METHODS FOR PRODUCING CHIRAL CHROMONES, CHROMANES, AMINO SUBSTITUTED CHROMANES AND INTERMEDIATES THEREFOR

Title:

METHODS FOR PRODUCING CHIRAL CHROMONES, CHROMANES, AMINO SUBSTITUTED CHROMANES AND INTERMEDIATES THEREFOR

Document Type and Number:

WIPO Patent Application WO2001094335

Kind Code:

A3

Abstract:

Disclosed are process steps and novel processes for producing chromane compositions enriched in at least one (2R or 2S) enantiomer, preferably chroman-2-yl carboxylic acid compounds and chroman-2-yl carboxylic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are enzymatic processes for resolving chiral intermediates or final products to provide desired enantiomers.

Inventors:

BRIGGS BARBARA (US)
HANSEN MARVIN (US)
KANTER JAMES (US)
MULLINS JOHN J G (US)
RUHTER GERD (DE)
UDODONG UKO (US)
VERRAL DANIEL II (US)
ZMIJEWSKI MILTON JR (US)

Application Number:

PCT/US2001/017980

Publication Date:

August 08, 2002

Filing Date:

June 01, 2001

Export Citation:

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Assignee:

LILLY CO ELI (US)
COR THERAPEUTICS INC (US)
BRIGGS BARBARA (US)
HANSEN MARVIN (US)
KANTER JAMES (US)
MULLINS JOHN J G (US)
RUHTER GERD (DE)
UDODONG UKO (US)
VERRAL DANIEL II (US)
ZMIJEWSKI MILTON JR (US)

International Classes:

A61K31/353; A61P7/02; C07D311/22; C07D311/24; C07D311/58; C07D311/74; (IPC1-7): C07D311/58; C07D311/22; C07D311/24; C07D311/70; A61K31/353; A61P7/02

Foreign References:

US4026907A	1977-05-31
US5731324A	1998-03-24

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