Title:
METHODS FOR DETECTING L-FICOLIN DEPENDENT ACTIVATION OF THE LECTIN PATHWAY OF COMPLEMENT AND KITS THEREFOR
Document Type and Number:
WIPO Patent Application WO2005051662
Kind Code:
A3
Abstract:
The invention provides methods, assays and kits for detecting L-ficolin dependent activation of the lectin pathway of complement and for identifying L-ficolin abnormalities. Also provided are methods for detection of gram positive bacteria based on the interaction between L-ficolin complexes and LTA.
Inventors:
LYNCH NICHOLAS (GB)
SCHWAEBLE WILHELM (GB)
SCHWAEBLE WILHELM (GB)
Application Number:
PCT/GB2004/050030
Publication Date:
December 08, 2005
Filing Date:
November 25, 2004
Export Citation:
Assignee:
UNIV LEICESTER (GB)
LYNCH NICHOLAS (GB)
SCHWAEBLE WILHELM (GB)
LYNCH NICHOLAS (GB)
SCHWAEBLE WILHELM (GB)
International Classes:
C07K14/47; C07K16/18; G01N33/564; G01N33/569; (IPC1-7): G01N33/564; G01N33/569; C07K14/47; C07K16/18
Domestic Patent References:
| WO2002045742A2 | 2002-06-13 |
Foreign References:
| US6297024B1 | 2001-10-02 |
Other References:
LYNCH N.J. ET AL.: "L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement.", J. IMMUNOL., vol. 172, no. 2, 15 January 2004 (2004-01-15), pages 1198 - 1202, XP002344076
NETH O. ET AL.: "Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus.", J. IMMUNOL., vol. 169, 15 October 2002 (2002-10-15), pages 4430 - 4436, XP002344077
NETH O. ET AL.: "Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus.", J. IMMUNOL., vol. 169, 15 October 2002 (2002-10-15), pages 4430 - 4436, XP002344077
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