Title:
METHODS OF PROCESSING EXTRACTS OF A T. WILFORDII HOOK F. PLANT
Document Type and Number:
WIPO Patent Application WO/2012/118942
Kind Code:
A3
Abstract:
Products derived from the Tripterygium wilfordii Hook F (TwHF) plant in the form of extracts are provided that are useful in preventing, treating, or ameliorating a symptom of an inflammatory disorder or an immune disorder, such as an auto-immune disease. Also provided are methods of freeze-drying a TwHF root and/or root portion, methods of debarking a freeze-dried TwHF root and/or root portion, methods of preparing and/or refining extracts in freely flowable solid form from freeze-dried debarked TwHF roots and/or root portions, and methods of using freely flowable solid extracts of TwHF in preventing, treating or ameliorating a symptom of an inflammatory disorder and/or an immune disorder.
Inventors:
PAFFENDORF GEORGE (US)
CIMARUSTI CHRISTOPHER (US)
CIMARUSTI CHRISTOPHER (US)
Application Number:
PCT/US2012/027231
Publication Date:
March 13, 2014
Filing Date:
March 01, 2012
Export Citation:
Assignee:
PHYTOMEDICS CORP INC (BS)
PAFFENDORF GEORGE (US)
CIMARUSTI CHRISTOPHER (US)
PAFFENDORF GEORGE (US)
CIMARUSTI CHRISTOPHER (US)
International Classes:
A61K36/18; A23L19/00
Foreign References:
| US20040018260A1 | 2004-01-29 | |||
| US20100104675A1 | 2010-04-29 | |||
| US20090263516A1 | 2009-10-22 |
Other References:
SYLVESTER ET AL.: "Tripterygium wilfordii Hook F Extract Suppresses Proinflammatory Cytokine -Induced Expression of Matrix Metalloproteinase Genes in Articular Chondrocytes by Inhibiting Activating Protein-1 and Nuclear Factor-kB Activities", MOL PHARMACOL, vol. 59, 2001, pages 1196 - 1205, XP055136890
Attorney, Agent or Firm:
BRASHEAR, Jeanne, M. et al. (Gerstein & Borun LLP233 S. Wacker Driv, Chicago IL, US)
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