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Title:
METHODS FOR DETERMINING MULTIPLE EFFECTS OF DRUGS THAT MODULATE FUNCTION OF TRANSCRIPTION REGULATORY PROTEINS
Document Type and Number:
WIPO Patent Application WO2003033744
Kind Code:
A9
Abstract:
Assays for determining the downstream effects of drugs that modulate the function of transcription regulatory proteins are disclosed. The assays comprise the steps of (a) providing cells that contain the transcription factor; (b) maintaining a control population and a test population of the cells under conditions that allow gene expression to occur in the cells, wherein the test population is exposed to the agent that modulates the activity of the transcription factor; (c) generating a gene expression profile for each of the control population and the test population of cells; and (d) comparing the gene expression profile from the control population of cells with the gene expression profile from the test population of cells; those differences being attributable to the effect of the agent that modulates the activity of the transcription factor. The assays are useful for classifying candidate transcription factor-modulating drugs on the basis of downstream gene expression effects, the thereafter correlating observed downstream effects with physiological markers of drug efficacy or side effects.

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Inventors:
NOTTERMAN DANIEL (US)
SHENK THOMAS E (US)
Application Number:
PCT/US2002/033406
Publication Date:
June 17, 2004
Filing Date:
October 18, 2002
Export Citation:
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Assignee:
UNIV PRINCETON (US)
NOTTERMAN DANIEL (US)
SHENK THOMAS E (US)
International Classes:
C12Q1/68; C12Q1/6809; (IPC1-7): C12Q1/68; G01N33/566
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