Title:
METHODS AND COMPOSITIONS FOR TREATING PLATELET-RELATED DISORDERS USING MPL PATHWAY INHIBITORY AGENTS
Document Type and Number:
WIPO Patent Application WO2001021163
Kind Code:
A3
Abstract:
The invention relates to the treatment of subjects for the purpose inhibiting vaso-occlusive events, including thrombosis and embolism, by administering agents which reduce the number of circulating platelets to low or below normal levels. Methods and pharmaceutical preparations comprising such agents are provided.
Inventors:
HANSON STEPHEN R
Application Number:
PCT/US2000/026025
Publication Date:
March 07, 2002
Filing Date:
September 21, 2000
Export Citation:
Assignee:
UNIV EMORY (US)
International Classes:
A61K45/00; A61K31/00; A61K31/4365; A61K31/519; A61K31/60; A61K31/616; A61K31/726; A61K38/16; A61K38/36; A61K38/48; A61K38/49; A61K45/06; A61P3/06; A61P7/02; A61P9/10; A61P9/12; A61P9/14; A61P11/00; A61P13/12; A61P27/14; A61P43/00; A61K9/00; A61K9/06; A61K9/20; A61K47/28; (IPC1-7): A61K31/00; A61P7/02
Domestic Patent References:
| WO1999010494A2 | 1999-03-04 |
Foreign References:
| US5830647A | 1998-11-03 |
Other References:
VANDERLOO B ET AL: "A role for changes in platelet production in the cause of acute coronary syndromes", ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, (MAR 1999) VOL. 19, NO. 3, PP. 672-679. PUBLISHER: LIPPINCOTT WILLIAMS & WILKINS, 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106. ISSN: 1079-5642., UNIV COLL LONDON, 140 TOTTENHAM COURT RD, LONDON W1P 9LN, ENGLAND (Reprint);UNIV COLL LONDON, LONDON W1P 9LN, ENGLAND, XP000998074
HARKER L A (REPRINT): "Platelets in thrombotic disorders: Quantitative and qualitative platelet disorders predisposing to arterial thrombosis", SEMINARS IN HEMATOLOGY, (JUL 1998) VOL. 35, NO. 3, PP. 241-252. PUBLISHER: W B SAUNDERS CO, INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399. ISSN: 0037-1963., EMORY UNIV, SCH MED, DIV HEMATOL & ONCOL, YERKES REG PRIMATE RES CTR, 163 PIERCE DR, ROOM 1003, ATLANTA, GA 30322 (Reprint), XP000998072
VANDERLOO B (REPRINT) ET AL: "Megakaryocytes and platelets in vascular disease", BAILLIERES CLINICAL HAEMATOLOGY, (FEB 1997) VOL. 10, NO. 1, PP. 109-123. PUBLISHER: BAILLIERE TINDALL, 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX. ISSN: 0950-3536., UNIV COLL LONDON, CRUCIFORM PROJECT, BRITISH HEART FDN, 140 TOTTENHAM COURT RD, LONDON W1P 9LN, ENGLAND (Reprint);UNIV COLL LONDON, DEPT MED, BRITISH HEART FDN, LONDON W1P 9LN, ENGLAND, XP000998066
HARKER L A (REPRINT) ET AL: "REGULATION OF PLATELET PRODUCTION AND FUNCTION BY MEGAKARYOCYTE GROWTH AN DEVELOPMENT FACTOR IN NONHUMAN-PRIMATES", BLOOD, (01 MAR 1996) VOL. 87, NO. 5, PP. 1833-1844. ISSN: 0006-4971., EMORY UNIV, SCH MED, DIV HEMATOL & ONCOL, YERKES REG PRIMATE RES CTR, PO DRAWER AR, ATLANTA, GA, 30322 (Reprint);AMGEN INC, THOUSAND OAKS, CA, 91320, XP000998079
HARKER L A (REPRINT): "Platelets in thrombotic disorders: Quantitative and qualitative platelet disorders predisposing to arterial thrombosis", SEMINARS IN HEMATOLOGY, (JUL 1998) VOL. 35, NO. 3, PP. 241-252. PUBLISHER: W B SAUNDERS CO, INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399. ISSN: 0037-1963., EMORY UNIV, SCH MED, DIV HEMATOL & ONCOL, YERKES REG PRIMATE RES CTR, 163 PIERCE DR, ROOM 1003, ATLANTA, GA 30322 (Reprint), XP000998072
VANDERLOO B (REPRINT) ET AL: "Megakaryocytes and platelets in vascular disease", BAILLIERES CLINICAL HAEMATOLOGY, (FEB 1997) VOL. 10, NO. 1, PP. 109-123. PUBLISHER: BAILLIERE TINDALL, 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX. ISSN: 0950-3536., UNIV COLL LONDON, CRUCIFORM PROJECT, BRITISH HEART FDN, 140 TOTTENHAM COURT RD, LONDON W1P 9LN, ENGLAND (Reprint);UNIV COLL LONDON, DEPT MED, BRITISH HEART FDN, LONDON W1P 9LN, ENGLAND, XP000998066
HARKER L A (REPRINT) ET AL: "REGULATION OF PLATELET PRODUCTION AND FUNCTION BY MEGAKARYOCYTE GROWTH AN DEVELOPMENT FACTOR IN NONHUMAN-PRIMATES", BLOOD, (01 MAR 1996) VOL. 87, NO. 5, PP. 1833-1844. ISSN: 0006-4971., EMORY UNIV, SCH MED, DIV HEMATOL & ONCOL, YERKES REG PRIMATE RES CTR, PO DRAWER AR, ATLANTA, GA, 30322 (Reprint);AMGEN INC, THOUSAND OAKS, CA, 91320, XP000998079
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