Title:
METHODS FOR IMMOBILIZING MICROVESICLES, MEANS AND METHODS FOR DETECTING THEM, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/072410
Kind Code:
A3
Abstract:
The invention provides a method for immobilizing microvesicles to a coated surface using a laminar flow. Further provided are a chip mould for the preparation of microfluidic chips suitable for use in the method and uses thereof. Further provided is a microfluidic chip suitable for use of the method. Further provided is a coated surface suitable for use of the method and uses thereof. Further provided are means and methods for detecting microvesicles and uses thereof for detecting or determining diseases related to microvesicles. Further is provided a kit suitable for use of the method, comprising of a microfluidic chip and a coated surface.
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Inventors:
OSANTO SUSANNE (NL)
BERTINA ROGIER MARIA (NL)
YUANA YUANA (NL)
OOSTERKAMP TJERK HENDRIK (NL)
ASHCROFT BRIAN ALAN (NL)
KUIL MAXIM EMILE (NL)
DE SONNEVILLE JAN (NL)
BERTINA ROGIER MARIA (NL)
YUANA YUANA (NL)
OOSTERKAMP TJERK HENDRIK (NL)
ASHCROFT BRIAN ALAN (NL)
KUIL MAXIM EMILE (NL)
DE SONNEVILLE JAN (NL)
Application Number:
PCT/EP2009/009250
Publication Date:
September 10, 2010
Filing Date:
December 23, 2009
Export Citation:
Assignee:
UNIV LEIDEN (NL)
ACADEMISCH ZIEKENHUIS LEIDEN A (NL)
OSANTO SUSANNE (NL)
BERTINA ROGIER MARIA (NL)
YUANA YUANA (NL)
OOSTERKAMP TJERK HENDRIK (NL)
ASHCROFT BRIAN ALAN (NL)
KUIL MAXIM EMILE (NL)
DE SONNEVILLE JAN (NL)
ACADEMISCH ZIEKENHUIS LEIDEN A (NL)
OSANTO SUSANNE (NL)
BERTINA ROGIER MARIA (NL)
YUANA YUANA (NL)
OOSTERKAMP TJERK HENDRIK (NL)
ASHCROFT BRIAN ALAN (NL)
KUIL MAXIM EMILE (NL)
DE SONNEVILLE JAN (NL)
International Classes:
G01N33/554; B01L3/00; G01N30/92; G01N33/543; G01N33/551
Domestic Patent References:
| WO2009100029A1 | 2009-08-13 |
Foreign References:
| US20040033624A1 | 2004-02-19 | |||
| US20050239193A1 | 2005-10-27 | |||
| US20040213443A1 | 2004-10-28 |
Other References:
ENJETI ANOOP K ET AL: "Detection and measurement of microparticles: an evolving research tool for vascular biology", SEMINARS IN THROMBOSIS AND HEMOSTASIS, STUTTGART, DE LNKD- DOI:10.1055/S-2007-1000369, vol. 33, no. 8, 1 November 2007 (2007-11-01), pages 771 - 779, XP009107839, ISSN: 0094-6176
TAYLOR J D ET AL: "Microfluidic fabrication of addressable tethered lipid bilayer arrays and optimization using SPR with silane-derivatized nanoglassy substrates", LAB ON A CHIP - MINIATURISATION FOR CHEMISTRY AND BIOLOGY 2007 GB LNKD- DOI:10.1039/B618940G, vol. 7, no. 7, 2007, pages 927 - 930, XP002576861
CHEN CHIHCHEN ET AL: "Microfluidic isolation and transcriptome analysis of serum microvesicles", LAB ON A CHIP, vol. 10, no. 4, 8 December 2009 (2009-12-08), pages 505 - 511, XP002576862
NAGRATH SUNITHA ET AL: "Isolation of rare circulating tumour cells in cancer patients by microchip technology", NATURE (LONDON), vol. 450, no. 7173, December 2007 (2007-12-01), pages 1235, XP002576863, ISSN: 0028-0836
YUANA Y ET AL: "Atomic force microscopy: A novel approach to the detection of nanosized blood microparticles", JOURNAL OF THROMBOSIS AND HAEMOSTASIS 2010 BLACKWELL PUBLISHING LTD GBR LNKD- DOI:10.1111/J.1538-7836.2009.03654.X, vol. 8, no. 2, 19 October 2009 (2009-10-19), pages 315 - 323, XP002576864
TAYLOR J D ET AL: "Microfluidic fabrication of addressable tethered lipid bilayer arrays and optimization using SPR with silane-derivatized nanoglassy substrates", LAB ON A CHIP - MINIATURISATION FOR CHEMISTRY AND BIOLOGY 2007 GB LNKD- DOI:10.1039/B618940G, vol. 7, no. 7, 2007, pages 927 - 930, XP002576861
CHEN CHIHCHEN ET AL: "Microfluidic isolation and transcriptome analysis of serum microvesicles", LAB ON A CHIP, vol. 10, no. 4, 8 December 2009 (2009-12-08), pages 505 - 511, XP002576862
NAGRATH SUNITHA ET AL: "Isolation of rare circulating tumour cells in cancer patients by microchip technology", NATURE (LONDON), vol. 450, no. 7173, December 2007 (2007-12-01), pages 1235, XP002576863, ISSN: 0028-0836
YUANA Y ET AL: "Atomic force microscopy: A novel approach to the detection of nanosized blood microparticles", JOURNAL OF THROMBOSIS AND HAEMOSTASIS 2010 BLACKWELL PUBLISHING LTD GBR LNKD- DOI:10.1111/J.1538-7836.2009.03654.X, vol. 8, no. 2, 19 October 2009 (2009-10-19), pages 315 - 323, XP002576864
Attorney, Agent or Firm:
CLARK, David (Park View House58 The Ropewalk, Nottingham NG1 5DD, GB)
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