Title:
METHODS FOR TREATING PERIPHERAL NERVE DAMAGE
Document Type and Number:
WIPO Patent Application WO/2015/138761
Kind Code:
A3
Abstract:
VEGF-B, as well as a combination of VEGF-B and VEGF-A, mediates peripheral nerve repair. Methods to treat damage to the peripheral nervous system are described.
Inventors:
ROSENBLATT MARK (US)
GUAIQUIL VICTOR H (US)
PAN ZAN (US)
KARAGIANNI NATALIA (US)
GUAIQUIL VICTOR H (US)
PAN ZAN (US)
KARAGIANNI NATALIA (US)
Application Number:
PCT/US2015/020232
Publication Date:
November 26, 2015
Filing Date:
March 12, 2015
Export Citation:
Assignee:
UNIV CORNELL (US)
International Classes:
A61K38/18
Foreign References:
| US20110318365A1 | 2011-12-29 | |||
| US7125856B1 | 2006-10-24 |
Other References:
DHONDT ET AL.: "Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons.", FASEB J., vol. 25, no. 5., May 2011 (2011-05-01), pages 1461 - 1473, XP055238284
ZHANG ET AL.: "VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis.", PROC NATL ACAD SCI U S A., vol. 106, no. 15., 14 April 2009 (2009-04-14), pages 6152 - 6157, XP002526721
PAN ET AL.: "Vascular endothelial growth factor promotes anatomical and functional recovery of injured peripheral nerves in the avascular comea.", FASEB J., vol. 27, no. 7., July 2013 (2013-07-01), pages 2756 - 2767, XP055238285
ZHANG ET AL.: "VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis.", PROC NATL ACAD SCI U S A., vol. 106, no. 15., 14 April 2009 (2009-04-14), pages 6152 - 6157, XP002526721
PAN ET AL.: "Vascular endothelial growth factor promotes anatomical and functional recovery of injured peripheral nerves in the avascular comea.", FASEB J., vol. 27, no. 7., July 2013 (2013-07-01), pages 2756 - 2767, XP055238285
Attorney, Agent or Firm:
WARREN, William, L. et al. (999 Peachtree Street N.E.,Suite 230, Atlanta Georgia, US)
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