Title:
METHODS OF MAKING PORPHYRINS AND RELATED COMPOUNDS WITH LEWIS ACID
Document Type and Number:
WIPO Patent Application WO2003027066
Kind Code:
A3
Abstract:
The present invention provides methods of making porphyrins and related compounds such as chlorins by condensing suitable starting materials (e.g., a dipyrromethane-dicarbinol plus dipyrromethane) in a polar solvent in the presence of a Lewis acid. The reactions are preferably carried out in a manner that minimizes rearrangement of the reaction product.
Inventors:
LINDSEY JONATHAN S (US)
GEIER G RICHARD III (US)
YU LIANHE (US)
GEIER G RICHARD III (US)
YU LIANHE (US)
Application Number:
PCT/US2002/029783
Publication Date:
August 28, 2003
Filing Date:
September 19, 2002
Export Citation:
Assignee:
UNIV NORTH CAROLINA STATE (US)
LINDSEY JONATHAN S (US)
GEIER G RICHARD III (US)
YU LIANHE (US)
LINDSEY JONATHAN S (US)
GEIER G RICHARD III (US)
YU LIANHE (US)
International Classes:
C07D487/22; (IPC1-7): C07D487/22
Domestic Patent References:
| WO2002092601A1 | 2002-11-21 |
Foreign References:
| US5241062A | 1993-08-31 | |||
| EP0780391A2 | 1997-06-25 |
Other References:
LEE C.-H. ET AL.: "Synthetic approaches to regioisommerically pure porphyrins bearing four different meso-substituents", TETRAHEDRON, vol. 51, no. 43, 1995, pages 11645 - 11672, XP002965500
GRYKO D. ET AL.: "Rational synthesis of meso-substituted porphyrins bearing one nitrogen heterocyclic group", J. ORG. CHEM., vol. 65, no. 7, 2000, pages 2249 - 2252, XP002965901
WALLECE D.M. ET AL.: "Stepwise synthesis of unsymmetrical tetra-arylporphyrins. Adaptation of the MacDonald dipyrrole self-condensation methodology", TET. LET., vol. 31, no. 50, 1990, pages 7265 - 7268, XP002965945
TANIGUCHI S. ET AL.: "A facile route to tripyrrane from 2,5-bis(hydroxymethyl)pyrrole and the improved synthesis of porphine by the "3+1" approach", SYNLETT., no. 1, 1999, pages 73 - 74, XP002965902
GRYKO D. ET AL.: "Rational synthesis of meso-substituted porphyrins bearing one nitrogen heterocyclic group", J. ORG. CHEM., vol. 65, no. 7, 2000, pages 2249 - 2252, XP002965901
WALLECE D.M. ET AL.: "Stepwise synthesis of unsymmetrical tetra-arylporphyrins. Adaptation of the MacDonald dipyrrole self-condensation methodology", TET. LET., vol. 31, no. 50, 1990, pages 7265 - 7268, XP002965945
TANIGUCHI S. ET AL.: "A facile route to tripyrrane from 2,5-bis(hydroxymethyl)pyrrole and the improved synthesis of porphine by the "3+1" approach", SYNLETT., no. 1, 1999, pages 73 - 74, XP002965902
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