCACTACCCATGAGGAGTTCAAGAAAGCGCTGACCGGGTTGCAGAAGAA AGGA ATGAAAGACTTGATTCTTGATTTGCAGGGCAATGGCGGGGGGTATTTGAATGCTGCTATC GATA TTGCCAATGAATTTTTGGGTAAAAAGGAACTGATTGTCTATACGGAGGGCCGTCGTAATC CTCG TAGCGAGTTTTTTGCCAAAGGTACGGGCGAGTTTCAGAACGGTCGTCTGATGGTATTGGT TGAT GAATTTTCGGCTTCTGCCAGTGAGATTGTGACCGGAGCTGTTCAGGATTGGGACAGAGGC GTTG TGGTAGGCCGTCGCAGTTTTGGTAAAGGCTTGGTGCAGCGTCCCATTGATTTGCCGGACG GTTC GATGATCCGTCTGACGGTGGCCCGCTATTATACGCCTGCCGGACGTTGTATCCAGAAACC TTAC GAGAGCATTGAAAAGTATAATGAAGACCTGATAGACCGTTATAATAAAGGAGAAATGATG AGTG AAGACAGCATCCACTTTCCGGATTCACTGAAGTTCAAGACTCATAGGTTGGCCCGTACGG TATA TGGTGGCGGAGGGATCATGCCCGATTATTTTGTGCCGATTGATACGACTCTCTATACTAA ATAC CATCGTCAGTTGCGTGATAAAGGAGCATTGATGAAAGCTCATTTCCATTTTATTGATGCC CATC GTAAAGAATGGCTGGGCAAATACAAGACTTTCAATGAGTTCTACAAACGTTTTGAAGTGA CTCC GGATATGTTGACACAACTGGTTGCTACCGGCAAGGAGATGGGAGTGGAATATAATGAAGA AGAG TATCAAAAGGCCCTGCCTCTGCTGAGGTTGCAGATGAAAGCATTGATAGCCCGTGATTTA TGGG ATATGAATGAATATTATCACGTCATTAATGACGCGAATGAAAGTATCAGGAAAGCGCTGG AACT GTTGGAGCAACCGGACTTTGAGGGGCTGCTGTTGAAAAAGCGATAGTCAAGACTTTATAT TAAC TGCAGGGGCGCATAGTTGCACTCCTGCAGTTGTCTGAAAAACTTGTAGGATAAAACGAAA GGCT CAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGC AATG GTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTT GCAG TGTCGAAAGAAACAAAGTAGCCTGGCATCACCTAAAAATTATAAATAAATTAATAAACTT TTAT TAAAAAAAAATTACAAAATGAATAATCCACAAACAGGACAATCAACAGGCCTCTTGGGCA ATCG ACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACG GCTT TCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATA AATT CGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCAT GGGT ATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGT ATCG TTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTT CCGG TTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGT TCTG AAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTTTGATCATGGGTATCCTGATT ATCC TGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTA CCGA CAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAATTCTGGGTTCTGTGGACCGC ATTC TTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGC CTCG GTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTT GCCG TCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTT CGGT ATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTT ATCG CCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCA ACAG CGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGC AACT GCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAACCAACTTCGGATGGAATACC GCTT TCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAA GAAT GGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAAGAAAAAGCTGTACATTAAGG TTCC TAACCTGCCTGGCATCTTAATCAATTTTAAACTCACCAAATCAAAATATGAAAAAAAAAA ATAA TAAAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGG CCCA TCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGC GTTG GTGACGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTTTACTTCACCA TGCT TAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAAT GGAA AAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCAC ATGG GCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAG GGTT TGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGG TGGC GCGGCATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGT GACA GCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAA CGGG GCGTGGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAA ATTA CGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAAT GGTA CATTTGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGA TCCT GAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTATTCAGGAGCA AAAC TGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCCGGCATACAGT ACAG CCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCA CTAT TGATAAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTT AAGT ATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAA CAAC CGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGG ATAT TAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAG CGAC GATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTAAACGACCTGGCAT CAAC TACCTTTATTATTCAACAAACCAATTTAACATATTAAAAAAATAAAAAAATGACTACCAC AGCA ACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCGGCATAGTA GGTA TTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTATACCGTGTC GCAA TGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAACCTGGTGT CCTG TTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATAGTATGTCG AACC GCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAAGGGAGGTT TCCA GGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAACTGACGCC GGAT AACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCGCCGGAGTG AGCT ATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAATGATAGAA CTGG TAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGTAAAATTAA GAAG GTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAGGTAAAGGA GCAG TGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTTCCTTCCGA CTCC CATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCCCGGAGCCA GGCT CTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCCTTCACTTC GGAA CGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCCGGAAACGC TCGG AGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGACTATCGGT TACT GCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAGTCAAACAG GAGA TCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAACGCGTGGAG CTCA GCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTATCGCACGAT CTTG GTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTGATGCACCT CGCA GAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGCATTAGCGT GTAA AGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTCGGTTTTAG CGCT ATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAATGAATAAC TCTG GGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTTGTCAAAAA ATTG TAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAATACCATCTC AGAG TTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAACCTCCGTC ATTA ATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAACAAGCCTA GACT GTAAGGTTCCTAAGGGTCCTGGCATCAACTACCTAAATTACTTATCAAACCACTTAGTAG TAAA AAAAATATAACAAAATGACAAATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTA TCGA TATGACACATGTCCTTAATGGACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAG GGTA ATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACCCGCACATTTGGTCCCTATGTGGAT GGAC AGTCACTCTATTACAGTTTTATTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGA ATGA TCACGATAAAAGTATATTTATAAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTT TCGC CCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGC CTCA TATATGCTTCATCGTCAGGTTTCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACG ATAC CATCATTCAGGCAATGAGCGGGATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGT GCGC GTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGT GCAC TTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCA CGCT GAGTTTTCTGGAGCATGGTCTGATGGCATATATCGCAACTGGGAAGTCACCACAACGTCT GGGA AATCGCCATCCCTACATGGCACCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACG ATTT GTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGG TTAA TGATCCCCGATTTAGCAGCAATATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATA TATT GAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGT GTAC CCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAA ATAT GTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGC GGAC CCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAG TTCT CATCATAAGGTTCCTAATTCCCCTGGCATCTTTTCCATAACAAAAATTAAACCTCCTCCA TATG AAAAATAAAAATTATAAAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCAACGATACT TTTA GCGTATCCGATAATGTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGACCTACAGGG ATCT ATCCCACATGGTGGGTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCATTGTACGG AGCT GTTTTCAGACAAGATACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTATCGTCGCT TTCC TCGGTGCTACTATGGACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGG AGTT CAATTTTTATTTGAATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAA GTTA CAGAGTTCTGAAATTCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCC TTCG ATGCGACCAGGTTTAGGGTAGAGTATGATATATACTCTCCAGAGGACAACTACAAAAGGG TTAT TTACCGGTCTTTGAACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTCCCTGGGTT TGCC CGTTCCAGTGACGTTGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTCCAAAAACG GTGC CTTTGTTACATTTGAACATTGTGAGAAGCACGTTGAACATTGCTAACACTTACAAGCTAA CGCC CTTGGACAGATCTTATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTT ACTT TCCACTTTTAGAACTCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAAAGTTATTC TGGG ACCAATTTGTTAAGTACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAGCATGATTA TGCT GAACATGCCCAAACCAAACCCTTTCCCACACATTAGATTCATCAGATCGTGTTCTTCTGC TTTG GCTCCAGCAACGTTCCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGGAGGCCTAT GCGA TGACCGAAGCATCACATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTG GTAC TGTGGGCCAGCCACAAGGAGTCACCGTCGTCATTCTAGATGACAATGACAATGTCTTGCC CCCG GGCAAAGTCGGCGAAGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATGCTAATAAT CCAA AAGCTAACAAGGAGAACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGACCAAGGTT ATTT CGACCCTGAGGGGTTTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGG TGAA AAGATTTCACCCATTGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCGATGAAGCC GTTG CATTTGGTGTTCCCGACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGA AGGG AGAAAAAATGACCTACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAA AATT CCAACCAAGGTGTACTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAATCCAGAGA AGAG TTATCGCAGAAACTTTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGGTTCCTAAA ATGC CTGGCATCAACTACCTAAATTAATTATCACCCCAAATTAATAACATAAAAATATAATAAA ATGA GTAACGACGACAATGTAGAGTTGACTGATGGCTTTCATGTTTTGATCGATGCCCTGAAAA TGAA TGACATCGATACCATGTATGGTGTTGTCGGCATTCCTATCACGAACCTGGCTCGTATGTG GCAA GATGACGGTCAGCGTTTTTACAGCTTCCGTCACGAACAACACGCAGGTTATGCAGCTTCT ATCG CCGGTTACATCGAAGGAAAACCTGGCGTTTGCTTGACCGTTTCCGCCCCTGGCTTCCTGA ACGG CGTGACTTCCCTGGCTCATGCAACCACCAACTGCTTCCCAATGATCCTGTTGAGCGGTTC CAGT GAACGTGAAATCGTCGATTTGCAACAGGGCGATTACGAAGAAATGGATCAGATGAATGTT GCAC GTCCACACTGCAAAGCTTCTTTCCGTATCAACAGCATCAAAGACATTCCAATCGGTATCG CTCG TGCAGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTGTTTACGTTGACTTGCCAGCAAA ACTG TTCGGTCAGACCATTTCTGTAGAAGAAGCTAACAAACTGCTCTTCAAACCAATCGATCCA GCTC CGGCACAGATTCCTGCTGAAGATGCTATCGCTCGCGCTGCTGACCTGATCAAGAACGCCA AACG TCCAGTTATCATGCTGGGTAAAGGCGCTGCATACGCACAATGCGACGACGAAATCCGCGC ACTG GTTGAAGAAACCGGCATCCCATTCCTGCCAATGGGTATGGCTAAAGGCCTGCTGCCTGAC AACC ATCCACAATCCGCTGCTGCAACCCGTGCTTTCGCACTGGCACAGTGTGACGTTTGCGTAC TGAT CGGCGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAGGCAAAACCTGGGGCGACGAACT GAAG AAATACGTTCAGATCGACATCCAGGCTAACGAAATGGACAGCAACCAGCCTATCGCTGCA CCAG TTGTTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGCAAAGCACTGAAAGGCGCTCCAA AAGC TGACGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTGACGGCAACAAAGCCAAACTGGC TGGC AAGATGACTGCCGAAACCCCATCCGGAATGATGAACTACTCCAATTCCCTGGGCGTTGTT CGTG ACTTCATGCTGGCAAATCCGGATATTTCCCTGGTTAACGAAGGCGCTAATGCACTCGACA ACAC TCGTATGATTGTTGACATGCTGAAACCACGCAAACGTCTTGACTCCGGTACCTGGGGTGT TATG GGTATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGTTACCGGCAAACCGGTTATCGCT GTTG AAGGCGATAGCGCATTCGGTTTCTCCGGTATGGAACTGGAAACCATCTGCCGTTACAACC TGCC AGTTACCGTTATCATCATGAACAATGGTGGTATCTATAAAGGTAACGAAGCAGATCCACA ACCA GGCGTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTACGACATGATGATGGAAGCATTT GGCG GTAAAGGTTATGTTGCCAATACTCCAGCAGAACTGAAAGCTGCTCTGGAAGAAGCTGTTG CTTC CGGCAAACCATGCCTGATCAACGCGATGATCGATCCAGACGCTGGTGTCGAATCTGGCCG TATC AAGAGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAATAAGGTTCCTAAAAACCCTGGCAT CTAA ACTAAAATACAATAACCAAAAATCATTACAAATGAAAAAAAATAATAAAATGGATAGCGA TACT CTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCCCGATCGCCGAGCTCTCTCCGTT TCTG GAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTAATCGAACGCGCCGCTTCACGCC TTGT CTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTCTCACCTTCCCTAACACCGTCGA GTTT GTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCACGGCGGCGCCGTTGAACGCAGCG TACA CGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGATTCAAAGCTATTGTTAACCTCTA AAGA AGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGAAAATCTCTCACGTCACCGCTAC GCTG CTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGATTCAGATTCCGTCGTTGACTCA GCGA CGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTCCTCCACACTTCTGGCACTACGA GCCG TCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTTCATCCGTCAAGAACATTAAAGC TGTG TACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCTCCCTCTGTTCCATGTTCATGGA TTGT TAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCTGTAACTCTTCCAGCTGCTGGTA GATT CTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATAACGCTACATGGTATACTGCTGT GCCG ACCATTCATCAGATCATATTGGACCGCCACGCGAGCCACCCTGAAACGGAATATCCTAAA CTCC GGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTGATATTGTCCAGGCTTGAGGAAG CGTT TGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGGCAACACATTTGATGAGCTCAAA CCCC TTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGGGAAACCGGTAGGTCAAGAAATG GCGA TCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAACAAAGGAGAGGTTTGTATAAGAG GTCC AAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCAACAAGGCAGGTTTCGAGTTTGG GTGG TTCCACACTGGTGATATCGGTTACTTTGATACCGATGGGTATTTGCATCTGGTGGGTCGG ATCA AAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCAATTGAAGTGGATGCAGTACTCT TAAC GCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTCCTGATGAGAAATATGGGGAAGA GATT AACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAACCGAAGAGGACATTAAAGCGTTT TGTA AGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTGTTCATCACTGATAACCTCCCCA AAAC TGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAACATTTCCTTGAGAAGCCCTGAGG TTCC TAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTCTGTTGTGTCTTCTT TTAG GTGTGGAATAATTTTCCAACCATCACTTTATCTGTCTCCCGAACAGCACCTTATTCAGCC ATCG GTTCACATACACGTTCACGAAAGCACATCCTACTCCGATAGCGGCTCCTGCCACTACATC ACTG GGATAGTGCACCCCTTGGTTCATCCGGGCAAACCCTACTCCGCAAGCCCATACGGCTGAA GGGG CGATAACATACCACTTAGGATAAGTGATGGAGAGTGAGGTGGCTAAAGAAAAAGCTGCCG CAGT GTGTCCTGAAGGGAATGACGGACTATCGGCATCCGGTGCTCCGTATGCATGAATCTTATC CGGA TACTTTACAAAAGGCCGGTCACGACCTATTATATGTTTGGCGGCGTATGTAATCCCCACT GCTT CAATCACACTGGTTCCTATGTAAATGGCATCTTTCAGCATCGGCTGGTCTTTCTTTATCA ATGC ATAGAGTCCCATGGCTGTAGGTATTCCTACGGGTAGAATCACTCCGCTAGCGGACAATCC GCGG CTCAGTCCGTGTACATCCCATCGGTTGATGGTTTTCAACGTGTTGATGTCTATATTCTGT GCGC TGAGGCTGAATGTAAAACAGGCTGTCAGTATAAGAAAAATAATCCTTTGGCGTTTCATTT AGTT TGGCATTTGTTCAGTGCAAAGATAGGAAAATAATGTAATTCGCATTTACCCTTCCCCGAA TTAA AGAATAATTTCCATAATTCCTTGTATTATCGCTAGAATTCCTTTACTTTTGCATCGTGAA TACA CAGCTTTTAACAGAATTTTTAGTTCTAACAATTAAATAATTTAAATTCAATCATTTATGT GGTT AAGTAATTCATCTATTGGAAGGAAAGTGGTGATGAGTGTCACAGGTATCGCCCTTGTCCT GTTT CTGACGTTTCACATGGCGATGAACCTTGTTGCGCTCTTCTCGGAAGATGCTTACAACATG ATTT GTGAATTCTTGGGAGCTAACTGGTACGCGTTGGTTGCAACTGCCGGGCTGGCTGCTCTGT TTGT AATTCACATCATCTACGCTTTCTGGTTGACCATGCAGAACCGTGCAGCTCGCGGTAGCGA ACGT TATGCAGTGAACGTTAAACCTAAAACTGTGGAATGGGCATCTCAGAACATGCTTGTCCTG GGTA TTGTCGTTATTGCCGGATTGGCTCTTCATTTTGCCAATTTCTGGTACAAAATGCAGTTTG CCGA AATTATCGGTGTTCATGATTTGGGCGCATTCGGTCCTACAGACGGTGCCGCTTACATTCG TGAA ACATTCGGATGCCCTGTATTTACAGTGCTTTACCTCATTTGGTTAGCAGCTTTGTGGTTC CACC TGACTCACGGATTCTGGAGTGCTTTGCAGACTTTGGGCTGGAGCAATAAAATCTGGTTCG AGCG TTGGAAGACTATTGGTAACATCTACTCTACTTTGGTAGTTCTTGGTTTTGCAGCAGTAGT CGTT ATCTACTTCGCTATGACTGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGT TTCA TCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCA GGAT TCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGG GTGG GCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACG AACC CTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATA ATGA CCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCGGGGATTGGTGAACAAA AAGG TGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGATATTGAGGTATCATTTT ATCG TAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAAATTTTAGCATTTTGTA AAAA AGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTTGCATCCCGAAGAGTTT CTCT TAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTTTATGTCGTAAAGAGGG GCTT TGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTAGTTGAAACACATAGAA AGTT GCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTACGTTCTTTTCTCAAAA AACA TAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAATGAACAAAGTAAATAT AAAA GATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAATAATGAATTGCATAAGT TTAG ATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCATTTTACTGCTGGATTGG TAAA GAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTATGTGAGGTAACTCGTAA TAAG CTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACTGAAATTTACATTTCCT AGCC ACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGCACAAATATAATTCGAA AAAT TGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAATATGGTTTTGCTAAAAT GTTA TTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGTAGATATTTCTATATTA GCAA AAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGCACATTAATTGTATTAA AAAG AAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAACTTTTGTAATGAAATG GGTT AACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAAAGCTTTAAAACATGCG AGAA TATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTATTTAATAGTTATAAAA TATT TAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTACGCGGGTACCGACACCG CGGT GGAGGGGAATTGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCATC AAAT GAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTTCT GTAA TGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTGC GATT CCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATCA AGTG AGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCTT TCCA GACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAACC GTTA TTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGACAATTA CAAA CAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCTG AATC AGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAACCA TGCA TCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCAG TTTA GTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAACA ACTC TGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTATC GCGA GCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGGAGCAA GACG TTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAGTT TTAT TGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACAAC GTGG CTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGAGCCTACGTTCCGAATAC GGTC AAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAATTCTTTTA GGAA GCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGTTTGTGAT ACGC TCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATTTGATTCA AGTA CGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTACAGAACG GACA TCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAGCAAACGG GAAG TAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAAGAGCAGC AATA CCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACCTGATGGA AGAA ACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGATGATGCG GATA GGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACGCAATACT ACGT CCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCTTCGGCAA AGTT CAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGCTGAATCC CAGA CGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGTACCGAGT TCTA CAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTTTCAAACA TTTC TTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCATGCCGAC TTCT TTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGCTCCCTTC TTAC TTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAGGCTTCCA CCTC TTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCCGTTAAAC AAAA TTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACATCCGGTGA CAGC TCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAGTTCAAGT GAAA CTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAGCCCAATT GTAA AACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTACAGTCGCTCGGCGATC GAAG GCTTCGGAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAAT TCTT TTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGT TTGT GATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATT TGAT TCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTA CAGA ACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAG CAAA CGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAA GAGC AGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACC TGAT GGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGA TGAT GCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACG CAAT ACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCT TCGG CAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGC TGAA TCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGT ACCG AGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTT TCAA ACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCA TGCC GACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGC TCCC TTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAG GCTT CCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCC GTTA AACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACAT CCGG TGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAG TTCA AGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAG CCCA ATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTAGGATCAGCT GTAC GTACTCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCATGTTTCACGTACTAAGC TCTC ATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTCATGGCTAACGTACTAA GCTC TCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTGAACAATA AAAT TAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAAGA ATAT ATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACAAGCCAGGGATGTAACG CACT GAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGGAACACTTAACGGCTGA CATG GGGCGGCCGCGTAG [00250] SEQ ID NO: 94 (Ribosome binding site and At_AAE3 open reading frame):

