Title:
METHODS OF REGULATING ADENO-ASSOCIATED VIRUS PRODUCTION
Document Type and Number:
WIPO Patent Application WO/2022/261475
Kind Code:
A8
Abstract:
The presently disclosed subject matter relates to compositions and methods for regulating recombinant adeno-associated virus (rAAV) production in cell culture. In particular, the presently disclosed subject matter relates to strategies to overcome AAV Rep protein-mediated cytotoxicity by reversible post-translational regulation of the expression of AAV Rep and helper proteins, resulting in regulated rAAV production.
Inventors:
YAZICIOGLU MUSTAFA (US)
OZDEMIR AHMET (US)
OZDEMIR AHMET (US)
Application Number:
PCT/US2022/033071
Publication Date:
December 28, 2023
Filing Date:
June 10, 2022
Export Citation:
Assignee:
SPARK THERAPEUTICS INC (US)
International Classes:
A61K38/44; A61K38/16; A61K38/52; C12N7/02; C12N7/04; C12N9/02; C12N9/90; C12N15/864
Attorney, Agent or Firm:
LENDARIS, Steven, P. (US)
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