Title:
METHYLOPHIOPOGONONE A DERIVATIVE, AND PREPARATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/027521
Kind Code:
A1
Abstract:
Provided are a methylophiopogonone A derivative, and the preparation and the use thereof. The present invention specifically relates to three derivatives of methylophiopogonone A, which derivatives have the chemical structures of formula I, formula II and formula III; and a method for preparing the derivatives, and the use of the derivatives in the preparation of a drug for preventing and/or treating cardiovascular diseases, etc.
Inventors:
ZHANG JINLAN (CN)
SUN HUA (CN)
WANG DONGMEI (CN)
LIU YANXIN (CN)
CHEN ZIHAN (CN)
CHEN ZHIWEI (CN)
SHENG NING (CN)
WANG ZHE (CN)
ZHENG BOWEN (CN)
LIN MODI (CN)
SUN HUA (CN)
WANG DONGMEI (CN)
LIU YANXIN (CN)
CHEN ZIHAN (CN)
CHEN ZHIWEI (CN)
SHENG NING (CN)
WANG ZHE (CN)
ZHENG BOWEN (CN)
LIN MODI (CN)
Application Number:
PCT/CN2023/108779
Publication Date:
February 08, 2024
Filing Date:
July 23, 2023
Export Citation:
Assignee:
INST OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCICENCES (CN)
International Classes:
C07D407/06; A61K31/352; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12
Foreign References:
| CN102127042A | 2011-07-20 |
Other References:
YADAV SANTOSH KUMAR: "New Convenient Synthesis of 8-C-Methylated Homoisoflavones and Analysis of Their Structure by NMR and Tandem Mass Spectrometry", INTERNATIONAL JOURNAL OF ORGANIC CHEMISTRY, SCIENTIFIC RESEARCH PUBLISHING, INC., US, vol. 11, no. 01, 1 January 2021 (2021-01-01), US , pages 46 - 54, XP093134704, ISSN: 2161-4687, DOI: 10.4236/ijoc.2021.111005
WANG YAN-HUI, QIU CONG, WANG DA-WEI, HU ZHENG-FANG, YU BO-YANG, ZHU DAN-NI: "Identification of multiple constituents in the traditional Chinese medicine formula Sheng-Mai San and rat plasma after oral administration by HPLC–DAD–MS/MS", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, ELSEVIER B.V., AMSTERDAM, NL, vol. 54, no. 5, 1 April 2011 (2011-04-01), AMSTERDAM, NL , pages 1110 - 1127, XP093134715, ISSN: 0731-7085, DOI: 10.1016/j.jpba.2010.11.034
TEPONNO RÉMY B., PONOU BEAUDELAIRE K., FIORINI DENNIS, BARBONI LUCIANO, TAPONDJOU LÉON A.: "Chemical Constituents from the Roots of Furcraea bedinghausii Koch", INTERNATIONAL LETTERS OF CHEMISTRY, PHYSICS AND ASTRONOMY, vol. 16, 2013, pages 9 - 19, XP093134719, ISSN: 2299-3843, DOI: 10.56431/p-i1m5h3
DENG XU, XU JINJU, TONG CHAOYING, SHI FANGYING, SHI SHUYUN: "Homoisoflavonoids profiling of Ophiopogon japonicus by off‐line coupling high‐speed countercurrent chromatography with high‐performance liquid chromatography–diode array detector‒quadrupole time‐of‐flight tandem mass spectrometry", JOURNAL OF SEPARATION SCIENCE, WILEY, DE, vol. 43, no. 8, 1 April 2020 (2020-04-01), DE , pages 1406 - 1414, XP093134723, ISSN: 1615-9306, DOI: 10.1002/jssc.201901222
HE FEI, XU BANG-LONG, CHEN CAI, JIA HONG-JING, WU JI-XIONG, WANG XIAO-CHEN, SHENG JIAN-LONG, HUANG LI, CHENG JING: "Methylophiopogonanone A suppresses ischemia/reperfusion-induced myocardial apoptosis in mice via activating PI3K/Akt/eNOS signaling pathway", ACTA PHARMACOLOGICA SINICA, NATURE PUBLISHING GROUP, GB, vol. 37, no. 6, 1 June 2016 (2016-06-01), GB , pages 763 - 771, XP093134724, ISSN: 1671-4083, DOI: 10.1038/aps.2016.14
WANG YAN-HUI, QIU CONG, WANG DA-WEI, HU ZHENG-FANG, YU BO-YANG, ZHU DAN-NI: "Identification of multiple constituents in the traditional Chinese medicine formula Sheng-Mai San and rat plasma after oral administration by HPLC–DAD–MS/MS", JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, ELSEVIER B.V., AMSTERDAM, NL, vol. 54, no. 5, 1 April 2011 (2011-04-01), AMSTERDAM, NL , pages 1110 - 1127, XP093134715, ISSN: 0731-7085, DOI: 10.1016/j.jpba.2010.11.034
TEPONNO RÉMY B., PONOU BEAUDELAIRE K., FIORINI DENNIS, BARBONI LUCIANO, TAPONDJOU LÉON A.: "Chemical Constituents from the Roots of Furcraea bedinghausii Koch", INTERNATIONAL LETTERS OF CHEMISTRY, PHYSICS AND ASTRONOMY, vol. 16, 2013, pages 9 - 19, XP093134719, ISSN: 2299-3843, DOI: 10.56431/p-i1m5h3
DENG XU, XU JINJU, TONG CHAOYING, SHI FANGYING, SHI SHUYUN: "Homoisoflavonoids profiling of Ophiopogon japonicus by off‐line coupling high‐speed countercurrent chromatography with high‐performance liquid chromatography–diode array detector‒quadrupole time‐of‐flight tandem mass spectrometry", JOURNAL OF SEPARATION SCIENCE, WILEY, DE, vol. 43, no. 8, 1 April 2020 (2020-04-01), DE , pages 1406 - 1414, XP093134723, ISSN: 1615-9306, DOI: 10.1002/jssc.201901222
HE FEI, XU BANG-LONG, CHEN CAI, JIA HONG-JING, WU JI-XIONG, WANG XIAO-CHEN, SHENG JIAN-LONG, HUANG LI, CHENG JING: "Methylophiopogonanone A suppresses ischemia/reperfusion-induced myocardial apoptosis in mice via activating PI3K/Akt/eNOS signaling pathway", ACTA PHARMACOLOGICA SINICA, NATURE PUBLISHING GROUP, GB, vol. 37, no. 6, 1 June 2016 (2016-06-01), GB , pages 763 - 771, XP093134724, ISSN: 1671-4083, DOI: 10.1038/aps.2016.14
Download PDF: