Title:
METHODS OF PROMOTING HEALING OF CARTILAGE DEFECTS AND METHOD OF CAUSING STEM CELLS TO DIFFERENTIATE BY THE ARTICULAR CHONDROCYTE PATHWAY
Document Type and Number:
WIPO Patent Application WO2006050213
Kind Code:
A3
Abstract:
Methods of promoting healing of a cartilage defect in a region of cartilage, which comprises the defect and which may further comprise stem cells, and methods of promoting healing of a cartilage defect in a region of cartilage, which comprises the defect and an implant comprising cartilage scaffold or a cartilage graft, which methods comprise contacting the region with various combinations of cartilage fragments, a growth factor, a partially synthesized extracellular matrix, a scaffold, an implant comprising cartilage scaffold, an implant comprising a cartilage graft, stem cells, chondrocytes, a proteoglycan, an anti-oxidant, a collagen precursor, a vitamin, a mineral, and/or a cartilage-degrading enzyme; and a method of causing stem cells to differentiate by the articular chondrocyte pathway comprising contacting the stem cells with a compound comprising an active alcohol moiety.
Inventors:
MICHALOW ALEXANDER E (US)
Application Number:
PCT/US2005/039166
Publication Date:
August 24, 2006
Filing Date:
October 27, 2005
Export Citation:
Assignee:
MICHALOW ALEXANDER E (US)
International Classes:
A61K35/32; A61K35/39; C12N5/077
Foreign References:
| US6355239B1 | 2002-03-12 | |||
| EP1410811A1 | 2004-04-21 |
Other References:
ALBRECHT F ET AL: "Closure of osteochondral lesions using chrondral fragments and fibrin adhesive", ARCHIVES OF ORTHOPAEDIC AND TRAUMATIC SURGERY 1983 GERMANY, vol. 101, no. 3, 1983, pages 213 - 217, XP008061695
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