Title:
METHODS OF USE AND KIT FOR MEASUREMENT OF LIPOPOLYSACCHARIDE WITH A TIME RESOLVED FLUORESCENCE BASED ASSAY
Document Type and Number:
WIPO Patent Application WO/2012/037361
Kind Code:
A3
Abstract:
The present invention relates to the methods of use for measurement of lipopolysaccharide (LPS) and methods of use for diagnosis of sepsis and LPS-related conditions. Specifically the present invention relates to a time resolved fluorescence (TRF) based assay for the measurement of LPS and methods of use for the measurement of LPS to diagnose sepsis, Gram-negative bacterial infections, and LPS-related conditions.
Inventors:
WILSON CONSTANCE NEELY (US)
Application Number:
PCT/US2011/051779
Publication Date:
May 18, 2012
Filing Date:
September 15, 2011
Export Citation:
Assignee:
ENDACEA INC (US)
WILSON CONSTANCE NEELY (US)
WILSON CONSTANCE NEELY (US)
International Classes:
G01N33/68; G01N33/52; G01N33/533; G01N33/92
Foreign References:
| US5773306A | 1998-06-30 |
Other References:
WARNER, G. ET AL.: "Time-Resolved Fluorescence Based GTP Binding Assay for G-Protein Coupled Receptors", PERKINELMER LIFE SCIENCES, 2002, XP055103209
WILSON, C.N. ET AL.: "Lipopolysaccharide Binds to and Activates A( 1) Adenosine Receptors on Human Pulmonary Artery Endothelial Cells", J ENDO TOXIN RES, vol. 8, no. 4, 2002, pages 263 - 271, XP009098939
COHEN, J.: "The Immunopathogenesis of Sepsis", NATURE, vol. 420, December 2002 (2002-12-01), pages 885 - 891, XP002449666
NGAMSRI, K-C. ET AL., ADENOSINE RECEPTOR AL REGULATES POLYMORPHONUCLEAR C ELL TRAFFICKING AND MICROVASCULAR PERMEABILITY IN LIPOPOLYSACCHARIDE-INDUCED LUNG INJURY, vol. 185, 20 August 2010 (2010-08-20), pages 4374 - 4384, XP055105610
See also references of EP 2616817A4
WILSON, C.N. ET AL.: "Lipopolysaccharide Binds to and Activates A( 1) Adenosine Receptors on Human Pulmonary Artery Endothelial Cells", J ENDO TOXIN RES, vol. 8, no. 4, 2002, pages 263 - 271, XP009098939
COHEN, J.: "The Immunopathogenesis of Sepsis", NATURE, vol. 420, December 2002 (2002-12-01), pages 885 - 891, XP002449666
NGAMSRI, K-C. ET AL., ADENOSINE RECEPTOR AL REGULATES POLYMORPHONUCLEAR C ELL TRAFFICKING AND MICROVASCULAR PERMEABILITY IN LIPOPOLYSACCHARIDE-INDUCED LUNG INJURY, vol. 185, 20 August 2010 (2010-08-20), pages 4374 - 4384, XP055105610
See also references of EP 2616817A4
Attorney, Agent or Firm:
PASSE, James, G. (LLC1717 Brassfield Roa, Raleigh NC, US)
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