METHODS FOR SCREENING FOR ANTI-GRAYING AGENTS ON THE BASIS OF AFF-4 EXPRESSION

WIPO Patent Application WO/2010/150922

A3

An objective of the present invention is to provide an anti-graying agent. The present invention provides a method for screening an anti-graying agent whereby a substance that accelerates expression of AFF-4 in cells is selected by applying a candidate substance to cells in vitro; and, an anti-graying agent containing at least one type of herbal extract selected from the group consisting of Ganoderma lucidum (Fr.) Karst. extract, Panax schinseng Nees extract, Oryza sativa (Rice) Bran extract and Rabdosia japonicus extract selected with this method in an amount effective for accelerating expression of AFF-4.

IWABUCHI TOKURO (JP)
WEINER LORIN (US)
BRISSETTE JANICE L (US)
LI JIAN (US)

PCT/JP2010/061305

March 10, 2011

June 25, 2010

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SHISEIDO CO LTD (JP)
GEN HOSPITAL CORP (US)
IWABUCHI TOKURO (JP)
WEINER LORIN (US)
BRISSETTE JANICE L (US)
LI JIAN (US)

C12Q1/68; A61K36/074; A61K36/53

WO2008015341A2

2008-02-07

DE102006060154A1	2008-06-19
US20050191242A1	2005-09-01

JOICO LABORATORIES: "Re:nual Serum", 1 June 2009 (2009-06-01), XP007915937, [retrieved on 20101117]
BITOUN EMMANUELLE ET AL: "AF4 Is a Critical Regulator of the IGF-1 Signaling Pathway during Purkinje Cell Development", JOURNAL OF NEUROSCIENCE, vol. 29, no. 49, December 2009 (2009-12-01), pages 15366 - 15374, XP002610966, ISSN: 0270-6474

AOKI, Atsushi et al. (Toranomon 37 Mori Bldg. 5-1, Toranomon 3-chome, Minato-k, Tokyo 23, JP)

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