METHODS OF TREATING PULMONARY HYPERTENSION USING BTK INHIBITORS

Title:

METHODS OF TREATING PULMONARY HYPERTENSION USING BTK INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2024/027750

Kind Code:

A1

Abstract:

Provided herein are methods of treating pulmonary hypertension, particularly pulmonary arterial hypertension (PAH) pulmonary arterial hypertension in a subject, comprising administering to the subject in need thereof a BTK inhibitor, or a pharmaceutically acceptable salt thereof.

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Inventors:

YU MIN (CN)
KONG HUI (CN)
XIE WEIPING (CN)

Application Number:

PCT/CN2023/110700

Publication Date:

February 08, 2024

Filing Date:

August 02, 2023

Export Citation:

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Assignee:

BEIGENE SWITZERLAND GMBH (CH)
YU MIN (CN)

International Classes:

A61K31/519; A61P9/12; A61P11/00

Domestic Patent References:

WO2008077022A2	2008-06-26
WO2022031330A1	2022-02-10

Foreign References:

CN110403946A

2019-11-05

Other References:

YU MIN, WU XUECHENG, PENG LIYAO, YANG MINGXIA, ZHOU HONG, XU JIAN, WANG JINGJING, WANG HONG, XIE WEIPING, KONG HUI: "Inhibition of Bruton’s Tyrosine Kinase Alleviates Monocrotaline-Induced Pulmonary Arterial Hypertension by Modulating Macrophage Polarization", OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, HINDAWI PUBLISHING CORPORATION, US, vol. 2022, 29 August 2022 (2022-08-29), US , pages 1 - 18, XP093135585, ISSN: 1942-0900, DOI: 10.1155/2022/6526036

Attorney, Agent or Firm:

WU, FENG & ZHANG (CN)

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