Title:
METHODS AND DOSAGE FORMS WITH MODIFIED VISCOSITY LAYERS
Document Type and Number:
WIPO Patent Application WO2004064772
Kind Code:
A3
Abstract:
Dosage forms and methods for providing a modulated release of cyclobenzaprine are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma cyclobenzaprine concentrations when administered once per day. The composition of the delay layer and the composition of the drug layer are characterized by the viscosity of the hydrated delay layer remaining higher than the viscosity of the hydrated drug layer during operation in one embodiment. The result is greater uniformity in the release rate from the core providing a more optimal ascending release rate. In other embodiments, the hydrated delay layer has a viscosity that is lower than the viscosity of the hydrated drug layer as well as a hydrated delay layer that is substantially similar to the hydrated drug layer.
Inventors:
SUBRAMANIAN RAMKUMAR (US)
BARCLAY BRIAN L (US)
HATAMKHANY ZAHEDEH (US)
ZHANG YUXIANG (US)
GUMUCIO FERNANDO (US)
BARCLAY BRIAN L (US)
HATAMKHANY ZAHEDEH (US)
ZHANG YUXIANG (US)
GUMUCIO FERNANDO (US)
Application Number:
PCT/US2004/000531
Publication Date:
March 23, 2006
Filing Date:
January 09, 2004
Export Citation:
Assignee:
ALZA CORP (US)
International Classes:
A61K9/00; A61K9/24; A61K9/28; A61K9/52; A61K31/135; A61K31/55; A61K; (IPC1-7): A61K9/20
Foreign References:
| US6342249B1 | 2002-01-29 |
Other References:
A.M. RAZAGHI; J.B. SCHWARTZ: "Investigation of Cyclobenzaprine Hydrochloride Release from Oral Osmotic Delivery Systems containing a water-swellable polymer", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 28, no. 6, 2002, pages 631 - 639, XP008033488
RAZAGHI A M ET AL: "WATER ABSORPTION, SWELLING AND RUPTURE OF OSMOTIC TABLETS CONTAINING A WATER SWELLABLE POLYMER", PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE BIOACTIVE MATERIALS, vol. 27, 2000, pages 1298 - 1299, XP008033494, ISSN: 1022-0178
RAZAGHI A M ET AL: "WATER ABSORPTION, SWELLING AND RUPTURE OF OSMOTIC TABLETS CONTAINING A WATER SWELLABLE POLYMER", PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE BIOACTIVE MATERIALS, vol. 27, 2000, pages 1298 - 1299, XP008033494, ISSN: 1022-0178
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