METHODS FOR PRODUCING AND IMPROVING THERAPEUTIC POTENCY OF BINDING POLYPEPTIDES

WIPO Patent Application WO2002036615

A3

The invention provides a binding polypeptide, or functional fragment thereof, comprising a kon of at least about 9 x 10<7> M<-1> s<-1> for associating with a ligand and having therapeutic potency. The invention also provides a method of determining the therapeutic potency of a binding polypeptide. The methods consist of (a) contacting a binding polypeptide with a ligand; (b) measuring association rate for binding between the binding polypeptide and the ligand, and (c) comparing the association rate for the binding polypeptide to an association rate for a therapeutic control, the relative association rate for the binding polypeptide compared to the association rate for the therapeutic control indicating that the binding polypeptide wil exhibit a difference in therapeutic potency correlative with the difference between the association rates.

HUSE WILLIAM D (US)

PCT/US2001/046248

August 21, 2003

October 30, 2001

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APPLIED MOLECULAR EVOLUTION (US)
HUSE WILLIAM D (US)

A61K38/00; A61K38/22; A61K38/28; A61K38/43; A61K38/44; A61K38/45; A61K38/46; A61K39/395; C07K1/00; C07K14/00; C07K16/00; C12N9/18; G01N33/557; (IPC1-7): C07K14/00; A61K38/00; C07K16/00; C12N9/18; G01N33/68

US5474911A

1995-12-12

ELG MARGARETA ET AL: "The importance of enzyme inhibition kinetics for the effect of thrombin inhibitors in a rat model of arterial thrombosis.", THROMBOSIS AND HAEMOSTASIS, vol. 78, no. 4, 1997, pages 1286 - 1292, XP009004940, ISSN: 0340-6245
HOPKINS PAUL C R ET AL: "Development of a Novel Recombinant Serpin with Potential Antithrombotic Properties.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 20, 1995, pages 11866 - 11871, XP002229287, ISSN: 0021-9258

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