GGAGAGCTGTATGTGGGGTGGAAGAAGCTATCGTAAAAATGCTGGAGCAGCTTGATC CTCATTC TACCTATTCTGATCCGGAGGAAGTGAAGAGAATGAACGAGCCGTTGCAGGGAAACTTCGA AGGT ATCGGTATACAGTTTAATATGGCGGAGGACACTTTGCTGGTGATACAGCCTGTATCGGGC GGAC CGTCCGAAAAAGTCGGTATTCTGGCCGGTGATCGTATCGTCATGGTGGAAGATACGCTGA TAGC CGGTGTAAAGATGAGTACCGAGGATATTATGCGTCGCCTCCGTGGTCCTAAAGATTCAAA AGTG AATCTGAAAATACTTCGCCGAGGGGTGAAGGAACTGCTCCCCTTTACGGTGAAAAGGGAT AAAA TACCTGTTTACAGCTTGGATGCTTCCTATATGATTAAAGATAAGATCGGTTATATTCGTA TCAA CCGTTTTGCCGCCACTACCCATGAGGAGTTCAAGAAAGCGCTGACCGGGTTGCAGAAGAA AGGA ATGAAAGACTTGATTCTTGATTTGCAGGGCAATGGCGGGGGGTATTTGAATGCTGCTATC GATA TTGCCAATGAATTTTTGGGTAAAAAGGAACTGATTGTCTATACGGAGGGCCGTCGTAATC CTCG TAGCGAGTTTTTTGCCAAAGGTACGGGCGAGTTTCAGAACGGTCGTCTGATGGTATTGGT TGAT GAATTTTCGGCTTCTGCCAGTGAGATTGTGACCGGAGCTGTTCAGGATTGGGACAGAGGC GTTG TGGTAGGCCGTCGCAGTTTTGGTAAAGGCTTGGTGCAGCGTCCCATTGATTTGCCGGACG GTTC GATGATCCGTCTGACGGTGGCCCGCTATTATACGCCTGCCGGACGTTGTATCCAGAAACC TTAC GAGAGCATTGAAAAGTATAATGAAGACCTGATAGACCGTTATAATAAAGGAGAAATGATG AGTG AAGACAGCATCCACTTTCCGGATTCACTGAAGTTCAAGACTCATAGGTTGGCCCGTACGG TATA TGGTGGCGGAGGGATCATGCCCGATTATTTTGTGCCGATTGATACGACTCTCTATACTAA ATAC CATCGTCAGTTGCGTGATAAAGGAGCATTGATGAAAGCTCATTTCCATTTTATTGATGCC CATC GTAAAGAATGGCTGGGCAAATACAAGACTTTCAATGAGTTCTACAAACGTTTTGAAGTGA CTCC GGATATGTTGACACAACTGGTTGCTACCGGCAAGGAGATGGGAGTGGAATATAATGAAGA AGAG TATCAAAAGGCCCTGCCTCTGCTGAGGTTGCAGATGAAAGCATTGATAGCCCGTGATTTA TGGG ATATGAATGAATATTATCACGTCATTAATGACGCGAATGAAAGTATCAGGAAAGCGCTGG AACT GTTGGAGCAACCGGACTTTGAGGGGCTGCTGTTGAAAAAGCGATAGTCAAGACTTTATAT TAAC TGCAGGGGCGCATAGTTGCACTCCTGCAGTTGTCTGAAAAACTTGTAGGATAAAACGAAA GGCT CAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGC AATG GTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTT GCAG TGTCGAAAGAAACAAAGTAGCCTGGCATCACCTAAAAATTATAAATAAATTAATAAACTT TTAT TAAAAAAAAATTACAAAATGAATAATCCACAAACAGGACAATCAACAGGCCTCTTGGGCA ATCG TTGGTTCTACTTGGTATTAGCAGTTTTGCTGATGTGTATGATCTCGGGTGTCCAATATTC CTGG ACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACG GCTT TCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATA AATT CGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCAT GGGT ATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGT ATCG TTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTT CCGG TTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGT TCTG AAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTTTGATCATGGGTATCCTGATT ATCC TGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTA CCGA CAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAATTCTGGGTTCTGTGGACCGC ATTC TTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGC CTCG GTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTT GCCG TCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTT CGGT ATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTT ATCG CCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCA ACAG CGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGC AACT GCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAACCAACTTCGGATGGAATACC GCTT TCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAA GAAT GGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAAGAAAAAGCTGTACATTAAGG TTCC TAACCTGCCTGGCATCTTAATCAATTTTAAACTCACCAAATCAAAATATGAAAAAAAAAA ATAA TAAAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGG CCCA TCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGC GTTG GTGACGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTTTACTTCACCA TGCT TAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAAT GGAA AAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCAC ATGG GCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAG GGTT TGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGG TGGC GCGGCATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGT GACA GCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAA CGGG GCGTGGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAA ATTA CGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAAT GGTA CATTTGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGA TCCT GAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTATTCAGGAGCA AAAC TGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCCGGCATACAGT ACAG CCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCA CTAT TGATAAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTT AAGT ATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAA CAAC CGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGG ATAT TAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAG CGAC GATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTAAACGACCTGGCAT CAAC TACCTTTATTATTCAACAAACCAATTTAACATATTAAAAAAATAAAAAAATGACTACCAC AGCA ACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCGGCATAGTA GGTA TTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTATACCGTGTC GCAA TGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAACCTGGTGT CCTG TTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATAGTATGTCG AACC GCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAAGGGAGGTT TCCA GGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAACTGACGCC GGAT AACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCGCCGGAGTG AGCT ATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAATGATAGAA CTGG TAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGTAAAATTAA GAAG GTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAGGTAAAGGA GCAG TGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTTCCTTCCGA CTCC CATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCCCGGAGCCA GGCT CTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCCTTCACTTC GGAA CGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCCGGAAACGC TCGG AGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGACTATCGGT TACT GCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAGTCAAACAG GAGA TCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAACGCGTGGAG CTCA GCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTATCGCACGAT CTTG GTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTGATGCACCT CGCA GAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGCATTAGCGT GTAA AGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTCGGTTTTAG CGCT ATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAATGAATAAC TCTG GGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTTGTCAAAAA ATTG TAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAATACCATCTC AGAG TTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAACCTCCGTC ATTA ATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAACAAGCCTA GACT GTAAGGTTCCTAATTCCCCTGGCATCAACTACCTAAATTACTTATCAAACCACTTAGTAG TAAA AAAAATATAACAAAATGACAAATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTA TCGA TATGACACATGTCCTTAATGGACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAG GGTA ATTAAAGTTGAGCCGCCGGGTCATGGTGATGATACCCGCACATTTGGTCCCTATGTGGAT GGAC AGTCACTCTATTACAGTTTTATTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGA ATGA TCACGATAAAAGTATATTTATAAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTT TCGC CCAGGTACAATGGAAAAACTGGGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGC CTCA TATATGCTTCATCGTCAGGTTTCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACG ATAC CATCATTCAGGCAATGAGCGGGATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGT GCGC GTTGGTACATCTCTTGCGGATCTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGT GCAC TTTATGGCCGCGAAAAGAGCCAGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCA CGCT GAGTTTTCTGGAGCATGGTCTGATGGCATATATCGCAACTGGGAAGTCACCACAACGTCT GGGA AATCGCCATCCCTACATGGCACCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACG ATTT GTTGTGGTAATGACAAGCTTTTTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGG TTAA TGATCCCCGATTTAGCAGCAATATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATA TATT GAGCGGACGTTAAAAACGCAGGCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGT GTAC CCGTCGCGCCGTTATTAAGTGTGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAA ATAT GTTGATTGAAGCCGGGGGAATAATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGC GGAC CCGCATGTTATGCCGGGAGCGGCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAG TTCT CATCATAAGGTTCCTAAAATGCCTGGCATCTTTTCCATAACAAAAATTAAACCTCCTCCA TATG AAAAATAAAAATTATAAAATGACAAGTGCCGCTACTGTTACTGCTTCGTTCAACGATACT TTTA GCGTATCCGATAATGTCGCCGTTATTGTTCCTGAAACGGACACTCAGGTGACCTACAGGG ATCT ATCCCACATGGTGGGTCACTTCCAGACCATGTTCACAAATCCTAATTCTCCATTGTACGG AGCT GTTTTCAGACAAGATACAGTGGCGATATCCATGCGTAATGGGCTGGAATTTATCGTCGCT TTCC TCGGTGCTACTATGGACGCTAAAATTGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGG AGTT CAATTTTTATTTGAATGACCTGAAATCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAA GTTA CAGAGTTCTGAAATTCTAAAATCTGCCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCC TTCG ATGCGACCAGGTTTAGGGTAGAGTATGATATATACTCTCCAGAGGACAACTACAAAAGGG TTAT TTACCGGTCTTTGAACAACGCCAAATTTGTCAACACAAATCCCGTTAAATTCCCTGGGTT TGCC CGTTCCAGTGACGTTGCCCTGATTTTGCATACCAGTGGTACCACCTCCACTCCAAAAACG GTGC CTTTGTTACATTTGAACATTGTGAGAAGCACGTTGAACATTGCTAACACTTACAAGCTAA CGCC CTTGGACAGATCTTATGTCGTGATGCCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTT ACTT TCCACTTTTAGAACTCAGGGTTCTGTTGTGGTTCCCGATGGATTCCATCCAAAGTTATTC TGGG ACCAATTTGTTAAGTACAACTGTAATTGGTTCAGTTGCGTTCCCACAATAAGCATGATTA TGCT GAACATGCCCAAACCAAACCCTTTCCCACACATTAGATTCATCAGATCGTGTTCTTCTGC TTTG GCTCCAGCAACGTTCCATAAGCTGGAGAAGGAATTCAATGCACCTGTCTTGGAGGCCTAT GCGA TGACCGAAGCATCACATCAAATGACCTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTG GTAC TGTGGGCCAGCCACAAGGAGTCACCGTCGTCATTCTAGATGACAATGACAATGTCTTGCC CCCG GGCAAAGTCGGCGAAGTTTCCATCAGAGGCGAAAACGTCACTTTGGGGTATGCTAATAAT CCAA AAGCTAACAAGGAGAACTTCACCAAGAGAGAGAACTATTTCAGAACCGGTGACCAAGGTT ATTT CGACCCTGAGGGGTTTTTGGTCCTTACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGG TGAA AAGATTTCACCCATTGAGCTCGACGGCATTATGCTATCGCATCCAAAGATCGATGAAGCC GTTG CATTTGGTGTTCCCGACGATATGTACGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGA AGGG AGAAAAAATGACCTACGAAGAACTGGTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAA AATT CCAACCAAGGTGTACTTTGTTGATAAGCTACCAAAAACCGCTACAGGTAAAATCCAGAGA AGAG TTATCGCAGAAACTTTTGCTAAGAGCAGCAGAAATAAGAGTAAGTTGTAGGGTTCCTAAA AACC CTGGCATCTAAACTAAAATACAATAACCAAAAATCATTACAAATGAAAAAAAATAATAAA ATGG ATAGCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCCCGATCGCCGAG CTCT CTCCGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTAATCGAACGCGC CGCT TCACGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTCTCACCTTCCCT AACA CCGTCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCACGGCGGCGCCGT TGAA CGCAGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGATTCAAAGCTATT GTTA ACCTCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGAAAATCTCTCAC GTCA CCGCTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGATTCAGATTCCG TCGT TGACTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTCCTCCACACTTC TGGC ACTACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTTCATCCGTCAAG AACA TTAAAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCTCCCTCTGTTCC ATGT TCATGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCTGTAACTCTTCC AGCT GCTGGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATAACGCTACATGG TATA CTGCTGTGCCGACCATTCATCAGATCATATTGGACCGCCACGCGAGCCACCCTGAAACGG AATA TCCTAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTGATATTGTCCAG GCTT GAGGAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGGCAACACATTTG ATGA GCTCAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGGGAAACCGGTAG GTCA AGAAATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAACAAAGGAGAGGT TTGT ATAAGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCAACAAGGCAGGT TTCG AGTTTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGATACCGATGGGTATTTGCATC TGGT GGGTCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCAATTGAAGTGGA TGCA GTACTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTCCTGATGAGAAA TATG GGGAAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAACCGAAGAGGACA TTAA AGCGTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTGTTCATCACTGA TAAC CTCCCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAACATTTCCTTGAG AAGC CCTGAGGTTCCTAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTCTGT TGTG TCTTCTTTTAGGTGTGGAATAATTTTCCAACCATCACTTTATCTGTCTCCCGAACAGCAC CTTA TTCAGCCATCGGTTCACATACACGTTCACGAAAGCACATCCTACTCCGATAGCGGCTCCT GCCA CTACATCACTGGGATAGTGCACCCCTTGGTTCATCCGGGCAAACCCTACTCCGCAAGCCC ATAC GGCTGAAGGGGCGATAACATACCACTTAGGATAAGTGATGGAGAGTGAGGTGGCTAAAGA AAAA GCTGCCGCAGTGTGTCCTGAAGGGAATGACGGACTATCGGCATCCGGTGCTCCGTATGCA TGAA TCTTATCCGGATACTTTACAAAAGGCCGGTCACGACCTATTATATGTTTGGCGGCGTATG TAAT CCCCACTGCTTCAATCACACTGGTTCCTATGTAAATGGCATCTTTCAGCATCGGCTGGTC TTTC TTTATCAATGCATAGAGTCCCATGGCTGTAGGTATTCCTACGGGTAGAATCACTCCGCTA GCGG ACAATCCGCGGCTCAGTCCGTGTACATCCCATCGGTTGATGGTTTTCAACGTGTTGATGT CTAT ATTCTGTGCGCTGAGGCTGAATGTAAAACAGGCTGTCAGTATAAGAAAAATAATCCTTTG GCGT TTCATTTAGTTTGGCATTTGTTCAGTGCAAAGATAGGAAAATAATGTAATTCGCATTTAC CCTT CCCCGAATTAAAGAATAATTTCCATAATTCCTTGTATTATCGCTAGAATTCCTTTACTTT TGCA TCGTGAATACACAGCTTTTAACAGAATTTTTAGTTCTAACAATTAAATAATTTAAATTCA ATCA TTTATGTGGTTAAGTAATTCATCTATTGGAAGGAAAGTGGTGATGAGTGTCACAGGTATC GCCC TTGTCCTGTTTCTGACGTTTCACATGGCGATGAACCTTGTTGCGCTCTTCTCGGAAGATG CTTA CAACATGATTTGTGAATTCTTGGGAGCTAACTGGTACGCGTTGGTTGCAACTGCCGGGCT GGCT GCTCTGTTTGTAATTCACATCATCTACGCTTTCTGGTTGACCATGCAGAACCGTGCAGCT CGCG GTAGCGAACGTTATGCAGTGAACGTTAAACCTAAAACTGTGGAATGGGCATCTCAGAACA TGCT TGTCCTGGGTATTGTCGTTATTGCCGGATTGGCTCTTCATTTTGCCAATTTCTGGTACAA AATG CAGTTTGCCGAAATTATCGGTGTTCATGATTTGGGCGCATTCGGTCCTACAGACGGTGCC GCTT ACATTCGTGAAACATTCGGATGCCCTGTATTTACAGTGCTTTACCTCATTTGGTTAGCAG CTTT GTGGTTCCACCTGACTCACGGATTCTGGAGTGCTTTGCAGACTTTGGGCTGGAGCAATAA AATC TGGTTCGAGCGTTGGAAGACTATTGGTAACATCTACTCTACTTTGGTAGTTCTTGGTTTT GCAG CAGTAGTCGTTATCTACTTCGCTATGACTGGCGCGCCTGATAGGTGGGCTGCCCTTCCTG GTTG GCTTGGTTTCATCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGC CTCG CAGAGCAGGATTCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACA CCCG CTCGCGGGTGGGCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGA AAGT CTACACGAACCCTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAA AAAT CGCTATAATGACCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCGGGGAT TGGT GAACAAAAAGGTGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGATATTGA GGTA TCATTTTATCGTAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAAATTTT AGCA TTTTGTAAAAAAGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTTGCATC CCGA AGAGTTTCTCTTAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTTTATGT CGTA AAGAGGGGCTTTGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTAGTTGA AACA CATAGAAAGTTGCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTACGTTC TTTT CTCAAAAAACATAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAATGAAC AAAG TAAATATAAAAGATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAATAATGA ATTG CATAAGTTTAGATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCATTTTAC TGCT GGATTGGTAAAGAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTATGTGAG GTAA CTCGTAATAAGCTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACTGAAAT TTAC ATTTCCTAGCCACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGCACAAA TATA ATTCGAAAAATTGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAATATGGT TTTG CTAAAATGTTATTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGTAGATA TTTC TATATTAGCAAAAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGCACATT AATT GTATTAAAAAGAAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAACTTTT GTAA TGAAATGGGTTAACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAAAGCTT TAAA ACATGCGAGAATATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTATTTAA TAGT TATAAAATATTTAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTACGCGGG TACC GACACCGCGGTGGAGGGGAATTGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACT CATC GAGCATCAAATGAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAA AAGC CGTTTCTGTAATGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGG TATC GGTCTGCGATTCCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAA TAAG GTTATCAAGTGAGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTT ATGC ATTTCTTTCCAGACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCA TCAA CCAAACCGTTATTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAA AAGG ACAATTACAAACAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAAT ATTT TCACCTGAATCAGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTG GTGA GTAACCATGCATCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATT CCGT CAGCCAGTTTAGTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATG TTTC AGAAACAACTCTGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGC CCGA CATTATCGCGAGCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCG GCCT GGAGCAAGACGTTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTA AGCA GACAGTTTTATTGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTT TGAG ACACAACGTGGCTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGAGCCTAC GTTC CGAATACGGTCAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTC GAAT TCTTTTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTC AGGT TTGTGATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATAC CATT TGATTCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTG TTTA CAGAACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGT TCAG CAAACGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGG CAAA GAGCAGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTC TACC TGATGGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGA CAGA TGATGCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTG TACG CAATACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATG ATCT TCGGCAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCA ATGC TGAATCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGC GTGT ACCGAGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTG ACTT TCAAACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGT CTCA TGCCGACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAA TGGC TCCCTTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTG TAAG GCTTCCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGG CCCC GTTAAACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGC ACAT CCGGTGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTG AAAG TTCAAGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAG GTAG CCCAATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTACAGTC GCTC GGCGATCGAAGGCTTCGGAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATG CCGC TTCGAATTCTTTTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTG ATAT TTCAGGTTTGTGATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTG TCTA TACCATTTGATTCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGC CGGT GTGTTTACAGAACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGC ACTT GGTTCAGCAAACGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATT TCTT TGGCAAAGAGCAGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACA GCGC TTCTACCTGATGGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACG TCCC GGACAGATGATGCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAA GTAT GTGTACGCAATACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTG CCGG ATGATCTTCGGCAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACC TTCG GCAATGCTGAATCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGC GGGT GGCGTGTACCGAGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGT TGTC CTGACTTTCAAACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTC ATTC AGTCTCATGCCGACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAG TCGT TAATGGCTCCCTTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGG AGGC GTGTAAGGCTTCCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTT TTAG CGGCCCCGTTAAACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACC GGAA AGCACATCCGGTGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACA TTAT TTGAAAGTTCAAGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAA AAAA AAGGTAGCCCAATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCC TAGG ATCAGCTGTACGTACTCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCATGTTTC ACGT ACTAAGCTCTCATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTCATGGC TAAC GTACTAAGCTCTCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATG TTTG AACAATAAAATTAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTTTATAA GAAA AAAAAGAATATATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACAAGCCA GGGA TGTAACGCACTGAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGGAACAC TTAA CGGCTGACATGGGGCGGCCGCGTAG [00251] SEQ ID NO: 95 (Ribosome binding site and At_AAE3 open reading frame):

