Title:
METHODS OF INDUCING CELL DEATH
Document Type and Number:
WIPO Patent Application WO2001003717
Kind Code:
A3
Abstract:
The invention relates to methods of inducing cell death using human Papillomavirus (HPV) E2 or E7 proteins.
Inventors:
GASTON KEVIN LEON (GB)
STERN PETER LESLEY (GB)
CLARKE ANTHONY RUSSELL (GB)
STERN PETER LESLEY (GB)
CLARKE ANTHONY RUSSELL (GB)
Application Number:
PCT/GB2000/002693
Publication Date:
November 15, 2001
Filing Date:
July 13, 2000
Export Citation:
Assignee:
UNIV BRISTOL (GB)
GASTON KEVIN LEON (GB)
STERN PETER LESLEY (GB)
CLARKE ANTHONY RUSSELL (GB)
GASTON KEVIN LEON (GB)
STERN PETER LESLEY (GB)
CLARKE ANTHONY RUSSELL (GB)
International Classes:
C12N15/09; A61K38/00; A61K39/21; A61K48/00; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P35/02; A61P43/00; C07K14/025; A61K39/00; (IPC1-7): C12N15/37; C12N15/62; C07K14/025; A61K31/70; A61K38/16
Domestic Patent References:
| WO1998032861A1 | 1998-07-30 | |||
| WO1998001148A1 | 1998-01-15 | |||
| WO1995004151A2 | 1995-02-09 |
Foreign References:
| EP0523395A2 | 1993-01-20 |
Other References:
WEBSTER K. ET AL.: "The induction of apoptotic cell death by the HPV E2 protein.", BIOCHEM. SOC. TRANSACT., vol. 27, 7 April 1999 (1999-04-07) - 9 April 1999 (1999-04-09), pages A97, XP002154454
FRATTINI M.G. ET AL.: "Abrogation of a mitotic checkpoint by E2 proteins from oncogenic human papillomaviruses correlates with increased turnover of the p53 tumor suppressor protein.", EMBO J., vol. 16, no. 2, 1997, pages 318 - 331, XP002154455
STÖPPLER H. ET AL.: "The E7 protein of human papillomavirus type 16 sensitizes primary human keratinocytes to apoptosis", ONCOGENE, vol. 17, 10 September 1998 (1998-09-10), pages 1207 - 1214, XP000971041
NAKAMURA T. ET AL.: "A human papillomavirus type 18 E6/E7 transgene sensitizes mouse lens cells to human wild-typep53-mediated apoptosis.", ONCOGENE, vol. 14, 1997, pages 2991 - 2998, XP000971042
HICKMAN E. ET AL.: "Perturbation of the p53 response by human papillomavirus type 16 E7", J. VIROL., vol. 71, no. 5, May 1997 (1997-05-01), pages 3710 - 3718, XP000961204
JONES D.L. ET AL.: "Destabilization of the Rb tumor suppressor protein and stabilization of p53 contribute to HPV type 16-induced apoptosis.", VIROLOGY, vol. 239, 1997, pages 97 - 107, XP000961206
WEBSTER K. ET AL.: "The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.", J. BIOL. CHEM., vol. 275, no. 1, 7 January 2000 (2000-01-07), pages 87 - 94, XP002154456
FRATTINI M.G. ET AL.: "Abrogation of a mitotic checkpoint by E2 proteins from oncogenic human papillomaviruses correlates with increased turnover of the p53 tumor suppressor protein.", EMBO J., vol. 16, no. 2, 1997, pages 318 - 331, XP002154455
STÖPPLER H. ET AL.: "The E7 protein of human papillomavirus type 16 sensitizes primary human keratinocytes to apoptosis", ONCOGENE, vol. 17, 10 September 1998 (1998-09-10), pages 1207 - 1214, XP000971041
NAKAMURA T. ET AL.: "A human papillomavirus type 18 E6/E7 transgene sensitizes mouse lens cells to human wild-typep53-mediated apoptosis.", ONCOGENE, vol. 14, 1997, pages 2991 - 2998, XP000971042
HICKMAN E. ET AL.: "Perturbation of the p53 response by human papillomavirus type 16 E7", J. VIROL., vol. 71, no. 5, May 1997 (1997-05-01), pages 3710 - 3718, XP000961204
JONES D.L. ET AL.: "Destabilization of the Rb tumor suppressor protein and stabilization of p53 contribute to HPV type 16-induced apoptosis.", VIROLOGY, vol. 239, 1997, pages 97 - 107, XP000961206
WEBSTER K. ET AL.: "The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.", J. BIOL. CHEM., vol. 275, no. 1, 7 January 2000 (2000-01-07), pages 87 - 94, XP002154456
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