Title:
METHODS OF TREATING LYMPHEDEMA
Document Type and Number:
WIPO Patent Application WO/2023/107608
Kind Code:
A3
Abstract:
Described are methods of treating lymphedema, methods of reducing dermal thickening, methods of improving skin turgor, structure, histology and/or function, and/or methods of improving lymphatic flow and/or vascular function in a patient in need thereof, comprising administering to said patient an effective amount of a selective LTA4H inhibitor; wherein selective LTA4H inhibitor is acebilustat, wherein the reduction in dermal thickening is measured by dermal ultrasound or skin caliper; wherein the patient has previously undergone surgery and/or radiation therapy for cancer. The method further comprising administering a second active agent, wherein the second active agent is selected from the group consisting of a COX-I inhibitor, a COX-2 inhibitor, a coumarin, an anti-histamine, montelukast and related leukotriene modifiers, an anti-fibrotic compound, a diuretics, a statin an mTOR inhibitor, and pirfenidone.
Inventors:
ROCKSON STANLEY (US)
NICOLLS MARK (US)
JIANG XINGUO (US)
TIAN WEN (US)
SPRINGMAN ERIC (US)
HEFFERNAN EILEEN (US)
NICOLLS MARK (US)
JIANG XINGUO (US)
TIAN WEN (US)
SPRINGMAN ERIC (US)
HEFFERNAN EILEEN (US)
Application Number:
PCT/US2022/052230
Publication Date:
August 03, 2023
Filing Date:
December 08, 2022
Export Citation:
Assignee:
CELLTAXIS LLC (US)
UNIV LELAND STANFORD JUNIOR (US)
UNIV LELAND STANFORD JUNIOR (US)
International Classes:
A61P17/12; A61K45/06; A61P17/02; A61K8/04; A61P17/00
Domestic Patent References:
| WO2017193099A1 | 2017-11-09 |
Foreign References:
| US20180193296A1 | 2018-07-12 | |||
| US20150111947A1 | 2015-04-23 | |||
| US20200138791A1 | 2020-05-07 |
Other References:
MARKERT CHRISTIAN, THOMA GEBHARD, SRINIVAS HONNAPPA, BOLLBUCK BIRGIT, LÜÖND RAINER M., MILTZ WOLFGANG, WÄLCHLI RUDOLF, WOLF ROMAIN: "Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 64, no. 4, 25 February 2021 (2021-02-25), US , pages 1889 - 1903, XP093041823, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c01955
BHATT L.; ROINESTAD K.; VAN T.; SPRINGMAN E.B.: "Recent advances in clinical development of leukotriene B4 pathway drugs", SEMINARS IN IMMUNOLOGY, W.B. SAUNDERS COMPANY, PA., US, vol. 33, 1 January 1900 (1900-01-01), US , pages 65 - 73, XP085238156, ISSN: 1044-5323, DOI: 10.1016/j.smim.2017.08.007
BHATT L.; ROINESTAD K.; VAN T.; SPRINGMAN E.B.: "Recent advances in clinical development of leukotriene B4 pathway drugs", SEMINARS IN IMMUNOLOGY, W.B. SAUNDERS COMPANY, PA., US, vol. 33, 1 January 1900 (1900-01-01), US , pages 65 - 73, XP085238156, ISSN: 1044-5323, DOI: 10.1016/j.smim.2017.08.007
Attorney, Agent or Firm:
ELMORE, Carolyn, S. et al. (US)
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