Title:
METHODS FOR TREATING DISEASE WITH ANTIBODIES TO CXCR3
Document Type and Number:
WIPO Patent Application WO2001072334
Kind Code:
A3
Abstract:
The present invention provides antibodies directed against the CXCR3 chemokine receptor protein for use in compositions and methods for the treatment, and prevention of inflammatory diseases and conditions.
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Inventors:
ARIMILLI SUBHASHINI (US)
FERLIN WALTER (FR)
DESHPANDE SHRIKANT (US)
MOCCI SIMONETTA (US)
FERLIN WALTER (FR)
DESHPANDE SHRIKANT (US)
MOCCI SIMONETTA (US)
Application Number:
PCT/US2001/009912
Publication Date:
February 21, 2002
Filing Date:
March 27, 2001
Export Citation:
Assignee:
CORIXA CORP (US)
ARIMILLI SUBHASHINI (US)
FERLIN WALTER (FR)
DESHPANDE SHRIKANT (US)
MOCCI SIMONETTA (US)
ARIMILLI SUBHASHINI (US)
FERLIN WALTER (FR)
DESHPANDE SHRIKANT (US)
MOCCI SIMONETTA (US)
International Classes:
A61P31/00; A61P37/00; C07K16/28; (IPC1-7): A61K39/395; A61P31/00; A61P37/00
Domestic Patent References:
| WO1998011218A1 | 1998-03-19 | |||
| WO2000018431A1 | 2000-04-06 |
Other References:
S. QIN ET AL.: "The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 101, no. 4, 15 February 1998 (1998-02-15), New York, NY, USA, pages 746 - 754, XP001024088
T. SÖRENSEN ET AL.: "Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients.", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 103, no. 6, March 1999 (1999-03-01), New York, NY, USA, pages 807 - 815, XP001024087
L. PIALI ET AL.: "The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and MIG.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 28, no. 3, March 1998 (1998-03-01), Weinheim, Germany, pages 961 - 972, XP001024114
S. GASPERINI ET AL.: "Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils.", THE JOURNAL OF IMMUNOLOGY, vol. 162, no. 8, 15 April 1999 (1999-04-15), Baltimore, MD, USA, pages 4928 - 4937, XP002181191
W. AGACE ET AL.: "Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 30, no. 3, March 2000 (2000-03-01), Weinheim, Germany, pages 819 - 826, XP001024111
T. SÖRENSEN ET AL.: "Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients.", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 103, no. 6, March 1999 (1999-03-01), New York, NY, USA, pages 807 - 815, XP001024087
L. PIALI ET AL.: "The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and MIG.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 28, no. 3, March 1998 (1998-03-01), Weinheim, Germany, pages 961 - 972, XP001024114
S. GASPERINI ET AL.: "Gene expression and production of the monokine induced by IFN-gamma (MIG), IFN-inducible T cell alpha chemoattractant (I-TAC), and IFN-gamma-inducible protein-10 (IP-10) chemokines by human neutrophils.", THE JOURNAL OF IMMUNOLOGY, vol. 162, no. 8, 15 April 1999 (1999-04-15), Baltimore, MD, USA, pages 4928 - 4937, XP002181191
W. AGACE ET AL.: "Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 30, no. 3, March 2000 (2000-03-01), Weinheim, Germany, pages 819 - 826, XP001024111
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