Title:
METHODS OF MODULATING PHARMACOKINETICS OF OLIGONUCLEOTIDES
Document Type and Number:
WIPO Patent Application WO2003004603
Kind Code:
A3
Abstract:
2'-O-(2-Methylthioethyl), has been incorporated into oligonucleotides and evaluated for antisense properties in comparison with the known 2'-O-(2-methoxyethyl)2'-O-MOE modification. The 2'-O-MOE modified oligonucleotides exhibit improved binding to human serum albumin compared with the 2'-O-MOE modified oligonucleotides and maintain high binding affinity to target RNA.
Inventors:
PRAKASH THAZHA P (US)
MANOHARAN MUTHIAH (US)
MANOHARAN MUTHIAH (US)
Application Number:
PCT/US2002/020940
Publication Date:
December 04, 2003
Filing Date:
July 01, 2002
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
PRAKASH THAZHA P (US)
MANOHARAN MUTHIAH (US)
PRAKASH THAZHA P (US)
MANOHARAN MUTHIAH (US)
International Classes:
C07H19/06; C12N15/113; (IPC1-7): C12Q1/68; C12P19/34
Foreign References:
| US6147200A | 2000-11-14 | |||
| US6239272B1 | 2001-05-29 |
Other References:
PRAKASH T. ET AL.: "2'-O-(2-(methylthio)ethyl)-modified oligonucleotide: An analogue of 2'-O-(2-(methoxy)ethyl)-modified oligonucleotide with improved protein binding properties and high binding affinity to target RNA", BIOCHEMISTRY, vol. 41, September 2002 (2002-09-01), pages 11642 - 11648, XP002962878
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