METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS

Title:

METHODS AND COMPOSITIONS FOR TREATING RHEUMATOID ARTHRITIS

Document Type and Number:

WIPO Patent Application WO2005000246

Kind Code:

A3

Abstract:

This application relates to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and an antibody to alpha 4 integrin or an immunologically active antigen binding fragment in therapeutically effective amounts. The application also relates generally to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and small molecule alpha-4 integrin antagonist that inhibits the alpha-4 integrin ( 4 integrin) interaction with VCAM-1. The invention further relates to methods of preparing the compounds and methods of using the compounds and compositions.

Inventors:

YEDNOCK THEODORE A (US)
FREEDMAN STEPHEN B (US)
LIEBERBURG IVAN (US)
PLEISS MICHAEL A (US)
KONRADI ANDREI W (US)
SHOPP GEORGE (US)
MESSERSMITH ELIZABETH (US)

Application Number:

PCT/US2004/020280

Publication Date:

November 24, 2005

Filing Date:

June 25, 2004

Export Citation:

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Assignee:

ELAN PHARM INC (US)
YEDNOCK THEODORE A (US)
FREEDMAN STEPHEN B (US)
LIEBERBURG IVAN (US)
PLEISS MICHAEL A (US)
KONRADI ANDREI W (US)
SHOPP GEORGE (US)
MESSERSMITH ELIZABETH (US)

International Classes:

A61K31/16; A61K31/18; A61K31/195; A61K31/40; A61K31/415; A61K31/425; A61K31/44; A61K31/519; A61K31/525; A61K38/00; A61K39/00; A61K39/395; A61K; (IPC1-7): A61K31/415; A61K31/425; A61K31/18; A61K31/16

Foreign References:

US6489300B1

2002-12-03

Other References: