METHODS FOR DOSING AND TREATMENT WITH A COMBINATION OF A CHECKPOINT INHIBITOR THERAPY AND A CAR T CELL THERAPY

Title:

METHODS FOR DOSING AND TREATMENT WITH A COMBINATION OF A CHECKPOINT INHIBITOR THERAPY AND A CAR T CELL THERAPY

Document Type and Number:

WIPO Patent Application WO/2022/212400

Kind Code:

A8

Abstract:

Provided herein are methods and uses of combination therapies involving a T cell therapy, e.g., a CAR T cell therapy, and a checkpoint inhibitor therapy, e.g. an anti-PD-1 antibody and/or an anti-LAG3 antibody, for treating subjects with cancers such as lymphomas, and related methods, uses, and articles of manufacture.

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Inventors:

TREDE NIKOLAUS SEBASTIAN (US)
SURYAWANSHI SATYENDRA (US)
AGRAWAL SHRUTI (US)
SRIVASTAVA SHIVANI (US)
PULHAM TIM (CH)
DESTEFANO JOE (US)
BRAND NICOLAS (CH)
DUBOWY RONALD (US)

Application Number:

PCT/US2022/022377

Publication Date:

November 02, 2023

Filing Date:

March 29, 2022

Export Citation:

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Assignee:

JUNO THERAPEUTICS INC (US)

International Classes:

A61K39/00; A61P35/00; C07K14/705; C07K14/725; C07K16/28

Attorney, Agent or Firm:

RICE, Rachel et al. (US)

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