GGAGAGCTGTATGTGGGGTGGAAGAAGCTATCGTAAAAATGCTGGAGCAGCTTGATC CTCATTC TACCTATTCTGATCCGGAGGAAGTGAAGAGAATGAACGAGCCGTTGCAGGGAAACTTCGA AGGT ATCGGTATACAGTTTAATATGGCGGAGGACACTTTGCTGGTGATACAGCCTGTATCGGGC GGAC CGTCCGAAAAAGTCGGTATTCTGGCCGGTGATCGTATCGTCATGGTGGAAGATACGCTGA TAGC CGGTGTAAAGATGAGTACCGAGGATATTATGCGTCGCCTCCGTGGTCCTAAAGATTCAAA AGTG AATCTGAAAATACTTCGCCGAGGGGTGAAGGAACTGCTCCCCTTTACGGTGAAAAGGGAT AAAA TACCTGTTTACAGCTTGGATGCTTCCTATATGATTAAAGATAAGATCGGTTATATTCGTA TCAA CCGTTTTGCCGCCACTACCCATGAGGAGTTCAAGAAAGCGCTGACCGGGTTGCAGAAGAA AGGA ATGAAAGACTTGATTCTTGATTTGCAGGGCAATGGCGGGGGGTATTTGAATGCTGCTATC GATA TTGCCAATGAATTTTTGGGTAAAAAGGAACTGATTGTCTATACGGAGGGCCGTCGTAATC CTCG TAGCGAGTTTTTTGCCAAAGGTACGGGCGAGTTTCAGAACGGTCGTCTGATGGTATTGGT TGAT GAATTTTCGGCTTCTGCCAGTGAGATTGTGACCGGAGCTGTTCAGGATTGGGACAGAGGC GTTG TGGTAGGCCGTCGCAGTTTTGGTAAAGGCTTGGTGCAGCGTCCCATTGATTTGCCGGACG GTTC GATGATCCGTCTGACGGTGGCCCGCTATTATACGCCTGCCGGACGTTGTATCCAGAAACC TTAC GAGAGCATTGAAAAGTATAATGAAGACCTGATAGACCGTTATAATAAAGGAGAAATGATG AGTG AAGACAGCATCCACTTTCCGGATTCACTGAAGTTCAAGACTCATAGGTTGGCCCGTACGG TATA TGGTGGCGGAGGGATCATGCCCGATTATTTTGTGCCGATTGATACGACTCTCTATACTAA ATAC CATCGTCAGTTGCGTGATAAAGGAGCATTGATGAAAGCTCATTTCCATTTTATTGATGCC CATC GTAAAGAATGGCTGGGCAAATACAAGACTTTCAATGAGTTCTACAAACGTTTTGAAGTGA CTCC GGATATGTTGACACAACTGGTTGCTACCGGCAAGGAGATGGGAGTGGAATATAATGAAGA AGAG TATCAAAAGGCCCTGCCTCTGCTGAGGTTGCAGATGAAAGCATTGATAGCCCGTGATTTA TGGG ATATGAATGAATATTATCACGTCATTAATGACGCGAATGAAAGTATCAGGAAAGCGCTGG AACT GTTGGAGCAACCGGACTTTGAGGGGCTGCTGTTGAAAAAGCGATAGTCAAGACTTTATAT TAAC TGCAGGGGCGCATAGTTGCACTCCTGCAGTTGTCTGAAAAACTTGTAGGATAAAACGAAA GGCT CAGTCGAAAGACTGGGCCTTTCGTTTTACAATTGGGCTACCTTTTTTTTGTTTTGTTTGC AATG GTTAATCTATTGTTAAAATTTAAAGTTTCACTTGAACTTTCAAATAATGTTCTTATATTT GCAG TGTCGAAAGAAACAAAGTAGCCTGGCATCATCTACCTTCATTATTAATCATTCCAATTGT ATCA CTTAAAAATATAAAAAAATGTCAACTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCG GTGT GCAATCTGGCCCATCTTGTACTCAAATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAAT TGAA CGTCCCGGCGTTGGTGACGTAACGCGTCACCAGCTGCGAGATATTCCTGATATCGATGCG CTTT ACTTCACCATGCTTAACAGTAACAAACGTTCTATTGAGTTAAATACCAAAACAGCGGAAG GCAA AGAGGTAATGGAAAAGCTGATCCGCGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGG GGCC ATTGATCACATGGGCTTCACCTGGGAGCATATTCAAGAAATCAATCCACGTCTGATTTTT GGTT CGATCAAAGGGTTTGATGAGTGTTCGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTG CTCA GGCAGCGGGTGGCGCGGCATCCACTACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGC TGCA GCGTTGGGTGACAGCAACACCGGAATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTG CATC GCGAAAAAACGGGGCGTGGGCAACGAGTCACCATGTCAATGCAGGATGCCGTATTGAACC TTTG CCGCGTGAAATTACGTGACCAGCAGCGTCTAGATAAATTGGGTTATCTGGAAGAATACCC GCAG TATCCGAATGGTACATTTGGTGATGCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGT CAGC CTGGCTGGATCCTGAAATGTAAAGGCTGGGAAACCGATCCTAACGCCTATATTTATTTCA CTAT TCAGGAGCAAAACTGGGAAAACACCTGTAAAGCCATCGGCAAACCAGAATGGATTACCGA TCCG GCATACAGTACAGCCCATGCACGACAGCCACATATTTTCGATATTTTTGCTGAAATCGAA AAAT ACACTGTCACTATTGATAAACATGAAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTT GTGC ACCGGTTTTAAGTATGAAAGAAATTTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGT TGTT GAAGTGGAACAACCGTTGCGTGGAAAATATCTGACCGTTGGTTGTCCAATGAAATTCTCT GCCT TTACGCCGGATATTAAAGCTGCGCCGCTATTAGGTGAACATACCGCTGCTGTATTGCAGG AGCT GGGTTATAGCGACGATGAAATTGCTGCAATGAAGCAAAACCACGCCATCTGAGGTTCCTA ACCT GCCTGGCATCAACTACCTAAATTACTTATCAAACCACTTAGTAGTAAAAAAAATATAACA AAAT GACAAATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTATCGATATGACACATGT CCTT AATGGACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAGGGTAATTAAAGTTGAG CCGC CGGGTCATGGTGATGATACCCGCACATTTGGTCCCTATGTGGATGGACAGTCACTCTATT ACAG TTTTATTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGAATGATCACGATAAAAG TATA TTTATAAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTTTCGCCCAGGTACAATG GAAA AACTGGGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGCCTCATATATGCTTCAT CGTC AGGTTTCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACGATACCATCATTCAGGC AATG AGCGGGATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGTGCGCGTTGGTACATCT CTTG CGGATCTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGTGCACTTTATGGCCGCG AAAA GAGCCAGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCACGCTGAGTTTTCTGGA GCAT GGTCTGATGGCATATATCGCAACTGGGAAGTCACCACAACGTCTGGGAAATCGCCATCCC TACA TGGCACCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACGATTTGTTGTGGTAATG ACAA GCTTTTTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGGTTAATGATCCCCGATT TAGC AGCAATATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATATATTGAGCGGACGTTA AAAA CGCAGGCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGTGTACCCGTCGCGCCGT TATT AAGTGTGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAAATATGTTGATTGAAGC CGGG GGAATAATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGCGGACCCGCATGTTATG CCGG GAGCGGCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAGTTCTCATCATAAGGTT CCTA AACGACCTGGCATCATCTACCTTCATTATTAAACAAACCAAATTAATATCATAAAAAAAT AAAA AAATGACTACCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATA CTGT CTTCGGCATAGTAGGTATTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAAT TAAG TTTATACCGTGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATC TCGG ACAAACCTGGTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGA TCTA TAATAGTATGTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGA CATC CACAAGGGAGGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTC ACTG GTAAACTGACGCCGGATAACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTC AGGG AACCGCCGGAGTGAGCTATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCT TGAG GGCAATGATAGAACTGGTAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCA GACC CCAGTAAAATTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAA TAGT GATAGGTAAAGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAA CTTG CCGTTCCTTCCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTG AGCA GCGCCCGGAGCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGA ATTG GATCCTTCACTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGA CAGT AACCCGGAAACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGG GACA TCGGACTATCGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAAT ACTC GGGAGTCAAACAGGAGATCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAA GGAA AAAACGCGTGGAGCTCAGCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATT GACG ACTATCGCACGATCTTGGTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTT TTCC GACTGATGCACCTCGCAGAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTT AGGT TACGCATTAGCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGAC AGTG CCTTCGGTTTTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGA TTGT CGTAATGAATAACTCTGGGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCC GACC GCTTTGTCAAAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTC TTCG TCAATACCATCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCA AGCG CGAAACCTCCGTCATTAATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGC ATGG CAAAACAAGCCTAGACTGTAAGGTTCCTAAGGGTCCTGGCATCCCCAAAAAATTAATTCA TTTT CTCTTTTCCCTAACCCTTAAAATATAATAAAATGAGTAACGACGACAATGTAGAGTTGAC TGAT GGCTTTCATGTTTTGATCGATGCCCTGAAAATGAATGACATCGATACCATGTATGGTGTT GTCG GCATTCCTATCACGAACCTGGCTCGTATGTGGCAAGATGACGGTCAGCGTTTTTACAGCT TCCG TCACGAACAACACGCAGGTTATGCAGCTTCTATCGCCGGTTACATCGAAGGAAAACCTGG CGTT TGCTTGACCGTTTCCGCCCCTGGCTTCCTGAACGGCGTGACTTCCCTGGCTCATGCAACC ACCA ACTGCTTCCCAATGATCCTGTTGAGCGGTTCCAGTGAACGTGAAATCGTCGATTTGCAAC AGGG CGATTACGAAGAAATGGATCAGATGAATGTTGCACGTCCACACTGCAAAGCTTCTTTCCG TATC AACAGCATCAAAGACATTCCAATCGGTATCGCTCGTGCAGTTCGCACCGCTGTATCCGGA CGTC CAGGTGGTGTTTACGTTGACTTGCCAGCAAAACTGTTCGGTCAGACCATTTCTGTAGAAG AAGC TAACAAACTGCTCTTCAAACCAATCGATCCAGCTCCGGCACAGATTCCTGCTGAAGATGC TATC GCTCGCGCTGCTGACCTGATCAAGAACGCCAAACGTCCAGTTATCATGCTGGGTAAAGGC GCTG CATACGCACAATGCGACGACGAAATCCGCGCACTGGTTGAAGAAACCGGCATCCCATTCC TGCC AATGGGTATGGCTAAAGGCCTGCTGCCTGACAACCATCCACAATCCGCTGCTGCAACCCG TGCT TTCGCACTGGCACAGTGTGACGTTTGCGTACTGATCGGCGCTCGTCTGAACTGGCTGATG CAGC ACGGTAAAGGCAAAACCTGGGGCGACGAACTGAAGAAATACGTTCAGATCGACATCCAGG CTAA CGAAATGGACAGCAACCAGCCTATCGCTGCACCAGTTGTTGGTGACATCAAGTCCGCCGT TTCC CTGCTCCGCAAAGCACTGAAAGGCGCTCCAAAAGCTGACGCTGAATGGACCGGCGCTCTG AAAG CCAAAGTTGACGGCAACAAAGCCAAACTGGCTGGCAAGATGACTGCCGAAACCCCATCCG GAAT GATGAACTACTCCAATTCCCTGGGCGTTGTTCGTGACTTCATGCTGGCAAATCCGGATAT TTCC CTGGTTAACGAAGGCGCTAATGCACTCGACAACACTCGTATGATTGTTGACATGCTGAAA CCAC GCAAACGTCTTGACTCCGGTACCTGGGGTGTTATGGGTATTGGTATGGGCTACTGCGTTG CTGC AGCTGCTGTTACCGGCAAACCGGTTATCGCTGTTGAAGGCGATAGCGCATTCGGTTTCTC CGGT ATGGAACTGGAAACCATCTGCCGTTACAACCTGCCAGTTACCGTTATCATCATGAACAAT GGTG GTATCTATAAAGGTAACGAAGCAGATCCACAACCAGGCGTTATCTCCTGTACCCGTCTGA CCCG TGGTCGTTACGACATGATGATGGAAGCATTTGGCGGTAAAGGTTATGTTGCCAATACTCC AGCA GAACTGAAAGCTGCTCTGGAAGAAGCTGTTGCTTCCGGCAAACCATGCCTGATCAACGCG ATGA TCGATCCAGACGCTGGTGTCGAATCTGGCCGTATCAAGAGCCTGAACGTTGTAAGTAAAG TTGG CAAGAAATAAGGTTCCTAATTCCCCTGGCATCTAAACTAAAATACAATAACCAAAAATCA TACT ACATGTATAAAATTAAAAAAATGGATAGCGATACTCTCTCAGGATTATTGGAAAACGTCG CCAA AAAATTCCCCGATCGCCGAGCTCTCTCCGTTTCTGGAAAATTCAATCTCACTCACGCGCG TCTT CACGATCTAATCGAACGCGCCGCTTCACGCCTTGTCTCCGACGCTGGAATCAAACCCGGC GATG TCGTTGCTCTCACCTTCCCTAACACCGTCGAGTTTGTTATAATGTTTTTAGCGGTGATAA GAGC TAGAGCCACGGCGGCGCCGTTGAACGCAGCGTACACGGCGGAGGAATTTGAGTTTTACCT CTCC GATTCAGATTCAAAGCTATTGTTAACCTCTAAAGAAGGAAACGCACCGGCTCAAGAAGCA GCTT CAAAGCTGAAAATCTCTCACGTCACCGCTACGCTGCTTGACGCTGGCTCGGACCTTGTAC TATC CGTTGCGGATTCAGATTCCGTCGTTGACTCAGCGACGGAACTCGTTAATCACCCGGACGA CGGT GCTCTCTTCCTCCACACTTCTGGCACTACGAGCCGTCCAAAGGGTGTACCGCTTACGCAG CTCA ATCTAGCTTCATCCGTCAAGAACATTAAAGCTGTGTACAAGCTTACTGAGTCTGATTCTA CGGT GATTGTTCTCCCTCTGTTCCATGTTCATGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGG AGCT GGTGCTGCTGTAACTCTTCCAGCTGCTGGTAGATTCTCAGCAACAACATTTTGGCCAGAT ATGA AGAAGTATAACGCTACATGGTATACTGCTGTGCCGACCATTCATCAGATCATATTGGACC GCCA CGCGAGCCACCCTGAAACGGAATATCCTAAACTCCGGTTCATCAGGAGTTGCAGTGCTTC TTTG GCTCCGGTGATATTGTCCAGGCTTGAGGAAGCGTTTGGAGCACCGGTGCTCGAGGCCTAT GCAA TGACAGAGGCAACACATTTGATGAGCTCAAACCCCTTACCAGAGGAAGGTCCACACAAGC CTGG GTCTGTTGGGAAACCGGTAGGTCAAGAAATGGCGATCCTTAATGAGAAAGGCGAGATCCA AGAG CCAAATAACAAAGGAGAGGTTTGTATAAGAGGTCCAAATGTGACCAAGGGTTACAAGAAT AACC CAGAAGCCAACAAGGCAGGTTTCGAGTTTGGGTGGTTCCACACTGGTGATATCGGTTACT TTGA TACCGATGGGTATTTGCATCTGGTGGGTCGGATCAAAGAGCTTATTAACCGTGGAGGTGA GAAG ATATCTCCAATTGAAGTGGATGCAGTACTCTTAACGCATCCTGACGTTTCTCAGGGTGTT GCAT TCGGTGTTCCTGATGAGAAATATGGGGAAGAGATTAACTGTGCGGTGATTCCAAGAGAAG GAAC TACTGTAACCGAAGAGGACATTAAAGCGTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGT GCCA AAGAGAGTGTTCATCACTGATAACCTCCCCAAAACTGCCTCTGGTAAGATTCAGCGCCGT ATCG TCGCACAACATTTCCTTGAGAAGCCCTGAGGTTCCTAAAATGCCTGGCATCAACTACCTC AATT AATAATCAAACCATCTGAACAATGAATAAATTTAAAAAAATGACAAGTGCCGCTACTGTT ACTG CTTCGTTCAACGATACTTTTAGCGTATCCGATAATGTCGCCGTTATTGTTCCTGAAACGG ACAC TCAGGTGACCTACAGGGATCTATCCCACATGGTGGGTCACTTCCAGACCATGTTCACAAA TCCT AATTCTCCATTGTACGGAGCTGTTTTCAGACAAGATACAGTGGCGATATCCATGCGTAAT GGGC TGGAATTTATCGTCGCTTTCCTCGGTGCTACTATGGACGCTAAAATTGGCGCGCCCTTGA ATCC CAATTATAAGGAAAAGGAGTTCAATTTTTATTTGAATGACCTGAAATCTAAGGCGATTTG CGTC CCAAAGGGTACCACAAAGTTACAGAGTTCTGAAATTCTAAAATCTGCCTCCACGTTTGGA TGTT TTATCGTAGAGCTGGCCTTCGATGCGACCAGGTTTAGGGTAGAGTATGATATATACTCTC CAGA GGACAACTACAAAAGGGTTATTTACCGGTCTTTGAACAACGCCAAATTTGTCAACACAAA TCCC GTTAAATTCCCTGGGTTTGCCCGTTCCAGTGACGTTGCCCTGATTTTGCATACCAGTGGT ACCA CCTCCACTCCAAAAACGGTGCCTTTGTTACATTTGAACATTGTGAGAAGCACGTTGAACA TTGC TAACACTTACAAGCTAACGCCCTTGGACAGATCTTATGTCGTGATGCCTCTTTTCCACGT CCAT GGGTTAATTGGTGTTTTACTTTCCACTTTTAGAACTCAGGGTTCTGTTGTGGTTCCCGAT GGAT TCCATCCAAAGTTATTCTGGGACCAATTTGTTAAGTACAACTGTAATTGGTTCAGTTGCG TTCC CACAATAAGCATGATTATGCTGAACATGCCCAAACCAAACCCTTTCCCACACATTAGATT CATC AGATCGTGTTCTTCTGCTTTGGCTCCAGCAACGTTCCATAAGCTGGAGAAGGAATTCAAT GCAC CTGTCTTGGAGGCCTATGCGATGACCGAAGCATCACATCAAATGACCTCAAACAATCTGC CTCC AGGAAAGAGAAAGCCTGGTACTGTGGGCCAGCCACAAGGAGTCACCGTCGTCATTCTAGA TGAC AATGACAATGTCTTGCCCCCGGGCAAAGTCGGCGAAGTTTCCATCAGAGGCGAAAACGTC ACTT TGGGGTATGCTAATAATCCAAAAGCTAACAAGGAGAACTTCACCAAGAGAGAGAACTATT TCAG AACCGGTGACCAAGGTTATTTCGACCCTGAGGGGTTTTTGGTCCTTACAGGCAGAATCAA AGAG CTTATCAACAGGGGTGGTGAAAAGATTTCACCCATTGAGCTCGACGGCATTATGCTATCG CATC CAAAGATCGATGAAGCCGTTGCATTTGGTGTTCCCGACGATATGTACGGCCAAGTAGTTC AAGC CGCCATTGTTTTGAAGAAGGGAGAAAAAATGACCTACGAAGAACTGGTGAACTTCTTAAA GAAG CACCTAGCCTCTTTCAAAATTCCAACCAAGGTGTACTTTGTTGATAAGCTACCAAAAACC GCTA CAGGTAAAATCCAGAGAAGAGTTATCGCAGAAACTTTTGCTAAGAGCAGCAGAAATAAGA GTAA GTTGTAGGGTTCCTAAAAACCCTGGCATCACCTAAAAATTATAAATAAATTAATAAACTT TTAT TAAAAAAAAATTACAAAATGAATAATCCACAAACAGGACAATCAACAGGCCTCTTGGGCA ATCG TTGGTTCTACTTGGTATTAGCAGTTTTGCTGATGTGTATGATCTCGGGTGTCCAATATTC CTGG ACACTGTACGCTAACCCGGTTAAAGACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACG GCTT TCACACTCTCTCAGGTCATTCAAGCTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATA AATT CGGTCCAAGAATTCCATTGATGTTCGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCAT GGGT ATGGTTGACAGTGTTCCTGCTCTGTATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGT ATCG TTTACGGTATCGCGATGAACACGGCTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTT CCGG TTTCACCGCTGCCGGTTACGGTCTGGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGT TCTG AAAGTTGAAGGTGTTGGCGCAGCATTCATGTACACCGGTTTGATCATGGGTATCCTGATT ATCC TGATCGCTTTCGTTATCCGTTTCCCTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTA CCGA CAAGGATTTCAATTCTGGCGAAATGCTGAGAACACCACAATTCTGGGTTCTGTGGACCGC ATTC TTTTCCGTTAACTTTGGTGGTTTGCTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGC CTCG GTCTTGCCGCAGGTGTGCTGACGATCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTT GCCG TCCTTTCTGGGGTTTCGTTTCCGATAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTT CGGT ATCAATGCTGTTGTTCTCGCACTTTTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTT ATCG CCATGTTGGCAATCGCATTCTTCACATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCA ACAG CGATATTTTCGGTACGGCATACTCTGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGC AACT GCCTCGATCTTCGGTGGTGGTCTGGGTGCTGCAATTGCAACCAACTTCGGATGGAATACC GCTT TCCTGATTACTGCGATTACTTCTTTCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAA GAAT GGGCCGTCCAGTCAAGAAAATGGTCAAATTGTCTCCAGAAGAAAAAGCTGTACATTAAGG TTCC TAGCTGATTAGAAGGCCATCCTGACGGATGGCCTTTTTTTTGACTCTGTTGTGTCTTCTT TTAG GTGTGGAATAATTTTCCAACCATCACTTTATCTGTCTCCCGAACAGCACCTTATTCAGCC ATCG GTTCACATACACGTTCACGAAAGCACATCCTACTCCGATAGCGGCTCCTGCCACTACATC ACTG GGATAGTGCACCCCTTGGTTCATCCGGGCAAACCCTACTCCGCAAGCCCATACGGCTGAA GGGG CGATAACATACCACTTAGGATAAGTGATGGAGAGTGAGGTGGCTAAAGAAAAAGCTGCCG CAGT GTGTCCTGAAGGGAATGACGGACTATCGGCATCCGGTGCTCCGTATGCATGAATCTTATC CGGA TACTTTACAAAAGGCCGGTCACGACCTATTATATGTTTGGCGGCGTATGTAATCCCCACT GCTT CAATCACACTGGTTCCTATGTAAATGGCATCTTTCAGCATCGGCTGGTCTTTCTTTATCA ATGC ATAGAGTCCCATGGCTGTAGGTATTCCTACGGGTAGAATCACTCCGCTAGCGGACAATCC GCGG CTCAGTCCGTGTACATCCCATCGGTTGATGGTTTTCAACGTGTTGATGTCTATATTCTGT GCGC TGAGGCTGAATGTAAAACAGGCTGTCAGTATAAGAAAAATAATCCTTTGGCGTTTCATTT AGTT TGGCATTTGTTCAGTGCAAAGATAGGAAAATAATGTAATTCGCATTTACCCTTCCCCGAA TTAA AGAATAATTTCCATAATTCCTTGTATTATCGCTAGAATTCCTTTACTTTTGCATCGTGAA TACA CAGCTTTTAACAGAATTTTTAGTTCTAACAATTAAATAATTTAAATTCAATCATTTATGT GGTT AAGTAATTCATCTATTGGAAGGAAAGTGGTGATGAGTGTCACAGGTATCGCCCTTGTCCT GTTT CTGACGTTTCACATGGCGATGAACCTTGTTGCGCTCTTCTCGGAAGATGCTTACAACATG ATTT GTGAATTCTTGGGAGCTAACTGGTACGCGTTGGTTGCAACTGCCGGGCTGGCTGCTCTGT TTGT AATTCACATCATCTACGCTTTCTGGTTGACCATGCAGAACCGTGCAGCTCGCGGTAGCGA ACGT TATGCAGTGAACGTTAAACCTAAAACTGTGGAATGGGCATCTCAGAACATGCTTGTCCTG GGTA TTGTCGTTATTGCCGGATTGGCTCTTCATTTTGCCAATTTCTGGTACAAAATGCAGTTTG CCGA AATTATCGGTGTTCATGATTTGGGCGCATTCGGTCCTACAGACGGTGCCGCTTACATTCG TGAA ACATTCGGATGCCCTGTATTTACAGTGCTTTACCTCATTTGGTTAGCAGCTTTGTGGTTC CACC TGACTCACGGATTCTGGAGTGCTTTGCAGACTTTGGGCTGGAGCAATAAAATCTGGTTCG AGCG TTGGAAGACTATTGGTAACATCTACTCTACTTTGGTAGTTCTTGGTTTTGCAGCAGTAGT CGTT ATCTACTTCGCTATGACTGGCGCGCCTGATAGGTGGGCTGCCCTTCCTGGTTGGCTTGGT TTCA TCAGCCATCCGCTTGCCCTCATCTGTTACGCCGGCGGTAGCCGGCCAGCCTCGCAGAGCA GGAT TCCCGTTGAGCACCGCCAGGTGCGAATAAGGGACAGTGAAGAAGGAACACCCGCTCGCGG GTGG GCCTACTTCACCTATCCTGCCCGGCTGACGCCGTTGGATACACCAAGGAAAGTCTACACG AACC CTTTGGCAAAATCCTGTATATCGTGCGAAAAAGGATGGATATACCGAAAAAATCGCTATA ATGA CCCCGAAGCAGGGTTATGCAGCGGAAAAGCGGGATTAAAAGTCGGGGATTGGTGAACAAA AAGG TGTTTCTCTCTTTAAGAGAAATATCGTTTTGCTAAACAGTTGATATTGAGGTATCATTTT ATCG TAAAAGACATTTTTGCTCAACAATTGCTTGACGGAAATCAACAAATTTTAGCATTTTGTA AAAA AGTCGCTATATAATTTGGTGAATTGGAGTTATTTTCATATTTTTGCATCCCGAAGAGTTT CTCT TAAAGAGAGAAACATCTTTTGCATACCTTTTCCGACCGAATTTTTATGTCGTAAAGAGGG GCTT TGCAGGGGGTGGACTCAGAAAGATGAGAATAGATGACTATTGTAGTTGAAACACATAGAA AGTT GCTGATATACAGACCGATACGCATATCGGGATGAACCATGAGTACGTTCTTTTCTCAAAA AACA TAAATATTCGAAAAGAGATGCAATAAATTAAGGAGAGGTTATAATGAACAAAGTAAATAT AAAA GATAGTCAAAATTTTATTACTTCAAAATATCACATAGAAAAAATAATGAATTGCATAAGT TTAG ATGAAAAAGATAACATCTTTGAAATAGGTGCAGGGAAAGGTCATTTTACTGCTGGATTGG TAAA GAGATGTAATTTTGTAACGGCGATAGAAATTGATTCTAAATTATGTGAGGTAACTCGTAA TAAG CTCTTAAATTATCCTAACTATCAAATAGTAAATGATGATATACTGAAATTTACATTTCCT AGCC ACAATCCATATAAAATATTTGGCAGCATACCTTACAACATAAGCACAAATATAATTCGAA AAAT TGTTTTTGAAAGTTCAGCCACAATAAGTTATTTAATAGTGGAATATGGTTTTGCTAAAAT GTTA TTAGATACAAACAGATCACTAGCATTGCTGTTAATGGCAGAGGTAGATATTTCTATATTA GCAA AAATTCCTAGGTATTATTTCCATCCAAAACCTAAAGTGGATAGCACATTAATTGTATTAA AAAG AAAGCCAGCAAAAATGGCATTTAAAGAGAGAAAAAAATATGAAACTTTTGTAATGAAATG GGTT AACAAAGAGTACGAAAAACTGTTTACAAAAAATCAATTTAATAAAGCTTTAAAACATGCG AGAA TATATGATATAAACAATATTAGTTTCGAACAATTTGTATCGCTATTTAATAGTTATAAAA TATT TAACGGCTAAAAACAATAGGCCACATGCAACTGTAAATGTTTACGCGGGTACCGACACCG CGGT GGAGGGGAATTGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCATC AAAT GAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTTCT GTAA TGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTGC GATT CCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATCA AGTG AGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCTT TCCA GACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAACC GTTA TTCATTCGTGATTGCGCCTGAGCGAGGCGAAATACGCGATCGCTGTTAAAAGGACAATTA CAAA CAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCTG AATC AGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAACCA TGCA TCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCAG TTTA GTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAACA ACTC TGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTATC GCGA GCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTGGAGCAA GACG TTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAGTT TTAT TGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACAAC GTGG CTTTGTTGAATAAATCGAACTTTTGCTGAGTTGAAGGATCAGAGCCTACGTTCCGAATAC GGTC AAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAATTCTTTTA GGAA GCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGTTTGTGAT ACGC TCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATTTGATTCA AGTA CGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTACAGAACG GACA TCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAGCAAACGG GAAG TAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAAGAGCAGC AATA CCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACCTGATGGA AGAA ACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGATGATGCG GATA GGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACGCAATACT ACGT CCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCTTCGGCAA AGTT CAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGCTGAATCC CAGA CGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGTACCGAGT TCTA CAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTTTCAAACA TTTC TTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCATGCCGAC TTCT TTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGCTCCCTTC TTAC TTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAGGCTTCCA CCTC TTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCCGTTAAAC AAAA TTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACATCCGGTGA CAGC TCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAGTTCAAGT GAAA CTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAGCCCAATT GTAA AACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTACAGTCGCTCGGCGATC GAAG GCTTCGGAAAAAAAAGGCCATCCGTCAGGATGGCCTTCGCATTAATATGCCGCTTCGAAT TCTT TTAGGAAGCGTGTATCGTTTTCAGAGAACATACGGAGGTCTTTCACCTGATATTTCAGGT TTGT GATACGCTCGATACCCATACCGAGTCCATAACCGCTGTATATTTTGCTGTCTATACCATT TGAT TCAAGTACGTTCGGGTCTACCATACCGCAACCGAGGATTTCTACCCAGCCGGTGTGTTTA CAGA ACGGACATCCTTTACCGCCGCAGATATTACAGCTGATATCCATTTCCGCACTTGGTTCAG CAAA CGGGAAGTAAGACGGACGCAGACGGATCTTTGTATCAGCACCGAACATTTCTTTGGCAAA GAGC AGCAATACCTGCTTCAAGTCGGTGAATGATACGTTTTTATCTACATACAGCGCTTCTACC TGAT GGAAGAAACAGTGTGCGCGATAGCTGATAGCTTCGTTACGATATACACGTCCCGGACAGA TGAT GCGGATAGGAGGCTGTGAAGTTTCCATCACACGAGTCTGTACAGAAGAAGTATGTGTACG CAAT ACTACGTCCGGGTGAGCTTCGATAAAGAAAGTGTCCTGCATATCGCGTGCCGGATGATCT TCGG CAAAGTTCAGTGCCGAGAACACGTGCCAGTCATCTTCAATTTCCGGACCTTCGGCAATGC TGAA TCCCAGACGGGCAAAGATATCAATGATTTCGTTCTTTACAATGGTGAGCGGGTGGCGTGT ACCG AGTTCTACAGGATAAGCCGAACGCGTCAAATCCAGTCCGTCACAATCGTTGTCCTGACTT TCAA ACATTTCTTTCAGCGCGTTGATTTTGTCCTGCGCTTTTGTTTTCAGTTCATTCAGTCTCA TGCC GACTTCTTTTTTCTGTTCGGCAGCTACATTACGGAAATCTGCCATTAAGTCGTTAATGGC TCCC TTCTTACTTAGGTATTTGATGCGGAGAGCTTCGAGTTCTTCGGCATTGGAGGCGTGTAAG GCTT CCACCTCTTTCAGAAGTTGTTCAATCTTAGCTATCATTTTTTAATATTTTTAGCGGCCCC GTTA AACAAAATTATTTGTAGAGGCTGTTTCGTCCTCACGGACTCATCAGACCGGAAAGCACAT CCGG TGACAGCTCAGGCTACTTTGTTTCTTTCGACACTGCAAATATAAGAACATTATTTGAAAG TTCA AGTGAAACTTTAAATTTTAACAATAGATTAACCATTGCAAACAAAACAAAAAAAAGGTAG CCCA ATTGTAAAACGAAAGGCCCAGTCTTTCGACTGAGCCTTTCGTTTTATCCTAGGATCAGCT GTAC GTACTCGCAGTTCAACCTGTTGATAGTACGTACTAAGCTCTCATGTTTCACGTACTAAGC TCTC ATGTTTAACGTACTAAGCTCTCATGTTTAACGAACTAAACCCTCATGGCTAACGTACTAA GCTC TCATGGCTAACGTACTAAGCTCTCATGTTTCACGTACTAAGCTCTCATGTTTGAACAATA AAAT TAATATAAATCAGCAACTTAAATAGCCTCTAAGGTTTTAAGTTTTATAAGAAAAAAAAGA ATAT ATAAGGCTTTTAAAGCTTTTAAGGTTTAACGGTTGTGGACAACAAGCCAGGGATGTAACG CACT GAGAAGCCCTTAGAGCCTCTCAAAGCAATTTTGAGTGACACAGGAACACTTAACGGCTGA CATG GGGCGGCCGCGTAG [00252] SEQ ID NO: 96 (Ribosome binding site RBS1 and At_AAE3 open reading frame): GCATCTAAACTAAAATACAATAACCAAAAATCATTACAAATGAAAAAAAATAATAAAATG GATA GCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCCCGATCGCCGAGCTC TCTC CGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTAATCGAACGCGCCGC TTCA CGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTCTCACCTTCCCTAAC ACCG TCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCACGGCGGCGCCGTTGA ACGC AGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGATTCAAAGCTATTGTT AACC TCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGAAAATCTCTCACGTC ACCG CTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGATTCAGATTCCGTCG TTGA CTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTCCTCCACACTTCTGG CACT ACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTTCATCCGTCAAGAAC ATTA AAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCTCCCTCTGTTCCATG TTCA TGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCTGTAACTCTTCCAGC TGCT GGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATAACGCTACATGGTAT ACTG CTGTGCCGACCATTCATCAGATCATATTGGACCGCCACGCGAGCCACCCTGAAACGGAAT ATCC TAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTGATATTGTCCAGGCT TGAG GAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGGCAACACATTTGATG AGCT CAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGGGAAACCGGTAGGTC AAGA AATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAACAAAGGAGAGGTTTG TATA AGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCAACAAGGCAGGTTTC GAGT TTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGATACCGATGGGTATTTGCATCTGG TGGG TCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCAATTGAAGTGGATGC AGTA CTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTCCTGATGAGAAATAT GGGG AAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAACCGAAGAGGACATTA AAGC GTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTGTTCATCACTGATAA CCTC CCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAACATTTCCTTGAGAAG CCC [00253] SEQ ID NO: 97 (Ribosome binding site RBS2 and At_AAE3 open reading frame): GCATCTAAACTAAAATACAATAACCAAAAATCATGTTTAACAAATAAAAATAATAAAATG GATA GCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCCCGATCGCCGAGCTC TCTC CGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTAATCGAACGCGCCGC TTCA CGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTCTCACCTTCCCTAAC ACCG TCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCACGGCGGCGCCGTTGA ACGC AGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGATTCAAAGCTATTGTT AACC TCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGAAAATCTCTCACGTC ACCG CTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGATTCAGATTCCGTCG TTGA CTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTCCTCCACACTTCTGG CACT ACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTTCATCCGTCAAGAAC ATTA AAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCTCCCTCTGTTCCATG TTCA TGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCTGTAACTCTTCCAGC TGCT GGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATAACGCTACATGGTAT ACTG CTGTGCCGACCATTCATCAGATCATATTGGACCGCCACGCGAGCCACCCTGAAACGGAAT ATCC TAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTGATATTGTCCAGGCT TGAG GAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGGCAACACATTTGATG AGCT CAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGGGAAACCGGTAGGTC AAGA AATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAACAAAGGAGAGGTTTG TATA AGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCAACAAGGCAGGTTTC GAGT TTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGATACCGATGGGTATTTGCATCTGG TGGG TCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCAATTGAAGTGGATGC AGTA CTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTCCTGATGAGAAATAT GGGG AAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAACCGAAGAGGACATTA AAGC GTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTGTTCATCACTGATAA CCTC CCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAACATTTCCTTGAGAAG CCC [00254] SEQ ID NO: 98 (Ribosome binding site RBS3 and At_AAE3 open reading frame): GCATCTAAACTAAAATACAATAACCAAAAATCATCTATGCGTAAAAAAAATTATAAAATG GATA GCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCCCGATCGCCGAGCTC TCTC CGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTAATCGAACGCGCCGC TTCA CGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTCTCACCTTCCCTAAC ACCG TCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCACGGCGGCGCCGTTGA ACGC AGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGATTCAAAGCTATTGTT AACC TCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGAAAATCTCTCACGTC ACCG CTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGATTCAGATTCCGTCG TTGA CTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTCCTCCACACTTCTGG CACT ACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTTCATCCGTCAAGAAC ATTA AAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCTCCCTCTGTTCCATG TTCA TGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCTGTAACTCTTCCAGC TGCT GGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATAACGCTACATGGTAT ACTG CTGTGCCGACCATTCATCAGATCATATTGGACCGCCACGCGAGCCACCCTGAAACGGAAT ATCC TAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTGATATTGTCCAGGCT TGAG GAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGGCAACACATTTGATG AGCT CAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGGGAAACCGGTAGGTC AAGA AATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAACAAAGGAGAGGTTTG TATA AGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCAACAAGGCAGGTTTC GAGT TTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGATACCGATGGGTATTTGCATCTGG TGGG TCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCAATTGAAGTGGATGC AGTA CTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTCCTGATGAGAAATAT GGGG AAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAACCGAAGAGGACATTA AAGC GTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTGTTCATCACTGATAA CCTC CCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAACATTTCCTTGAGAAG CCC [00255] SEQ ID NO: 99 (Ribosome binding site RBS4 and At_AAE3 open reading frame): GCATCTAAACTAAAATACAATAACCAAAAATCATACTACATGTATAAAATTAAAAAAATG GATA GCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCCCGATCGCCGAGCTC TCTC CGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTAATCGAACGCGCCGC TTCA CGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTCTCACCTTCCCTAAC ACCG TCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCACGGCGGCGCCGTTGA ACGC AGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGATTCAAAGCTATTGTT AACC TCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGAAAATCTCTCACGTC ACCG CTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGATTCAGATTCCGTCG TTGA CTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTCCTCCACACTTCTGG CACT ACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTTCATCCGTCAAGAAC ATTA AAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCTCCCTCTGTTCCATG TTCA TGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCTGTAACTCTTCCAGC TGCT GGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATAACGCTACATGGTAT ACTG CTGTGCCGACCATTCATCAGATCATATTGGACCGCCACGCGAGCCACCCTGAAACGGAAT ATCC TAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTGATATTGTCCAGGCT TGAG GAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGGCAACACATTTGATG AGCT CAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGGGAAACCGGTAGGTC AAGA AATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAACAAAGGAGAGGTTTG TATA AGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCAACAAGGCAGGTTTC GAGT TTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGATACCGATGGGTATTTGCATCTGG TGGG TCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCAATTGAAGTGGATGC AGTA CTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTCCTGATGAGAAATAT GGGG AAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAACCGAAGAGGACATTA AAGC GTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTGTTCATCACTGATAA CCTC CCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAACATTTCCTTGAGAAG CCC [00256] SEQ ID NO: 100 (Ribosome binding site RBS5 and At_AAE3 open reading frame): GCATCTAAACTAAAATACAATAACCAAAAATCATTTTCACAATATAAAAATAACAAAATG GATA GCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCCCGATCGCCGAGCTC TCTC CGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTAATCGAACGCGCCGC TTCA CGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTCTCACCTTCCCTAAC ACCG TCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCACGGCGGCGCCGTTGA ACGC AGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGATTCAAAGCTATTGTT AACC TCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGAAAATCTCTCACGTC ACCG CTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGATTCAGATTCCGTCG TTGA CTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTCCTCCACACTTCTGG CACT ACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTTCATCCGTCAAGAAC ATTA AAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCTCCCTCTGTTCCATG TTCA TGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCTGTAACTCTTCCAGC TGCT GGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATAACGCTACATGGTAT ACTG CTGTGCCGACCATTCATCAGATCATATTGGACCGCCACGCGAGCCACCCTGAAACGGAAT ATCC TAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTGATATTGTCCAGGCT TGAG GAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGGCAACACATTTGATG AGCT CAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGGGAAACCGGTAGGTC AAGA AATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAACAAAGGAGAGGTTTG TATA AGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCAACAAGGCAGGTTTC GAGT TTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGATACCGATGGGTATTTGCATCTGG TGGG TCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCAATTGAAGTGGATGC AGTA CTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTCCTGATGAGAAATAT GGGG AAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAACCGAAGAGGACATTA AAGC GTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTGTTCATCACTGATAA CCTC CCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAACATTTCCTTGAGAAG CCC [00257] SEQ ID NO: 101 (Ribosome binding site RBS6 and At_AAE3 open reading frame): GCATCATCTACCTCAATTATTCACCATTCCATCTGTCTAGCCAAAAAATTTAAAAAAATG GATA GCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCCCGATCGCCGAGCTC TCTC CGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTAATCGAACGCGCCGC TTCA CGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTCTCACCTTCCCTAAC ACCG TCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCACGGCGGCGCCGTTGA ACGC AGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGATTCAAAGCTATTGTT AACC TCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGAAAATCTCTCACGTC ACCG CTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGATTCAGATTCCGTCG TTGA CTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTCCTCCACACTTCTGG CACT ACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTTCATCCGTCAAGAAC ATTA AAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCTCCCTCTGTTCCATG TTCA TGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCTGTAACTCTTCCAGC TGCT GGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATAACGCTACATGGTAT ACTG CTGTGCCGACCATTCATCAGATCATATTGGACCGCCACGCGAGCCACCCTGAAACGGAAT ATCC TAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTGATATTGTCCAGGCT TGAG GAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGGCAACACATTTGATG AGCT CAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGGGAAACCGGTAGGTC AAGA AATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAACAAAGGAGAGGTTTG TATA AGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCAACAAGGCAGGTTTC GAGT TTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGATACCGATGGGTATTTGCATCTGG TGGG TCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCAATTGAAGTGGATGC AGTA CTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTCCTGATGAGAAATAT GGGG AAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAACCGAAGAGGACATTA AAGC GTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTGTTCATCACTGATAA CCTC CCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAACATTTCCTTGAGAAG CCC [00258] SEQ ID NO: 102 (Ribosome binding site RBS7 and At_AAE3 open reading frame): GCATCATCTACCTAAATTACTCATCATCCCATTTTAGTCAGCTTAAAATATTATAAAATG GATA GCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCCCGATCGCCGAGCTC TCTC CGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTAATCGAACGCGCCGC TTCA CGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTCTCACCTTCCCTAAC ACCG TCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCACGGCGGCGCCGTTGA ACGC AGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGATTCAAAGCTATTGTT AACC TCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGAAAATCTCTCACGTC ACCG CTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGATTCAGATTCCGTCG TTGA CTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTCCTCCACACTTCTGG CACT ACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTTCATCCGTCAAGAAC ATTA AAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCTCCCTCTGTTCCATG TTCA TGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCTGTAACTCTTCCAGC TGCT GGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATAACGCTACATGGTAT ACTG CTGTGCCGACCATTCATCAGATCATATTGGACCGCCACGCGAGCCACCCTGAAACGGAAT ATCC TAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTGATATTGTCCAGGCT TGAG GAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGGCAACACATTTGATG AGCT CAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGGGAAACCGGTAGGTC AAGA AATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAACAAAGGAGAGGTTTG TATA AGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCAACAAGGCAGGTTTC GAGT TTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGATACCGATGGGTATTTGCATCTGG TGGG TCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCAATTGAAGTGGATGC AGTA CTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTCCTGATGAGAAATAT GGGG AAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAACCGAAGAGGACATTA AAGC GTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTGTTCATCACTGATAA CCTC CCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAACATTTCCTTGAGAAG CCC [00259] SEQ ID NO: 103 (Ribosome binding site RBS8 and At_AAE3 open reading frame): GCATCATCTACCTATATTATTTATCATTCCATATCATGCGTGAATAAAAATAATAAAATG GATA GCGATACTCTCTCAGGATTATTGGAAAACGTCGCCAAAAAATTCCCCGATCGCCGAGCTC TCTC CGTTTCTGGAAAATTCAATCTCACTCACGCGCGTCTTCACGATCTAATCGAACGCGCCGC TTCA CGCCTTGTCTCCGACGCTGGAATCAAACCCGGCGATGTCGTTGCTCTCACCTTCCCTAAC ACCG TCGAGTTTGTTATAATGTTTTTAGCGGTGATAAGAGCTAGAGCCACGGCGGCGCCGTTGA ACGC AGCGTACACGGCGGAGGAATTTGAGTTTTACCTCTCCGATTCAGATTCAAAGCTATTGTT AACC TCTAAAGAAGGAAACGCACCGGCTCAAGAAGCAGCTTCAAAGCTGAAAATCTCTCACGTC ACCG CTACGCTGCTTGACGCTGGCTCGGACCTTGTACTATCCGTTGCGGATTCAGATTCCGTCG TTGA CTCAGCGACGGAACTCGTTAATCACCCGGACGACGGTGCTCTCTTCCTCCACACTTCTGG CACT ACGAGCCGTCCAAAGGGTGTACCGCTTACGCAGCTCAATCTAGCTTCATCCGTCAAGAAC ATTA AAGCTGTGTACAAGCTTACTGAGTCTGATTCTACGGTGATTGTTCTCCCTCTGTTCCATG TTCA TGGATTGTTAGCTGGGTTGCTTAGCTCGCTTGGAGCTGGTGCTGCTGTAACTCTTCCAGC TGCT GGTAGATTCTCAGCAACAACATTTTGGCCAGATATGAAGAAGTATAACGCTACATGGTAT ACTG CTGTGCCGACCATTCATCAGATCATATTGGACCGCCACGCGAGCCACCCTGAAACGGAAT ATCC TAAACTCCGGTTCATCAGGAGTTGCAGTGCTTCTTTGGCTCCGGTGATATTGTCCAGGCT TGAG GAAGCGTTTGGAGCACCGGTGCTCGAGGCCTATGCAATGACAGAGGCAACACATTTGATG AGCT CAAACCCCTTACCAGAGGAAGGTCCACACAAGCCTGGGTCTGTTGGGAAACCGGTAGGTC AAGA AATGGCGATCCTTAATGAGAAAGGCGAGATCCAAGAGCCAAATAACAAAGGAGAGGTTTG TATA AGAGGTCCAAATGTGACCAAGGGTTACAAGAATAACCCAGAAGCCAACAAGGCAGGTTTC GAGT TTGGGTGGTTCCACACTGGTGATATCGGTTACTTTGATACCGATGGGTATTTGCATCTGG TGGG TCGGATCAAAGAGCTTATTAACCGTGGAGGTGAGAAGATATCTCCAATTGAAGTGGATGC AGTA CTCTTAACGCATCCTGACGTTTCTCAGGGTGTTGCATTCGGTGTTCCTGATGAGAAATAT GGGG AAGAGATTAACTGTGCGGTGATTCCAAGAGAAGGAACTACTGTAACCGAAGAGGACATTA AAGC GTTTTGTAAGAAGAATTTGGCAGCTTTCAAGGTGCCAAAGAGAGTGTTCATCACTGATAA CCTC CCCAAAACTGCCTCTGGTAAGATTCAGCGCCGTATCGTCGCACAACATTTCCTTGAGAAG CCC [00260] SEQ ID NO: 104 (Ribosome binding site RBS1 and Sc_YBR222C open reading frame):

