Title:
METHODS OF USING A MYCOBACTERIUM TUBERCULOSIS CODING SEQUENCE TO FACILITATE STABLE AND HIGH YIELD EXPRESSION OF HETEROLOGOUS PROTEINS
Document Type and Number:
WIPO Patent Application WO2001025401
Kind Code:
A9
Abstract:
The present invention relates generally to nucleic acid and amino acid sequences of a fusion polypeptide comprising a Mycobacterium tuberculosis polypeptide, and a heterologous polypeptide of interest, expression vectors and host cells comprising such nucleic acids, and methods for producing such fusion polypeptides. In particular, the invention relates to materials and methods of using such M. tuberculosis sequence as a fusion partner to facilitate the stable and high yield expression of recombinant heterologous polypeptides of both eukaryotic and prokaryotic origin.
Inventors:
SKEIKY YASIR (US)
GUDERIAN JEFFREY (US)
GUDERIAN JEFFREY (US)
Application Number:
PCT/US2000/027652
Publication Date:
September 26, 2002
Filing Date:
October 06, 2000
Export Citation:
Assignee:
CORIXA CORP (US)
SKEIKY YASIR (US)
GUDERIAN JEFFREY (US)
SKEIKY YASIR (US)
GUDERIAN JEFFREY (US)
International Classes:
C12N15/09; C07K14/35; C07K14/47; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12P21/04; (IPC1-7): C12N/
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