Title:
METHODS AND MATERIALS FOR IDENTIFYING AND TREATING VACCINE-INDUCED IMMUNE THROMBOTIC THROMBOCYTOPENIA
Document Type and Number:
WIPO Patent Application WO/2023/150457
Kind Code:
A8
Abstract:
Methods and materials for identifying and/or treating mammals (e.g., humans) as having vaccine-induced immune thrombotic thrombocytopenia (V1TT) are provided herein. In some cases, the methods and materials provided herein can be used to differentiate between VITT and spontaneous heparin-induced thrombocytopenia (s-HIT). Specifically, the method comprising contacting the sample from a mammal that (i) has thrombocytopenia, and/or thrombosis, and (ii) does not have heparin-induced thrombocytopenia (HIT) with an uncomplexed platelet factor 4 (PF4) polypeptide for detection.
Inventors:
PADMANABHAN ANAND (US)
Application Number:
PCT/US2023/061341
Publication Date:
February 08, 2024
Filing Date:
January 26, 2023
Export Citation:
Assignee:
MAYO FOUND MEDICAL EDUCATION & RES (US)
International Classes:
A61K39/395; A01N63/00; A61K38/36; A61P7/02; G01N33/00; G01N33/53; C12Q1/70
Attorney, Agent or Firm:
KAYTOR, Elizabeth N. et al. (US)
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