GCATCATCTACCTATATTAATCATCAACCCAATTTTCATATGTATAAAATTAACAAA ATGACAA GTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTAGCGTATCCGATAATGTCGCCG TTAT ACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCTGTTTTCAGACAAGATACAGTG GCGA TATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCCTCGGTGCTACTATGGACGCTA AAAT TGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTTCAATTTTTATTTGAATGACCT GAAA TCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTACAGAGTTCTGAAATTCTAAAA TCTG CCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCGATGCGACCAGGTTTAGGGTAG AGTA TGATATATACTCTCCAGAGGACAACTACAAAAGGGTTATTTACCGGTCTTTGAACAACGC CAAA TTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCCCGTTCCAGTGACGTTGCCCTG ATTT TGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGCCTTTGTTACATTTGAACATTG TGAG AAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCCCTTGGACAGATCTTATGTCGT GATG CCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTTTCCACTTTTAGAACTCAGGGT TCTG TTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGGACCAATTTGTTAAGTACAACT GTAA TTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCTGAACATGCCCAAACCAAACCC TTTC CCACACATTAGATTCATCAGATCGTGTTCTTCTGCTTTGGCTCCAGCAACGTTCCATAAG CTGG AGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGATGACCGAAGCATCACATCAAA TGAC CTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTACTGTGGGCCAGCCACAAGGAGT CACC GTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCGGGCAAAGTCGGCGAAGTTTCC ATCA GAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAAAAGCTAACAAGGAGAACTTCA CCAA GAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTTCGACCCTGAGGGGTTTTTGGT CCTT ACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAAAAGATTTCACCCATTGAGCTC GACG GCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTGCATTTGGTGTTCCCGACGATA TGTA CGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGGAGAAAAAATGACCTACGAAGA ACTG GTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATTCCAACCAAGGTGTACTTTGTT GATA AGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAGTTATCGCAGAAACTTTTGCTA AGAG CAGCAGAAATAAGAGTAAGTTG [00261] SEQ ID NO: 105 (Ribosome binding site RBS2 and Sc_YBR222C open reading frame):

GCATCTTTTCCATAACAAAAATTAAACCTCCTCCATATGAAAAATAAAAATTATAAA ATGACAA GTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTAGCGTATCCGATAATGTCGCCG TTAT TGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCTATCCCACATGGTGGGTCACTT CCAG ACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCTGTTTTCAGACAAGATACAGTG GCGA TATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCCTCGGTGCTACTATGGACGCTA AAAT TGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTTCAATTTTTATTTGAATGACCT GAAA TCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTACAGAGTTCTGAAATTCTAAAA TCTG CCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCGATGCGACCAGGTTTAGGGTAG AGTA TGATATATACTCTCCAGAGGACAACTACAAAAGGGTTATTTACCGGTCTTTGAACAACGC CAAA TTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCCCGTTCCAGTGACGTTGCCCTG ATTT TGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGCCTTTGTTACATTTGAACATTG TGAG AAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCCCTTGGACAGATCTTATGTCGT GATG CCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTTTCCACTTTTAGAACTCAGGGT TCTG TTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGGACCAATTTGTTAAGTACAACT GTAA TTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCTGAACATGCCCAAACCAAACCC TTTC CCACACATTAGATTCATCAGATCGTGTTCTTCTGCTTTGGCTCCAGCAACGTTCCATAAG CTGG AGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGATGACCGAAGCATCACATCAAA TGAC GTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCGGGCAAAGTCGGCGAAGTTTCC ATCA GAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAAAAGCTAACAAGGAGAACTTCA CCAA GAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTTCGACCCTGAGGGGTTTTTGGT CCTT ACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAAAAGATTTCACCCATTGAGCTC GACG GCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTGCATTTGGTGTTCCCGACGATA TGTA CGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGGAGAAAAAATGACCTACGAAGA ACTG GTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATTCCAACCAAGGTGTACTTTGTT GATA AGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAGTTATCGCAGAAACTTTTGCTA AGAG CAGCAGAAATAAGAGTAAGTTG [00262] SEQ ID NO: 106 (Ribosome binding site RBS3 and Sc_YBR222C open reading frame):

GCATCAACTACCTCAATTAATAATCAAACCATCTGAACAATGAATAAATTTAAAAAA ATGACAA GTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTAGCGTATCCGATAATGTCGCCG TTAT TGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCTATCCCACATGGTGGGTCACTT CCAG ACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCTGTTTTCAGACAAGATACAGTG GCGA TATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCCTCGGTGCTACTATGGACGCTA AAAT TGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTTCAATTTTTATTTGAATGACCT GAAA TCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTACAGAGTTCTGAAATTCTAAAA TCTG CCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCGATGCGACCAGGTTTAGGGTAG AGTA TGATATATACTCTCCAGAGGACAACTACAAAAGGGTTATTTACCGGTCTTTGAACAACGC CAAA TTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCCCGTTCCAGTGACGTTGCCCTG ATTT TGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGCCTTTGTTACATTTGAACATTG TGAG AAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCCCTTGGACAGATCTTATGTCGT GATG CCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTTTCCACTTTTAGAACTCAGGGT TCTG TTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGGACCAATTTGTTAAGTACAACT GTAA TTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCTGAACATGCCCAAACCAAACCC TTTC CCACACATTAGATTCATCAGATCGTGTTCTTCTGCTTTGGCTCCAGCAACGTTCCATAAG CTGG AGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGATGACCGAAGCATCACATCAAA TGAC CTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTACTGTGGGCCAGCCACAAGGAGT CACC GTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCGGGCAAAGTCGGCGAAGTTTCC ATCA GAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAAAAGCTAACAAGGAGAACTTCA CCAA GAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTTCGACCCTGAGGGGTTTTTGGT CCTT ACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAAAAGATTTCACCCATTGAGCTC GACG GCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTGCATTTGGTGTTCCCGACGATA TGTA CGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGGAGAAAAAATGACCTACGAAGA ACTG GTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATTCCAACCAAGGTGTACTTTGTT GATA AGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAGTTATCGCAGAAACTTTTGCTA AGAG CAGCAGAAATAAGAGTAAGTTG [00263] SEQ ID NO: 107 (Ribosome binding site RBS4 and Sc_YBR222C open reading frame):

GCATCTTTTCCATAACAAAAATTAAACCTCCTCCATATGAGATATAAAATTAACAAA ATGACAA GTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTAGCGTATCCGATAATGTCGCCG TTAT TGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCTATCCCACATGGTGGGTCACTT CCAG ACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCTGTTTTCAGACAAGATACAGTG GCGA TATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCCTCGGTGCTACTATGGACGCTA AAAT TGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTTCAATTTTTATTTGAATGACCT GAAA TCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTACAGAGTTCTGAAATTCTAAAA TCTG CCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCGATGCGACCAGGTTTAGGGTAG AGTA TGATATATACTCTCCAGAGGACAACTACAAAAGGGTTATTTACCGGTCTTTGAACAACGC CAAA TTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCCCGTTCCAGTGACGTTGCCCTG ATTT TGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGCCTTTGTTACATTTGAACATTG TGAG AAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCCCTTGGACAGATCTTATGTCGT GATG CCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTTTCCACTTTTAGAACTCAGGGT TCTG TTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGGACCAATTTGTTAAGTACAACT GTAA TTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCTGAACATGCCCAAACCAAACCC TTTC CCACACATTAGATTCATCAGATCGTGTTCTTCTGCTTTGGCTCCAGCAACGTTCCATAAG CTGG AGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGATGACCGAAGCATCACATCAAA TGAC CTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTACTGTGGGCCAGCCACAAGGAGT CACC GTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCGGGCAAAGTCGGCGAAGTTTCC ATCA GAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAAAAGCTAACAAGGAGAACTTCA CCAA GAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTTCGACCCTGAGGGGTTTTTGGT CCTT ACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAAAAGATTTCACCCATTGAGCTC GACG GCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTGCATTTGGTGTTCCCGACGATA TGTA CGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGGAGAAAAAATGACCTACGAAGA ACTG GTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATTCCAACCAAGGTGTACTTTGTT GATA AGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAGTTATCGCAGAAACTTTTGCTA AGAG CAGCAGAAATAAGAGTAAGTTG [00264] SEQ ID NO: 108 (Ribosome binding site RBS5 and Sc_YBR222C open reading frame):

GCATCAACTACCTTAATTATTCATCAAACCATATAACATACTAAAAAAAATAACAAA ATGACAA GTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTAGCGTATCCGATAATGTCGCCG TTAT TGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCTATCCCACATGGTGGGTCACTT CCAG ACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCTGTTTTCAGACAAGATACAGTG GCGA TATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCCTCGGTGCTACTATGGACGCTA AAAT TGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTTCAATTTTTATTTGAATGACCT GAAA TCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTACAGAGTTCTGAAATTCTAAAA TCTG CCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCGATGCGACCAGGTTTAGGGTAG AGTA TGATATATACTCTCCAGAGGACAACTACAAAAGGGTTATTTACCGGTCTTTGAACAACGC CAAA TTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCCCGTTCCAGTGACGTTGCCCTG ATTT TGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGCCTTTGTTACATTTGAACATTG TGAG AAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCCCTTGGACAGATCTTATGTCGT GATG CCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTTTCCACTTTTAGAACTCAGGGT TCTG TTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGGACCAATTTGTTAAGTACAACT GTAA TTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCTGAACATGCCCAAACCAAACCC TTTC AGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGATGACCGAAGCATCACATCAAA TGAC CTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTACTGTGGGCCAGCCACAAGGAGT CACC GTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCGGGCAAAGTCGGCGAAGTTTCC ATCA GAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAAAAGCTAACAAGGAGAACTTCA CCAA GAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTTCGACCCTGAGGGGTTTTTGGT CCTT ACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAAAAGATTTCACCCATTGAGCTC GACG GCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTGCATTTGGTGTTCCCGACGATA TGTA CGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGGAGAAAAAATGACCTACGAAGA ACTG GTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATTCCAACCAAGGTGTACTTTGTT GATA AGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAGTTATCGCAGAAACTTTTGCTA AGAG CAGCAGAAATAAGAGTAAGTTG [00265] SEQ ID NO: 109 (Ribosome binding site RBS6 and Sc_YBR222C open reading frame):

GCATCATCTACCTATATTACTAATCATTCCAATTAATTACCTTATAAAATTAAGAAA ATGACAA GTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTAGCGTATCCGATAATGTCGCCG TTAT TGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCTATCCCACATGGTGGGTCACTT CCAG ACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCTGTTTTCAGACAAGATACAGTG GCGA TATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCCTCGGTGCTACTATGGACGCTA AAAT TGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTTCAATTTTTATTTGAATGACCT GAAA TCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTACAGAGTTCTGAAATTCTAAAA TCTG CCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCGATGCGACCAGGTTTAGGGTAG AGTA TGATATATACTCTCCAGAGGACAACTACAAAAGGGTTATTTACCGGTCTTTGAACAACGC CAAA TTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCCCGTTCCAGTGACGTTGCCCTG ATTT TGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGCCTTTGTTACATTTGAACATTG TGAG AAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCCCTTGGACAGATCTTATGTCGT GATG CCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTTTCCACTTTTAGAACTCAGGGT TCTG TTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGGACCAATTTGTTAAGTACAACT GTAA TTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCTGAACATGCCCAAACCAAACCC TTTC CCACACATTAGATTCATCAGATCGTGTTCTTCTGCTTTGGCTCCAGCAACGTTCCATAAG CTGG AGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGATGACCGAAGCATCACATCAAA TGAC CTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTACTGTGGGCCAGCCACAAGGAGT CACC GTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCGGGCAAAGTCGGCGAAGTTTCC ATCA GAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAAAAGCTAACAAGGAGAACTTCA CCAA GAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTTCGACCCTGAGGGGTTTTTGGT CCTT ACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAAAAGATTTCACCCATTGAGCTC GACG GCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTGCATTTGGTGTTCCCGACGATA TGTA CGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGGAGAAAAAATGACCTACGAAGA ACTG GTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATTCCAACCAAGGTGTACTTTGTT GATA AGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAGTTATCGCAGAAACTTTTGCTA AGAG CAGCAGAAATAAGAGTAAGTTG [00266] SEQ ID NO: 110 (Ribosome binding site RBS7 and Sc_YBR222C open reading frame):

GCATCTTTTCCATAACAAAAATTAAACCTCCTCCCCCCCACGTTTAAAATTAAAAAA ATGACAA GTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTAGCGTATCCGATAATGTCGCCG TTAT TGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCTATCCCACATGGTGGGTCACTT CCAG ACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCTGTTTTCAGACAAGATACAGTG GCGA TATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCCTCGGTGCTACTATGGACGCTA AAAT TGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTTCAATTTTTATTTGAATGACCT GAAA TCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTACAGAGTTCTGAAATTCTAAAA TCTG CCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCGATGCGACCAGGTTTAGGGTAG AGTA TGATATATACTCTCCAGAGGACAACTACAAAAGGGTTATTTACCGGTCTTTGAACAACGC CAAA TTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCCCGTTCCAGTGACGTTGCCCTG ATTT TGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGCCTTTGTTACATTTGAACATTG TGAG AAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCCCTTGGACAGATCTTATGTCGT GATG CCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTTTCCACTTTTAGAACTCAGGGT TCTG TTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGGACCAATTTGTTAAGTACAACT GTAA TTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCTGAACATGCCCAAACCAAACCC TTTC CCACACATTAGATTCATCAGATCGTGTTCTTCTGCTTTGGCTCCAGCAACGTTCCATAAG CTGG AGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGATGACCGAAGCATCACATCAAA TGAC CTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTACTGTGGGCCAGCCACAAGGAGT CACC GTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCGGGCAAAGTCGGCGAAGTTTCC ATCA GAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAAAAGCTAACAAGGAGAACTTCA CCAA GAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTTCGACCCTGAGGGGTTTTTGGT CCTT ACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAAAAGATTTCACCCATTGAGCTC GACG GCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTGCATTTGGTGTTCCCGACGATA TGTA CGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGGAGAAAAAATGACCTACGAAGA ACTG GTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATTCCAACCAAGGTGTACTTTGTT GATA AGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAGTTATCGCAGAAACTTTTGCTA AGAG CAGCAGAAATAAGAGTAAGTTG [00267] SEQ ID NO: 111 (Ribosome binding site RBS8 and Sc_YBR222C open reading frame):

