Title:
METHODS FOR RECOVERING CLEAVED PEPTIDE FROM A SUPPORT
Document Type and Number:
WIPO Patent Application WO2005063792
Kind Code:
A3
Abstract:
Methods for the solid phase synthesis of peptides and peptide intermediates, in particular methods involving recovering peptides from resin supports at excellent yield. In this invention, an alternating at least partially repeating cycle of shrinking and swelling treatments are used. Each shrinking or swelling part of a cycle may involve one or more washes. The process provides excellent recovery of peptide in a very efficient manner in terms of the number of individual washes and the total volume of wash reagents used.
Inventors:
BIGELOW ROGER D (US)
CAIN ROBERT O (US)
CAIN ROBERT O (US)
Application Number:
PCT/EP2004/014601
Publication Date:
November 03, 2005
Filing Date:
December 22, 2004
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
BIGELOW ROGER D (US)
CAIN ROBERT O (US)
BIGELOW ROGER D (US)
CAIN ROBERT O (US)
International Classes:
C07K1/04; C07K14/16; (IPC1-7): C07K1/04
Domestic Patent References:
| WO2003029233A1 | 2003-04-10 | |||
| WO2004027045A2 | 2004-04-01 |
Foreign References:
| US4218439A | 1980-08-19 | |||
| US4594329A | 1986-06-10 | |||
| US6022955A | 2000-02-08 |
Other References:
BRAY B L: "LARGE-SCALE MANUFACTURE OF PEPTIDE THERAPEUTICS BY CHEMICAL SYNTHESIS", NATURE REVIEWS. DRUG DISCOVERY, NATURE PUBLISHING GROUP, BASINGSTOKE, GB, vol. 2, no. 7, July 2003 (2003-07-01), pages 587 - 593, XP009046605, ISSN: 1474-1784
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