Title:
METHODS AND COMPOSITIONS FOR TREATMENT OF VIRAL DISEASES
Document Type and Number:
WIPO Patent Application WO2005016288
Kind Code:
A3
Abstract:
The present invention provides methods of treating alphavirus infection; methods of treating hepatitis C virus (HCV) infection; methods of treating West Nile virus infection; methods of reducing liver fibrosis; methods of increasing liver function in an individual suffering from liver fibrosis; methods of reducing the incidence of complications associated with HCV and cirrhosis of the liver; and methods of reducing viral load, or reducing the time to viral clearance, or reducing morbidity or mortality in the clinical outcomes, in patients suffering from viral infection. The methods generally involve administering to a subject in need thereof an effective dosage of an interferon receptor agonist, either alone or in combination therapy with ribavirin.
Inventors:
BLATT LAWRENCE M (US)
Application Number:
PCT/US2004/005952
Publication Date:
July 07, 2005
Filing Date:
February 26, 2004
Export Citation:
Assignee:
INTERMUNE INC (US)
BLATT LAWRENCE M (US)
BLATT LAWRENCE M (US)
International Classes:
A01N1/02; A61K31/7056; A61K35/00; A61K38/00; A61K38/19; A61K38/21; A61P31/12; A61K; (IPC1-7): A61K35/00; A61K38/19; A61K38/00; A01N1/02
Foreign References:
| US5767097A | 1998-06-16 |
Other References:
ARASE Y. ET AL.: "Annual review shokaki", January 1998 (1998-01-01), pages 237 - 242
SUZUKI H. ET AL.: "Therapy of viral hepatitis in Japan-present and future", ANTI-BIOTICS & CHEMOTHERAPY, vol. 15, no. 3, 1999, pages 353 - 360
KOTENKO S.V. ET AL.: "INF-lambda s mediate antiviral protection through a distinct class II cytokine receptor complex", NATURE IMMUNOLOGY, vol. 4, no. 1, January 2003 (2003-01-01), pages 69 - 77, XP008040607
SHAPPARD P. ET AL.: "IL-28, IL-29 and their class II cytokine receptor IL-28R", NATURE IMMUNOLOGY, vol. 4, no. 1, January 2003 (2003-01-01), pages 63 - 68, XP002261756
OKU H. ET AL.: "Pirfenidone suppresses tumor necrosis factor alfa, enhances interleukine-10 and protects mice from endotoxic shock", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 226, no. 103, June 2002 (2002-06-01), pages 167 - 176
SUZUKI H. ET AL.: "Therapy of viral hepatitis in Japan-present and future", ANTI-BIOTICS & CHEMOTHERAPY, vol. 15, no. 3, 1999, pages 353 - 360
KOTENKO S.V. ET AL.: "INF-lambda s mediate antiviral protection through a distinct class II cytokine receptor complex", NATURE IMMUNOLOGY, vol. 4, no. 1, January 2003 (2003-01-01), pages 69 - 77, XP008040607
SHAPPARD P. ET AL.: "IL-28, IL-29 and their class II cytokine receptor IL-28R", NATURE IMMUNOLOGY, vol. 4, no. 1, January 2003 (2003-01-01), pages 63 - 68, XP002261756
OKU H. ET AL.: "Pirfenidone suppresses tumor necrosis factor alfa, enhances interleukine-10 and protects mice from endotoxic shock", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 226, no. 103, June 2002 (2002-06-01), pages 167 - 176
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