GCATCAACTACCTTCATTACTTAACAATCCACCTGTTGTGAGTAAAAATATAAGAAA ATGACAA GTGCCGCTACTGTTACTGCTTCGTTCAACGATACTTTTAGCGTATCCGATAATGTCGCCG TTAT TGTTCCTGAAACGGACACTCAGGTGACCTACAGGGATCTATCCCACATGGTGGGTCACTT CCAG ACCATGTTCACAAATCCTAATTCTCCATTGTACGGAGCTGTTTTCAGACAAGATACAGTG GCGA TATCCATGCGTAATGGGCTGGAATTTATCGTCGCTTTCCTCGGTGCTACTATGGACGCTA AAAT TGGCGCGCCCTTGAATCCCAATTATAAGGAAAAGGAGTTCAATTTTTATTTGAATGACCT GAAA TCTAAGGCGATTTGCGTCCCAAAGGGTACCACAAAGTTACAGAGTTCTGAAATTCTAAAA TCTG CCTCCACGTTTGGATGTTTTATCGTAGAGCTGGCCTTCGATGCGACCAGGTTTAGGGTAG AGTA TGATATATACTCTCCAGAGGACAACTACAAAAGGGTTATTTACCGGTCTTTGAACAACGC CAAA TTTGTCAACACAAATCCCGTTAAATTCCCTGGGTTTGCCCGTTCCAGTGACGTTGCCCTG ATTT TGCATACCAGTGGTACCACCTCCACTCCAAAAACGGTGCCTTTGTTACATTTGAACATTG TGAG AAGCACGTTGAACATTGCTAACACTTACAAGCTAACGCCCTTGGACAGATCTTATGTCGT GATG CCTCTTTTCCACGTCCATGGGTTAATTGGTGTTTTACTTTCCACTTTTAGAACTCAGGGT TCTG TTGTGGTTCCCGATGGATTCCATCCAAAGTTATTCTGGGACCAATTTGTTAAGTACAACT GTAA TTGGTTCAGTTGCGTTCCCACAATAAGCATGATTATGCTGAACATGCCCAAACCAAACCC TTTC CCACACATTAGATTCATCAGATCGTGTTCTTCTGCTTTGGCTCCAGCAACGTTCCATAAG CTGG AGAAGGAATTCAATGCACCTGTCTTGGAGGCCTATGCGATGACCGAAGCATCACATCAAA TGAC CTCAAACAATCTGCCTCCAGGAAAGAGAAAGCCTGGTACTGTGGGCCAGCCACAAGGAGT CACC GTCGTCATTCTAGATGACAATGACAATGTCTTGCCCCCGGGCAAAGTCGGCGAAGTTTCC ATCA GAGGCGAAAACGTCACTTTGGGGTATGCTAATAATCCAAAAGCTAACAAGGAGAACTTCA CCAA GAGAGAGAACTATTTCAGAACCGGTGACCAAGGTTATTTCGACCCTGAGGGGTTTTTGGT CCTT ACAGGCAGAATCAAAGAGCTTATCAACAGGGGTGGTGAAAAGATTTCACCCATTGAGCTC GACG GCATTATGCTATCGCATCCAAAGATCGATGAAGCCGTTGCATTTGGTGTTCCCGACGATA TGTA CGGCCAAGTAGTTCAAGCCGCCATTGTTTTGAAGAAGGGAGAAAAAATGACCTACGAAGA ACTG GTGAACTTCTTAAAGAAGCACCTAGCCTCTTTCAAAATTCCAACCAAGGTGTACTTTGTT GATA AGCTACCAAAAACCGCTACAGGTAAAATCCAGAGAAGAGTTATCGCAGAAACTTTTGCTA AGAG CAGCAGAAATAAGAGTAAGTTG [00268] SEQ ID NO: 112 (Ribosome binding site RBS1 and Of_oxc open reading frame): GCATCCCCAAAAAATTAATTCATTTTCTCTTTTCCCTAACCCTTAAAATATAATAAAATG AGTA ACGACGACAATGTAGAGTTGACTGATGGCTTTCATGTTTTGATCGATGCCCTGAAAATGA ATGA CATCGATACCATGTATGGTGTTGTCGGCATTCCTATCACGAACCTGGCTCGTATGTGGCA AGAT GACGGTCAGCGTTTTTACAGCTTCCGTCACGAACAACACGCAGGTTATGCAGCTTCTATC GCCG GTTACATCGAAGGAAAACCTGGCGTTTGCTTGACCGTTTCCGCCCCTGGCTTCCTGAACG GCGT GACTTCCCTGGCTCATGCAACCACCAACTGCTTCCCAATGATCCTGTTGAGCGGTTCCAG TGAA CGTGAAATCGTCGATTTGCAACAGGGCGATTACGAAGAAATGGATCAGATGAATGTTGCA CGTC CACACTGCAAAGCTTCTTTCCGTATCAACAGCATCAAAGACATTCCAATCGGTATCGCTC GTGC AGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTGTTTACGTTGACTTGCCAGCAAAACT GTTC GGTCAGACCATTTCTGTAGAAGAAGCTAACAAACTGCTCTTCAAACCAATCGATCCAGCT CCGG CACAGATTCCTGCTGAAGATGCTATCGCTCGCGCTGCTGACCTGATCAAGAACGCCAAAC GTCC AGTTATCATGCTGGGTAAAGGCGCTGCATACGCACAATGCGACGACGAAATCCGCGCACT GGTT GAAGAAACCGGCATCCCATTCCTGCCAATGGGTATGGCTAAAGGCCTGCTGCCTGACAAC CATC CACAATCCGCTGCTGCAACCCGTGCTTTCGCACTGGCACAGTGTGACGTTTGCGTACTGA TCGG CGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAGGCAAAACCTGGGGCGACGAACTGAA GAAA TACGTTCAGATCGACATCCAGGCTAACGAAATGGACAGCAACCAGCCTATCGCTGCACCA GTTG TTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGCAAAGCACTGAAAGGCGCTCCAAAAG CTGA CGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTGACGGCAACAAAGCCAAACTGGCTGG CAAG ATGACTGCCGAAACCCCATCCGGAATGATGAACTACTCCAATTCCCTGGGCGTTGTTCGT GACT TCATGCTGGCAAATCCGGATATTTCCCTGGTTAACGAAGGCGCTAATGCACTCGACAACA CTCG TATGATTGTTGACATGCTGAAACCACGCAAACGTCTTGACTCCGGTACCTGGGGTGTTAT GGGT ATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGTTACCGGCAAACCGGTTATCGCTGTT GAAG GCGATAGCGCATTCGGTTTCTCCGGTATGGAACTGGAAACCATCTGCCGTTACAACCTGC CAGT TACCGTTATCATCATGAACAATGGTGGTATCTATAAAGGTAACGAAGCAGATCCACAACC AGGC GTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTACGACATGATGATGGAAGCATTTGGC GGTA AAGGTTATGTTGCCAATACTCCAGCAGAACTGAAAGCTGCTCTGGAAGAAGCTGTTGCTT CCGG CAAACCATGCCTGATCAACGCGATGATCGATCCAGACGCTGGTGTCGAATCTGGCCGTAT CAAG AGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAA [00269] SEQ ID NO: 113 (Ribosome binding site RBS2 and Of_oxc open reading frame): GCATCAACTACCTAAATTAATTATCACCCCAAATTAATAACATAAAAATATAATAAAATG AGTA ACGACGACAATGTAGAGTTGACTGATGGCTTTCATGTTTTGATCGATGCCCTGAAAATGA ATGA CATCGATACCATGTATGGTGTTGTCGGCATTCCTATCACGAACCTGGCTCGTATGTGGCA AGAT GACGGTCAGCGTTTTTACAGCTTCCGTCACGAACAACACGCAGGTTATGCAGCTTCTATC GCCG GTTACATCGAAGGAAAACCTGGCGTTTGCTTGACCGTTTCCGCCCCTGGCTTCCTGAACG GCGT GACTTCCCTGGCTCATGCAACCACCAACTGCTTCCCAATGATCCTGTTGAGCGGTTCCAG TGAA CGTGAAATCGTCGATTTGCAACAGGGCGATTACGAAGAAATGGATCAGATGAATGTTGCA CGTC CACACTGCAAAGCTTCTTTCCGTATCAACAGCATCAAAGACATTCCAATCGGTATCGCTC GTGC AGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTGTTTACGTTGACTTGCCAGCAAAACT GTTC GGTCAGACCATTTCTGTAGAAGAAGCTAACAAACTGCTCTTCAAACCAATCGATCCAGCT CCGG CACAGATTCCTGCTGAAGATGCTATCGCTCGCGCTGCTGACCTGATCAAGAACGCCAAAC GTCC AGTTATCATGCTGGGTAAAGGCGCTGCATACGCACAATGCGACGACGAAATCCGCGCACT GGTT GAAGAAACCGGCATCCCATTCCTGCCAATGGGTATGGCTAAAGGCCTGCTGCCTGACAAC CATC CACAATCCGCTGCTGCAACCCGTGCTTTCGCACTGGCACAGTGTGACGTTTGCGTACTGA TCGG CGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAGGCAAAACCTGGGGCGACGAACTGAA GAAA TACGTTCAGATCGACATCCAGGCTAACGAAATGGACAGCAACCAGCCTATCGCTGCACCA GTTG TTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGCAAAGCACTGAAAGGCGCTCCAAAAG CTGA CGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTGACGGCAACAAAGCCAAACTGGCTGG CAAG ATGACTGCCGAAACCCCATCCGGAATGATGAACTACTCCAATTCCCTGGGCGTTGTTCGT GACT TCATGCTGGCAAATCCGGATATTTCCCTGGTTAACGAAGGCGCTAATGCACTCGACAACA CTCG TATGATTGTTGACATGCTGAAACCACGCAAACGTCTTGACTCCGGTACCTGGGGTGTTAT GGGT ATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGTTACCGGCAAACCGGTTATCGCTGTT GAAG GCGATAGCGCATTCGGTTTCTCCGGTATGGAACTGGAAACCATCTGCCGTTACAACCTGC CAGT TACCGTTATCATCATGAACAATGGTGGTATCTATAAAGGTAACGAAGCAGATCCACAACC AGGC GTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTACGACATGATGATGGAAGCATTTGGC GGTA AAGGTTATGTTGCCAATACTCCAGCAGAACTGAAAGCTGCTCTGGAAGAAGCTGTTGCTT CCGG CAAACCATGCCTGATCAACGCGATGATCGATCCAGACGCTGGTGTCGAATCTGGCCGTAT CAAG AGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAA [00270] SEQ ID NO: 114 (Ribosome binding site RBS3 and Of_oxc open reading frame): GCATCAACTACCTAAATTAATTATCACCCCAAATTAATAACATAAAAATATAATAAAATG AGTA ACGACGACAATGTAGAGTTGACTGATGGCTTTCATGTTTTGATCGATGCCCTGAAAATGA ATGA CATCGATACCATGTATGGTGTTGTCGGCATTCCTATCACGAACCTGGCTCGTATGTGGCA AGAT GACGGTCAGCGTTTTTACAGCTTCCGTCACGAACAACACGCAGGTTATGCAGCTTCTATC GCCG GTTACATCGAAGGAAAACCTGGCGTTTGCTTGACCGTTTCCGCCCCTGGCTTCCTGAACG GCGT GACTTCCCTGGCTCATGCAACCACCAACTGCTTCCCAATGATCCTGTTGAGCGGTTCCAG TGAA CGTGAAATCGTCGATTTGCAACAGGGCGATTACGAAGAAATGGATCAGATGAATGTTGCA CGTC CACACTGCAAAGCTTCTTTCCGTATCAACAGCATCAAAGACATTCCAATCGGTATCGCTC GTGC AGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTGTTTACGTTGACTTGCCAGCAAAACT GTTC GGTCAGACCATTTCTGTAGAAGAAGCTAACAAACTGCTCTTCAAACCAATCGATCCAGCT CCGG CACAGATTCCTGCTGAAGATGCTATCGCTCGCGCTGCTGACCTGATCAAGAACGCCAAAC GTCC AGTTATCATGCTGGGTAAAGGCGCTGCATACGCACAATGCGACGACGAAATCCGCGCACT GGTT GAAGAAACCGGCATCCCATTCCTGCCAATGGGTATGGCTAAAGGCCTGCTGCCTGACAAC CATC CACAATCCGCTGCTGCAACCCGTGCTTTCGCACTGGCACAGTGTGACGTTTGCGTACTGA TCGG CGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAGGCAAAACCTGGGGCGACGAACTGAA GAAA TACGTTCAGATCGACATCCAGGCTAACGAAATGGACAGCAACCAGCCTATCGCTGCACCA GTTG TTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGCAAAGCACTGAAAGGCGCTCCAAAAG CTGA CGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTGACGGCAACAAAGCCAAACTGGCTGG CAAG ATGACTGCCGAAACCCCATCCGGAATGATGAACTACTCCAATTCCCTGGGCGTTGTTCGT GACT TCATGCTGGCAAATCCGGATATTTCCCTGGTTAACGAAGGCGCTAATGCACTCGACAACA CTCG TATGATTGTTGACATGCTGAAACCACGCAAACGTCTTGACTCCGGTACCTGGGGTGTTAT GGGT ATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGTTACCGGCAAACCGGTTATCGCTGTT GAAG GCGATAGCGCATTCGGTTTCTCCGGTATGGAACTGGAAACCATCTGCCGTTACAACCTGC CAGT TACCGTTATCATCATGAACAATGGTGGTATCTATAAAGGTAACGAAGCAGATCCACAACC AGGC GTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTACGACATGATGATGGAAGCATTTGGC GGTA AAGGTTATGTTGCCAATACTCCAGCAGAACTGAAAGCTGCTCTGGAAGAAGCTGTTGCTT CCGG CAAACCATGCCTGATCAACGCGATGATCGATCCAGACGCTGGTGTCGAATCTGGCCGTAT CAAG AGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAA [00271] SEQ ID NO: 115 (Ribosome binding site RBS4 and Of_oxc open reading frame): GCATCCCCAAAAAATTAATTCATTTTCTCTTTTCAACAATTTAAAAAAAATTAAAAAATG AGTA ACGACGACAATGTAGAGTTGACTGATGGCTTTCATGTTTTGATCGATGCCCTGAAAATGA ATGA CATCGATACCATGTATGGTGTTGTCGGCATTCCTATCACGAACCTGGCTCGTATGTGGCA AGAT GACGGTCAGCGTTTTTACAGCTTCCGTCACGAACAACACGCAGGTTATGCAGCTTCTATC GCCG GTTACATCGAAGGAAAACCTGGCGTTTGCTTGACCGTTTCCGCCCCTGGCTTCCTGAACG GCGT GACTTCCCTGGCTCATGCAACCACCAACTGCTTCCCAATGATCCTGTTGAGCGGTTCCAG TGAA CGTGAAATCGTCGATTTGCAACAGGGCGATTACGAAGAAATGGATCAGATGAATGTTGCA CGTC CACACTGCAAAGCTTCTTTCCGTATCAACAGCATCAAAGACATTCCAATCGGTATCGCTC GTGC AGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTGTTTACGTTGACTTGCCAGCAAAACT GTTC GGTCAGACCATTTCTGTAGAAGAAGCTAACAAACTGCTCTTCAAACCAATCGATCCAGCT CCGG CACAGATTCCTGCTGAAGATGCTATCGCTCGCGCTGCTGACCTGATCAAGAACGCCAAAC GTCC AGTTATCATGCTGGGTAAAGGCGCTGCATACGCACAATGCGACGACGAAATCCGCGCACT GGTT GAAGAAACCGGCATCCCATTCCTGCCAATGGGTATGGCTAAAGGCCTGCTGCCTGACAAC CATC CACAATCCGCTGCTGCAACCCGTGCTTTCGCACTGGCACAGTGTGACGTTTGCGTACTGA TCGG CGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAGGCAAAACCTGGGGCGACGAACTGAA GAAA TACGTTCAGATCGACATCCAGGCTAACGAAATGGACAGCAACCAGCCTATCGCTGCACCA GTTG TTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGCAAAGCACTGAAAGGCGCTCCAAAAG CTGA CGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTGACGGCAACAAAGCCAAACTGGCTGG CAAG ATGACTGCCGAAACCCCATCCGGAATGATGAACTACTCCAATTCCCTGGGCGTTGTTCGT GACT TCATGCTGGCAAATCCGGATATTTCCCTGGTTAACGAAGGCGCTAATGCACTCGACAACA CTCG TATGATTGTTGACATGCTGAAACCACGCAAACGTCTTGACTCCGGTACCTGGGGTGTTAT GGGT ATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGTTACCGGCAAACCGGTTATCGCTGTT GAAG GCGATAGCGCATTCGGTTTCTCCGGTATGGAACTGGAAACCATCTGCCGTTACAACCTGC CAGT TACCGTTATCATCATGAACAATGGTGGTATCTATAAAGGTAACGAAGCAGATCCACAACC AGGC GTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTACGACATGATGATGGAAGCATTTGGC GGTA AAGGTTATGTTGCCAATACTCCAGCAGAACTGAAAGCTGCTCTGGAAGAAGCTGTTGCTT CCGG CAAACCATGCCTGATCAACGCGATGATCGATCCAGACGCTGGTGTCGAATCTGGCCGTAT CAAG AGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAA [00272] SEQ ID NO: 116 (Ribosome binding site RBS5 and Of_oxc open reading frame): GCATCCCCAAAAAATTAATTCATTTTCTCTTTTCGATCCTATAAAAAATATAACAAAATG AGTA ACGACGACAATGTAGAGTTGACTGATGGCTTTCATGTTTTGATCGATGCCCTGAAAATGA ATGA CATCGATACCATGTATGGTGTTGTCGGCATTCCTATCACGAACCTGGCTCGTATGTGGCA AGAT GACGGTCAGCGTTTTTACAGCTTCCGTCACGAACAACACGCAGGTTATGCAGCTTCTATC GCCG GTTACATCGAAGGAAAACCTGGCGTTTGCTTGACCGTTTCCGCCCCTGGCTTCCTGAACG GCGT GACTTCCCTGGCTCATGCAACCACCAACTGCTTCCCAATGATCCTGTTGAGCGGTTCCAG TGAA CGTGAAATCGTCGATTTGCAACAGGGCGATTACGAAGAAATGGATCAGATGAATGTTGCA CGTC CACACTGCAAAGCTTCTTTCCGTATCAACAGCATCAAAGACATTCCAATCGGTATCGCTC GTGC AGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTGTTTACGTTGACTTGCCAGCAAAACT GTTC GGTCAGACCATTTCTGTAGAAGAAGCTAACAAACTGCTCTTCAAACCAATCGATCCAGCT CCGG CACAGATTCCTGCTGAAGATGCTATCGCTCGCGCTGCTGACCTGATCAAGAACGCCAAAC GTCC AGTTATCATGCTGGGTAAAGGCGCTGCATACGCACAATGCGACGACGAAATCCGCGCACT GGTT GAAGAAACCGGCATCCCATTCCTGCCAATGGGTATGGCTAAAGGCCTGCTGCCTGACAAC CATC CACAATCCGCTGCTGCAACCCGTGCTTTCGCACTGGCACAGTGTGACGTTTGCGTACTGA TCGG CGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAGGCAAAACCTGGGGCGACGAACTGAA GAAA TACGTTCAGATCGACATCCAGGCTAACGAAATGGACAGCAACCAGCCTATCGCTGCACCA GTTG TTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGCAAAGCACTGAAAGGCGCTCCAAAAG CTGA CGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTGACGGCAACAAAGCCAAACTGGCTGG CAAG ATGACTGCCGAAACCCCATCCGGAATGATGAACTACTCCAATTCCCTGGGCGTTGTTCGT GACT TCATGCTGGCAAATCCGGATATTTCCCTGGTTAACGAAGGCGCTAATGCACTCGACAACA CTCG TATGATTGTTGACATGCTGAAACCACGCAAACGTCTTGACTCCGGTACCTGGGGTGTTAT GGGT ATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGTTACCGGCAAACCGGTTATCGCTGTT GAAG GCGATAGCGCATTCGGTTTCTCCGGTATGGAACTGGAAACCATCTGCCGTTACAACCTGC CAGT TACCGTTATCATCATGAACAATGGTGGTATCTATAAAGGTAACGAAGCAGATCCACAACC AGGC GTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTACGACATGATGATGGAAGCATTTGGC GGTA AAGGTTATGTTGCCAATACTCCAGCAGAACTGAAAGCTGCTCTGGAAGAAGCTGTTGCTT CCGG CAAACCATGCCTGATCAACGCGATGATCGATCCAGACGCTGGTGTCGAATCTGGCCGTAT CAAG AGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAA [00273] SEQ ID NO: 117 (Ribosome binding site RBS6 and Of_oxc open reading frame): GCATCATCTACCTTTATTATTAATCAATCCATCTCAGTAAGTTTAAAATATAACAAAATG AGTA ACGACGACAATGTAGAGTTGACTGATGGCTTTCATGTTTTGATCGATGCCCTGAAAATGA ATGA CATCGATACCATGTATGGTGTTGTCGGCATTCCTATCACGAACCTGGCTCGTATGTGGCA AGAT GACGGTCAGCGTTTTTACAGCTTCCGTCACGAACAACACGCAGGTTATGCAGCTTCTATC GCCG GTTACATCGAAGGAAAACCTGGCGTTTGCTTGACCGTTTCCGCCCCTGGCTTCCTGAACG GCGT GACTTCCCTGGCTCATGCAACCACCAACTGCTTCCCAATGATCCTGTTGAGCGGTTCCAG TGAA CGTGAAATCGTCGATTTGCAACAGGGCGATTACGAAGAAATGGATCAGATGAATGTTGCA CGTC CACACTGCAAAGCTTCTTTCCGTATCAACAGCATCAAAGACATTCCAATCGGTATCGCTC GTGC AGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTGTTTACGTTGACTTGCCAGCAAAACT GTTC GGTCAGACCATTTCTGTAGAAGAAGCTAACAAACTGCTCTTCAAACCAATCGATCCAGCT CCGG CACAGATTCCTGCTGAAGATGCTATCGCTCGCGCTGCTGACCTGATCAAGAACGCCAAAC GTCC AGTTATCATGCTGGGTAAAGGCGCTGCATACGCACAATGCGACGACGAAATCCGCGCACT GGTT GAAGAAACCGGCATCCCATTCCTGCCAATGGGTATGGCTAAAGGCCTGCTGCCTGACAAC CATC CACAATCCGCTGCTGCAACCCGTGCTTTCGCACTGGCACAGTGTGACGTTTGCGTACTGA TCGG CGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAGGCAAAACCTGGGGCGACGAACTGAA GAAA TACGTTCAGATCGACATCCAGGCTAACGAAATGGACAGCAACCAGCCTATCGCTGCACCA GTTG TTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGCAAAGCACTGAAAGGCGCTCCAAAAG CTGA CGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTGACGGCAACAAAGCCAAACTGGCTGG CAAG ATGACTGCCGAAACCCCATCCGGAATGATGAACTACTCCAATTCCCTGGGCGTTGTTCGT GACT TCATGCTGGCAAATCCGGATATTTCCCTGGTTAACGAAGGCGCTAATGCACTCGACAACA CTCG TATGATTGTTGACATGCTGAAACCACGCAAACGTCTTGACTCCGGTACCTGGGGTGTTAT GGGT ATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGTTACCGGCAAACCGGTTATCGCTGTT GAAG GCGATAGCGCATTCGGTTTCTCCGGTATGGAACTGGAAACCATCTGCCGTTACAACCTGC CAGT TACCGTTATCATCATGAACAATGGTGGTATCTATAAAGGTAACGAAGCAGATCCACAACC AGGC GTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTACGACATGATGATGGAAGCATTTGGC GGTA AAGGTTATGTTGCCAATACTCCAGCAGAACTGAAAGCTGCTCTGGAAGAAGCTGTTGCTT CCGG CAAACCATGCCTGATCAACGCGATGATCGATCCAGACGCTGGTGTCGAATCTGGCCGTAT CAAG AGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAA [00274] SEQ ID NO: 118 (Ribosome binding site RBS7 and Of_oxc open reading frame): GCATCAACTACCTCTATTAATAATCAATCCACATCTTGATCGTAAAAAATTTAAAAAATG AGTA ACGACGACAATGTAGAGTTGACTGATGGCTTTCATGTTTTGATCGATGCCCTGAAAATGA ATGA CATCGATACCATGTATGGTGTTGTCGGCATTCCTATCACGAACCTGGCTCGTATGTGGCA AGAT GACGGTCAGCGTTTTTACAGCTTCCGTCACGAACAACACGCAGGTTATGCAGCTTCTATC GCCG GTTACATCGAAGGAAAACCTGGCGTTTGCTTGACCGTTTCCGCCCCTGGCTTCCTGAACG GCGT GACTTCCCTGGCTCATGCAACCACCAACTGCTTCCCAATGATCCTGTTGAGCGGTTCCAG TGAA CGTGAAATCGTCGATTTGCAACAGGGCGATTACGAAGAAATGGATCAGATGAATGTTGCA CGTC CACACTGCAAAGCTTCTTTCCGTATCAACAGCATCAAAGACATTCCAATCGGTATCGCTC GTGC AGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTGTTTACGTTGACTTGCCAGCAAAACT GTTC GGTCAGACCATTTCTGTAGAAGAAGCTAACAAACTGCTCTTCAAACCAATCGATCCAGCT CCGG CACAGATTCCTGCTGAAGATGCTATCGCTCGCGCTGCTGACCTGATCAAGAACGCCAAAC GTCC AGTTATCATGCTGGGTAAAGGCGCTGCATACGCACAATGCGACGACGAAATCCGCGCACT GGTT GAAGAAACCGGCATCCCATTCCTGCCAATGGGTATGGCTAAAGGCCTGCTGCCTGACAAC CATC CACAATCCGCTGCTGCAACCCGTGCTTTCGCACTGGCACAGTGTGACGTTTGCGTACTGA TCGG CGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAGGCAAAACCTGGGGCGACGAACTGAA GAAA TACGTTCAGATCGACATCCAGGCTAACGAAATGGACAGCAACCAGCCTATCGCTGCACCA GTTG TTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGCAAAGCACTGAAAGGCGCTCCAAAAG CTGA CGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTGACGGCAACAAAGCCAAACTGGCTGG CAAG ATGACTGCCGAAACCCCATCCGGAATGATGAACTACTCCAATTCCCTGGGCGTTGTTCGT GACT TCATGCTGGCAAATCCGGATATTTCCCTGGTTAACGAAGGCGCTAATGCACTCGACAACA CTCG TATGATTGTTGACATGCTGAAACCACGCAAACGTCTTGACTCCGGTACCTGGGGTGTTAT GGGT ATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGTTACCGGCAAACCGGTTATCGCTGTT GAAG GCGATAGCGCATTCGGTTTCTCCGGTATGGAACTGGAAACCATCTGCCGTTACAACCTGC CAGT TACCGTTATCATCATGAACAATGGTGGTATCTATAAAGGTAACGAAGCAGATCCACAACC AGGC GTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTACGACATGATGATGGAAGCATTTGGC GGTA AAGGTTATGTTGCCAATACTCCAGCAGAACTGAAAGCTGCTCTGGAAGAAGCTGTTGCTT CCGG CAAACCATGCCTGATCAACGCGATGATCGATCCAGACGCTGGTGTCGAATCTGGCCGTAT CAAG AGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAA [00275] SEQ ID NO: 119 (Ribosome binding site RBS8 and Of_oxc open reading frame): GCATCACCTACCTAAATTACTAAACAAACCACCTGCATTTGTTTTAAAAATTACAAAATG AGTA ACGACGACAATGTAGAGTTGACTGATGGCTTTCATGTTTTGATCGATGCCCTGAAAATGA ATGA CATCGATACCATGTATGGTGTTGTCGGCATTCCTATCACGAACCTGGCTCGTATGTGGCA AGAT GACGGTCAGCGTTTTTACAGCTTCCGTCACGAACAACACGCAGGTTATGCAGCTTCTATC GCCG GTTACATCGAAGGAAAACCTGGCGTTTGCTTGACCGTTTCCGCCCCTGGCTTCCTGAACG GCGT GACTTCCCTGGCTCATGCAACCACCAACTGCTTCCCAATGATCCTGTTGAGCGGTTCCAG TGAA CGTGAAATCGTCGATTTGCAACAGGGCGATTACGAAGAAATGGATCAGATGAATGTTGCA CGTC CACACTGCAAAGCTTCTTTCCGTATCAACAGCATCAAAGACATTCCAATCGGTATCGCTC GTGC AGTTCGCACCGCTGTATCCGGACGTCCAGGTGGTGTTTACGTTGACTTGCCAGCAAAACT GTTC GGTCAGACCATTTCTGTAGAAGAAGCTAACAAACTGCTCTTCAAACCAATCGATCCAGCT CCGG CACAGATTCCTGCTGAAGATGCTATCGCTCGCGCTGCTGACCTGATCAAGAACGCCAAAC GTCC AGTTATCATGCTGGGTAAAGGCGCTGCATACGCACAATGCGACGACGAAATCCGCGCACT GGTT GAAGAAACCGGCATCCCATTCCTGCCAATGGGTATGGCTAAAGGCCTGCTGCCTGACAAC CATC CACAATCCGCTGCTGCAACCCGTGCTTTCGCACTGGCACAGTGTGACGTTTGCGTACTGA TCGG CGCTCGTCTGAACTGGCTGATGCAGCACGGTAAAGGCAAAACCTGGGGCGACGAACTGAA GAAA TACGTTCAGATCGACATCCAGGCTAACGAAATGGACAGCAACCAGCCTATCGCTGCACCA GTTG TTGGTGACATCAAGTCCGCCGTTTCCCTGCTCCGCAAAGCACTGAAAGGCGCTCCAAAAG CTGA CGCTGAATGGACCGGCGCTCTGAAAGCCAAAGTTGACGGCAACAAAGCCAAACTGGCTGG CAAG ATGACTGCCGAAACCCCATCCGGAATGATGAACTACTCCAATTCCCTGGGCGTTGTTCGT GACT TCATGCTGGCAAATCCGGATATTTCCCTGGTTAACGAAGGCGCTAATGCACTCGACAACA CTCG TATGATTGTTGACATGCTGAAACCACGCAAACGTCTTGACTCCGGTACCTGGGGTGTTAT GGGT ATTGGTATGGGCTACTGCGTTGCTGCAGCTGCTGTTACCGGCAAACCGGTTATCGCTGTT GAAG GCGATAGCGCATTCGGTTTCTCCGGTATGGAACTGGAAACCATCTGCCGTTACAACCTGC CAGT TACCGTTATCATCATGAACAATGGTGGTATCTATAAAGGTAACGAAGCAGATCCACAACC AGGC GTTATCTCCTGTACCCGTCTGACCCGTGGTCGTTACGACATGATGATGGAAGCATTTGGC GGTA AAGGTTATGTTGCCAATACTCCAGCAGAACTGAAAGCTGCTCTGGAAGAAGCTGTTGCTT CCGG CAAACCATGCCTGATCAACGCGATGATCGATCCAGACGCTGGTGTCGAATCTGGCCGTAT CAAG AGCCTGAACGTTGTAAGTAAAGTTGGCAAGAAA [00276] SEQ ID NO: 120 (Ribosome binding site RBS1 and Sc_YEL020C open reading frame):

GCATCAACTACCTAAATTAATCATCAAACCAACTAGAATATGAAAAAAAATAAAAAA ATGACCA CGACCGCTACCCAACACTTCGCTCAACTTTTACAAAAATATGGCATCGACACAGTCTTTG GAAT TGTGGGCATCCCTATTGTCCAACTAGCGGATACGATGGTTGCCAACGGTATCAAATTCAT TCCA TGCAGGAACGAACAGGCTGCCTCATATGCAGCCTCTGCTTATGGTTATATTAGTGATAAG CCCG GCGTGTTACTTATTGTCGGGGGCCCCGGTTTAATCCACGCACTGGCTGGTATATACAACT CAAT GAGTAATAGGTGGCCTCTTCTAGTAATTGCAGGGAGTTCTTCTCAAAGTGATATACATAA AGGC GGGTTTCAAGAGTTGGATCAAGTTAGTCTTTTGTCCCCATTTTTGAAGTTTACCGGAAAG TTAA CCCCTGACAATATTGACATGATTACTCAGAAGGCTTTGAATTACTGTATACAAGGCACTG CAGG GGTTTCTTACATAGACGTCCCTGCAGATTTTATTGAGTATGAAAAACCCTTAGAAGGAAA CGAC CGTACAGGAAATGAATTACCGATGATATTAACTCCAAACATATGTGGCCCTGATCCGTCG AAGA TCAAAAAAGTCGTACAGCTTATTTTGCAACATAAAAATAAAAATATTCTGATTGTTATTG GAAA GGGTGCGGTAAAAAACTCACACGAAATCCGCAGACTAGTAAATACGTTCAATCTACCATT TTTA CCCACCCCAATGGCTAAGGGAATTGTCCCAGACTCTTCTCCACTGAACGTTTCATCTGCA AGAT CTCAAGCATTGAAAATAGCGGATATTGTTCTTGTTCTCGGGGCAAGATTAAACTGGATAT TGCA TTTTGGTACTTCACCCAAATGGAACTCAGAATCCATATTCATCCAGTTCGATTCCAATCC CGAA ACCTTGGGGGATAACAATGTCTCACCTGGTGCTGACCTTTCCATATGGGGAGATATAGGC TTGA GCGTAACCGCTTTAGTTGAGGAATTGACTCGCCAAGATTCCTGCTGGAAGTATAGTGGTG TTAA GCAAGAAATACGAGAGAAAATTCAACTGAATCAAACTCGTCTATTGAGGAAAGAGAAGAC TAGA GGGGCACAATTGAATTACAACCAGGTTTATGGAACATTGAGGCCTCTTATCGATGATTAC AGGA CAATACTTGTGACGGAGGGAGCAAATACTATGGATATTGCGCGTATTTCATTCCCTACAG ACGC TCCAAGGCGCCGTTTAGACGCAGGGACCAACGCGACTATGGGGATTGGGCTCGGATATGC TCTT GCATGCAAGGCATCTCATCCGGAACTCGATGTGGTGCTGATTCAGGGTGATTCCGCATTT GGAT TCTCTGCCATGGAAATTGAAACGGCAGTAAGGTGTCAGCTGGCATTGGTCATCGTTGTGA TGAA CAATAGCGGTATTTACCATGGAGAAAAGGATATAGAGGGTGATTTACCTCCAACGGCACT AAGC AAGAACTGCCGTTACGATCTCGTAGGCAAAGGACTGGGTGCCAATGATTTTTTTGTCAAC ACAA TAAGCGAACTGAGCAGATGCTTCCAACAAGCCGTGCAGCTTTCTCGGACTAAAAGAGAAA CAAG TGTCATCAACGTTATCATTGAGCCTGGCGAACAAAAGCAAATTGCCTTTGCCTGGCAGAA TAAA CCGCGTTTA [00277] SEQ ID NO: 121 (Ribosome binding site RBS2 and Sc_YEL020C open reading frame):

GCATCAACTACCTCAATTAATAAACAAACCAACTGTCCAATGTATAAAATTAAAAAA ATGACCA CGACCGCTACCCAACACTTCGCTCAACTTTTACAAAAATATGGCATCGACACAGTCTTTG GAAT TGTGGGCATCCCTATTGTCCAACTAGCGGATACGATGGTTGCCAACGGTATCAAATTCAT TCCA TGCAGGAACGAACAGGCTGCCTCATATGCAGCCTCTGCTTATGGTTATATTAGTGATAAG CCCG GCGTGTTACTTATTGTCGGGGGCCCCGGTTTAATCCACGCACTGGCTGGTATATACAACT CAAT GAGTAATAGGTGGCCTCTTCTAGTAATTGCAGGGAGTTCTTCTCAAAGTGATATACATAA AGGC GGGTTTCAAGAGTTGGATCAAGTTAGTCTTTTGTCCCCATTTTTGAAGTTTACCGGAAAG TTAA CCCCTGACAATATTGACATGATTACTCAGAAGGCTTTGAATTACTGTATACAAGGCACTG CAGG GGTTTCTTACATAGACGTCCCTGCAGATTTTATTGAGTATGAAAAACCCTTAGAAGGAAA CGAC CGTACAGGAAATGAATTACCGATGATATTAACTCCAAACATATGTGGCCCTGATCCGTCG AAGA TCAAAAAAGTCGTACAGCTTATTTTGCAACATAAAAATAAAAATATTCTGATTGTTATTG GAAA GGGTGCGGTAAAAAACTCACACGAAATCCGCAGACTAGTAAATACGTTCAATCTACCATT TTTA CCCACCCCAATGGCTAAGGGAATTGTCCCAGACTCTTCTCCACTGAACGTTTCATCTGCA AGAT CTCAAGCATTGAAAATAGCGGATATTGTTCTTGTTCTCGGGGCAAGATTAAACTGGATAT TGCA TTTTGGTACTTCACCCAAATGGAACTCAGAATCCATATTCATCCAGTTCGATTCCAATCC CGAA ACCTTGGGGGATAACAATGTCTCACCTGGTGCTGACCTTTCCATATGGGGAGATATAGGC TTGA GCGTAACCGCTTTAGTTGAGGAATTGACTCGCCAAGATTCCTGCTGGAAGTATAGTGGTG TTAA GCAAGAAATACGAGAGAAAATTCAACTGAATCAAACTCGTCTATTGAGGAAAGAGAAGAC TAGA GGGGCACAATTGAATTACAACCAGGTTTATGGAACATTGAGGCCTCTTATCGATGATTAC AGGA CAATACTTGTGACGGAGGGAGCAAATACTATGGATATTGCGCGTATTTCATTCCCTACAG ACGC TCCAAGGCGCCGTTTAGACGCAGGGACCAACGCGACTATGGGGATTGGGCTCGGATATGC TCTT GCATGCAAGGCATCTCATCCGGAACTCGATGTGGTGCTGATTCAGGGTGATTCCGCATTT GGAT TCTCTGCCATGGAAATTGAAACGGCAGTAAGGTGTCAGCTGGCATTGGTCATCGTTGTGA TGAA CAATAGCGGTATTTACCATGGAGAAAAGGATATAGAGGGTGATTTACCTCCAACGGCACT AAGC AAGAACTGCCGTTACGATCTCGTAGGCAAAGGACTGGGTGCCAATGATTTTTTTGTCAAC ACAA TAAGCGAACTGAGCAGATGCTTCCAACAAGCCGTGCAGCTTTCTCGGACTAAAAGAGAAA CAAG TGTCATCAACGTTATCATTGAGCCTGGCGAACAAAAGCAAATTGCCTTTGCCTGGCAGAA TAAA CCGCGTTTA [00278] SEQ ID NO: 122 (Ribosome binding site RBS3 and Sc_YEL020C open reading frame):

