Title:
METHODS FOR LIGAND DISCOVERY
Document Type and Number:
WIPO Patent Application WO2003046200
Kind Code:
A3
Abstract:
The present invention provides novel methods for ligand discovery. The inventive methods rely on a process termed "tethering" where potential ligands are covalently bonded or "tethered" to a target and subsequently identified as exemplified by the figure.
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Inventors:
ERLANSON DANIEL A (US)
BRAISTED ANDREW A (US)
WELLS JAMES (US)
BRAISTED ANDREW A (US)
WELLS JAMES (US)
Application Number:
PCT/US2002/013061
Publication Date:
July 24, 2003
Filing Date:
April 24, 2002
Export Citation:
Assignee:
SUNESIS PHARMACEUTICALS INC (US)
ERLANSON DANIEL A (US)
BRAISTED ANDREW A (US)
WELLS JAMES (US)
ERLANSON DANIEL A (US)
BRAISTED ANDREW A (US)
WELLS JAMES (US)
International Classes:
C07C323/39; C07C335/04; G01N33/531; C07D207/46; C07D333/38; C07D333/70; C07D401/04; C07D405/12; C07K14/00; C07K14/435; C12Q1/00; C12Q1/68; C12Q1/70; C40B20/08; C40B30/04; C40B40/04; G01N33/00; G01N33/53; C07B61/00; (IPC1-7): C12Q1/00; C12Q1/70; G01N33/53
Foreign References:
| US5367058A | 1994-11-22 |
Other References:
MARCHAND-BRYNAERT ET AL.: "Design and synthesis of a bifunctional label for selection of B-lactamase displayed on filamentous bacteriophage by catalytic activity", TETRAHEDRON, vol. 52, no. 15, 1996, pages 5591 - 5606, XP004104212
ERLANSON ET AL.: "Site-directed ligand discovery", PROC. NATL. ACAD. SCI. USA, vol. 97, no. 17, August 2000 (2000-08-01), pages 9367 - 9372, XP002199107
ERLANSON ET AL.: "Site-directed ligand discovery", PROC. NATL. ACAD. SCI. USA, vol. 97, no. 17, August 2000 (2000-08-01), pages 9367 - 9372, XP002199107
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