METHODS OF INCREASING MATURATION OF HEART, PANCREATIC BETA-CELLS, AND NEURONS - YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD

Title:

METHODS OF INCREASING MATURATION OF HEART, PANCREATIC BETA-CELLS, AND NEURONS

Document Type and Number:

WIPO Patent Application WO/2021/156680

Kind Code:

A3

Abstract:

Provided are methods of generating a metabolically mature human cell selected from the group consisting of a cardiomyocyte, a pancreatic beta cell, and a neuronal cell, using an effective concentration of a conjugated fatty acid and optionally a non- conjugated fatty acid selected from the group consisting of: a monounsaturated omega-9 fatty acid, palmitic acid, linoleic acid (LA) and a short chain fatty acid. Also provided are isolated populations of metabolically mature human cells, and methods and kits using same for selecting a compound for toxicity to the cells.

More Like This:

WO/2012/140132	NUTRITIONAL COMPOSITIONS INCLUDING BRANCHED CHAIN FATTY ACIDS FOR IMPROVING GUT BARRIER FUNCTION
JP5795267	Polynucleotides Encoding Acyl-CoA Synthesizer Homologs and Their Applications
WO/2001/078530	INFANT FORMULAS CONTAINING LONG-CHAIN POLYUNSATURATED FATTY ACIDS AND USES THEREOF

Inventors:

NAHMIAS YAAKOV (IL)
EHRLICH AVNER (IL)
AYYASH MUNEEF (IL)

Application Number:

PCT/IB2021/000106

Publication Date:

September 23, 2021

Filing Date:

February 09, 2021

Export Citation:

Click for automatic bibliography generation Help

Assignee:

YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD (IL)

International Classes:

A61K31/201; C12N5/0735

Foreign References:

US20170266145A1	2017-09-21
US20100254951A1	2010-10-07

Attorney, Agent or Firm:

REINHOLD COHN & PARTNERS et al. (IL)

Download PDF:

View/Download PDF PDF Help

Previous Patent: SYSTEMS AND METHODS FOR MATERNAL UTERINE ACTIVITY DETECTION

Next Patent: MTJ CAPPING LAYER STRUCTURE