METHODS OF DRUG DELIVERY TO HEPATOCYTES AND TREATMENT OF FLAVIVIRIDAE INFECTIONS

Title:

METHODS OF DRUG DELIVERY TO HEPATOCYTES AND TREATMENT OF FLAVIVIRIDAE INFECTIONS

Document Type and Number:

WIPO Patent Application WO2002015904

Kind Code:

B1

Abstract:

A method of delivering a drug to a hepatocyte includes a step in which a carboxamidine group-containing compound is provided to a hepatocyte having a transporter that transports the compound across the plasma membrane of the hepatocyte, wherein the transport of the compound is substantially not inhibited by ribavirin. Further contemplated methods include a method of inhibiting growth of a virus of a family of flaviviridae in a cell containing system, in which contemplated compounds are presented to a cell in the cell containing system.

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Inventors:

LAU JOHNSON (US)
HONG ZHI (US)

Application Number:

PCT/US2001/026057

Publication Date:

July 04, 2002

Filing Date:

August 21, 2001

Export Citation:

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Assignee:

ICN PHARMACEUTICALS (US)
LAU JOHNSON (US)
HONG ZHI (US)

International Classes:

A61K31/155; C12N7/06; A61K31/41; A61K31/7056; A61P1/16; A61P31/12; A61P31/14; A61P35/00; C07H19/056; (IPC1-7): A61K31/41

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