Title:
METHODS FOR PREPARING (S)-4-CHLORO-2-AMINOBUTYRIC ACID HYDROCHLORIDE AND (S)-4-CHLORO-2-AMINOBUTYRATE
Document Type and Number:
WIPO Patent Application WO/2023/051768
Kind Code:
A1
Abstract:
Provided is a method for preparing (S)-4-chloro-2-aminobutyric acid hydrochloride, the method comprising the following step: subjecting L-homoserine lactone hydrochloride of formula (I) and hydrogen chloride to a ring-opening chlorination reaction to generate (S)-4-chloro-2-aminobutyric acid hydrochloride of formula (II). Further provided is a method for preparing (S)-4-chloro-2-aminobutyrate.
Inventors:
ZHOU LEI (CN)
ZENG WEI (CN)
LIU YONGJIANG (CN)
CHENG KE (CN)
ZENG WEI (CN)
LIU YONGJIANG (CN)
CHENG KE (CN)
Application Number:
PCT/CN2022/123151
Publication Date:
April 06, 2023
Filing Date:
September 30, 2022
Export Citation:
Assignee:
LIER CHEMICAL CO LTD (CN)
International Classes:
C07C229/20; C07C227/18
Foreign References:
| US4590292A | 1986-05-20 | |||
| CN109265336A | 2019-01-25 | |||
| US5442088A | 1995-08-15 | |||
| CN109369432A | 2019-02-22 | |||
| CN110845347A | 2020-02-28 |
Other References:
KOCH T., BUCHARDT O.: "SYNTHESIS OF L-(+)-SELENOMETHIONINE.", SYNTHESIS, GEORG THIEME VERLAG, STUTTGART, DE., no. 11., 1 November 1993 (1993-11-01), STUTTGART, DE. , pages 1065 - 1067., XP000404250, ISSN: 0039-7881, DOI: 10.1055/s-1993-25996
何伟彪 等 (HE, WEIBIAO ET AL.): "L-4-溴-2-氨基丁酸的“两锅法”合成 (Synthesis of L-2-Amino-4-bromobutanoic Acid)", 化学试剂 (CHEMICAL REAGENTS), vol. 30, no. 2, 31 December 2008 (2008-12-31), pages 117 - 119
何伟彪 等 (HE, WEIBIAO ET AL.): "L-4-溴-2-氨基丁酸的“两锅法”合成 (Synthesis of L-2-Amino-4-bromobutanoic Acid)", 化学试剂 (CHEMICAL REAGENTS), vol. 30, no. 2, 31 December 2008 (2008-12-31), pages 117 - 119
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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