GCATCAACTACCTCAATTACTAAACAATCCACATTATTAATATAAAAATATAAAAAA ATGACCA CGACCGCTACCCAACACTTCGCTCAACTTTTACAAAAATATGGCATCGACACAGTCTTTG GAAT TGTGGGCATCCCTATTGTCCAACTAGCGGATACGATGGTTGCCAACGGTATCAAATTCAT TCCA TGCAGGAACGAACAGGCTGCCTCATATGCAGCCTCTGCTTATGGTTATATTAGTGATAAG CCCG GCGTGTTACTTATTGTCGGGGGCCCCGGTTTAATCCACGCACTGGCTGGTATATACAACT CAAT GAGTAATAGGTGGCCTCTTCTAGTAATTGCAGGGAGTTCTTCTCAAAGTGATATACATAA AGGC GGGTTTCAAGAGTTGGATCAAGTTAGTCTTTTGTCCCCATTTTTGAAGTTTACCGGAAAG TTAA CCCCTGACAATATTGACATGATTACTCAGAAGGCTTTGAATTACTGTATACAAGGCACTG CAGG GGTTTCTTACATAGACGTCCCTGCAGATTTTATTGAGTATGAAAAACCCTTAGAAGGAAA CGAC CGTACAGGAAATGAATTACCGATGATATTAACTCCAAACATATGTGGCCCTGATCCGTCG AAGA TCAAAAAAGTCGTACAGCTTATTTTGCAACATAAAAATAAAAATATTCTGATTGTTATTG GAAA GGGTGCGGTAAAAAACTCACACGAAATCCGCAGACTAGTAAATACGTTCAATCTACCATT TTTA CCCACCCCAATGGCTAAGGGAATTGTCCCAGACTCTTCTCCACTGAACGTTTCATCTGCA AGAT CTCAAGCATTGAAAATAGCGGATATTGTTCTTGTTCTCGGGGCAAGATTAAACTGGATAT TGCA TTTTGGTACTTCACCCAAATGGAACTCAGAATCCATATTCATCCAGTTCGATTCCAATCC CGAA ACCTTGGGGGATAACAATGTCTCACCTGGTGCTGACCTTTCCATATGGGGAGATATAGGC TTGA GCGTAACCGCTTTAGTTGAGGAATTGACTCGCCAAGATTCCTGCTGGAAGTATAGTGGTG TTAA GCAAGAAATACGAGAGAAAATTCAACTGAATCAAACTCGTCTATTGAGGAAAGAGAAGAC TAGA GGGGCACAATTGAATTACAACCAGGTTTATGGAACATTGAGGCCTCTTATCGATGATTAC AGGA CAATACTTGTGACGGAGGGAGCAAATACTATGGATATTGCGCGTATTTCATTCCCTACAG ACGC TCCAAGGCGCCGTTTAGACGCAGGGACCAACGCGACTATGGGGATTGGGCTCGGATATGC TCTT GCATGCAAGGCATCTCATCCGGAACTCGATGTGGTGCTGATTCAGGGTGATTCCGCATTT GGAT TCTCTGCCATGGAAATTGAAACGGCAGTAAGGTGTCAGCTGGCATTGGTCATCGTTGTGA TGAA CAATAGCGGTATTTACCATGGAGAAAAGGATATAGAGGGTGATTTACCTCCAACGGCACT AAGC AAGAACTGCCGTTACGATCTCGTAGGCAAAGGACTGGGTGCCAATGATTTTTTTGTCAAC ACAA TAAGCGAACTGAGCAGATGCTTCCAACAAGCCGTGCAGCTTTCTCGGACTAAAAGAGAAA CAAG TGTCATCAACGTTATCATTGAGCCTGGCGAACAAAAGCAAATTGCCTTTGCCTGGCAGAA TAAA CCGCGTTTA [00279] SEQ ID NO: 123 (Ribosome binding site RBS4 and Sc_YEL020C open reading frame):

GCATCAACACCTAAATTAATTAACACACCATATATTAAACCATAAAAAATAAGAAAA TGACCAC GACCGCTACCCAACACTTCGCTCAACTTTTACAAAAATATGGCATCGACACAGTCTTTGG AATT GTGGGCATCCCTATTGTCCAACTAGCGGATACGATGGTTGCCAACGGTATCAAATTCATT CCAT GCAGGAACGAACAGGCTGCCTCATATGCAGCCTCTGCTTATGGTTATATTAGTGATAAGC CCGG CGTGTTACTTATTGTCGGGGGCCCCGGTTTAATCCACGCACTGGCTGGTATATACAACTC AATG AGTAATAGGTGGCCTCTTCTAGTAATTGCAGGGAGTTCTTCTCAAAGTGATATACATAAA GGCG GGTTTCAAGAGTTGGATCAAGTTAGTCTTTTGTCCCCATTTTTGAAGTTTACCGGAAAGT TAAC CCCTGACAATATTGACATGATTACTCAGAAGGCTTTGAATTACTGTATACAAGGCACTGC AGGG GTTTCTTACATAGACGTCCCTGCAGATTTTATTGAGTATGAAAAACCCTTAGAAGGAAAC GACC GTACAGGAAATGAATTACCGATGATATTAACTCCAAACATATGTGGCCCTGATCCGTCGA AGAT CAAAAAAGTCGTACAGCTTATTTTGCAACATAAAAATAAAAATATTCTGATTGTTATTGG AAAG GGTGCGGTAAAAAACTCACACGAAATCCGCAGACTAGTAAATACGTTCAATCTACCATTT TTAC CCACCCCAATGGCTAAGGGAATTGTCCCAGACTCTTCTCCACTGAACGTTTCATCTGCAA GATC TCAAGCATTGAAAATAGCGGATATTGTTCTTGTTCTCGGGGCAAGATTAAACTGGATATT GCAT TTTGGTACTTCACCCAAATGGAACTCAGAATCCATATTCATCCAGTTCGATTCCAATCCC GAAA CCTTGGGGGATAACAATGTCTCACCTGGTGCTGACCTTTCCATATGGGGAGATATAGGCT TGAG CGTAACCGCTTTAGTTGAGGAATTGACTCGCCAAGATTCCTGCTGGAAGTATAGTGGTGT TAAG CAAGAAATACGAGAGAAAATTCAACTGAATCAAACTCGTCTATTGAGGAAAGAGAAGACT AGAG GGGCACAATTGAATTACAACCAGGTTTATGGAACATTGAGGCCTCTTATCGATGATTACA GGAC AATACTTGTGACGGAGGGAGCAAATACTATGGATATTGCGCGTATTTCATTCCCTACAGA CGCT CCAAGGCGCCGTTTAGACGCAGGGACCAACGCGACTATGGGGATTGGGCTCGGATATGCT CTTG CATGCAAGGCATCTCATCCGGAACTCGATGTGGTGCTGATTCAGGGTGATTCCGCATTTG GATT CTCTGCCATGGAAATTGAAACGGCAGTAAGGTGTCAGCTGGCATTGGTCATCGTTGTGAT GAAC AATAGCGGTATTTACCATGGAGAAAAGGATATAGAGGGTGATTTACCTCCAACGGCACTA AGCA AGAACTGCCGTTACGATCTCGTAGGCAAAGGACTGGGTGCCAATGATTTTTTTGTCAACA CAAT AAGCGAACTGAGCAGATGCTTCCAACAAGCCGTGCAGCTTTCTCGGACTAAAAGAGAAAC AAGT GTCATCAACGTTATCATTGAGCCTGGCGAACAAAAGCAAATTGCCTTTGCCTGGCAGAAT AAAC CGCGTTTA [00280] SEQ ID NO: 124 (Ribosome binding site RBS5 and Sc_YEL020C open reading frame):

GCATCTTCTACCCATATTCCCCCTAATCCCATCTGTTATATTATTAAATTTAATAAA ATGACCA CGACCGCTACCCAACACTTCGCTCAACTTTTACAAAAATATGGCATCGACACAGTCTTTG GAAT TGTGGGCATCCCTATTGTCCAACTAGCGGATACGATGGTTGCCAACGGTATCAAATTCAT TCCA TGCAGGAACGAACAGGCTGCCTCATATGCAGCCTCTGCTTATGGTTATATTAGTGATAAG CCCG GCGTGTTACTTATTGTCGGGGGCCCCGGTTTAATCCACGCACTGGCTGGTATATACAACT CAAT GAGTAATAGGTGGCCTCTTCTAGTAATTGCAGGGAGTTCTTCTCAAAGTGATATACATAA AGGC GGGTTTCAAGAGTTGGATCAAGTTAGTCTTTTGTCCCCATTTTTGAAGTTTACCGGAAAG TTAA CCCCTGACAATATTGACATGATTACTCAGAAGGCTTTGAATTACTGTATACAAGGCACTG CAGG GGTTTCTTACATAGACGTCCCTGCAGATTTTATTGAGTATGAAAAACCCTTAGAAGGAAA CGAC CGTACAGGAAATGAATTACCGATGATATTAACTCCAAACATATGTGGCCCTGATCCGTCG AAGA TCAAAAAAGTCGTACAGCTTATTTTGCAACATAAAAATAAAAATATTCTGATTGTTATTG GAAA GGGTGCGGTAAAAAACTCACACGAAATCCGCAGACTAGTAAATACGTTCAATCTACCATT TTTA CCCACCCCAATGGCTAAGGGAATTGTCCCAGACTCTTCTCCACTGAACGTTTCATCTGCA AGAT CTCAAGCATTGAAAATAGCGGATATTGTTCTTGTTCTCGGGGCAAGATTAAACTGGATAT TGCA TTTTGGTACTTCACCCAAATGGAACTCAGAATCCATATTCATCCAGTTCGATTCCAATCC CGAA ACCTTGGGGGATAACAATGTCTCACCTGGTGCTGACCTTTCCATATGGGGAGATATAGGC TTGA GCGTAACCGCTTTAGTTGAGGAATTGACTCGCCAAGATTCCTGCTGGAAGTATAGTGGTG TTAA GCAAGAAATACGAGAGAAAATTCAACTGAATCAAACTCGTCTATTGAGGAAAGAGAAGAC TAGA GGGGCACAATTGAATTACAACCAGGTTTATGGAACATTGAGGCCTCTTATCGATGATTAC AGGA CAATACTTGTGACGGAGGGAGCAAATACTATGGATATTGCGCGTATTTCATTCCCTACAG ACGC TCCAAGGCGCCGTTTAGACGCAGGGACCAACGCGACTATGGGGATTGGGCTCGGATATGC TCTT GCATGCAAGGCATCTCATCCGGAACTCGATGTGGTGCTGATTCAGGGTGATTCCGCATTT GGAT TCTCTGCCATGGAAATTGAAACGGCAGTAAGGTGTCAGCTGGCATTGGTCATCGTTGTGA TGAA CAATAGCGGTATTTACCATGGAGAAAAGGATATAGAGGGTGATTTACCTCCAACGGCACT AAGC AAGAACTGCCGTTACGATCTCGTAGGCAAAGGACTGGGTGCCAATGATTTTTTTGTCAAC ACAA TAAGCGAACTGAGCAGATGCTTCCAACAAGCCGTGCAGCTTTCTCGGACTAAAAGAGAAA CAAG TGTCATCAACGTTATCATTGAGCCTGGCGAACAAAAGCAAATTGCCTTTGCCTGGCAGAA TAAA CCGCGTTTA [00281] SEQ ID NO: 125 (Ribosome binding site RBS6 and Sc_YEL020C open reading frame):

GCATCATCTACCTACATTATTTAACAAACCACATTTAAAAGGAAAAAATATTAAAAA ATGACCA CGACCGCTACCCAACACTTCGCTCAACTTTTACAAAAATATGGCATCGACACAGTCTTTG GAAT TGTGGGCATCCCTATTGTCCAACTAGCGGATACGATGGTTGCCAACGGTATCAAATTCAT TCCA TGCAGGAACGAACAGGCTGCCTCATATGCAGCCTCTGCTTATGGTTATATTAGTGATAAG CCCG GCGTGTTACTTATTGTCGGGGGCCCCGGTTTAATCCACGCACTGGCTGGTATATACAACT CAAT GAGTAATAGGTGGCCTCTTCTAGTAATTGCAGGGAGTTCTTCTCAAAGTGATATACATAA AGGC GGGTTTCAAGAGTTGGATCAAGTTAGTCTTTTGTCCCCATTTTTGAAGTTTACCGGAAAG TTAA CCCCTGACAATATTGACATGATTACTCAGAAGGCTTTGAATTACTGTATACAAGGCACTG CAGG GGTTTCTTACATAGACGTCCCTGCAGATTTTATTGAGTATGAAAAACCCTTAGAAGGAAA CGAC CGTACAGGAAATGAATTACCGATGATATTAACTCCAAACATATGTGGCCCTGATCCGTCG AAGA TCAAAAAAGTCGTACAGCTTATTTTGCAACATAAAAATAAAAATATTCTGATTGTTATTG GAAA GGGTGCGGTAAAAAACTCACACGAAATCCGCAGACTAGTAAATACGTTCAATCTACCATT TTTA CCCACCCCAATGGCTAAGGGAATTGTCCCAGACTCTTCTCCACTGAACGTTTCATCTGCA AGAT CTCAAGCATTGAAAATAGCGGATATTGTTCTTGTTCTCGGGGCAAGATTAAACTGGATAT TGCA TTTTGGTACTTCACCCAAATGGAACTCAGAATCCATATTCATCCAGTTCGATTCCAATCC CGAA ACCTTGGGGGATAACAATGTCTCACCTGGTGCTGACCTTTCCATATGGGGAGATATAGGC TTGA GCGTAACCGCTTTAGTTGAGGAATTGACTCGCCAAGATTCCTGCTGGAAGTATAGTGGTG TTAA GCAAGAAATACGAGAGAAAATTCAACTGAATCAAACTCGTCTATTGAGGAAAGAGAAGAC TAGA GGGGCACAATTGAATTACAACCAGGTTTATGGAACATTGAGGCCTCTTATCGATGATTAC AGGA CAATACTTGTGACGGAGGGAGCAAATACTATGGATATTGCGCGTATTTCATTCCCTACAG ACGC TCCAAGGCGCCGTTTAGACGCAGGGACCAACGCGACTATGGGGATTGGGCTCGGATATGC TCTT GCATGCAAGGCATCTCATCCGGAACTCGATGTGGTGCTGATTCAGGGTGATTCCGCATTT GGAT TCTCTGCCATGGAAATTGAAACGGCAGTAAGGTGTCAGCTGGCATTGGTCATCGTTGTGA TGAA CAATAGCGGTATTTACCATGGAGAAAAGGATATAGAGGGTGATTTACCTCCAACGGCACT AAGC AAGAACTGCCGTTACGATCTCGTAGGCAAAGGACTGGGTGCCAATGATTTTTTTGTCAAC ACAA TAAGCGAACTGAGCAGATGCTTCCAACAAGCCGTGCAGCTTTCTCGGACTAAAAGAGAAA CAAG TGTCATCAACGTTATCATTGAGCCTGGCGAACAAAAGCAAATTGCCTTTGCCTGGCAGAA TAAA CCGCGTTTA [00282] SEQ ID NO: 126 (Ribosome binding site RBS7 and Sc_YEL020C open reading frame):

GCATCACCTACCTATATTATTTATCATTCCACATGCGTTATTATTAAATTTTAAAAA ATGACCA CGACCGCTACCCAACACTTCGCTCAACTTTTACAAAAATATGGCATCGACACAGTCTTTG GAAT TGTGGGCATCCCTATTGTCCAACTAGCGGATACGATGGTTGCCAACGGTATCAAATTCAT TCCA TGCAGGAACGAACAGGCTGCCTCATATGCAGCCTCTGCTTATGGTTATATTAGTGATAAG CCCG GCGTGTTACTTATTGTCGGGGGCCCCGGTTTAATCCACGCACTGGCTGGTATATACAACT CAAT GAGTAATAGGTGGCCTCTTCTAGTAATTGCAGGGAGTTCTTCTCAAAGTGATATACATAA AGGC GGGTTTCAAGAGTTGGATCAAGTTAGTCTTTTGTCCCCATTTTTGAAGTTTACCGGAAAG TTAA CCCCTGACAATATTGACATGATTACTCAGAAGGCTTTGAATTACTGTATACAAGGCACTG CAGG GGTTTCTTACATAGACGTCCCTGCAGATTTTATTGAGTATGAAAAACCCTTAGAAGGAAA CGAC CGTACAGGAAATGAATTACCGATGATATTAACTCCAAACATATGTGGCCCTGATCCGTCG AAGA TCAAAAAAGTCGTACAGCTTATTTTGCAACATAAAAATAAAAATATTCTGATTGTTATTG GAAA GGGTGCGGTAAAAAACTCACACGAAATCCGCAGACTAGTAAATACGTTCAATCTACCATT TTTA CCCACCCCAATGGCTAAGGGAATTGTCCCAGACTCTTCTCCACTGAACGTTTCATCTGCA AGAT CTCAAGCATTGAAAATAGCGGATATTGTTCTTGTTCTCGGGGCAAGATTAAACTGGATAT TGCA TTTTGGTACTTCACCCAAATGGAACTCAGAATCCATATTCATCCAGTTCGATTCCAATCC CGAA ACCTTGGGGGATAACAATGTCTCACCTGGTGCTGACCTTTCCATATGGGGAGATATAGGC TTGA GCGTAACCGCTTTAGTTGAGGAATTGACTCGCCAAGATTCCTGCTGGAAGTATAGTGGTG TTAA GCAAGAAATACGAGAGAAAATTCAACTGAATCAAACTCGTCTATTGAGGAAAGAGAAGAC TAGA GGGGCACAATTGAATTACAACCAGGTTTATGGAACATTGAGGCCTCTTATCGATGATTAC AGGA CAATACTTGTGACGGAGGGAGCAAATACTATGGATATTGCGCGTATTTCATTCCCTACAG ACGC TCCAAGGCGCCGTTTAGACGCAGGGACCAACGCGACTATGGGGATTGGGCTCGGATATGC TCTT GCATGCAAGGCATCTCATCCGGAACTCGATGTGGTGCTGATTCAGGGTGATTCCGCATTT GGAT TCTCTGCCATGGAAATTGAAACGGCAGTAAGGTGTCAGCTGGCATTGGTCATCGTTGTGA TGAA CAATAGCGGTATTTACCATGGAGAAAAGGATATAGAGGGTGATTTACCTCCAACGGCACT AAGC AAGAACTGCCGTTACGATCTCGTAGGCAAAGGACTGGGTGCCAATGATTTTTTTGTCAAC ACAA TAAGCGAACTGAGCAGATGCTTCCAACAAGCCGTGCAGCTTTCTCGGACTAAAAGAGAAA CAAG TGTCATCAACGTTATCATTGAGCCTGGCGAACAAAAGCAAATTGCCTTTGCCTGGCAGAA TAAA CCGCGTTTA [00283] SEQ ID NO: 127 (Ribosome binding site RBS8 and Sc_YEL020C open reading frame):

GCATCTAAACAACATATTCCCCCTAAACCAAAATATTTAGGGTATAAAAATTAAAAA ATGACCA CGACCGCTACCCAACACTTCGCTCAACTTTTACAAAAATATGGCATCGACACAGTCTTTG GAAT TGTGGGCATCCCTATTGTCCAACTAGCGGATACGATGGTTGCCAACGGTATCAAATTCAT TCCA TGCAGGAACGAACAGGCTGCCTCATATGCAGCCTCTGCTTATGGTTATATTAGTGATAAG CCCG GCGTGTTACTTATTGTCGGGGGCCCCGGTTTAATCCACGCACTGGCTGGTATATACAACT CAAT GAGTAATAGGTGGCCTCTTCTAGTAATTGCAGGGAGTTCTTCTCAAAGTGATATACATAA AGGC GGGTTTCAAGAGTTGGATCAAGTTAGTCTTTTGTCCCCATTTTTGAAGTTTACCGGAAAG TTAA CCCCTGACAATATTGACATGATTACTCAGAAGGCTTTGAATTACTGTATACAAGGCACTG CAGG GGTTTCTTACATAGACGTCCCTGCAGATTTTATTGAGTATGAAAAACCCTTAGAAGGAAA CGAC CGTACAGGAAATGAATTACCGATGATATTAACTCCAAACATATGTGGCCCTGATCCGTCG AAGA TCAAAAAAGTCGTACAGCTTATTTTGCAACATAAAAATAAAAATATTCTGATTGTTATTG GAAA GGGTGCGGTAAAAAACTCACACGAAATCCGCAGACTAGTAAATACGTTCAATCTACCATT TTTA CCCACCCCAATGGCTAAGGGAATTGTCCCAGACTCTTCTCCACTGAACGTTTCATCTGCA AGAT CTCAAGCATTGAAAATAGCGGATATTGTTCTTGTTCTCGGGGCAAGATTAAACTGGATAT TGCA TTTTGGTACTTCACCCAAATGGAACTCAGAATCCATATTCATCCAGTTCGATTCCAATCC CGAA ACCTTGGGGGATAACAATGTCTCACCTGGTGCTGACCTTTCCATATGGGGAGATATAGGC TTGA GCGTAACCGCTTTAGTTGAGGAATTGACTCGCCAAGATTCCTGCTGGAAGTATAGTGGTG TTAA GCAAGAAATACGAGAGAAAATTCAACTGAATCAAACTCGTCTATTGAGGAAAGAGAAGAC TAGA GGGGCACAATTGAATTACAACCAGGTTTATGGAACATTGAGGCCTCTTATCGATGATTAC AGGA CAATACTTGTGACGGAGGGAGCAAATACTATGGATATTGCGCGTATTTCATTCCCTACAG ACGC TCCAAGGCGCCGTTTAGACGCAGGGACCAACGCGACTATGGGGATTGGGCTCGGATATGC TCTT GCATGCAAGGCATCTCATCCGGAACTCGATGTGGTGCTGATTCAGGGTGATTCCGCATTT GGAT TCTCTGCCATGGAAATTGAAACGGCAGTAAGGTGTCAGCTGGCATTGGTCATCGTTGTGA TGAA CAATAGCGGTATTTACCATGGAGAAAAGGATATAGAGGGTGATTTACCTCCAACGGCACT AAGC AAGAACTGCCGTTACGATCTCGTAGGCAAAGGACTGGGTGCCAATGATTTTTTTGTCAAC ACAA TAAGCGAACTGAGCAGATGCTTCCAACAAGCCGTGCAGCTTTCTCGGACTAAAAGAGAAA CAAG TGTCATCAACGTTATCATTGAGCCTGGCGAACAAAAGCAAATTGCCTTTGCCTGGCAGAA TAAA CCGCGTTTA [00284] SEQ ID NO: 128 (Ribosome binding site RBS1 and Ec_yfdE open reading frame): GCATCATCTACCTTTATTAATCAACAATCCAAATTATTAATAAAAAAAATTTAAAAAATG ACAA ATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTATCGATATGACACATGTCCTTA ATGG ACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAGGGTAATTAAAGTTGAGCCGCC GGGT CATGGTGATGATACCCGCACATTTGGTCCCTATGTGGATGGACAGTCACTCTATTACAGT TTTA TTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGAATGATCACGATAAAAGTATAT TTAT AAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTTTCGCCCAGGTACAATGGAAAA ACTG GGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGCCTCATATATGCTTCATCGTCA GGTT TCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACGATACCATCATTCAGGCAATGA GCGG GATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGTGCGCGTTGGTACATCTCTTGC GGAT CTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGTGCACTTTATGGCCGCGAAAAG AGCC AGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCACGCTGAGTTTTCTGGAGCATG GTCT GATGGCATATATCGCAACTGGGAAGTCACCACAACGTCTGGGAAATCGCCATCCCTACAT GGCA CCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACGATTTGTTGTGGTAATGACAAG CTTT TTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGGTTAATGATCCCCGATTTAGCA GCAA TATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATATATTGAGCGGACGTTAAAAAC GCAG GCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGTGTACCCGTCGCGCCGTTATTA AGTG TGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAAATATGTTGATTGAAGCCGGGG GAAT AATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGCGGACCCGCATGTTATGCCGGG AGCG GCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAGTTCTCATCA [00285] SEQ ID NO: 129 (Ribosome binding site RBS2 and Ec_yfdE open reading frame): GCATCAACTACCTAAATTACTTATCAAACCACTTAGTAGTAAAAAAAATATAACAAAATG ACAA ATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTATCGATATGACACATGTCCTTA ATGG ACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAGGGTAATTAAAGTTGAGCCGCC GGGT CATGGTGATGATACCCGCACATTTGGTCCCTATGTGGATGGACAGTCACTCTATTACAGT TTTA TTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGAATGATCACGATAAAAGTATAT TTAT AAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTTTCGCCCAGGTACAATGGAAAA ACTG GGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGCCTCATATATGCTTCATCGTCA GGTT TCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACGATACCATCATTCAGGCAATGA GCGG GATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGTGCGCGTTGGTACATCTCTTGC GGAT CTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGTGCACTTTATGGCCGCGAAAAG AGCC AGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCACGCTGAGTTTTCTGGAGCATG GTCT GATGGCATATATCGCAACTGGGAAGTCACCACAACGTCTGGGAAATCGCCATCCCTACAT GGCA CCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACGATTTGTTGTGGTAATGACAAG CTTT TTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGGTTAATGATCCCCGATTTAGCA GCAA TATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATATATTGAGCGGACGTTAAAAAC GCAG GCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGTGTACCCGTCGCGCCGTTATTA AGTG TGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAAATATGTTGATTGAAGCCGGGG GAAT AATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGCGGACCCGCATGTTATGCCGGG AGCG GCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAGTTCTCATCA [00286] SEQ ID NO: 130 (Ribosome binding site RBS3 and Ec_yfdE open reading frame): GCATCACTATTACAAAAAAAACACCAATATTACATGGTCTCTTTTAAATATTATAAAATG ACAA ATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTATCGATATGACACATGTCCTTA ATGG ACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAGGGTAATTAAAGTTGAGCCGCC GGGT CATGGTGATGATACCCGCACATTTGGTCCCTATGTGGATGGACAGTCACTCTATTACAGT TTTA TTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGAATGATCACGATAAAAGTATAT TTAT AAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTTTCGCCCAGGTACAATGGAAAA ACTG GGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGCCTCATATATGCTTCATCGTCA GGTT TCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACGATACCATCATTCAGGCAATGA GCGG GATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGTGCGCGTTGGTACATCTCTTGC GGAT CTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGTGCACTTTATGGCCGCGAAAAG AGCC AGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCACGCTGAGTTTTCTGGAGCATG GTCT GATGGCATATATCGCAACTGGGAAGTCACCACAACGTCTGGGAAATCGCCATCCCTACAT GGCA CCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACGATTTGTTGTGGTAATGACAAG CTTT TTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGGTTAATGATCCCCGATTTAGCA GCAA TATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATATATTGAGCGGACGTTAAAAAC GCAG GCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGTGTACCCGTCGCGCCGTTATTA AGTG TGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAAATATGTTGATTGAAGCCGGGG GAAT AATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGCGGACCCGCATGTTATGCCGGG AGCG GCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAGTTCTCATCA

