Title:
METHODS AND PHARMACEUTICAL COMPOSITIONS FOR HEALING WOUNDS
Document Type and Number:
WIPO Patent Application WO2002009639
Kind Code:
A3
Abstract:
A pharmaceutical composition and method for inducing or accelerating a healing process of a skin wound are described. The pharmaceutical composition contains, as an active ingredient, a therapeutically effective amount of an agent for either enhancing PKC production and/or enhancing PKC activation; and a pharmaceutically acceptable carrier. The method is effected by administering the composition to a wound.
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Inventors:
TENNENBAUM TAMAR (IL)
SAMPSON SANFORD (IL)
KUROKI TOSHIO (JP)
ALT ADDY (IL)
SHEN SHLOMZION (IL)
SAMPSON SANFORD (IL)
KUROKI TOSHIO (JP)
ALT ADDY (IL)
SHEN SHLOMZION (IL)
Application Number:
PCT/IL2001/000675
Publication Date:
November 06, 2003
Filing Date:
July 23, 2001
Export Citation:
Assignee:
UNIV BAR ILAN (IL)
TENNENBAUM TAMAR (IL)
SAMPSON SANFORD (IL)
KUROKI TOSHIO (JP)
ALT ADDY (IL)
SHEN SHLOMZION (IL)
TENNENBAUM TAMAR (IL)
SAMPSON SANFORD (IL)
KUROKI TOSHIO (JP)
ALT ADDY (IL)
SHEN SHLOMZION (IL)
International Classes:
C12N15/09; A61K35/36; A61K38/28; A61K38/45; A61K45/00; A61K48/00; A61P3/10; A61P17/02; A61P43/00; C12N5/071; C12N5/10; C12N9/12; C12N15/54; A61K35/12; (IPC1-7): A61K48/00; A61K35/00
Foreign References:
| US5145679A | 1992-09-08 |
Other References:
HENGGE U. ET AL: "Epidermis as target for in vivo gene therapy", J. INVEST. DERMATOL., vol. 105, no. 3, September 1995 (1995-09-01), pages 448, XP002976004
SETOGUCHI ET AL: "Ex vivo and in vivo gene transfer to the skin using replication-deficient recombinant adenovirus vectors", J. INVEST. DERMATOL., vol. 102, no. 4, April 1994 (1994-04-01), pages 415 - 421, XP002044071
FERBER ET AL: "Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozoticin-induced hyperglycemia", NATURE MEDICINE, vol. 6, no. 5, May 2000 (2000-05-01), pages 568 - 572, XP002154420
MACFARLANE ET AL: "Glucose stimulates translocation of the homeodomain of transcription factor PDX1 from the cytoplasm to the nucleus of pancreatic bet-cells", J. BIOL. CHEM., vol. 274, no. 2, 8 January 1999 (1999-01-08), pages 1011 - 1016, XP002144478
OHBA ET AL: "Induction of differentiation in normal human kerotinocytes by adenovirus mediated introduction of the neu and sigma isoforms of protein kinase C", MOL. AND CELL. BIOL., vol. 18, no. 9, September 1998 (1998-09-01), pages 5199 - 5207, XP002223024
SETOGUCHI ET AL: "Ex vivo and in vivo gene transfer to the skin using replication-deficient recombinant adenovirus vectors", J. INVEST. DERMATOL., vol. 102, no. 4, April 1994 (1994-04-01), pages 415 - 421, XP002044071
FERBER ET AL: "Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozoticin-induced hyperglycemia", NATURE MEDICINE, vol. 6, no. 5, May 2000 (2000-05-01), pages 568 - 572, XP002154420
MACFARLANE ET AL: "Glucose stimulates translocation of the homeodomain of transcription factor PDX1 from the cytoplasm to the nucleus of pancreatic bet-cells", J. BIOL. CHEM., vol. 274, no. 2, 8 January 1999 (1999-01-08), pages 1011 - 1016, XP002144478
OHBA ET AL: "Induction of differentiation in normal human kerotinocytes by adenovirus mediated introduction of the neu and sigma isoforms of protein kinase C", MOL. AND CELL. BIOL., vol. 18, no. 9, September 1998 (1998-09-01), pages 5199 - 5207, XP002223024
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