Title:
METHODS FOR THE PRODUCTION OF UNSATURATED FATTY ACIDS
Document Type and Number:
WIPO Patent Application WO2003074716
Kind Code:
A3
Abstract:
The invention relates to methods for the production of unsaturated fatty acids, preferably conjugated multiple-unsaturated fatty acids such as conjugated linoleic acid (CLA) by transgenic expression of desaturases from insects of the Lepidoptera order. The invention also relates to transgenic expression cassettes for transgenic expression of desaturases from insects of the Lepidoptera order, and to transgenic organisms transformed therewith.
Inventors:
RENZ ANDREAS (DE)
GIPMANS MARTIJN (DE)
FEUSSNER IVO (DE)
GIPMANS MARTIJN (DE)
FEUSSNER IVO (DE)
Application Number:
PCT/EP2003/002011
Publication Date:
December 24, 2003
Filing Date:
February 27, 2003
Export Citation:
Assignee:
BASF PLANT SCIENCE GMBH (DE)
RENZ ANDREAS (DE)
GIPMANS MARTIJN (DE)
FEUSSNER IVO (DE)
RENZ ANDREAS (DE)
GIPMANS MARTIJN (DE)
FEUSSNER IVO (DE)
International Classes:
C12N9/02; C12N15/53; C12N15/82; C12P7/64; (IPC1-7): C12P7/40; A23D7/00; A23D9/00; A61K7/00; C07C69/58
Domestic Patent References:
| WO2001000846A2 | 2001-01-04 | |||
| WO1999047135A1 | 1999-09-23 | |||
| WO1997018320A1 | 1997-05-22 |
Other References:
LIU WEITIAN ET AL: "Gene characterized for membrane desaturase that produces (E)-11 isomers of mono- and diunsaturated fatty acids.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 99, no. 2, 22 January 2002 (2002-01-22), http://www.pnas.org January 22, 2002, pages 620 - 624, XP002252845, ISSN: 0027-8424
CAHOON EDGAR B ET AL: "Formation of conjugated DELTA8,DELTA10-double bonds by DELTA12-oleic-acid desaturase-related enzymes. Biosynthetic origin of calendic acid.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 4, 26 January 2001 (2001-01-26), pages 2637 - 2643, XP002252846, ISSN: 0021-9258
CAHOON EDGAR B ET AL: "Production of fatty acid components of meadowfoam oil in somatic soybean embryos.", PLANT PHYSIOLOGY (ROCKVILLE), vol. 124, no. 1, September 2000 (2000-09-01), pages 243 - 251, XP002252847, ISSN: 0032-0889
QIU XIAO ET AL: "Identification and analysis of a gene from Calendula officinalis encoding a fatty acid conjugase.", PLANT PHYSIOLOGY (ROCKVILLE), vol. 125, no. 2, February 2001 (2001-02-01), pages 847 - 855, XP002252848, ISSN: 0032-0889
FRITSCHE KATHRIN ET AL: "Isolation and characterization of a calendic acid producing (8,11)-linoleoyl desaturase.", FEBS LETTERS, vol. 462, no. 3, 3 December 1999 (1999-12-03), pages 249 - 253, XP002252849, ISSN: 0014-5793
KNIPPLE DOUGLAS C ET AL: "Cloning and functional expression of a cDNA encoding a pheromone gland-specific acyl-CoA DELTA11-desaturase of the cabbage looper moth, Trichoplusia ni.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 26, 22 December 1998 (1998-12-22), Dec. 22, 1998, pages 15287 - 15292, XP002252850, ISSN: 0027-8424
CAHOON EDGAR B ET AL: "Formation of conjugated DELTA8,DELTA10-double bonds by DELTA12-oleic-acid desaturase-related enzymes. Biosynthetic origin of calendic acid.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 4, 26 January 2001 (2001-01-26), pages 2637 - 2643, XP002252846, ISSN: 0021-9258
CAHOON EDGAR B ET AL: "Production of fatty acid components of meadowfoam oil in somatic soybean embryos.", PLANT PHYSIOLOGY (ROCKVILLE), vol. 124, no. 1, September 2000 (2000-09-01), pages 243 - 251, XP002252847, ISSN: 0032-0889
QIU XIAO ET AL: "Identification and analysis of a gene from Calendula officinalis encoding a fatty acid conjugase.", PLANT PHYSIOLOGY (ROCKVILLE), vol. 125, no. 2, February 2001 (2001-02-01), pages 847 - 855, XP002252848, ISSN: 0032-0889
FRITSCHE KATHRIN ET AL: "Isolation and characterization of a calendic acid producing (8,11)-linoleoyl desaturase.", FEBS LETTERS, vol. 462, no. 3, 3 December 1999 (1999-12-03), pages 249 - 253, XP002252849, ISSN: 0014-5793
KNIPPLE DOUGLAS C ET AL: "Cloning and functional expression of a cDNA encoding a pheromone gland-specific acyl-CoA DELTA11-desaturase of the cabbage looper moth, Trichoplusia ni.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 26, 22 December 1998 (1998-12-22), Dec. 22, 1998, pages 15287 - 15292, XP002252850, ISSN: 0027-8424
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