Title:
METHODS FOR INCREASING A CYTOTOXIC T LYMPHOCYTE RESPONSE IN VIVO
Document Type and Number:
WIPO Patent Application WO2001072123
Kind Code:
A9
Abstract:
The invention provides methods for T helper-independent activation of an antigen-specific cytotoxic T lymphocyte response in an individual. The methods generally involve administering to an individual an immunostimulatory nucleic acid molecule in an amount effective to increase an antigen-specific CTL response in the individual. The invention further provides methods for increasing chemokine secretion, which can block HIV infection.
Inventors:
RAZ EYAL (US)
CHO HEARN JAY (US)
RICHMAN DOUGLAS D (US)
HORNER ANTHONY A (US)
CHO HEARN JAY (US)
RICHMAN DOUGLAS D (US)
HORNER ANTHONY A (US)
Application Number:
PCT/US2001/010118
Publication Date:
December 27, 2002
Filing Date:
March 28, 2001
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
US DEPT VETERANS AFFAIRS (US)
RAZ EYAL (US)
CHO HEARN JAY (US)
RICHMAN DOUGLAS D (US)
HORNER ANTHONY A (US)
US DEPT VETERANS AFFAIRS (US)
RAZ EYAL (US)
CHO HEARN JAY (US)
RICHMAN DOUGLAS D (US)
HORNER ANTHONY A (US)
International Classes:
A61K39/00; A61K39/21; A61K39/385; A61K39/39; C12Q1/70; (IPC1-7): A01N43/04; A61K31/70; C07H21/04; C12Q1/68; C12N5/00; C12N15/85
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