[00287] SEQ ID NO: 131 (Ribosome binding site RBS4 and Ec_yfdE open reading frame): GCATCATCTACCTATATTACTAAACAAACCAATTATAATAATTTTAAAAATAAAAAAATG ACAA ATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTATCGATATGACACATGTCCTTA ATGG ACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAGGGTAATTAAAGTTGAGCCGCC GGGT CATGGTGATGATACCCGCACATTTGGTCCCTATGTGGATGGACAGTCACTCTATTACAGT TTTA TTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGAATGATCACGATAAAAGTATAT TTAT AAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTTTCGCCCAGGTACAATGGAAAA ACTG GGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGCCTCATATATGCTTCATCGTCA GGTT TCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACGATACCATCATTCAGGCAATGA GCGG GATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGTGCGCGTTGGTACATCTCTTGC GGAT CTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGTGCACTTTATGGCCGCGAAAAG AGCC AGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCACGCTGAGTTTTCTGGAGCATG GTCT GATGGCATATATCGCAACTGGGAAGTCACCACAACGTCTGGGAAATCGCCATCCCTACAT GGCA CCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACGATTTGTTGTGGTAATGACAAG CTTT TTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGGTTAATGATCCCCGATTTAGCA GCAA TATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATATATTGAGCGGACGTTAAAAAC GCAG GCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGTGTACCCGTCGCGCCGTTATTA AGTG TGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAAATATGTTGATTGAAGCCGGGG GAAT AATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGCGGACCCGCATGTTATGCCGGG AGCG GCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAGTTCTCATCA [00288] SEQ ID NO: 132 (Ribosome binding site RBS5 and Ec_yfdE open reading frame): GCATCACCTACCTCTATTACTAATCAAACCATTTAAATGTAGTAAAAATATAATAAAATG ACAA ATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTATCGATATGACACATGTCCTTA ATGG ACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAGGGTAATTAAAGTTGAGCCGCC GGGT CATGGTGATGATACCCGCACATTTGGTCCCTATGTGGATGGACAGTCACTCTATTACAGT TTTA TTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGAATGATCACGATAAAAGTATAT TTAT AAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTTTCGCCCAGGTACAATGGAAAA ACTG GGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGCCTCATATATGCTTCATCGTCA GGTT TCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACGATACCATCATTCAGGCAATGA GCGG GATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGTGCGCGTTGGTACATCTCTTGC GGAT CTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGTGCACTTTATGGCCGCGAAAAG AGCC AGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCACGCTGAGTTTTCTGGAGCATG GTCT GATGGCATATATCGCAACTGGGAAGTCACCACAACGTCTGGGAAATCGCCATCCCTACAT GGCA CCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACGATTTGTTGTGGTAATGACAAG CTTT TTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGGTTAATGATCCCCGATTTAGCA GCAA TATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATATATTGAGCGGACGTTAAAAAC GCAG GCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGTGTACCCGTCGCGCCGTTATTA AGTG TGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAAATATGTTGATTGAAGCCGGGG GAAT AATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGCGGACCCGCATGTTATGCCGGG AGCG GCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAGTTCTCATCA [00289] SEQ ID NO: 133 (Ribosome binding site RBS6 and Ec_yfdE open reading frame): GCATCAACTACCTAAATTAATAAACACACCAACTTCCATGAATAAAAATATAAAAAAATG ACAA ATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTATCGATATGACACATGTCCTTA ATGG ACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAGGGTAATTAAAGTTGAGCCGCC GGGT CATGGTGATGATACCCGCACATTTGGTCCCTATGTGGATGGACAGTCACTCTATTACAGT TTTA TTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGAATGATCACGATAAAAGTATAT TTAT AAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTTTCGCCCAGGTACAATGGAAAA ACTG GGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGCCTCATATATGCTTCATCGTCA GGTT TCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACGATACCATCATTCAGGCAATGA GCGG GATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGTGCGCGTTGGTACATCTCTTGC GGAT CTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGTGCACTTTATGGCCGCGAAAAG AGCC AGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCACGCTGAGTTTTCTGGAGCATG GTCT GATGGCATATATCGCAACTGGGAAGTCACCACAACGTCTGGGAAATCGCCATCCCTACAT GGCA CCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACGATTTGTTGTGGTAATGACAAG CTTT TTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGGTTAATGATCCCCGATTTAGCA GCAA TATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATATATTGAGCGGACGTTAAAAAC GCAG GCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGTGTACCCGTCGCGCCGTTATTA AGTG TGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAAATATGTTGATTGAAGCCGGGG GAAT AATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGCGGACCCGCATGTTATGCCGGG AGCG GCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAGTTCTCATCA [00290] SEQ ID NO: 134 (Ribosome binding site RBS7 and Ec_yfdE open reading frame): GCATCATCTACCTATATTATTTACCACCCCACCTAACTTTAGATTAAAATTTACAAAATG ACAA ATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTATCGATATGACACATGTCCTTA ATGG ACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAGGGTAATTAAAGTTGAGCCGCC GGGT CATGGTGATGATACCCGCACATTTGGTCCCTATGTGGATGGACAGTCACTCTATTACAGT TTTA TTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGAATGATCACGATAAAAGTATAT TTAT AAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTTTCGCCCAGGTACAATGGAAAA ACTG GGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGCCTCATATATGCTTCATCGTCA GGTT TCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACGATACCATCATTCAGGCAATGA GCGG GATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGTGCGCGTTGGTACATCTCTTGC GGAT CTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGTGCACTTTATGGCCGCGAAAAG AGCC AGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCACGCTGAGTTTTCTGGAGCATG GTCT GATGGCATATATCGCAACTGGGAAGTCACCACAACGTCTGGGAAATCGCCATCCCTACAT GGCA CCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACGATTTGTTGTGGTAATGACAAG CTTT TTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGGTTAATGATCCCCGATTTAGCA GCAA TATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATATATTGAGCGGACGTTAAAAAC GCAG GCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGTGTACCCGTCGCGCCGTTATTA AGTG TGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAAATATGTTGATTGAAGCCGGGG GAAT AATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGCGGACCCGCATGTTATGCCGGG AGCG GCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAGTTCTCATCA

[00291] SEQ ID NO: 135 (Ribosome binding site RBS8 and Ec_yfdE open reading frame): GCATCACCTACCTTCATTACTCACCATACCAACTAGCACAGTTATAAAAATAAGAAAATG ACAA ATAATGAAAGCAAAGGGCCGTTTGAAGGCTTATTAGTTATCGATATGACACATGTCCTTA ATGG ACCTTTCGGAACTCAACTTCTTTGTAATATGGGCGCAAGGGTAATTAAAGTTGAGCCGCC GGGT CATGGTGATGATACCCGCACATTTGGTCCCTATGTGGATGGACAGTCACTCTATTACAGT TTTA TTAATCATGGCAAAGAGAGTGTGGTTCTTGATTTAAAGAATGATCACGATAAAAGTATAT TTAT AAATATGCTCAAACAAGCTGATGTATTAGCTGAGAATTTTCGCCCAGGTACAATGGAAAA ACTG GGGTTTTCATGGGAAACGCTTCAAGAAATCAACCCGCGCCTCATATATGCTTCATCGTCA GGTT TCGGACATACCGGTCCGCTAAAAGATGCTCCTGCCTACGATACCATCATTCAGGCAATGA GCGG GATAATGATGGAAACAGGATATCCTGATGCTCCGCCAGTGCGCGTTGGTACATCTCTTGC GGAT CTATGCGGCGGTGTCTATTTATTCAGCGGAATAGTGAGTGCACTTTATGGCCGCGAAAAG AGCC AGAGAGGGGCGCATGTCGATATAGCGATGTTTGATGCCACGCTGAGTTTTCTGGAGCATG GTCT GATGGCATATATCGCAACTGGGAAGTCACCACAACGTCTGGGAAATCGCCATCCCTACAT GGCA CCTTTTGATGTTTTCAATACTCAGGATAAGCCGATTACGATTTGTTGTGGTAATGACAAG CTTT TTTCTGCGTTATGCCAGGCACTGGAGCTTACGGAACTGGTTAATGATCCCCGATTTAGCA GCAA TATTTTACGCGTACAAAACCAGGCTATTCTTAAACAATATATTGAGCGGACGTTAAAAAC GCAG GCAGCTGAAGTTTGGTTAGCCAGAATACATGAAGTTGGTGTACCCGTCGCGCCGTTATTA AGTG TGGCTGAGGCCATTAAATTGCCACAAACTCAGGCGAGAAATATGTTGATTGAAGCCGGGG GAAT AATGATGCCGGGTAATCCGATAAAAATCAGCGGCTGCGCGGACCCGCATGTTATGCCGGG AGCG GCAACGCTCGACCAGCATGGGGAACAAATTCGCCAGGAGTTCTCATCA [00292] SEQ ID NO: 136 (Ribosome binding site RBS1 and Ec_frc open reading frame): GCATCATCTACCTAAATTAATAAACAACCCATTTATAAACCCTTTAAAATTAACAAAATG TCAA CTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGGCCCATCTTGTA CTCA AATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGCGTTGGTGACGT AACG CGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTTTACTTCACCATGCTTAACAGT AACA AACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAATGGAAAAGCTGA TCCG CGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCACATGGGCTTCAC CTGG GAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAGGGTTTGATGAG TGTT CGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGGTGGCGCGGCAT CCAC TACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGTGACAGCAACAC CGGA ATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAACGGGGCGTGGG CAAC GAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAAATTACGTGACC AGCA GCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAATGGTACATTTGG TGAT GCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGATCCTGAAATGT AAAG GCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTATTCAGGAGCAAAACTGGGAAA ACAC CTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCCGGCATACAGTACAGCCCATGC ACGA CAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCACTATTGATAAA CATG AAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTTAAGTATGAAAG AAAT TTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAACAACCGTTGCG TGGA AAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGGATATTAAAGCT GCGC CGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAGCGACGATGAAA TTGC TGCAATGAAGCAAAACCACGCCATC [00293] SEQ ID NO: 137 (Ribosome binding site RBS2 and Ec_frc open reading frame): GCATCTTAATCAATTTTAAACTCACCAAATCAAAATATGAAAAAAAAAAATAATAAAATG TCAA CTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGGCCCATCTTGTA CTCA AATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGCGTTGGTGACGT AACG CGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTTTACTTCACCATGCTTAACAGT AACA AACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAATGGAAAAGCTGA TCCG CGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCACATGGGCTTCAC CTGG GAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAGGGTTTGATGAG TGTT CGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGGTGGCGCGGCAT CCAC TACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGTGACAGCAACAC CGGA ATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAACGGGGCGTGGG CAAC GAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAAATTACGTGACC AGCA GCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAATGGTACATTTGG TGAT GCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGATCCTGAAATGT AAAG GCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTATTCAGGAGCAAAACTGGGAAA ACAC CTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCCGGCATACAGTACAGCCCATGC ACGA CAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCACTATTGATAAA CATG AAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTTAAGTATGAAAG AAAT TTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAACAACCGTTGCG TGGA AAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGGATATTAAAGCT GCGC CGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAGCGACGATGAAA TTGC TGCAATGAAGCAAAACCACGCCATC [00294] SEQ ID NO: 138 (Ribosome binding site RBS3 and Ec_frc open reading frame): GCATCATCTACCTTAATTAATAAACAAACCAATTTAACTAATTTAAAAAATATAAAATGT CAAC TCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGGCCCATCTTGTAC TCAA ATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGCGTTGGTGACGTA ACGC GTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTTTACTTCACCATGCTTAACAGTA ACAA ACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAATGGAAAAGCTGAT CCGC GAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCACATGGGCTTCACC TGGG AGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAGGGTTTGATGAGT GTTC GCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGGTGGCGCGGCATC CACT ACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGTGACAGCAACACC GGAA TGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAACGGGGCGTGGGC AACG AGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAAATTACGTGACCA GCAG CGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAATGGTACATTTGGT GATG CAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGATCCTGAAATGTA AAGG CTGGGAAACCGATCCTAACGCCTATATTTATTTCACTATTCAGGAGCAAAACTGGGAAAA CACC TGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCCGGCATACAGTACAGCCCATGCA CGAC AGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCACTATTGATAAAC ATGA AGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTTAAGTATGAAAGA AATT TCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAACAACCGTTGCGT GGAA AATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGGATATTAAAGCTG CGCC GCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAGCGACGATGAAAT TGCT GCAATGAAGCAAAACCACGCCATC [00295] SEQ ID NO: 139 (Ribosome binding site RBS4 and Ec_frc open reading frame): GCATCATCTACCTTCATTATTAATCATTCCAATTGTATCACTTAAAAATATAAAAAAATG TCAA CTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGGCCCATCTTGTA CTCA AATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGCGTTGGTGACGT AACG CGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTTTACTTCACCATGCTTAACAGT AACA AACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAATGGAAAAGCTGA TCCG CGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCACATGGGCTTCAC CTGG GAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAGGGTTTGATGAG TGTT CGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGGTGGCGCGGCAT CCAC TACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGTGACAGCAACAC CGGA ATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAACGGGGCGTGGG CAAC GAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAAATTACGTGACC AGCA GCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAATGGTACATTTGG TGAT GCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGATCCTGAAATGT AAAG GCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTATTCAGGAGCAAAACTGGGAAA ACAC CTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCCGGCATACAGTACAGCCCATGC ACGA CAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCACTATTGATAAA CATG AAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTTAAGTATGAAAG AAAT TTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAACAACCGTTGCG TGGA AAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGGATATTAAAGCT GCGC CGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAGCGACGATGAAA TTGC TGCAATGAAGCAAAACCACGCCATC [00296] SEQ ID NO: 140 (Ribosome binding site RBS5 and Ec_frc open reading frame): GCATCTTAATCAATTTTAAACTCACCAAATCAAATATCACGTAAAAAATATAAGAAAATG TCAA CTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGGCCCATCTTGTA CTCA AATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGCGTTGGTGACGT AACG CGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTTTACTTCACCATGCTTAACAGT AACA AACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAATGGAAAAGCTGA TCCG CGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCACATGGGCTTCAC CTGG GAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAGGGTTTGATGAG TGTT CGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGGTGGCGCGGCAT CCAC TACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGTGACAGCAACAC CGGA ATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAACGGGGCGTGGG CAAC GAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAAATTACGTGACC AGCA GCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAATGGTACATTTGG TGAT GCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGATCCTGAAATGT AAAG GCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTATTCAGGAGCAAAACTGGGAAA ACAC CTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCCGGCATACAGTACAGCCCATGC ACGA CAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCACTATTGATAAA CATG AAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTTAAGTATGAAAG AAAT TTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAACAACCGTTGCG TGGA AAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGGATATTAAAGCT GCGC CGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAGCGACGATGAAA TTGC TGCAATGAAGCAAAACCACGCCATC [00297] SEQ ID NO: 141 (Ribosome binding site RBS6 and Ec_frc open reading frame): GCATCAACTACCTCAATTATTTAACACACCAATTACTATACGTAAAAATATAAAAAAATG TCAA CTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGGCCCATCTTGTA CTCA AATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGCGTTGGTGACGT AACG CGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTTTACTTCACCATGCTTAACAGT AACA AACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAATGGAAAAGCTGA TCCG CGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCACATGGGCTTCAC CTGG GAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAGGGTTTGATGAG TGTT CGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGGTGGCGCGGCAT CCAC TACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGTGACAGCAACAC CGGA ATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAACGGGGCGTGGG CAAC GAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAAATTACGTGACC AGCA GCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAATGGTACATTTGG TGAT GCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGATCCTGAAATGT AAAG GCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTATTCAGGAGCAAAACTGGGAAA ACAC CTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCCGGCATACAGTACAGCCCATGC ACGA CAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCACTATTGATAAA CATG AAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTTAAGTATGAAAG AAAT TTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAACAACCGTTGCG TGGA AAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGGATATTAAAGCT GCGC CGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAGCGACGATGAAA TTGC TGCAATGAAGCAAAACCACGCCATC [00298] SEQ ID NO: 142 (Ribosome binding site RBS7 and Ec_frc open reading frame): GCATCTTAATCAATTTTAAACTCACCAAATCAAAAAAATGCGTATAAAAATTAAAAAATG TCAA CTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGGCCCATCTTGTA CTCA AATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGCGTTGGTGACGT AACG CGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTTTACTTCACCATGCTTAACAGT AACA AACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAATGGAAAAGCTGA TCCG CGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCACATGGGCTTCAC CTGG GAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAGGGTTTGATGAG TGTT CGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGGTGGCGCGGCAT CCAC TACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGTGACAGCAACAC CGGA ATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAACGGGGCGTGGG CAAC GAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAAATTACGTGACC AGCA GCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAATGGTACATTTGG TGAT GCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGATCCTGAAATGT AAAG GCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTATTCAGGAGCAAAACTGGGAAA ACAC CTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCCGGCATACAGTACAGCCCATGC ACGA CAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCACTATTGATAAA CATG AAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTTAAGTATGAAAG AAAT TTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAACAACCGTTGCG TGGA AAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGGATATTAAAGCT GCGC CGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAGCGACGATGAAA TTGC TGCAATGAAGCAAAACCACGCCATC [00299] SEQ ID NO: 143 (Ribosome binding site RBS8 and Ec_frc open reading frame): GCATCTTAATCAATTTTAAACTCACCAAATCAAAGGCCGACTTAAAAATATTAGAAAATG TCAA CTCCACTTCAAGGAATTAAAGTTCTCGATTTCACCGGTGTGCAATCTGGCCCATCTTGTA CTCA AATGCTGGCCTGGTTTGGCGCTGACGTTATTAAAATTGAACGTCCCGGCGTTGGTGACGT AACG CGTCACCAGCTGCGAGATATTCCTGATATCGATGCGCTTTACTTCACCATGCTTAACAGT AACA AACGTTCTATTGAGTTAAATACCAAAACAGCGGAAGGCAAAGAGGTAATGGAAAAGCTGA TCCG CGAAGCTGATATCTTAGTCGAGAACTTTCATCCAGGGGCCATTGATCACATGGGCTTCAC CTGG GAGCATATTCAAGAAATCAATCCACGTCTGATTTTTGGTTCGATCAAAGGGTTTGATGAG TGTT CGCCTTATGTGAATGTAAAAGCCTATGAAAACGTTGCTCAGGCAGCGGGTGGCGCGGCAT CCAC TACGGGTTTTTGGGATGGTCCGCCGCTGGTAAGCGCTGCAGCGTTGGGTGACAGCAACAC CGGA ATGCATTTGCTGATCGGTTTACTTGCTGCTTTGCTGCATCGCGAAAAAACGGGGCGTGGG CAAC GAGTCACCATGTCAATGCAGGATGCCGTATTGAACCTTTGCCGCGTGAAATTACGTGACC AGCA GCGTCTAGATAAATTGGGTTATCTGGAAGAATACCCGCAGTATCCGAATGGTACATTTGG TGAT GCAGTTCCCCGCGGTGGTAATGCAGGTGGTGGCGGTCAGCCTGGCTGGATCCTGAAATGT AAAG GCTGGGAAACCGATCCTAACGCCTATATTTATTTCACTATTCAGGAGCAAAACTGGGAAA ACAC CTGTAAAGCCATCGGCAAACCAGAATGGATTACCGATCCGGCATACAGTACAGCCCATGC ACGA CAGCCACATATTTTCGATATTTTTGCTGAAATCGAAAAATACACTGTCACTATTGATAAA CATG AAGCGGTGGCCTATTTGACTCAGTTTGATATTCCTTGTGCACCGGTTTTAAGTATGAAAG AAAT TTCACTTGATCCCTCTTTGCGCCAAAGTGGCAGTGTTGTTGAAGTGGAACAACCGTTGCG TGGA AAATATCTGACCGTTGGTTGTCCAATGAAATTCTCTGCCTTTACGCCGGATATTAAAGCT GCGC CGCTATTAGGTGAACATACCGCTGCTGTATTGCAGGAGCTGGGTTATAGCGACGATGAAA TTGC TGCAATGAAGCAAAACCACGCCATC [00300] SEQ ID NO: 144 (Ribosome binding site RBS1 and Of_oxlT open reading frame): GCATCACCTAAAAATTATAAATAAATTAATAAACCTTTTAACATAAAAATTAATAAAATG AATA ATCCACAAACAGGACAATCAACAGGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAG CAGT TTTGCTGATGTGTATGATCTCGGGTGTCCAATATTCCTGGACACTGTACGCTAACCCGGT TAAA GACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATT CAAG CTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGA TGTT CGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGC TCTG TATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAAC ACGG CTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACG GTCT GGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGC AGCA TTCATGTACACCGGTTTGATCATGGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGT TTCC CTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCG AAAT GCTGAGAACACCACAATTCTGGGTTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGG TTTG CTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTG ACGA TCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTT CCGA TAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGC ACTT TTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTC TTCA CATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCAACAGCGATATTTTCGGTACGGCAT ACTC TGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGG TCTG GGTGCTGCAATTGCAACCAACTTCGGATGGAATACCGCTTTCCTGATTACTGCGATTACT TCTT TCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAA TGGT CAAATTGTCTCCAGAAGAAAAAGCTGTACAT [00301] SEQ ID NO: 145 (Ribosome binding site RBS2 and Of_oxlT open reading frame): GCATCACCTAAAAATTATAAATAAATTAATAAACTTTTATTAAAAAAAAATTACAAAATG AATA ATCCACAAACAGGACAATCAACAGGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAG CAGT TTTGCTGATGTGTATGATCTCGGGTGTCCAATATTCCTGGACACTGTACGCTAACCCGGT TAAA GACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATT CAAG CTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGA TGTT CGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGC TCTG TATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAAC ACGG CTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACG GTCT GGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGC AGCA TTCATGTACACCGGTTTGATCATGGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGT TTCC CTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCG AAAT GCTGAGAACACCACAATTCTGGGTTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGG TTTG CTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTG ACGA TCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTT CCGA TAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGC ACTT TTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTC TTCA CATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCAACAGCGATATTTTCGGTACGGCAT ACTC TGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGG TCTG GGTGCTGCAATTGCAACCAACTTCGGATGGAATACCGCTTTCCTGATTACTGCGATTACT TCTT TCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAA TGGT CAAATTGTCTCCAGAAGAAAAAGCTGTACAT [00302] SEQ ID NO: 146 (Ribosome binding site RBS3 and Of_oxlT open reading frame): GCATCACCTAAAAATTATAAATAAATTAATAAACATAACATAAATAAAATTAATAAAATG AATA ATCCACAAACAGGACAATCAACAGGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAG CAGT TTTGCTGATGTGTATGATCTCGGGTGTCCAATATTCCTGGACACTGTACGCTAACCCGGT TAAA GACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATT CAAG CTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGA TGTT CGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGC TCTG TATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAAC ACGG CTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACG GTCT GGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGC AGCA TTCATGTACACCGGTTTGATCATGGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGT TTCC CTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCG AAAT GCTGAGAACACCACAATTCTGGGTTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGG TTTG CTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTG ACGA TCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTT CCGA TAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGC ACTT TTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTC TTCA CATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCAACAGCGATATTTTCGGTACGGCAT ACTC TGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGG TCTG GGTGCTGCAATTGCAACCAACTTCGGATGGAATACCGCTTTCCTGATTACTGCGATTACT TCTT TCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAA TGGT CAAATTGTCTCCAGAAGAAAAAGCTGTACAT [00303] SEQ ID NO: 147 (Ribosome binding site RBS4 and Of_oxlT open reading frame): GCATCACCTAAAAATTATAAATAAATTAATAAACCACAATACTAAAAATTTAATAAAATG AATA ATCCACAAACAGGACAATCAACAGGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAG CAGT TTTGCTGATGTGTATGATCTCGGGTGTCCAATATTCCTGGACACTGTACGCTAACCCGGT TAAA GACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATT CAAG CTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGA TGTT CGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGC TCTG TATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAAC ACGG CTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACG GTCT GGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGC AGCA TTCATGTACACCGGTTTGATCATGGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGT TTCC CTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCG AAAT GCTGAGAACACCACAATTCTGGGTTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGG TTTG CTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTG ACGA TCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTT CCGA TAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGC ACTT TTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTC TTCA CATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCAACAGCGATATTTTCGGTACGGCAT ACTC TGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGG TCTG GGTGCTGCAATTGCAACCAACTTCGGATGGAATACCGCTTTCCTGATTACTGCGATTACT TCTT TCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAA TGGT CAAATTGTCTCCAGAAGAAAAAGCTGTACAT [00304] SEQ ID NO: 148 (Ribosome binding site RBS5 and Of_oxlT open reading frame): GCATCAACTACCTACATTAATAACCAACCCAAATGCCTAATCAATAAATATTATAAAATG AATA ATCCACAAACAGGACAATCAACAGGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAG CAGT TTTGCTGATGTGTATGATCTCGGGTGTCCAATATTCCTGGACACTGTACGCTAACCCGGT TAAA GACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATT CAAG CTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGA TGTT CGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGC TCTG TATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAAC ACGG CTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACG GTCT GGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGC AGCA TTCATGTACACCGGTTTGATCATGGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGT TTCC CTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCG AAAT GCTGAGAACACCACAATTCTGGGTTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGG TTTG CTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTG ACGA TCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTT CCGA TAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGC ACTT TTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTC TTCA CATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCAACAGCGATATTTTCGGTACGGCAT ACTC TGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGG TCTG GGTGCTGCAATTGCAACCAACTTCGGATGGAATACCGCTTTCCTGATTACTGCGATTACT TCTT TCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAA TGGT CAAATTGTCTCCAGAAGAAAAAGCTGTACAT [00305] SEQ ID NO: 149 (Ribosome binding site RBS6 and Of_oxlT open reading frame): GCATCATCTACCTATATTATTCATCAAACCATTTGATCCAACATTAAATATTAAAAAATG AATA ATCCACAAACAGGACAATCAACAGGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAG CAGT TTTGCTGATGTGTATGATCTCGGGTGTCCAATATTCCTGGACACTGTACGCTAACCCGGT TAAA GACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATT CAAG CTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGA TGTT CGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGC TCTG TATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAAC ACGG CTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACG GTCT GGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGC AGCA TTCATGTACACCGGTTTGATCATGGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGT TTCC CTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCG AAAT GCTGAGAACACCACAATTCTGGGTTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGG TTTG CTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTG ACGA TCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTT CCGA TAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGC ACTT TTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTC TTCA CATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCAACAGCGATATTTTCGGTACGGCAT ACTC TGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGG TCTG GGTGCTGCAATTGCAACCAACTTCGGATGGAATACCGCTTTCCTGATTACTGCGATTACT TCTT TCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAA TGGT CAAATTGTCTCCAGAAGAAAAAGCTGTACAT [00306] SEQ ID NO: 150 (Ribosome binding site RBS7 and Of_oxlT open reading frame): GCATCACCTACCTCAATTATTAATCATACCAACTGGATTTGATTTAAAAATAAGAAAATG AATA ATCCACAAACAGGACAATCAACAGGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAG CAGT TTTGCTGATGTGTATGATCTCGGGTGTCCAATATTCCTGGACACTGTACGCTAACCCGGT TAAA GACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATT CAAG CTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGA TGTT CGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGC TCTG TATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAAC ACGG CTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACG GTCT GGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGC AGCA TTCATGTACACCGGTTTGATCATGGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGT TTCC CTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCG AAAT GCTGAGAACACCACAATTCTGGGTTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGG TTTG CTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTG ACGA TCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTT CCGA TAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGC ACTT TTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTC TTCA CATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCAACAGCGATATTTTCGGTACGGCAT ACTC TGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGG TCTG GGTGCTGCAATTGCAACCAACTTCGGATGGAATACCGCTTTCCTGATTACTGCGATTACT TCTT TCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAA TGGT CAAATTGTCTCCAGAAGAAAAAGCTGTACAT [00307] SEQ ID NO: 151 (Ribosome binding site RBS8 and Of_oxlT open reading frame): GCATCACCTACCTTTATTACTCATCATACCAAATGGTAGCGGATTAAATATTAGAAAATG AATA ATCCACAAACAGGACAATCAACAGGCCTCTTGGGCAATCGTTGGTTCTACTTGGTATTAG CAGT TTTGCTGATGTGTATGATCTCGGGTGTCCAATATTCCTGGACACTGTACGCTAACCCGGT TAAA GACAACCTTGGCGTTTCTTTGGCTGCGGTTCAGACGGCTTTCACACTCTCTCAGGTCATT CAAG CTGGTTCTCAGCCTGGTGGTGGTTACTTCGTTGATAAATTCGGTCCAAGAATTCCATTGA TGTT CGGTGGTGCGATGGTTCTCGCTGGCTGGACCTTCATGGGTATGGTTGACAGTGTTCCTGC TCTG TATGCTCTTTATACTCTGGCCGGTGCAGGTGTTGGTATCGTTTACGGTATCGCGATGAAC ACGG CTAACAGATGGTTCCCGGACAAACGCGGTCTGGCTTCCGGTTTCACCGCTGCCGGTTACG GTCT GGGTGTTCTGCCGTTCCTGCCACTGATCAGCTCCGTTCTGAAAGTTGAAGGTGTTGGCGC AGCA TTCATGTACACCGGTTTGATCATGGGTATCCTGATTATCCTGATCGCTTTCGTTATCCGT TTCC CTGGCCAGCAAGGCGCCAAAAAACAAATCGTTGTTACCGACAAGGATTTCAATTCTGGCG AAAT GCTGAGAACACCACAATTCTGGGTTCTGTGGACCGCATTCTTTTCCGTTAACTTTGGTGG TTTG CTGCTGGTTGCCAACAGCGTCCCTTACGGTCGCAGCCTCGGTCTTGCCGCAGGTGTGCTG ACGA TCGGTGTTTCGATCCAGAACCTGTTCAATGGTGGTTGCCGTCCTTTCTGGGGTTTCGTTT CCGA TAAAATCGGCCGTTACAAAACCATGTCCGTCGTTTTCGGTATCAATGCTGTTGTTCTCGC ACTT TTCCCGACGATTGCTGCCTTGGGCGATGTAGCCTTTATCGCCATGTTGGCAATCGCATTC TTCA CATGGGGTGGTAGCTACGCTCTGTTCCCATCGACCAACAGCGATATTTTCGGTACGGCAT ACTC TGCCAGAAACTATGGTTTCTTCTGGGCTGCAAAAGCAACTGCCTCGATCTTCGGTGGTGG TCTG GGTGCTGCAATTGCAACCAACTTCGGATGGAATACCGCTTTCCTGATTACTGCGATTACT TCTT TCATCGCATTTGCTCTGGCTACCTTCGTTATTCCAAGAATGGGCCGTCCAGTCAAGAAAA TGGT CAAATTGTCTCCAGAAGAAAAAGCTGTACAT [00308] SEQ ID NO: 152 (Ribosome binding site 'RBS1 and Sc_YEL020C (codon optimized) open reading frame):

