Title:
METHODS FOR RESTORING AND/OR ENHANCING ACCOMMODATION IN PSEUDO PHAKIA
Document Type and Number:
WIPO Patent Application WO2000044379
Kind Code:
A3
Abstract:
A method for increasing the amount of accommodation in an eye of a mammal which eye includes an artificial intraocular lens. The method provides for administering to the mammal the amount of a muscarinic agent necessary to restore tonic accommodation.
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Inventors:
GWON ARLENE
WOLDE MUSSIE ELIZABETH
WOLDE MUSSIE ELIZABETH
Application Number:
PCT/US2000/001911
Publication Date:
November 30, 2000
Filing Date:
January 25, 2000
Export Citation:
Assignee:
ALLERGAN SALES INC (US)
International Classes:
C07D295/08; A61K31/221; A61K31/27; A61K31/341; A61K31/4178; A61K31/4453; A61K31/551; A61K31/5513; A61K45/00; A61P27/02; A61P27/10; C07D307/20; C07D405/06; C07D471/04; (IPC1-7): A61K31/4178; A61K31/27; A61K31/341; A61K31/5513; A61P27/10
Other References:
TOKORO, TAKASHI: "Developmental mechanism of low myopia and therapeutic possibilities. A review", NIPPON GANKA GAKKAI ZASSHI (1998), 102(12), 796-812, XP000916765
MASUDA, HIROSHI ET AL: "M3 -type muscarinic receptors predominantly mediate neurogenic quick contraction of bovine ciliary muscle", GEN. PHARMACOL. (1998), 30(4), 579-584, XP000916621
POYER, JOHN F. ET AL: "The effect of muscarinic agonists and selective receptor subtype antagonists on the contractile response of the isolated rhesus monkey ciliary muscle", EXP. EYE RES. (1994), 59(6), 729-36, XP000916628
PANG, IOK HOU ET AL: "Characterization of muscarinic receptor involvement in human ciliary muscle cell function", J. OCUL. PHARMACOL. (1994), 10(1), 125-36, XP000916627
GABELT, B'ANN TRUE ET AL: "Inhibition of outflow facility and accommodative and miotic responses to pilocarpine in rhesus monkeys by muscarinic receptor subtype antagonists", J. PHARMACOL. EXP. THER. (1992), 263(3), 1133-9, XP000916597
GABELT B T ET AL: "Inhibition of aceclidine-stimulated outflow facility, accommodation and miosis in rhesus monkeys by muscarinic receptor subtype antagonists.", EXPERIMENTAL EYE RESEARCH, (1994 MAY) 58 (5) 623-30., XP000916629
MASUDA, HIROSHI ET AL: "M3 -type muscarinic receptors predominantly mediate neurogenic quick contraction of bovine ciliary muscle", GEN. PHARMACOL. (1998), 30(4), 579-584, XP000916621
POYER, JOHN F. ET AL: "The effect of muscarinic agonists and selective receptor subtype antagonists on the contractile response of the isolated rhesus monkey ciliary muscle", EXP. EYE RES. (1994), 59(6), 729-36, XP000916628
PANG, IOK HOU ET AL: "Characterization of muscarinic receptor involvement in human ciliary muscle cell function", J. OCUL. PHARMACOL. (1994), 10(1), 125-36, XP000916627
GABELT, B'ANN TRUE ET AL: "Inhibition of outflow facility and accommodative and miotic responses to pilocarpine in rhesus monkeys by muscarinic receptor subtype antagonists", J. PHARMACOL. EXP. THER. (1992), 263(3), 1133-9, XP000916597
GABELT B T ET AL: "Inhibition of aceclidine-stimulated outflow facility, accommodation and miosis in rhesus monkeys by muscarinic receptor subtype antagonists.", EXPERIMENTAL EYE RESEARCH, (1994 MAY) 58 (5) 623-30., XP000916629
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