Title:
METHODS TO SENSITIZE CANCER CELLS AND STANDARDIZED SCREENING ASSAY FOR IMMUNOTHERAPY
Document Type and Number:
WIPO Patent Application WO/2022/140082
Kind Code:
A3
Abstract:
This invention is directed to pharmaceutical compositions and methods for increasing immunogenicity in a cancer cell by contacting a cancer cell with epigenetic inhibitors to prompt the cancer cell's production of MHC-I-associated tumor antigens.
Inventors:
LU XIONGBIN (US)
ZHANG XINNA (US)
ZHANG XINNA (US)
Application Number:
PCT/US2021/062842
Publication Date:
September 22, 2022
Filing Date:
December 10, 2021
Export Citation:
Assignee:
UNIV INDIANA TRUSTEES (US)
International Classes:
A61P35/00; A61K39/395; A61P37/02; C07K16/28
Other References:
MCCAW TYLER R.; LI MEI; STARENKI DMYTRO; LIU MINGYONG; COOPER SARA J.; AREND REBECCA C.; FORERO ANDRES; BUCHSBAUM DONALD J.; RANDA: "Histone deacetylase inhibition promotes intratumoral CD8T-cell responses, sensitizing murine breast tumors to anti-PD1", CANCER IMMUNOLOGY IMMUNOTHERAPY, SPRINGER, BERLIN/HEIDELBERG, vol. 68, no. 12, 12 November 2019 (2019-11-12), Berlin/Heidelberg , pages 2081 - 2094, XP036952137, ISSN: 0340-7004, DOI: 10.1007/s00262-019-02430-9
BORUTINSKAITĖ VERONIKA, NAVAKAUSKIENĖ RŪTA: "The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 16, no. 8, 6 August 2015 (2015-08-06), pages 18252 - 18269, XP055975332, DOI: 10.3390/ijms160818252
ROBERTO PILI, NABIL ADRA, NUR DAMAYANTI, THEODORE F. LOGAN, VIVEK NARAYAN, PAUL MONK, S DROPCHO, LINA M SEGO, HAO LIU, SANDRA K. : "Immunomodulation by HDAC inhibition: Results from a phase I study with entinostat in combination with atezolizumab and bevacizumab in metastatic renal cell carcinoma patients", JOURNAL OF CLINICAL ONCOLOGY, vol. 38, no. Suppl. 15, 25 May 2020 (2020-05-25), DOI: 10.1200/JCO.2020.38.15 supp1.5064
MCCAW TYLER R, RANDALL TROY D, FORERO ANDRES, BUCHSBAUM DONALD J: "Modulation of antitumor immunity with histone deacetylase inhibitors", IMMUNOTHERAPY, FUTURE MEDICINE LTD., GB, vol. 9, no. 16, 1 December 2017 (2017-12-01), GB , pages 1359 - 1372, XP055864615, ISSN: 1750-743X, DOI: 10.2217/imt-2017-0134
BORUTINSKAITĖ VERONIKA, NAVAKAUSKIENĖ RŪTA: "The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 16, no. 8, 6 August 2015 (2015-08-06), pages 18252 - 18269, XP055975332, DOI: 10.3390/ijms160818252
ROBERTO PILI, NABIL ADRA, NUR DAMAYANTI, THEODORE F. LOGAN, VIVEK NARAYAN, PAUL MONK, S DROPCHO, LINA M SEGO, HAO LIU, SANDRA K. : "Immunomodulation by HDAC inhibition: Results from a phase I study with entinostat in combination with atezolizumab and bevacizumab in metastatic renal cell carcinoma patients", JOURNAL OF CLINICAL ONCOLOGY, vol. 38, no. Suppl. 15, 25 May 2020 (2020-05-25), DOI: 10.1200/JCO.2020.38.15 supp1.5064
MCCAW TYLER R, RANDALL TROY D, FORERO ANDRES, BUCHSBAUM DONALD J: "Modulation of antitumor immunity with histone deacetylase inhibitors", IMMUNOTHERAPY, FUTURE MEDICINE LTD., GB, vol. 9, no. 16, 1 December 2017 (2017-12-01), GB , pages 1359 - 1372, XP055864615, ISSN: 1750-743X, DOI: 10.2217/imt-2017-0134
Attorney, Agent or Firm:
BREEN, John P. et al. (US)
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