GCATCATCTACCTTAATTAATCAACAAACCAATTACCAACCTAAAAAATATAAGAAA ATGACTA CCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCG GCAT AGTAGGTATTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTAT ACCG TGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAA CCTG GTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATA GTAT GTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAA GGGA GGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAA CTGA CGCCGGATAACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCG CCGG AGTGAGCTATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAA TGAT AGAACTGGTAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGT AAAA TTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAG GTAA AGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTT CCTT CCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCC CGGA GCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCC TTCA CTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCC GGAA ACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGA CTAT CGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAG TCAA ACAGGAGATCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAAC GCGT GGAGCTCAGCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTAT CGCA CGATCTTGGTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTG ATGC ACCTCGCAGAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGC ATTA GCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTC GGTT TTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAA TGAA TAACTCTGGGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTT GTCA AAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAAT ACCA TCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAA CCTC CGTCATTAATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAA CAAG CCTAGACTG [00309] SEQ ID NO: 153 (Ribosome binding site RBS2 and Sc_YEL020C (codon optimized) open reading frame):

GCATCAACTACCTTTATTATTCAACAAACCAATTTAACATATTAAAAAAATAAAAAA ATGACTA CCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCG GCAT AGTAGGTATTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTAT ACCG TGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAA CCTG GTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATA GTAT GTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAA GGGA GGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAA CTGA CGCCGGATAACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCG CCGG AGTGAGCTATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAA TGAT AGAACTGGTAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGT AAAA TTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAG GTAA AGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTT CCTT CCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCC CGGA GCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCC TTCA CTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCC GGAA ACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGA CTAT CGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAG TCAA ACAGGAGATCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAAC GCGT GGAGCTCAGCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTAT CGCA CGATCTTGGTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTG ATGC ACCTCGCAGAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGC ATTA GCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTC GGTT TTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAA TGAA TAACTCTGGGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTT GTCA AAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAAT ACCA TCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAA CCTC CGTCATTAATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAA CAAG CCTAGACTG [00310] SEQ ID NO: 154 (Ribosome binding site RBS3 and Sc YEL020C (codon optimized) open reading frame):

GCATCTACCCCTAACAACCCATAAATTTAACTTTAAAAAATTTTTAAATATAATAAA ATGACTA CCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCG GCAT AGTAGGTATTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTAT ACCG TGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAA CCTG GTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATA GTAT GTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAA GGGA GGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAA CTGA CGCCGGATAACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCG CCGG AGTGAGCTATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAA TGAT AGAACTGGTAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGT AAAA TTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAG GTAA AGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTT CCTT CCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCC CGGA GCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCC TTCA CTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCC GGAA ACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGA CTAT CGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAG TCAA ACAGGAGATCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAAC GCGT GGAGCTCAGCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTAT CGCA CGATCTTGGTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTG ATGC ACCTCGCAGAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGC ATTA GCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTC GGTT TTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAA TGAA TAACTCTGGGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTT GTCA AAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAAT ACCA TCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAA CCTC CGTCATTAATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAA CAAG CCTAGACTG [00311] SEQ ID NO: 155 (Ribosome binding site RBS4 and Sc_YEL020C (codon optimized) open reading frame):

GCATCATCTACCTTCATTATTAAACAAACCAAATTAATATCATAAAAAAATAAAAAA ATGACTA CCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCG GCAT AGTAGGTATTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTAT ACCG TGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAA CCTG GTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATA GTAT GTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAA GGGA GGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAA CTGA CGCCGGATAACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCG CCGG AGTGAGCTATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAA TGAT AGAACTGGTAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGT AAAA TTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAG GTAA AGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTT CCTT CCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCC CGGA GCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCC TTCA CTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCC GGAA ACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGA CTAT CGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAG TCAA ACAGGAGATCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAAC GCGT GGAGCTCAGCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTAT CGCA CGATCTTGGTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTG ATGC ACCTCGCAGAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGC ATTA GCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTC GGTT TTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAA TGAA TAACTCTGGGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTT GTCA AAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAAT ACCA TCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAA CCTC CGTCATTAATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAA CAAG CCTAGACTG

[00312] SEQ ID NO: 156 (Ribosome binding site RBS5 and Sc_YEL020C (codon optimized) open reading frame):

GCATCTACCCCTAACAACCCATAAATTTAACTTTTCTACAAAAAAAAATATAAAAAA ATGACTA CCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCG GCAT AGTAGGTATTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTAT ACCG TGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAA CCTG GTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATA GTAT GTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAA GGGA GGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAA CTGA CGCCGGATAACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCG CCGG AGTGAGCTATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAA TGAT AGAACTGGTAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGT AAAA TTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAG GTAA AGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTT CCTT CCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCC CGGA GCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCC TTCA CTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCC GGAA ACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGA CTAT CGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAG TCAA ACAGGAGATCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAAC GCGT GGAGCTCAGCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTAT CGCA CGATCTTGGTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTG ATGC ACCTCGCAGAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGC ATTA GCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTC GGTT TTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAA TGAA TAACTCTGGGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTT GTCA AAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAAT ACCA TCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAA CCTC CGTCATTAATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAA CAAG CCTAGACTG [00313] SEQ ID NO: 157 (Ribosome binding site RBS6 and Sc_YEL020C (codon optimized) open reading frame):

GCATCACCTACCTACATTAATAACCATACCATCTCAGTTTTAAATAAATTTTAAAAA ATGACTA CCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCG GCAT AGTAGGTATTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTAT ACCG TGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAA CCTG GTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATA GTAT GTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAA GGGA GGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAA CTGA CGCCGGATAACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCG CCGG AGTGAGCTATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAA TGAT AGAACTGGTAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGT AAAA TTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAG GTAA AGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTT CCTT CCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCC CGGA GCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCC TTCA CTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCC GGAA ACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGA CTAT CGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAG TCAA ACAGGAGATCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAAC GCGT GGAGCTCAGCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTAT CGCA CGATCTTGGTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTG ATGC ACCTCGCAGAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGC ATTA GCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTC GGTT TTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAA TGAA TAACTCTGGGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTT GTCA AAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAAT ACCA TCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAA CCTC CGTCATTAATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAA CAAG CCTAGACTG [00314] SEQ ID NO: 158 (Ribosome binding site RBS7 and Sc_YEL020C (codon optimized) open reading frame):

GCATCACCTACCTTAATTAATCACCATTCCATATCCTTTCAAAAAAAATATAAAAAA ATGACTA CCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCG GCAT AGTAGGTATTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTAT ACCG TGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAA CCTG GTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATA GTAT GTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAA GGGA GGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAA CTGA CGCCGGATAACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCG CCGG AGTGAGCTATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAA TGAT AGAACTGGTAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGT AAAA TTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAG GTAA AGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTT CCTT CCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCC CGGA GCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCC TTCA CTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCC GGAA ACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGA CTAT CGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAG TCAA ACAGGAGATCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAAC GCGT GGAGCTCAGCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTAT CGCA CGATCTTGGTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTG ATGC ACCTCGCAGAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGC ATTA GCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTC GGTT TTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAA TGAA TAACTCTGGGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTT GTCA AAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAAT ACCA TCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAA CCTC CGTCATTAATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAA CAAG CCTAGACTG

[00315] SEQ ID NO: 159 (Ribosome binding site RBS8 and Sc_YEL020C (codon optimized) open reading frame):

GCATCACCTACCTCTATTAATCATCATTCCAATTTAGGCTCATTAAATATTAGAAAA TGACTAC CACAGCAACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCGG CATA GTAGGTATTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTATA CCGT GTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAAC CTGG TGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATAG TATG TCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAAG GGAG GTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAAC TGAC GCCGGATAACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCGC CGGA GTGAGCTATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAAT GATA GAACTGGTAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGTA AAAT TAAGAAGGTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAGG TAAA GGAGCAGTGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTTC CTTC CGACTCCCATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCCC GGAG CCAGGCTCTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCCT TCAC TTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCCG GAAA CGCTCGGAGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGAC TATC GGTTACTGCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAGT CAAA CAGGAGATCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAACG CGTG GAGCTCAGCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTATC GCAC GATCTTGGTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTGA TGCA CCTCGCAGAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGCA TTAG CGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTCG GTTT TAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAAT GAAT AACTCTGGGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTTG TCAA AAAATTGTAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAATA CCAT CTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAAC CTCC GTCATTAATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAAC AAGC CTAGACTG [00316] SEQ ID NO: 160 (Ribosome binding site RBS1b and Sc_YEL020C (codon optimized) open reading frame):

GCATCATCTACCTTAATTAATCAACAAACCAATTACCAACCTAAAAAATATAAGAAA ATGACTA CCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCG GCAT AGTAGGTATTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTAT ACCG TGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAA CCTG GTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATA GTAT GTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAA GGGA GGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAA CTGA CGCCGGATAACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCG CCGG AGTGAGCTATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAA TGAT AGAACTGGTAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGT AAAA TTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAG GTAA AGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTT CCTT CCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCC CGGA GCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCC TTCA CTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCC GGAA ACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGA CTAT CGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAG TCAA ACAGGAGATCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAAC GCGT GGAGCTCAGCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTAT CGCA CGATCTTGGTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTG ATGC ACCTCGCAGAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGC ATTA GCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTC GGTT TTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAA TGAA TAACTCTGGGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTT GTCA AAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAAT ACCA TCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAA CCTC CGTCATTAATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAA CAAG CCTAGACTG [00317] SEQ ID NO: 161 (Ribosome binding site RBS2b and Sc_YEL020C (codon optimized) open reading frame):

GCATCAACTACCTTTATTATTCAACAAACCAATTTAACATAGTAAAAAAATAAAAAA ATGACTA CCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCG GCAT AGTAGGTATTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTAT ACCG TGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAA CCTG GTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATA GTAT GTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAA GGGA GGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAA CTGA CGCCGGATAACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCG CCGG AGTGAGCTATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAA TGAT AGAACTGGTAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGT AAAA TTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAG GTAA AGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTT CCTT CCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCC CGGA GCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCC TTCA CTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCC GGAA ACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGA CTAT CGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAG TCAA ACAGGAGATCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAAC GCGT GGAGCTCAGCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTAT CGCA CGATCTTGGTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTG ATGC ACCTCGCAGAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGC ATTA GCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTC GGTT TTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAA TGAA TAACTCTGGGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTT GTCA AAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAAT ACCA TCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAA CCTC CGTCATTAATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAA CAAG CCTAGACTG [00318] SEQ ID NO: 162 (Ribosome binding site RBS3b and Sc_YEL020C (codon optimized) open reading frame):

GCATCTACCCCTAACAACCCATAAATTTAACTTTAAAAAATTTTTAAATATAAGAAA ATGACTA CCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGATACTGTCTTCG GCAT AGTAGGTATTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTAAGTTTAT ACCG TGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTCGGACAAA CCTG GTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATCTATAATA GTAT GTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACATCCACAA GGGA GGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCACTGGTAAA CTGA CGCCGGATAACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAGGGAACCG CCGG AGTGAGCTATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTGAGGGCAA TGAT AGAACTGGTAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGACCCCAGT AAAA TTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATAGTGATAG GTAA AGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACTTGCCGTT CCTT CCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAGCAGCGCC CGGA GCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAATTGGATCC TTCA CTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACAGTAACCC GGAA ACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGACATCGGA CTAT CGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATACTCGGGAG TCAA ACAGGAGATCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGGAAAAAAC GCGT GGAGCTCAGCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGACGACTAT CGCA CGATCTTGGTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTTCCGACTG ATGC ACCTCGCAGAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAGGTTACGC ATTA GCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAGTGCCTTC GGTT TTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATTGTCGTAA TGAA TAACTCTGGGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGACCGCTTT GTCA AAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTTCGTCAAT ACCA TCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAGCGCGAAA CCTC CGTCATTAATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCATGGCAAAA CAAG CCTAGACTG [00319] SEQ ID NO: 163 (Oxalyl-CoA decarboxylase (OXC) from Saccharomyces cerevisiae S288C; EC 4.1.1.8; UniProt Accession P39994; Sc_YEL020C; Codon optimized):

ATGACTACCACAGCAACGCAGCATTTTGCCCAGTTACTCCAGAAGTACGGAATTGAT ACTGTCT TCGGCATAGTAGGTATTCCGATCGTGCAGTTGGCCGACACTATGGTCGCGAATGGAATTA AGTT TATACCGTGTCGCAATGAGCAAGCCGCAAGTTACGCGGCAAGCGCCTACGGCTACATCTC GGAC AAACCTGGTGTCCTGTTAATCGTGGGAGGGCCTGGCCTTATTCATGCCTTAGCGGGGATC TATA ATAGTATGTCGAACCGCTGGCCCTTGTTGGTCATCGCCGGATCCAGCAGCCAGTCAGACA TCCA CAAGGGAGGTTTCCAGGAACTTGACCAGGTGTCCTTGCTAAGTCCGTTCCTAAAATTCAC TGGT AAACTGACGCCGGATAACATCGATATGATAACCCAAAAAGCACTCAACTATTGCATTCAG GGAA CCGCCGGAGTGAGCTATATCGATGTCCCCGCTGACTTCATCGAATACGAGAAGCCGCTTG AGGG CAATGATAGAACTGGTAACGAGCTGCCAATGATCCTGACGCCCAATATCTGCGGTCCAGA CCCC AGTAAAATTAAGAAGGTGGTGCAATTGATACTCCAGCACAAGAACAAGAACATATTAATA GTGA TAGGTAAAGGAGCAGTGAAGAATAGCCATGAGATTAGACGCTTGGTTAACACCTTTAACT TGCC GTTCCTTCCGACTCCCATGGCGAAAGGCATAGTGCCCGATAGCAGCCCTTTAAATGTGAG CAGC GCCCGGAGCCAGGCTCTTAAGATTGCTGACATCGTGTTAGTATTGGGAGCTCGCCTGAAT TGGA TCCTTCACTTCGGAACGAGTCCAAAGTGGAATAGCGAGAGTATTTTTATACAATTTGACA GTAA CCCGGAAACGCTCGGAGACAATAACGTTAGTCCCGGAGCAGATTTAAGTATCTGGGGGGA CATC GGACTATCGGTTACTGCACTGGTAGAAGAGCTCACGAGACAGGACAGTTGTTGGAAATAC TCGG GAGTCAAACAGGAGATCAGGGAAAAGATACAGTTAAACCAGACCAGATTGCTCCGTAAGG AAAA AACGCGTGGAGCTCAGCTTAACTATAATCAAGTGTACGGCACCCTTCGTCCGTTAATTGA CGAC TATCGCACGATCTTGGTCACAGAAGGTGCCAACACAATGGACATCGCTAGAATAAGTTTT CCGA CTGATGCACCTCGCAGAAGACTTGATGCTGGTACAAATGCTACAATGGGTATAGGTTTAG GTTA CGCATTAGCGTGTAAAGCCAGCCACCCTGAGTTAGACGTTGTTTTAATCCAAGGCGACAG TGCC TTCGGTTTTAGCGCTATGGAGATCGAGACTGCCGTCCGTTGCCAATTAGCCCTTGTGATT GTCG TAATGAATAACTCTGGGATATATCACGGTGAGAAAGACATCGAAGGAGATCTGCCCCCGA CCGC TTTGTCAAAAAATTGTAGATATGACTTGGTCGGTAAGGGTTTAGGAGCTAACGACTTCTT CGTC AATACCATCTCAGAGTTATCTCGCTGTTTTCAGCAGGCAGTTCAATTGAGCAGAACCAAG CGCG AAACCTCCGTCATTAATGTCATAATCGAACCGGGAGAGCAGAAACAGATCGCGTTCGCAT GGCA AAACAAGCCTAGACTG [00320] SEQ ID NO: 164 (Ribosome binding site):

GCATCTAAACTAAAATACAATAACCAAAAATCATTACAAATGAAAAAAAATAATAAA [00321] SEQ ID NO: 165 (Ribosome binding site):

GCATCTAAACTAAAATACAATAACCAAAAATCATGTTTAACAAATAAAAATAATAAA [00322] SEQ ID NO: 166 (Ribosome binding site):

GCATCTAAACTAAAATACAATAACCAAAAATCATCTATGCGTAAAAAAAATTATAAA [00323] SEQ ID NO: 167 (Ribosome binding site):

GCATCTAAACTAAAATACAATAACCAAAAATCATACTACATGTATAAAATTAAAAAA [00324] SEQ ID NO: 168 (Ribosome binding site):

GCATCTAAACTAAAATACAATAACCAAAAATCATTTTCACAATATAAAAATAACAAA [00325] SEQ ID NO: 169 (Ribosome binding site):

GCATCATCTACCTCAATTATTCACCATTCCATCTGTCTAGCCAAAAAATTTAAAAAA

[00326] SEQ ID NO: 170 (Ribosome binding site):

GCATCATCTACCTAAATTACTCATCATCCCATTTTAGTCAGCTTAAAATATTATAAA

[00327] SEQ ID NO: 171 (Ribosome binding site):

GCATCATCTACCTATATTATTTATCATTCCATATCATGCGTGAATAAAAATAATAAA

[00328] SEQ ID NO: 172 (Ribosome binding site):

GCATCATCTACCTATATTAATCATCAACCCAATTTTCATATGTATAAAATTAACAAA

[00329] SEQ ID NO: 173 (Ribosome binding site):

GCATCTTTTCCATAACAAAAATTAAACCTCCTCCATATGAAAAATAAAAATTATAAA

[00330] SEQ ID NO: 174 (Ribosome binding site):

GCATCAACTACCTCAATTAATAATCAAACCATCTGAACAATGAATAAATTTAAAAAA

[00331] SEQ ID NO: 175 (Ribosome binding site):

GCATCTTTTCCATAACAAAAATTAAACCTCCTCCATATGAGATATAAAATTAACAAA

[00332] SEQ ID NO: 176 (Ribosome binding site):

GCATCAACTACCTTAATTATTCATCAAACCATATAACATACTAAAAAAAATAACAAA

[00333] SEQ ID NO: 177 (Ribosome binding site):

GCATCATCTACCTATATTACTAATCATTCCAATTAATTACCTTATAAAATTAAGAAA

[00334] SEQ ID NO: 178 (Ribosome binding site):

GCATCTTTTCCATAACAAAAATTAAACCTCCTCCCCCCCACGTTTAAAATTAAAAAA

[00335] SEQ ID NO: 179 (Ribosome binding site):

GCATCAACTACCTTCATTACTTAACAATCCACCTGTTGTGAGTAAAAATATAAGAAA

[00336] SEQ ID NO: 180 (Ribosome binding site):

GCATCCCCAAAAAATTAATTCATTTTCTCTTTTCCCTAACCCTTAAAATATAATAAA

[00337] SEQ ID NO: 181 (Ribosome binding site):

GCATCAACTACCTAAATTAATTATCACCCCAAATTAATAACATAAAAATATAATAAA

[00338] SEQ ID NO: 182 (Ribosome binding site):

GCATCAACTACCTAAATTAATTATCACCCCAAATTAATAACATAAAAATATAATAAA

[00339] SEQ ID NO: 183 (Ribosome binding site):

GCATCCCCAAAAAATTAATTCATTTTCTCTTTTCAACAATTTAAAAAAAATTAAAAA [00340] SEQ ID NO: 184 (Ribosome binding site):

GCATCCCCAAAAAATTAATTCATTTTCTCTTTTCGATCCTATAAAAAATATAACAAA

[00341] SEQ ID NO: 185 (Ribosome binding site):

GCATCATCTACCTTTATTATTAATCAATCCATCTCAGTAAGTTTAAAATATAACAAA

[00342] SEQ ID NO: 186 (Ribosome binding site):

GCATCAACTACCTCTATTAATAATCAATCCACATCTTGATCGTAAAAAATTTAAAAA

[00343] SEQ ID NO: 187 (Ribosome binding site):

GCATCACCTACCTAAATTACTAAACAAACCACCTGCATTTGTTTTAAAAATTACAAA

[00344] SEQ ID NO: 188 (Ribosome binding site):

GCATCAACTACCTAAATTAATCATCAAACCAACTAGAATATGAAAAAAAATAAAAAA

[00345] SEQ ID NO: 189 (Ribosome binding site):

GCATCAACTACCTCAATTAATAAACAAACCAACTGTCCAATGTATAAAATTAAAAAA

[00346] SEQ ID NO: 190 (Ribosome binding site):

GCATCAACTACCTCAATTACTAAACAATCCACATTATTAATATAAAAATATAAAAAA

[00347] SEQ ID NO: 191 (Ribosome binding site):

GCATCAACACCTAAATTAATTAACACACCATATATTAAACCATAAAAAATAAGAAA

[00348] SEQ ID NO: 192 (Ribosome binding site):

GCATCTTCTACCCATATTCCCCCTAATCCCATCTGTTATATTATTAAATTTAATAAA

[00349] SEQ ID NO: 193 (Ribosome binding site):

GCATCATCTACCTACATTATTTAACAAACCACATTTAAAAGGAAAAAATATTAAAAA

[00350] SEQ ID NO: 194 (Ribosome binding site):

GCATCACCTACCTATATTATTTATCATTCCACATGCGTTATTATTAAATTTTAAAAA

[00351] SEQ ID NO: 195 (Ribosome binding site):

GCATCTAAACAACATATTCCCCCTAAACCAAAATATTTAGGGTATAAAAATTAAAAA

[00352] SEQ ID NO: 196 (Ribosome binding site):

GCATCATCTACCTTTATTAATCAACAATCCAAATTATTAATAAAAAAAATTTAAAAA

[00353] SEQ ID NO: 197 (Ribosome binding site):

GCATCAACTACCTAAATTACTTATCAAACCACTTAGTAGTAAAAAAAATATAACAAA

[00354] SEQ ID NO: 198 (Ribosome binding site):

GCATCACTATTACAAAAAAAACACCAATATTACATGGTCTCTTTTAAATATTATAAA

[00355] SEQ ID NO 199 (Rib bi di it ) GCATCATCTACCTATATTACTAAACAAACCAATTATAATAATTTTAAAAATAAAAAA

[00356] SEQ ID NO: 200 (Ribosome binding site):

GCATCACCTACCTCTATTACTAATCAAACCATTTAAATGTAGTAAAAATATAATAAA

[00357] SEQ ID NO: 201 (Ribosome binding site):

GCATCAACTACCTAAATTAATAAACACACCAACTTCCATGAATAAAAATATAAAAAA

[00358] SEQ ID NO: 202 (Ribosome binding site):

GCATCATCTACCTATATTATTTACCACCCCACCTAACTTTAGATTAAAATTTACAAA

[00359] SEQ ID NO: 203 (Ribosome binding site):

GCATCACCTACCTTCATTACTCACCATACCAACTAGCACAGTTATAAAAATAAGAAA

[00360] SEQ ID NO: 204 (Ribosome binding site):

GCATCATCTACCTAAATTAATAAACAACCCATTTATAAACCCTTTAAAATTAACAAA

[00361] SEQ ID NO: 205 (Ribosome binding site):

GCATCTTAATCAATTTTAAACTCACCAAATCAAAATATGAAAAAAAAAAATAATAAA

[00362] SEQ ID NO: 206 (Ribosome binding site):

GCATCATCTACCTTAATTAATAAACAAACCAATTTAACTAATTTAAAAAATATAAA

[00363] SEQ ID NO: 207 (Ribosome binding site):

GCATCATCTACCTTCATTATTAATCATTCCAATTGTATCACTTAAAAATATAAAAAA

[00364] SEQ ID NO: 208 (Ribosome binding site):

GCATCTTAATCAATTTTAAACTCACCAAATCAAATATCACGTAAAAAATATAAGAAA

[00365] SEQ ID NO: 209 (Ribosome binding site):

GCATCAACTACCTCAATTATTTAACACACCAATTACTATACGTAAAAATATAAAAAA

[00366] SEQ ID NO: 210 (Ribosome binding site):

GCATCTTAATCAATTTTAAACTCACCAAATCAAAAAAATGCGTATAAAAATTAAAAA

[00367] SEQ ID NO: 211 (Ribosome binding site):

GCATCTTAATCAATTTTAAACTCACCAAATCAAAGGCCGACTTAAAAATATTAGAAA

[00368] SEQ ID NO: 212 (Ribosome binding site):

GCATCACCTAAAAATTATAAATAAATTAATAAACCTTTTAACATAAAAATTAATAAA

[00369] SEQ ID NO: 213 (Ribosome binding site):

GCATCACCTAAAAATTATAAATAAATTAATAAACTTTTATTAAAAAAAAATTACAAA

[00370] SEQ ID NO: 214 (Ribosome binding site):

GCATCACCTAAAAATTATAAATAAATTAATAAACATAACATAAATAAAATTAATAAA [00371] SEQ ID NO: 215 (Ribosome binding site):

GCATCACCTAAAAATTATAAATAAATTAATAAACCACAATACTAAAAATTTAATAAA

[00372] SEQ ID NO: 216 (Ribosome binding site):

GCATCAACTACCTACATTAATAACCAACCCAAATGCCTAATCAATAAATATTATAAA

[00373] SEQ ID NO: 217 (Ribosome binding site):

GCATCATCTACCTATATTATTCATCAAACCATTTGATCCAACATTAAATATTAAAAA

[00374] SEQ ID NO: 218 (Ribosome binding site):

GCATCACCTACCTCAATTATTAATCATACCAACTGGATTTGATTTAAAAATAAGAAA

[00375] SEQ ID NO: 219 (Ribosome binding site):

GCATCACCTACCTTTATTACTCATCATACCAAATGGTAGCGGATTAAATATTAGAAA

[00376] SEQ ID NO: 220 (Ribosome binding site):

GCATCATCTACCTTAATTAATCAACAAACCAATTACCAACCTAAAAAATATAAGAAA

[00377] SEQ ID NO: 221 (Ribosome binding site):

GCATCAACTACCTTTATTATTCAACAAACCAATTTAACATATTAAAAAAATAAAAAA

[00378] SEQ ID NO: 222 (Ribosome binding site):

GCATCTACCCCTAACAACCCATAAATTTAACTTTAAAAAATTTTTAAATATAATAAA

[00379] SEQ ID NO: 223 (Ribosome binding site):

GCATCATCTACCTTCATTATTAAACAAACCAAATTAATATCATAAAAAAATAAAAAA

[00380] SEQ ID NO: 224 (Ribosome binding site):

GCATCTACCCCTAACAACCCATAAATTTAACTTTTCTACAAAAAAAAATATAAAAAA

[00381] SEQ ID NO: 225 (Ribosome binding site):

GCATCACCTACCTACATTAATAACCATACCATCTCAGTTTTAAATAAATTTTAAAAA

[00382] SEQ ID NO: 226 (Ribosome binding site):

GCATCACCTACCTTAATTAATCACCATTCCATATCCTTTCAAAAAAAATATAAAAAA

[00383] SEQ ID NO: 227 (Ribosome binding site):

GCATCACCTACCTCTATTAATCATCATTCCAATTTAGGCTCATTAAATATTAGAAA

[00384] SEQ ID NO: 228 (Ribosome binding site):

GCATCATCTACCTTAATTAATCAACAAACCAATTACCAACCTAAAAAATATAAGAAA

[00385] SEQ ID NO: 229 (Ribosome binding site):

GCATCAACTACCTTTATTATTCAACAAACCAATTTAACATAGTAAAAAAATAAAAAA [00386] SEQ ID NO: 230 (Ribosome binding site):

GCATCTACCCCTAACAACCCATAAATTTAACTTTAAAAAATTTTTAAATATAAGAAA