Title:
METHODS FOR IDENTIFYING DNA COPY NUMBER CHANGES
Document Type and Number:
WIPO Patent Application WO2004044225
Kind Code:
A3
Abstract:
Methods of identifying changes in genomic DNA copy number are disclosed. Methods for identifying homozygous deletions and genetic amplifications are disclosed. An array of probes designed to detect presence or absence of plurality of different sequences is also disclosed. The probes are designed to hybridize to sequences that are predicted to be present in a reduced complexity sample. The methods may be used to detect copy number changes in cancerous tissue compared to normal tissue. The methods may be used to diagnose cancer.
Inventors:
HUANG JING (US)
SHAPERO MICHAEL H (US)
JONES KEITH (US)
SHAPERO MICHAEL H (US)
JONES KEITH (US)
Application Number:
PCT/US2003/036018
Publication Date:
April 06, 2006
Filing Date:
November 12, 2003
Export Citation:
Assignee:
AFFYMETRIX INC (US)
International Classes:
G16B20/10; C12Q1/00; C12Q1/68; G01N33/48; G01N33/50; G16B25/20; C12Q; (IPC1-7): G01N33/48
Foreign References:
| US6432648B1 | 2002-08-13 | |||
| US20020165345A1 | 2002-11-07 | |||
| US20010034023A1 | 2001-10-25 | |||
| US6455280B1 | 2002-09-24 | |||
| US6268142B1 | 2001-07-31 |
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