Title:
METHODS OF TREATING, REDUCING, OR PREVENTING AUTOIMMUNE CONDITIONS
Document Type and Number:
WIPO Patent Application WO2005072290
Kind Code:
A3
Abstract:
The present invention relates to methods and kits for treating, reducing, or preventing autoimmune conditions such as rheumatoid arthritis by administering to a mammal in need thereof an agent that modulates the expression level or biological activity of Toll-like receptor-9 (TLR-9). Also disclosed are screening methods that make use of TLR-9 for the identification of novel therapeutics for autoimmune conditions.
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Inventors:
MATHIS DIANE J (US)
BENOIST CHRISTOPHE O (US)
WU HSIN-JUNG (US)
BENOIST CHRISTOPHE O (US)
WU HSIN-JUNG (US)
Application Number:
PCT/US2005/002097
Publication Date:
October 12, 2006
Filing Date:
January 24, 2005
Export Citation:
Assignee:
JOSLIN DIABETES CENTER INC (US)
MATHIS DIANE J (US)
BENOIST CHRISTOPHE O (US)
WU HSIN-JUNG (US)
MATHIS DIANE J (US)
BENOIST CHRISTOPHE O (US)
WU HSIN-JUNG (US)
International Classes:
C07H21/04; A01N43/04; C12N5/00; C12N15/117; C12P19/34; C12Q1/68
Domestic Patent References:
| WO2000009159A1 | 2000-02-24 |
Other References:
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SHIROTA ET AL.: "B Cells Capturing Antigen Conjugated with CpG Oligodeoxynucleotides Induce Th1 Cells by Elaborating IL-12", THE JOURNAL OF IMMUNOLOGY, vol. 169, 2002, pages 787 - 794, XP055202686, DOI: doi:10.4049/jimmunol.169.2.787
CHIANG ET AL.: "Ribavirin or CpG DNA sequence-modulated dendritic cells decrease the IgE level and airway inflammation", AM. J. RESPIR. CRIT. CARE MED., vol. 168, 2003, pages 575 - 580
GRAMZINSKI ET AL.: "Interleukin-12- and Gamma Interferon-Dependent Protection against Malaria Conferred by CpG Oligodeoxynucleotide in Mice", INFECTION AND IMMUNITY, vol. 69, 2001, pages 1643 - 1649, XP000999552, DOI: doi:10.1128/IAI.69.3.1643-1649.2001
SHIROTA ET AL.: "B Cells Capturing Antigen Conjugated with CpG Oligodeoxynucleotides Induce Th1 Cells by Elaborating IL-12", THE JOURNAL OF IMMUNOLOGY, vol. 169, 2002, pages 787 - 794, XP055202686, DOI: doi:10.4049/jimmunol.169.2.787
CHIANG ET AL.: "Ribavirin or CpG DNA sequence-modulated dendritic cells decrease the IgE level and airway inflammation", AM. J. RESPIR. CRIT. CARE MED., vol. 168, 2003, pages 575 - 580
GRAMZINSKI ET AL.: "Interleukin-12- and Gamma Interferon-Dependent Protection against Malaria Conferred by CpG Oligodeoxynucleotide in Mice", INFECTION AND IMMUNITY, vol. 69, 2001, pages 1643 - 1649, XP000999552, DOI: doi:10.1128/IAI.69.3.1643-1649.2001
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