Title:
METHODS OF TREATING FUNGAL INFECTIONS WITH INHIBITORS OF NAD SYNTHETASE ENZYME
Document Type and Number:
WIPO Patent Application WO2001000197
Kind Code:
A3
Abstract:
The present invention provides methods of treating or preventing fungal infections in a host comprising administering a treatment effective or treatment effective amount of a yeast NAD synthetase inhibitor compound. The invention further provides a method of killing yeast comprising administring a yeast NAD synthetase compound that selectively binds to catalytic sites in yeast whereby the yeast is killed.
Inventors:
BROUILLETTE WAYNE J
BROUILLETTE CHRISTIE G
DELUCAS LAWRENCE J
BROUILLETTE CHRISTIE G
DELUCAS LAWRENCE J
Application Number:
PCT/US2000/018029
Publication Date:
September 07, 2001
Filing Date:
June 29, 2000
Export Citation:
Assignee:
UAB RESEARCH FOUNDATION (US)
International Classes:
A61K31/00; A61K31/216; A61K31/235; A61K31/343; A61K31/404; A61K31/4406; A61K31/4425; A61K31/443; A61K31/4439; A61K31/4709; A61K31/4725; A61K31/4745; A61K31/496; C07D213/80; A61K31/5377; A61K45/00; A61P31/10; A61P43/00; C07C229/36; C07C229/42; C07C235/60; C07C235/64; C07D209/08; C07D209/12; C07D401/06; C07D401/12; C07D498/18; C40B40/04; (IPC1-7): A61K31/00; A61K31/4439; A61K31/404; A61K31/216; A61K31/4709; A61K31/4425; A61K31/443; A61K31/235; A61K31/343; A61K31/4725; A61K31/4406; A61K31/4745; A61P31/10
Domestic Patent References:
| WO2000010996A1 | 2000-03-02 | |||
| WO1999036422A1 | 1999-07-22 |
Other References:
D.R. SHRIDHAR ET AL.: "Antimicrobial Agents: Synthesis and Antimicrobial Activity of New Aryloxyalkyl Esters of p-Hydroxybenzoic acid", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 65, no. 7, 1976, pages 1074 - 1078, XP002159389
D.R. SHRIDHAR ET AL.: "Antimicrobial Agents-Part III", J. INDIAN CHEM SOC., vol. LVI, 1979, pages 74 - 76, XP000979792
SCHMITT L J (REPRINT) ET AL: "The synthesis of tethered heterocyclic dimers as inhibitors of NAD synthetase.", ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, (23 AUG 1998) VOL. 216, PART 2, PP. 247-MEDI. PUBLISHER: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036. ISSN: 0065-7727., UNIV ALABAMA, CTR MACROMOL CRYSTALLOG, BIRMINGHAM, AL 35294;UNIV ALABAMA, DEPT CHEM, BIRMINGHAM, AL 35294, XP000981301
D.R. SHRIDHAR ET AL.: "Antimicrobial Agents-Part III", J. INDIAN CHEM SOC., vol. LVI, 1979, pages 74 - 76, XP000979792
SCHMITT L J (REPRINT) ET AL: "The synthesis of tethered heterocyclic dimers as inhibitors of NAD synthetase.", ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, (23 AUG 1998) VOL. 216, PART 2, PP. 247-MEDI. PUBLISHER: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036. ISSN: 0065-7727., UNIV ALABAMA, CTR MACROMOL CRYSTALLOG, BIRMINGHAM, AL 35294;UNIV ALABAMA, DEPT CHEM, BIRMINGHAM, AL 35294, XP000981301
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