Title:
METHODS FOR DIAGNOSIS AND TREATMENT OF DISEASES ASSOCIATED WITH ALTERED EXPRESSION OF JAK1
Document Type and Number:
WIPO Patent Application WO2003027295
Kind Code:
A3
Abstract:
The present invention relates to novel compositions and methods related to JAKI for use in diagnosis and treatment of lymphoma and leukemia. In addition, the present invention describes the use of such novel compositions for use in screening methods.
Inventors:
PEDERSEN FINN SKOU (DK)
SORENSEN ANNETTE BALLE (DK)
HERNANDEZ JAVIER MARTIN (DK)
SORENSEN ANNETTE BALLE (DK)
HERNANDEZ JAVIER MARTIN (DK)
Application Number:
PCT/IB2002/004197
Publication Date:
October 16, 2003
Filing Date:
September 24, 2002
Export Citation:
Assignee:
UNIV AARHUS (DK)
PEDERSEN FINN SKOU (DK)
SORENSEN ANNETTE BALLE (DK)
HERNANDEZ JAVIER MARTIN (DK)
PEDERSEN FINN SKOU (DK)
SORENSEN ANNETTE BALLE (DK)
HERNANDEZ JAVIER MARTIN (DK)
International Classes:
C07K14/47; C12N15/54; (IPC1-7): C12N15/54; A61K38/45; C07K16/40; C12N9/12; C12N15/63; C12Q1/68; G01N33/50
Domestic Patent References:
| WO1999054286A2 | 1999-10-28 | |||
| WO1998053103A1 | 1998-11-26 | |||
| WO1997003358A1 | 1997-01-30 | |||
| WO2001017995A1 | 2001-03-15 | |||
| WO2002070742A1 | 2002-09-12 | |||
| WO2002060492A1 | 2002-08-08 | |||
| WO2002060927A1 | 2002-08-08 | |||
| WO2003026641A2 | 2003-04-03 |
Foreign References:
| US5821069A | 1998-10-13 |
Other References:
YANG XIANJIE ET AL: "Molecular cloning of the murine JAK1 protein tyrosine kinase and its expression in the mouse central nervous system.", JOURNAL OF NEUROSCIENCE, vol. 13, no. 7, 1993, pages 3006 - 3017, XP008019210, ISSN: 0270-6474
WILKS A F ET AL: "TWO NOVEL PROTEIN-TYROSINE KINASES, EACH WITH A SECOND PHOSPHOTRANSFERASE-RELATED CATALYTIC DOMAIN, DEFINE A NEW CLASS OF PROTEIN KINASE", MOLECULAR AND CELLULAR BIOLOGY, WASHINGTON, DC, US, vol. 11, no. 4, 1 April 1991 (1991-04-01), pages 2057 - 2065, XP000672768, ISSN: 0270-7306
HOFMANN WOLF-K ET AL: "Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 98, no. 3, 1 August 2001 (2001-08-01), pages 787 - 794, XP002246867, ISSN: 0006-4971
ENDO T A ET AL: "A new protein containing an SH2 domain that inhibits JAK kinases", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 387, 26 June 1997 (1997-06-26), pages 921 - 924, XP002085492, ISSN: 0028-0836
YU C L ET AL: "Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD.: 1950) UNITED STATES 1 DEC 1997, vol. 159, no. 11, 1 December 1997 (1997-12-01), pages 5206 - 5210, XP002250016, ISSN: 0022-1767
ARINGER M ET AL: "Janus kinases and their role in growth and disease.", LIFE SCIENCES, vol. 64, no. 24, 7 May 1999 (1999-05-07), pages 2173 - 2186, XP002250017, ISSN: 0024-3205
TSOU ANN-PING ET AL: "Parallel hybridization analysis of multiple protein kinase genes: Identification of gene expression patterns characteristic of human hepatocellular carcinoma.", GENOMICS, vol. 50, no. 3, 15 June 1998 (1998-06-15), pages 331 - 340, XP002250070, ISSN: 0888-7543
WILKS A F ET AL: "TWO NOVEL PROTEIN-TYROSINE KINASES, EACH WITH A SECOND PHOSPHOTRANSFERASE-RELATED CATALYTIC DOMAIN, DEFINE A NEW CLASS OF PROTEIN KINASE", MOLECULAR AND CELLULAR BIOLOGY, WASHINGTON, DC, US, vol. 11, no. 4, 1 April 1991 (1991-04-01), pages 2057 - 2065, XP000672768, ISSN: 0270-7306
HOFMANN WOLF-K ET AL: "Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 98, no. 3, 1 August 2001 (2001-08-01), pages 787 - 794, XP002246867, ISSN: 0006-4971
ENDO T A ET AL: "A new protein containing an SH2 domain that inhibits JAK kinases", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 387, 26 June 1997 (1997-06-26), pages 921 - 924, XP002085492, ISSN: 0028-0836
YU C L ET AL: "Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD.: 1950) UNITED STATES 1 DEC 1997, vol. 159, no. 11, 1 December 1997 (1997-12-01), pages 5206 - 5210, XP002250016, ISSN: 0022-1767
ARINGER M ET AL: "Janus kinases and their role in growth and disease.", LIFE SCIENCES, vol. 64, no. 24, 7 May 1999 (1999-05-07), pages 2173 - 2186, XP002250017, ISSN: 0024-3205
TSOU ANN-PING ET AL: "Parallel hybridization analysis of multiple protein kinase genes: Identification of gene expression patterns characteristic of human hepatocellular carcinoma.", GENOMICS, vol. 50, no. 3, 15 June 1998 (1998-06-15), pages 331 - 340, XP002250070, ISSN: 0888-7543
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