Title:
METHODS OF MEASURING THE ABILITY OF A TEST COMPOUND TO INACTIVATE A BIOLOGICAL TARGET IN CELLS OF A SUBJECT
Document Type and Number:
WIPO Patent Application WO2004092728
Kind Code:
A3
Abstract:
The present invention provides a method of assessing the ability of a compound (the "test compound") which is an inhibitor of a biological target to inhibit the biological target in a biological compartment of interest when administered to a subject in vivo.
Inventors:
BENJAMIN DENNIS (US)
THOMPSON CHARLES (US)
WANG BRYAN (US)
WAKEFIELD JAMES (US)
GEFTER MALCOLM L (US)
ARICO-MUENDEL CHRISTOPHER C (US)
THOMPSON CHARLES (US)
WANG BRYAN (US)
WAKEFIELD JAMES (US)
GEFTER MALCOLM L (US)
ARICO-MUENDEL CHRISTOPHER C (US)
Application Number:
PCT/US2004/010941
Publication Date:
June 02, 2005
Filing Date:
April 07, 2004
Export Citation:
Assignee:
PRAECIS PHARM INC (US)
BENJAMIN DENNIS (US)
THOMPSON CHARLES (US)
WANG BRYAN (US)
WAKEFIELD JAMES (US)
GEFTER MALCOLM L (US)
ARICO-MUENDEL CHRISTOPHER C (US)
BENJAMIN DENNIS (US)
THOMPSON CHARLES (US)
WANG BRYAN (US)
WAKEFIELD JAMES (US)
GEFTER MALCOLM L (US)
ARICO-MUENDEL CHRISTOPHER C (US)
International Classes:
C12Q1/37; G01N33/50; G01N33/53; G01N33/567; G01N33/573; G01N33/574; (IPC1-7): G01N33/573; C12Q1/37
Domestic Patent References:
| WO2002065977A2 | 2002-08-29 |
Other References:
MORAIN P ET AL: "Pharmacodynamic and pharmacokinetic profile of S 17092, a new orally active prolyl endopeptidase inhibitor, in elderly healthy volunteers. A phase I study", BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, BLACKWELL SCIENTIFIC PUBL, GB, vol. 50, no. 4, October 2000 (2000-10-01), pages 350 - 359, XP002246424, ISSN: 0306-5251
PATENT ABSTRACTS OF JAPAN vol. 018, no. 523 (C - 1256) 4 October 1994 (1994-10-04)
SIN NY ET AL: "The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 94, no. 12, 1997, pages 6099 - 6103, XP002323759, ISSN: 0027-8424
PATENT ABSTRACTS OF JAPAN vol. 018, no. 523 (C - 1256) 4 October 1994 (1994-10-04)
SIN NY ET AL: "The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 94, no. 12, 1997, pages 6099 - 6103, XP002323759, ISSN: 0027-8424
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