METHODS OF SYNTHESIS OF CHIRAL 3, 5-DISUBSTITUTED MORPHOLINE COMPOUNDS AND INTERMEDIATES USEFUL THEREIN

Title:

METHODS OF SYNTHESIS OF CHIRAL 3, 5-DISUBSTITUTED MORPHOLINE COMPOUNDS AND INTERMEDIATES USEFUL THEREIN

Document Type and Number:

WIPO Patent Application WO/2023/098882

Kind Code:

A1

Abstract:

Provided herein are diastereomer-selective synthetic methods and intermediates for making chiral 3, 5-disubstituted morpholine compounds, which are useful for the preparation of compounds useful as mitochondrial-derived activator of caspases (SMAC) mimetics for the treatment of proliferative diseases such as cancer.

Inventors:

SUN YUANMING (CN)
ZHANG QIN (CN)
YANG JIANZHANG (CN)
XU ZHONGMIN (CN)
LAI XINZHONG (CN)
DEERBERG JOERG (CN)

Application Number:

PCT/CN2022/136254

Publication Date:

June 08, 2023

Filing Date:

December 02, 2022

Export Citation:

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Assignee:

BEIGENE LTD (GB)
SUN YUANMING (CN)

International Classes:

C07C215/42; C07D265/28

Foreign References:

CN105408331A	2016-03-16
CN101801962A	2010-08-11
CN104945345A	2015-09-30

Other References:

FONTANELLA, L.: "New synthesis of 1-phenyl-2,6-dimethylpiperazine", IL FARMACO, ELSEVIER FRANCE * EDITIONS SCIENTIFIQUES ET MEDICALES, FR, vol. 37, no. fasc. 6, 31 December 1982 (1982-12-31), FR , pages 378 - 386, XP009546736, ISSN: 0014-827X

Attorney, Agent or Firm:

WU, FENG & ZHANG (CN)

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